Incapsulated in gelatine composition for oral cavity care, containing active substances for dental occlusion, hydrophobic modifier of viscosity and oily carrier

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and is intended for oral cavity care. Compositions contain: a) guanidine-based active substance, b) film-forming polymer, c) hydrophobic modifier of viscosity in quantity, sufficient for provision of composition for oral cavity care with time particle sedimentation more than 20 minutes, and d) oil carrier. Guanidine-based active substance preferably represents L-arginine. Film-forming polymer preferably represented GANTREZ. Hydrophobic modifier of viscosity preferably represents thickened mineral oil. Oil carrier preferably represents natural oil. Composition is enclosed in gelatine capsule. Method of teeth cleaning includes application on teeth of composition for oral cavity care in such a way that composition for oral cavity care cleans teeth. Device for oral cavity care, which contains: handle, fastened on handle head, where head has external surface and a row of teeth-cleaning elements, projecting outwards on external surface, and gelatine capsule, which contains composition for oral cavity care, located on head.

EFFECT: group of inventions makes it possible to increase teeth cleaning efficiency.

14 cl, 2 ex, 1 tbl

 

The technical field to which the invention relates

The invention relates to encapsulated compositions for the care of mouth cavity containing devices to care for the oral cavity.

Prior art

In the application PCT/US2010/039677 describes the use of arginine and containing a film of a polymer of methyl vinyl ether/maleic anhydride (GANTREZ S™) in a liquid for rinsing of a mouth for receiving visokoaktivniy film, which is effective for occlusion of the dentinal tubules, and thus reduces the sensitivity of teeth.

Other publications that describe the use of arginine and GANTREZ in a composition for caring for the oral cavity include US 20090202456 A1, US 20090311200 A1 and US 20100135932 A1.

Despite the above developments, it is desirable to provide funds for the occlusion of dentinal tubules in encapsulated in gelatin liquid compositions for caring for the oral cavity. In addition, it is desirable to provide equipment for the care of mouth cavity containing gelatin capsules containing means for the occlusion of the dentinal tubules.

Brief description of the invention

Described in the present description of the various implementation options satisfy the above needs by providing an encapsulated in gelatin liquid compositions for the care of the cavity� mouth, containing means for the occlusion of the dentinal tubules, and containing devices to care for the oral cavity.

According to one aspect of the invention, the composition for caring for the oral cavity contains the: a) active substance on the basis of guanidine, (b) film-forming polymer, c) a hydrophobic viscosity modifier in an amount sufficient to provide compositions for caring for the oral cavity over time, the deposition of particles larger than 20 minutes, and (d) an oil carrier.

In certain embodiments, the composition for caring for the oral cavity is encapsulated in a capsule containing gelatin.

In certain embodiments, the active substance on the basis of guanidine is contained in a quantity effective to reduce hypersensitivity of the teeth.

In certain embodiments, the active substance on the basis of guanidine is 1-10 wt%. compositions for caring for the oral cavity.

In certain embodiments, the active substance on the basis of guanidine is a L-arginine.

In certain embodiments, the film-forming polymer is 1-5 wt%. compositions for caring for the oral cavity.

In certain embodiments, the film-forming polymer is a copolymer of methyl vinyl ether and maleic anhydride.

In certain variations�tah implementation hydrophobic viscosity modifier is more than 4% of the mass. compositions for caring for the oral cavity.

In certain embodiments, the hydrophobic viscosity modifier contains a gelled mineral oil. In certain such embodiments, gelled mineral oil is plastigel containing a polyethylene and mineral oil.

In certain embodiments, the oil carrier is 60 to 80% of the mass. compositions for caring for the oral cavity.

In certain embodiments, the oil carrier comprises at least one vegetable oil and silicone oil.

In certain embodiments, the oil carrier includes C6-C12-triglyceride.

In certain embodiments, the composition for caring for the oral cavity further comprises 5-25 wt%. flavour and 0.1-5 wt%. sweetener.

In certain embodiments, the composition for caring for the oral cavity further comprises at least one member selected from the group consisting of abrasives, antibacterial agents, foam-forming means, a bleaching agent, anti-plaque, anti-calculus, anti-inflammatories, anticaries funds, flavouring agent, sweetener and colorant.

In certain embodiments, active� substance on the basis of guanidine represents L-arginine, the hydrophobic viscosity modifier is a gelled mineral oil, film-forming polymer is a copolymer of methyl vinyl ether and maleic anhydride, and the oil carrier is a Caprylic/capric triglyceride, and a composition for caring for the oral cavity further comprises hydrated silica, sorbitol, energy, glycerin, colorant and flavoring.

In certain embodiments, the viscosity of the composition to care for the oral cavity is 300 to 800 SP.

According to another aspect of the invention a method of cleaning teeth comprises applying to the teeth a composition for caring for the oral cavity according to the invention so that the composition is to care for the oral cavity cleans teeth.

