Methods of medical active agent delivery by injection of individual health articles containing filament

FIELD: medicine, pharmacy.

SUBSTANCE: invention refers to medicine and is represented by methods of medical active agent delivery to a mammal. The method includes a stage when the medical article comprising one or more filaments, consisting of: base material of 10-50% by weight, based on dry filament, selected from natural polymers, synthetic polymers, sugars and combinations thereof; medical active agent of 50% by weight, based on dry filament, and moisture less than 20% by weight based on filament, is injected to a mammal. Filaments are obtained by meltdown blowing or by forming liquid film fibers and constitute a nonwoven fabric with a surface density of 20-1000 g/m2. The medical active agent is able to be released from the nonwoven fabric when it is exposed to the conditions of target application.

EFFECT: invention delivers higher levels of medical active agents to a mammal.

12 cl, 4 dwg, 7 ex

 



 

Same patents:

FIELD: food industry.

SUBSTANCE: protein produced of milk is plasticised together with a plasticiser at a temperature of 60°C - 140°C under mechanical stress conditions; then fibres are moulded by means of a draw die. The plasticiser is chosen from the group including a polysaccharide water solution, glycerine, ethylene glycol or these substances mixture.

EFFECT: produce fibres have significant tensile strength.

13 cl, 1 tbl, 3 dwg, 1 ex

FIELD: process engineering.

SUBSTANCE: invention relates to production of nanofibres by electrostatic process. Spinning fibre-forming electrode designed to carry polymer solution or melt in electric field for fibre forming in devices intended for fibre forming by electrostatic process from said solutions or melts. Said electrode features elongated shape and comprises two end parts arranged at carrier. Fibre-forming elements made of string or wire bar are laid between said two parts. In compliance with this invention said fibre forming electrodes are inclined to axis of spinning of said electrode.

EFFECT: no sputter of polymer solution or melt.

8 cl, 4 dwg

FIELD: process engineering.

SUBSTANCE: invention relates to production of several synthetic threads to be stretched and wound and to device to this end. Note here that synthetic threads are formed parallel with each other, cooled and tightened by extrusion of thin bundles of filaments. Note also that said threads are stretched as a bundle of threads are wound on reels. To allow identical physical conditions, threads after extrusion and before stretching are pulled off independently by separate godet wheels. This allows identical conditions of extrusion, cooling and stretching of every thread. Proposed device comprises several separate godet wheels arranged side by side and ahead of stretching device relative to one of the threads. To pull off a definite thread, said godet wheels can actuate an appropriate drive.

EFFECT: higher efficiency.

12 cl, 4 dwg

FIELD: chemistry.

SUBSTANCE: water composition contains in wt % 15-40 solution of interpolymeric complex, 50-80 aqueous solution of thickening agent (concentration 8 - 14%) and acidity regulator 2H HCl to pH=2 - 4. Interpolymeric complex is obtained by mixing 1% solution of polyacrylacid and 10% solution of polyvinyl alcohol with component ratio 1:1. As thickening agent, applied is polyvinyl alcohol or polyethylenoxide. Viscosity of composition constitutes from 0.5 to 0.9 Pa·s.

EFFECT: application of claimed spinning composition makes it possible to obtain fibres with diameter 200 - 400 nm with high indicators of hygroscopicity and steam-permeabilityat quite fast rate.

1 tbl, 3 ex

FIELD: process engineering.

SUBSTANCE: invention relates to production of strands of composite material by combining continuous glass fibers with continuous fibers of organic high-shrinkage material used as reinforcing material. Thermoplastic fibers, stretched and heated to softening point, are thrown on revolving drum 17 at the rate exceeding operating rpm of said drum. Web 10 of said thermoplastic fibers are mixed on drum surface with glass fiber bundle or web 2 to make composite material strand. Said drum 17 has multiple holes and element 19 dividing drum inside into, at least, two compartments, one with rarefaction to keep thermoplastic fibers in initial crimp state and another one with increased pressure to separated web from drum surface. Produced strand features uniform distribution of fibers and stable properties.

