Method for prediction of clinical course of bronchitis in calves

FIELD: chemistry.

SUBSTANCE: invention refers to veterinary science and can be used for the prediction of the clinical course of bronchitis in calves. That is ensured by measuring body temperature, heart rate and respiration rate per a minute. That is ensured by calculating a respiratory disturbance index (RDI) as a relation of the respiration rate per a minute following a 30-second expiratory induced breath holding to the rest respiration rate per a minute. A Hildebrandt index is calculated as a relation of the heart rate to respiration rate per a minute. The derived data are analysed. If the body temperature is 37.5÷39.6°C, the heart rate is less than 100 per a minute, the respiration rate is less than 40 per a minute, the RDI is more than 1.4, whereas the Hildebrandt index is more than 1.8, the animal's absolute recovery or the benign clinical course of the disease is predicted (a favourable prognosis, prognosis bona). If the body temperature is more than 39.5°C, the heart rate is 90÷120 per a minute, the respiration rate is 40÷60 per a minute, the RDI is 1.2÷2.5, whereas the Hildebrandt index ranges within 1.7÷3.1, a probability of the unfavourable clinical course of the disease is predicted (a doubtful prognosis, prognosis dubia). If the body temperature is 39.5°C, the heart rate is more than 100 per a minute, the respiration rate is more than 60 per a minutes, the RDI is less than 1.2, whereas the Hildebrandt index is more than 1.8, the animal's partial recovery or the malignant clinical course of the disease is predicted (an unfavourable prognosis, prognosis bona).

EFFECT: method offers the prospect of the objective prediction of the clinical course of bronchitis in calves, including of the potential development of the complications, namely bronchial pneumonia, that in turn enables specifying a therapeutic approach and controlling the clinical effectiveness.

2 tbl, 2 ex

 

The invention relates to veterinary medicine and can be used for predicting the course of bronchitis in calves.

Bronchitis is an inflammation of the mucosa and submucosa of the bronchi. Mass distribution of bronchitis in cattle see on specialized farms and complexes for fattening of calves and growing heifers for violation of veterinary-sanitary and hygienic requirements of keeping and feeding animals. Adrift distinguish acute and chronic bronchitis. Depending on the localization of the inflammatory process - microbranches, when the inflammatory process is localized in the large bronchi, microbranches, when the process involves the small bronchi, and diffuse bronchitis, the inflammation spreads throughout the bronchial tree. Depending on the nature of the inflammatory exudate bronchitis may be catarrhal, fibrinous, purulent, putrid and hemorrhagic [Anokhin B. M. Internal non-infectious diseases of farm animals / by B. M. Anokhin, V. M. Danilevsky, L. G. Samarin, X. Z. Ibragimov, I. M. Karpati, I. P. Kondrakhin, A. V. Korobov, L. M. Obukhov, Φ.F. Prokhorov, V. S. Slovin, N. And. Sudakov, V. A., Telepnev; ed. by V. M. Danilevsky. - M.: Agropromizdat, 1991. - Pp. 134-139].

Forecast (from the Greek. prognosis - prediction, prediction) - prediction of the development and outcome of disease, based on knowledge �of economiesthe of pathological processes and objective data. Prediction of course and outcome of disease is essential to determine therapeutic tactics. The content of the prognosis may be favourable (prognosis bona), when a full recovery is expected or benign course of illness, questionable (prognosis dubia), when not excluded unfavorable course of the disease and unfavorable prognosis mala), when it is expected to incomplete recovery or malignant disease [Smirnov, A. M. Clinical diagnosis of internal non-infectious diseases of farm animals / by A. M. Smirnov, P. J. Konopelko, V. S. Postnikov, I. M. Belyakov, G. L. Dugin, R. P. Pushkarev, V. S. Kondrat'ev, N. And. Urazaev. - Leningrad: Kolos. Of Leningrad. -DEP, 1981. - S. 26-134]. Prediction of course and outcome of disease can also be very poor (prognosis pessima) or directly pointing to the inevitability of fatal outcome (prognosis letalis), however, in relation to bronchitis in calves, these types of forecast are extremely rare.

With a favorable course of bronchitis, when eliminated etiological factors and treatment, the body through compensatory mechanisms (increased respiration, activation of cardiovascular activity, mobilization of cellular and humoral protective factors, etc.) cope with pathological changes and recovery occurs. With the unfavorable course of the disease inflammatory proce�with spreads to lung tissue, develops bronchopneumonia.

A method of predicting the development of respiratory diseases in newborn calves [RU 2491550 C1, G01N 33/49, 27.08.2013, bull. No. 24], providing for the taking of blood in calves within 24 hours after birth, the determination in serum of calcium and magnesium, the calculation of the calcium-magnesium ratio. In the case of values of the calcium-magnesium ratio in the serum of less than 3,50:1 in calves predict the development of respiratory diseases.

The disadvantages of this method are: the impossibility to predict the course and outcome of respiratory diseases in calves, a long time from the moment of blood sampling until the results of the research, the need for special facilities, laboratory equipment and highly qualified personnel.

