Cache Banzimidazol-4-amide derivatives, methods for producing them, based pharmaceutical compositions and using them as coxsackie virus agent

Banzimidazol-4-amide derivatives, methods for producing them, based pharmaceutical compositions and using them as coxsackie virus agent

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to benzimidazole-4-carboxamide derivatives of formula , wherein X means an alkenyl group C2-C7 substituted by two methyls, nitro-radical mono-substituted thienyl, unsubstituted quinolinyl, unsubstituted indolyl, unsubstituted pyridazinyl, unsubstituted piperazinyl, C1-C6-alkyl disubstituted piperazinyl, unsubstituted piperidinyl, unsubstituted pyrazinyl, unsubstituted imidazolyl, unsubstituted pyrimidinyl, phenyl monosubstituted pyrimidinyl, pyrimidinyl disubstituted by an amine radical and a radical specified in a group containing -F, -Cl, -Br or -I, hydroxyl trisubstituted phenyl, methoxy-radical trisubstituted phenyl, hydroxyl and methoxy-radical disubstituted phenyl, pyrazolyl disubstituted by a radical specified in a group containing a C1-C6-alkyl, and by a radical specified in a group containing -F, -C1, -Br or -I; Y means aminophenyl monosubstituted by a radical of -F, -O, -Br or -I phenyl, hydroxyethyl disubstituted by hydroxymethyl or C1-C6-alkyl and phenyl monosubstituted by a nitro group, an amino group or a halogen atom; Y also means unsubstituted piperazinyl, unsubstituted pyridyl, unsubstituted pyrazinyl, C1-C6-alkyl monosubstituted thiazol, unsubstituted pyrimidinyl, unsubstituted purinyl. The invention also refers to a pharmaceutical composition based on the compound of formula (I), using the compound of formula (I), a method for producing the compound of formula (I).

EFFECT: there are prepared new benzimidazol-4-carboxamide derivatives possessing antiviral activity.

5 cl, 6 dwg, 4 tbl, 688 ex

 

The technical field TO WHICH the INVENTION RELATES

The present invention relates to a derivative of benzimidazole of carboxamide, in particular, to derive benzimidazol-4-carboxamide, methods for their preparation, pharmaceutical composition and their application.

BACKGROUND TO the INVENTION

Diseases caused by viral infections pose a serious threat to the health and life of humans and represent one of the most acute problems to be solved in the field of medicine. According to statistics almost 70% of epidemic diseases caused by viral infections. Often in many countries emerged infectious disease caused by enterovirus. Enteroviruses belong to the family of picornaviruses (picomaviridae), including polioviruses, Coxsackie virus, enteric orphan cytopathogenic human viruses (ECHO) and newer enteroviruses. Each type of virus has a large number of serotypes, at least more than 70 types that can cause the defeat of many types of tissues, such as nervous tissue, cardiac muscle, muscle tissue, skin, conjunctiva, etc., and can also lead to the emergence of many infectious diseases in different countries of the world. There are many types of Coxsackie virus, modes of transmission and pathogenesis of which are similar modes of transmission and pathogenesis of polio virus�, which often leads to the occurrence of latent infections. Symptoms of infection by these viruses manifest as infections of the upper respiratory tract of the weak form or in the form of diarrhea, and in some cases, these viruses infect the Central nervous system, affects the motor neurons of the anterior horns of the spinal cord and cause flaccid paralysis of the extremities, however, these symptoms are relatively mild. Coxsackie virus can affect various tissues and systems, such as respiratory tract, intestinal tract, the skin, muscle, heart, liver, adrenal glands and Central nervous system. Various clinical manifestations characteristic of different symptoms, such as: (1) infection of the respiratory tract, (2) gerpangina, (3) the fibril fever with a rash, (4) viral pemphigus of the mouth and extremities, (5) diarrhea in children (6) a disorder of the Central nervous system, (7) myocarditis and pericarditis, (8) an epidemic thoracalgia or epidemic myalgia, (9) epidemic conjunctivitis, (10) caused by Coxsackie virus hepatitis, etc.

SUMMARY the essence of the INVENTION

The objective of the present invention is to provide derivatives of benzimidazol-4-carboxamid, is able to counteract the Coxsackie virus, or their pharmaceutically acceptable salts, as shown in the formula (I).

in which X represents monosubstituted or disubstituted, or politeley C1-C14alkoxy, monosubstituted or disubstituted, or politeley C1-C14alkyl, monosubstituted or disubstituted, or politeley C2-C14of alkenyl, monosubstituted or disubstituted, or politeley C6-C14aryl, or monosubstituted or disubstituted, or polyamidine 5-6-membered heterocyclic group, or monosubstituted or disubstituted, or polyamidine group with articulated rings containing a heteroatom of nitrogen.

Y denotes hydrogen, monosubstituted, or disubstituted, or politeley1-C16alkyl, monosubstituted or disubstituted, or politeley C6-C12aryl, or monosubstituted or disubstituted, or polyamidine 5-6-membered heterocyclic group, or monosubstituted or disubstituted, or polyamidine group with articulated rings containing a heteroatom of nitrogen,

in which X is selected from one of the following groups:

,,,,,

,,,, ,

,,,,

,,,

,,,,

,or

in which R is selected from-H, orin which n is selected in the interval from 0 to 5, Rwy1, Rwy2, Rwy3, Rwy4and Rwy5respectively and independently selected from-H, -CH3or-CH2CH3;

n=0~5; R1, R2, R3, R4and R5respectively and independently selected from-H, -CH3, -F, -Cl, -Br, -I, -OH, -och3, -Och2CH3, -NO2, -NH-CH3, -NH-CH2CH3, -NH-CH2CH2OH,,,,,,or phenyl substituted by one or more substituents Ra, Ra is selected from-F, -Cl, -Br, -I, -CH3, -CH2CH3, -OH, -och3, -Och2CH3, -CH2CH2OH, -NO2, -NH2, -N(CH3)2, -N(CH2CH3)2, -N(CH2 CH2OH)2, -CN, -COOH, -COON3-SOON2CH3or-SOOS6N5;

R1', R2'and R3'are respectively and independently selected from-H, -CH3, -CH2CH3or

in which n is an integer in the range from 0 to 5; R1"and R2respectively and independently selected from-H, -CH3or-CH2CH3;

R9, R10, R11, R12and R13respectively and independently selected from-H, -CH3, -CH2CH3, -COOH , -COON3-SOON2CH3, -OH, -och3, -Och2CH3, -CN, -F, -Cl, -Br, -I, or-NH2, -N(CH3)2or-N(CH2CH3)2;

R17, R18, R19, R20, R'17, R'18, R'19, R'20, R"17, R"18, R"19and R20respectively and independently selected from-H, -CH3, -CH2CH3, -OH, -och3, -Och2CH3, -CF3, -CCl3, Is CBr3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -NO or-NO2that may not simultaneously denote H;

R23, R24, R25, R'23, R'24and R'25respectively and independently selected from-H, -CH3, -CH2CH3, -F, -Cl, -Br,-I, -OH, -och3, -Och2CH3, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -COOH, -COON3or-SOON2CH3;

R29, R30and R31respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

R34, R36and R41respectively and independently selected from-H, -(CH2)nCH3, -CH2OH, -CH2CH2OH, -CH(CH3)2or-CH2CH(Oh)CH3, n is an integer in the range from 0 to 5;

R35, R34, R38, R38, R40, R42and R43respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -R(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

Z is selected from N, O or S.

R44, R45, R46, R'44, R'45and R'46respectively and independently selected from-H, -CH3, -CH2CH3, -OH, -och3, -Och2CH3, -NO2, -NH 2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CN or-COOH, -COON3or-SOON2CH3;

Rs1, Rs2, R's1and R's2respectively and independently selected from-H, -CH3, -CH3CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -I, or NHCOCH3, NHCOCH2CH3or NHCOC6H5;

Rm1, Rm2, Rm3, R'm1, R'm2and R'm3respectively and independently selected from-H, -CH3, -CH2CH3, -F, -Cl, -Br, -I, -OH, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2,,,,or-NHC6H5;

Rk1, Rk2, Rk3, Rk4, Rk5and Rk6respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

RP1, RP2, RP3and P4respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

Ry1, Ry2, Ry3and Ry4respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

Rmz1 selected from-H, -CH3, -CH2CH3, -CH2CH2OH, -C6N5or-CH2With6N5; Rmz2 and Rmz3 respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

Rbz1 selected from-H, -CH3, -CH2CH3, -CH2CH2OH, -C6N5or-CH2With6N5; Rbz2 and Rbz3 respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH 2OH, or-N(CH2CH2OH)2;

Y is selected from one group of the following groups:

,,,,,

,,,,,,

,,,,

,,,,

,,,or

in which a, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R71, R72and R73respectively and independently selected from-H, -CH3, -CH2CH3, -CH2OH, -OH, -och3, -Och2CH3, -CN, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH) 2, -F, -Cl, -Br, -I, or-C6N5- 6N4-CH3- 6N4-OH, -C6H4-NO2or-C6H4-NH2;

R77, R78, R79, R80and R81respectively and independently selected from-H, -CH3, -CH2CH3, -OH, -och3,-Och2CH3, -NO2, -CN, -COOH, -COON3-SOON2CH3, -F, -Cl, -Br, -I, -CF3, -CCl3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2;

R85, R86and R87respectively and independently selected from-H, -CH3, -CH2CH3-HE or-NH2; R'85, R'86and R'87respectively and independently selected from-H, -CH3, -CH2CH3- 6N5or-CH2With6N4;

Q is selected from N, O or S;

R88, R89, R90, R'88', R'89and R'90respectively and independently selected from-H, -CH2CH3, -OH, -och3,-Och2CH3, -NO2, -NH2,-NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CN, -COOH, -COON3or-SOON2CH3;

R94, R95, R'94and R'95respectively and independently SEL�from Ana-N, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -I, or-NHCOCH3, NHCOCH2CH3or NHCOC6H5;

R96selected from-H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or-N(CH2CH2OH)2; R'96selected from-H, -CH3, -CH2CH3- 6N5or-CH2With6N4;

Rm1, Rm2, Rm3; R'm1, R'm2and R'm3respectively and independently selected from-H, -CH3, -CH2CH3, -F, -Cl, -Br, -I, -OH, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2or-NHC6H5;

Rb1, Rb2, Rb3and Rb4respectively and independently selected from-H, -CH3, -CH2CH3, -CH2OH, -OH, -och3, -OCH2CH3, -CN, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, or-I;

Rmz1selected from-H, -CH3, -CH2CH3, -CH2CH2OH, -C6N5or-CH 2With6N5; Rmz2 extensionand Rmz3respectively and independently selected from-H, -CH3, -CH2CH3, -Och3, -CH2OH, -NO2or-NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CONH2or-COOH;

Rp11and Rp12respectively and independently selected from-H, -CH3, -CH2CH3, - OH, -och3, -Och2CH3, F, Cl, Br, or I; Rp13selected from-H, -CH3, -CH2CH3, -CH2CH2OH, -C6N5or-CH2With6N5.

X preferably represents monosubstituted or politeley or unsubstituted alkoxy, monosubstituted or politeley or unsubstituted alkyl, monosubstituted or politeley or unsubstituted of alkenyl, monosubstituted or disubstituted or unsubstituted thienyl, monosubstituted, or disubstituted or unsubstituted pyridyl, monosubstituted, or disubstituted or unsubstituted pyridazinyl, monosubstituted, or disubstituted or unsubstituted piperazinyl, monosubstituted, or disubstituted or unsubstituted pyrazinyl, monosubstituted, or disubstituted or unsubstituted thiazolyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted phenyl, monosubstituted, �for disubstituted, or an unsubstituted pyrimidinyl, monosubstituted, or disubstituted or unsubstituted pyrrolyl, monosubstituted, or disubstituted or unsubstituted chinoline, monosubstituted, or disubstituted or unsubstituted piperidinyl, monosubstituted, or disubstituted or unsubstituted indole, monosubstituted, or disubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted pyrazolyl.

More preferably, X stands for C1-C6, alkyloxy, substituted nitro, amino, hydroxyl or aryl; C1-C6 alkyl, substituted nitro, amino, hydroxyl or aryl; C2-C14 alkenyl of substituted by alkyl, hydroxyl or aryl; thienyl, monosubstituted nitro, amino or C1-C6 by alkyl; an unsubstituted thienyl; pyridyl (pyidyl), monosubstituted nitro, amino or C1-C6, the alkyl; unsubstituted pyridyl;

chinoline, monosubstituted nitro, amino or C1-C6 by alkyl; an unsubstituted chinoline; indole, mono-substituted nitro, amino or C1-C6, the alkyl; unsubstituted indole; pyridyl, monosubstituted or disubstituted C1-C6 alkoxy; pyridyl, monosubstituted or disubstituted C1-C3, dialkylamino; pyridyl, monosubstituted or disubstituted C1-C6, the alkyl; unsubstituted pyridyl; pyridazinyl, monosubstituted C1-C6 alkoxy; pyridazinyl, monosubstituted C1-C6 by alkyl; an unsubstituted pyridazinyl; nezam�sacred piperazinyl; piperazinyl, disubstituted C1-C6 by alkyl; an unsubstituted piperidinyl; an unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl, monosubstituted nitro, amino or C1-C6, the alkyl; unsubstituted imidazolyl; thiazolyl, disubstituted C1-C6, the alkyl and nitro; an unsubstituted pyrimidinyl; pyrimidinyl, monosubstituted by phenyl; pyrimidinyl, disubstituted amino, and a group selected from nitro, -F, -Cl, -Br or-I; phenyl, trisubstituted by trihydroxide; phenyl, trisubstituted by timetokill; phenyl, disubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from bromide, ethyl, carboxyl or amido; pyrazolyl, disubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl, and a group selected from-F, -Cl, -Br or-I.

Y preferably represents hydroxyl, C1-C6 alkyl, monosubstituted, or disubstituted or trisubstituted phenyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted, or disubstituted or unsubstituted pyrazinyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted ties�Lil, monosubstituted or disubstituted or trisubstituted or unsubstituted benzenemethanol, monosubstituted, or disubstituted, or trisubstituted, either tetrasomy or unsubstituted benzimidazolyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted of benzimidazolinyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted purines.

More preferably Y represents gidroximetil, hydroxyethyl, Dapsone base, hydroxyphenyl, C1-C6 alkylphenyl, phenyl, monosubstituted,- F, -C1, -Sh, or-I, phenyl, disubstituted by hydroxyl and carboxyl, hydroxyethyl, disubstituted by gidroximetil or C1-C6, the alkyl and monosubstituted with phenyl, piperazinyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted C1-C6, the alkyl, pyridyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted C1-C6, the alkyl, pyrazinyl, monosubstituted, or disubstituted or unsubstituted C1-C6, the alkyl, piperazinyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted C1-C6, the alkyl, pyrrolyl, monosubstituted, or disubstituted or trisubstituted or unsubstituted C1-C6, the alkyl, thiazolyl, monosubstituted C1-C6, the alkyl, pyrimidinyl, monosubstituted, or disubstituted, lib� unsubstituted C1-C6, the alkyl, pyrimidinyl, monosubstituted C1-C6, the alkyl and disubstituted by hydroxyl, pyrimidinyl, monosubstituted C1-C6, the alkyl and disubstituted or trisubstituted,- F, -Cl, -Br or-I, purinol, monosubstituted, or disubstituted or unsubstituted C1-C6, the alkyl, purinol, monosubstituted C1-C6, the alkyl (alky) and disubstituted or trisubstituted by hydroxyl.

