Method of producing hybrid two-phase system of delivery of poorly soluble and insoluble in water biologically active substances with controlled release kinetic

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutical industry, namely, to system of delivery of poorly soluble and insoluble biologically active substances (BAS) with controlled release kinetics, which is spherical nanoparticles containing hydrophobic core formed of biocompatible and biodegradable hydrophobic polymers, such as polyhydroxybutyrate, polylactide, polyglycolide, polydioxanone, poly-ε-caprolactone, polyhydroxyvalerate, copolymer of lactic and glycolic acids, in which there is a partially soluble or insoluble in water BAS; wherein hydrophobic core is surrounded with hydrophilic fragments of amphiphilic polymers consisting of one fragment of water-soluble carbon chain polymer with molecular weight Mn=1,000-30,000 Da and one end hydrophobic group, including one aliphatic radical with carbon atoms number in carbon chain 9÷20, as well as to method of producing such system of delivery.

EFFECT: group of inventions provides higher water compatibility of poorly soluble and insoluble BAS, increased stability of medicinal substances and possibility of controlling release rate of BAS.

6 cl, 7 ex, 6 tbl, 15 dwg

 



 

Same patents:

FIELD: measurement equipment.

SUBSTANCE: method for determining a range of sizes of suspended nanoparticles consists in passage of gas (mixture of gases) containing analysed particles, through diffusion batteries of a meshed type and their introduction to supersaturated vapours of a low-volatile enlarging substance. Then, lighting of a flux of particles with a light beam and recording of parameters of light signals shaped by enlarged particles at their flying through the pointed-out area of the flux is performed. In order to improve accuracy of determination of the range of sizes, the main flux is separated into six parallel fluxes. With that, five of them are passed through five diffusion batteries with a different slip, and one of them is passed directly. Then, these fluxes pass through six devices of condensation growth and then to a field of vision of a charge-coupled device matrix and the obtained six areas of images of enlarged fluxes of particles are transmitted to a computer for an analysis of their range of sizes. Unlike known ones, the method allows performing simultaneous processing by means of a computer of six images of enlarged particles, which characterise different dimensional ranges of nanoparticles.

EFFECT: reducing the time required for measurements and improving their accuracy.

1 dwg

FIELD: physics.

SUBSTANCE: semiconductor structure for photo converting and light emitting devices consists of semiconductor substrate (1) with face surface misaligned from plane (100) through (0.5-10) degrees and at least one p-n junction (2) including at least one active semiconductor ply (3) arranged between two barrier plies (4) with inhibited zone width Eg0. Active semiconductor ply (3) consists of 1st and 2nd type spatial areas (5, 6) abutting of barrier plies (3) and alternating in the plane of active semiconductor ply (3). 1st type spatial areas (5) feature inhibited zone width Eg1 < Eg0, while 2nd type areas have inhibited zone width Eg2 < Eg1.

EFFECT: higher efficiency owing to increased photo flux and higher level of photo generation and charge carrier separation, higher probability of photon generation and lower probability of radiation-free recombination.

11 cl, 11 dwg, 5 ex

FIELD: chemistry.

SUBSTANCE: first step includes obtaining low-hydroxylated insoluble fullerenols by reacting concentrated fullerene solution in o-xylene with aqueous ammonia solution in the presence of a tetrabutylammonium hydroxide phase-transfer catalyst at 35-40°C. At the second step, the obtained low-hydroxylated insoluble fullerenols are hydroxylated to transform them into a water-soluble form by mixing with 6-15% aqueous hydrogen peroxide solution and heating for 4-5 hours at 65°C. Water-soluble fullerenols are then precipitated from an alcohol-containing solution.

EFFECT: simplifying the method while preserving quality characteristics and full extraction of the end product.

2 cl, 1 dwg, 4 tbl, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to selenium nanocomposites of natural hepatotrophic galactose-containing polysaccharide matrixes, representing water-soluble orange-red powders containing zerovalent selenium (Se0) nanoparticles sized 1-100 nm in the quantitative content of 0.5 - 60 wt %, possessing antioxidant activity for treating and preventing redox-related pathologies, particularly for treating toxic liver damage, to a method for producing and to an antioxidant agent containing the above nanocomposites.

EFFECT: invention provides the targeted agent delivery to liver cells, as well as higher agent accessibility and lower toxic action of selenium.

7 cl, 11 ex, 4 tbl

FIELD: physics.

SUBSTANCE: method includes forming a near-field mask on the surface of a dielectric substrate and irradiating the obtained structure with a femtosecond laser pulse. The laser radiation is first passed through a nonlinear optical crystal with a coefficient of transformation into a second harmonic equal to 5-7%. The dielectric substrate coated with the near-field mask is irradiated with the obtained bichromatic femtosecond pulse with energy density in the range of 25-40 mJ/cm2, which is less than the laser radiation energy density normally used in similar nanopatterning.