Known method for the diagnosis and prediction of bronchopneumonia of calves by biochemical test [Kondrakhin I. P. Methods of diagnosing and predicting the bronchopneumonia of calves by biochemical test / I. P. Kondrakhin // veterinary medicine. - 1997. - No. 12. - S. 43-45], based on identifying dysproteinemia (hyperglobulinemia and hypoalbuminemia) inherent bronchopneumonia (pneumonia).

The disadvantages of this method are: the impossibility to predict the course and outcome of bronchitis in calves, the need for special facilities, laboratory equipment�tion and highly qualified personnel.

The closest in essence to the claimed method is a method of diagnosis of respiratory distress in calves [Zolotarev A. I. Diagnosis of respiratory distress in calves / A. I. Zolotarev, A. E. Chernitsky, A. M. samotin, M. I. Retskiy // veterinary medicine. - 2014. - No. 6. - S. 46-50], based on the definition in calves index of respiratory failure (IDN), calculated as the ratio of the frequency of respiratory movements per minute after 30 seconds artificial breath hold (apnea) during expiration to the frequency of respiratory movements per minute at rest. In healthy calves IDN is 1.1-1.5, when a latent respiratory failure - more than 1.5. It is known that in case of respiratory failure the first and second degrees it is possible to compensate the impaired gas exchange, and oxygen deficiency in the blood is not observed. Respiratory failure third degree is accompanied by hypoxia and / or hypercapnia, can induce coma and cause death of the animal. This method is taken as a prototype.

The main disadvantage of this method is the inability to predict the course of bronchitis in calves.

The technical result of the invention is the prediction of the course of bronchitis in calves.

To achieve the technical result of the method of predicting the course of bronchitis in calves includes determining the body temperature, the frequency with�technich rate (HR) and frequency of respiratory movements (NPV) per minute, the index of respiratory failure (IDN) as the ratio of the frequency of respiratory movements per minute after 30 seconds artificial breath on the exhale to the frequency of respiratory movements per minute at rest, the calculation of the index Hildebrandt as the ratio of heart rate to respiratory rate per minute, data analysis and forecasting full recovery of the animal or benign course of the disease (favorable prognosis, the prognosis bona) at body temperature of 37.5÷39,6°C, heart rate less than 100 / minute, respiratory rate less 40 per minute, the values of the Eden and more than 1.4 index of more than 1.8 Hildebrandt, prediction of possible adverse course of the disease (questionable prognosis, prognosis dubia) at body temperature of more than 39.5°C, heart rate of 90÷120 per minute, respiratory rate 40 to 60 per minute, the values of the Eden 1,2÷2,5 and index Hildebrandt 1,7÷3,1, forecasting incomplete recovery of the animal or malignant course of the disease (poor prognosis, the prognosis mala) at body temperature of more than 39.5°C, heart rate over 100 per minute, respiratory rate over 60 per minute, the IDN values less than 1.2 and index Hildebrandt less than 1.8.

Thermometry is the mandatory method of clinical research. It allows you to assess the condition of the animal, to monitor the course of the disease, monitor the effectiveness of treatment, to identify complications. The normal body temperature of cattle is PR�Affairs from 37.5 to 39.5°C.

Heart rate (pulse) in cattle varies from 50 to 80 per minute. Depending on the pathological state may be rapid or slow pulse. Increased heart rate (tachycardia) notes during fever, collapse, heart failure, heart disease, acute myocarditis, anemia, etc. Increased heart rate is 2.5 times or more unfavorable prognostic sign. Slow pulse (bradycardia) often with colds, vagotonia, lowering the tone of the sympathetic nervous system, increased intracranial pressure, digitalis poisoning, uremia, toxemia, in the stage of convalescence after infectious diseases, exhaustion, diseases of the peritoneum and internal organs, etc.

NPV ranges in cattle from 12 to 25 per minute. The change in NPV is determined mainly by the level and intensity of metabolism, which in turn depends on species, age, breed, constitutional features of animals and their physiological state. Pathological change in the frequency of breathing is reflected in the increased frequency (tachypnea, polypnoea) or ischemia (oligopol). Shortness of breath is observed in diseases accompanied by fever, irritation of the respiratory center by toxins circulating in the body, while reducing the respiratory surface of the lungs (pneumonia, Gan�Wren, alveolar emphysema), with lesions of the blood system and blood (anemia, cardiovascular failure). Slowing of breathing may be due to inhibition of the respiratory center in functional and organic lesions of the brain, hypocalcemia, ketosis, intoxication, atonal condition.

Index Hildebrandt, calculated as the ratio of heart rate to respiratory rate per minute is a measure of the coherence of the heart and lungs [Saratovskaya N. In. A predictive model of individual health of senior pupils / N. In. Saratovskaya, A. S. Kalmykov, A. A. Khripunova // international journal of applied and fundamental research. - 2013. - No. 4. - S. 46-51].