Most preferably, the derivative benzimidazol-4-carboxamid, as shown in equation (1), included the following connections:

(1)(L)-2-(5-nitro-2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(2)(L)-2-(5-amino-2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(3)(L)-2-(5-amino-2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(4)2-(5-amino-2-thienyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(5)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(6)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-o-chlorophenyl)amide

(7)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-bromophenyl)amide

(8)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(9)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-m-chlorophenyl)amide

(10)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-m-bromophenyl)amide

(11)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(12)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-p-chlorophenyl)amide

(13)2-(5-amino-2-year - �Neal)-1H-benzimidazol-4-(N-p-bromophenyl)amide

(14)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-o-methylphenyl)amide

(15)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(16)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(17)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-m-methylphenyl)amide

(18)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(19)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(20)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-p-methylphenyl)amide

(21)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(22)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(23)(L)-2-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(24)(L)-2-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(25)2-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(26)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(27)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-chlorophenyl)amide

(28)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-bromophenyl)amide

(29)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(30)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(31)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(32)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(33)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-m-guide�of oxyphenyl)amide

(34)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(35)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(36)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(37)(L)-2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(38)(L)-2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(39)2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(40)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(41)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(42)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(43)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(44)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(45)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(46)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(47)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(48)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(49)(L)-2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(50)(L)-2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(51 )2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl, hydroc�ITIL)]amide

(52)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(53)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(54)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(55)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(56)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(57)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(58)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(59)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(60)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(61)(L)-2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(62)(L)-2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(63)2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(64)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(65)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(66)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(67)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(68)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(69)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(70)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(71)2-(3-pyridazin�yl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(72)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(73)(L)-2-(2-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(74)(L)-2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(75)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(76)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-[N-Oh-fluorophenyl)amide

(77)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-[N-m-fluorophenyl)amide

(78)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(79)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(80)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(81)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(82)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(83)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(84)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(85)(L)-2-(2-pyrazinyl)-1H-benzimidazol-4-[H-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(86)(L)-2-(2-pyrazinyl)-1H-benzimidazol-4-[H-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(87)2-(2-pyrazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(88)2-(2-pirate�yl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(89)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(90)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(91)2-(2-pyrazinyl)-1H-benzimidazol-4-^-o-hydroxyphenyl)amide

(92)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(93)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(94)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(95)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(96)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(97)(L)-2-piperazinyl-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(98)(L)-2-N-piperazinyl-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(99)2-N-piperazinyl-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(100)2-N-piperazinyl-1H-benzimidazol-4-(N-o-fluorophenyl)amide (101 )2-piperazinyl-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(102)2-N-piperazinyl-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(103)2-N-piperazinyl-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(104)2-N-piperazinyl-1H-benzimidazol-4-(N-o-Dapsone base)amide

(105)2-N-piperazinyl-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(106)2-N-piperazinyl-1H-benzimidazol-4-(N-m-Dapsone base)amide

(107)2-N-piperazinyl-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(108)2-N-piperazinyl-1H-benzimidazol-4-(N-p-Dapsone base)amide

(109)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-hydroxy�ethyl-2-p-nitro phenyl hydroxyethyl)]amide

(110)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-amino phenyl hydroxyethyl)]amide

(111)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(112)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(113)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(114)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(115)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(116)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(117)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(118)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(119)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(120)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(121 )(L)-2-thiazolyl-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(122)(L)-2-thiazolyl-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(123)2-thiazolyl-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(124)2-thiazolyl-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(125)2-thiazolyl-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(126)2-thiazolyl-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(127)2-thiazolyl-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(128)2-thiazolyl-1H-benim�Gasol-4-(N-o-Dapsone base)amide

(129)2-thiazolyl-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(130)2-thiazolyl-1H-benzimidazol-4-(N-m-Dapsone base)amide

(131)2-thiazolyl-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(132)2-thiazolyl-1H-benzimidazol-4-(N-p-Dapsone base)amide

(133)(L)-5-thiazolyl-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(134)(L)-5-thiazolyl-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(135)5-thiazolyl-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(136)5-thiazolyl-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(137)5-thiazolyl-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(138)5-thiazolyl-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(139)5-thiazolyl-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(140)5-thiazolyl-1H-benzimidazol-4-(N-o-Dapsone base)amide

(141)5-thiazolyl-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(142)5-thiazolyl-1H-benzimidazol-4-(N-m-Dapsone base)amide

(143)5-thiazolyl-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(144)5-thiazolyl-1H-benzimidazol-4-(N-p-Dapsone base)amide

(145)(L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-R-nitro Anil hydroxyethyl)]amide

(146)(L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-amino Anil hydroxyethyl)]amide

(147)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(148)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-o-fluoro�enyl)amide

(149)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(150)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(151)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(152)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(153)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(154)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(155)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(156)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(157)(L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(158)(L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(159)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(160)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-[N-Oh-fluorophenyl)amide

(161)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(162)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(163)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(164)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(165)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(166)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(17)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(168)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(169)(L)-2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(170)(L)-2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(171)2-(2-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(172)2-(2-pyrimidinyl)-1H-benzimidazol-4-[N-Oh-fluorophenyl)amide

(173)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(174)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(175)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(176)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(177)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(178)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(179)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(180)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(181)(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(182)(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-amino phenyl hydroxyethyl)]amide

(183)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(184)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(185)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(186)2-(2-phenyl--pyrimidinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(187)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(188)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(189)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(190)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide (191 )2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(192)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(193)(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(194)(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(195)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(196)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(197)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(198)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(199)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(200)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(201)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(202)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(203)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(204)2-(4-Amin�-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-p-Dapsone base)amide

(205)(L)-2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(206)(L)-2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(207)2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(208)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(209)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(210)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(211)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(212)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(213)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(214)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(215)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(216)(L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(217)(L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-[M-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(218)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(219)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(220)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(221)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(222)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(223)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(225)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(226)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(227)(L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(228)(L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(229)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(230)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(231)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(232)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(233)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(234)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(235)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(236)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(237)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(238)(L)-2-(2-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(239)(L)-2-(2-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(240)2-(2-chinoline)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(241)2-(2-chinoline)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(242)2-(2-chinoline)-1H-benzimidazol-4-(m-fluorophenyl)amide

(243)2-(2-chinoline)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(244)2-(2-chinoline)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(245)2-(2-chinoline)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(246)2-(2-chinoline)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(247)2-(2-chinoline)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(248)2-(2-chinoline)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(249)(L)-2-(3-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(250)(L)-2-(3-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(251)2-(3-chinoline)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(252)2-(3-chinoline)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(253)2-(3-chinoline)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(254)2-(3-chinoline)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(255)2-(3-chinoline)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(256)2-(3-chinoline)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(257)2-(3-chinoline)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(258)2-(3-chinoline)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(259)2-(3-chinoline)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(260)(L)-2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(261 )(L)-2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(262)2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-methyl�-2-p-chlorophenyl hydroxyethyl)]amide

(263)2-(2-piperidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(264)2-(2-piperidinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(265)2-(2-piperidinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(266)2-(2-piperidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(267)2-(2-piperidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(268)2-(2-piperidinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(269)2-(2-piperidinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(270)2-(2-piperidinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(271)(L)-2-(3-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(272)(L)-2-(3-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(273)2-(3-piperidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(274)2-(3-piperidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(275)2-(3-piperidinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(276)2-(3-piperidinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(277)2-(3-piperidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(278)2-(3-piperidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(279)2-(3-piperidinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(280)2-(3-piperidinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(281)2-(3-piperidinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(282)(L)-2-(4-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydrox�ethyl)]amide ,

(283)(L)-2-(4-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(284)2-(4-piperidinyl)-1H-benzimidazol-4-[N-(methyl-2-p-chlorophenyl hydroxyethyl)]amide

(285)2-(4-piperidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(286)2-(4-piperidinyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(287)2-(4-piperidinyl)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(288)2-(4-piperidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(289)2-(4-piperidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(290)2-(4-piperidinyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(291)2-(4-piperidinyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(292)2-(4-piperidinyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(293)(L)-2-(3-indole)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(294)(L)-2-(3-indole)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(295)2-(3-indole)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(296)2-(3-indole)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(297)2-(3-indole)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(298)2-(3-indole)-1H-benzimidazol-4-(N-p-fluorophenyl)amide

(299)2-(3-indole)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(300)2-(3-indole)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(301)2-(3-indole)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(302)2-(3-indole)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(303)2-(3-Indo�yl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(304)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(305)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(306)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(307)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(308)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-m-fluorophenyl)amide

(309)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-(1-p-fluorophenyl)amide

(310)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(311)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(312)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(313)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(314)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(315)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(316)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(317)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)] amide

(318)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

(319)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-m-fluorophenyl)amide

(320)2-(3-hydroxyl-4-methoxyphenyl)-1H-Ben�imidazole-4-(N-p-fluorophenyl)amide

(321)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(322)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-o-Dapsone base)amide

(323)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-m-hydroxyphenyl)amide

(324)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-m-Dapsone base)amide

(325)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-p-hydroxyphenyl)amide

(326)(L)-2-methoxy-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(327)(L)-2-methoxy-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)] amide

(328)2-methoxy-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(329)2-methoxy-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(330)2-methoxy-1H-benzimidazol-4-(N-2-piperazinyl)amide

(331)2-methoxy-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(332)2-methoxy-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(333)2-methoxy-1H-benzimidazol-4-(N-o-Dapsone base)amide

(334)2-methoxy-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(335)2-methoxy-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(336)2-methoxy-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(337)2-methoxy-1H-benzimidazol-4-(N-2-imidazolyl)amide

(338)2-methoxy-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(339)2-methoxy-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(340)2-methoxy-1H-benzimidazol-4-(N'-ethyl-1-piperazinyl)amide

(341)2-me�hydroxy-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(342)2-methoxy-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(343)2-methoxy-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(344)2-methoxy-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(345)2-methoxy-1H-benzimidazol-4-(N-2-pyridyl)amide

(346)2-methoxy-1H-benzimidazol-4-(N-3-pyridyl)amide

(347)2-methoxy-1H-benzimidazol-4-(N-4-pyridyl)amide

(348)2-methoxy-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(349)2-methoxy-1H-benzimidazol-4-(N-5-thiazolyl)amide

(350)2-methoxy-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(351)2-methoxy-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(352)2-methoxy-1H-benzimidazol-4-(N-4-chloro-b-amino-2-pyrimidinyl)amide

(353)2-methoxy-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(354)(L)-2-ethoxy-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(355)(L)-2-ethoxy-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(356)2-ethoxy-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(357)2-ethoxy-1H-benzimidazol-4-(N-piperidinyl)amide

(358)2-ethoxy-1H-benzimidazol-4-(N-2-piperazinyl)amide

(359)2-ethoxy-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(360)2-ethoxy-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(361)2-ethoxy-1H-benzimidazol-4-(N-o-Dapsone base)amide

(362)2-ethoxy-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(363)2-ethoxy-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)and�ID

(364)2-ethoxy-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(365)2-ethoxy-1H-benzimidazol-4-(N-2-imidazolyl)amide

(366)2-ethoxy-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(367)2-ethoxy-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(368)2-ethoxy-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(369)2-ethoxy-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(370)2-ethoxy-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(371)2-ethoxy-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(372)2-ethoxy-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(373)2-ethoxy-1H-benzimidazol-4-(N-2-pyridyl)amide

(374)2-ethoxy-1H-benzimidazol-4-(N-3-pyridyl)amide

(375)2-ethoxy-1H-benzimidazol-4-(N-4-pyridyl)amide

(376)2-ethoxy-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(377)2-ethoxy-1H-benzimidazol-4-(N-5-thiazolyl)amide

(378)2-ethoxy-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(379)2-ethoxy-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(380)2-ethoxy-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(381)2-ethoxy-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(382)(L)-2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(383)(L)-2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-gidroximetil-2-R-AMI nofeel hydroxyethyl)]amide

(384)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(385)2-(2,6-dimethy�-2,6-octadienal)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(386)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(387)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(388)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(389)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(390)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(391)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(392)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(393)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(394)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(395)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(-(N'-piperazinyl))amide

(396)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-ethyl-N-piperazinyl)amide

(397)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(398)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(399)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(400)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(401)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyridyl)amide

(402)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-3-pyridyl)amide

(403)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-pyridyl)amide

(404)2-(2,6-dimethyl-2B-octadienal)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(405)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(406)2-(2,6-dimethyl-2,6-Ogadeni)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(407)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(408)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidine yl)amide

(409)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(410)(L)-2-pyrazolin-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(411 )(L)-2-pyrazolin-1H-benzimidazol-4-[N-(1-Hydra;imethyl-2-p-Dapsone base hydroxyethyl)]amide

(412)2-pyrazolyl-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(413)2-pyrazolyl-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(414)2-pyrazolyl-1H-benzimidazol-4-(N-2-piperazinyl)amide

(415)2-pyrazolyl-1H-benzimidazol-4-(N-N'-benzimidazolyl)amide

(416)2-pyrazolyl-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(417)2-pyrazolyl-1H-benzimidazol-4-(N-o-Dapsone base)amide

(418)2-pyrazolyl-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(419)2-pyrazolyl-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(420)2-pyrazolyl-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(421)2-pyrazolyl-1H-benzimidazol-4-(N-2-imidazolyl)amide

(422)2-pyrazolyl-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(423)2-pyrazolyl-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(424)2-p�Rasool-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(425)2-pyrazolyl-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(426)2-pyrazolyl-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(427)2-pyrazolyl-1H-benzimidazol-4-(N-4-4-pyrimidinyl)amide

(428)2-pyrazolyl-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(429)2-pyrazolyl-1H-benzimidazol-4-(S-2-pyridyl)amide

(430)2-pyrazolyl-1H-benzimidazol-4-(N-3-pyridyl)amide

(431)2-pyrazolyl-1H-benzimidazol-4-(N-4-pyridyl)amide

(432)2-pyrazolyl-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(433)2-pyrazolyl-1H-benzimidazol-4-(N-5-thiazolyl)amide

(434)2-pyrazolyl-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(435)2-pyrazolyl-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(436)2-pyrazolyl-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(437)2-pyrazolyl-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(438)(L)-2-(2'-pyridyl)-1H-benzimidazol-4-[-N(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(439)(L)-2-(2'-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)] amide

(440)2-(2'-pyridyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(441)2-(2'-pyridyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(442)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(443)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(444)2-(2'-pyridyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(445)2-(2'-pyridyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(4462-(2'-pyridyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(447)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(448)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(449)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(450)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(451)2-(2'-pyridyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(452)2-(2'-pyridyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(453)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(454)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(455)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(456)2-(2'-pyridyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(457)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(458)2-(2'-pyridyl)- 1H-benzimidazol-4-(N-3-pyridyl)amide

(459)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(460)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(461)2-(2'-pyridyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(462)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(463)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(464)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(465)2-(2'-pyridyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(466)(L)-2(3'-pyridyl)-1H-benzimidazol-4-[N-(1-hydroxymethyl-2-R-nitrophenyl hydroxyethyl)]amide

(467)(L)-2-(3'-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(468)2-(3'-pyridyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(469)2-(3'-pyridyl)-1H-benzimidazol-4-(N-(1-piperidinyl)amide

(470)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(471)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(472)2-(3'-pyridyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(473)2-(3'-pyridyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(474)2-(3'-pyridyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(475)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(476)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(477)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(478)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(479)2-(3'-pyridyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(480)2-(3'-pyridyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(481)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(482)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(483)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(484)2-(3'-pyridyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(485)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(486)2-(3'-pyridyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(487)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(488)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(489)2-(3'-pyridyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(490)2-(3'-pyridyl)-1H-Benzi�idazole-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(491)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(492)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(493)2-(3'-pyridyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(494)(L)-2-(4'-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(495)(L)-2-(4'-pyridyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(496)2-(4'-pyridyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(497)2-(4'-pyridyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(498)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(499)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(500)2-(4'-pyridyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(501)2-(4'-pyridyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(502)2-(4'-pyridyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(503)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(504)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(505)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(506)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(507)2-(4'-pyridyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(508)2-(4'-pyridyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(509)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(510)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(511)2-(4'-pyridyl)-1H-Benzi�idazole-4-(N-4-pyrimidinyl)amide

(512)2-(4'-pyridyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(513)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(514)2-(4'-pyridyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(515)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(516)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(517)2-(4'-pyridyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(518)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(519)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(520)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(521)2-(4'-pyridyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(522)(L)-2-(2'-imidazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(523)(L)-2-(2'-imidazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(524)2-(2'-imidazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

(525)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(526)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(527)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(528)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(529)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(530)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(531)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

532)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(533)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(534)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(535)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(536)2-(2'-imidazolyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(537)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(538)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(539)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(540)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(541)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(542)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(543)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(544)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(545)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(546)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(547)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(548)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(549)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(550)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(551)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(552)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(553)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)AMI�

(554)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(555)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(556)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(557)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(558)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(559)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(560)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(561)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(562)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(563)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(564)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(565)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(566)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(567)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(568)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(569)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(570)2-(4-methoxytrityl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(571)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(572)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(573)2-(6-methoxyphenyl)-1H-benzimidazol-4-(NN'-piperidinyl)amide

(574)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(575)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(576)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(577)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(578)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(579)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(580)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(581)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(582)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(583)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(584)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(585)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(586)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(587)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(588)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(589)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(590)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(591)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(592)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(593)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidiny�)amide

(594)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(595)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(596)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(597)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(598)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(599)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(600)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(601)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(602)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(603)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(604)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(605)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(606)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(607)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(608)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(609)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(610)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(611 )2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(612)2-(4-dimethylaminophenyl)-1�-benzimidazol-4-(N-4-pyridyl)amide