EFFECT: composite material with liner glass fibers and crimped thermoplastic fibers.

8 cl, 2 dwg

FIELD: polymer chemistry.

SUBSTANCE: invention refers to the devices for thread cooling during formation of thermoplastic materials for manufacturing of monofiber thread of fleece or fiber out of polymer materials, i.e. polypropylene. The device includes tank (1) made with possibility of running water supply and elements (2) of thread direction with cuts (3) for thread placements. The elements (2) of thread direction are made of elastic hygroscopic material and are established with possibility of filling the material with water from the tank (1) for thread cooling. The cuts (3) for thread placement are made as cuts in elastic hygroscopic material.

EFFECT: decrease of defects due to reduced probability of thread tearing during cooling with decreased size of cooling unit.

6 cl, 2 dwg

FIELD: machine-building industry.

SUBSTANCE: device comprises a shaping device, treatment device and pick-up device which are stacked one above the other making a number of positions for one or several filaments production on each of the devices along longitudinal side of the machine. Besides, the platform of provided for process positions servicing. It is located along longitudinal side of the machine at the level between treatment device and pick-up device so that all necessary filament charging operations or device service operations could be done.

EFFECT: improved maintainability of device and reduced number of man-hours.

10 cl, 5 dwg

FIELD: textile, paper.

SUBSTANCE: method for fibrous material production consists in short-term treatment of polystyrene or its wastes in reactor with air or steam and air mixture with steam content of 50% vol. at the temperature of 90-120°C, pressure of 3 MPa for 30 seconds.

EFFECT: simple, efficient and ecologically pure method is developed for production of fibrous material from polystyrene or its wastes with high yield and good sorption properties.

9 ex, 1 tbl

FIELD: machine building.

SUBSTANCE: line consists of extruder, of unit of first broach, of device for thread cooling, of thread directing elements, of unit of second broach and of cut-off mechanism. Also, the line consists of a directing support element. The cut-off mechanism is positioned behind the support element. The thread cooling device is installed between the unit of the first and the second broach. Thread is laced-up S-like into upper and lower rollers in the first unit of broach. The upper roller is driven. The elements of thread direction in the device of thread cooling transfer thread in linear motion through the unit of the second broach and the directing support element to the cut-off mechanism.

EFFECT: arrangement of compact lines of high efficiency for fabrication of qualitative fibre.

12 cl, 8 dwg

FIELD: machine building.

SUBSTANCE: installation is designed for production of fibres out of thermo-plastic by means of supplying polymer melt and/or mixtures of polymers inside heated rotating fiberisator, in forming and simultaneous pulling fibres from jets of melt. The installation consists of an extruder, fiberisator, transporter for fibre collection, system for control and adjustment of temperature in the fiberisator; the system includes an optical pyrometre, power source and inductor. Notably, the rotating vertically installed fiberisator heated from the inductor is made in form of a cylinder with internal surface formed with a truncated cone, where angle between a shaft axis and an internal wall of the fiberisator is not less 30° and not more 35°, and with a lower truncated cone of the fiberisator where angle between a vertical axis of the fiberisator and cone generatrix is 45-60°. In a bottom part of the fiberisator and along circumference there are made openings; melt of thermo-plastic material flows via the openings under effect of centrifugal forces at fiberisator rotation. Angle of incline of secant flow of air from the opening of the inductor relative to vertical axis of the fiberisator is not less 10° to facilitate air flow directing formed fibre to a side opposite to the fiberisator. Diametre of produced fibre is adjusted by velocity of rotation and temperature of fiberisator walls, while output is determined with diametre and number of the openings in the fiberisator.

EFFECT: upgraded quality and physical-mechanical properties of produced fibre and reduced losses of source raw material due to destruction.