IDN, calculated as the ratio of NPV per minute after 30 seconds artificial breath hold (apnea) during expiration to the NPV per minute at rest, allows to reveal hidden in calves respiratory failure and to evaluate the functional state of the respiratory system. In healthy calves IDN is 1.1-1.5, when a latent respiratory failure - more than 1.5.

The method is as follows.

In calves, bronchitis, measure body temperature, determine the heart rate and respiratory rate per minute, IDN, calculated as the ratio of NPV per minute after 30 seconds artificial breath hold (apnea) during expiration to the NPV per minute on�th, and index Hildebrandt, calculated as the ratio of heart rate to respiratory rate per minute.

At body temperature from 37.5 to 39.6°C, heart rate less than 100 / minute, respiratory rate less 40 per minute, the values of the Eden and more than 1.4 index of more than 1.8 Hildebrandt in calves the prognosis of bronchitis is favorable, that is, the expected full recovery of the animal or benign course of the disease.

At body temperature of more than 39.5°C, heart rate of 90 to 120 per minute, respiratory rate 40 to 60 per minute, the IDN values from 1.2 to 2.5 and index Hildebrandt from 1.7 to 3.1 in calves the prognosis of bronchitis questionable when not excluded unfavorable course of the disease.

At body temperature of more than 39.5°C, heart rate over 100 per minute, respiratory rate over 60 per minute, the IDN values less than 1.2 and index Hildebrandt less than 1.8 in calves the prognosis of bronchitis adverse, that is, the expected partial recovery of the animal or malignant disease.

The invention can be used for predicting the course of bronchitis in calves in large animal farms, and small farms, has essential value for definition of tactics of treatment and monitor the effectiveness of treatment of bronchitis in calves.

A method of predicting the course of bronchitis in calves is illustrated by examples.

Example No. 1

The rationale for the use of the method

The company Warniproduct" �boosmansbos area of the Voronezh region was chosen 170 calves of 0.5-1.5 months of age: 152 - with pathology of respiratory organs, with macrobranchium 108 calves, with macrobranchium 25 calves with bronchopneumonia 20 calves, and 18 clinically healthy animals. Calves measured body temperature, determined heart rate and respiratory rate per minute, IDN, calculated as the ratio of NPV per minute after 30 seconds artificial breath hold (apnea) during expiration to the NPV per minute at rest, and the index Hildebrandt, calculated as the ratio of heart rate to respiratory rate per minute. The results of these studies are presented in table 1.

From table 1 it is seen that microbrachia and bronchopneumonia body temperature of calves was higher, and when microbrachia did not differ significantly compared with clinically healthy animals. All calves with respiratory pathology in heart rate and respiratory rate were significantly higher than in clinically healthy animals. Depending on the severity of the disease (macrobranchium, microbranches, pneumonia) was significantly changed NPV. By Eden from clinically healthy animals statistically significantly different groups of patients with calves macrobranchium (IDN was higher by 57.1%, P < 0.05) and bronchopneumonia (IDN was lower by 28.6%, P < 0,05), index Hildebrandt - calves, patients macrobranchium (was lower than 30.3%, P < 0,05), and animals, patients with bronchopneumonia (below by 48.5%, P < 0,05). The combination of indicators - body temperature, emergency�, NPV, IDN and index Hildebrandt - allows not only to distinguish clinically healthy calves, but also to differentiate microbranches, microbranches and bronchopneumonia.

Example No. 2

Evaluation of the effectiveness of the method

The company Warniproduct" novousmansky area of the Voronezh region was selected 151 calf of 0.5-1.5 months of age with clinical diagnosis of bronchitis. For the animals within 10 days led constant clinical observation: measure the temperature of the body, determined heart rate and respiratory rate per minute, IDN, calculated as the ratio of NPV per minute after 30 seconds artificial breath hold (apnea) during expiration to the NPV per minute at rest, and the index Hildebrandt, calculated as the ratio of heart rate to respiratory rate per minute, take into account the condition of the visible mucous membranes, the sensitivity of the larynx, trachea and intercostal spaces on palpation, the presence and nature of wheezing, breathlessness, coughing, nasal expirations, evaluated the severity and outcome of the disease.

Depending on the clinical condition at the initial examination all the calves were divided into three groups. The first group included animals (n=64) body temperature from 37.5 to 39.6°C, heart rate less than 100 / minute, respiratory rate less 40 per minute, the values of the Eden and more than 1.4 index of more than 1.8 Hildebrandt. According to the claimed method the prognosis of bronchitis in calves of this group was favorable, expected p�lnoe recovery animals or benign course of the disease. The second group consisted of calves (n=49) with a body temperature of more than 39.5°C, heart rate of 90 to 120 per minute, respiratory rate 40 to 60 per minute, the IDN values from 1.2 to 2.5 and index Hildebrandt from 1.7 to 3.1. According to the claimed method the prognosis of bronchitis in animals of this group was questionable, do not rule out the unfavorable course of the disease. The third group consisted of calves (n=38) with a body temperature of more than 39.5°C, heart rate over 100 per minute, respiratory rate over 60 per minute, the IDN values less than 1.2 and index Hildebrandt less than 1.8. According to the claimed method the prognosis of bronchitis in animals of this group was unfavorable, it was expected partial recovery of the animal or malignant disease. The results of clinical observation of the calves is presented in table 2.

