Cosmetic composition, containing particels of silicon dioxide aerogel and siliconee oils

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely represents composition, which contains mixture of particles of hydrophobic silicon dioxide aerogel, which have specific area of surface per weight unit (Sw) in range from 500 to 1500 m2/g and size, expressed in form of volume mean diameter (D[0.5]), in range from 1 to 1500 mcm, and at least one first linear silicone oil, which has viscosity higher than 50 mm2/s, and at least second and third linear silicone oils, and each of them has viscosity lower than or equal 50 mm2/s.

EFFECT: mixture of particles of silicon dioxide aerogel and linear oils provides possibility of obtaining compositions, which provide comfort and smoothness of skin after application and have dullness and "soft focus"-adding properties.

23 cl, 8 ex

 

The invention relates to a cosmetic composition for keratin materials, in particular the skin and lips, hair and nails. The invention also relates to a cosmetic method of treatment of keratin materials using said composition.

In the field of cosmetic compositions for skin care known practice of using "magmatogennyh" inorganic or organic fillers which absorb sebum and sweat, to give a Matt appearance to the skin and/or optical smoothing the microrelief and camouflage skin imperfections.

However, the use of these fillers are generally accompanied by a feeling of dryness, roughness and lack of comfort, which is unacceptable for the user.

Silicone elastomers are also widely used as imparting a matte funds because they provide the possibility of obtaining a smooth skin, but they must be used at relatively high levels for the effect of giving a Matt finish that creates a restriction in the choice of texture and increases the cost of the composition.

However, there remains a need for cosmetic compositions that have the effect of giving a Matt finish and/or which provide the possibility of masking blemishes, have good cosmetic properties, in particular, provide padcast� skin after application and create less restriction from the point of view of costs.

The applicant has discovered that this need can be satisfied by a combination of the composition of particles of a hydrophobic aerogel of silica and a mixture of silicone oils.

More specifically, one object of the present invention is a cosmetic composition containing a mixture:

- particles of hydrophobic silicon dioxide aerogel having a specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, and

- at least one first linear silicone oil having a viscosity of more than 50 mm2/sec, and at least the second and third linear silicone oils, and each of them has a viscosity of less than or equal to 50 mm2/S.

Another object of the present invention is a cosmetic composition containing a mixture:

- particles of hydrophobic silicon dioxide aerogel having a specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, and

- at least one first linear silicone oil having a viscosity of less than 10 mm2/sec, and at least one second linear silicone oil having a viscosity of more� than or equal to 10 mm 2/S.

A mixture of particles of silicon dioxide aerogel and linear silicone oils enables the preparation of compositions, which provide comfort and smoothness of the skin after application, are giving trouble and "magliacane properties. It can be used for full or partial replacement of the silicone elastomers that are typically used to obtain these properties.

A mixture of particles of silicon dioxide aerogel and linear silicone oils mainly presented in the form of a gel which does not flow under the action of its own weight.

Another object of the present invention is a mixture:

- particles of hydrophobic silicon dioxide aerogel having a specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, and

- at least one first linear silicone oil having a viscosity of more than 50 mm2/sec, and at least the second and third linear silicone oil having a viscosity of less than or equal to 50 mm2/S.

Another object of the present invention is a mixture:

- particles of hydrophobic silicon dioxide aerogel having a specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, and

- at least one first linear silicone oil having a viscosity of less than 10 mm2/sec, and at least one second linear silicone oil having a viscosity of more than or equal to 10 mm2/S.

Another object of the present invention is a cosmetic method of treatment and/or caring for keratin materials, comprising the step of applying the composition defined above for these materials.

In the following description, the expression "at least one" is equivalent to the expression "one or more", unless otherwise stated, the range of values included in this range.

Hydrophobic aerogels of silica

Aerogels dioxide flint are porous materials obtained by the substitution (by drying) the liquid component of silica gel with air.

They are generally synthesized via a Sol-gel method in a liquid medium and then dried, usually by extraction with a supercritical fluid, and is most commonly used supercritical CO2. This type of drying provides the opportunity to avoid wrinkling of the pores and of the material. The Sol-gel method and different methods of drying are described in detail in the publication Brinker CJ., and G. W. Scherer, Sol-Gel Science: New York: Academic Press, 1990.

Particles of hydrophobic silicon dioxide aerogel, used�by the present invention, have a specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g, preferably from 600 to 1200 m2/g and better still from 600 to 800 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, better still from 1 to 1000 μm, preferably from 1 to 100 μm, in particular from 1 to 30 μm, preferably from 5 to 25 μm, better still from 5 to 20 μm and even better from 5 to 15 microns.

In accordance with one variant of implementation of the particles of the hydrophobic aerogel of silica used in the present invention have a size expressed in average volume diameter (D[0,5]), in the range of 1 to 30 μm, preferably from 1 to 25 μm, better still from 5 to 20 μm and even better from 5 to 15 microns.

Specific surface area per unit weight may be measured by the method of nitrogen absorption BET (brunauer-Emmett-teller described in the Journal of the American Chemical Society, vol. 60, page 309, February 1938, and corresponding to international standard ISO 5794/1 (Appendix D). Specific surface area, a certain way BET, corresponds to the total specific surface area of the considered particles.

The particle sizes of the silicon dioxide aerogel can be measured by static light scattering using a commercially available particle size analyzer, such as the instrument MasterSizer 2000, manufactured by company�th Malvern. Data is processed on the basis of scattering theory may. This theory, which is exact for isotropic particles, provides the possibility of determining in the case of non-spherical particles "effective" particle diameter. This theory, in particular described in the publication by Van de Hulst, H. C., "Light Scattering by Small Particles," Chapters 9 and 10, Wiley, New York, 1957.

