Method of producing complex acid salts of divalent metals of dicarboxylic acids

FIELD: chemistry.

SUBSTANCE: method of producing complex acid salts of divalent metal dicarboxylic acids of general formula: Me(AcH)2⋅nH2O, where Me is a divalent metal atom, Ac is an anion of the dicarboxylic acid, H is hydrogen, n is 0-8, is carried out by neutralisation in an aqueous medium, with an oxide of the general formula MeO, where Me is a divalent metal atom, where high, more than 95 wt %, purity of the final product is provided by the molar concentration of the dicarboxylic acid and the divalent metal oxide in the aqueous solution in a ratio of 2.005 to 2.1:1. The synthesis is carried out in such a way that a constant, equal to the original, ratio between all components of the reaction is maintained in the reaction volume. Suitable acids are succinic, fumaric, L-aspartic, L,D-aspartic acids, and as oxides - calcium oxide, magnesium oxide, zinc oxide.

EFFECT: improved method.

7 cl, 8 ex

 



 

Same patents:

FIELD: electricity.

SUBSTANCE: invention relates to the electroluminescent device. The device contains hole injecting layer, hole transport layer, electronic block layer, active luminescent layer based on luminescent substance, hole-block layer, electronic transport layer, electronic injecting layer. As the luminescent substance it contains bis[2-(N-tosylamino)-benzylidene-2-aminopyridinato] of zinc (II) of formula I: .

EFFECT: electroluminescent device based on chelate complexes of zinc of azometin derivants 2-(N-tosylaminobenzaldehyde), emitting in yellow-green spectrum.

6 dwg, 1 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry and chemical technology, namely to synthesis of modified silicagels, containing molecules of substituted phthalocyanines covalently bound with them, and their application for water photoremediation. Method of water photoremediation with application of radiation of visible range in presence of oxygen and heterogenic sensibiliser of general formula: , where R=H is either SPh; X is anion; n=4-8; M=Zn, AlL, GaL, SiLz; L=Cl, OH; M=1-4.

EFFECT: invention makes it possible to carry out efficient purification of water from bacteriological contamination.

2 cl, 3 tbl, 11 ex

FIELD: chemistry.

SUBSTANCE: invention relates to zinc complexes of 5-[2-hydroxy(tosylamino)benzylidene-amino]-2-(2-tosylaminophenyl)-1-alkylbenzimidazoles of general formula I , where R = alkyl C1-C6; X=O, ; .

EFFECT: compounds I exhibit luminescent properties and can be used as luminophores for producing organic light-emitting diodes emitting white and visible light.

18 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel metal chelates, namely to zinc and cadmium complexes of tetradentate azomethines of 2-tosylaminebenzaldehyde and dioxydiamines of formula I , where m=2-4, n=2-4, M=Zn, Cd.

EFFECT: metal-complex compounds I demonstrate photoluminiscent properties in the blue spectrum region and can be used as an electroluminescent layer in the creation of organic light-emitting diodes (OLED) of white and visible light.

4 cl, 5 ex

FIELD: chemistry.

SUBSTANCE: claimed is a silicon-zinc-containing glycerohydrogel, possessing a wound healing, regenerative and antibacterial activity, a composition of which corresponds to formula kSi(C3H7O3)4·ZnC3H6O3·xC3H8O3·yH2O, where 1≤k≤4, 7≤x≤26, 20≤y≤100, obtained by interaction of tetraglycerolate of silicon in excess of glycerol Si(C3H7O3)4·xC3H8O3, where 0,5≤x≤10, monoglycerolate of zinc in abundance of glycerol ZnC3H6O3·6C3H8O3 and water in molar ratio Si(C3H7O3)4:ZnC3H6O3:C3H8O3:H2O equal to (1÷4):1:(7÷26):(20÷100) at a temperature of 20-40°C and intensive mixing.

EFFECT: claimed silicon-zinc-containing glycerohydrogel possesses the wound healing, regenerative and antibacterial activity, is simple to obtain and convenient in application.

1 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds in a series of chelate complexes of zinc with azomethine derivatives, namely to bis[2-(N-tozylamino)benzyliden-4'-dimethylaminophenyliminato]zinc(II) of formula I Also claimed is electroluminescent device.

EFFECT: invention makes it possible to obtain compounds, demonstrating electroluminescent properties with high brightness.

2 cl, 3 dwg, 1 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: described are 15-crown-5- and dithia-18-crown-6-containig 2-methyl-9-styryl phenanthrolines of formula: where as optical sensors on cations of calcium, barium and lead. Claimed compounds are obtained by interaction of ligand of 15-crown-5 or dithia-18-crown-6-containing 2-methyl-9-styryl phenanthroline with zinc perchlorate in acetonitrile with irradiation with red light.

EFFECT: complexes possess properties of highly efficient fluorescent sensors on cations of calcium, barium and lead, which make it possible to visually determine metal cation.