EFFECT: high resolution and low laser radiation energy consumption.

6 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to a method for hydroconversion of heavy oil fractions - feed stock, the method including a zero step and subsequent N steps. The zero step includes feeding, into a reactor, material, a catalyst precursor - aqueous solution of a Mo (VI) salt or salts of Mo and Ni, and hydrogen at pressure of 4-9 MPa under normal conditions; reacting the material and hydrogen at 420-450°C in the presence of a precursor of a suspended nanosize molybdenum or molybdenum-nickel catalyst formed in the reactor; atmospheric or atmospheric-vacuum distillation of the hydrogenation product; removing the low-boiling fraction with a boiling point not higher than 500°C as a product and returning the high-boiling fraction or part thereof into the reactor. The next steps include feeding, into the reactor, material, a catalyst precursor, the returned part of the high-boiling fraction and hydrogen; reaction thereof; said atmospheric distillation of the hydrogenation product; removing the low-boiling fraction as a product; returning part of the high-boiling fraction into the reactor; burning at 1000-1300°C or gasification of the remaining part of the high-boiling fraction, after which trapped ash-slag residues are subjected to further oxidising burning at 800-900°C and the obtained ash product, which is carbon-free, is used to regenerate the catalyst precursor and produce an industrial concentrate of vanadium and nickel. The number of steps N is determined using formulae: bd(nn+nm+1)=a+i=1nmbi+benm, N=nn+nm+1, where nn is the number of steps with recirculation, after which equilibrium output of the low-boiling fractions is achieved; nm is the number of steps with recirculation after achieving equilibrium output of the low-boiling fractions, which enables to achieve a given output of low-boiling fractions from the feed stock; bd is the given output of low-boiling fractions, wt %; a is the output of low-boiling fractions at the zero step, wt %; bi is the output of low-boiling fractions at the i-th step before achieving equilibrium, wt %; be is the output of low-boiling fractions after achieving equilibrium, wt %, be>bd.

EFFECT: high output of low-boiling fractions, low molybdenum consumption, high degree of extraction of molybdenum, vanadium and nickel from the solution, enabling calculation of the required reactor volume, obtaining an industrial concentrate of vanadium and nickel, low hydrogen consumption.

3 cl, 1 dwg, 2 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention can be used in obtaining coatings, reducing coefficient of secondary electronic emission, growing diamond films and glasses, elements, absorbing solar radiation. Colloidal solution of nano-sized carbon is obtained by supply of organic liquid - ethanol, into chamber with electrodes, injection of inert gas into inter-electrode space, formation of high-temperature plasma channel in gas bubbles, containing vapours of organic liquid. High-temperature plasma channel has the following parameters: temperature of heavy particles 4000-5000K, temperature of electrons 1.0-1.5 eV, concentration of charged particles (2-3)·1017 cm3, diameter of plasma channel hundreds of microns. After that, fast cooling within several microseconds is performed.

EFFECT: simplicity, possibility to obtain nanoparticles of different types.

3 cl, 1 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to field of nanotechnologies and can be used for obtaining composite materials with high electric and heat conductivity, additives to concretes and ceramics, sorbents, catalysts. Carbon-containing material is evaporated in volume thermal plasma and condensed on target surface 9 and internal surface of collector 7. Plasma generator 3, which includes coaxially located electrodes: rod cathode 4 and nozzle-shaped output anode 5, are used. Gaseous carbon-containing material 6 is supplied with plasma-forming gas through vortex chamber with channels 2 and selected from the group, consisting of methane, propane, and butane. Bottom of collector is made with hole 8 for gas flow to pass.

EFFECT: invention makes it possible to reduce energy consumption of the process, extend types of applied hydrocarbon raw material, simplify device construction and provide continuity of the process and its high productivity.

2 dwg, 3 ex

FIELD: chemistry.

SUBSTANCE: method of obtaining a composite material includes the influence on a mixture of a carbon-containing material, filler and sulphur-containing compound by a pressure of 0.1-20 GPa and a temperature of 600-2000°C. As the sulphur-containing compound applied is carbon bisulphide, a compound from the mercaptan group or a product of its interaction with elementary sulphur. As the carbon-containing material applied is molecular fullerene C60 or fullerene-containing soot. As the filler applied are carbon fibres, or diamond, or nitrides, or carbides, or borides, or oxides in the quantity from 1 to 99 wt % of the weight of the carbon-containing material.

EFFECT: obtained composite material can be applied for manufacturing products with the characteristic size of 1-100 cm and is characterised by high strength, low density, solidity not less than 10 GPa and high heat resistance in the air.

11 cl, 3 dwg, 11 ex

FIELD: chemistry.

