Method for producing microcapsules of antioxidants

FIELD: chemistry.

SUBSTANCE: invention relates to microencapsulation, in particular, to microencapsulation of antioxidants. Carrageenan was used for the capsule shells, an antioxidant was selected from the group of: vitamins A, C, E, Q10, eleuterococcus, green tea extract, ginseng extract; wherein an antioxidant product portion was dissolved in dimethylsulfoxide, and the mixture was dispersed in a solution of carrageenan in ethanol in the presence of the preparation E472c under stirring at the rate of 1300 rev/s, the antioxidant/carrageenan weight ratio was 1:3, after which a mixture of benzene and water taken in volume ratio of 2:1 was added to the above mix, the resulted suspension was filtered and dried at a room temperature.

EFFECT: simplified and fast process of antioxidant product microencapsulation in carrageenan.

1 ex

 

The invention relates to the field of encapsulation.

Previously known methods for producing microcapsules.

In us Pat. 2173140, IPC AC 009/50, AK 009/127, Russian Federation, published 10.09.2001, a method of producing kremnijorganicheskih microcapsules using a rotary cavitation equipment with high shear forces and powerful hydroacoustic phenomena sonic and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - rotary-cavitational installation, which has the ultrasonic effect, which influences the formation of the microcapsules and thus may cause adverse reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when working with polymers of synthetic origin

In us Pat. 2359662, IPC AC 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 27.06.2009, Russian Federation, proposed a method of obtaining microcapsules of sodium chloride with the use of spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min Microcapsules according to the invention have improved stability and provide�t adjustable and/or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, certain set of conditions (the air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm).

The closest method is the method proposed in us Pat. 2134967, IPC A01N 53/00, A01N 25/28, published 27.08.1999, Russian Federation (1999). In water dispersed solution of a mixture of natural lipids and PYRETHROID insecticide in a weight ratio of 2-4:1 in an organic solvent, which leads to simplification of the method of microencapsulation.

The disadvantage is the dispersion in an aqueous medium, which makes the proposed method applicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of production of microcapsules, reducing loss upon receipt of the microcapsules (increase of the yield by weight).

The solution of a technical problem is achieved by a method of obtaining microcapsules of antioxidants, possessing supramolecular properties, characterized in that as the shell of the microcapsules used carrageenan, and as the kernel is an antioxidant when receiving the encapsulated particles by deposition of nerastvorim with the use of butanol and benzene as sieges�carriers, the process of obtaining microcapsules is carried out without special equipment.

A distinctive feature of the proposed method is the production of microcapsules by the method of deposition by nerastvorim using butanol and benzene as precipitants, and the use of carrageenan as the shell of the particles and of the antioxidant - as the kernel.

The result of the proposed method is to obtain microcapsules of antioxidants: vitamins A, C, E, Q10, Siberian ginseng, green tea extract, extract of a ginseng.

EXAMPLE 1. Obtaining microcapsules of antioxidants in carrageenan (type of experience)

100 mg of antioxidant dissolved in 1 ml of dimethyl sulfoxide and the resulting mixture was dispersed in a suspension of carrageenan in butanol containing 300 mg of the specified polymer, in the presence of 0.01 g of the drug Is (an ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid as tribasic can be etherification other glycerides and as oxanilate - other fatty acids; free acid groups can be neutralized with sodium) with stirring 1300 R/S. Next, pour 2 ml of benzene and 1 ml of water. The resulting suspension was filtered and dried at room temperature.

Received 0,396 g of powder of microcapsules. Vyho� was 99%.

A method of producing microcapsules of antioxidants, characterized by the fact that as the shell of the microcapsules used carrageenan as an antioxidant choose one of the following substances: vitamins a, C, E, Q10, Siberian ginseng extract, green tea extract, a ginseng, a portion of the antioxidant dissolved in dimethylsulfoxide, was dispersed in a suspension of carrageenan in butanol in the presence of surfactants Is with stirring 1300 R/C, while the mass ratio between the amounts of antioxidant and carrageenan in terms of dry substance is 1:3, obtained mixture is poured a mixture of benzene and water, taken in a volume ratio of 2:1, the resulting suspension was filtered and dried at room temperature.



 

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