Method of tobacco dependence treatment
SUBSTANCE: group of inventions refers to medicine, namely to narcology, and can be used in treatment of tobacco dependence. To treat tobacco dependence in a smoker and rendering assistance to him in the refusal of tobacco-containing products without the appearance of withdrawal symptoms, they conduct conversations to educate the smoker about the shortcomings of smoking and its harmful effects, while conversation is conducted in presence of assistant. Perform a program of intensive detoxification at home (IDD), which lasts no more than 24 hours to remove toxins from the body of the smoker. And the IDD program includes compliance with prescribed dietary measures, including the intake of antioxidant natural foods. At the same time, part of the IDD program includes the step of introducing a drinking solution based on aloe vera, which contains natural aloe vera suspended in a drinking solution, while the assistant supervises the IDD program. Maintain an established diet that includes a list of antioxidant natural foods to eat with each meal, and oral hygiene, including the use of an aloe vera toothpaste, for a predetermined period after the completion of the IDD program. In this case, the administration of a drinking solution based on aloe vera is continued for a predetermined period of time and exclude the use of medicines to control the symptoms of withdrawal syndrome.
EFFECT: group of inventions allows to get rid of tobacco dependence and tobacco-containing products without withdrawal syndrome symptoms due to intensive detoxification, diet and hygiene.
SUBSTANCE: method involves the fasting oral administration of placenta hydrolysate 2ml in water 200 ml at a temperature of 37°C in the morning. After that, the patient is laid down on his/her back and exposed to infrared laser light generated by the laser scanning physiotherapeutic simulator SLSF-03.2 IK. An initial end face output power is 2 mW at a power flow density of 50 mW/cm2 on a projection of an ulcer defect on frame No. 57 or No. 59 with laser light modulation at a frequency of 12-15 a second for 3 minutes per one field. That is followed by exposing a projection of a bend of the elbow on frame No. 30 or No. 40 for 10 minutes per a field. Further, the patient stays in the same position to perform transcranial electric stimulation generated by the Doctor TES-03 apparatus. A gel forehead electrode (+) is applied in the middle of the forehead skin until adhered to the skin uniformly. Two gel postaural electrodes are applied on bony mastoid processes (-) until adhered to the skin uniformly. The electrodes are fixed with a headband. The exposure has a current intensity of 1.5 mA in the form of a bipolar pulsing frequency of 77.5 Hz for 20 minutes. The therapeutic course makes 10 daily procedures.
EFFECT: method provides reducing pain and dyspeptic syndromes, asthenovegetative syndrome, accelerating ulcerous process healing in the mucous membrane, achieving a stable remission, normalising the functional state of the adjacent organs, namely the liver, pancreas, reducing a desire to smoke up to a complete smoking cessation completely for the whole period of treatment.
4 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a percutaneously absorbable layer having a base and an adhesive layer which is placed on the base and which comprises an adhesive agent and a therapeutic ingredient. The adhesive agent contains a mixture of resins containing 100 portions by weight of an acrylic copolymer (A) and 0.1 to 30 portions by weight of an acrylic copolymer (B) or 0.05 to 2 portions by weight of a low-molecular polyamine compound having at least two amino groups in one molecule and non-polymerising with a polymer or an oligomer formed. The adhesive layer additionally contains an organic acid. The acrylic copolymer (A) represents an acrylic copolymer, which contains acrylic ester of (meth)acrylic acid as a main monomer ingredient and contains 3 to 45 wt % of diacetone acrylamide as a target monomer ingredient, but free from a free carboxylic group. The acrylic copolymer (B) represents an acrylic copolymer, which contains acrylic ester of (meth)acrylic acid as a main monomer ingredient and contains a primary amino group and/or carboxyhydrazidase group on side chains, but free from a free carboxylic group.
EFFECT: reducing the aging period of the adhesive layer considerably.
7 cl, 8 tbl, 39 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to a composition for treating nicotine addiction by means of an electronic device intended to simulate tobacco smoking. A pharmaceutical composition for treating nicotine addiction by means of the electronic device comprising a cartridge simulating tobacco smoking with the use of vapour or fog generating compound containing water, glycerol, propylene glycol, contains citric acid additionally, as well as varenicline, or anabasin hydrochloride, or cytisin taken in certain relations. A method for preparing the pharmaceutical composition by mixing water, glycerol, propylene glycol and citric acid, as well as varenicline, or anabasin hydrochloride, or cytisin. The cartridge of the electronic device for simulating tobacco smoking. A method of treating nicotine addiction by means of simulating tobacco smoking by means of the electronic device.