In accordance with one preferred variant implementation of the particles of the hydrophobic aerogel of silica used in the present invention have a specific surface area per unit mass (SM) in the range from 600 to 800 m2/g and a size expressed in average volume diameter (D[0,5]), in the range of 5 to 20 μm, better still from 5 to 15 microns.

Particles of silicon dioxide aerogel used in the present invention, may advantageously have a density after compaction (tap containing the aerogel capacity on a hard surface) in the range from 0.04 g/cm3to 0.10 g/cm3and preferably from 0.05 g/cm3to 0.08 g/cm3.

In the context of the present invention, this density is known as the density after compaction, can be evaluated according to the following Protocol:

40 g of powder are poured into a measuring cylinder, then the measuring cylinder is placed on the device Stav 2003, manufactured by Stampf Volumeter, and then the measuring cylinder is subjected to a series of 2500 days�Vij tapping containing powder capacity on a hard surface (this operation is repeated until while the difference in volume between two consecutive tests is less than than 2%); then the final volume Vf of the compacted powder is measured directly with a graduated cylinder. The density after compaction is determined by the ratio m/Vf, in this case, 40/Vf (Vf is expressed in cm3and m in g).

In accordance with one variant of implementation of the particles of the hydrophobic aerogel of silica used in the present invention have a specific surface area per unit volume SVin the range of 5 to 60 m2/cm3preferably from 10 to 50 m2/cm3and better still from 15 to 40 m2/cm3.

Specific surface area per unit volume is represented by the relation: SV=SM×p, where p denotes the density after compaction, expressed in g/cm3and SMdenotes the specific surface area per unit mass, expressed in m2/g, as defined above.

Preferably, the particles of hydrophobic silicon dioxide aerogel in accordance with the invention have the capacity of oil absorption, measured at a dew point in the range from 5 to 18 ml/g, preferably from 6 to 15 ml/g and better still from 8 to 12 ml/g of particles.

Absorption capacity, measured at the dew point, denoted as Wp, corresponds to the quantity of oil which must be added to 100 g of the particles to obtain a uniform pass�s.

It is measured according to the method of dew point or method of determining capture oil powder described in standard NF T 30-022. It corresponds to the amount of oil absorbed in the available surface of the powder and/or absorbed by the powder, the measurement of dew point as described below.

Some number, m=2 g of powder is placed on a glass slide and then added dropwise oil (isononyl isoneof) using the spatula, and the addition of oil is continued until the formation of conglomerates of oil and powder. Since then, the oil is added one drop at a time and the mixture is then abrade the powder with a spatula. The addition of oil is stopped, when you get a tight, soft paste. This paste must be able to be distributed on a glass plate without cracking or flaking. Then mark the volume Vs (expressed in ml).

The capture of the oil corresponds to the ratio Vs/m.

The aerogels used according to the present invention, are hydrophobic aerogels of silica, preferably silyl silicon dioxide (name according to INCI (International Nomenclature of Cosmetic Ingredients) silicate silicon dioxide).

The term "hydrophobic silica" means any silica whose surface is treated similitudine agents, for example halogenuros�prisoners who had been silanes, such as alkylchloro silane, siloxanes, in particular dimethylsiloxanes, such as hexamethyldisiloxane, or salasanasi to functionalitywith OH group silyl groups Si-Rn, for example trimethylsilyl groups.

As to obtain particles of hydrophobic silicon dioxide aerogel, which were subjected to surface modification by sellerbuyer, you can refer to U.S. patent No. 7470725.

In particular the use of the particles of hydrophobic silicon dioxide aerogel, which were subjected to surface modification by trimethylsilyl groups.

As the hydrophobic aerogels of silica that can be used in the invention include the aerogel sold under the name VM-2260 (INCI name: silicate silicon dioxide), by the company Dow Corning, the particles of which have an average size of approximately 1000 microns and a specific surface area per unit weight in the range from 600 to 800 m2/g.

You can also specify the aerogels sold by the company Cabot under the references AEROGEL TLD 201, AEROGEL OGD 201, AEROGEL TLD 203, ENOVA® AEROGEL MT 1100, ENOVA AEROGEL MT 1200.

More specifically, can be used the aerogel sold under the name VM-2270 (INCI name: silicate silicon dioxide), by the company Dow Corning, the particles of which have an average size in the range of 5 to 15 μm and a specific surface area per unit weight in the range from 600 d� 800 m 2/g.

Particles of hydrophobic silicon dioxide aerogel may be present in an amount of from 0.5 to 30 wt.%, preferably from 1 to 20 wt.%, better from 2 to 15 wt.%, preferably 5 to 10 wt.%, better still from 6 to 8 wt.%, mixture of linear silicone oils and aerogels of silica) in accordance with the invention.

Particles of hydrophobic silicon dioxide aerogel may be present in the composition in accordance with the invention in amounts in the range from 0.05 to 15 wt.%, preferably from 0.1 to 10 wt.%, better still from 0.5 to 5 wt%. and preferably from 0.5 to 2% wt., relative to the total weight of the composition.

Silicone oil

The composition in accordance with the invention comprises at least a first linear silicone oil having a viscosity of more than 50 mm2/s, preferably more than or equal to 100 mm2/s, even better more than or equal to 200 mm2/s, even better more than or equal to 300 mm2/s, and which may reach 500 mm2/S.