4 cl, 3 dwg, 1 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a technology of obtaining fibres from polymers based on polyacrylonitrile-polyacrylonitrile (PAN) and acrylonitrile (AN) copolymers, namely to a stage of a polymer separation from a solution, and can be applied in the production of materials for the textile industry and precursors for obtaining highly strong carbon fibre of a novel quality, applied in different fields of technology. The method of separating the polyacrylonitrile-based polymer from 15-22 vol% solution in the formation of a PAN-precursor for obtaining the carbon fibres includes the extraction of the polymer from its solution without the application of precipitators and the following removal of a solvent by the ventilation of the fibre by air jet. Separation of the polymer from the solution is realised under an influence of mechanical tensions at a temperature of 150°C lower than the temperature of the solvent boiling, with 8-12-time extraction until the freshly formed fibre, with a residual content of the solvent not more than 1%, is obtained.

EFFECT: considerable acceleration of the fibre formation, sharp simplification and acceleration of the polymer separation process, exclusion of a necessity of a multi-stage extraction of the fibre, simplification of the solvent regeneration process.

1 tbl, 3 ex, 2 dwg

FIELD: process engineering.

SUBSTANCE: invention relates to production of nanofibres by electrostatic process. Spinning fibre-forming electrode designed to carry polymer solution or melt in electric field for fibre forming in devices intended for fibre forming by electrostatic process from said solutions or melts. Said electrode features elongated shape and comprises two end parts arranged at carrier. Fibre-forming elements made of string or wire bar are laid between said two parts. In compliance with this invention said fibre forming electrodes are inclined to axis of spinning of said electrode.

EFFECT: no sputter of polymer solution or melt.

8 cl, 4 dwg

FIELD: technological processes.

SUBSTANCE: device for production of 2D or 3D fibre materials from microfibres or nanofibres comprises a set of metal spinning nozzles (3), connected with the first potential, a set of electrodes (6) of a collector facing the set of nozzles (3), arranged at regular intervals and connected with the second potential, and a collecting plate (7) or a collecting cylinder (14) for collection of microfibres or nanofibres laid between pairs of adjacent electrodes (6) of the collector. The substance of the invention consists in the following: a set of collector electrodes (6) comprises at least two electrodes (6) of the collector, arranged in one plane, and the collecting plate (7) on the line of its crossing or along the tangent to the collected cylinder (14), which is perpendicular to the line of contact with the plane of the collector electrodes (6), forming with the plane of the collector electrodes (6) an angle α in the range between 0° and 90°, at the same time the collecting plate (7) or the collecting cylinder (14) may move relative to the electrodes (6) of the collector in the direction in the plane that is perpendicular to the plane of collector electrodes (6), and where the axis of the electrode (6) lies in direction of movement of the collecting plate (7) or the collecting cylinder (14), forming with the axis of this electrode (6) the angle β, the value of which lies between 0° and 90°.

EFFECT: device makes it possible to create large flat and volume objects from ordered nanofibres.

9 cl, 14 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to method of spinning fibre, containing polypeptide polymer, as well as to products, including said polymer fibre. Method of fibre spinning includes draft of fibre from dope solution, containing polymer, preferably silk polypeptide which can be introduced into water solution with concentration constituting at least 0.15 mg/ml, polyacrylamide (PAA), which increases longitudinal viscosity of dope solution, and solvent. Invention makes it possible to obtain fibres, including living and non-living biological material, which could perform function of framework material for fabric engineering and growing artificial organs.

EFFECT: application of PAA in dope solution results in obtaining smooth and homogeneous fibres, non-biodegradable and long-lasting, in addition, application of very low concentrations of polymers and/or very low concentrations of improvers of PAA longitudinal viscosity facilitates spinning of fibres from dope solution.

24 cl, 4 dwg, 7 ex

FIELD: chemistry.

SUBSTANCE: invention relates to technology of obtaining ultrathin polymer fibres by method of electrospinning and can be used for spinning non-woven porous fibrous materials, applied as separating partitions, for instance, for filtration of gases and liquids, for manufacturing diffusion partitions, separators of chemical sources of current, etc. Solution for spinning contains 2.5-4 wt.p. of phenolformaldehyde resin, 2.5-4 wt.p. of polyvinyl butyral, 92-95 wt.p. of ethyl alcohol and as modifying additives 0.02-0.2 wt.p. of tetrabutylammonium iodide or 0.01-0.1 wt.p. of lithium chloride.