2 cl, 2 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to zinc complex of asymmetric ethylenediamine-N,N-dipropyonic acid dichloride of formula Also claimed is method of its obtaining. Complex can be applied for solution of problems, associated with the necessity to introduce Zn2+ in chelate form instead of its mineral salts, as well as to serve as initial product for synthesis of other chemical compounds of series of polydentate ligands, in particular asymmetric ethylenediamine-N,N-dipropyonic acid.

EFFECT: obtaining zinc complex of asymmetric ethylenediamine-N,N-dipropyonic acid dichloride.

4 cl, 4 dwg, 3 ex

FIELD: biotechnologies.

SUBSTANCE: invention refers to a compound having general formula (I),

where: m and n are independent integer numbers of 1 to 6; each of X1-X3 and Y1-Y3 is O; each of R1-R3 is independently chosen from a group consisting of hydrogen or alkyl; and R is O-(CH2)x-C(-O)NR'-(CH2)y-NHR'. Besides, x and y are independent integer numbers of 1 to 6; and R' is chosen from the group consisting of hydrogen and alkyl. In addition, an antibody containing an antigen recognition area, use of the compound, pharmaceutical composition, use of the antibody, method for MMP-2 or MMP-9 activity inhibition in a sample and a composition for determining MMP-2 or MMP-9 are proposed.

EFFECT: invention allows obtaining compounds that are able to inhibit MMP-2 or MMP-9 activity.

11 cl, 16 dwg, 4 tbl, 11 ex

FIELD: chemistry.

SUBSTANCE: invention relates to molecular complexes of zinc and cadmium bis(1-phenyl-3-methyl-4-formyl-5-pyrazolonate) with amino-derivatives of nitric heterocycles of general formula (I) (NH2-Het)n, where NH2-Het is 1-aminoisoquinoline, 3-aminoquinoline, 6-aminoquinoline, 5-amino-4,6-dimethylquinoline, 2-aminopyridine, 2-amino-5-bromopyridine, 3-amino-5-methylisoxazole, 2-amino-1-ethylbenzimidazole, M is Zn, Cd, n=1, 2.

EFFECT: molecular complexes of formula (I) exhibit luminescent properties in the blue region of the spectrum and can be used as phosphors for making organic light-emitting diodes of white and visible light.

14 ex

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining complex solutions of copper acetylenides of general formula R-C≡C-Cu·3MX2, where R = alkyl, aryl; M = Mg, Ca; X = Cl, Br, I. Complex solution of said copper acetylenides is prepared by boiling for 1.5-2 hours in flow of inert gas of mixture, consisting of copper protoxide (Cu2O), water-free salt of alkali earth metal MX2, where M = Mg, Ca; X = Cl, Br, I, and alkyne of general formula R-C≡C-H, where R=alkyl, aryl, in molar ratio:Cu2O : MX2 : alkyne = 1.1:3:1 in bipolar aprotic solvent (H,H-dimethylformamide, N,N-dimethylacetamide) in presence of catalytic quantity of triethylamine.

EFFECT: invention makes it possible to exclude stage of preparing explosive copper acetylenides and simplify technology.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to producing biologically active substances and concerns a method for preparing a chelate amino acyl calcium complex consisting in preparing solutions of glycin and calcium salt in the mole ratio Ca2+: glycin - 1:2; the prepared solutions are mixed and incubated for at least two hours, then frozen at temperature -70°C, and then dried in low-temperature vacuum.

EFFECT: method is characterised by ease implementation and low time span time.

The invention relates to a method for Organoelement compounds, which can be used as additives to lubricating oils

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining complex solutions of copper acetylenides of general formula R-C≡C-Cu·3MX2, where R = alkyl, aryl; M = Mg, Ca; X = Cl, Br, I. Complex solution of said copper acetylenides is prepared by boiling for 1.5-2 hours in flow of inert gas of mixture, consisting of copper protoxide (Cu2O), water-free salt of alkali earth metal MX2, where M = Mg, Ca; X = Cl, Br, I, and alkyne of general formula R-C≡C-H, where R=alkyl, aryl, in molar ratio:Cu2O : MX2 : alkyne = 1.1:3:1 in bipolar aprotic solvent (H,H-dimethylformamide, N,N-dimethylacetamide) in presence of catalytic quantity of triethylamine.

EFFECT: invention makes it possible to exclude stage of preparing explosive copper acetylenides and simplify technology.

2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to organometallic synthesis, specifically to a method for combined production of 2,3-dialkylmagnesacyclohept-2-enes of general formula (1), where R=C2H5, H-C3H7, H-C4H9, and 4,5-dialkylmagnesacyclohept-4-enes of general formula . The method includes reacting 2,3-dialkylmagnesacyclohept-2-enes with ethylene in the presence of a catalyst - zirconocene dichloride Cp2ZrCl2 under excess ethylene pressure of 1.0-1.5 MPa with molar ratio of 2,3-dialkylmagnesacyclohept-2-ene:Cp2ZrCl2=10:(0.3-0.6). The method is carried out in a solvent mixture of diethyl ether and tetrahydrofuran, taken in volume ratio of 5:1, at temperature of about 20°C for 6-8 hours.