SUBSTANCE: invention relates to inorganic chemistry, namely to obtaining silicon-carbide materials and products, and can be applied as thermal-protective, chemically and erosion resistant materials, used in creation of aviation and rocket technology, carriers with developed surface of heterogeneous catalysis catalysts, materials of chemical sensorics, filters for filtering flows of incandescent gases and melts, as well as in nuclear power industry technologies. To obtain nanostructures SiC ceramics solution of phenolformaldehyde resin with weight content of carbon from 5 to 40% with tetraethoxysilane with concentration from 1·10-3 to 2 mol/l and acidic catalyst of tetraethoxysilane hydrolysis id prepared in organic solvent; hydrolysis of tetraethoxysilane is carried out at temperature 0÷95°C with hydrolysing solutions, containing water and/or organic solvent, with formation of gel. Obtained gel is dried at temperature 0÷250°C and pressure 1·10-4÷1 atm until mass change stops, after which carbonisation is realised at temperature from 400 to 1000°C for 0.5÷12 hours in inert atmosphere or under reduced pressure with formation of highly-disperse initial mixture SiO2-C, from which ceramics is moulded by spark plasma sintering at temperature from 1300 to 2200°C and pressure 3.5÷6 kN for from 3 to 120 min under conditions of dynamic vacuum or in inert medium. Excessive carbon is burned in air at temperature 350÷800°C.

EFFECT: obtaining nanostructured silicon-carbide porous ceramics without accessory phases.

4 cl, 4 dwg, 3 ex

FIELD: electricity.

SUBSTANCE: metal-dielectric structure and method of its manufacturing are related to electronic industry and electronic engineering and may be used both in modern energy-saving systems and components being an integral part of modern processors, in particular for development of microsized and nanosized electromechanical systems. The metal-dielectric structure consists of dielectric and conducting layers made as an assembly of capillaries filled with metals to the required length, at that conducting layers are etched on selective basis at different butt ends and metalised. The conducting layers are represented by two different types of electroconductive materials etched on selective basis at different butt ends, at that the conductive layers may be made of semiconductor materials, conducting glass, carbon nanoparticles and nanotubes while the dielectric layers may be made of optical and electron-tube glass, polymer materials. In cross-section the dielectric and conducting layers may be made as concentric circles. The manufacturing method for the above metal-dielectric structure includes assembly, overstretching, stacking to the unit, at that upon multiple overstretching vacuum filling with conducting materials is performed, and butt ends are etched on selective basis with different chemical composites and then they are metalised.

EFFECT: invention allows increasing capacitance and breakdown voltage for capacitors.

5 cl, 7 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to pressure sensitive adhesives, suitable for use on a wide variety of substrates, including both high surface energy and low surface energy substrates. Pressure sensitive adhesives comprise an acrylate polymer and surface-modified nanoparticles. The surface-modified nanoparticles comprise a nanoparticle comprising a silica surface and surface modifying groups, covalently bonded to the silica surface of the nanoparticle. At least one surface modifying group is a polymeric silane surface modifying group. At least one surface modifying group is a non-polymeric silane surface modifying group.

EFFECT: disclosure also provides a method of preparing pressure sensitive adhesives, including exposing them to UVA and UVC radiation.

21 cl, 2 dwg, 12 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to selenium nanocomposites of natural hepatotrophic galactose-containing polysaccharide matrixes, representing water-soluble orange-red powders containing zerovalent selenium (Se0) nanoparticles sized 1-100 nm in the quantitative content of 0.5 - 60 wt %, possessing antioxidant activity for treating and preventing redox-related pathologies, particularly for treating toxic liver damage, to a method for producing and to an antioxidant agent containing the above nanocomposites.

EFFECT: invention provides the targeted agent delivery to liver cells, as well as higher agent accessibility and lower toxic action of selenium.

7 cl, 11 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: method is implemented as follows: preparing a mixture 1 by adding 0.5M aqueous solution of selenious acid 250 mcl in PEG 400 8 ml, mixing thoroughly in a magnetic mixture at min. 750 rpm with pH of the given mixture 7.55; that is followed by preparing a mixture 2 by adding 0.5M aqueous solution of hydrazine hydrochloride 250 mcl in PEG 400 8 ml, mixing thoroughly in a magnetic mixture at min. 750 rpm with pH of the given mixture 0.68. The mixture 1 is added to the mixture 2 by mixing thoroughly drop by drop. The prepared solution is dialysed against distilled water with removing PEG 400 and hydrazine hydrochloride; the surplus water is distilled off in a rotary evaporator at 60 rpm and 70°C. The prepared solution is added with a low-molecular compound specified in a group of: gentamicin, hexamethylene tetramine, methionine, cephalexin, indole-3-carbinol; pH is reduced to 7.2-7.4. The components are mixed in an amount to provide their content in the agent, wt %: biologically active low-molecular compound 0.001-5.0; selenium 0.0001-1.0; water up to 100.