(613)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(614)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(615)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(616)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(617)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(618)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(619)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(620)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(621)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(622)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(623)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(624)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(625)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(626)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(627)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(628)2-(3-pyridazinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(629)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(630)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(631)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(632)2-(3-pyridazinyl)-1H-benzo�midazol-4-(N-5-pyrimidinyl)amide

(633)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(634)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(635)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(636)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(637)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(638)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(639)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(640)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(641)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(642)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-(N'-piperidinyl)amide

(643)2-(2-N-methyl-4-methylpiperazine)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(644)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(645)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(646)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(647)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(648)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(649)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(650)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(651)2-(2-N-methyl-4-N-Meile�eratini)-1H-benzimidazol-4-(N-ethyl-N-piperazinyl)amide

(652)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(653)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(654)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(655)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(656)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2-pyridyl)amide

(657)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-3-pyridyl)amide

(658)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4-pyridyl)amide

(659)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(660)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(661)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrim idini)amide

(662)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimid inyl)amide

(663)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide

(664)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(665)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(666)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(667)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(668)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(669)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imide�of ail)amide

(670)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(671)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(672)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(673)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(674)2-(2-pyrazinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(675)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(676)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(677)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(678)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(679)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(680)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(681)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(682)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(683)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(684)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(685)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(686)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(687)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(688)2-(2-piperazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(689)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(690)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(691)2-(2-piperazinyl)-1H-benzimida�Zol-4-(N-5-benzimidazolinyl)amide

(692)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(693)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(694)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(695)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(696)2-(2-piperazinyl)-1H-benzimidazol-4-(N-N'-piperazinyl))amide

(697)2-(2-piperazinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(698)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(699)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(700)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(701)2-(2-piperazinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(702)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(703)2-(2-piperazinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(704)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(705)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(706)2-(2-piperazinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(707)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(708)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(709)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(710)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(711)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(712)2-(4-methyl-5-aminothiazolyl)-1H-be�imidazol-4-(N-2-piperazinyl))amide

(713)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(714)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(715)2-(4-methyl-5-aminothiazolyl)-1H-beomeosa-4-(N-4'-carbonamide-5'-imidazolyl)amide

(716)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(717)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(718)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(719)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(720)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-ethyl-piperazinyl)amide

(721)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(722)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(723)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(724)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(725)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(726)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(727)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(728)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(729)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(730)2-(4-methyl-5-aminc)thiazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(731)2-(4-methyl-5-aminothio�of ail)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(732)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(733)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(734)2-(2-thiazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(735)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(736)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(737)2-(2-thiazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(738)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(739)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(740)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(741)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(742)2-(2-thiazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(743)2-(2-thiazolyl)-1H-benzimidazol-4-(N'-ethyl-piperazinyl)amide

(744)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(745)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(746)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(747)2-(2-thiazolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(748)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(749)2-(2-thiazolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(750)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(751)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(752)2-(2-thiazolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(753)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2,4-dihydro�force-5-pyrimidinyl)amide

(754)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(755)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(756)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(757)2-(5-thiazolyl)-1H-benzimidazol-4-(N-(N'-piperidinyl)amide

(758)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(759)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(760)2-(5-thiazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(761)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(762)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(763)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(764)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(765)2-(5-thiazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(766)2-(5-thiazolyl)-1H-benzimidazol-4-(N-ethyl-N-piperazinyl)amide

(767)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(768)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(769)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(770)2-(5-thiazolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(771)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(772)2-(5-thiazolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(773)2-(2-thiazolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(774)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(775)2-(5-thiazolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

<> (776)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(777)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(778)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(779)2-(5-thiazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(780)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(781)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(782)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(783)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(784)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(785)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(786)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(787)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(788)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(789)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(790)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(791)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(792)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(793)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(794)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(795)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(796)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrid�l)amide

(797)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(798)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(799)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(800)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(801)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(802)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(803)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(804)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(805)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(806)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(807)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(808)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(809)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(810)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(811)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N-piperazinyl))amide

(812)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(813)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(814)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(815)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrimid�Neal)amide

(816)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(817)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(818)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(819)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(820)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(821)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(822)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(823)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(824)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(825)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(826)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(827)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(828)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(829)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(830)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(831)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(832)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(833)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-�irazola)amide

(834)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(835)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N'-ethyl)-piperazinyl)amide

(836)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(837)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-2-pyrimidinyl)amide

(838)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(839)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(840)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(841)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(842)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(843)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(844)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(845)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(846)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(847)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(848)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(849)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(850)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(851)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)and�ID

(852)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(853)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(854)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(855)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(856)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(857)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(858)2-(2-pyrrolyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(859)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(860)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(861)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(862)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(863)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(864)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(865)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(866)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(867)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(868)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(869)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(870)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(871)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(872)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-N' -piperidinyl)amide

(873)2-(N-methyl-2-pyrrolyl)-1H-benzimidazo�-4-(N-2-piperazinyl))amide

(874)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(875)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(876)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(877)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(878)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(879)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(880)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(881)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(882)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(883)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(884)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(885)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(886)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(887)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(888)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(889)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(890)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(891)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(892)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(893)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-�ENT-6-amino-2-pyrimidinyl)amide

(894)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(895)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(896)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(897)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(898)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(899)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(900)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(901)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(902)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(903)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(904)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(905)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(906)of 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(907)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(908)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(909)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(910)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(911)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(912)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(913)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(914)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(915)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(916)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(917)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(918)2-(2-chinoline)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(919)2-(2-chinoline)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(920)2-(2-chinoline)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(921)2-(2-chinoline)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(922)2-(2-chinoline)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(923)2-(2-chinoline)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(924)2-(2-chinoline)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(925)2-(2-chinoline)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(926)2-(2-chinoline)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(927)2-(2-chinoline)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(928)2-(2-chinoline)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(929)2-(2-chinoline)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(930)2-(2-chinoline)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(931)2-(2-chinoline)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(932)2-(2-chinoline)-1H-benzimidazol-4-(N-2-pyridyl)amide

(933)2-(2-chinoline)-1H-benzoni�Azol-4-(N-3-pyridyl)amide

(934)2-(2-chinoline)-1H-benzimidazol-4-(N-4-pyridyl)amide

(935)2-(2-chinoline)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(936)2-(2-chinoline)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(937)2-(2-chinoline)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(938)2-(2-chinoline)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(939)2-(2-chinoline)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(940)2-(2-chinoline)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(941)2-(2-piperidinyl)-1H-benzimidazol-4-(N'-piperidinyl)amide

(942)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(943)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(944)2-(2-piperidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(945)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(946)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(947)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(948)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(949)2-(2-piperidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(950)2-(2-piperidinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(951)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(952)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(953)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(954)2-(2-piperidinyl)-1H-benzimidazol-4-(N-5-p�rimidine)amide

(955)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(956)2-(2-piperidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(957)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(958)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(959)2-(2-piperidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(960)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(961)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(962)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(963)2-(2-piperidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(964)2-(3-piperidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(965)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(966)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(967)2-(3-piperidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(968)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(969)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(970)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(971)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(972)2-(3-piperidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(973)2-(3-piperidinyl)-1H-benzimidazol-4-(N-ethyl-N-piperazinyl)amide

(974)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(975)2-(3-piperidinyl)-1H-benzimidazo�l-4-(N-2-pyrimidinyl)amide

(976)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(977)2-(3-piperidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(978)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(979)2-(3-piperidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(980)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(981)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(982)2-(3-piperidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(983)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(984)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(985)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(986)2-(3-piperidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(987)2-(4-piperidinyl)-1H-benzimidazol-4-(N'-piperidinyl)amide

(988)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(989)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(990)2-(4-piperidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(991)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(992)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(993)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(994)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(995)2-(4-piperidinyl)-1H-benzimidazol-4-(N-N'-piperazinyl))amide

(996)2-(4-piperidinyl)-1H-benzimidazol-4-(N-ethyl-N-piperazinyl)amide

(997)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(998)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(999)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1000)2-(4-piperidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1001)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1002)2-(4-piperidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1003)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1004)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1005)2-(4-piperidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1006)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1007)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(1008)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1009)2-(4-piperidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1010)2-(3-indole)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1011)2-(3-indole)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(1012)2-(3-indole)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1013)2-(3-indole)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1014)2-(3-indole)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1015)2-(3-indole)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1016)2-(3-indole)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1017)2-(3-indole)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1018)2(3-indole)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1019)2-(3-indole)-1H-benzimidazol-4-(N-ethyl-N'-piperazinyl)amide

(1020)2-(3-indole)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1021)2-(3-indole)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1022)2-(3-indole)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1023)2-(3-indole)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1024)2-(3-indole)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1025)2-(3-indole)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1026)2-(3-indole)-1H-benzimidazol-4-(N-pyridyl)amide

(1027)2-(3-indole)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1028)2-(3-indole)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1029)2-(3-indole)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1030)2-(3-indole)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(1031)2-(3-indole)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1032)2-(3-indole)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1033)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1034)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(1035)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1036)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1037)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1038)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1039)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-N-2-imidazolyl)amide

(1040)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1041)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1042)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1043)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1044)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1045)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1046)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1047)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1048)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1049)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1050)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1051)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1052)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1053)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(1054)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1055)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1056)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1057)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(1058)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazo�l-4-^-2'-benzimidazolyl)amide

(1059)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1060)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1061)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1062)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1063)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1064)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1065)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1066)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1067)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1068)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1069)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1070)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1071)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1072)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1073)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1074)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1075)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1076)2-(3-hydroxyl-4-netoxygen�l)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(1077)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1078)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1079)(L)-2-(2-bromo-5-pyridine)-1H-benzimidazol-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide

(1080)(L)-2-(2-bromo-5-pyridine)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(1081)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(1082)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-[N-(N'-piperidinyl)amide

(1083)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(1084)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1085)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(1086)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(1087)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1088)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1089)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1090)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1091)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1092)2-(2-bromo-5-pyridine)-lH-benzimidazol-4-(N-(N'-piperazinyl))amide

(1093)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1094)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N'-2-pyrazinyl)amide

(1095)2-(2-bromo-5-PIR�Dean)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1096)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1097)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1098)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1099)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1100)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1101)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1102)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1103)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1104)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4,6-di(2-bromo-5-pyridin)-2-pyrimidinyl)amide

(1105)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1106)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1107)(L)-2-(2-amino-3-pyridine)-1H-benzimidazol-4-RM-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(1108)(L)-2-(2-amino-3-pyridine)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(1109)2-(2-amino-3-pyridine)-1H-benzimidazol-4-RM-(1-MESL-2-p-chlorophenyl of hidroxil)]amide

(1110)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-piperidinyl)amide

(1111)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2-piperazinyl))amide

(1112)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1113)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(1114)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-�-Dapsone base)amide

(1115)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1116)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1117)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1118)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1119)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1120)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-(N-piperazinyl))amide

(1121)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1122)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1123)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1124)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1125)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1126)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1127)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1128)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1129)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1130)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1131)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1132)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimidinyl)amide

(1133)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1134)2-(2-amino-3-pyridine)-1H-benzimidazo�l-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1135)(L)-2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(1136)(L)-2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(1137)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl

hydroxyethyl)]amide

(1138)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1139)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(1140)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1141)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(1142)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(1143)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1144)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1145)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1146)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1147)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1148)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1149)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-ethyl-N'-piperazinyl)amide

(1150)2-(2-pyrrolidin-1-�l-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1151)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1152)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1153)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1154)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1155)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1156)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyridyl)amide

(1157)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1158)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-thiazolyl)amide

(1159)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-Piri Meinel)amide

(1160)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-di(2-pyrrolidin-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide

(1161)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1162)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1163)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(1164)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(1165)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(N-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(1166)2-(2-p�of peridin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1167)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(1168)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1169)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(1170)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(1171)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1172)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1173)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazole)amide

(1174)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1175)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1176)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1177)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1178)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1179)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1180)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1181)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1182)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1183)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-3-Piri�yl)amide

(1184)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1185)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1186)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(5-thiazolyl)amide

(1187)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1188)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-di(2-piperidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide

(1189)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1190)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1191)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(1192)(b)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(1193)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(1194)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1195)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(1196)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1197)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(1198)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-�-Dapsone base)amide

(1199)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1200)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide;

(1201)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazolyl)amide

(1202)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-imidazolyl)amide

(1203)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1204)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1205)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1206)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1207)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1208)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1209)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1210)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1211)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1212)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1213)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1214)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(5-thiazolyl)amide

(1215)2-(2-Cyclops�operamini-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1216)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-di(2-cyclopropylamino-5-pyrimidinyl)-2-pyrimidinyl)amide

(1217)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-PIR imaginal)amide

(1218)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide.

(1219)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

(1220)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

(1221)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

(1222)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

(1223)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

(1224)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

(1225)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-hydroxyphenyl)amide

(1226)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

(1227)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

(1228)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

(1229)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4'-carboxyl-5'-imidazole l)amide

(1230)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-imide�of ail)amide

(1231)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

(1232)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

(1233)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N'-ethyl-N-piperazinyl)amide

(1234)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

(1235)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

(1236)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4-pyrimidinyl)amide

(1237)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-5-pyrimidinyl)amide

(1238)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

(1239)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-3-pyridyl)amide

(1240)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

(1241)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

(1242)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(5-thiazolyl)amide

(1243)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

(1244)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(1245)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

(1246)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

(1247)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1248)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1249)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1250)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1251)2-(5-amino-2-thienyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1252)2-(5-amino-2-thienyl)-1H-benzimidazol-4-^-6-hydroxyl-2-purinol)amide

(1253)2-(6-methoxyphenyl)-1H-benzimidazol-4-(^-2-hydroxyl-4-pyrimidinyl)amide

(1254)2-(6-methoxyphenyl)-1H-benzimidazol-4-^-6-purinol)amide

(1255)2-(6-methoxyphenyl)-1H-benzimidazol-4-(S-6-hydroxyl-2-purinol)amide

(1256)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1257)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-0^-6-purinol)amide

(1258)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(1^-6-hydroxyl-2-purinol)amide

(1259)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1260)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1261)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1262)2-(2-N-methyl-4-(N-methylpiperazine)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1263)2-(2-N-methyl-4-(N-methylpiperazine)-1H-benzimidazol-4-(N-6-purinol)amide

(1264)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1265)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1266)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-Puri�yl)amide

(1267)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1268)2-N-piperazinyl-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1269)2-N-piperazinyl-1H-benzimidazol-4-(N-6-purinol)amide

(1270)2-N-piperazinyl-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1271)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1272)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1273)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1274)2-thiazolyl-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1275)2-thiazolyl-1H-benzimidazol-4-(N-6-purinol)amide

(1276)2-thiazolyl-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1277)5-thiazolyl-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1278)5-thiazolyl-1H-benzimidazol-4-(N-6-purinol)amide

(1279)5-thiazolyl-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1280)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1281)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1282)2-(2-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1283)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1284)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1285)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1286)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-�hydroxyl-4-pyrimidinyl)amide

(1287)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1288)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1289)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1290)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1291)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1292)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1293)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1294)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1295)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1296)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1297)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1298)2-(2-chinoline)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1299)2-(2-chinoline)-1H-benzimidazol-4-(N-6-purinol)amide

(1300)2-(2-chinoline)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1301)2-(3-chinoline)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1302)2-(3-chinoline)-1H-benzimidazol-4-(N-6-purinol)amide

(1303)2-(3-chinoline)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1304)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1305)2-(2-piperidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1306)2-(2-piperidinyl)-1H-benzimidazol-4-(N-hydroxyl-2-purinol)amide

(1307)2-(3-piperidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1308)2-(3-piperidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1309)2-(3-piperidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1310)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1311)2-(4-piperidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1312)2-(4-piperidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1313)2-(3-indole)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1314)2-(3-indole)-1H-benzimidazol-4-(N-6-purinol)amide

(1315)2-(3-indole)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1316)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1317)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1318)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1319)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1320)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1321)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1322)2-methoxy-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1323)2-methoxy-1H-benzimidazol-4-(N-6-purinol)amide

(1324)2-methoxy-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1325)2-ethoxy-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1326)2-ethoxy-1H-benzimidazol-4-(N-6-purinol)AMI�

(1327)2-ethoxy-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1328)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1329)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-6-purinol)amide

(1330)2-(2,b-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1331)2-pyrazolyl-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1332)2-pyrazolyl-1H-benzimidazol-4-(N-6-purinol)amide

(1333)2-pyrazolyl-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1334)2-(2'-pyridyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1335)2-(2'-pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1336)2-(2'-pyridyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1337)2-(3'-pyridyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1338)2-(3'-pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1339)2-(3'-pyridyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1340)2-(4'-pyridyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1341)2-(4'-pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1342)2-(4'-pyridyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1343)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1344)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1345)2-(2'-imidazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1346)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1347)2-(4-methox�pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1348)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1349)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1350)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1351)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1352)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1353)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1354)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1355)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1356)2-(2-N-methyl-4-N-methylpiperazine)-1H-benzimidazol-4-(N-6-purinol)amide

(1357)2-(2-N-methyl-N-methylpiperazine)-1H-bioimitator-4-(N-6-hydroxyl-2-purinol)amide

(1358)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1359)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1360)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1361)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-(N-2-hydroxyl-4-pyrimidinyl)amide

(1362)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1363)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1364)2-(2-thiazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1365)2-(2-thiazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1366)2-(2-thiazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-purinol)amide

(1367)2-(5-thiazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1368)2-(5-thiazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1369)2-(5-thiazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1370)2-(2-pyridyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1371)2-(2-pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1372)2-(2-pyridyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1373)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1374)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1375)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1376)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-piramidi

nil)amide

(1377)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1378)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1379)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1380)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1381)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1382)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1383)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1384)2-(N-methyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1385)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1386)2-(3,5-�imethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1387)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1388)2-(2-chinoline)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1389)2-(2-chinoline)-1H-benzimidazol-4-(N-6-purinol)amide

(1390)2-(2-chinoline)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1391)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1392)2-(2-piperidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1393)2-(2-piperidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1394)2-(4-piperidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1395)2-(4-piperidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1396)2-(4-piperidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1397)2-(3-indole)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1398)2-(3-indole)-1H-benzimidazol-4-(N-6-purinol)amide

(1399)2-(3-indole)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1400)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1401)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1402)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1403)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1404)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1405)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(S-6-hydroxyl-2-purinol)amide

(1406)2-(2-bromo-5-pyridi�)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1407)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-6-purinol)amide

(1408)2-(2-bromo-5-pyridine)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1409)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1410)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-6-purinol)amide

(1411)2-(2-amino-3-pyridine)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1412)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1413)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1414)2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1415)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1416)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1417)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1418)2-(2-cyclopropylamino)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1419)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1420)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1421)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

(1422)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

(1423)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

(1424)2-(1,3-dim�Teal-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide.