According to one another aspect of the invention, the fixture to care for the oral cavity that contains: handle, mounted on the knob head, where the head contains the outer surface and a number of cleaning teeth element projecting outward on the outer surface, and a gelatin capsule containing a composition for caring for the oral cavity according to the invention, located on the head.

Detailed description of the invention

As used throughout, ranges are used as a shorthand for describing each and every value that is included in the range. Any value�tion in the range can be selected as the final value of the range. In addition, all cited throughout the present description reference is fully included, therefore, by reference. In case of discrepancies in the description in the present description and the description of the cited references present description has the advantage. In addition, the compositions and methods may include, essentially consist of or consist of the elements described in the present description.

Unless otherwise indicated, all percentages and quantities specified in the present description and in the description, should be understood as referring to mass percent. Given the amount determined in the calculation of the active mass of the substance. The enumeration of particular value in the present description is intended to indicate the value, plus or minus the degree of variability due to measurement errors. For example, the amount of 10% may include a 9.5% or 10.5%, giving a margin of error of measurement, which will take into account and understand the specialists in this field.

As used in the present description, the terms "treatment" or "treating" are intended to include prophylaxis. The terms include the improvement, the prevention and relief of symptoms and/or effects associated with hypersensitivity of the teeth. The terms "preventing" or "prevention" refer to the preliminary introduction of a composition for the prevention�moving or blunting hypersensitive teeth. Specialists in this field of compositions for the treatment of hypersensitive teeth (which addressed the claims on the real way) understand that the term "prevent" is not an absolute term. On the contrary, it should be understood that the term refers to a prophylactic to the introduction of the composition to reduce the likelihood or severity of condition, and this is the intended meaning.

"Orally acceptable amount" of a compound is an amount which is not harmful to a mammal, when containing such a quantity of the composition is kept in the mouth, not swallowing, during the period of time that is sufficient to allow deposition on the surface of the oral cavity, as provided in the present description. Basically this number of connections is not dangerous, even if the song unintentionally swallow. "Orally acceptable carrier" means any medium or media that is not harmful to a mammal, when the carrier used in the composition, which is held in the mouth, not swallowing.

Composed of a composition for caring for the oral cavity, such as toothpastes and gels contain a number of functional and active ingredients, each of which provides at least one desirable property. Accordingly SOS�awinnie composition for caring for the oral cavity are suitable for regular use to maintain a healthy state of the oral cavity. Functional additives include foam-forming means which is dispersed other ingredients and ensure the delivery of active and functional substances on the surface of the oral cavity, and means against the formation of Tartar to prevent the formation of Tartar on the tooth surfaces, as well as aesthetic and functional ingredients, such as flavouring agents and pigments. Active ingredients include anticaries tools that provide a source of fluoride ion when you use. Various compositions also contain compounds or components with antibacterial properties, for example, to reduce the formation of plaque on the surfaces. Additional active ingredients include ingredients with anti-inflammatory properties for the prevention and treatment of conditions, such as gingivitis.

Throughout the description, the expression "active substance to care for the oral cavity" means a component that provides an active force in the process of care for the oral cavity. Active substances for the care of the oral cavity include, but are not limited to, foaming tools, antibacterial agents, whitening agents, anti-plaque, anti-microbial agents, anti-dental plaque formation, anti - �DIY tools, etc.

The invention is partially justified by the desire to provide non-aqueous liquid composition for caring for the oral cavity containing an active substance effective for treating or preventing hypersensitivity of the teeth. Although it is known that arginine and GANTREZ suitable for treating or preventing hypersensitivity of the teeth, when they are dissolved in a composition for caring for the oral cavity, unexpected was the fact that arginine and GANTREZ suspended (undissolved) in an oil carrier, provide highly efficient occlusion of the tubules.

Also unexpected was the fact that the hydrophilic active substances, such as arginine and GANTREZ entered in the Central core on the basis of vegetable oil softgels, cause instability cosmetics, as well as the delivery problem. Without wanting to be bound by any theory, it is believed that the problems caused by rapid migration of hydrophilic active substances in a gelatin capsule during the cooling phase, upon receipt, when all layers of the capsule are in fact liquid. This migration causes defects such as "fish eyes" in the capsules, presumably due to impaired structure of gelatin. In addition, the number of delivered hydrophilic active substance is difficult, because at least some of it (probably about 90% is constantly associated with gelatinous capsule and is not released or dissolved during the cleaning process.

The invention is based in part on the discovery that inactivation of hydrophilic active agents encapsulated in gelatin compositions for the care of the oral cavity, and the stability of the gelatin capsule, can prevent, reduce or slow down through the hydrophilic suspending the active substance in an oil carrier containing the hydrophobic viscosity modifier, and then introducing the resulting carrier oil and suspended hydrophilic active substances in a gelatin capsule.

