Black adler syrup

FIELD: medicine.

SUBSTANCE: black adler syrup having laxative action, characterised by the fact that it is produced by preparing black adler tea by boiling the raw material with purified water; the tea is further mixed with refined sugar; the mixture is heated until the sugar is dissolved completely and brought to boil twice with skimming as often as it may be required; the prepared syrup is filtered through gauze in the certain environment.

EFFECT: syrup is high in anthracene derivatives and possesses the pronounced laxative action.

2 dwg, 1 ex

 

The invention relates to chemical-pharmaceutical industry, in particular to the production of a pharmaceutical agent that has a laxative effect, the syrup obtained by water extraction from bark of buckthorn (Frangula alnus Mill.) (1).

In official medicine as a source of laxatives widely used buckthorn bark brittle due to the high content in it anthracenedione. The Russian Federation has registered the following medications derived from bark of buckthorn: Buckthorn extract tablets, coated 0.2 g" and "Buckthorn syrup" (2).

"Buckthorn syrup" was selected as a prototype of the invention. It is known that liquid dosage forms are more bioavailable because the active ingredients are already in dissolved form. However, in the production of 1 liter prototype used an aqueous extract of 830 g buckthorn bark, raising questions regarding the completeness of the extraction of active compounds from medicinal plants. Small release of active compounds leads to inefficient use of raw materials and inefficient economic costs (2).

Thus, the aim of the invention is to provide a composition and a more rational technology of syrup.

The technical result of the proposed method �is obtaining syrup of buckthorn bark brittle with use of more efficient technologies, saving of raw materials three times.

This object is achieved in that in the beginning a decoction from the bark of buckthorn in the ratio 1:3 by boiling for 15 min and the use of extract obtained in the manufacture of syrup of the following composition:

A decoction of buckthorn bark brittle (1:3)36,0
Refined sugarOf 64.0

To study the UV spectra of the obtained syrups in alkali-ammonia medium and the quantitative determination of anthracenedione, an accurately weighed sample of syrup (2.0 g) was placed in a volumetric flask with a capacity of 25 ml, was diluted to the mark and stirred (original solution). 2 ml of the resulting solution was placed in a volumetric flask with a capacity of 25 ml and was adjusted to the mark alkali-ammonia solution (test solution). The test solution was heated for 15 min in a boiling water bath.

After cooling, removed the electronic spectrum of the test solution in the range 190-700 nm. As of the reference solution used used purified water.

The content of the sum of anthracenedione (X) in terms of glucofrangulin frangulin A percentage calculated as follows:

where D is the optical density of the test solution;

D0optic n�otnesti solution RDF mangulina A;

m is the mass of a sample of syrup, g;

m0- mass RDF mangulina And,

When no standard sample mangulina And it is advisable to use theoretical value of the specific rate of absorption - 180 (3,4):

where D is the optical density of the test solution;

180 - specific absorption coefficientalkali-ammonia solution RDF mangulina And at 524 nm.

For the quantitative determination of anthracenedione investigated in the initial samples buckthorn bark used a previously developed methodology (extractant - 40% ethanol, ratio of raw material:extractant 1:50, the extraction time of 90 min) (3, 4).

The inventive method is implemented by the following example.

Example 1. 12.0 g buckthorn bark raw material filled in 62 ml (taking into account the coefficient of water absorption) of purified water at room temperature, was heated on a hotplate to boil, boil the contents of the flask for 15 min, cooled for 15 min, filtered and adjusted, if necessary, obtained to the required volume ratio of raw material:a decoction of 1:3.

Water extraction from bark of buckthorn (decoction) was used instead of purified water to obtain a sugar syrups pharmacopoeial method. For this, 36 g of decoction was mixed with 64 g of refined sugar and heated the mixture until the sugar is dissolved, bring to Ki�message twice each time removing the resulting foam. The syrup was filtered through cheesecloth in hot form and brought to the initial mass of purified water.

The content of the sum of anthracenedione in the finished product in terms of glucofrangulin frangulin And was 0.37±0,02% (yield from raw materials 47,7±0,4%).