EFFECT: simplifying the technology.

2 tbl, 3 ex, 1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine and describes a method for producing glucosamine sulphate nanocapsules by non-solvent addition, wherein glucosamine sulphate is added in small amounts to a carrageenan suspension used as a nanocapsule shell in butanol, containing E472c preparation 0.01 g as a surfactant; the produced mixture is agitated and added with the non-solvent hexane 6 ml, filtered, washed in hexane and dried.

EFFECT: invention provides simplifying and accelerating the process of nanoencapsulation in carrageenan and higher weight yield.

2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of obtaining nanocomposite coatings and can be used in creation of optic microelectronic devices and materials with increased corrosion resistance and wear resistance. Method of obtaining two-phase nanocomposite coating, consisting of titanium carbide nanoclusters, distributed in amorphous hydrocarbon matrix, on products from hard alloys, includes application of adhesive titanium or chromium sublayer, magnetron sputtering of titanium target in gas mixture of acetylene and argon under pressure 0.01-1 Pa and precipitation of dispersed particles of target and carbon-containing radicals on product surface in combination with bombardment of surface with ions, accelerated by bias voltage, with product surface being subjected to purification with argon ions from plasma, generated by electronic beam, before application of adhesive sublayer, and gas mixture being activated in the process of coating application by impact with beam of electrons with energy 100 eV.

EFFECT: invention is aimed at increase of coating adhesion and micro-hardness of obtained products, as well as at provision of high efficiency of application of acetylene in the process of coating application.

1 ex, 2 dwg

FIELD: chemistry.

SUBSTANCE: catalyst contains carrier from porous zeolite KL and binding agent and catalytically active substance - platinum. Carrier additionally contains tin tetrachloride pentahydrate nanopowder, and as binding agent - mixture of gibbsite and rutile powders in equal proportions, with particle size of each not exceeding 40 mcm. Ratio of ingredients is in the following range, wt %: platinum - 0.3-0.8, mixture of gibbsite and rutile powders - 25-70, zeolite KL - 29.12-74.69, tin tetrachloride pentahydrate - 0.01-0.08. Claimed catalyst is characterised by high activity in reactions of aromatisation of synthetic hydrocarbons.

EFFECT: invention also relates to method of obtaining such catalyst.

2 cl, 1 tbl, 4 ex

FIELD: chemistry.

SUBSTANCE: invention relates to field of nanotechnology, in particular to plant growing, and deals with method of obtaining nanocapsules of 6-aminobenzylpurine. Method is characterised by the fact that 6-aminobenzylpurine is used as core and sodium alginate is used as envelope of nanocapsules, obtained by addition of E472c as surfactant to sodium alginate in butanol, portioned addition of 6-aminobenzylpurine into suspension of sodium alginate in butanol and further drop-by-drop introduction of precipitating agent-petroleum ether after formation of separate solid phase in suspension.

EFFECT: simplification and acceleration of process of obtaining nanoparticles and increased output by weight.

3 ex

FIELD: chemistry.

SUBSTANCE: method includes crushing and fractioning of initial material, delignification of initial raw material by alkaline hydration and alkaline pulping with further washings. After that, two-stage acidic hydrolysis with intermediate neutralisation and three washings is performed. Then, three-stage bleaching with hydrogen peroxide H2O2 with three washings is carried out. In second washing finely dispersed ozone is supplied. Obtained product is additionally subjected to homogenisation and drying. Invention makes it possible to obtain final product with virtually absolute absence of lignin, with high organoleptic and physical and chemical properties from lignin-containing initial material.

EFFECT: method does not require application of expensive equipment, does not involve application of highly toxic reagents, includes simple technological operations, is characterised by production scalability.

3 cl, 3 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention describes a method for producing Sel-Plex nanocapsules possessing the supramolecular properties by non-solvent addition, characterised by the fact that Sel-Plex is dissolved in dimethyl sulphoxide; the prepared mixture is dispersed in xanthum gum solution used as a nanocapsule shell, in butanol, in the presence of E472c preparation while stirring at 1000 cycles per second; the mixture is added with the precipitator benzol, filtered and dried at room temperature.

EFFECT: simplifying and accelerating the process of nanoencapsulation and ensuring higher weight yield.

4 ex, 12 dwg

FIELD: medicine.

SUBSTANCE: claimed invention relates to capsule for application with inhalator of dry powder, which contains composition in form of dry powder for pulmonary introduction, which contains mechanosynthesised microparticles, consisting of antibiotic and magnesium stearate.

EFFECT: invention relates to method of obtaining claimed capsule and its application in treatment of bacterial infection, associated with certain lungs diseases.

10 cl, 4 ex, 3 tbl, 1 dwg

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