EFFECT: invention provides increase of solution electroconductivity, increased output of ultrathin fibres with diameter less than 0,1 mcm.

1 tbl, 7 ex

FIELD: chemistry.

SUBSTANCE: method and apparatus for producing fine fibres via fibre electrospinning by applying an electric field between a primary electrode and a counter electrode lying at a distance from the primary electrode and often parallel thereto. The working surface of the primary electrode is coated with a polymer solution. An electric field is created between the primary electrode and the counter electrode having sufficient strength to cause formation of fine fibres in the space between the electrodes. The working surface of the primary electrode coated with a polymer solution consists of corresponding parts of surfaces of a plurality of elements that are semi-submerged in the working state and are freely lying (not connected to anything), said elements resting at the bottom of a bath or tray or some other supporting structure(s). A tool is used, which enables to apply the polymer solution on the surface of the freely lying elements protruding from the solution via rotation thereof in the polymer solution, such that their surface is coated with a thin layer of the polymer solution.

EFFECT: method and apparatus according to the present invention enable to perform spinning with high efficiency while eliminating problems encountered in the previous technological level.

12 cl, 8 dwg

FIELD: medicine.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents artificial dura mater, produced from electrospinning layers by technology of electorspinning, with electrospinning layer, consisting of, at least, hydrophobic electrospining layer, which is produced from one or several hydrophobic polymers, selected from polylatic acid and polycaprolactone.

EFFECT: invention ensures creation of artificial dura mater, which has good tissue compatibility, anti-adhesiveness and possibility of introducing medications, preventing cerebrospinal fluid outflow during regeneration of person's own dura mater.

30 cl, 7 ex, 11 dwg

FIELD: chemistry.

SUBSTANCE: electrostatic field is formed in fibre-forming space between the fibre-forming element of a fibre-forming electrode, which is connected to one terminal of a high-voltage source and is located in a fibre-forming position, and a precipitation electrode connected to the second terminal of the high-voltage source to which a polymer matrix is fed from a reservoir with the matrix in an electrostatic field for forming fibre on the surface of the fibre-forming element of the fibre-forming electrode, wherein temperature of the fibre-forming elements of the fibre-forming electrode is raised higher than ambient temperature by direct contact heating of the fibre-forming elements.

EFFECT: more technologically effective method, and simple and efficient design of the apparatus.

8 cl, 2 dwg

FIELD: electricity.

SUBSTANCE: method includes spinning of electroconductive solution of organic and non-organic polymers and predecessor of organic polymer in presence of electric field between tip and earthing source till composite fiver is received. At that organic and non-organic phases of composite fibres are mixed and react with each other with production of -Si-O-M- links, where M is selected from the group consisting of Si, Ti, Al and Zr. The author offers composite fibre received by the above method and composite product including polymer matrix and composite fibres introduced to it.

EFFECT: improvement of method.

28 cl, 2 dwg, 1 tbl, 5 ex

FIELD: electricity.

SUBSTANCE: fibre electrospinning is carried out from an electroconductive solution of polymer in presence of electric field between a nozzle and a source of earthing. In the method realisation the polymer before and after electrospinning process is exposed to linking reaction. At the same time the polymer contains linked silane groups along the length of the main chain of polymer, and the linked groups react with water, including water contained in air. The fibre made according to the method of electrospinning contains links -Si-O-Si-.

EFFECT: using linking reaction before and during the process of electrospinning results in increased viscosity of polymer solution, making it possible to form the fibre and to reduce usage of thickeners to the minimum.

14 cl, 2 dwg, 1 tbl, 3 ex

Transdermal plaster // 2553350

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine. Described is matrix layer, suitable for application in plaster for transdermal delivery, aimed at introduction of biologically active compounds, which includes phosphate compound of tocopherol and polymer carrier. Also described is transdermal plaster and method of its production.

EFFECT: plaster makes it possible to efficiency introduce biologically active compounds.

48 cl, 15 tbl, 13 dwg, 12 ex

Up!