From table 2 it is seen that the calves of the first group with favorable prognosis bronchitis lung disease was noted in 100% of cases and in 25% of animals observed self-healing. In the second group with questionable prognosis bronchitis in 65.3% of calves were noted moderately severe disease, 34.7% of animals with severe complications of bronchopneumonia. In the third group with a poor prognosis bronchitis all calves were noted severe disease with complications of pneumonia.

From this example it is clear that the proposed method p�allows to objectively predict the course of bronchitis in calves and anticipate the complication of the disease in the form of bronchopneumonia.

Thus, the proposed method of predicting the course of bronchitis in calves the results of detection of body temperature, heart rate and respiratory rate per minute, IDN, calculated as the ratio of NPV per minute after 30 seconds artificial breath hold (apnea) during expiration to the NPV per minute at rest, and index Hildebrandt, calculated as the ratio of heart rate to respiratory rate per minute, has a high sensitivity, simplicity and reliability, reduces the cost and time involved in clinical and laboratory studies, can be used for predicting the course of bronchitis in large livestock complexes, and small farms, has essential value for definition of tactics of treatment and monitor the effectiveness of treatment of bronchitis in calves.

A method of predicting the course of bronchitis in calves, including determination of body temperature, heart rate (HR) and frequency of respiratory movements (NPV) per minute, the calculation of the index of respiratory failure (IDN) as the ratio of the frequency of respiratory movements per minute after 30 seconds artificial breath on the exhale to the frequency of respiratory movements per minute at rest, the calculation of the index Hildebrandt as the ratio of heart rate to respiratory rate per minute, data analysis and forecasting a full recovery animal�or benign course of the disease (favorable prognosis prognosis bona) at body temperature of 37.5÷39,6°C, heart rate less than 100 / minute, respiratory rate less 40 per minute, the values of the Eden and more than 1.4 index of more than 1.8 Hildebrandt, forecasting the possibility of an unfavorable course of illness (questionable prognosis, prognosis dubia) when the body temperature of more than 39.5°C, heart rate of 90÷120 per minute, respiratory rate 40 to 60 per minute, the values of the Eden 1,2÷2,5 and index Hildebrandt 1,7÷3,1, forecasting incomplete recovery of the animal or malignant course of the disease (poor prognosis, the prognosis mala) when the body temperature of more than 39.5°C, heart rate over 100 per minute, respiratory rate over 60 per minute, the IDN values less than 1.2 and index Hildebrandt less than 1.8.



 

Same patents:

FIELD: medicine.

SUBSTANCE: patient's epicardial fat thickness is measured by transthoracic echocardiography by means of a sector transducer at a frequency of 2,500 MHz on a free anterior wall of the right ventricle. Pulse Doppler imaging is performed to determine the diastolic function of the left ventricle - the E/A ratio measured as a transmitral blood flow velocity in the early diastolic filling of the left ventricle (E peak) to a transmitral blood flow velocity in a left auricular systole (A peak). If the epicardial fat thickness is from 2.7 to 4.5 mm, whereas the E/A diastolic function is less than 0.80, insulin resistance is diagnosed.

EFFECT: higher diagnostic accuracy, as well as wider number of individuals, who had the insulin resistance diagnosis.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment, namely to means for performing cardio-pulmonary resuscitation of people. Device for control of cardio-pulmonary resuscitation contains ultrasound converter, unit of electrodes, connected via interface to processor, connected with display, memory unit, sound signaller, unit of light-diode signallers, unit of connection with central control panel unit of operation mode selection, unit of connection with the internet and, via USB interface, with unit of top level software. Device also contains colour television microcamera, connected via successively installed block of signal amplification and filtration and unit of processing and imposing alignment of images to additional processor input/output, illumination unit, pulse measurement unit, gas analyser, unit of microphones with matching unit, connected with processor and power supply unit. Pulse measurement unit and unit of electrodes are made with possibility of fixation on patient by means of fixation unit, with unit of microphones, controlled illumination unit and gas analyser being fixed on patient by means of additional fixation unit. Method of control contains stages of obtaining ultrasound echo signals and electrosignals, characterising blood flow in blood vessel, determination of blood flow characteristic by impedance of neck tissues in the process of performing cardio-pulmonary resuscitation, presentation of sound and visual information about patient/s condition. After that, current information about patient's condition is formed by television images and geometrical and colour characteristics of eye pupil and eye iris are determined, with estimation of colour and geometrical characteristics of blood vessels. Sound laryngeal signals, exhaled gas and patient's pulse are also read and analysed, light signals are used to signal about patient/s condition and patients condition is estimated basing on data of comparison of standard and current information.

