Method of production of nanocapsules of vitamins

FIELD: nanotechnology.

SUBSTANCE: method of production of nanocapsules of vitamin in sodium alginate is characterized in that the shell is used as sodium alginate, and the core - as the vitamin, in a weight ratio of core:shell as 1:3. According to the method of preparing the nanocapsules the vitamin is added to a suspension of sodium alginate in benzene in the presence of the preparation E472s while stirring at 1300 rev/sec. Then hexane is added, the resulting suspension is filtered and dried at room temperature.

EFFECT: simplification and acceleration of the process of production of the nanocapsules, and increase in the yield by weight.

3 dwg, 8 ex

 

The invention relates to the field of nanotechnology, medicine and food industries.

Previously known methods for producing microcapsules.

In us Pat. 2173140, IPC A61K 009/50, A61K 009/127, Russian Federation, published 10.09.2001, a method of producing kremnijorganicheskih microcapsules using a rotary cavitation equipment with high shear forces and powerful hydroacoustic phenomena sonic and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - rotary-cavitational installation, which has the ultrasonic effect, which influences the formation of the microcapsules and thus may cause adverse reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when working with polymers of synthetic origin

In us Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 27.06.2009, Russian Federation, proposed a method of obtaining microcapsules of sodium chloride with the use of spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min Microcapsules according to the invention possess�t improved stability and provide adjustable and/or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, certain set of conditions (the air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min).

The closest method is the method proposed in us Pat. 2134967, IPC A01N 53/00, A01N 25/28, published 27.08.1999, Russian Federation (1999). In water dispersed solution of a mixture of natural lipids and PYRETHROID insecticide in a weight ratio of 2-4:1 in an organic solvent, which leads to simplification of the method of microencapsulation.

The disadvantage is the dispersion in an aqueous medium, which makes the proposed method applicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of producing nanocapsules, reduction of losses in obtaining nanocapsules (increase of the yield by weight).

The solution of a technical problem is achieved by a method of obtaining nanocapsules vitamins, characterized in that as the shell of the nanocapsules used sodium alginate, and as the kernel - vitamins (A, C, D, E, Q10upon receipt of nanocapsules by deposition of nerastvorim with the use of hexane as the precipitant, the process of obtaining nanocapsules made� without special equipment.

A distinctive feature of the proposed method is to obtain nanocapsules by deposition of nerastvorim using hexane as the precipitant, and the use of sodium alginate as the shell particles and vitamins - as the kernel.

The result of the proposed method are obtaining nanocapsules of vitamins A, C, D, E, Q10and also and extracts of Eleutherococcus and ginseng.

EXAMPLE 1. Obtaining nanocapsules of vitamin A in the sodium alginate, the ratio of core:shell 1:3

100 mg of vitamin A are added to a suspension of sodium alginate in benzene containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug E472c (an ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid, tribasic, can be etherification other glycerides and as oxanilate - other fatty acids. Free acid groups can be neutralized with sodium) with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. The resulting suspension was filtered and dried at room temperature.

Received 0,396 g of powder of nanocapsules. The yield was 99%.

EXAMPLE 2. Obtaining nanocapsules of vitamin C in the sodium alginate, the ratio of core:shell 1:3

100 mg of vitamin C is added to a suspension of sodium alginate in benzene, with�argasi specified 300 mg of the polymer in the presence of 0.01 g of the drug E472c with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 3. Obtaining nanocapsules of vitamin D in the sodium alginate, the ratio of core:shell 1:3

100 mg of vitamin D is added to a suspension of sodium alginate in benzene containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug E472c with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 4. Obtaining nanocapsules of vitamin E in the sodium alginate, the ratio of core:shell 1:3

100 mg of vitamin E added to a suspension of sodium alginate in benzene containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug E472c with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 5. Obtaining nanocapsules vitamin Q10in the sodium alginate, the ratio of core:shell 1:3

100 mg vitamin Q10added to a suspension of sodium alginate in benzene containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug E472c with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. Paul�obtained suspension was filtered and dried at room temperature.

Received 0,396 g of powder of nanocapsules. The yield was 99%.

EXAMPLE 6. Obtaining nanocapsules of the extract of Eleutherococcus in the sodium alginate, the ratio of core:shell 1:3

100 mg of extract eleutheroccus added to a suspension of sodium alginate in benzene containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 7. Obtaining nanocapsules of ginseng extract in the sodium alginate, the ratio of core:shell 1:3

100 mg of ginseng extract is added to a suspension of sodium alginate in benzene containing the specified 300 mg of the polymer in the presence of 0.01 g of the drug As with stirring 1300 Rev/sec. Next, pour 2 ml of hexane. The resulting suspension was filtered and dried at room temperature.

Obtained 0.4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 8. Determination of the amount of nanocapsule vitamins NTA method

The measurements were multiparametric analyzer Nanosight nanoparticle LM0 production Nanosight Ltd (UK) in the configuration of the HS-BF (high-sensitivity video camera Andor Luca, a semiconductor laser with a wavelength of 405 nm and a power of 45 mW). The device is based on the method of analysis of the trajectories of nanocast� (Nanoparticle Tracking Analysis, NTA), described in ASTM E2834.

The optimal dilution for dilution was chosen as 1:100. For measurements were selected instrument parameters: Camera Level = 16, Detection Threshold = 10 (multi), Min Track Length: Auto, Min Expected Size:

Auto. the duration of a single measurement 215s, the use of a syringe pump.

A method of producing nanocapsules in vitamin sodium alginate, characterized in that as the shell is used sodium alginate, and as the kernel - vitamin, at a weight ratio of core:shell 1:3, wherein the vitamin is added to a suspension of sodium alginate in benzene in the presence of the drug As with stirring 1300 Rev/sec, then added hexane, the resulting suspension was filtered and dried at room temperature.



 

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