The hydrophobic viscosity modifier of the composition to care for the oral cavity according to the present invention is, as the name implies, a hydrophobic ingredient, which increases the viscosity of the hydrophobic liquid. Gelled mineral oil currently represents the most preferred examples of suitable hydrophobic viscosity modifier. Gelled mineral oil preferably is a mixture of mineral oil and polyethylene, and most preferably plastigel 5, which is a mixture of 5% polyethylene in mineral oil and is available from Pharmaceutical Resources/Lyne Laboratories Inc. of Brockton, MA. Other suitable plastigel you can get ways Thau et al., "A New Procedure for the Preparation of Polyethylene-Mineral Oil Gels", J. Soc. Cosmetic Chemists, 16, 359-363 (1965). Suitable �hydrophobia viscosity modifiers, additional to gelled mineral oils, such as plastigel, can be determined using this description as a guide.

In addition to the hydrophobic viscosity modifier composition for caring for the oral cavity contains an oil carrier, such as vegetable oil and/or silicone oil. The oil carrier is preferably 50-90 wt.%, more preferably 60-80 wt%. and most preferably about 75% of the mass. composition. Medium chain triglycerides (MCT) are preferred as a carrier oil. Typically, the length of the chain MCT is from about 6 to about 12 carbon atoms. MCT can be a vegetable oil. Caprylic/capric triglyceride is a non-limiting example preferred for use in the invention MCT.

Hydrophilic active substance, preferably of 0.0001-20 wt.% or 0.1-15% wt., or 1-10% of the mass. compositions for caring for the oral cavity. Hydrophilic active substance preferably is an active substance on the basis of guanidine and/or film-forming polymer.

Active substance based on the guanidine is a compound containing a guanidine group, capable of forming ion guanidine in the conditions presented in the oral strips�I. Suitable active substances on the basis of guanidine include, but are not limited to, bicarbonate arginine hydroxide, arginine, arginine carbonate, arginine phosphate, organic phosphate arginine, arginine phytate, analogues aminoguanidine and aminoguanidine. L-arginine is particularly preferred.

Active substance based on the guanidine is provided in an amount effective to reduce hypersensitivity of the teeth, and preferably is 0.1-15% wt. or 1-10 wt.%, or 3-7% of the mass. compositions for caring for the oral cavity.

Film-forming polymer is preferably a synthetic anionic PCE. Anionic polycarboxylate mainly used in the form of their free acids or preferably partially or more preferably fully neutralized water soluble alkali metal salts (e.g. potassium and preferably sodium) or ammonium. Preferred film-forming polymers are copolymers of 1:4 to 4:1 of maleic anhydride or acid with another polymerizable ethyleneamines monomer, preferably methyl vinyl ether (methoxyethanol) with a molecular weight (M. M.) from about 30000 to about 1000000.

A particularly preferred film-forming polymer is a synthetic �polymer, contains poly(methyl vinyl ether/maleic acid). In another embodiment of the copolymer contains Palmyra poly(methyl vinyl ether/maleic acid). In another embodiment of the copolymer contains blended salts of poly(methyl vinyl ether/maleic acid).

It is possible to use polymers of any molecular weight, including, for example, of molecular weight from 50000 to 500000, 500000 to 2500000 or from 2500000 to 10,000,000 (calculated as the or bulk). In a preferred embodiment of the molecular weight of the copolymer is 130000. In one of the embodiments of the molecular weight of the polymer is 200000. In one of the embodiments of the molecular weight of the copolymer is 690000. In one of the embodiments of the molecular weight of the copolymer is 1000000. In one of the embodiments of the molecular weight of the copolymer is 1250000. In one of the embodiments of the molecular weight of the copolymer is 1980000. In another embodiment of the molecular weight of the copolymer is 2500000. In yet another embodiment of the molecular weight of the copolymer is 5000000.

Examples of such copolymers are available from ISP Corporation under the trade name GANTREZ, e.g. GANTREZ AN 139 (M. M. 1100000), GANTREZ AN 119 (M. M. 200,000), GANTREZ S-97 pharmaceutical product category�and (M. M. 1500000), GANTREZ AN 169 (M. M. 2000000) and GANTREZ AN 179 (M. M. 2400000), where the preferred copolymer is a GANTREZ S-97 pharmaceutical grade (M. M. 1500000).

Film-forming polymer is provided in amounts effective to reduce hypersensitivity of the teeth, and preferably is 0.1-10 wt%. or 1-5% of the mass. compositions for caring for the oral cavity.

In addition to the hydrophilic active substance, the hydrophobic viscosity modifier and oil carrier composition for caring for the oral cavity may further comprise one or more orally acceptable abrasive substances, flavors, colors, sweeteners, processing AIDS, and optionally water.

In certain embodiments, the composition for caring for the oral cavity contains, essentially consists of or consists of from 1 to 10 wt.%, preferably from 2.5 to 7 wt%. and most preferably 5 wt%. abrasives with a high cleansing effect, so that the total amount of abrasive delivered when applied, ranges from 2 mg to 8 mg, preferably 3 mg to 6 mg, and most preferably about 4 mg abrasives. Abrasive a substance with a high cleaning effect is contained in the orally acceptable carrier. A small amount of abrasives with small size�Ohm particles provides an improved effect on stain removal.