Preferably, the pharmaceutically acceptable salts of the derivatives benzimidazol-4-carboxamide was their inorganic acid salts selected from sulfates, hydrochloride, nitrates, phosphates or borates or organic acid salts selected from citrates, succinates, tartrates, lactates or mesilato.

Another objective of the present invention is to provide pharmaceutical compositions capable protivodeistvovat the Coxsackie virus. The pharmaceutical compositions include a therapeutically effective amount of derivatives of benzimidazol-4-carboxamide or their pharmaceutically acceptable salts according to any one of paragraphs 1 to 7 and one or more pharmaceutically acceptable diluents, auxiliary substances and / or inert carriers.

An additional objective of the present invention is to ensure the application of the derivatives benzimidazol-4-carboxamide or pharmaceutically acceptable salts for the receipt of antiviral drugs, in which viruses are Coxsackie viruses, echoviruses and retrovirus belonging to the family of picornaviruses.

Another objective of the present invention is to provide a method of obtaining derivatives of benzimidazol-4-carboxamide or their pharmaceutically acceptable salts, as shown in the formula (I), wherein the method includes with�next steps:

(1) 2-aminoacetyl-3-nitrobenzoic acid is sequentially subjected to ammonolysis reactions, decomposition of Hoffmann and recovery, resulting in 2,3-diamino-benzoic acid.

(2) 2,3-diamino-benzoic acid condense with aldehydes X-Cho in the presence of a catalyst of cupric acetate and receive benzimidazol-4-carboxylic acid, having the formula (II).

(3) benzimidazol-4-carboxylic acid is reacted with thionylchloride, resulting in acylchlorides, and further by thickening of acylchlorides and amine NHz-Y gain derived benzimidazol-4-carboxamide having the formula (I).

(I) Conditions of occurrence of the above reaction is shown below:

benzimidazol-4-carboxylic acid is reacted with thionylchloride at a temperature of 0-80°C at a molar ratio of thionylchloride to benzimidazole-4-carboxylic acid of 1 to 20, which receive benzimidazol-4-carbonylchloride, and then benzimidazol-4-carbonylchloride reacts with an amine in an organic solvent at a temperature of 0-100°C, to thereby produce derivative benzimidazol-4-carboxamide. In this organic solvent include ethylene dichloride, 1,1,2-trichloroethane, chloroform, tetrachlorethylene, benzene, toluene, xylene, chlorobenzene or dichlorvos�l, etc.

Derivative benzimidazol-4-carboxamide or their pharmaceutically acceptable salt in accordance with the present invention can be administered orally or otherwise. Dosage varies in different medicinal drugs, the dosage is 10-300 mg / day in somatic diseases.

BRIEF description of the DRAWINGS

Fig.1 - spectrogram1H NMR of 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol

-4-carboxylic acid in Example 9.

Fig.2 - spectrogram1H NMR of 2-(5-nitro-2-thienyl)-1H-benzimidazol-4

-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl))amide in Example 21.

Fig.3 - spectrogram1H NMR of 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide in Example 28.

Fig.4 - spectrogram1H NMR (L)-2-(2-pyridyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)amide in Example 194.

Fig.5 - spectrogram1H NMR of 2-(4-hydroxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide in Example 663.

Fig.6 - spectrogram1H NMR (L)-2-(3-hydroxyphenyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)amide in Example 664.

DETAILED DESCRIPTION of the PRESENT INVENTION AND ITS PREFERRED examples of the IMPLEMENTATION

The following is a description of the present invention, in particular, with reference to the examples. Examples are given solely for drawing�and technical solutions of the present invention and should not be construed as limiting the present invention.

The method of obtaining derivatives of benzimidazol-4-amide in accordance with the present invention includes the following steps: using 2-aminoacetyl-3-nitrobenzoic acid as the originating source of the substance, further 2-aminoacetyl-3-nitrobenzoic acid is subjected to ammonolysis, the decomposition of Hoffmann and recovery to obtain the 2,3-diamino-benzoic acid; then the condensation of 2,3-diamino-benzoic acid with aldehydes X-Cho in the presence of a catalyst of cupric acetate to obtain benzimidazol-4-carboxylic acid; further reacting benzimidazole-4-carboxylic acid with thionylchloride to obtain acylchlorides, and, finally, condensation of acylchlorides and Amina "INL-when deriving benzimidazol-4-carboxamid.

Example 1: Synthesis of 2.3-diaminobenzoic acid Step 1: Synthesis of 2-aminoacetyl-3-nitrobenzoic acid

30 g of 3-nitrophthalic anhydride was added to 45 ml of concentrated ammonia at a concentration of 28 g/g%; warmed it up to 60°C with constant stirring for 30 minutes; then cool it to 10°C prior to the deposition of needle-shaped crystals; treated acid needle-like crystals with concentrated hydrochloric acid and was obtained a white solid; further, the substance was filtered, dried and got to 29.4 g of 2-aminoacetyl-3-nitrobenzoic acid.

Step 2: Synthesis of 2-and�Ino-3-nitrobenzoic acid

To 13.9 g of bromine was added dropwise in 100 ml of aqueous sodium hydroxide solution containing 7.3 g of sodium hydroxide in solution. Further to the above solution was added 17 g of 2-aminoacetyl-3 - nitrobenzoic acid; the solution was heated to 80°C to precipitate large amount of solid red; the resulting material was filtered, then processed it with concentrated hydrochloric acid and got a solid yellow color; the resulting material was dried and obtained of 13.7 g of 2-amino-3-nitrobenzoic acid; further, recrystallization was carried out solids yellow by adding hot water and got acicular crystals of yellow color.

Step 3: Synthesis of 2,3-Diaminobenzoic acid

3 g of the above 2-amino-3-nitrobenzoic acid was added to 30 ml of methanol, 20% aqueous sodium hydroxide solution with a molar concentration equivalent to the concentration of 2-amino-3-nitrobenzoic acid was added dropwise to the above solution of methanol until then, until there was complete dissolution. 0.2 g reviewscore Nickel catalyst were simultaneously added into a solution of methanol, the solution was heated to 65°C, was delegirovali at the same temperature; and then was added dropwise 80 g/g% hydrazine hydrate (about 1.5 equivalent weight x 1.1) until then, until it fully disappeared yellow t�et.Hot rineiski Nickel catalyst was filtered; it was further heated and concentrated mother liquor and treated her with concentrated hydrochloric acid, whereby was obtained 2.3 g of 2,3-diaminobenzoic acid red; next, the crude product is 2,3-diaminobenzoic acid was subjected to separation and purification by the method of columnar chromatography.

Example 2: Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazol-4 - carboxylic acid

2.0 g of 2,3-diaminobenzoic acid was dissolved in 60 ml of methanol, and a methanol solution of 5-nitrofurfural was added in methanol with constant stirring. Next, 0.5 g of cupric acetate (Cu(AC)2·H2O) was added to the above-mentioned methanol, heated and delegirovali him; then was filtered hot solution after disappeared 2,3-diaminobenzoic acid. 20% aqueous solution of sodium sulfide was added to the filtrate and heated it to a boil; and then filtered, the precipitate of copper sulfide until the filtrate had a high temperature; and, finally, the filtrate evaporated, dried, purified by the method of columnar chromatography and obtained 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-carboxylic acid. The yield was approximately 65%.

Examples 3-20: Synthesis of intermediate compounds of benzimidazole-4-carboxylic acid

Synthesize benzimidazole-4-carboxylic acid as shown in formula (II) according to the method described in Example 2. The difference is�, in this case, aldehydes are used with different X group, are shown in Table 1. HE

Table 1
No. productsConnectionsXYield, %
42-(2-pyrimidinyl)-1H-benzimidazol-4-carboxylic acid75
52-(2-thienyl)-1H-benzimidazol-4-carboxylic acid76
62-methyl-1H-benzimidazol-4-carboxylic acid72
72-phenyl-1H-benzimidazol-4-carboxylic acid80
82-(4-(dimethylamino)-phenyl)-1H-benzimidazol-4-carboxylic acid 75
92-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-carboxylic acid65

102-(4-methoxy-2-pyridyl)-1H-benzimidazol-4-carboxylic acid68
112-(6-methoxy-2-pyridyl)-1H-benzimidazol-4-carboxylic acid70
122-(4-(dimethylamino)-2-pyridyl)-1H-benzimidazol-4-carboxylic acid75
132-(3-pyridazinyl)-1H-benzimidazol-4-carboxylic acid60
142-(2-piperazinyl)-1H-benzimidazol-4-carboxylic acid61
15 2-(5-amino-4-methyl-2-thiazolyl)-1H-benzimidazol-4-carboxylic acid70
162-(3-chinoline)-1H-benzimidazol-4-carboxylic acid63
172-(2-pyrrolyl)-1H-benzimidazol-4-carboxylic acid75
182-(3-indole)-1H-benzimidazol-4-carboxylic acid71
192-(2-piperidinyl)-1H-benzimidazol-4-carboxylic acid68
202-(2-chinoline)-1H-benzimidazol-4-carboxylic acid70

Structural identification of the products:

(4) 2-(2-pyrimidinyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(t, 1H), 7.67-7.80(t, lH), 7.90-7.9 l(d, 1H), 7.93-7.94(d, 1H), 9.08-9.09(d, 1H), 9.0-9.12(d, 1H);

(5) 2-(2-thienyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 7.15-7.18(t, 1H), 7.41-7.45(t, 1H), 7.68-7.70(d, 1H), 7.85(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(6) 2-methyl-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 2.51(s,3H), 7.41-7.45(t, 1H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H);

(7) 2-phenyl-! N-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 7.41-7.45(t, 1H), 7.38-7.42(t, 1H) 7.50-7.53(t,2H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H), 8.28-8.30(d,2H);

(8) 2-(4-(dimethylamino)-phenyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 3.06(s,6H) 6.82-6.84(d,2H), 7.41-7.45(t, 1H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H), 7.97-7.99(d,2H);

(9) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazol-4-carboxylic acid (see Fig.1)

1H NMR (DMSO, 400MHz) δ: 6.43-6.46 (d, 1H), 7.28-7.32 (t, 1H), 7.77-7.79 (d, 1H), 7.82-7.85 (m, 1H), 8.57(s, 1H), 9.54 (s, 1H), 12.1 l(s, 1H), 13.16(s, 1H);

(10)2-(4-(methoxy)-2-pyridyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.41-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.48-8.49(d, 1H);

(11) 2-(6-methoxy-2-pyridyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 3.80(s,3H), 6.50-6.51(d, 1H), 7.38-7.39(d, 1H), 7.41-7.45(t, 1H), 7.72-7.75(t, 1H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H);

(12)2-(4-(dimethylamino)-2-pyridyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 7.16-7.18(d, 1H), 7.41-7.45(t, 1H), 7.71(s, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.05-8.07(d, 1H);

(13) 2-(3-pyridazinyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 7.41-7.45(t, 1H), 7.61-7.63(t, 1H), 7.89-7.91(d, 1H), 7.937.94(d, 1H), 8.06-8.08(d, 1H), 9.34-9.37(d, 1H);

(14) 2-(2-piperazinyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,2H), 2.60-2.62(m, 1H), 2.65-2.66(m, 1H), 2.67-2.70(m, 1H), 2.72-2.75(m, 1H), 2.84-2.88(m, 1H), 3.09-3.14(m, 1H), 4.14-4.19(m, 1H), 7.41-7.45(t, 1H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H);

(15) 2-(5-amino-4-methyl-2-thiazolyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 1.03-1.09(d,3H), 3.70-3.73(m, 1H), 4.17-4.22(m, 1H), 5.11-5.13(d,2H), 7.41-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(16) 2-(3-chinoline)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 7.41-7.45(t, 1H), 7.60-7.65(t, 1H), 7.78-7.80(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 7.97-7.99(d, 1H), 8.06-8.09(d, 1H), 8.22(s, 1H), 8.57(s, 1H);

(17) 2-(2-pyrrolyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 6.15-6.17(t, 1H), 6.39-6.40(d, 1H), 6.95-6.98(t, 1H), 7.41-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(18) 2-(3-indole)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 7.01-7.05(t, 1H), 7.31-7.34(t, 1H), 7.41-7.45(t, 1H), 7.54-7.56(d, 1H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H), 8.14-8.16(d, 1H), 8.60(s, 1H);

(19) 2-(2-piperidinyl)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 1.47-1.49(m,2H), 1.50-1.55(m,2H), 1.67-1.92(m,2H), 4.01-4.03(m, 1H), 7.41-7.45(t, 1H). 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(20) 2-(2-chinoline)-1H-benzimidazol-4-carboxylic acid

1H NMR (DMSO, 400MHz) δ: 1.43-1.45(m, 1H), 1.46-1.47(m, 1H), 1.49-1.51(m, 1H), 1.53-1.55(m, 1H), 1.67-1.70(m, 1H), 1.92-1.96(m, 1H), 2.69-2.7 l(m, 1H), 2.78-2.80(m, 1H), 4.01-4.03(m, 1H), 7.41-7.45(t, 1H), 7.89-7.9 l(d, 1H), 7.93-7.94(d, 1H)o

Example 21: Synthesis of (b)-2-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-(l-gidroximetil-2-p-nitrophenyl hydrox�ethyl)amide

1.0 g of 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-carboxylic acid in Example 2 was added to 15 ml of thionylchloride, and the reaction between the two compounds proceeded for 60 minutes, after the reaction is completed (b)-2-amino-1-p-nitrophenyl-1,3-propylenglykol (1,1 EQ.) was added to the reaction mixture with constant stirring for 2 hours at room temperature;

next were filtered off an inorganic salt, evaporated the solvent to dry condition and received the final product 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)amide. The yield was approximately 93%. Spectrum of1H NMR is shown in Fig.2.

Structural identification of the product:

1H NMR(DMSO,400MHz) δ:3.59-3.60(m, 1H),3.65-3.67(t, 1H),4.16-4.22(q, 1H),5.07-5.08(t, 1H),5.27-5.28(t, 1H),6.16-6.17(d, 1H),7.35-7.39(t, 1H),7.53-7.54(d, 1H),7.72-7.75(m,2H),7.77-7.79 (m,2H),8.00-8.01 (d, 1 H),8.05-8.07(d,3H), 10.04-10.06 (d,2H), 14.05 (s, 1H).

