Method of treatment of urinogenital mycoplasmosis of dogs

FIELD: veterinary medicine.

SUBSTANCE: method comprises subcutaneous administration of antibiotic preparation enroxyl 5% at a dose of 0.1 ml/kg daily one time a day for 7 days and intramuscular administration of homeopathic preparation ovarinin at a dose of 1 ml/kg one time for 4 days, 4-fold.

EFFECT: use of the invention enables to increase the efficiency of treatment, to reduce treatment time and to restore reproductive function of dogs.

2 tbl, 1 ex

 

The invention relates to veterinary medicine, namely to method of treatment of urogenital Mycoplasma dogs.

Mycoplasma is widely distributed in nature, some species may be pathogenic to plants and to humans or warm-blooded animals [Kovalenko, I. R. Mycoplasma animals / Ya. R. Kovalenko. M.: Kolos, 1976. - P. 14].

The Mycoplasma animals - a group of infectious diseases caused by microorganisms of the class Mollicutes.

In dogs frequently diagnosed with urogenital diseases caused by representatives of Mycoplasma and Ureaplasma, which are normally found in the urogenital system of a healthy animal.

Transmission is usually through sexual contact, but can also be airborne route of transmission. Mycoplasmosis dogs possible resorption of embryos, abortiona, puppies are born underdeveloped, there is a high neonatal mortality in the first days of life. Females are registered obstetric-gynecological diseases, difficult to treat, in males - posthitides, urethritis, prostatitis, orchiepididymitis, swelling of the scrotum, reduced fertility [Sochnev V. V. Mixed infections of carnivores in urban areas / Vladimir Sochnev, Medova, E. V., J. V. Pashkina, E. A. Grachev et al. / / Veterinary pathology, 2006. - No. 3. - P. 72-74].

Since small animals are the most�e close contact with the person there is a real risk of transmission from animal to man. Similar lesions of the urogenital tract have been observed in humans, with a specific pathogen is Mycoplasma and Ureaplasma [Novikova N. N. Rapid methods of diagnosis associative urogenital mycoplasmosis carnivores: author. dis. on competition. exercises. step. Cand. blows.Sciences/ N. N. Novikov. - Novosibirsk, 2002. - C. 3].

Well-known medication for the treatment of bacterial infections of animals and birds, complicated by mycoplasmosis. The product contains tylosin, chloramphenicol, and also solvents or fillers, stabilizers and preservatives in the following ratio of components, wt.%: tylosin 0.25 to 50.0, the chloramphenicol 2,5-90,0, solvents or fillers, stabilizers, preservatives, and 100. The combined use of tylosin and chloramphenicol can improve therapeutic efficacy by 2.13% and 2.64% respectively in comparison with the separate use of tylosin and chloramphenicol, as well as to reduce the content of tylosin 5 times (Patent 2162690 EN).

A method of treating mycoplasmosis in animals with the use of the antibiotic tetracycline (lieterally) and immunomodulator WESTIN or algerina according to the following scheme: intramuscularly, lieterally 0.4 ml/kg and almarin 400 IU/kg of 1 every 15 days or lieterally 0.4 ml/kg and WESTIN 0.06 mg/kg 1 every 15 d�her. The method allows to increase the effectiveness of the treatment of animals by reducing the time of treatment (Patent 2219915 EN).

The closest solution adopted for the prototype, is a famous drug that promotes the elimination of Mycoplasma. Among antibiotics in veterinary medicine the most widely used tylosin [Leshchinskaya I. Macrolides are the drugs of choice to combat Mycoplasma animals / I. I. Leszczynski // RVI Shi, 2009. - No. 1. - S. 44-45]. Also used homeopathic medicines: mistometer, Larsen, which stimulates the immune system and enhances reproductive function carnivorous. Females foxes experimental groups after application of malamatina exit puppies to the main female was significantly higher than in the control group on average 23,91-23,78%, and significantly lower the waste of young animals before registering on average, 4,49-6,29% against 20,44% in the control group (Kocheva N. And. Homeopathic methods of correction of reproductive function of female Arctic Fox / N. And. Kocheva, V. N. Bochkarev, N. In. Varnava // Veterinary pathology, 2007. - No. 3. - P. 204-207).

A disadvantage of the use of antibiotics is a relatively low efficiency due to the emergence of resistant forms of Mycoplasma in the prolonged usage of antibiotics in doses below therapeutic level.

A method for the treatment of urogenital mycoplasmosis dogs distinguishes�I, that as the causal substance is a fluoroquinolone antibiotic and homeopathic medicine.

The invention consists in the fact that the causal substance use antibiotics enroxil 5%, as well as a homeopathic drug barynin. Dogs injected subcutaneously enroxil 5% at a dose of 0.1 ml/kg daily 1 time per day for 7 days and intramuscularly barynin at a dose of 1 ml/kg 1 every 4 days, 4 times.

Enroxil 5% belongs to the group of fluoroquinolones and has a broad spectrum of bactericidal action is based on inhibition of replication of bacterial DNA. Enrofloxacin is active against gram-positive and gram-negative microorganisms.

Barynin contains as active ingredients homeopathic substance: Apis mellifelica - C12; Pulsatilla pratensis - C30; Sulfur - C200; Sepia - C30; Creazotum - C30; Lachesis - C12. Barynin restores metabolism, affects the immune and Central nervous system that leads to a cascade of biological responses at the molecular and submolecular levels in the cells of the body, leading to reparative, anti-inflammatory, restorative processes and changes in hormonal status.

An example of a method

When designing an optimal scheme of treatment of dogs with urogenital syndrome caused by Mycoplasma and chlamydia, used dogs in�of TRASTA from 2 to 6 years, divided according to the principle analogues into three groups: 2 experimental and 1 control, 10 animals each. The inclusion criteria in the group of study: accounting General condition and severity of the disease, positive laboratory tests for mycoplasmal and chlamydial infection, the presence of animals in the same conditions of keeping and feeding.

As a result of the different treatment regimens was evaluated clinico-therapeutic effect. Assessment of effectiveness was carried out by the disappearance of clinical symptoms (table.1).

The recovered animals was a restoration of the sexual cycle and reproductive function (table.2).

Thus, the clinical therapeutic effect of the treatment regimen with the use of antibiotic enroxil 5% and homeopathic drug barynin at a dose of 1 ml/kg in the treatment of urogenital syndrome caused by Mycoplasma and chlamydia, was to increase the effectiveness of treatment by 40%, reducing the duration of treatment for 2 days compared with monotherapy antibacterial drug, and in 85.7% of the reproductive function recovered animals and opportunities to avoid surgical intervention.

A method for the treatment of urogenital mycoplasmosis dogs, including the introduction of anti�jotika, characterized in that the antibiotic is administered subcutaneously enroxil 5% at a dose of 0.1 ml/kg daily 1 time per day for 7 days and intramuscularly barynin at a dose of 1 ml/kg 1 every 4 days, 4 times.



 

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