Method for estimation of thickness of retina nerve fibers peripapillary layer in persons with anomal refraction
SUBSTANCE: length of the anterior-posterior axis of the eye is measured. Using optical coherence tomography (OCT), the average thickness of the peripapillary layer of nerve fibers of the retina (RNFPL) is measured in mcm. At that, the average thickness of the RNFPL is measured on an OCT device. Then, the equivalent thickness of the RNFPL (E) is calculated in the emmetropic eye with an anterior-posterior axis length of 23.5 mm using a mathematical expression. With a value of E obtained below 84 mcm, the patient is considered to be at risk of development of glaucomatous or other atrophy of the optic nerve.
EFFECT: method allows early identificatio of individuals at risk of development of glaucomatous or other atrophy of the optic nerve among patients with refractive anomalies.
1 tbl, 2 ex
SUBSTANCE: examination of the area of the optic nerve disc by a method of optic coherent tomography is carried out. The thickness of a layer of peripapillary nervous fibres from 4 to 8 sector of a conventional clock face is determined. If the thickness of the layer of peripapillary nervous fibres in as minimum one of the sectors is lower than 34.81-35.84 mcm - in 4 sector, lower than 48.92-49.52 mcm - in 5 sector, lower than 67.76-68.56 mcm - in 6 sector, lower than 66.52-67.32 mcm - in 7 sector, lower than 32.98-33.76 mcm - in 8 sector, Huntington's disease is diagnosed. If the thickness of the layer of peripapillary nervous fibres in all segments in 4 sector is 34.81-35.84 mcm and higher, in 5 sector is 48.92-49.52 mcm and higher, in 6 sector is 67.76-68.56 mcm and higher, in 7 sector is 66.52-67.32 mcm and higher, in 8 sector is 32.98-33.76 mcm and higher, the absence of Huntington's disease in the patient is diagnosed.
EFFECT: method provides a possibility of disease express-diagnostics at a pre-clinical stage with high accuracy and specificity, provides a possibility of performing screening diagnostics of a large population of people aimed at early disease detection.
2 dwg, 3 ex
SUBSTANCE: ultrasonic diagnostic system of image formation for the analysis of the foetus heart contains a probe for forming of the three-dimensional image, user controls, movement estimation device responding to the signals reflected from the specified place, probe controller responding to the time gate signal, and display responding to sets of the three-dimensional data for forming of three-dimensional heart image. The probe is designed with a possibility of obtaining of data sets of the heart image of and reflected signals in M-mode from the selectively set M-line. The user controls are designed with a possibility of positioning of M-line cursor marking the movement location in anatomic structure on the ultrasonic image, which represents a palpitation cycle. The movement estimation device is designed with a possibility of processing of signals, reflected from M-line, for generation of time gate signal with reference to the palpitation cycle. The probe controller is designed with a possibility of instructing the probe to obtain the three-dimensional data sets in given phases of the palpitation cycle, as it is specified by the time gate signal, for forming of three-dimensional images. Meanwhile the foetus heart image is formed using two-dimensional or three-dimensional ultrasonic images. The M-line cursor is moved to the heart beating location. One-dimensional reflected signals in M-mode from the heart beating location are received. A gated data retrieval signal from the information on reflected signals against the background of heart beating is synthesized. The gated three-dimensional heart-related data sets, using a synthesized gated data retrieval signal are obtained. A sequence of dynamic three-dimensional heart images from the three-dimensional data sets is formed.
EFFECT: invention allows to obtain the images according to a cardial cycle of foetus without the need in additional image data arrangement.