EFFECT: application of invention makes it possible to extend functional possibilities, increase operation speed, immediacy and accuracy in performing cardiopulmonary resuscitation.

16 cl, 10 dwg

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. A method for detecting individual's respiration and/or cardiac function is implemented by means of movement detection. A multiaxial accelerometer is placed on the individual's body. The accelerometer generates signals indicating the acceleration along separate spatial axes. A signal generation unit is used to generate a movement signal by linear combination of the accelerometer signals along the separate spatial axes. The movement signal indicates the individual's respiration and/or cardiac function. The accelerometer signals are weighed so that the accelerometer signal characterised by the maximum acceleration variation has the highest weight. The movement signal generation unit detects the accelerometer signal weight depending on correlation of the respective accelerometer signal and the accelerometer signal characterised by the maximum acceleration variation. The respective accelerometer signal weight is a correlation sign.

EFFECT: using the group of inventions enables increasing the movement signal quality having a high signal/noise ratio.

11 cl, 8 dwg

FIELD: medicine.

SUBSTANCE: parasympathetic chain of the vegetative nervous system is activated by developing diaphragm pattern of breathing with preset inspiration-expiration ratio 1:4 by means of voice commands. The inspiration and expiration length is controlled under the control of cardiac rhythm. The total length of a training session makes from 5 to 7 minutes daily.

EFFECT: method enables reducing a risk of myopia that is ensured by stabilising the vegetative balance.

2 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: age and body weight index (BWI) are determined with the following clinical signs taken into account: shortness of breath, tachypnea, tachycardia, symptoms of deep vein thrombosis, thoracic X-ray findings, blood serum D-dimer and interleukin-6; each sign is appraised by points. The appraised points are summed up; the total score is used to calculate a probability of grouping a patient as having low and high probability of thromboembolia of the pulmonary artery.

EFFECT: method enables providing more accurate and informative determination of the clinical probability of thromboembolia of the pulmonary artery by antropometric and clinical studies.

2 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: patient's monitor comprising: EEG recorder (14, 20) controlling patient's (10) electrocardiographic signal (40); a secondary physiological signal monitor (16, 20) controlling a second patient's physiological signal (50) simultaneously with the EEG recorder controlling patient's electrocardiographic signal; an a alarm detector (42, 44) configured to detect the alarm on the basis of the patient's electrocardiographic signal; alarm verification device (52, 54, 56) configured to verify the alarm on the basis of pulse component regular pattern of the simultaneously controlled second patient's physiological signal; and an alarm indicator (24, 26, 58) configured to generate the perceived alarm by the alarm detector and to verify the alarm by the alarm verification device.

EFFECT: alarm verification.

12 cl, 5 dwg

FIELD: medicine.

SUBSTANCE: method involves immersing in a decompression chamber at a depth of 30 metres, staying at this depth for 1 hour and decompressing for 63 minutes. The following values are determined 30 minutes before the immersion: systolic blood pressure (SBPbi), heart rate (HR) and moving object response (MOR). The following values are determined 30 minutes after the immersion in the decompression chamber: systolic blood pressure (SBPai) and critical flicker fusion frequency (CFFF). That is followed by determining an index of persistence to decompression disease (DD) in the females aged 30-40 (IPDDF30-40) by formula: IPDDF30-40=0.442+0.032×SBPbi+0.017×SBPai-0.032×HR-0.009×MOR-0.017×CFFF-0.048×age, wherein SBPbi is the systolic blood pressure measured before the immersion, mm Hg; SBPai is the systolic blood pressure measured after the immersion, mm Hg; HR is the heart rate measured before the immersion, beats per minute; MOR is the moving object response measured before the immersion, ms; CFFF is the critical flicker fusion frequency measured after the immersion, Hz; age is the age, completed years. If IPDDF30-40 is 1.1 included, the high persistence to DD is stated in the female; the value falling within the range of 1.1 to 2.19 included shows the moderate persistence to DD is stated; and if the value of more than 2.19, the low persistence to DD is shown.