Preferably the abrasive is a substance selected from silicon dioxide with a high cleaning effect of tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP) and their mixtures. Typically, the average particle size of the abrasive is in the range from 2 to 18 microns with at least 90 mass% of particles with size less than 20 microns, determined by the abrasion radioactive dentin (RDA) in aqueous suspensions of silica powder is from 90 to 230, the efficiency of plaque removal (PCR) with the introduction of the composition to the teeth in a 10% by mass is more than 80, where the ratio of PCR to RDA is in the range from 0.4:1 to less than 1:1, and the value of the degree of abrasion plastic (PAV) is in the range from 1 to 20.

Preferred abrasives are silica, in particular with an effective cleaning capacity, which shows a relatively high PCR values detected during the conventional RDA values in a composition for caring for the oral cavity containing a relatively small amount of silicon dioxide. Although the ratio of PCR to RDA is less than 1, preferably, the RDA value is higher than that of the conventional silica with a higher ratio of PCR to RDA, and when comparing these products receive a higher value of PCR with the same amount of silicon dioxide. The values of abrasion plastic yavlyayutsya amount of scratching, produced on the surface of silicon dioxide and, thus, indicate possible damage to the teeth. Suitable silica have an average PAV, but high PCR, which indicates a good cleaning without excessive damage.

Suitable amorphous silica preferably have an oil absorption with the use of linseed oil in the range from 70 to 150 cm3/100 g, and more preferably, the oil absorption is in the range from 75 to 130 cm3/100 g. Also, the amorphous silica preferably has a specific surface according to BET in the range from 10 to 450 m2g-1and more preferably the specific surface according to BET is in the range from 50 to 300 m2g-1.

Mass average particle size of silicon dioxide can be determined using a Malvern Mastersizer™, and the preferred substance may have a mass average particle size in the range of 5 to 10 microns. The distribution of particle size and, thus, the proportion of particles with size less than any particular value can be determined in a similar way. For amorphous silica particle size at least 90% of particles by mass, preferably less than 17 microns.

In a particular embodiment of the mass average particle size of abrasives, suitable in embodiments, is dia�the azone from 3 to 7 μm with at least 90% of particles by mass, having a size less than 16 microns, preferably less than 12 microns.

In a specific embodiment, the silica is in the form of particles with such a size that they are effective for occlusion of the dentinal tubules. Thus, the average particle diameter of silica is preferably 0.5 to 10 microns, or 1 to 9 microns, or 2 to 7 microns with an average diameter of less than 5 microns is most preferred.

The amount of abrasion radioactive dentin (RDA) of the silica is in the range from 100 to 220. More often, the RDA value is in the range from 120 to 200, and usually the RDA value is more than 140. Typically, the silica with PAV above 15 have more than 120 RDA, and silica with PAV have more than 17 RDA over 140.

PCR (measured in composition to the teeth with 10% by mass) amorphous silicon dioxide is more than 85, preferably greater than 90, and more preferably more than 95. The ratio of PCR:RDA is preferably in the range from 0.5:1 to 0.9:1.

Preferably, the pH of amorphous silicon dioxide, as measured in 5% by weight of the slurry is in the range of 5 to 8, more preferably in the range of 6 to 7.5. The amount of water contained in the amorphous silica suitable for use in compositions for the teeth, as measured by loss on ignition at 1000ºC, usually up to 25% by mass, and before�occhialino to 15% by weight., generally, a loss on ignition at 1000ºC is more than 4% by mass.

In composition it is possible to use colorants such as pigments and dyes. Pigments include non-toxic, water insoluble inorganic pigments such as titanium dioxide and chromium oxide green, ultramarine blue and pink and iron oxides. The pigments have a particle size in the range of 5-1000 microns, preferably 250-500 microns, and contained in a concentration of from 0.5 to 3% by mass.

Used paint as a rule, are food coloring additives that are certified at the present time, according to the law on food products, drug substances, and cosmetic act for use in food and oral medicinal products, including dyes such as FD&CRed No. 3 (sodium salt of tetraiodofluorescein), FD&C Yellow No. 5 (sodium salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazol-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphthol-6-monosulphate), FD&C Green No. 3 (disodium salt of ethyl[4-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-[(3-sulfophenyl)methyl]Azania), FD&C Blue No. 1 (disodium salt acid Indigo) and their mixtures, in varying proportions. The preferred concentration of CRA�OK is in the range from 0.0005 to 1% of the total weight.

In a composition for caring for the oral cavity also you can enter any suitable flavoring or sweetener. Examples of suitable flavoring components include flavored oil, such as oil curly mint, peppermint, Wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon and orange, and methyl salicylate. Suitable sweeteners include sucrose, energy, lactose, maltose, sorbitol, xylitol, sodium cyclamate, peralatan and saccharin sodium. Accordingly flavouring substances contained in the composition for caring for the oral cavity in an amount of from 5% to 25% by mass, more preferably from 10% to 20% by weight and most preferably about 15% by weight. Sweeteners can be from 0.1 to 5% by mass, more preferably from 0.25 to 2% by weight and most preferably about 0.5% by weight of components to care for the oral cavity.