Example 22: Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-(1-methyl-2-p-chlorophenyl hydroxyethyl)amide

1.0 g of 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-carboxylic acid was added to 15 ml of thionylchloride; the mixture was heated and delegirovali within 60 minutes.After completion of the reaction of 2-amino-1-p-chlorophenyl-1-propanol (1.1 EQ.) was dissolved in tetrahydrofuran, and then was added dropwise acylchlorides to the above mentioned mixture of tetrahydrofuran under constant stirring at room temperature,was filtered inorganic salt, the evaporated solvent to dry condition, then the mixture was separated by the method of columnar chromatography and obtained 2-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)amide. The yield was approximately 92%.

Structural identification of the product:

1H NMR (DMSO, 400MHz) δ: 1.10-1.16(d,3H), 3.26-3.28(m, 1H), 3.64-3.66(d, 1H), 4.71-4.74(m, 1H), 7.28-7.30(d,2H), 7.35-7.38(d,2H), 7.41-7.45(t, 1H), 7.56-7.58(d, 1H), 7.62-7.68(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H).

Examples 23-67:

Use a similar process as in Example 22, to synthesize compounds are shown in Table 2.

Table 2

No.ConnectionsXYYield, %
232-(2-pyridyl)-1H-benzimidazol-4-N-hydroxyethylamide88
242-(2-pyridyl)-1H-benzimidazol-4-N-o-hydroxypolycarboxylic80

252-(2-hydroxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide82
26(L)-2-(2-hydroxyphenyl)-1H-Benzi midazol-4-[N-(1-hydroxyl-2-p-nitrophenyl hydroxyethyl)]amide91
272-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide90
282-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide89
292-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
302-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-hydroxyethyl)amide86
312-(2-piperidinyl)-1H-benzimidazol-4-(4-N'-ethyl-N-piperazinyl)amide95
322-(2-pyridyl)-1H-benzimidazol-4-(4-N'-ethyl-N-piperazinyl)amide94

33(L)-2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide90
34(L)-2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide 89
352-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
362-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-N'-piperidinyl)amide90
372-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-piperazinyl)amide89
382-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide91
392-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-o-Dapsone base)amide 88
402-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide87

412-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide90
422-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide87
432-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide87
442-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyrazinyl)amide 90
452-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide91
462-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyridyl)amide93
472-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide90
482-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide85
492-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide/td> 94

502-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide88
512-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide90
522-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N'-o-fluorophenyl)amide93
532-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide86
54 2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-6-purinol)amide90
552-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-6-hydroxy-2-purinol)amide91
56(L)-2-(2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide90
57(L)-2-(2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide92
582-(2-thienyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide92

592-(2-thienyl)-1H-benzimidazol-4-(N-M'-piperidinyl)amide91602-(2-thienyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide88612-(2-thienyl)-1H-benzimidazol-4-(N-2' -benzimidazolyl)amide93622-(2-thienyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide94632-(2-thienyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide90642-(2-thienyl)-1H-b�Intimidator-4-(N-4'-carbonamide-5'-imidazolyl)amide 94652-(2-thienyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide92662-(2-thienyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide94672-(2-thienyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide94682-(2-thienyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93692-(2-thienyl)-1H-benzimidazol-4-(N-2-pyridyl)amide 90702-(2-thienyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide91

712-(2-thienyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidiny l)amide93
722-(2-thienyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide93
732-(2-thienyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide88
742-(2-thienyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide 89
752-(2-thienyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide87
762-(2-thienyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide92
772-(2-thienyl)-1H-benzimidazol-4-(N-6-purinol)amide90
782-(2-thienyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide91
79(L)-2-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide 93
80(L)-2-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide93

812-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide94
822-(4-methoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide90
832-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
842-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide 92
852-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide91
862-(4-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide91
872-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide93
882-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide92
892-(4-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide 93
902-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide94
912-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
922-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide92

932-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93
942-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 94
952-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90
962-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide94
972-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide92
982-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94
992-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide 94
1002-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide93
1012-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide90
102(L)-2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide91
103(L)-2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-R-aminophenylacetate)]amide93

1042-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide 93
1052-(6-methoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide94
1062-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide89
1072-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide93
1082-(6-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide92
1092-(6-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide 90
1102-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide89
1112-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide93
1122-(6-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide93
1132-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide94

1142-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide 90
1152-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide93
1162-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide92
1172-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide86
1182-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide91
1192-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 90
1202-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide92
1212-(6-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
1222-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide87
1232-(6-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide92

1242-(6-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-purinol) amide 88
125(L)-2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-hydroxy methyl-2-p-nitrophenyl hydroxyethyl)]amide93
126(L)-2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-hydroxy methyl-2-p-Dapsone base hydroxyethyl)]amide94
1272-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
1282-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide94
129 2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide92
1302-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide94
1312-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide94

139
1322-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide93
1332-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide 86
1342-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide91
1352-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide93
1362-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide93
1372-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide88
1382-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide89
2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(TM-4-methyl-5-thiazolyl)amide87
1402-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide88

1412-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90
1422-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide89
1432-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide 93
1442-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
1452-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide88
1462-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-6-purinol)amide90
1472-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide93
148(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide 92

149(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91
1502-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-(1-methyl-2-p-chloro phenyl hydroxyethyl)]amide91
1512-(2,3,4-trimethoxyphenyl)-1H-benzo imidazole-4-(N-N'-piperidinyl)amide93
1522-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide92
1532-(2,3,4-trimethoxyphenyl)-N-benzimidazol-4-(N-2'-benzimidazolyl)amide 93
1542-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide90
1552-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide92
1562-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide87
1572-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide93
1582-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide 94

1592-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide90
1602-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide94
1612-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide92
1622-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide94
1632-(2,3,4-trimethoxyphenyl)-1H-Benzi�idazole-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 94
1642-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide93
1652-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide90
1662-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide91
1672-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
1682-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-GI�Roxy-4-pyrimidinyl)amide 89

1692-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide88
1702-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide89
171(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide87
172(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
1732-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
1742-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide91
1752-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
1762-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimida azolyl)amide93

1772-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide 94
1782-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzamid of asolani)amide90
1792-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide86
1802-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide92
1812-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-[-(N'-piperazinyl))amide91
1822-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide91
1832-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
1842-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide92
1852-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93

1862-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide89
1872-(3-hydroxyl-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 92
1882-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide92
1892-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
1902-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94
1912-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide90
1922-(3-hydroxyl-4-methoxy�enyl)-1H-benzimidazol-4-(N-6-purinol)amide 94
1932-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide89
194(L)-2-(2-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide94

195(L)-2-(2-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
1962-(2-pyridyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide93
1972-(2-pyridyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide90
1982-(2-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide91
1992-(2-pyridyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide93
2002-(2-pyridyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide89
2012-(2-pyridyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide88
2022-(2-pyridyl)-1H-benzimidazol-4-(N-4'-�bonamigo-5'-imidazolyl)amide 86
2032-(2-pyridyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide87
2042-(2-pyridyl)-1H-benzimidazol-4-(N - [- (N'-piperazinyl))amide92
2052-(2-pyridyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide90

2062-(2-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide91
2072-(2-pyridyl)-1H-benzimidazol-4-(N-2-pyridyl)amide 93
2082-(2-pyridyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93
2092-(2-pyridyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide88
2102-(2-pyridyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90
2112-(2-pyridyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide93
2122-(2-pyridyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide 92
2132-(2-pyridyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide91
2142-(2-pyridyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide91
2152-(2-pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide93

2162-(2-pyridyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide88
217(L)-2-(3-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide 93
218(L)-2-(3-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide94
2192-(3-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide92
2202-(3-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
221(L)-2-(4-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide93
222(L)-2-(4-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide 94
2232-(4-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90
2242-(4-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide94
225(L)-2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92

226(L)-2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91
2272-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-CL�henil hydroxyethyl)]amide 94
2282-(3-pyridazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide93
2292-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90
2302-(3-pyridazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide91
2312-(3-pyridazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide93
2322-(3-pyridazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide 93
2332-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide86
2342-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide89
2352-(3-pyridazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide87

2362-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide92
2372-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide 90
2382-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide91
2392-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93
2402-(3-pyridazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide89
2412-(3-pyridazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide94
2422-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 90
2432-(3-pyridazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
2442-(3-pyridazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide92
2452-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide88

td align="center">
2462-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-purinol)amide91
2472-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide87
248(L)-2-(4-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92
249(L)-2-(4-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
2502-(4-pyridazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide94
2512-(4-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
252(L)-2-(2-pyrazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide 92
253(L)-2-(2-pyrazinyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide89
2542-(2-pyrazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide94

2552-(2-pyrazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide90
2562-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide94
2572-(2-pyrazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide92
2582-(2-pyrazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide90
2592-(2-pyrazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide94
2602-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide87
2612-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide90
2622-(2-pyrazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide 91
2632-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide93
2642-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
2652-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide88

2662-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide89
2672-(2-pyrazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 87
2682-(2-pyrazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide92
2692-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide90
2702-(2-pyrazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide91
2712-(2-pyrazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
2722-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide 89
2732-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-purinol)amide94
2742-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide89

275(L)-2-(2-piperazinyl)-1H-benim idazole-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide93
276(L)-2-(2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
2772-(2-piperazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide 91
2782-(2-piperazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide91
2792-(2-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
2802-(2-piperazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide92
2812-(2-piperazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide93
2822-(2-piperazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide94

2832-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide89
2842-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide92
2852-(2-piperazinyl)-1H-benzimidazol-4-(N-(N-piperazinyl))amide92
2862-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide92
2872-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide 93
2882-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide92
2892-(2-piperazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide91
2902-(2-piperazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide87
2912-(2-piperazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90

2922-(2-piperazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 88
2932-(2-piperazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
2942-(2-piperazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94
2952-(2-piperazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide89
2962-(2-piperazinyl)-1H-benzimidazol-4-(N-6-purinol)amide90
2972-(2-piperazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide 87
298(L)-2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide90
299(L)-2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91
3002-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90

3012-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide91
302(L)-2-(N-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2P-nitrophenyl hydroxyethyl)]amide 92
303(L)-2-(N-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91
3042-(N-piperazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide92
3052-(N-piperazinyl)-1H-benzimidazol-4-(N-N' -piperidinyl)amide93
3062-(N-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide91
3072-(N-piperazinyl)-1H-benzimidazol-4-(N-2'-benzimidazol�l)amide 92
3082-(N-piperazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide90

3092-(N-piperazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide91
3102-(N-piperazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide90
3112-(N-piperazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide93
3122-(N-piperazinyl)-1H-benzimidazol-4-(N-(N-�piperazinyl))amide 91
3132-(N-piperazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide92
3142-(N-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
3152-(N-piperazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide94
3162-(N-piperazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide94
3172-(N-piperazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 88

3182-(N-piperazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90
3192-(N-piperazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide91
3202-(N-piperazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
3212-(N-piperazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
3222-(N-piperazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide 88
3232-(N-piperazinyl)-1H-benzimidazol-4-(N-6-purinol)amide89
3242-(N-piperazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide87
325(L)-2-(N-ethyl-N'-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92
326(L)-2-(N-ethyl-N'-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide93

327 2-(N-ethyl-N'-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide92
3282-(N-ethyl-N'-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
329(L)-2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92
330(L)-2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91
3312-(2-pyrrol�l)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide 92
3322-(2-pyrrolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide93
3332-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90
3342-(2-pyrrolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide93
3352-(2-pyrrolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide 90
3362-(2-pyrrolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide91
3372-(2-pyrrolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide85
3382-(2-pyrrolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide90
3392-(2-pyrrolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide92
3402-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide95
3412-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide94
3422-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide94
3432-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide95
3442-(2-pyrrolyl)-1H-Ben�imidazole-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 87

3452-(2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide94
3462-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide91
3472-(2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
3482-(2-pyrrolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94
3492-(2-PI�roll)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide 86
3502-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide92
3512-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide87
352(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide93
353(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-RM-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91

2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide93
3552-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide94
3562-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90
3572-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide94
3582-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide93
3592-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-5-benzimidazo of lonil)amide94
3602-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide90
3612-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide94
3622-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide92

3632-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide 94
3642-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide94
3652-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide93
3662-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide90
3672-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide91
3682-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 93
3692-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide93
3702-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide88
3712-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide89

3722-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide87
3732-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-purinol)amide 92
3742-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide90
375(L)-2-(2-chinoline)-1H-benzimida Azol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide91
376(L)-2-(2-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide93
3772-(2-chinoline)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide93
3782-(2-chinoline)-1H-benzimidazol-4-(N-N'-piperidinyl)amide 94
3792-(2-chinoline)-1H-benzimidazol-4-(N-2-piperazinyl)amide90

3802-(2-chinoline)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide93
3812-(2-chinoline)-1H-benzimidazol-4-(N-o-Dapsone base)amide92
3822-(2-chinoline)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide91
3832-(2-chinoline)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazole yl)amide 91
3842-(2-chinoline)-1H-benzimidazol-4-(N-4' -pyrazolyl)amide93
3852-(2-chinoline)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide92
3862-(2-chinoline)-1H-benzimidazol-4-(N-2-pyrazinyl)amide93
3872-(2-chinoline)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide94
3882-(2-chinoline)-1H-benzimidazol-4-(N-2-pyridyl)amide 92

3892-(2-chinoline)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide92
3902-(2-chinoline)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide87
3912-(2-chinoline)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide94
3922-(2-chinoline)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide93
3932-(2-chinoline)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide 93
3942-(2-chinoline)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
3952-(2-chinoline)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide88
3962-(2-chinoline)-1H-benzimidazol-4-(N-6-purinol)amide90
3972-(2-chinoline)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide85

398(L)-2-(3-chinoline)-1H-benzimida Azol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide 93
399(L)-2-(3-chinoline)-1H-benzimidazole-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide91
4002-(3-chinoline)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
4012-(3-chinoline)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
402(L)-2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide91
403(L)-2-(2-piperidinyl)-1H-benim idazole-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide 89
4042-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide91
4052-(2-piperidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide92
4062-(2-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90

4072-(2-piperidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide93
4082-(2-piperidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide 93
4092-(2-piperidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide93
4102-(2-piperidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide85
4112-(2-piperidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide89
4122-(2-piperidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide87
4132-(2-piperidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide 93
4142-(2-piperidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
4152-(2-piperidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide91

4162-(2-piperidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93
4172-(2-piperidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide88
4182-(2-piperidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide93
4192-(2-piperidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide89
4202-(2-piperidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
4212-(2-piperidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide92
4222-(2-piperidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide86
4232-(2-piperidinyl)-1H-benzimidazol-4-(N-6-purinol)amide 91
4242-(2-piperidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide89

425(L)-2-(3-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide93
426(L)-2-(3-piperidinyl)-1H-benim idazole-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
4272-(3-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90
4282-(3-piperidinyl)-1H-benzimidazo�-4-(N-2-pyrimidinyl)amide 94
429(L)-2-(4-piperidinyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92
430(L)-2-(4-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
4312-(4-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide91
4322-(4-piperidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
433(L)-2-(3-indole)-1H-benzimidazol-4-[N-(1-guide�hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide 93

434(L)-2-(3-indole)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide88
4352-(3-indole)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
4362-(3-indole)-1H-benzimidazol-4-(N-N'-piperidinyl)amide94
4372-(3-indole)-1H-benzimidazol-4-(N-2-piperazinyl)amide92
4382-(3-indole)-1H-b�Intimidator-4-(N-2'-benzimidazolyl)amide 90
4392-(3-indole)-1H-benzimidazol-4-(N-o-Dapsone base)amide91
4402-(3-indole)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide93
4412-(3-indole)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide93
4422-(3-indole)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide88

4432-(3-indole)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide89
4442-(3-indole)-1H-benzimidazol-4-(N-2-pyrazinyl)amide94
4452-(3-indole)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
4462-(3-indole)-1H-benzimidazol-4-(N-2-pyridyl)amide93
4472-(3-indole)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide91
4482-(3-indole)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 87
4492-(3-indole)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide93
4502-(3-indole)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide88
4512-(3-indole)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide92