EFFECT: method provides the differentiated assessment of the persistence to DD in the females of certain age with using no additional equipment.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to preventive medicine, and aims at detecting young individuals suffering from a high risk of cardiovascular diseases for the timely correction. The individuals are presented with a questionnaire to detect major risk factors of the cardiovascular diseases in accordance with the National Cardiovascular Disease Prevention Guidelines. The questionnaire results are appraised by points: if observing psychological stress 3.01-4 for males and 2.83-4 for females, 0 points are assigned; 2.01-3 for males and 1.83-2.82 for females, 1 point is assigned; 2 and less for males and 1.82 and less for females, 2 points are assigned; if the respondent doesn't smoke, 0 points are assigned; if he/she smokes less than 1 cigarette a day, 1 point is assigned; smoking 1 and more cigarettes a day implies assigning 2 points; if the patient intakes ethanol in an amount of 13.7 g a day and less, 0 points are assigned; an intake of ethanol in an amount of 13.8 g to 27.4 g a day and less enables assigning 1 point; using ethanol 27.5 g and more requires assigning 2 points; if blood pressure is less than 129/84 mm Hg, 0 point is assigned; if the blood pressure value falls within the range of 130-139/85-89 mm Hg, 1 point is assigned, and 2 points are assigned, if the blood pressure value is 140/90 mm Hg or more; if a body weight index is 24.9 kg/m2 and less, 0 points are assigned; if the range is 25-29.9 kg/m2, 1 point is assigned; the value of 30 kg/m2 provides assigning 2 points; if the physical activity is accompanied by energy burning of 3 MET/min and more over six late months and more, 0 points are assigned; the physical activity accompanied by energy burning of 3 MET/min under six late months, 1 point is assigned; if the physical activity is accompanied by energy burning of less than 3 MET/min, 2 points are assigned; if the individual consumes more than 500 g of vegetables and fruit a day, 0 point is assigned; consuming less than 500 g provides assigning 1 point, and if a daily ratio contains no fruit and vegetables, 2 points are assigned; if a rest heart rate is 50 to 69 beats per minute, 0 points are assigned; the heart rate falling within the range of 70 to 79 beats per minute provides assigning 1 point, and the heart rate of 80 beats per minute and more ensures assigning 2 points; a negative past medical history of the cardiovascular diseases with manifested ischemic heart disease or cardiovascular diseases in the male relatives in the first degree aged 55 years old or less and in the female relatives in the first degree aged 65 years old or less shows assigning 0 point, while a positive past medical history of the cardiovascular diseases makes it possible to assign 1 point. The total score is derived, and if the calculated value is 8 points and more, the respondent is referred to a group of a high risk of cardiovascular diseases, and preventive measures are recommended.

EFFECT: method enables evaluating a risk of cardiovascular diseases in the young individuals by evaluating the risk factors.

1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, forensic medicine, diagnostic measurements, including in investigative practice. An interactive psychophysiological testing (PPT) involves presenting a person being tested test questions, determining, analysing the psychogenesis parameters with using the person's physical parameter sensors, indicating the results and estimating. The test questions are typed as follows: first-version questions Q1, second-version questions Q2, neutral questions N. The questions Q1 and Q2 have an alternative meaning and equal power and are characterised by an equal presentation time, a consistency of comparing the questions according to the alternative versions, a minimised subjective personal effect of the PPT test expert by sound colour and level, an unconscious emotional support on the person's question perception, as well as an identity of putting the questions to be compared, their length and a fixation of the meaningful word and/or word combination in similar segments of both questions to be compared. The test is put in accordance with a concatenation as follows X:0→C,…,C→Q11.Q21→N→ →Q21.Q22→N→…→Q1n.Q2n→N, wherein X is a person's identification index; 0 is a non-estimated zero question; C is a question relieving an expectation stress; Q1i is the first-version question, wherein i=1, 2,…, n; Q2i is the second-version question, wherein i=1, 2,…, n; N is a neutral question; n is a number of specific circumstances of the event or action; ":", "→", "." are devisors. The questions are put taking into account the staging of the tested event, including the confirmed facts or data only and excluding the expert's conjectures or versions. The results are used to state one of the two alternative versions and to estimate the respective status of the person being tested. The psychogenesis is determined and analysed with using a polygraph, while putting the questions of the two alternative versions, indicating and processing the PPT data are conducted with a computer with relevant software.

EFFECT: method provides higher information value, accuracy, reliability, objectiveness of the PPT results as compared to the previously known tests up to 90-95% with avoiding the distortion and ambivalence of the results.

5 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to agents for non-contact respiratory monitoring. A method for detecting a patient's expiration to inspiration variations or vice versa involving the stages of emitting an electromagnetic signal towards the patient and receiving the signal reflected from the patient, transforming the reflected signal to produce the first signal, dephasing the reflected electromagnetic signal and transforming it to produce the second signal, using a computing unit to detect simultaneous first zero transients in a time derivative of the first signal and in a time derivative of the second signal, simultaneous second zero transients in the time derivative of the first signal and in the time derivative of the second signal, and simultaneous third zero transients in the time derivative of the first signal and in the time derivative of the second signal, determining the first and second vectors and calculating their scalar product as an indicator value for the patient's expiration to inspiration variations or vice versa comparing the indicator value to the pre-set threshold value and specifying the patient's expiration to inspiration variations or vice versa, if the indicator value is less than the threshold value. A device for implementing the method involves a two-channel Doppler radar sensor and the computing unit.

EFFECT: using the invention enables providing more accurate measurement and detection of the respiratory rate.