Oral compositions optionally contain one or more other active ingredients. Non-limiting examples include diluents, bicarbonate salts, a method of controlling pH, foam modulators, thickening tools, viscosity modifiers, coloring tools, sweeteners, flavors and dyes. Toothpastes, tooth gels and other compositions for the care of the oral cavity with these and formulate optional�tive other additives in accordance with known principles.

Composition for caring for the oral cavity is encapsulated in a gelatin capsule. The encapsulation of liquid or water compositions in gelatin capsule can be performed is known in the field methods described, for example, in U.S. patents Nos. 4422985, 4426337 and 5478570. The method generally includes forming a jet of a composition for caring for the oral cavity and the jet containing substance (e.g., gelatin), axis coincident with the jet composition for caring for the oral cavity, heating the coincident axis of the jets (with optional third axis coincident heating element or hot air) and the introduction of components into the coolant to obtain capsules formed from the composition for caring for the oral cavity, covered with gelatin. Although the composition is to care for the oral cavity preferably receive in the absence of alcohol, any alcohol contained in preparations to care for the oral cavity, preferably vaporizes upon heating of the respective components. Preferably the gelatin is from 6 to 15% of the total weight of the encapsulated composition to care for the oral cavity (i.e. capsules and compositions for caring for the oral cavity), more preferably from 8 to 12% and most preferably about 9%. Similarly, the composition for caring for the oral cavity ranges from 85 to 94% of the total weight encapsulite�Anna composition for caring for the oral cavity, more preferably from 88 to 92% and most preferably approximately 91%.

In one preferred aspect of the invention, the above encapsulated composition to care for the oral cavity is placed on the fixture to care for the oral cavity. For example, the encapsulated composition to care for the oral cavity can be placed on the head of the fixture to care for the oral cavity. This can be done with a premise encapsulated compositions for caring for the oral cavity in or between the cleaning elements of the fixture to care for the oral cavity. When applied to such a device for cleaning teeth, the amount of the composition to care for the oral cavity in the capsule, generally is in the range from 45 mg to 80 mg, preferably from 50 mg to 75 mg, and most preferably about 64 mg of product to care for the oral cavity.

Fixture to care for the oral cavity may contain a bursting dispenser containing a composition for caring for the oral cavity as a connecting link or various other combinations of components and substances as described. The dispenser containing the product to care for the oral cavity, such as described in the present description, the composition for caring for the oral cavity or other substance to care for the oral cavity, may be connected to a part of the bristles or cleaning element to adjust�of sablania to care for the oral cavity for distribution of the composition to care for the oral cavity on the teeth. In one of the structures of the elements to care for the oral cavity are made to slow radial flow of the composition to care for the oral cavity is released from the dispenser near the inner region of the carrier, and increase the radial flow of the substance to care for the oral cavity away from the inner region.

The composition described above in several preferred embodiments. Additional non-limiting description given in the examples that follow below.

Examples

Example 1

As indicated above, the inventors believe that the positive effects exerted by the invention partially relates to preventing or slowing the migration of hydrophilic active substances in a gelatin capsule during the cooling phase, upon receipt, when all layers of the capsule are in fact liquid. Thus, we studied the time of deposition of the particles for a series of compositions, as well as the viscosity of the compositions. At the time of deposition of the particles of this composition it is possible to predict the migration of the hydrophilic active substance from the composition in a gelatin capsule. The viscosity was measured to establish any relationship of viscosity and time of deposition of the particles.

These values were compared with the reference sample, WISP™ PLUS WHITENING, the viscosity of which is 317 SP, and the time of deposition of the particles is 20 minutes. Elm�spine reference sample of 317 SP is low enough such that it can be treated without difficulty. However, the time of deposition of the particles is not sufficient to eliminate the above problems caused by the rapid migration of hydrophilic active substances in a gelatin capsule. The time of deposition of the particles was determined by visual observation of the migration of suspended particles in powder form on the bottom of the vessel. For recording the time required for complete deposition of particles in powder form on the bottom of the vessel, used the stopwatch.

Therefore, the test formulations were evaluated regarding the composition of the comparison (control). The results are shown in table 1 below. The compositions over time, deposition of particles more than 20 minutes and viscosities equal to or less than approximately 317 SP, are ideal. These formulations essentially prevent the migration of hydrophilic active substances in a gelatin capsule at a stage of cooling/solidification upon receiving the capsules, but have a rather low viscosity, they are suitable for current conditions. Table 1 presents several test compositions with viscosities in the preferred range below 800 SP. Preferably the viscosity is less than or equal to 327 SP or 300-800 JV, or 150-330 SP.