EFFECT: pharmaceutical composition described above enables treating nicotine addiction effectively.
4 cl, 2 dwg, 5 tbl, 15 ex
SUBSTANCE: invention refers to medicine, namely to psychiatrics, addictology and concerns treating addiction. That is ensured by an integrated treatment, involving administering homeopathic therapeutic agents, a reflex therapy covering biologically active points (BAPs) and a transcranial electric stimulation of the endorphine system. The homeopathic therapeutic agent is selected taking into account a body type, a temperament type, patient's personality.
EFFECT: method provides the effective treatment of a wide range of addictions by administering therapeutic agents selected taking into account the patient's characteristics combined with the reflex therapy and the transcranial electric stimulation of the endorphine system.
7 cl, 5 ex
SUBSTANCE: invention refers to medicine, namely to addictology, and concerns treating the patients with tobacco addiction. That is ensured by the 12-day therapeutic course. For this purpose, Teraligen is administered in a daily dose of 15-20 mg. What is also involved is mesodiencephalic modulation with low frequency currents 60-90 Hz, duration 3-5 ms, amplitude 1-5 mV for 35-45 minutes when the electrodes are placed in an occipitofrontal region. That is also combined with inhalations of atrovent in a dose of 0.7-1.5 ml in normal saline 3 ml and lasolvan in a dose of 0.8-1.2 ml in normal saline 3 ml on the first day. The same doses of the above preparations are inhaled in a combination in normal saline 2 ml on the following days. The treatment is added with a vacuum massage in a pulse mode of amplitude 100-500 mbar and frequency 0.8-2.5 Hz.
EFFECT: method prevents or reduces the intensity of psycho-vegetative disorders and recovers the ventilation function in the patients in the smoking cessation state that ultimately increases the number of patients stopping smoking completely.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine. There are described specific types of nicotin-containing chewing gums providing high transbuccal absorption rate, high plasma concentrations for the first 10 minutes after use in an individual chosen to give up smoking.
EFFECT: higher efficiency.
10 cl, 3 tbl, 35 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: there are presented methods of treating or preventing an addiction or recurrent addictive behaviour, including: alcohol, nicotine, marijuana, marijuana derivative, opioid receptor antagonist, benzodiazepine, barbiturate and psychostimulant by administering the peroxisome proliferator-activated receptor gamma (PPARγ) agonist thiazolidinedione, alone or in a combination with another therapeutic agent - an opioid receptor agonist, a mixed partial opioid receptor agonist/antagonist, an anti-depressant, an antiepileptic agent, an antiemetic agent, a corticotrophin releasing factor 1 (CRF-1) receptor antagonist, a selective serotonin 5-HT3 receptor antagonist, a 5-HT2A/2C antagonist or a cannabinoid 1 (CB1) receptor antagonist (versions), related pharmaceutical compositions with the above combinations (versions), a standard dosage form (versions) and kits (versions).
EFFECT: it is shown that the PPARγ agonist pioglitazone had no effect on amphetamine sensitisation, however it reduced opiate consumption and opiate addiction, also reduced nicotine self-administration in rats, and reduced alcohol consumption if synergistically combined with topiramate Pioglitazone reduced ethanol self-administration in rats.
33 cl, 23 dwg, 27 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to medicine, namely consisting of many portions of an oral dosage form containing at least two portions; each of the above two portions comprises at least one pharmaceutically active agent or an agent specified from a teeth whitening agent, an oral health agent, an oral anti-caries agent, a saliva-enhancing agent and/or herbal extracts wherein at least one of the above two portions comprises a pharmaceutically active agent selected from a group consisting of nicotine compounds, wherein the above at least two portions comprise a different flavour to notice the user that the above on the pharmaceutically active agent or the agents selected from the teeth whitening agent, the breath agent, the oral health agent, the anti-caries agent, the saliva-enhancing agent, and herbal extract, got to release from the above portion; and the above dosage form is other than a chewing gum.
EFFECT: invention provides creating the organoleptic feeling when digesting nicotine.