It also contains at least second and third linear silicone oil having a viscosity of less than or equal to 50 mm2/s, preferably less than or equal to 30 mm2/s, better still less than or equal to 20 mm2/s, better still less than or equal to 15 mm2/s, and which can be more than 1 mm2/S.

The viscosity of silikonowe� oil can be measured according to ASTM D-445. The term "oil" means a fatty substance which is liquid at room temperature (25°C).

The term "silicone oil" means an oil containing at least one atom of silicon, in particular containing the group Si-O.

The linear silicone oils are preferably polyorganosiloxanes containing structural units of alkylsilane, and the alkyl groups preferably contain from 1 to 6 carbon atoms and preferably are unsubstituted.

In particular, the linear silicone oils are selected from polydimethylsiloxane (INCI name: Dimethicone), preferably of formula:

in which x denotes an integer chosen so that it had a liquid connection.

In accordance with one variant of implementation of the first linear silicone oil is present in the mixture of linear silicone oils in an amount less than or equal to 20% of the mass. relative to the total weight of the mixture of linear silicone oils (first, second and third linear silicone oils), preferably less than or equal to 10 wt.%, better still less than or equal to 5% of the mass. It can represent from 0.5 to 20 wt.%, even better from 1 to 15 wt.%, even better from 1 to 10 wt.%, and preferably from 1 to 5 wt.%, relative to the total weight of the mixture of linear silicone oils.

The expression"mixture of linear silicone oils" refers to the designation of the first mixture, the second and third linear silicone oils.

In accordance with one variant of implementation of each of the second and third linear silicone oil is present in the mixture of linear silicone oils in an amount greater than or equal to 40% of the mass. relative to the total weight of the mixture of linear silicone oils, preferably more than or equal to 45 wt%. Each of them can represent 40 to 50% wt., preferably from 45 to 50 wt.%, the total weight of the linear silicone oils.

In accordance with one variant of implementation of the composition contains:

- at least one first linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 100 to 400 mm2/s, preferably from 200 to 300 mm2/s, in particular 350 mm2/s

at least one second linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 1 to 7 mm2/s, preferably from 2 to 6 mm2/s, in particular 5 mm2/s

- at least one third linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 8 to 20 mm2/s, preferably from 8 to 15 mm2/s, in particular 10 mm2/S.

In accordance with one variant of implementation of the composition contains:

- at least one per�first linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 100 to 400 mm2/s, preferably from 200 to 300 mm2/s, in particular 350 mm2/s, in quantities less than or equal to 20 wt.%, preferably less than or equal to 10 wt.%, the total weight of the linear silicone oils,

at least one second linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 1 to 7 mm2/s, preferably from 2 to 6 mm2/s, in particular 5 mm2/sec, in an amount greater than or equal to 40 wt.%, preferably greater than or equal to 45 wt.%, the total weight of the linear silicone oils,

- at least one third linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 8 to 20 mm2/s, preferably from 8 to 15 mm2/s, in particular 10 mm2/sec, in an amount greater than or equal to 40 wt.%, preferably greater than or equal to 45 wt.%, the total weight of the linear silicone oils.

In accordance with one variant of implementation of the composition contains:

- at least one first linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 100 to 400 mm2/s, preferably from 200 to 300 mm2/s, in particular 350 mm2/sec, in an amount in the range�area from 0.5 to 15 wt.%, preferably from 1 to 10 wt.%, even better from 1 to 5 wt.%, the total weight of the linear silicone oils,

at least one second linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 1 to 7 mm2/s, preferably from 2 to 6 mm2/s, in particular 5 mm2/sec, in an amount in the range from 40 to 50 wt.%, preferably from 45 to 50 wt.%, better still from 45 to,5% wt., the total weight of the linear silicone oils,

- at least one third linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 8 to 20 mm2/s, preferably from 8 to 15 mm2/s, in particular 10 mm2/sec, in an amount in the range from 40 to 55 wt.%, preferably from 42 to 52 wt.%, better still from 45 to 50 wt.%, the total weight of the linear silicone oils.

As linear silicone oils that may be used in compositions in accordance with the invention, it is possible to specify, for example, PDMS (polydimethylsiloxane) DC 200 Fluid 5 cSt, 10 cSt and 350 cSt sold by the company Dow Corning, or linear silicone oil sold by the company Wacker, under the name Wacker Belsil DM 10.

In accordance with one variant of the invention, the composition in accordance with the invention contains at least one first linear silicone oil, ima�ing a viscosity of less than 10 mm 2/s, preferably less than or equal to 7 mm2/sec, and more preferably from 3 to 7 mm2/S.

It also contains at least one second linear silicone oil having a viscosity of more than or equal to 10 mm2/sec, preferably from 10 to 100 mm2/sec, preferably from 10 to 50 mm2/sec, and more preferably from 10 to 30 mm2/S.

Under this option, the relative content of each of these oils is preferably such that one of the two oils is contained in the amount of at least 1.5 greater than another.

Linear silicone oil may represent from 80 to 99 wt.%, preferably from 85 to 99 wt%. and better still from 90 to 95 wt.%, total weight of the mixture (linear silicone oils and aerogels of silica).

The composition in accordance with the invention may contain a mixture of silicone oils and particles of silicon dioxide aerogel) in an amount in the range from 0.1 to 90 wt.%, preferably from 1 to 80 wt.%, better still from 2 to 30 wt%. and even better from 2 to 20 wt.%, relative to the total weight of the composition.

The composition in accordance with the invention may be aqueous or anhydrous.