14 cl, 9 dwg
SUBSTANCE: invention relates to medical diagnostic ultrasonic probes for obtaining a body image. A probe, scanning a three-dimensional area by the movement of a matrix converter, contains a case, which has a butt end nozzle with a compartment for liquid on a distal end and a handle below the distal end, the matrix converter, installed on a carriage unit in the compartment for liquid, a pair of guides, on which the carriage unit moves in the compartment for liquid, rollers, located on the said ends of the carriage unit, which include a roller, rolling on the top of the guides, and a roller, rolling inside the hollow of the guides, a cord, connected with the carriage unit, a rotatable cam, around which a cord is wound, with the cam being fixed on one axis to the cam shaft, passing from the bottom part of the cam into the handle, and an electric engine, located in the handle and operatively connected to the cam shaft to move the carriage unit and the matrix converter along the guides.
EFFECT: application of the invention makes it possible to increase the width of a view area in the near area in front of the probe.
12 cl, 6 dwg
SUBSTANCE: invention relates to medical systems of ultrasonic diagnostics with application of three-dimensional echogram data. System of ultrasonic diagnostic visualisation contains three-dimensional ultrasonic probe, tract of ultrasonic signal passage, connected to it display and unit of analytical processing of images, made with possibility of determining location of reference image in the set of data of three-dimensional images, manipulation with the set of data of three-dimensional images from projection of reference image, registration of manipulations with the set and reproduction of registered manipulations from projection of reference image. In the second version of system implementation display is made with possibility of displaying images of three different planes of visualisation of the set of data of three-dimensional images, with display being used for displaying images for unit of analytical image processing, which additionally includes possibility of performing one or several manipulations aimed at changing image plane, transfer of target centre of visualisation plane into other anatomical location, rotation of visualisation plane around the axis and transfer of visualisation plane on specified distance. Method of registration of analysis protocol for data of three-dimensional ultrasonic image in system of ultrasonic diagnostic visualisation consists in obtaining the set of data of three-dimensional images of specified anatomical structure, identification of reference image, registration of manipulations with image projection, provision of manipulation with projections of images of data of three-dimensional images, starting with projection of reference image and finishing with desired final projection of image, and termination of registration. After that, second set of data of three-dimensional images of anatomical structure of the same type is obtained, reference image of second set of data of three-dimensional images is identified; registration is reproduced to perform manipulation with projections of images of second set of data of three-dimensional images with termination with desired final projection of image.
EFFECT: application of invention makes it possible to give standardised protocol of three-dimensional analysis for submitting to analyst of any qualification level, possibility of automation for improvement of flow of three-dimensional analysis operations and reduce time for analysis.
11 cl, 7 dwg
SUBSTANCE: invention relates to means of measuring body volume in the process of ultrasound visualisation. Method of automatic composition of volume in system of ultrasound visualisation contains stages, at which set of data of 3-dimensional object image is collected; user selects first surface of interest in the data of 3-dimensional image, with said first surface containing first cut of object; main axis of first cut on first surface of interest is automatically determined, first set of planes from the data of 3-dimensional image is specified, with said planes not being parallel to main axis of first cut, however being parallel to each other with specified distance between two successive planes along main axis; contour of each second cut is automatically drawn for, at least, two planes from first set of planes, each of which contains respective second cut of object; automatic composition of object volume is carried out by superposition of contours drawn in two planes from first set of planes along main axis and by placement of planes at specified distance. Method of calculating volume in ultrasound system includes composition of object volume, with each plane from set of planes being perpendicular to main axis of first cut, after which partial volumes, contained between two successive planes in set of planes on main axis of first cut are calculated and summed up. Device for method realisation contains means for collecting set of the data of 3-dimensional image by means of ultrasound, means of displaying, at least, image of first cut of object, means of selection by user of first surface of interest in the data of 3-dimensional image, means for determination of main axis of first cut of object on surface of interest, means of specifying first set of planes from the data of 3-dimensional image, means of drawing in, at least, two planes from first set of planes, each of which contains respective second cut of object, contour of each second cut, and means of object volume composition. Composition of device also includes computer-readable carriers, whose software contains commands for realisation of methods.
EFFECT: application of invention makes it possible to increase accuracy of volume determination and reduce human interference in the process of measurement.