14 cl, 19 ex, 31 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: what is presented is a composition for nicotinic immunonanotherapy containing synthetic nanocarriers having a polymeric surface conjugated with a variety of nicotine residues with the variety of the nicotinic residues on the nanocarrier form an immunogenic surface providing a low affinity, a high-avidity binding of the nicotinic residues to the surfaces of an antigen presenting cell (APC) compared with an antibody binding, and a pharmaceutically acceptable excipient. The invention provides the nanocarriers capable to stimulate an immune response in T-cells and/or B cells and to produce the antinicotin antibodies with the humoral and cellular response to be achieved in the absence of an exogenous adjuvant.
EFFECT: invention provides the absence of the non-specific response on an inflammation caused by an adjuvant.
17 cl, 37 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to bupropion hydrobromide and formulations thereof, and applications thereof. The pharmaceutical composition contains an effective amount of bupropion hydrobromide, and at least one pharmaceutically acceptable adjuvant. The composition is applicable as a drug for preventing and/or decreasing a rate of convulsions and/or attacks associated with the administration of bupropion, in treating major depressive disorder, bipolar affective disorder, other affective disorders, anxiety disorder, general neurotic syndrome, panic disorder, posttraumatic stress disorder, nicotine addiction, obesity, attention deficit/hyperactivity disorder, restless legs syndrome (Ekbom syndrome), sexual dysfunctions and seasonal mood disorders.
EFFECT: invention provides reducing serious side-effects associated with the administration of bupropion.
9 cl, 54 dwg, 42 tbl, 8 ex
SUBSTANCE: speech stimulation in a child is three-staged. At the first stage, pronouncing involuntary consonants is induced and reinforced in a game situation with the use of an association of an object movement and a gesture to allow the child reproducing them voluntarily. The sound reproduced during the game is accompanied with a gesture associated with the object movement until a strong relationship of the specific sound and the object is formed; the gesture and object motion are supposed to mean the same sound. Thereafter, the child is trained to pronounce the consonants missing in his/her speech by blowing out an air flow, which is blocked by obstructions formed by articulation organs; the consonants are reinforced in the game situation with using the object movement and gesture accompanying the sound pronunciation; the gesture and object motion are supposed to mean the same sound. The second stage involves practicing how to complete the word pronunciation with the use of an effect of an unstressed syllable fixation to a stressed one, and/or unstable music fixation to a stable one, and/or how to complete a rhythmically specified word structure. That is followed by practicing words consisting of two or three open syllables and one closed syllable. The third stage provides practicing pronouncing an expression with the use of a combination of its rhythmic-melodic structure, gestures, pictures and/or objects symbolising the whole word.
EFFECT: method enables accelerating sound induction, voluntary sound pronunciation, increasing the efficiency of training the word pronunciation by the child by applying logopedic approaches.
SUBSTANCE: invention refers to restorative medicine and can be used for the drug-free correction, prevention and rehabilitation of the functional state and the enhancement of adaptability in patients of various age groups suffering various psychoneurological symptoms. There are performed three successive stages: setting (SS), adaptation (AS) and tactile contact (TCS). The SS involves introducing the patient into dolphins' organisation and behaviour characteristics, instructing to perform commands required for communication with a dolphin, and tactile contact with a dolphin. The adaptation stage involves meeting the living dolphin and contacting it directly on a swimming pool platform out of water. The TCS involves doing the exercises to develop patient's communicative abilities, fine motor skills, motor coordination, motor activity control, emotional state and attention with the use of art therapy elements, musical exercises together with the dolphin, action games with the dolphin using various objects. The TCS is performed in the swimming pool filled with mineral water NaCl 1.8-2.0 ppm at temperature from 25 to 28 degrees; the whole correction course involves from 10 to 14 sessions, from 30 to 40 min each. The SS length is at least 3 sessions of 30 min each; the AS is from 1 to 3 sessions of 30-35 min each; the TCS includes from 7 to 9 sessions of 35-40 min each.
EFFECT: method provides the higher stress stability and adaptation potential of the patient of any degree of functional preparation, the integral enhancement of communicative ability and orientation to active targeted activity, the optimised length of the rehabilitation course depending on the patient's psychoemotional state and abilities.