EFFECT: obtained compounds can be used as cocatalysts in oligomerisation and polymerisation of olefins, acetylene and dienes, and as initial reactants for synthesis of different bifunctional and heterocyclic compounds.

1 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing tertiary cyclic alcohols of the 2,2'-bithiophene series by reacting 5-bromo-2,2'-bithiophene or 5-iodo-2,2'-bithiophene and magnesium in absolute diethyl ether with a cycloalkane in molar ratio of 1:1:1 (for adamantanol 1:1:0.8), at temperature of 35-36°C for one hour.

EFFECT: simple process due to use of readily available reactants, use of an acceptable molar ratio of reactants, shorter overall duration of the reaction, low cost of production due to a simple reactor scheme.

2 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing a double isopropylate of magnesium and aluminium which is a starting compound for synthesis of nanodispersed powder of an aluminium-magnesium spinel, which can be used to produce transparent polycrystalline ceramics. The method involves reaction of isopropyl alcohol with magnesium and aluminium in the presence of an activator, followed by purification of the obtained product. The magnesium and aluminium are used in form of an alloy which contains not less than 32 wt % Mag and not more than 68 wt % Al, and the activator used is tin chloride in amount of not less than 0.1 wt % of the amount of the starting alloy in the presence of ammonium halides in amount of not less than 0.2 wt % of the starting alloy; the reaction is carried out with metered supply of alcohol into the top part of a tubular reactor which is heated to temperature of 80-200°C.

EFFECT: present invention enables to obtain the desired product with high purity using a simple, cheap and highly efficient method.

3 cl, 5 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention refers to photosensitisers, namely to a conjugate of RGD-containing peptide or RGD-peptidomimetic and a photosensitiser selected from tetraarylporphyrin of formula:

or chlorophyll or tbacteriochlorophyll of formulae , or wherein tetraarylporphyrin or said chlorophyll or bacteriochlorophyll derivative of formula I, II or III contains at least one residue of the RGD-containing peptide or RGD-peptidomimetic. The values of M and radicals is related with those specified in the patent claim. Also, there are offered a pharmaceutical composition, a diagnostic technique for tumours by dynamic fluorescent visualisation, molecular magnetic resonant tomography (MPT) for diagnosing tumours and a method of photodynamic therapy of tumours.

EFFECT: invention provides producing the conjugate of the RGD-containing peptide or RgD-peptidomimetic and the photosensitiser which is applied in methods of photodynamic therapy and diagnosing of tumours.

23 cl, 75 dwg, 43 ex, 5 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 2,4,6,8-tetraphenylmagnesacycloundecane of formula I: The method involves reaction of styrene with magnesacyclopentane in the presence of a catalyst - zirconocene dichloride Cp2ZrCl2, in a dry argon atmosphere. Molar ratio styrene: magnesacyclopentane: Cp2ZrCl2 = 10:(10-14):(0.3-0.5). The method is carried out in tetrahydrofuran at room temperature (about 20°C) for 12-20 hours.

EFFECT: invention enables to obtain 2,4,6,8-tetraphenylmagnesacycloundecane, which can be used in synthesis of heterocyclic and bifunctional compounds, as well as components for catalyst systems in oligo- and polymerisation of unsaturated hydrocarbons.

1 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 2,3,4,5-tetraalkylmagnesacyclopenta-2,4-dienes (I) of formula: (1), where R=C2H5, n-C3H7, n-C4H9, characterised by that reaction of 2,3,4,5-tetraalkylmagnesacyclopenta-2,4-dienes ( , where R=C2H5, n-C3H7, n-C4H9) with ethylene in the presence of zirconocene dichloride Cp2ZrCl2 takes place under ethylene excess pressure of 0.5-1.0 MPa, in molar ratio 2,3,4,5-tetraalkylmagnesacyclopenta-2,4-diene: Cp2ZrCl2=10:(0.3-0.6), in a mixture of diethyl ether-tetrahydrofuran or diethyl ether-dimethyl ether solvents, taken in volume ratio of 5:1, at temperature or approximately 20°C for 6-8 hours.

EFFECT: method enables to obtain the desired compounds with high selectivity.

1 cl, 9 ex, 1 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a complex of formula:

, with the following characteristics: MS (MALDI-TOF), m/z: 2259 [M]+, UV-VIS (pyridine) λmax/nm: 329; 785; 918, spectrum NMR1H (Py): δ 6.68-6.98 (m, HPh), 7.24-7.25 (m, HNph and HAr). A method of producing the complex is also disclosed.

EFFECT: obtaining a complex of the formula given above, having intense absorption in the near infrared region.

2 cl, 1 ex, 1 dwg

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