The composition in accordance with the invention may be in any galenical form normally used for topical application, and, in particular, in the form of a dispersion type water g�La or lotion, emulsions of liquid or semi-liquid consistency of the type of milk, obtained by dispersion of a fatty phase in an aqueous phase (O/W) or conversely (W/O), or suspensions or emulsions of soft, semi-solid or solid consistency of the type of cream or gel, or alternatively multiple emulsions (W/O/W or O/W/O), microemulsions, dispersions in bubble media ionic and/or nonionic type or dispersions of the wax/water phase. It can also be represented in the form of bars, obtained by hot molding or extruded powders.

These compositions have, in accordance with conventional methods.

In accordance with one variant of the invention the composition is provided in the form of an emulsion O/W or water gel.

The composition of the invention can be used in any cosmetic or dermatological use, for example, in cosmetics for skin care, hair, hairy scalp, eyelashes, eyebrows, nails or mucous membranes (lips), for example, as protective, treatment or care products for the face, hands or body as the cleansing products skin (face or body), as the cosmetic products (e.g. foundations) or as products of care of hair.

Compositions in accordance with the invention may contain in addition to linear silicone oils, mixtures of particles of aerogel dio�sid silicon and linear silicone oils, in at least one "extra" oil.

As oils that can be used in the compositions according to the invention, examples that may be mentioned include:

- oil hydrocarbon-based animal origin, such as perhydrosqualene (or squalane);

- oil hydrocarbon-based plant origin such as liquid triglycerides of fatty acids containing from 4 to 10 carbon atoms, such as triglycerides geptanoevoy or octanoic acid, or alternatively, for example, sunflower oil, maize oil, soybean oil, marrow oil, grape seed oil, sesame seed, hazelnut oil, apricot oil, macadamia oil, oil karanxha, coriander oil, castor oil, avocado oil, triglycerides of Caprylic/capric acids, for example, oils sold by the company Stearineries Dubois or oils sold under the names Miglyol 810, 812 and 818 by the company Dynamit Nobel, jojoba oil, oil oil wood and liquid fraction of the oil tree;

- synthetic esters and ethers in particular of fatty acids or fatty alcohols, such as oils of formula R1COOR2and R1OR2in which R1represents a fatty acid residue containing from 8 to 29 carbon atoms, and R2represents a branched or unbranched chain on the basis of the hydrocarbon containing from 3 to 30 carbon atoms, �of primer, purcellin oil, isononyl isononanoate, the isopropyl myristate, 2-ethylhexyl palmitate (or ektralite), 2-octyldodecyl stearate, 2-octyldodecyl Erekat Il isostearyl of isostearate; hydroxylated esters, for example, isostearyl lactate, octyl hydroxystearate, octyldodecyl hydroxystearate, diisostearate malate, triazolyl citrate, and heptanoates, octanoate and decanoate fatty alcohol; PoE-oil complex, for example, propylene glycol dioctanoyl, neopentylglycol diheptanoate and dietilenglikoluretan; esters, pentaerythritol, for example, pentaerythrol tetraisostearate and lipophilic derivatives of amino acids such as the isopropyl lauroyl of sarcosinate (INCI name: Isopropyl Lauroyl of Sarcosinate) sold under the name Eldew SL 205 by the company Ajinomoto;

- linear or branched hydrocarbons of mineral or synthetic origin, such as mineral oil (a mixture of oils, hydrocarbon-based, derived from petroleum; INCI name: Mineral oil), volatile or nonvolatile liquid paraffins and their derivatives, petroleum jelly, polydecene, isohexadecane, isododecane, hydrogenated isoparaffin, for example, hydrogenated polyisobutene, such as oil, Parleam® sold by the company NOF Corporation (INCI name: Hydrogenated Polyisobutene);

fatty alcohols containing �t 8 to 26 carbon atoms, for example cetyl alcohol, stearyl alcohol and their mixture (cetylstearyl alcohol), octyldodecanol, 2-butyloctyl, 2-hexyldecanol, 2-underinternational or alerby alcohol;

- fluorinated oils partially hydrocarbon and/or silicone, for example oil, is described in the Japan patent JP-A-2-295 912;

- cyclic volatile silicone oils, such as cyclopolymerization (cyclomethicone), such as Cyclopentasiloxane and celexacelexa;

- polydimethylsiloxane containing phenyl groups, which are hanging, or on the end of a silicone chain, these groups contain from 2 to 24 carbon atoms; phenylsilane, for example, penultimately, penultimately, , diphenylmethane, divinyltetramethyldisiloxane and 2-phenylethyltrifluoroborate and polymethylphenylsiloxane;

- mixtures thereof.

Other fatty substances that may be present in the oily phase are, for example, fatty acids containing from 8 to 30 carbon atoms, for example stearic acid, Euroway acid or palmitic acid, resins such as silicone gums (dimethiconol); silicone resins such as trifluoromethyl(C1-4)alkyldimethyl and cryptosporidiosis; pastes, such as petrolatum; waxes such as microcrystalline waxes, �arpinovia waxes, lignite waxes, ceresin, ozokerite, Montan wax, beeswax, lanolin and its derivatives, candlelike wax, wax ouricarry, Carnauba wax, Japan wax, cocoa butter, palm oil in the form of a paste at 20°C, wax, cork fiber wax, sugar cane, hydrogenated oils that are solid at 25°C., fatty esters and glycerides that are solid at 25°C, polyethylene waxes, waxes obtained by Fischer-Tropsch synthesis, silicone waxes; and mixtures of these fatty substances.