The purpose of the comparison received syrup of buckthorn brittle following compositions: syrups derived similarly to the inventive method, but using broth 1:1 (prototype), 1:6, 1:3 when heated in a water bath. The resulting syrups were less sum of anthracenedione (in syrup of decoction of 1:6 content was 0.15%±0,01%; flavor broth 1:3 (heating in a water bath) - 0,30±0,02%), except for the syrup, corresponding to the prototype, in which the content did not differ statistically significantly from the proposed composition and amounted 0,39±0,02%. However, all the syrups were inferior to the proposed composition of output the amount of anthracenedione of raw material: syrup decoction 1:6 output is 38.6±0,5%, in syrup of decoction of 1:3 (heating in a water bath) of 31.6±0,4%; in syrup-prototype output was the lowest of the considered examples and was 18.1±0,5% (Fig. 1).

Comparative characteristics of the considered method and the method prototype is shown in Fig. 1. On the basis of obtained data we can conclude that the proposed method is characterized by more wysockiego existing connections and not inferior to the prototype method for the quantitative content of anthracenedione. Technology is also more rational, so as the same amount of syrup is obtained from the quantity of raw materials, three times smaller in comparison with the prototype.

Also conducted a comparative evaluation of the laxative effect of syrup of buckthorn, obtained the claimed method, and syrup of buckthorn (prototype). For this white mongrel rats-albinos of both sexes weighing 250 g, fed last 6 hours before the experiment (standard diet of the vivarium), were placed separately in cages, with clean filter paper. Experimental and control groups were composed of 10 animals each. The study drugs were administered to animals in the experimental groups intraperitoneally in amounts equivalent to dosages of 5 mg/kg, 10 mg/kg, 25 mg/kg 50 mg/kg and 100 mg/kg in recalculation on anthracenedione (Fig. 2). In the case of a large volume of administered drugs (over 8 ml) broth, including for the preparation of syrups, evaporated. 18 hours after administration of test samples were calculated with a total number of faeces from each animal of all analyzed groups. The percentage increase of the faeces and the proportion of wet faeces from their total number was considered a laxative effect.

Determined that in the case of syrup of buckthorn, obtained the claimed method, the maximum laxative effect is achieved at a dose of 50 mg/kg, whereas in the case of the proto�IPA comparative laxative effect is achieved at a dose of 100 mg/kg (Fig. 2). Consequently, syrup of buckthorn, obtained the claimed method, in 2 times is more active some syrup of buckthorn, obtained by the method prototype.

Sources of information

1. Kurkin V. A. Fundamentals of herbal medicine: a textbook for students of pharmaceutical universities. - Samara: LLC "Etching", GOU VPO "Samara state medical University of Roszdrav", 2009. - 963 S.

2. The state register of drugs // the Ministry of health of the Russian Federation. URL: http://grls.rosminzdrav.ru/default.aspx (reference date: 02.02.2014 g ).

3. Kurkin V. A., Sigareva A. A. Determination of anthracenedione in the buckthorn bark brittle // pharmacy. - 2010. - Vol. 58. - No. 8. - S. 9-12.

4. Kurkin V. A., Sigareva A. A. Phytochemical investigation of buckthorn bark brittle // Medical almanac. - 2012. - №1 (20). - P. 218-220.

5. Chueshov V. I., Chernov, M. Y., Khokhlova L. M., etc. Industrial technology of drugs: a Textbook for students of higher educational institutions. In 2 vols 2 - Kharkiv: NUPH MTC. Book, 1999. - 704 S.

Syrup of buckthorn bark brittle, has a laxative effect, characterized in that it is obtained by preparation of decoction of buckthorn bark brittle at a ratio of raw material:a decoction of 1:3 by boiling raw material with the purified water for 15 min, then 36 g of decoction was mixed with 64 g of refined sugar, heat the mixture until the sugar is dissolved, bring to the boil twice, each time removing obesulus� foam, the resulting syrup was filtered through cheesecloth.



 

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