6 cl, 6 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to vascular and endovascular surgery, and can be used to assess the state of an isolated aneurismal sac after a stent graft implantation by measuring a pressure inside the sac, as well as for introducing drugs into the blood vessel aneurism as it may be required. The device for pressure measurement in the isolated cavity of the aneurismal sac and for drug introduction into the blood vessel aneurism is configured as a hollow tube. The tube has side holes and is configured to reshape when inserted into the aneurism, to fill its inner space circumferentially, to attach by a two-piece hollow tube to a pressure sensor to measure a pressure between the vascular wall and the wall of the stent graft implanted into the blood vessel, as well as to introduce drugs by means of the above two-piece hollow tube. The tube is made of a viscoelastic absorbable material and spiral-shaped.

EFFECT: invention enables solving a set of challenges: saving the manufacturing expenses, simplifying the course of the surgical intervention, measuring the pressure, introducing the drugs, improving the immediate and remote results by ensured thrombosing of the aneurismal sac.

5 cl, 3 dwg

FIELD: chemistry.

SUBSTANCE: invention refers to medicine, namely surgery, and can be used for treating aseptic pancreonecrosis. Intra-organic pulseless pancreatic segments are localised and removed. To cover the pancreas, a greater omentum is incised into two portions - 1/3 from the left and 2/3 from the right up to a base of the greater omentum. Segments with pulse oscillation amplitude not less than 3.0 mm in the left 1/3 of the greater omentum and not less than 2.0 mm in the right 2/3 of the greater omentum are localised. The left portion in the distal segment is anchored with U-sutures to peripancreatic subcutaneous fat, whereas the right portion in the distal segment is anchored to a right hepatic lobe.

EFFECT: method enables arresting the disease progression and preventing infected pancreatic necrosis, improving pancreatic tissue blood supply by detecting the intra-organic pulse, removing all necrotic portions of the pancreas and using the greater omentum to cover the pancreas.

3 dwg, 2 ex

FIELD: physics, computer engineering.

SUBSTANCE: group of inventions relates to ergatic systems and can be used to correct the functional status of a human operator. The method includes evaluating the status of a human operator. The status indicator used is the heart rate. Limiting values of the range of a good status ChSSmin and ChSSmax are set for each human operator. When the heart rate exceeds the limiting values, the energy stimuli used are light pulses and binaural action, the frequency f of which is set in accordance with a given expression. An apparatus for correcting the functional status of a human operator is used. The apparatus comprises a central control unit connected to a storage unit, a stimulus generating unit and an analysis unit. The stimulus generating unit is connected to a stimulation unit. The output of the analysis unit is connected to the central control unit. The apparatus additionally includes a unit for measuring and processing an electrical cardio signal and a heart rate determining unit. The output of the unit for measuring and processing an electrical cardio signal is connected to the input of the heart rate determining unit, the output of which is connected to the analysis unit.

EFFECT: group of inventions improves the efficiency of correcting the status of a human operator, prevents excessive fatigue of the human operator quickly and in advance, reduces emotional and psychological stress, raises the level of activity of the body owing to a method of determining the status of the human operator, using the heart rate ChSS as an indicator of the status, the effect of light stimuli and binaural action.

2 cl, 2 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: clinical, X-ray and echocardiographic examinations are performed in a premature infant on the third day of life. Gestation age, Apgar score, infant's reflexes, states of the muscular system, skin, oedemas, moist rale, increased pulmonary vascularity on the X-ray pattern, as well as echocardiographic values of final diastolic size, left atrium and right ventricle per one kilogram of infant's body weight are assessed, and a prognostic coefficient is determined by mathematical formula. If the prognostic coefficient is 10 points and more, the high risk of long persistence of a haemodynamically significant form of the open arterial duct in the premature infants is predicted; the prognostic coefficient falling within the range of 0 to 9 points shows the low risk of long persistence of the haemodynamically significant form of the open arterial duct.

EFFECT: method enables predicting the non-invasive prediction of the high risk of long persistence of the haemodynamically significant form of the open arterial duct in the premature infants on the third day of life, and specifying the further therapeutic approach to the infant and the absolute indications for persistent foetal communication correction.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiosurgery. The bypass blood flow is assessed with assisting artificial circulation and clamped aorta. After a distal anastomosis is created, the bypass is connected to a heart and lung apparatus by means of an intravenous infusion system. Each anastomosis is assessed successively.

EFFECT: method enables the intraoperative assessment of the blood flow in the bypasses and the inspection of the dysfunctional anastomosis before unclamping the aorta and applying cardioplegic solution additionally.

3 dwg

FIELD: medicine.

SUBSTANCE: group of inventions relates to medical diagnostics. Method of determining degree of vessel narrowing contains stages at which obtained are: sequence of first pressure measurements P1 and sequence of respective first rate measurements U1 in first location inside vessel, sequence of second pressure measurements P2 and sequence of respective second rate measurements U2 in second location inside vessel. Wave rate c in fluid medium is determined for each location depending on square of pressure change divided by square of respective rate change. For first location change of direct pressure is determined depending on the sum of pressure change and rate change. For second location change of direct pressure is determined depending on the sum of pressure change and rate change. Reserve of separated direct flow, representing drop of pressure through target area is determined, with said drop of pressure indicating degree of local narrowing or compression of vessel between said first location and second location. Device for determining degree of vessel narrowing is described.