15 cl, 6 dwg
SUBSTANCE: invention relates to medical equipment, namely to systems of diagnostic visualisation with ultrasound. Method lies in introduction of contrast-enhancing preparation into monitored tissue, obtaining, during period of preparation action, support 3D CEUS volume and information of monitoring and picture in real time of monitored tissue, formation of multiplanar picture reconstruction of (MPR) with contrast enhancement (CEUS), for one of obtained pictures in real time, representation of obtained picture in real time, showing instrument within required part, and corresponding picture MPR CEUS for interventional navigation, after expiration of the period of contrast enhancement action. In the second version of method picture MPR CEUS is spatially registered with corresponding obtained images in real time. In the third version of method implementation maximal intensity projection (MIP) is formed as function of, at least, obtained 3D CEUS volume and information of monitoring and pictures in real time and is represented with instrument within required part. System contains ultrasound scanner, made with possibility of introduction of contrast -enhancing preparation into monitored tissue, obtaining support 3D CEUS volume and information of monitoring and formation of corresponding multiplanar picture reconstruction (MPR) with contrast enhancement (CEUS), and representation device, connected with it for representation of obtained pictures in real time.
EFFECT: application of the invention makes it possible to increase accuracy of aiming in interventional procedures without necessity to change course of work or switch to other module of visualisation.
20 cl, 4 dwg
SUBSTANCE: invention relates to medical equipment, namely to systems and methods of image formation in diagnostics of biological objects. System contains laser for generation of photoacoustic signals, converter, channel of ultrasonic signal, channel of photoacoustic signal, unit of movement assessment and unit of combination of images. Method of combination of sample images, which applies claimed device lies in sample illumination by illumination system, transmission of ultrasonic waves into sample by ultrasonic converter, generation of assessment of movement from ultrasonic signals, received at different moments of time from the same sample location, generation of photoacoustic image from received photoacoustic signals and its correction due to movement, with application of movement assessment.
EFFECT: method makes it possible to carry out precise matching of images, eliminate artefacts and improve recognition of elements in application of photoacoustic image formation in combination with ultrasonic formation.
17 cl, 2 dwg
SUBSTANCE: invention relates to medical equipment, namely to diagnostic systems and methods of ultrasonic visualisation. Transvaginal ultrasonic sensor contains elongated case, which includes tip section, intermediate section and base section. Within the limits of case tip section placed is holder with installed on it two-dimensional phased lattice of converter of elements and travel mechanism. Holder has axis of travel, oriented perpendicularly to longitudinal case axis. Two-dimensional phased lattice transmits and receives acoustic waves within three-dimensional spatial area, located before tip section, and is made with possibility of rotation around travel axis. Travel mechanism transfers converter holder along trajectory of hinged rotation in such a way that regulated desirable from clinical point of view vision field is obtained. Method of performing ultrasonic diagnostic visualisation includes techniques of work with ultrasonic sensor.
EFFECT: application of the invention makes it possible to increase efficiency of data collection in clinical conditions and improve characteristics of diagnostic visualisation.
13 cl, 3 dwg
SUBSTANCE: invention refers to medical equipment, namely to tissue thermal therapy devices. The device comprises a power emitter attached to a holder, and a manipulator comprising a manipulator transmission unit incorporating a hanger body, a transmission drive unit comprising a drive element, and a holder hanged onto the hanger body. The manipulator transmission unit has a first sub-unit for moving and rotating the hanger body in a surface parallel to a support surface, as well as a second sub-unit for moving the power emitter along a focusing axis and for rotating the emitter about two various axes perpendicular to the focusing axis. The hanger body comprises remote portion; the first sub-unit comprises movably guided supports and support guides. Each of the remote portions is rotated and coupled with the movably guided support which is supported by the support guide. A magnetic resonance imager is provided with the tissue thermal therapy device.
EFFECT: use of the invention enables precise positioning and orientation of the power emitter providing five degrees of freedoms.