4522-(3-indole)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94
4532-(3-indole)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide 86
4542-(3-indole)-1H-benzimidazol-4-(N-6-purinol)amide90
4552-(3-indole)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide86
456(L)-2-(2'-imidazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide93
457(L)-2-(2'-imidazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide93
4582-(2'-imidazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide 88
4592-(2'-imidazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide93
4602-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide90

4612-(2'-imidazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide94
4622-(2'-imidazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide86
4632-(2'-imidazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide 90
4642-(2'-imidazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide86
4652-(2'-imidazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide93
4662-(2'-imidazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide93
4672-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide94
4682-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide 93
4692-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide90

4702-(2'-imidazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide94
4712-(2'-imidazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide86
4722-(2'-imidazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide94
4732-(2'-imidazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 86
4742-(2'-imidazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
4752-(2'-imidazolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
4762-(2'-imidazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide88
4772-(2'-imidazolyl)-1H-benzimidazol-4-(N-6-purinol)amide93
4782-(2'-imidazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide87

479(L)-2-(3-pyrazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide94
480(L)-2-(3-pyrazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide86
4812-(3-pyrazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
4822-(3-pyrazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide94
4832-(3-pyrazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide 93
4842-(3-pyrazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide93
4852-(3-pyrazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide88
4862-(3-pyrazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide93
4872-(3-pyrazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide87

4882-(3-pyrazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide 94
4892-(3-pyrazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide86
4902-(3-pyrazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide90
4912-(3-pyrazolyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide86
4922-(3-pyrazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide93
4932-(3-pyrazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93
4942-(3-pyrazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide88
4952-(3-pyrazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide93
4962-(3-pyrazolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide88

4972-(3-pyrazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide94
4982-(3-pyrazolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide 93
4992-(3-pyrazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide90
5002-(3-pyrazolyl)-1H-benzimidazol-4-(N-6-purinol)amide86
5012-(3-pyrazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide89
502(L)-2-(2-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide93
503(L)-2-(2-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide 88
5042-(2-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide93

5052-(2-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide90
5062-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide94
5072-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide92
5082-(2-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amideimg src="http://img.russianpatents.com/1213/12139575-s.jpg" height="14" width="20" /> 90
5092-(2-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide86
5102-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide87
5112-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide93
5122-(2-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide88
5132-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide93

5142-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide90
5152-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide94
5162-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide93
5172-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide90
5182-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide 86
5192-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide93
5202-(2-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
5212-(2-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
5222-(2-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide88

5232-(2-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide90
5242-(2-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide86
525(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide90
526(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
5272-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide86
5282-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide 93
5292-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(1-2-piperazinyl)amide93
5302-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide88

5312-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide93
5322-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide90
5332-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazole�)amide 94
5342-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-pyrazolyl)amide90
5352-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide90
5362-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide86
5372-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide93
5382-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide 93
5392-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide88

5402-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide93
5412-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90
5422-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide94
5432-(2-f�Neal-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide 94
5442-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide90
5452-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide86
5462-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide93
5472-(2-phenyl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide93
548(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-hydroxymet�l-2-p-nitrophenyl hydroxyethyl)]amide 88

549(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide93
5502-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
5512-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide94
5522-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide86
5532-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide90
5542-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide86
5552-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide93
5562-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide86
5572-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide 88

5582-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperazinyl))amide93
5592-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide90
5602-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide90
5612-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide86
5622-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide 90
5632-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide86
5642-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide90
5652-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide90
5662-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide88

5672-(4-�Mino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide 93
5682-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydro KSIL-4-pyrimidinyl)amide90
5692-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide91
5702-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide93
571(L)-2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide94
572()-2-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide 90
5732-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide94
5742-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide92

5752-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide94
5762-(2-pyrrolidin-1-yl-5-pyrimid inyl)-1H-benzimidazol-4-(N-N'-benzimidazolyl)amide94
5772-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide93
5782-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide90
5792-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide85
5802-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide93
5812-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide 93
5822-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide88
5832-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide89

5842-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide87
5852-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide92
5862-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide 90
5872-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide91
5882-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide93
5892-(2-pyrrolidin-1-yl-5-pyrimid inyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
5902-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94
5912-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-HYDR�KSIL-4-pyrimidinyl)amide 90
5922-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide93

5932-(2-pyrrolidin-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide92
594(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide91
595(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide 91
5962-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl l-2-p-chlorophenyl hydroxyethyl)]amide93
5972-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide92
5982-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
5992-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-benzimidazolyl)amide94
6002-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide 92
6012-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide92

6022-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide85
6032-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide94
6042-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide90
6052-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide 94
6062-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
6072-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide94
6082-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide94
6092-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide93
6102-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-d�methoxy-2-pyrimidinyl)amide 90

6112-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide91
6122-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide93
6132-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide93
6142-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide88
6152-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-purinol)amide89
6162-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide87
617(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92
618(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide90
6192-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide 91

6202-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide93
6212-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
6222-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-benzimidazolyl)amide94
6232-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide90
6242-(2-cyclopropylamino-5-Piri�idini)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide 93
6252-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide92
6262-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-N'-pyrazolyl)amide91
6272-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide91
6282-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide93

6292-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide92
6302-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide93
6312-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide94
6322-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide92
6332-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 92
6342-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide93
6352-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide94
6362-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide90
6372-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide94

643
6382-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N6-purinol)amide 92
6392-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide94
640(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide94
641(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide93
6422-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide90
2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide91
6442-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide93
6452-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-N'-benzimidazolyl)amide93

6462-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide88
6472-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide 89
6482-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide87
6492-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide92
6502-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide90
6512-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-piraz inil)amide91
6522-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-pyrim idini)amide 93
6532-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide93
6542-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide94

6552-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide90
6562-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide93
6572-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N4-chloro-6-amino-2-pyrimidinyl)amide 92
6582-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide91
6592-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide91
6602-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide93
6612-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazol-4-(N-6-purinol)amide92
6622-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-�benzimidazol-4-(N-6-hydroxyl-2-purinol)amide 93
6632-(4-hydroxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide94

664(L)-2-(3-hydroxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide92
6652-(3-hydroxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide92

Structural identification of the product (see Fig.3-6);

(23)2-(2-pyridyl)-1H-benzimidazol-4-N-hydroxyethylamide

1H NMR (DMSO, 400MHz) δ: 3.64-3.67(t, 1H), 3.73-3.75(m,2H), 4.39-4.42(t,2H), 7.32-7.36(t, 1H), 7.38-7.40(1,1 H), 7.73-7.75(d, 1H), 7.80-7.81(d, 1H), 7.85-7.86(t, 1H), 8.38-8.40(d, 1H), 8.59-8.61 (d, 1H);

(24)2-(2-pyridyl)-1H-benzimidazol-4-N-o-hydroxypolycarboxylic

H NMR (DMSO, 400MHz) δ: 5.35(s, 1H), 7.13(s, 1H), 7.15-7.16(d,2H), 7.34-7.36(t,3H), 7.37-7.39(t, 1H), 7.83-7.84(d, 1H), 7.85-7.86(t, 1H), 7.91-7.92(d, 1H), 8.11-8.12(d, 1H), 8.38-8.40(d, 1H),8.59-8.61(d, 1H);

(25)2-(2-hydroxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 5.35(s, 1H), 6.59-6.61(d, 1H), 6.63-6.64(t, 1H), 6.95-6.97(t, 1H), 6.99-7.00(d, 1H), 7.01-7.02(d, 1H),' 7.07-7.09(t, 1H), 7.24-7.25(t, 1H), 7.37-7.39(t, 1H), 7.62-7.63(d, 1H), 7.83-7.84(d, 1H), 7.91-7.92(d, 1H);

(26)(b)-2-(2-hydroxyphenyl)-1H-benzimidazol-4-[1H-(1-hydroxyl-2-p-nitrophenyl hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 5.35(s, 1H), 7.01-7.02(d, 1H), 7.07-7.09(t, 1H), 7.24-7.25(d, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.66-7.67(d, 1H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H);

(27)2-(5-nitro-2-thienyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.46(t, 1H), 7.70-7.72(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.95(d, 1H), 8.30-8.33(d, 1H), 8.57-8.60(d, 1H), 11.53(s, 1H);

(28)2-(5-nitro-2-thienyl)-1H-benzimidazol-4-N-o-fluorophenyl)amide (see Fig.3)

1H NMR(DMSO,400MHz)δ:7.13-7.19(m, I H),7.23-7.27(t, I H),7.36-7.41 (t, I H),7.50-7.54(m,2 H), 7.85-7.87(d, 1H), 7.94-7.95(d, 1H), 8.05-8.07(d, 1H), 8.57-8.61(t, 1H), 12.19-12.20(d, 1H), 14.25(s, 1H);

(29)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 5.33(s, 1H), 5.35(s, 1H), 5.38(s, 1H), 6.59-6.61(d, 1H), 6.63-6.64(1,1 H), 6.71(s,2H), 6.95-6.97(1,1 H), 6.99-7.01(d, 1H), 7.43-7.45(t, 1H), 7.90-7.91(d, 1H), 7.93-7.94(d, 1H);

(30)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazol-4-N-hydroxyethyl)amide

1H NMR (DMSO, 400MHz) δ: 5.33(s, 1H), 5.35(s, 1H), 5.38(s, 1H), 2.84-2.88(m,2H), 3.59-3.62(m,2H), 3.65-3.67(t, 1H), 6.71(s,2H), 7.43-7.45(t, 1H), 7.89-7.90 (d, 1H), 7.93-7.94(d, 1H);/p>

(31)2-(2-piperidinyl)-1H-benzimidazol-4-(4-N'-ethyl-N-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.05(t,3H), 1.43-1.44(m, 1H), 1.45-1.47(m, 1H), 1.49-1.52(m, 1H), 1.55-1.57(m, 1H), 1.67-1.69(m1H), 1.91-1.94(m, 1H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 2.69-2.72(m, 1H), 2.79-2.8 l(m, 1H), 4.02-4.04(m, 1H), 7.43-7.45(t, 1H), 7.90-7.91 (d, 1H), 7.93-7.94(d, 1H);

(32)2-(2-pyridyl)4H-benzimidazol-4-(4-N'-ethyl-N-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.05(t,3H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 7.36-7.38(t,H), 7.43-7.45(t, 1H), 7.85-7.86(t, 1H), 7.90-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.38-8.39(d, 1H), 8.59-8.61(d, 1H);

(33)(b)-2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-gidroximetil-2-R nits Ravenel hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) S: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.17-3.18(m, 1H), 3.19-3.20(d, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(1,1 H), 7.62-7.65(d,2H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H);

(34)(b)-2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-gidroximetil-2-R-AMI nofeel hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.17-3.18(m, 1H), 3.19-3.20(d, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(1,1 H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(1,1 H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H);

(35)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 1.70(s, 1H), 1.82(s, 1H), 1.85(s.1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 3.25-3.28(m, 1H), 3.65-3.68(t, 1H), 4.73-4.77(1,1 H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t, 1H), 7.89-7.91 (d, 1H),7.93-7.94(d, 1H);

(36)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.10-3.15(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(1,1 H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H);

(37)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 1.91-1.93(m,2H), 2.00-2.06(t,4H), 2.62-2.63(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.19-3.20(d, 1H), 3.99-4.0 l(m, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(38)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(39)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 6.27(s,2H), 6.38-6.40(d, 1H), 6.56-6.58(t, 1H), 6.75-6.76(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(1,1 H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H);

(40)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 6.35-6.37(d, 1H), 6.93(s, 1H), 7.43-7.45(t, 1H), 7.54-7.56(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(41)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazole l)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s.1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H),7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.37(s,2H), 9.24-9.26(d, 1H), 13.00-13.03(d, 1H);

(42)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.61(s, 1H), 8.63-8.65(d, 1H), 13.71-13.75(d, 1H);

(43)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 1.91-1.95(m, 1H), 2.00-2.06(t,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.90-7.91 (d, 1H), 7.93-7.94(d, 1H);

(44)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.34-8.35(d, 1H), 8.36(s, 1H), 8.40-8.42(d, 1H);

(45)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 6.93-6.95(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.45-8.46(d,2H);

(46)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 6.62-6.64(t, 1H), 6.70-6.72(d, 1H), 7.43-7.45(t, 1H), 7.55-7.57(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.07-8.09(d, 1H);

(47)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 2.45(s,3H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1), 8.12(s, 1H);

(48)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidine yl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(1,1 H), 7.43-7.45(1,1 H), 7.82(s, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.33(s, 1H), 11.53(s, 1H);

(49)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 3.82(s,6H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 5.71(s, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H),7.93-7.94(d, 1H);

(50)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidine yl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t.4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 5.98(s, 1H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(51)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H),9.34(s, 1H);

(52)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 6.60-6.61 (d, 1H), 6.63-6.65(t, 1H), 6.96-6.98(t, 1H), 6.99-7.01 (d, 1H), 7.43-7.45(1,1 H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(53)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl) amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 5.46-5.48(d, 1H), 7.10-7.11(d, 1H), 7.43-7.45(t, 1H), 7.82(s, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, H);

(54)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.86-7.88(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.16-8.18(d, 1H);

(55)2-(2,6-dimethyl-2,6-octadienal)-1H-benzimidazol-4-(N-6-hydroxy-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 1.70(s, 1H), 1.82(s, 1H), 1.85(s, 1H), 2.00-2.06(t,4H), 3.19-3.20(d, 1H), 5.13-5.15(t, 1H), 5.20-5.23(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.57-8.59(d, 1H), 11.53(s, 1H);

(56)(b)-2-(2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H). 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H);

(57)(b)-2-(2-thienyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H);

(58)2-(2-thienyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenylacetyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m, 1H), 3.65-3.68(t, 1H), 4.73-4.77(t, 1H), 7.17-7.19(t, 1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(59)2-(2-thienyl)4H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(60)2-(2-thienyl)-1H-benzimidazol-4-(1H-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.0 l(m, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(61)2-(2-thienyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.12-7.15(d,2H), 7.17-7.19(t, 1H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(62)2-(2-thienyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 6.27(s,2H), 6.38-6.40(d, 1H), 6.56-6.58(t, 1H), 6.75-6.76(d, 1H), 7.02-7.04(t, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(63)2-(2 - thienyl)-1H-benzimidazol-4-^-5 - benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.35-6.37(d, 1H), 6.93(s, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.54-7.56(d, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H),

(64)2-(2-thienyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(1,1 H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.37(s,2H), 9.24-9.26(d, 1H), 13.00-13.03(d.1H);

(65)2-(2-thienyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.61(s, 1H), 8.63-8.65(d, 1H), 13.71-13.75(d, 1H);

(66)2-(2-thienyl)-1H-benzimidazol-4-(N-N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m, 1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.90-7.91 (d, 1H), 7.93-7.94(d, 1H);

(67)2-(2-thienyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(1,1 H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.9-7.91(d, 1H), 7.93-7.94(d, 1H), 8.34-8.35(d, 1H), 8.36(s, 1H), 8.40-8.42(d, 1H);

(68)2-(2-thienyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) 6: 6.93-6.95(t, 1H), 7.17-7.19(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.45-8.46(d,2H);

(69)2-(2-thienyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 6.62-6.64(t, 1H), 6.70-6.72(d, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.55-7.57(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.07-8.09(d, 1H);

(70)2-(2-thienyl)-1H-benzimidazol-4-(1^-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.12(s, 1H);

(71)2-(2-thienyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.82(s, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.33(s, 1H), 11.53(s, 1H);

(72)2-(2-thienyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.82(s,6H), 5.71(s, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(73)2-(2-thienyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.98(s, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.74(s,2H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(74)2-(2-thienyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 9.34(s, 1H);

(75)2-(2-thienyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 6.60-6.61(d, 1H), 6.63-6.65(t, 1H), 6.96-6.98(t, 1H), 6.99-7.01 (d, 1H), 7.17-7.19(t, 1H), 7.43-7.45(1,1 H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H),7.93-7.94(d, 1H);

(76)2-(2-thienyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.46-5.48(d, 1H), 7.10-7.11(d, 1H), 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71(d, 1H), 7.82(s, 1H), 7.85-7.87(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(77)2-(2-thienyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.86(d, 1H), 7.87-7.88(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.16-8.18(d, 1H);