4 cl, 6 dwg, 3 ex, 4 tbl
SUBSTANCE: anaesthetising patients with chronic pain syndrome undergoing a cyclophotocoagulation surgery involves the intravenous administration of the hormonal preparation dexamethasone in a dose of no more than 8 mg followed by the anxiolytic droperidol in a dose of no more than 2.5 mg 5 minutes prior to the operation before the peribulbar anaesthesia. A peripheral block in the form of the peribulbar anaesthesia involving administration of no more than 6 ml of a local anaesthetic follows. At the moment the surgical procedure starts, benzodiazepin, e.g. diazepam, is administered in a dose of no more than 5 mg.
EFFECT: achieving adequate anaesthesia in the given category of patients by blocking all the links of a pathological pain chain.
SUBSTANCE: invention relates to medicine and can be used in case if it is necessary to reduce excessive weight in patients. For this purpose, passive fixation of upper and lower jaws to each other, completely excluding possibility of chewing food, is performed by means of intraoral devices. Passive fixation of jaws is provided due to levelling and connection of intra-oral devices with respect to each other without taking into account direction of growth and shape of teeth. For the period from 1 to 3 weeks feeding is performed only with liquid food. After 1-3 weeks fixation of jaws is removed and feeding with individually selected diet in combination with individually selected physical exercise is realised. Procedure of fixation is repeated until result is obtained. Method ensures effective and comfortable reduction f body weight in patients with obesity due to reduction of nutrition caloric intake by application of jaws fixation, completely preventing possibility of chewing solid food, without producing any effect on teeth, eliminating necessity of "correct" orthodontic fixation of applied devices, as well as due to application of additional complex of procedures.
EFFECT: increase of method efficiency.
7 cl, 24 dwg
SUBSTANCE: device for correction of sleep characteristics contains sensor for registration of electrodermal activity EDA, connected with unit of analysis and extraction of signals of skin-galvanic responses SGR, generator of stimulating electric pulses, on-skin electrodes and control unit. Device is made in form of monoblock with possibility of fastening on user's palm. Monoblocks case has front and back side, and fastening elements. Three electrodes, placed with possibility of galvanic connection with skin of user's hand palm, are located on back part. Measuring electrode is connected to input of sensor for EDA registration, with stimulating electrode being connected to output of generator of electric pulses, with the third one being common neutral electrode of galvanic circuits of said sensor and generator. Units of analysis and extraction of SGR signals and control unit are made on base of microprocessor with possibility of periodical control of current condition of galvanic contact of electrodes with skin, cyclic measuring of SGR intensity and supply of stimulating electric pulses in pauses between SGR measuring, and provide three modes of functionality: sleeping mode - in absence of galvanic contact of electrodes with skin; mode of EDA registration - in presence of galvanic contact of electrodes with skin, including extraction of SGR pulses and counting their quantity N for given time interval and comparison with threshold value; mode of stimulation - if quantity N of SGR pulses exceeds threshold value, including periodical supply of electric pulses to stimulating electrodes during specified time interval.
EFFECT: invention application makes it possible to extend arsenal of technical means for correction of patient's physical condition during sleep and further wakefulness, increase index of slow-wave sleep stage, power of delta-waves and therefore deepen sleep sensation, phases of fast eye motions, and increase sleep quality in general.
9 cl, 10 dwg
SUBSTANCE: invention refers to medicine, particularly to psychology, and can be used for individual and mass screening in sociology and management. A person being tested is presented with a number of pictures to be selected. The pictures are composed so that each picture contains an image that combines two archetypes with adequate shape and background. The person being tested is suggested to select among the presented number of pictures the most relevant of his/her personality evaluation and to sample. The person being tested is suggested to assign a score to the selected picture. The numerical treatment of the results involves summing up the assigned scores of the same archetypes. The number of pictures can make 20 with each picture containing two combined images with the total number of archetypes equal to 10. The total score is distributed among 1 to 8, whereas the maximum diagnostic number is equal to 10, which is when exceeded enables stating an archetypic identity.
EFFECT: method enables assessing the archetypic identity, the presence of neurotic pattern and intrapersonal conflicts by analysing the archetype-based psychological personality profile.