16 cl, 16 dwg
SUBSTANCE: invention relates to medical equipment, namely to visualisation devices. Device for installation into required position of ultrasound converter for ultrasound therapy with focusing of processing beam contains three fixing devices of ultrasound converter, three telescopic constructions with connecting elements and drive device for independent bringing into motion of each telescopic construction towards patient or from them for ultrasound converter travel within three degrees of freedom. Device components are made from non-magnetic materials. Device is included into the first version of implementation of system for medical processing. The second version of system for medical processing additionally includes device for visualisation of a section of patient which is of interest in zone of visualisation and support for patient. Device for installation is supported by means of support for patient, and visualisation device includes information-processing component, which superposes ultrasound beam image on diagnostic images. The third version of system implementation additionally contains drive device for installation of ultrasound converter into required position with provision of five degrees of freedom. Method of installing ultrasound beam in required position for processing of target section of patient by means of high intensity focused ultrasound of (HIFU) includes initial installation of ultrasound beam with provision of five degrees of freedom, processing, obtaining information, which characterises tissues on the section of interest, and its temperature profile, re-installation of ultrasound beam on the basis of obtained information and continuation of processing.
EFFECT: application of invention makes it possible to facilitate positioning of ultrasound converter with minimisation of impact which elements of travel exert on magnetic field inside patient.
22 cl, 12 dwg
SUBSTANCE: light sensitivity of retina is determined in 29 points of macular area by method of microperimetry under control of auto-tracking. If value of light sensitivity in 29 points constitutes more than 17 dB, then prediction of pleoptic treatment of amblyopia is favorable. If average value of light sensitivity constitutes from 15.6 dB to 17 dB including, then prediction of treatment is relatively favourable. If average value of light sensitivity constitutes less than 15.6 dB, then prediction of treatment is unfavourable.
EFFECT: method makes it possible to make acute prediction of efficiency of pleoptic treatment of children and teenagers, determine preservation of visual functions due to optimal prediction method, ensures obtaining reliable data of retina light sensitivity, independent on patient's fixation stability due to application of microperimetry under control of auto-tracking.
SUBSTANCE: localisation of boundaries of the optic nerve disk on a digital image of the eye fundus, is performed. In ranges of the localised zone of the optic nerve disk an analysis of the spatial distribution of blue colour areas is carried out. If the blue colour areas are located pointwise on the lines, parallel to the vertical axis, each area with the size from 1 to 6 pixels, with the quantity of areas being over 300, then a neoplasm of the optic nerve is diagnosed.
EFFECT: method ensures the non-invasive and reliable diagnostic of the optic nerve neoplasms of due to the analysis of a spatial distribution of peculiarities of the areas, in which blue colour components, typical only for the given type of pathology, are detected.
4 dwg, 1 ex
SUBSTANCE: method applies a visual system of depth-effect 2D image perception; ocular movements are recorded by a binocular eye-tracker; right and left eye lines are sensed. At the first stage: Io image is selected, wherein the person being tested perceives image relief and depth effects. The Io is displayed on a monitor screen of the binocular eye-tracker, spaced from the eyes at 0H; a right (Ra) and left (Le) eye line X-coordinate array is recorded during the period ΔT of measurement. A coordinate difference is calculated by formula ΔX=LeX-RaX; a coordinate difference histogram is contoured; a difference histogram contour peak is localised as a peak density of eye focusing planes, a contour line range, and focusing planes. A distance maxH to the difference histogram contour peak is calculated on the left lH and right rH contour lines; provided maxH≠0H, then the differences ΔH=lH-rH are derived, and objective physiological makers of the relief effect that are the parameters independent of an estimation offered by the person being tested and recorded by the binocular eye-tracker are detected. They are compared to a relief analogue that is a 3D-pixel image perception depth 3DIo. A coordinate difference 3DΔX is calculated; a difference histogram is contoured; a difference histogram contour peak is localised as a peak density of eye focusing planes, a contour line; a distance 3DmaxH to the contour peak and the eye focusing plane, and the contour line is measured. Provided the distances 3DmaxH, 3DΔH fall within the distance range ΔH=lH-rH≠0, with maxH≠0H, general physiological principles of the relief effect perception and the depth perception of the pixel images between 3DIo and Io are stated. They are referred to reference plane images IR, which describe positions of the right and left eye focusing planes within the distance range ΔH=lH-rH≠0, with maxH≠0H. The second stage involves drawing independent samples of the people being tested who are presented with the reference plane images IR formed at the first stage. Relief build-up values are derived on the images IR, statistical relief tracking diagrams on the analysed images are constructed. The relief perception for independent samples of the people being tested is matched, and the general principles of the plane image relief perception are laid down.