(78)2-(2-thienyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.17-7.19(t, 1H), 7.43-7.45(t, 1H), 7.69-7.71 (d, 1H), 7.85-7.87(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.57-8.59(d, 1H), 11.53(s, 1H);

(79)(b)-2-(4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 3.83(s,3H), 4.73-4.77(t, 1H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61 (d, 1H), 7.62-7.65(d,2H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H), 8.49-8.51(d, 1H);

(80)(b)-2-(4-methoxyphenyl)-1H-benzimidazol-4-^-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 3.83(s,3H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61 (d, 1H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.49-8.51(d, 1H);

(81)2-(4-methoxyphenyl)-1H-benzimidazol-4-[1^-(1-methyl-2-p-chlorophenyl hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m, 1H), 3.65-3.68(t, 1H), 3.83(s,3H), 4.73-4.77(t, 1H), 7.29-7.30(d,2H), 7.31(s, 1H), 7.40-7.41 (d,2H), 7.43-7.45(t, 1H), 7.59-7.61 (d, 1H),7.89-7.91 (d, 1H), 7.93-7.94(d.1H), 8.49-8.51 (d, 1H);

(82)2-(4-methoxyphenyl)-1H-benzimidazol-4-^-1H'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15 (t,4H), 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61 (d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51(d, 1H);

(83)2-(4-methoxyphenyl)-1H-benzimidazol-4-(^2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.83(s,3H), 3.99-4.0 l(m, 1H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H);

(84)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51(d, 1H);

(85)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 6.27(s,2H), 6.38-6.40(d, 1H), 6.56-6.58(t, 1H), 6.75-6.76(d, 1H), 7.02-7.04(1,1 H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H);

(86)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 6.35-6.37(d, 1H), 6.93(s, 1H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.54-7.56(d, 1H), 7.59-7.61 (d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51(d, 1H);

(87)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61 (d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.37(s,2H), 8.49-8.51(d, 1H), 9.24-9.26(d, 1H), 13.00-13.03(d, 1H);

(88)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H), 8.61(s, 1H), 8.63-8.65(d, 1H), 13.71-13.75(d, 1H);

(89)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m, 1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.90-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H);

(90)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.34-8.35(d, 1H), 8.36(s, 1H), 8.40-8.42(d, 1H), 8.49-8.51(d, 1H);

(91)2-(4-methoxyphenyl)-1H-benzimidazol-4-^-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 6.93-6.95(1,1 H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.45-8.46(d,2H), 8.49-8.51(d, 1H);

(92)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 6.62-only 6.64(t, 1H), 6.70-6.72(d, 1H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.55-7.57(1,1 H), 7.59-7.61 (d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.07-8.09(d, 1H), 8.49-8.51(d, 1H);

(93)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.12(s, 1H), 8.49-8.51(d, 1H);

(94)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61(d, 1H), 7.82(s, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.33(s, 1H), 8.49-8.51(d, 1H), 11.53(s, 1H);

(95)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.82(s,6H), 3.85(s,3H), 5.71(s, 1H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61 (d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51(d, 1H);

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.98(s, 1H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.74(s,2H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H);

(97)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61 (d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H), 9.34(s, 1H);

(98)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 6.60-6.61(d, 1H), 6.63-6.65(t, 1H), 6.96-6.98(t, 1H), 6.99-7.01 (d, 1H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H);

(99)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.46-5.48(d, 1H), 7.10-7.11(d, 1H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.82(s, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H);

(100)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(t, 1H), 7.59-7.61(d, 1H), 7.86-7.88(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.16-8.18(d, 1H), 8.49-8.51 (d, 1H);

(101)2-(4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 7.31(s, 1H), 7.43-7.45(1,1 H), 7.59-7.61(d, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.49-8.51 (d, 1H), 8.57-8.59(d, 1H), 11.53(s, 1H);

(102)(b)-2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 3.80(s, 1H), 4.73-4.77(t, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.72-7.74(t, 1H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H);

(103)(b)-2-(6-methoxypropyl)-1H-benzimidazol--[N(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 3.80(s, 1H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.50-6.52(d, 1H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.40(d, 1H), 7.43-7.45(1,1 H), 7.72-7.74(t, 1H), 7.89-7.90(d, 1H), 7.93-7,95(d, 1H);

(104)2-(6-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m, 1H), 3.65-3.68(t, 1H), 3.80(s, 1H), 4.73-4.77(t, 1H), 6.50-6.52(d, 1H), 7.29-7.30(d,2H), 7.38-7.39(d, 1H), 7.40-7.41 l(d,2H), 7.43-7.45(t, 1H), 7.89-7.91 (d, 1H), 7.72-7.74(t, 1H), 7.93-7.94(d, 1H);

(105)2-(6-methoxypropyl)-1H-benzimidazol-4-(N,N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(1,1 H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(106)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.80(s, 1H), 3.99-4.01(m, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(1,1 H), 7.89-7.91 (d, 1H),7.93-7.94(d, 1H);

(107)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.40(d, 1H), 7.43-7.45(1,1 H), 7.72-7.74(t, 1H), 7.89-7.91(d, 1H), 7,92-7,94(d,1H)

(108)2-(6-methoxypyridine)-dipyridyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.27(s,2H), 6.38-6.40(d, 1H), 6.50-6.52(d, 1H), 6.56-6.58(t, 1H), 6.75-6.76(d, 1H), 7.02-7.04(1,1 H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(1,1 H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(109)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (MSO, 400MHz) 6: 3.80(s, 1H), 6.35-6.37(d, 1H), 6.50-6.52(d, 1H), 6.93(s, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.54-7.56(d, 1H), 7.72-7.74(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H);

(110)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(1,1 H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.37(s,2H), 9.24-9.26(d, 1H), 13.00-13.03(d, 1H);

(111)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.61(s.1H), 8.63-8.65(d, 1H), 13.71-13.75(d, 1H);

(112)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m, 1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(1,1 H), 7.90-7.91 (d, 1H), 7.72-7.74(1,1 H). 7.93-7.94(d, 1H);

(113)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.34-8.35(d, 1H), 8.36(s, 1H), 8.40-8.42(d, 1H);

(114)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 6.93-6.95(t, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H),8.45-8.46(d,2H)

(115)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 6.62-6.64(t, 1H), 6.70-6.72(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.55-7.57(t, 1H), 7.72-7.74(1,1 H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H),8.07-8.09(d, 1H);

(116)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 245(s,3H), 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.12(s, 1H);

(117) 2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.82(s, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 8.33(s, 1H),

^1§^6?-^ilexibility)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 3.82(s,6H), 5.71(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H);

(119)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 5.98(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91 (d, 1H), 7.72-7.74(1,1 H), 7.93-7.94(d, 1H);

(120)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(1,1 H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 9.34(s, 1H);

(121)2-(6-methoxyphenyl)-1H-benzimidazol-4-(1H-about-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 6.60-6.61(d, 1H), 6.63-6.65(1,1 H), 6.96-6.98(t, 1H), 6.99-7.01 (d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H);

(122)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) 6: 3.80(s, 1H), 5.46-5.48(d, 1H), 6.50-6.52(d, 1H), 7.10-7.11(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.82(s, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H)

(123)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.86-7.88(d, 1H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H),8.16-8.18(d,1H)

(124)2-(6-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d, 1H), 7.43-7.45(1,1 H), 7.72-7.74(1,1 H), 7.89-7.91 (d, 1H), 7.93-7.94(d, 1H), 8.57-8.59(d, 1H),11.53(s,1H)

(125)(L)-dimethylaminopropyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 6.65-6.67(d, 1H), 6.86(s, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H), 8.32-8.35(d, 1H);

(126)(L)-2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1 - gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 3.17-3.18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.65-6.67(d, 1H), 6.86(s, 1H), 7.11-7.13(d,2H), 7.43-7.45(1,1 H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8.32-8.35(d, 1H);

(127)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 2.68(s,6H), 3.25-3.28(m, 1H), 3.65-3.68(t, 1H), 4.73-4.77(1,1 H), 6.65-6.67(d, 1H), 6.86(s, 1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H),

7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(128)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-^-^-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.68(s,6H), 3.10-3.15(t,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(129)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 265-2.66(m,1H), 2.68(s,6H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01 l(m,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(130)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(131)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.65-6.67(d,1H), 6.75-6.76(d,1H), 6.86(s,1H), 7.02-7.04(t,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(132)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.35-6.37(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(133)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(134)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(135)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.68(s,6H), 2.80-2.83(m,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(1,1 H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H);

(136)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(137)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.45-8.46(d,2H);

(138)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.62-6.64(1,1 H), 6.65-6.67(d,1H), 6.70-6.72(d,1H), 6.86(s,1H), 7.43-7.45(1,1 H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H),8.32-8.35(d,1H);

(139)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.32-8.35(d,1H);

(140)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)am ID

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.30(s,1H), 8.32-8.35(d,1H), 11.53(s,1H);

(141)2-(4-distillability)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 3.82(s,6H), 5.71(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(142)2-4-dimethylaminopropyl)-1H-bioimitator-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 5.98(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(143)2-4-dimethylaminopropyl)-1H-bioimitator-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2,68(s,6H), 6.65-6.67(d,1H), 6.86(s,1), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 9.34(s,1H);

(144)2-4-dimethylaminopropyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.60-6.61 l(d,1H), 6.63-6.64(1,1 H), 6.66-6.67(d,1H), 6.86(s,1H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H),8.32-8.35(d,1H);

(145)2-4-dimethylaminoethyl)-1H-buyingas(m-4^-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 5.46-5.48(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(146)2-(4-dimethylaminophenyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.32-8.35(d,1H);

(147)2-4-dimethylaminopropyl)-1H-benzimidazol-4-^-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(148)(Ü)-2-(23,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-(1-gidroksimetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(149)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-(1-gidroksimetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,9H), 4.73-4.77(1,1 H), 6.27(s,2H), 6.50-6.52(d,1H), 6.56-6.58(d,2H), 7.11-7.12(d,2H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(150)2-(23,4-trim�of oxyphenyl)-1H-benzimidazol-4-(N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(151)2-(23"4-trimethoxyphenyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m.4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(152)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,9H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(153)2-(23,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.10-7.11(d.1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(154)2-(23,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t, 1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H),7.93-7.94(d,1H);

(155)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.35-6.37(d,1H), 6.50-6.52(d,1H), 6.93(s,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(156)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13,00-13,03(d,1H)

(157)2-(2,3,4-trimethoxyphenyl)-1H-bioimitator-4-^-4'-pyrazoline

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H)

(158)2-(2,3,4-trimethoxyphenyl)-1H-elao-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H);

(159)2-(23,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H)

(160)2-(23,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.93-6.95(t,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(161)2-(23,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H),8.07-8.09(d,1H);

(162)2-(23,4-trimethoxyphenyl)-1H-bioimitator-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(163)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(164)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.82(s,6H), 3.83(s,9H), 5.71(s,1H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.3-7.94(d,1H);

(165)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 5.98(s,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.74(s,2H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(166)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(167)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.13-7.14(d,1H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H),7.93-7.94(d,1H);

(168)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-2-patacsil-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91 l(d,1H),7.92-7.94(d,1H)

(169)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(170)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(171)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20 (d,2H);

(172)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.88-6.90(d,1H), 7.11-7.13(d,2H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.90(d,1H),7.93-7.95(d,1H);

(173)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hudroxide)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(1,1 H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(174)2-(3-hydroxyl-4-methoxyphenyl)-1H - benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(175)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,3H), 3.99-4.01(m,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(176)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.12-7.15(d,2H), 7.21(s,1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(177)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.88-6.90(d,1H), 7.02-.04(t,1H), 7.21(s,1H), 7.53-7.55(d,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(178)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s.1H), 6.35-6.37(d,1H), 6.88-6.90(d,1H), 6.93(s,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.49-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(179)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(180)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(181)(2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-N'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.90-7.91 (d, 1 H), 7.93-7.94(d, 1 H);

(182)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(183) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 6.93-6.95(t,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(184)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-pyrazolyl)amide

1H NMR (DMSO, 400MHz) S: 3.83(s,3H), 5.35(s,1H) 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.51-7.52(d,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H),8.07-8.09(d,1H);

(185)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(186)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s.1H);

(187)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.79(s,6H), 3.83(s,3H), 5.35(s,1H), 5.71(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(188)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 5.98(s,1H), 6.88-6.90(d.1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(189)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(190)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H). 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.88-6.90(d,1H), 6.96-6.98(1,1 H), 6.99-7.01 l(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(191)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 5.46-5.48(d,1H), 6.88-6.90(d,1H), 7.10-7.11(d,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(192)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(193)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(1,1 H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(194)(L)-2-(2-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide (see Fig.4)

1H MNR(DMSO,400MHz) δ:3.57-3.61 (m, 1 H),3.66-3.70(m, I H),4.20-4.22(m, I H),5.08-5.11 ( q,1H),5.28-5.29(d,1H),6.29-6.30(d,1H), 7.28-7.32(t,1H), 7.57-7.61(m,1H), 7.67-7.73(m,4H), 8.02-8.06(m,3H), 8.57-8.59(m,1H), 8.78-8.80(m,1H), 10.47-10.49(d,1H), 13.62(s,1H);

(195)(L)-2-(2-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(1,1 H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.85-7.86(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.38-8.41 (d, 1 H), 8.59-8.60(d, 1 H);

(196)2-(2-pyridyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.36-7.38(t,1H), 7.40-7.41 l(d,2H), 7.43-7.45(1,1 H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(197)2-(2-pyridyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 00MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(198)2-(2-pyridyl)-1H-benzimidazol-4-(N-2-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01 (m,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H) , 8.38-8.41(d,1H),8.59-8.60(d,1H);

(199)2-(2-pyridyl)-1H-benzimidazol-4-(N-2'-benzimidazol)amide

1H NMR (DMSO, 400MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.85-7.86(t,1H), 7.89-7.91 (d.1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(200)2-(2-pyridyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); .

(201)2-(2-pyridyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.54-7.56(d,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H),8.59-8.60(d,1H);

(202)2-(2-pyridyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.24-9.26(d,1H),13.00-13.03(d,1H);

(203)2-(2-pyridyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 8.61(s,1H), 8.63-8.65(d,1H),13.71-13.75(d,1H);

(204)2-(2-pyridyl)-1H-benzimidazol-4-(N-(N'-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H),2.80-2.83(m,4H), 7.36-7.38(1,1 H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H),8.59-8.60(d,1H);

(205)2-(2-pyridyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(1,1 H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.38-8.41(d,1H), 8.43-8.45(d,1H),8.59-8.60(d,1H);

(206)2-(2-pyridyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.45-8.46(d,2H), 8.59-8.60(d,1H);

(207)2-(2-pyridyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 6.62-6.64(1,1 H), 6.70-6.72(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.86(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(208)2-(2-pyridyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(209)2-(2-pyridyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 11.53(s,1H);

(210)2-(2-pyridyl)-1H-benzimidazol-4-(N-2,4-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(211)2-(2-pyridyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.98(s,1H), 7.36-7;38(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.85-7.86(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(212)2-(2-pyridyl)-1H-benzo�midazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.85-7.86(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.34(s,1H);

(213)2-(2-pyridyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.85-7.86(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(214)2-(2-pyridyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(215)2-(2-pyridyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(1,1 H), 7.85-7.86(1,1 H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(216)2-(2-pyridyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.57-8.59(d,1H), 8.59-8.60(d,1H), 11.53(s,1H);

(217)(L)-2-(3-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO. 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(1,1 H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.42-8.44(d,1H), 8.70-8.72(d,1H),9.24(s,1H);

(218)(L)-2-(2-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d,1H)9.24(s,1H);

(219)2-(3-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d,1H),9.24(s,1H);

(220)2-(3-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(1,1 H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.41-8.43(d,1H), 8.45-8.46(d,2H), 8.70-8.72(d,1H), 9.24(s,1H);

(221)(L)-2-(4-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(222)(L)-2-(4-pyridyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(223)2-(4-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01 l(m,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(224)2-(4-pyridyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.45-8.46(d,2H), 8.75-8.77(d,2H);

(225)(L)-2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.64-7.67(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 8.17-8.20(d,2H), 9.34-9.37(d,1H);

(226)(L)-2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(227)2-(3-pyridazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(228)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(229)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(230)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2'-benzimidazol)amide

1H NMR (DMSO, 400MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(231)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H),7.61-7.63(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(232)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9,24-to 9.27(d,1H)

(233)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) 6: 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 9.34-9.37(d,1H), 13.00-13.03(d,1H);

(234)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.34-9.37(d,1H), 13.71-13.75(d,1H);