Table 1
The viscosity and the sedimentation control and test formulations
CompositionCompositionComposition
IngredientControl123
Caprylic/capric triglyceride73,563,567,569,5
L-arginineX555
Gantrez S-97X222
PlastigelX842
Flavoring additive15151515
Coolant additive WS31,51,51,5
Sucralose+EtOH5555
Silica AC 435XXX
Total100100100100
Viscosity327 SP773550350
Time20 minutes>60 min20 minutes20 minutes

Example 2

Tested the effective in vitro method to determine the conductivity of the water. The flow of dentinal fluid is measured by a rotameter (Flodec) attached to the cell Pashli. The drive of the test sample before and after application of the product to ensure its own background values. The percent flow reduction calculated as the difference in the flow before and after treatment. The layer filled with the prototype of the active composition, in neat�emali on the surface of the disc, installed in the cell of Pasli, with subsequent manual cleaning for one minute modified with a small brush. The excess product was washed with PBS, and the flow was recorded after 10 and 15 minutes in simulated pulp pressure of 70 cm water. After 15 minutes, we measured a decrease in the flow in the sample on 92,42%.

Repeating the above experiments using a modified brush WISP showed that the efficiency is not reduced. Installed dentin disks were cleaned for one minute brush WISP and composition for caring for the oral cavity. These experiments on cleaning confirmed the use of brushes as a means of delivery of the product to the surface of teeth.

One of the variants of the implementation of the composition for caring for the oral cavity according to the invention were applied to the dentin disks installed on your cell Pashli, within 5 min. the Excess of the product was washed with PBS and disk checked the thread after 15 minutes when the simulated pulp pressure of 70 cm H2O. For the composition to care for the oral cavity according to the invention have been shown to decrease the fluid flow by approximately 90%. For a control sample consisting of encapsulated compositions for caring for the oral cavity that are currently available, WISP products, have been shown to decrease the flow is less than 25%.

The invention is described above in relation to the various�s preferred aspects, however, it should be understood that the invention is not limited to the described variants of implementation. Changes and modifications, which will offer the person skilled in the art, are also part of the invention, which is defined in the attached claims.

1. Composition for caring for the oral cavity that contains:
a) L-arginine,
(b) a film-forming polymer, a copolymer of methyl vinyl ether and maleic anhydride;
(c) a hydrophobic viscosity modifier containing a gelled mineral oil, which is an plastigel containing a polyethylene and mineral oil, in an amount sufficient to provide compositions for caring for the oral cavity over time, sedimentation of the particles is more than 20 minutes; and
(d) an oil carrier,
where the composition is to care for the oral cavity is encapsulated in a capsule containing gelatin, where the film-forming polymer is 1-5 wt.%, compositions for caring for the oral cavity, and where the hydrophobic viscosity modifier is more than 4 wt.%, compositions for caring for the oral cavity.

2. Composition for caring for the oral cavity according to claim 1, wherein L-arginine is contained in a quantity effective to reduce hypersensitivity of the teeth.

3. Composition for caring for the oral cavity according to claim 1 or 2, where L-arginine is 1-10 wt.%, compositions for caring for the oral cavity.

4. Songs�I to care for the oral cavity according to claim 1 or claim 2, where the carrier oil is 60 to 80 wt.%, compositions for caring for the oral cavity.

5. Composition for caring for the oral cavity according to claim 1 or 2,
where is the oil carrier comprises at least one of a vegetable oil and silicone oil.

6. Composition for caring for the oral cavity according to claim 1 or 2, where the carrier oil contains C6-C12-triglyceride.

7. Composition for caring for the oral cavity according to claim 1, where the composition is to care for the oral cavity further comprises 5-25 wt.%, flavour and 0.1-5 wt.%, sweetener.

8. Composition for caring for the oral cavity according to claim 1, where the composition is to care for the oral cavity further comprises at least one member selected from the group consisting of abrasives, antibacterial agents, foam-forming means, a bleaching agent, anti-plaque, anti-calculus, anti-inflammatories, anticaries funds, flavouring agent, sweetener and colorant.

9. Composition for caring for the oral cavity according to claim 1 or 2, where the carrier oil is a Caprylic/capric triglyceride, and a composition for caring for the oral cavity further comprises hydrated silica, sorbitol, energy, glycerin, colorant and flavoring.

10. Composition for caring for the oral cavity according to claim 1 or 2, ima�based viscosity from 300 to 800 SP.

11. Method of cleaning teeth comprising applying to the teeth a composition for caring for the oral cavity according to any one of claims. 1-10 so that the composition is to care for the oral cavity cleans teeth.

12. Fixture to care for the oral cavity that contains:
pen
mounted on the knob head, where the head contains the outer surface and a number of cleaning teeth element projecting outward on the outer surface; and
a gelatin capsule containing a composition for caring for the oral cavity according to any one of claims. 1-10, located on the head.

13. Fixture to care for the oral cavity according to claim 12, wherein the cleaning elements are made of an elastomeric substance.

14. Fixture to care for the oral cavity according to claim 12 or 13, wherein the capsule is located inside and surrounded by cleaning elements.



 

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FIELD: medicine.