EFFECT: method enables identifying the principles of unconscious perception of the image relief perception by recording the eye motions by the binocular eye-tracker.
5 dwg, 1 ex
SUBSTANCE: method includes, on a horizontal area using an optical method, forming strips of light with an arbitrary shape and width, which randomly move on the area while passing through its centre; placing the test subject at the centre of the area, evaluating movement of the strips of light and jumping over said strips such that take-off points and landing points are as close as possible to corresponding boundaries of the jumped over strips of light; recording movements of the strips of light and the test subject; determining distance from the take-off points and landing points of the test subject to corresponding boundaries of the jumped over strips of light; calculating arithmetic mean values and mean-square deviation of the distance from the take-off points and landing points of the test subject to corresponding boundaries of the jumped over strips of light; based on the calculated arithmetic mean values and mean-square deviation, determining motor capabilities of the test subject and accuracy thereof.
EFFECT: method enables to evaluate human motor capabilities using instrumental examination.
SUBSTANCE: invention refers to medicine, namely to ophthalmology, and can be used for assessing the effectiveness of pigment granule photothermolysis in trabecular membrane cells following laser trabeculoplasty. A method consists in detecting trabecular membrane pigmentation at least one month following the laser trabeculoplasty. A colorimetric analysis is used for the process of detection. That is ensured by performing a single photorecording of the trabecular membrane at 10x to 40x magnification. Both laser exposed and non-exposed sites are photorecorded. That is followed by evaluating the colorimetric analysis results R, G, B of these sites in Paint drawing editor to be compared. Pigmentation intensity variations of the trabecular membrane are evaluated.
EFFECT: method provides high assessment accuracy and objectivity of the pigment granule photothermolysis in the trabecular membrane cells by the optimum comparison environments of both laser exposed and non-exposed membrane sites.
1 dwg, 1 ex
SUBSTANCE: ultrasonic biomicroscopy is used to measure the distance of the lens and corneal endothelium and the distance of the trabecule and iris in the lying and sitting patient. A difference of 0.5 mm and more of the lying and sitting distances of the lens and corneal endothelium is detected. A difference of 0.1 mm and more of the lying and sitting distances of the trabecule and iris is detected. The detected distance differences testify to the presence of degree I latent dislocation of the lens.
EFFECT: reliable and precise pre-operative detection of degree I latent dislocation of the lens ensured by a possibility to measure the depth variations of the anterior eye chamber, iris-lens diaphragm shift, ligament instabilities accompanying postural changes.
SUBSTANCE: device for conjunctival microscopy comprises an optical system with an integrated power supply accommodating a video camera with an image transfer system, a light unit and a computer-based image control, recording and analysis system, a wireless coupling unit configured to maintain dynamic feedback between the optical system and the control unit. The light unit comprises two high-brightness white light-emitting diodes rigidly attached to a video camera so that their light flux direction makes an angle of not less than 20° in relation to an optical axis of the image transfer system. The wireless coupling units of the optical system and analyser comprises a wireless image transmission element, an image characteristics wireless transmission element, a light characteristics wireless control element and a wireless notification canal element. The wireless coupling unit of the optical system, video camera and notification unit are connected to the supply unit of the optical system.