In accordance with one variant of implementation of the arrangement in accordance with the invention contains less than 2% of the mass. and preferably less than 1 wt%. solids in the form of silicone elastomers, and even better does not contain silicone elastomers or elastomeric organopolysiloxanes. The term "elastomer" means a deformable, flexible solid material having viscoelasticity properties and, in particular, the consistency of a sponge or a soft sphere. Its modulus of elasticity is such that this material withstands deformation and has limited extensibility and compressibility. This material is able to recover its original shape after stretching. This elastomer is formed from polymer chains with high molecular weight, the mobility of which is limited by a uniform network of crosslinking points.

The elastomeric organosiloxane in General, partially or completely cross stitched and can be presented in the form of particles.

Such elastomers are, for example, products sold under the name KSG by companies Shin-Etsu, under the name of Trefil by the company Dow Corning or under the name Grancel by the company Grant Industries.

The composition in accordance with the invention can contain an aqueous phase, the amount of which may be in the range of, for example, from 30 to 98 wt.%, preferably from 40 to 98 wt.%, better still from 50 to 98 wt%. and even better from 55 to 98 wt.%, relative to the total weight of the composition.

Usually, the aqueous phase may contain, besides water, one or more water soluble solvent selected from polyols (or polyhydric alcohols) and water-soluble lower alcohols and mixtures thereof. The term "lower alcohol" means an alcohol containing from 1 to 8 and preferably from 1 to 6 carbon atoms. Examples of lower alcohols that may be mentioned include ethanol, isopropanol and butanol, and mixtures thereof.

Examples of polyols that may be mentioned include glycerol, glycols, such as propylene glycol or butyleneglycol; sorbitol; sugars such as glucose, fructose, maltose, lactose and sucrose, and mixtures thereof.

The amount of water-soluble solvents (polyols and lower alcohols) may be in the range of, for example, �t 0.5 to 30 wt.%, preferably from 0.5 to 20 wt.%, and even better from 1 to 15 wt.%, relative to the total weight of the composition.

Adjuvants

In a known manner, the composition according to the invention may also contain adjuvants commonly used in cosmetics and/or dermatology, such as active agents, preserving agents, antioxidants, complexing agents, pH modifiers (acidic or basic), fragrances, fillers, microbicides, odor absorbers, coloring agents (pigments and dyes), film forming polymers, emulsifiers, such as esters of fatty acids of polyethylene glycol, esters of fatty acids and glycerol esters of fatty acids sorbitan that are not necessarily polyoxyethylenated, polyoxyethylenated fatty alcohols and complex or simple esters of fatty acids sugars, such as sucrose or glucose; thickeners and/or gelling agents, in particular polyacrylamides, acrylic homopolymers and copolymers, and homopolymers and copolymers acrylamidophenylboronic acid and lipid vesicles. The amounts of these various adjuvants are those commonly used in the field under consideration, for example, from 0.01% to 20% of the total weight of the composition. Depending on their nature, these adjuvants may be introduced into the fatty phase, into the aqueous phase� and/or into lipid vesicles.

Needless to say that the person skilled in the art will be careful to choose this or these optional(s) extra(s) connection(s) and/or their amount so that the envisaged addition had no or essentially no adverse effect on imparting a matte/"magliacane properties of the composition in accordance with the invention.

Yet certain other indications in the patent application number is expressed on the basis of the mass relative to the total weight of the composition.

The following examples aim to illustrate the compositions and methods according to the present invention, but in no way constitute a limitation on the scope of the invention. All parts and percentages in the examples presented on the basis of mass, and until otherwise stated, all measurements were obtained approximately at 25°C.

Examples

Examples 1-5

Were obtained 5 compositions containing 7% of the particles of the hydrophobic aerogel of silica (product VM-2270 manufactured by Dow Corning), and 93% of the following mixtures of linear silicone oils.

Example 1 (invention)Example 2 (invention)Example 3 (comparative)Example 4 (Wed�nitely) Example 5 (comparative)
Dimethicone 350 cSt3,22100--
Dimethicone 10 cSt45,749-100-
Dimethicone 5 cSt51,149--100
Macroscopic appearanceGel that does not flowGel that does not flowHeterogeneous sampleGel that flowsGel that flows
Appearance after application to the skinMattMattNot evaluatedBrilliantBrilliant

Compositions were obtained by depositing particles of silicon dioxide aerogel under gentle stirring with a spatula.

These compositing�tion was evaluated visually by three of the individual, which then struck every note on the back of the hand and noted their matte/gloss properties, compared with untreated skin.

Only the compositions containing the mixtures from examples 1 and 2 in accordance with the invention, were presented in the form of a gel that does not leak, and which when applied to the skin are characterized by matt (matt), soft-focus the deposition.

Example 6: Cream for greasy skin

PhaseThe INCI name
AWATERHow much you want to 100
GLYCERIN5,00
DISODIUM EDTA0,05
Propylene GLYCOL6,60
BCAPRIGLIONE0,15
ISOHEXANE3,50
POLYSORBATE 80 (TWEEN 80-LQ-(WL), manufactured by Croda)1,00
DIMETHICONE (and) CETETH-10 (and) LAURETH-4 (DOW CORNING 7-3099 EMULSION DIMETIKONA HIP1,50
DIMETHICONE 350 cSt0,3
DIMETHICONE 10 cStThe 4.25
DIMETHICONE 5 cSt4,76
CISOHEXADECANE2,00
CARBOMER (CARBOPOL 981, manufactured by Lubrizl)0,15
DSODIUM HYDROXIDE0,06
WATER0,54
POLYACRYLOYLDIMETHYL AMMONIUM (Hostacerin AMPS, manufactured by Clariant)1,80
ENYLON-12 (ORGASOL 2002 EXD NAT COS, manufactured by Arkema)0,50
Ethanol 5,00
GParticles of hydrophobic silicon dioxide aerogel VM-2270 manufactured by Dow Corning)0,7

Procedure:

- heat phase B to about 70°C

- heat phase A to about 70°C

- obtain the emulsion by incorporating phase A into phase B

- at 40-45°C, add the remaining phases and continue stirring until cool.