SUBSTANCE: implementing the presented method involves mixing gel Hyaludent 1 ml on a slide with Betaleukin 0.0005 ml dissolved in water for injections 1 ml; the produced content is applied with a single application syringe on a desalivated treated area of the involved periodontal tissues and left until completely absorbed for 1-3 minutes; the involved area is exposed to laser light generated by the laser semiconductor dental therapeutic apparatus Optodan with a periodontal tip in the mode II, with the exposure length for 3-5 minutes; the therapeutic course is 8 days daily.

EFFECT: using the method enables achieving the fast regeneration length, ensuring the intact periodontal state in the most patients.

4 tbl, 3 ex

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SUBSTANCE: invention represents an agent for treating a pulp inflammation differing by the fact that it contains Bezornil ointment and Dycal ivory paste in ratio 1:1 blended until smooth.

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2 ex, 1 tbl

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SUBSTANCE: a phytopreparation containing bee wax 1.9 g and a herbal extract 0.1 g with the above herbal extract containing common oak bark, common St. John's wort herb and creeping thyme (Thymus) herb in equal proportions is used.The preparation is used as a chewing substrate (a chewing gum) for two weeks 3 times a day 15 minutes after meals.

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1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: vitamins A and E, novocaine blocades of parotid salivary glands, intake of potassium iodide solution, intake of galantamine, additionally administered is "Vezugen" in a dose of 2 tablets (capsules) 2 times per day for 30 days are administered.

EFFECT: invention makes it possible to stimulate the formation of own saliva in patients in case of drug sialoadenopathy, conditioned by chemotherapy of malignant tumours.

2 ex

FIELD: medicine.

SUBSTANCE: 20-25 minutes after surgical intervention, a mouth bath of an implantation area with the Tonsinal phytopreparation diluted in an amount of 2.5 g in 100 ml of boiled water of room temperature is executed. 20-25 minutes later the Plastin CM-1 phytopreparation is applied on the alveolar process mucosa within the implantation area from the vestibular side for 1.5-2 hours. That is preceded by the desalivation of the oral cavity and mouth rinsing carefully with the Tonsinal solution trying to avoid any dynamic movements. The above procedures are performed 3-4 times a day for at least 10 days.

EFFECT: more effective dental implantation by improving microcirculation, fast normalising of oral microbiocoenosis, wound surface healing by immediate union, reliable implant attachment to gums and providing the implant stability.

3 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to dentistry, and can be used for the treatment of conditions, related with the increased expression of MMP-13, selected from the group, consisting of loss of one or more teeth fixation, teeth loss, teeth mobility, formation of recesses, bone tissue loss and a combination of two and more of the said conditions. For this purpose the application of 4-acetamidophenyl 2-isopropyl-5-methylcyclohexylcarbonate in the production of a medication for the treatment of the said conditions is claimed. A composition for teeth care, containing an orally acceptable carrier and a therapeutically effective quantity of a MMP-13 inhibitor in the form of 4-acetamidophenyl 2-isopropyl-5-methylcyclohexylcarbonate is also claimed.

EFFECT: group of inventions provides the effective treatment of the said conditions die to effective MMP-13 suppression.

3 cl, 5 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: method involves professional oral hygiene is carried out consisting in ultrasonic removal of supra- and subgingival dental deposits and polishing of supragingival teeth. Bite splinting and recovery of dentition integrity may be required. After dissecting a mucoperiosteal flap according to the known technique, an incision area is sanitated by means of a photodynamic therapy (PDT). The PDT is conducted with the use of a diode laser at wave length 660±5 nm and emitting power 0.5-1.0 Wt. The photosensitiser "Photoditasin" in the form of 0.5% gel is introduced by means of a cannula into dental gaps, under the dissected segments of the flap and onto the mucosal tissue for 5 minutes. The photosensitiser is washed out, and the gingival pockets are repeatedly exposed to laser light for 2-3 min in the same environment. Sterile osteoplastic material is introduced into bone defects, and the flap is sutured together.

EFFECT: effective cleansing of the surgical area, eliminating the periodontal inflammation, stimulating tissue osteogenesis and regeneration, stabilising the processes of bone tissue absorption of alveolar interdental septa and preserving the tissues.

2 cl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, namely to an oral care composition and to a method for increasing the solubility of an active ingredient recovered from magnolia extract - tetrahydrohonokiol. The oral care composition contains an active ingredient recovered from the magnolia extract - tetrahydrohonokiol, propylene glycol and an orally acceptable carrier, in a certain amount.

EFFECT: content of the certain amount of propylene glycol in the oral care composition increases the solubility of tetrahydrohonokiol that leads to improving the effectiveness of its delivery and bioavailability.

3 cl, 8 tbl, 8 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for oral cavity care. Compositions include a multi-layered film and an orally acceptable carrier. The carrier contains the first flavouring agent, with the second flavour being contained in the present central layer of the multi-layered film, located between two external surface layers. The first and second flavouring agents can be similar or different. Each film layer can include a film-forming polymer, for instance, hydroxypropylmethylcellulose. The external layers can include a substance, modulating the release of the flavouring agent, for instance, polyvinylacetate or hydroxymethylcellulose. The carrier can be a means for teeth cleaning or a liquid for mouth rinsing.