5 cl, 2 dwg, 1 tbl
SUBSTANCE: method includes carrying out general hydrodynamic massage (GHDM) and hydrodynamic massage of the area to be influenced, gut lavage, and psychotherapy. Procedures of massage are carried out by means of a nozzle, which ensures the supply of water by a water funnel principle. GHDM procedures are carried out 3 days running, with the following one-day break. During massage the entire body surface is processed, including the head. Procedures of hydrodynamic massage of the area to be influenced are carried out along massage lines and before GHDM and gut lavage procedure. Procedures of gut lavage are carried out on the days, when GHMD is not carried out. Psychotherapy is carried out in the form of music therapy, realised at the background of GHDM, hydrodynamic massage of the area to be influenced and gut lavage. Carrying out GHDM is accompanied by the music therapy of a relaxing nature, and carrying out gut lavage and hydrodynamic massage of the area to be influenced by the music therapy of a tonic nature. The method is carried out for 5-7 days before the influence. The procedures are carried out daily. The course starts from carrying out hydrodynamic massage.
EFFECT: achievement of fast healing after carrying out dermatocosmetological procedures due to an improvement of tropism of the area subjected to the impact, acceleration of a reparative process, increase of the immune system activity, improvement of the organism's functional condition, reduced risk of development of side effects and complications of the following cosmetological treatment.
7 cl, 2 tbl
SUBSTANCE: method includes taking radon bath with radon concentration 1.5 kBq (40 nCu/l), temperature 36-37°C, 10-15 minute duration. Source includes 10 procedures. Patient is given a session of listening to relaxing music 40 minutes after taking radon bath. After that, 5 symmetrical scalp zones are exposed to laser radiation for 30-40 seconds. Impact is realised by wavelength 0.82 mcm, power 12 mW, in pulse mode, with frequency 50 Hz. Sessions are carried out daily. Course includes 10 procedures.
EFFECT: method reduces treatment terms due to normalisation of brain blood supply, improvement of state of suprasegmental formations of vegetative nervous system.
5 ex, 6 tbl
SUBSTANCE: invention relates to medicine, namely to endocrinology, cardiology, psychotherapy and can be used for the treatment of patients with metabolic syndrome. Diet therapy of a reduced caloric content with the restriction of carbohydrate-containing products and fats, with the determination of a glycemic index with the inclusion into the diet of carbohydrate-containing products with the glycemic index lower than 40. When the initial body weight decreases by 5% and stabilisation of the weight takes place for 3 months, the caloric content of food is increased to a calculated value, determined for the patient by formula for the calculation of the daily caloric content. Carbohydrate-containing products with the glycemic index of 40-69 are introduced into the diet until the weight decreases to a specified level. Screening survey is performed, disorders of an affective spectrum are diagnosed and in case of their presence testing the patients of the identified group by Zung scale is carried out. A session from Assagioli psychosynthesis - "Temple of Silence", Coue self-hypnosis are carried out, with the multiple repetition of the same formula "I feel silence and quiet around me, I am enveloped by sunlight, I easily follow the doctors' recommendations, I am in a good mood and have good working capacity" before falling asleep and on waking up.
EFFECT: method makes it possible to achieve the stable and long-term reduction of insulin-resistance, abdominal obesity, correction of metabolic disorders, increase compliancy, improvement of the mood, increase of a self-assessment level, as well as increase the self-confidence, change the "internal picture of the disease" towards the positive side, improve psychic and somatic condition due to the complex application of diagnostics and psychotherapeutic methods.
3 tbl, 1 ex
SUBSTANCE: method includes carrying out complex treatment at the background of diet therapy. Intake of antihelmintic of vegetable origin and immunomodulator is carried out daily with washing down each of them with 200 ml of radon water. Intestinal lavage is performed every second day. On days of performing intestinal lavage, patient takes bath with radon water in the morning before lavage, with performing underwater hydrodynamic massage (UHM) on other days. On days, when intestinal lavage is not performed, sessions of sound therapy are carried out after UHM.
EFFECT: method provides correction of biological age of organism as prevention of premature ageing.
3 cl, 4 tbl, 2 ex
SUBSTANCE: invention refers to veterinary science and consists in a method for cell immunity activation in vitro with homeopathic medicines. A leukocyte suspension 0.5 ml is added with a homeopathic medicine 0.5 ml diluted in normal saline; the prepared solution is placed into a thermostat for 1 hour at T=37±0.5°C; the solution is added with a microbial reference strain Staphylococcus albus No.182 suspension 0.5 ml containing 109 CFU in normal saline 1 ml; the new solution is placed into the thermostat for 30 minutes at T=37±0.5°C; after incubation, blood smears are fixed in alcohol-formalin for 10 minutes and stained according to Romanowsky-Giemsa for 30 minutes.
EFFECT: cell immunity activation.
3 tbl, 3 ex