Example 7: Moisturizer

B3
PhaseThe INCI name
AWATERHow much you want to 100
BOULENGERI5,00
GLYCERIN5,00
TETRANITRO EDTA0,20
PHENOXYETHANOL0,70
BGLICERINSTEARAT (and) PEG-100 STEARATE (ARLACEL 165-FL manufactured by Croda)2,00
Cetyl ALCOHOL0,50
METHYLPARABEN0,25
PEG-20 STEARATE 9MYRJ S20-PA-(WL), manufactured by Croda)0,80
STEARYL ALCOHOL0,50
STEARIC ACID3,00
CAPILLARISATION ACID (MEXORYL SAB manufactured by the company Chimex)0,05
POLYACRYLOYLDIMETHYL AMMONIUM (Hostacerin AMPS, manufactured by Clariant)1,60
DIMETHICONE 350 cSt0,15
DIMETHICONE 10 cStOf 3.64
DIMETHICONE 5 cStOf 3.64
B2TRIETHANOLAMINE0,30
Particles of hydrophobic silicon dioxide aerogel VM-2270 manufactured by Dow Corning)0,56

Procedure:

- heat phase B to about 75°C

- heat phase A to about 75°C

- obtain the emulsion by incorporating phase A into phase B

- at 40-45°C, add the remaining phases and continue stirring until cool.

The creams of examples 6 and 7 after application provide comfort and softness and provide an opportunity to obtain a good effect, giving the skin a matte appearance.

Example 8

Received the following mixture:

Mixture1 (invention)2 (comparative)3 (invention)4 (comparative)
Polydimethylsiloxane 350 cStTo 1.86---
Polydimethylsiloxane 10 cStOver 45.59323,25-
Polydimethylsiloxane 5 cStOver 45.5 -69,7593
The aerogel dioxide flint7777

By visual observation of the deposits obtained on the brush, it was found that a mixture of 1 and 3 provide the possibility of giving a Matt appearance to the skin and smoothing the skin's surface. Therefore, there is a clear effect of the correction of skin defects, which is not possible using the comparative mixtures 2 and 4.

1. Cosmetic composition containing a mixture:
- particles of hydrophobic silicon dioxide aerogel having a specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, and
- at least one first linear silicone oil having a viscosity of more than 50 mm2/s but less than or equal to 1000 mm2/sec, and at least the second and third linear silicone oils, and each of them has a viscosity of less than or equal to 50 mm2/S.

2. A composition according to claim 1, characterized in that the first linear silicone oil has a viscosity of more than or equal to 100 mm2/s, even better more than or equal to 200 mm2a /C, escheluchshe more than or equal to 300 mm 2and which can reach 1000 mm2/S.

3. A composition according to claim 1, characterized in that the second and third linear silicone oil having a viscosity less than or equal to 30 mm2/s, better still less than or equal to 20 mm2/s, better still less than or equal to 15 mm2/S.

4. A composition according to claim 1, characterized in that the first linear silicone oil is present in the mixture of linear silicone oils in an amount less than or equal to 20% of the mass. relative to the total weight of the mixture of linear silicone oils, preferably less than or equal to 10 wt.%, better still less than or equal to 5% of the mass.

5. A composition according to claim 1, characterized in that each of the second and third linear silicone oil is present in the mixture of linear silicone oils in an amount greater than or equal to 40% of the mass. relative to the total weight of the mixture of linear silicone oils, preferably more than or equal to 45% of the mass.

6. A composition according to claim 1, characterized in that it contains:
- at least one first linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 100 to 400 mm2/s, preferably from 200 to 300 mm2/s, in particular 350 mm2/s
at least one second linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 1 to 7 mm2 /s, preferably from 2 to 6 mm2/s, in particular 5 mm2/s
- at least one third linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 8 to 20 mm2/s, preferably from 8 to 15 mm2/s, in particular 10 mm2/S.

7. A composition according to claim 1, characterized in that it contains:
- at least one first linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 100 to 400 mm2/s, preferably from 200 to 300 mm2/s, in particular 350 mm2/s, in quantities less than or equal to 20 wt.%, preferably less than or equal to 10 wt.%, the total weight of the linear silicone oils,
at least one second linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 1 to 7 mm2/s, preferably from 2 to 6 mm2/s, in particular 5 mm2/sec, in an amount greater than or equal to 40 wt.%, preferably greater than or equal to 45 wt.%, the total weight of the linear silicone oils,
- at least one third linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 8 to 20 mm2/s, preferably from 8 to 15 mm2/s, in particular 10 mm2/sec, in an amount greater than or equal to 40 wt.%, predpochtitel�but more than or equal to 45 wt.%, the total weight of the linear silicone oils.