(235)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H) , 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(236)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.34-9.37(d,1H);

(237)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.45-8.46(d,2H), 9.34-9.37(d,1H);

(238)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(1,1 H), 7.55-7.57(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.11-8.13(d,1H),8.59-8.60(d,1H);

(239)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.12(s,1H), 9.34-9.37(d,1H);

(240)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91 l(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.33(s,1H), 9.34-9.37(d,1H), 11.53(s,1H);

(241)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(242)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11 l(d,1H), 9.34-9.37(d,1H);

(243)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(1,1 H), 7.61-7.63(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.32(s,1H), 9.34-9.37(d,1H);

(244)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(1,1 H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(245)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.82(s,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(246)2-(3-pyridazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.86-7.88(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.16-8.18(d,1H), 9.34-9.37(d,1H);

(247)2-(3-pyridazinyl)-N-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91 (d.1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.57-8.59(d,1H), 9.34-9.37(d,1H), 11.53(s,1H);

(248)(L)-2-(4-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(t,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.77-7.80(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d.2H), 9.30-9.32(d,1H), 9.46(s,1H);

(249)(L)-2-(4-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.90(d.1H), 7.93-7.95(d,1H), 9.30-9.32(d,1H), 9.46(s,1H);

(250)2-(4-pyridazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 9.30-9.32(d,1H), 9.46(s,1H);

(251)2-(4-pyridazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.30-9.32(d,1H), 9.46(s,1H);

(252)(L)-2-(2-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(1,1 H), 7.43-7.45(1,1 H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.76-8.79(d,2H), 9.34(s,1H);

(253)(L)-2-(2-pyridazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]am�d

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(254)2-(2-pyrazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(1,1 H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(255)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H). 9.34(s,1H);

(256)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(257)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(258)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(1,1 H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.911(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s, 1H)

(259)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(260)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45 (1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.76-8.79(d,2H), 9.24-9.26(d,1H), 9.34(s,1H), 13.00-13.03(d,1H);

(261)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 13.71-13.75(d,1H);

(262)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(263)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(264)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.76-8.79(d,2H), 9.34(s,1H);

(265)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(266)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(267)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(1,1 H), 7.89-7.911(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H);

(268)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(269)2(2-pyrazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(270)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 9.37(s,1H);

(271)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.43-7.45(t.1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(272)(2-(2-pyrazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(273)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(1,1 H), 7.86-7.88(d.1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(274)2-(2-pyrazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H);

(275)(L)-2-(2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(276)(L)-2-(2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.17(m,1H), 4.73-4.77(1,1 H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(277)2-(2-piperazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m.1H), 3.09-3.11(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H);

(278)2-(2-piperazinyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.13-3.15(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d.1H), 7.93-7.94(d,1H);

(279)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,4H), 2.62-2.63(m,2H), 2.65-2.66(m,2H), 2.69-2.70(m.2H), 2.72-2.74(m,2H), 2.77-2.80(m,1H), 2.84-2.86(m,1H), 3.02-3.05(m,1H), 3.09-3.11(m,1H), 3.99-4.01(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H);

(280)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(281)2-(2-piperazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H),7.93-7.94(d,1H);

(282)2-(2-piperazinyl)-1H-benim�Gasol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(1,1 H), 7.54-7.56(d,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(283)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(284)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(285)2-(2-piperazinyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 1.94-1.95(m,1H), 2.62-2.63(m,1H), 2.65-2.67(t,5H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.80-2.83(m,4H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(1,1 H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H);

(286)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m.1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(287)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(288)2 -(2-piperazinyl)-1 H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63 (1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H),8.07-8.09(d,1H);

(289)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.45(s,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(290)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7,43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(291)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyridinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.82(s,6H), 5.71(s,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(292)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H);7.93-7.94(d,1H);

(293)2-(2-piperazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(294)2-(2-piperazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.7-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.98(1,1 H), 6.99-7.01(d,1H). 7.43-7.45(t,1H), 7.89-7.91(d,1H),7.93-7.94(d,1H);

(295)2-(2-piperazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(1,1 H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(296)2-(2-piperazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.ll(m,1H), 4.14-4.17(m,1H), 7.43-7.45(1,1 H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(297)2-(2-piperazinyl)-1H-benzimidazol-4-(1H-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.ll(m,1H), 4.14-4.17(m,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(298)(L)-2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) 6: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71 l(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d, 1 H), 8.17-8.20(d,2H);

(299)(L)-2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

'YAMR (DMSO, 400MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71 l(t,1H), 2.72-2.74(1,1 H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.6-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H),7.93-7.95(d,1H);

(300)2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.06(t,6H), 1.91-1.93(m,2H), 2.40-2.43(m,4H), 2.59-2.60(d,1H), 2.62-2.63(m,1H), 2.64-2.65(t,1H), 2.66-2.67(m,1H), 2.68-2.70(t,2H), 2.72-2.73(m,1H), 2.74-2.75(t,1H), 2.76-2.78(t,1H), 2.77-2.80(m,1H), 2.88-2.90(d,1H), 3.02-3.05(m,1H), 3.99-4.01 l(m,1H), 4.14-4.16(t,1H), 7.43-7.45(t,1H), 7.89-7.911(d,1H), 7.93-7.94(d,1H);

(301)2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71 l(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 4.14-4.16(t,1H), 6.93-6.95(1,1 H), 7.43-7.45(1,1 H), 7.89-7.911(d,1H), 7.93-7.94(d.1H), 8.45-8.46(d,2H);

(302)(L)-2-(N-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3.18-3.22(t,4H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(303)(L)-2-(N-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3.18-3.22(t,4H), 3.25-3.28(m,1H), 3.50-3.52(m,1H). 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(1,1 H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(304)2-(N-piperazinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(305)2-(N-piperazinyl)-1H-benzimidazol-4-(N-N'-piperidin�yl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.10-3.15(t,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(306)2-(N-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) S: 1.91-1.93(m,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.78-2.82(m,5H), 3.02-3.05(m,1H), 3.17-3.22(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(307)2-(N-piperazinyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(308)2-(N-piperazinyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,l H), 7.43-7.45(t,1H), 7.89-7.91(d.1H),7.93-7.94(d,1H);

(309)2-(N-piperazinyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(310)2-(N-piperazinyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(311)2-(N-piperazinyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(312)2-(N-piperazinyl)-1H-benzimidazol-4-(N-(N'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,2H), 2.65-2.67(t,4H), 2.78-2.80(m,4H), 2.81-2.83(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.90-7.91 l(d,1H), 7.93-7.4(d,1H);

(313)2-(N-piperazinyl)-1H-bassinator-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(314)2-(N-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(315)2-(N-piperazinyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); :

(316)2-(N-piperazinyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.45(s,3H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(317)2-(N-piperazinyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s.1H);

(318)2-(N-piperazinyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(319)2-(N-piperazinyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(320)2-(N-piperazinyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.897.91 l(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(321)2-(N-piperazinyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H),7.93-7.94(d,1H);

(322)2-(N-piperazinyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(1,1 H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(323)2-(N-piperazinyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(324)2-(N-piperazinyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(325)(L)-2-ethyl-N'-piperazinyl)-1H-benzimidazol-4-[N(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), , 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H);

(326)(L)-2-(N-ethyl-N'-piperazinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(1,1 H), 7.89-7.90(d,1H),7.93-7.95(d,1H);

(327)2-(N-ethyl-N'-piperazinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1 H NMR (DMSO, 400MHz) δ: 1.02-1.05(t,3H), 1.91-1.93(m,2H), 2.38-2.41(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H),7.93-7.94(d,1H);

(328)2-(N-ethyl-N-piperazinyl)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.02-1.05(t,3H), 2.38-2.41 (m,2H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(329)(L)-2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H). 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(1,1 H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(330)(L)-2-(2-pyrrolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m.1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.95-6.97(d,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(331)2-(2-pyrrolyl)-1H-benzimidazol-4-N-(1-methyl-2-p-chlorophenylacetyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(332)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(333)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), .65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(334)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(335)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.27(s,2H), 6.38-6.39(d,1H), 6.40-6.42(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.95-6.97(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(336)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.35-6.37(d,1H), 6.40-6.42(d,1H), 6.93(s,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7,93-7,94 (d, 1H)

(337)2-(2-piroli)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(338)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(339)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t.4H), 2.80-2.83(m,4H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(340)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(341)2-(2-nHponHn)-1H-6eH3HMHAa3on-4-(N-2-pyrazinyl)amide

'HnMP(DMSO,400MHz)δ:6.15-6.18(t, 1 H),6.40-6.42(d. 1 H),6.93-6.95(t, 1 H), 6.98-7.01(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(342)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(343)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(344)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR(DMSO,400MHz)δ:6.15-6.18(t, 1 H),6.40-6.42(d, 1 H),6.95-6.97(d, 1 H),7.43-7.45(t, 1 H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(345)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR(DMSO,400MHz)δ:3.82(s,6H), 5.71(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(346)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.98(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(347)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t.1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(348)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.90-6.93(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(349)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR(DMSO,400MHz)δ:5.46-5.48(d,1H),6.15-6.18(t,1H),6.40-6.42(d,1H),6.95-6.97(d,1H),7.10-7.11(d,1H),7.43-7.45(t,1H),7.82(s,1H),7.89-7.91(d,1H),7.93-7.94(d,1H);

(350)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H),7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(351)2-(2-pyrrolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(352)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.99(s,2H),7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(353)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-R-a monophenyl hydroxyethyl)]amide

'HnMP(DMSO,400MHz)δ: 2.45(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(1,1 H), 6.27(s,2H), 6.56-6.58(d,2H), 6.99(s,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(354)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 2.45(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.99(s,2H), 7.29-7.30(d,2H), 7.40-7.41 l(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H),7.93-7.94(d,1H);

(355)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO. 400MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.45(s,3H), 3.10-3.15(t,4H), 6.99(s,2H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(356)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.45(s,3H), 2.62-2.63(m,1H). 2.65-2.66(m,1H), 2.69-2.7(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.99(s,2H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(357)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(358)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.99(s,2H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(359)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 6.99(s,2H), 7.43-7.45(1,1 H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(360)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazole yl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(361)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(362)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.95(m,1H), 2.45(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H);

(363)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(364)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyrimid�Neal)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.93-6.95(1,1 H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(365)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(366)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,6H), 6.99(s,2H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H),8.12(s,1H);

(367)2-(4-methyl-5-aminothiazolyl)-1H-metomidate-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d.1H), 8.33(s,1H), 11.53(s,1H);

(368)2-(4-methyl-5-aminothiazolyl)-1H-metomidate-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 3.82(s,6H), 5.71(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(369)2-(4-methyl-5-aminothiazolyl)-1H-metomidate-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 5.98(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(370)2-(4-methyl-5-aminothiazolyl)-1H-bulimias(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H),9.34(s,1H);

(371)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.97(t,1H), 6.99(s,2H), 7.02-7.05(d,1H), 7.43-7.45(1,1 H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(372)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

p> 1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 5.46-5.48(d,1H), 6.99(s,2H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H);

(373)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(1,1 H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(374)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(375)(L)-2-(2-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.64-7.65(d,2H), 7.76-7.77 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.17-8.20(d,2H), 8.44-8.46(d,1H);

(376)(L)-2-(2-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.39-7.40(d,1H), 7.43-7.45(1,1 H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.40-8.41 l(d,1H), 8.44-8.46(d,1H);

(377)2-(2-chinoline)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.35-7.37(d,1H), 7.40-7.41 l(d,2H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t.1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H),8.44-8.46(d,1H);

(378)2-(2-chinoline)-1H-benzimidazol-4-(N-N'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.5-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(379)2-(2-chinoline)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d.1H), 8.44-8.46(d,1H);

(380)2-(2-chinoline)-1H-benzimidazol-4-(N-2'-benzimidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(1,1 H), 7.78-7.79 (t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(381)2-(2-chinoline)-1H-benzimidazol-4-(N-o-Dapsone base)amide

1H NMR (DMSO, 400MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(1,1 H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(382)2-(2-chinoline)-1H-benzimidazol-4-(N-5-benzimidazolinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.60-7.62(t,1H), 7.78-7.79 (t.1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(383)2-(2-chinoline)-1H-benzimidazol-4-(N-4'-carbonamide-5'-imidazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.37(s,2H), 8.44-8.46(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(384)2-(2-chinoline)-1H-benzimidazol-4-(N-4'-pyrazolyl)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(1,1 H), 7.60-7.62(1,1 H), 7.78-7.79 (t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d1H), 8.44-8.46(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(385)2-(2-chinoline)-1H-benzies-4-(N-(N'-piperazinyl))amide

1H NMR (DMSO. 400MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(1,1 H),' 7.78-7.79 (t,1H), 7.90-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(386)2-(2-chinoline)-1H-benzimidazol-4-(N-2-pyrazinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(1,1 H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,l H), 8.06-8.07(d,1H), 8.34-8.35(d,1H), 8.36(s,1H). 8.40-8.42(d,1H), 8.44-8.46(d,1H);

(387)2-(2-chinoline)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.40-8.43(d,1H), 8.45-8.46(d,2H);

(388)2-(2-chinoline)-1H-benzimidazol-4-(N-2-pyridyl)amide

1H NMR (DMSO, 400MHz) δ: 6.62-6.64(1.1 H), 6.70-6.72(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.04-8.05(d,1H), 8.07-8.09(d,1H), 8.44-8.46(d,1H);

(389)2-(2-chinoline)-1H-benzimidazol-4-(N-4-methyl-5-thiazolyl)amide

1H NMR (DMSO, 400MHz) δ: 2.45(s,3H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(1,1 H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.12(s,1H), 8.44-8.46(d,1H);

(390)2-(2-chinoline)-1H-benzimidazol-4-(N-2,4-dihydroxy-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.33(s,1H), 8.44-8.46(d,1H), 11.53(s,1H);

(391)2-(2-chinoline)-1H-benzimidazol-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) �: 3.82(s,6H), 5.71(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d, 1H);

(392)2-(2-chinoline)-1H-benzimidazol-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.98(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.74(s,2H), 7.78-7.79 (t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d, 1 H), 8.44-8.46(d, 1 H);

(393)2-(2-chinoline)-1H-benzimidazol-4-(N-4,6-dichloro-5-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(1,1 H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 9.34(s,1H);

(394)2-(2-chinoline)-1H-benzimidazol-4-(N-o-fluorophenyl)amide

1H NMR (DMSO, 400MHz) δ: 6.60-6.61 l(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01 l(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(395)2-(2-chinoline)-1H-benzimidazol-4-(N-2-hydroxyl-4-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.82(s,1H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(396)2-(2-chinoline)-1H-benzimidazol-4-(N-6-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.16-8.18(d,1H), 8.44-8.46(d,1H);

(397)2-(2-chinoline)-1H-benzimidazol-4-(N-6-hydroxyl-2-purinol)amide

1H NMR (DMSO, 400MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H),11.53(s,1H);

(398)(L)-2-(3-chinoline)-1H-benzimidazol-4-[N-(1-hydroxy�ethyl-2-p-nitrophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.59-7.60(t,1H), 7.62-7.65(d,2H), 7.77-7.79(1,1 H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.17-8.20(d,2H), 8.22(s,1H). 8.57(s,1H);

(399)(L)-2-(3-chinoline)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.60-7.62(1,1 H), 7.77-7.79(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H);

(400)2-(3-chinoline)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.91-1.93(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01 (m,1H), 7.43-7.45(t,1H), 7.60-7.62(1,1 H), 7.89-7.91 l(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H);

(401)2-(3-chinoline)-1H-benzimidazol-4-(N-2-pyrimidinyl)amide

1H NMR (DMSO, 400MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(1,1 H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.45-8.46(d,2H),8.57(s,1H);

(402)(L)-2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-nitrophenyl hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 8.17-8.20(d,2H);

(403)(L)-2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-gidroximetil-2-p-Dapsone base hydroxyethyl)] amide

1H NMR (DMSO, 400MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 150-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81 l(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d, 1 H), 7.93-7.95(d, 1 H);

(404)2-(2-piperidinyl)-1H-benzimidazol-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide

1H NMR (DMSO, 400MHz) δ: 1.12-1.15(d,3H), 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(405)2-(2-piperidinyl)-1H-benzimidazol-4-(R|?-1H'-piperidinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.51(m,1H), 1.53-1.55(m,4H), 1.55-1.57(m,1H), 1.59-1.63(m,2H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.10-3.15(t,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H),7.93-7.94(d,1H);

(406)2-(2-piperidinyl)-1H-benzimidazol-4-(N-2-piperazinyl)amide

1H NMR (DMSO, 400MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), L50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.87-1.88(m,1H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.73(m