EFFECT: inventions provide measurement of localised flow restriction.

14 cl, 6 dwg

FIELD: medicine.

SUBSTANCE: patient with premature atrial contraction (PAC) undergoes ECG study. A signal-averaged ECG is recorded. The method involves measuring the length of a filtered push-pull (FiP-P) wave of the signal-averaged ECG (ms), P wave dispersion determined as a difference of maximum and minimum P wave lengths while recording 12 leads of the standard ECG (Pd) (ms), a linear deviation (A), B that is the number of premature atrial contractions per hour, a risk index of developing atrial fibrillations (RIDAF) by an original formula. If the RIDAF is less than 0.5, the high risk of atrial fibrillation is predicted for 1-3 months; the RIDAF from 0.5 to 1.5 stands for the moderate risk during 3 months to 1 year, whereas the RIDAF of more than 1.5 shows the low risk for more than 1 year from the first examination of the patient suffering from premature atrial contraction.

EFFECT: method enables increasing the determination accuracy of the risk of atrial fibrillation following the first examination and correcting the therapy.

3 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: method involves determining a period of time from the onset of symptoms to establishing a diagnosis (t); a functional class is rated at the time of establishing the diagnosis (FCinit); a cardiac output is calculated at the time of establishing the diagnosis (CO); an acute pharmacological test (APT) coefficient (X) is calculated as follows: (APT-)=0, (APT+)=1, (APT++)=2. A risk of the unfavourable clinical outcome in the patients suffering from idiopathic pulmonary hypertension (H) is calculated by an original formula. If the value H ≤0.35, a low risk is stated; H=0.36-0.55 shows a moderate risk, whereas H≥0.56 is a sign of a high risk of the unfavourable clinical outcome.

EFFECT: method enables the high-reliability detection of the unfavourable clinical outcome in the patients with idiopathic pulmonary hypertension, the determination of rates of the disease progression for the purpose of prescribing an adequate therapy.

2 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medical equipment. A cuff contains a chamber for the application of pressure to the area of measurement; a screwable element for displacement of a chamber (161) for a flowing medium to the area of measurement, and a chamber-like covering element, which includes the chamber of the flowing medium and the screwable element and is configured in the form of a tape, wrapped around the area of measurement. The screwable element has a curved shape, which follows the direction, in which the screwable element is wrapped around the area of measurement, and has two curvilinear regions and a rectilinear connecting region, which connects the said curvilinear regions in the section in the points of bending, in which the radius of the screwable element curvature changes. The connecting region is located inside the curve, formed by the extension of the curvilinear regions. The central position between the first point of bending in the section and the second point of bending in the section is superposed on the central position of the chamber for the flowing medium in the direction, in which the chamber for the flowing medium is wrapped around the area of measurement. Versions of implementation of the device for pressure measurement and an additional version of the cuff are disclosed.

EFFECT: group of inventions makes it possible to reduce the measurement error due to the reduction of errors of the chamber volume change.

6 cl, 15 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to occupational medicine, and can be used for specifying the indications for the instant correction of the psychophysiological states. A cardiointervalogram is recorded before and after professional activity. A range of RR interval lengths (MxDMnbefore, MxDMnafter), a square root of a total difference of a sequence of RR intervals (RMSSDbefore, RMSSDafter) and a mode amplitude of RR interval lengths (AMobefore, AMoafter) are determined. Differentiation functions G1 and G2 are calculated. If G1 is less than G2, the individuals being tested are considered to be in need of the instant correction of their psychophysiological states. Otherwise, it is stated that the individuals being tested are not in need of the instant correction of their psychophysiological states.

EFFECT: examining the individual before and after the occupational activity, using the cardiointervalography findings and specifying the most significant criteria for the psychophysiological states assessment make the method increase the responsiveness to the process of detection if there are any individual-specific indications for the instant correction of the psychophysiological states.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used for the infrared visualisation of foreign matters in a hand. The hand is exposed, and the arm is circularly compressed above the hand until arterial pulse disappears on the periphery. The hand is immersed in water at temperature +25 - +26°C for 3-10 seconds. The hand is taken out from water and placed with its desired plane onto a flat persistent heat emitter at temperature +42°C made of a high-thermal conductivity material. The hand is fixed in a position to perform the infrared visualisation of a surface opposite the hand plane by means of a thermal imaging device. That is followed by recording a local temperature flow of this ischemic plane. What is used is a thermal imaging device having capable to image the examined surface on a display in red to purple colours depending on its local temperature within the range of +26 - +37°C respectively. If the hand appears to have abnormal local hypo- or hyperthermia, its zone is shaped, sized and localised. If the abnormal hypo- or hyperthermia zone is absent, the examination is repeated not earlier than 5 minutes later by changing a sequence of using the hand planes.

EFFECT: method provides more effective, safe and accurate detection of the foreign matters, including for performing sparing surgical operations on dry hand, with eliminating high blood loss.

1 ex

Up!