8. A composition according to claim 1, characterized in that it contains:
- at least one first linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 100 to 400 mm2/s, preferably from 200 to 300 mm2/s, in particular 350 mm2/sec, in an amount in the range from 0.5 to 15 wt.%, preferably from 1 to 10 wt.%, even better from 1 to 5 wt.%, the total weight of the linear silicone oils,
at least one second linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 1 to 7 mm2/s, preferably from 2 to 6 mm2/s, in particular 5 mm2/sec, in an amount in the range from 40 to 50 wt.%, preferably from 45 to 50 wt.%, better still from 45 to 49.5 wt.%, the total weight of the linear silicone oils,
- at least one third linear silicone oil, preferably a polydimethylsiloxane, having a viscosity in the range from 8 to 20 mm2/s, preferably from 8 to 15 mm2/s, in particular 10 mm2/sec, in an amount in the range from 40 to 55 wt.%, preferably from 42 to 52 wt.%, better still from 45 to 50 wt.%, the total weight of the linear silicone oils.

9. Cosmetic composition containing a mixture:
- particles of hydrophobic aerogel silicon dioxide�, having specific surface area per unit mass (SM) in the range from 500 to 1500 m2/g and a size expressed in average volume diameter (D[0,5]), in the range from 1 to 1500 μm, and
- at least one first linear silicone oil having a viscosity of less than 10 mm2/s, preferably less than or equal to 7 mm2/sec, and more preferably from 3 to 7 mm2/sec, and at least thereof, the second linear silicone oil having a viscosity of more than or equal to 10 mm2/sec, preferably from 10 to 100 mm2/sec, preferably from 10 to 50 mm2/s and preferably from 10 to 30 mm2/S.

10. A composition according to claim 9, characterized in that the relative content of each of these two oils are preferably such that one of the two oils is contained in the amount of at least 1.5 times greater than another.

11. A composition according to claim 1, characterized in that the particles of the hydrophobic aerogel of silica have a specific surface area per unit weight in the range from 600 to 1200 m2/g and better still from 600 to 800 m2/g.

12. A composition according to claim 1, characterized in that the particles of hydrophobic silicon dioxide aerogel have a size, expressed as average volume diameter in the range from 1 to 1000 μm, preferably from 1 to 100 μm, in particular from 1 to 30 μm, preferably from 5 to 25, better still from 5 to 20 μm and even better from 5 to 15 microns.

13. A composition according to claim 1, characterized in that the particles of the hydrophobic aerogel of silica have a specific surface area per unit mass (SM) in the range from 600 to 800 m2/g and a size expressed in average volume diameter (D[0,5]), in the range of 5 to 20 μm and even better from 5 to 15 microns.

14. A composition according to claim 1, characterized in that the particles of hydrophobic silicon dioxide aerogel have a density after compaction in the range from 0.04 g/cm3to 0.10 g/cm3and preferably from 0.05 g/cm3to 0.08 g/cm3.

15. A composition according to claim 1, characterized in that the particles of the hydrophobic aerogel of silica have a specific surface area per unit volume Svin the range of 5 to 60 m2/cm3preferably from 10 to 50 m2/cm3and better still from 15 to 40 m2/cm3.

16. A composition according to claim 1, characterized in that the particles of hydrophobic silicon dioxide aerogel have the capacity oil absorption, measured at a dew point in the range from 5 to 18 ml/g, preferably from 6 to 15 ml/g and better still from 8 to 12 ml/g of particles.

17. A composition according to claim 1, characterized in that the particles of hydrophobic silicon dioxide aerogel particles are of trimethylsilyloxy silicon.

18. A composition according to claim 1, characterized in that the particles of GI�riobravo aerogel silica is present from 0.5 to 30 wt.%, preferably from 1 to 20 wt.%, better from 2 to 15 wt.%, preferably 5 to 10 wt.%, better still from 6 to 8 wt.%, mixture of linear silicone oils and aerogels of silica).

19. A composition according to claim 1, characterized in that silicone oil is present from 80 to 99 wt.%, preferably from 85 to 99 wt%. and better still from 90 to 95 wt.%, total weight of the mixture (linear silicone oils and aerogels of silica).

20. A composition according to claim 1, characterized in that the linear silicone oils are polyorganosiloxanes containing structural units of alkylsilane, and the alkyl groups preferably contain from 1 to 6 carbon atoms and preferably are unsubstituted.

21. A composition according to claim 1, characterized in that the linear silicone oils are selected from polydimethylsiloxane (INCI name: Dimethicone), preferably of the formula:

in which x denotes an integer chosen so that it had a liquid connection.

22. A composition according to claim 1, characterized in that it contains from 0.1 to 90 wt.%, preferably from 1 to 80 wt.%, better still from 2 to 30 wt%. and even better from 2 to 20 wt.%, mixtures of silicone oils and particles of silicon dioxide aerogel).

23. A cosmetic method of treatment and/or caring for keratin materials, comprising the step of applying a composition according to any�the mu one of claims. 1-22 on these materials.



 

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22 cl, 3 ex

FIELD: medicine.

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23 cl, 10 tbl, 11 ex

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9 cl, 1 ex, 1 tbl

FIELD: chemistry.

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19 cl, 3 tbl, 1 ex

Shower gel // 2555358

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3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to liposomal compositions for application in cosmetic industry, including i) from 0.001 to 1 wt % of cyclo-(Arg-Gly-Asp-DPhe-Acha) and/or its salt or solvate, ii) from 0.01 to 20 wt % of one or more lipids; iii) from 60 to 99.99 wt % of one or more physiologically acceptable solvents, as well as to method of their obtaining and application for care and preservation of general condition of skin or hare, for prevention or reduction of wrinkles.

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18 cl, 3 dwg, 29 tbl, 18 ex

FIELD: chemistry.