EFFECT: using the given invention enables reducing the diagnostic time and increasing reliability for assessing the patient's state.
SUBSTANCE: total visual field degrees, intraocular pressure and maximum visual acuity in a patient suffering glaucomous optic neuropathy, and a risk of progressing glaucomous optic neuropathy is predicted by formula: y=25.8+10.9x1-0.002x2-1.5x3, wherein y is a prognostic index, x1 is a maximum visual acuity, x2 is total visual field degrees, x3 is an intraocular pressure. If observing y=1.73 and less, a high risk of progressing glaucomous optic neuropathy, i.e. for 6-8 months following the examination is stated; if observing y=1.74-4.99, a moderate risk, i.e. for 9-12 months following the examination, is determined; the value y=5.00 and more shows a low risk of glaucomous optic neuropathy, i.e. the beginning of progressing for 13-24 months following the examination.
EFFECT: method enables predicting the risk of progressing glaucomous optic neuropathy to provide well-timed prescription of the neuroprotective treatment by the ophthalmological examination.
5 tbl, 2 ex
SUBSTANCE: two light spots are formed on a horizontal surface by light emitters controlled by a computer. A test subject is placed at the middle of a line passing through the centres of the light spots. The area, colour, brightness, direction and speed of movement of the light spots are varied according to a program over a given period of time unpredictably for the test subject. The test subject evaluates transformation and movement of the light spots and changes their position in order to remain at the middle of the line passing through the centres of the light spots. Transformation and movement of the light spots and the test subject are recorded by a video camera situated at a given height over the horizontal surface. The video image is transmitted to the computer. From the moment of changing the area or colour or brightness of direction or speed of movement of the light spots, the computer periodically calculates, with a given period, the position of the middle of the line passing through the centres of the light spots, and the centre of the location of the test subject, the distance between the middle of the line passing through the centres of the light spots and the centre of the location of the test subject, the arithmetic mean of the calculated distances. The capacity of the test subject to judge distance is evaluated based on the arithmetic mean.
EFFECT: method improves the accuracy of evaluating the capacity of a person to judge distance based on results of collaborative operation of the visual, vestibular and muscular analysers and the motor apparatus of the person.
SUBSTANCE: three or more light spots are formed on a horizontal surface by light emitters controlled by a computer. A test subject is placed at the centre of a loop enveloping the light spots. The shape, area, colour, brightness, direction and speed of movement of the light spots are varied according to a program over a given period of time unpredictably for the test subject. The test subject evaluates transformation and movement of the light spots and changes their position in order to remain at the centre of the loop enveloping the light spots. Transformation and movement of the light spots and the test subject are recorded by a video camera situated at a given height over the horizontal surface. The video is transmitted to the computer. From the moment of changing the shape or area or colour or brightness of direction or speed of movement of the light spots, the computer calculates, periodically with a given period of time, the position of the centre of the loop enveloping the light spots and the centre of the position of the test subject, the distance between the centres, the arithmetic mean value of the calculated distances between the centre of the loop and the centre of the position of the test subject. The capacity of the person for perception and orientation in space is then evaluated based on the arithmetic mean value.
EFFECT: method improves the accuracy of evaluating the capacity of a person for perception and orientation in space based on results of collaborative operation of the visual, vestibular and muscular analysers and motor apparatus of the person.
SUBSTANCE: method involves introducing drug under study into conjunctival sack or in periocular way. Multiple dynamic recording of general electroretinogram is carried out. Maximum DRUG concentration in retinal tissue is estimated from time difference of Tmax eff and T0, where Tmax eff is the time for reaching maximum amplitude value of b-wave. Drug half-removal time T1/2 is calculated as difference of T1/2max eff and T0, where T1/2max eff is the time the b-wave amplitude is 50% reduced when compared to maximum. T0 is the initial b-wave amplitude recording time.
EFFECT: high accuracy in estimating drug properties.
3 cl, 4 dwg