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3 dwg, 1 tbl

FIELD: chemistry.

SUBSTANCE: group of inventions relates to an oral care composition and method of making thereof. An oral care composition comprising a film in an amount of 0.1 wt % to 5.0 wt %, entrained in a carrier, wherein the film comprises a non-ionic surfactant polysorbate 80 in an amount from 10.5 wt % of the film to 20 wt % of the film and a solid calcium peroxide in the amount of 20% to 65% of the film weight. The film may further comprise a therapeutic active in the amount of 0.01 to 30 wt % of the film. The method of making an oral care composition being a dental care product, comprises as follows: (a) providing the carrier; (b) adding lamellar fragments of the film comprising polysorbate, in an amount of from 10.5 wt % of the film to 20 wt % of the film and a solid ingredient comprising calcium peroxide in an amount of from 20 wt % of the film to 65 wt % of the film; and (c) homogenizing the mixture, whereas the film is present in the amount of 0.1 wt % to 5.0 wt % of the of the total weigh of the composition.

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6 cl, 5 tbl, 1 ex

FIELD: medicine, pharmaceutics.

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22 cl, 3 ex

FIELD: medicine, pharmaceutics.

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11 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and is intended for oral cavity care. Compositions contain non-dialysable material of cranberry extract, in which non-dialysable material of cranberry extract is present in quantity, effective for inhibiting co-aggregation of oral cavity bacteria and/or inhibiting bacterial growth.

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15 cl, 5 tbl, 4 ex

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2 tbl, 1 ex

Black adler syrup // 2557929

FIELD: medicine.

SUBSTANCE: black adler syrup having laxative action, characterised by the fact that it is produced by preparing black adler tea by boiling the raw material with purified water; the tea is further mixed with refined sugar; the mixture is heated until the sugar is dissolved completely and brought to boil twice with skimming as often as it may be required; the prepared syrup is filtered through gauze in the certain environment.

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2 dwg, 1 ex

FIELD: medicine.

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EFFECT: cosmetic product enables extending the range of products for improving the skin state, reducing the risk of lower controllability of the effect, and a probability of allergic and inflammatory reactions.

3 cl, 10 ex

FIELD: medicine.

SUBSTANCE: using a polyphenolic complex produced by extracting milled ash berry in 40% ethanol, condensing the alcohol-water extract, adding 95% ethanol, centrifuging the residue, filtering and condensing the supernatant in the certain environment, as an agent possessing anti-inflammatory action.

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1 dwg, 9 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to veterinary science and is applicable for treating bovine mastitis. What is declared is a nosode for producing a preparation for treating bovine mastitis. That involves taking mastitis milk 1 ml with clinical signs of purulent-catarrhal mastitis, filling it 70° alcohol 9 ml to produce a homogenous solution; the produced solution is diluted to "Д6" with 70° alcohol. What is also declared is a preparation for treating bovine mastitis containing an aqueous-alcoholic solution of components. The components are Belladonna, Sulphur, Apis mellifica, Conium, Phytolacca, Silicea and above nosode in the following proportions, wt %: Belladonna - 5, Sulphur - 20, Apis mellifica - 20, Conium - 10, Phytolacca - 10, Silicea - 5, nosode - 15, aqueous-alcoholic solution up to 100%. What is also declared is a method of treating bovine mastitis involving the intracisternal administration of the preparation. The preparation is administered in a dose of 5-10 ml per 1 animal once a day.

EFFECT: declared group of inventions is highly effective in treating bovine mastitis.

3 cl, 5 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical composition, containing compound of formula or for prevention or treatment of diseases, associated with oxidative stress, selected from group, consisting of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke episodes), MERRF syndrome (myoclonic epilepsy with ragged red fibres) or Kearns-Sayre syndrome, arrhythmia, cardioplegia or myocardium infarction. in formula (1) na stands for 1 or 2, Aa represents 5-membered heteroaryl or heterocycle, each of which has 2 heteroatoms, selected from N, O and S, Rla represents R5a-Xa-Ba-X′a-, Ba represents direct bond, Xa and X′a independently on each other represent direct bond or -OC(O)-, R5a represents hydrogen or 6-9-membered monocyclic or condensed cyclic heterocycle or heteroaryl, each of which has from 1 to 3 heteroatoms, selected from N, O and S, and is optionally substituted with oxo or C1-C6-alkyl, R2a represents -(CR8aR9a)pa-Ya-R7a, pa stands for number from 0 or 1, Ya represents direct bond or -O-, R7a represents hydrogen or phenyl, R3a, R8a, R9a, R10a represent hydrogen, R4a represents -(CH2)pa-Da-R10a-, Da represents C5-cycloalkyl or 6-membered heterocycle, which has 1 heteroatom, selected from N, S and O. Radical values for formula (2) are give in invention formula.

EFFECT: obtaining compositions for prevention or treatment of diseases, associated with oxidative stress.

19 dwg, 5 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: opening of a carious cavity, ablation of overhanging enamel edges on the entire circumference, necrectomy and drug treatment with a 0.06% chlorhexidine solution are performed. The preparation "Lemifaren" is applied on walls and bottom of the carious cavity in a uniform 1 mm thick layer, which is left for 1 day under temporary filling. After the removal of the preparation irradiation in a pulse mode with the power of 5 W and frequency of 2000-3000 Hz is carried out for 5 min with the application of the laser apparatus ALST-01. After that, the cavity is restored with an account of functional and aesthetic parameters of the particular tooth.

EFFECT: effective treatment of deep caries prevents caries recurrences and pulp inflammation.

1 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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