EFFECT: obtaining the composition for oral cavity care.

22 cl, 3 dwg, 4 tbl, 11 ex

FIELD: medicine.

SUBSTANCE: vaseline-lanolin (2:1) based ointment 74.0 g is added with a 40% herbal alcoholate 25 ml of the following composition (in the mixture of a herbal raw material: alcohol base - 1:5), weight fractions: nodding catchfly herb - 3 weight fractions, pot marigold blossom - 1 weight fraction, spiraea herb - 1 weight fraction, with the ointment added with clove oil 1.0 ml. The prepared ointment is applied on inflamed periodontal and oral mucosal tissues for 20 minutes 2-3 times a day for 14 days; the patient is advised not to drink or eat for 1 hour.

EFFECT: method enables increasing clinical effectiveness by combining high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity and ease of use.

3 ex

FIELD: medicine.

SUBSTANCE: claimed invention relates to capsule for application with inhalator of dry powder, which contains composition in form of dry powder for pulmonary introduction, which contains mechanosynthesised microparticles, consisting of antibiotic and magnesium stearate.

EFFECT: invention relates to method of obtaining claimed capsule and its application in treatment of bacterial infection, associated with certain lungs diseases.

10 cl, 4 ex, 3 tbl, 1 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics, namely represents a method for producing an orally disintegrating tablet. The tablet is prepared by the method involving the stages of providing a liquid containing a drug substance, presenting a solid element having an at least one cavity formed thereof, cooling the solid element down to a temperature below a chilling temperature of the liquid, filling the cavity with the liquid, hardening the liquid in the cavity, rejecting heat from the liquid through a cavity wall by conductive heat transfer to form a solid granule containing a drug substance, with no active profiling along the whole surface of the granule, removing the granule from the cavity and drying the granule in vacuum.

EFFECT: developing the method for producing the orally disintegrating tablet.

15 cl, 4 ex, 6 tbl, 9 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely represents a method for the therapy of respiratory symptom. The method involves administering a liquid composition containing a gel former and/or a mucoactive polymer, a non-menthol cooling substance; and contacting the oral mucosa with the liquid composition. The invention also describes liquid compositions applicable in the method for the therapy of a respiratory disease.

EFFECT: implementing the method provides improving the cooling properties of the cooling agent N-(4-cyanomethylphenyl)-n-menthane carboxamide in the liquid composition by combining the non-menthol cooling substance with the gel former.

14 cl, 2 tbl, 5 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to quinolines substituted by phosphorus-containing group of formula and applicable in medicine, wherein Z represents V1 and V2 are independently specified in hydrogen or halogen; one of R and R` represent phosphorus-containing substitute Q; the other one is specified in hydrogen or methoxyl; wherein the phosphorus-containing substitute Q represents A represents O; L represents C1-6alkyl; J represents NH or C3-6heterocycloalkyl and J is optionally substituted by G3; X is absent or represents -C(=O)-; X is absent or represents C1-6alkyl; each of R1 and R2 are independently specified in C1-6alkyl or C1-6alkoxy; G3 represents C1-6alkyl, R3S(=O)m-, R5C(=O)- or R3R4NC(=O)-; R3, R4 and R5 are independently specified in 3 or C1-6alkyl; m is equal to 0-2.

EFFECT: there are presented new protein kinase inhibitors effective for treating the diseases associated with abnormal protein kinase activity.

20 cl, 42 ex, 8 tbl, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of pharmaceutics and deals with application of aqueous balanced solution of electrolytes as external washing solution, for washing and purification in case of surgery, for washing and purification of wounds and burns, for washing body cavities, for eye washing, for washing and purification of instruments and in servicing stomas or as carrier solution for compatible electrolytes, nutrients and medications. Aqueous balanced solution contains: 138-146 mmol/l of sodium, 4-5 mmol/l of potassium, 0.5-2.0 mmol/l calcium, 1.0-1.5 mmol/l of magnesium, 100-108 mmol/l of chloride, 0.5-1.5 mmol/l of phosphate, 18-26 mmol/l of gluconate, 20-28 mmol/l of acetate.

EFFECT: invention makes it possible to use aqueous balanced solution as effective means of external washing solution or as carrier solution for compatible electrolytes, nutrients and medications.

11 cl, 2 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: pro-apoptotic solid dispersion contains a compound, e.g. ABT-263 taken in a substantially non-crystalline form to inhibit Bcl-2 proteins and dispersed in a solid binding substance containing (a) a pharmaceutically acceptable water-soluble polymer carrier and (b) a pharmaceutically acceptable surfactant. A method for preparing this solid dispersion involving dissolving the compound, polymer carrier and surfactant in an acceptable dissolution medium and removing the dissolution medium to form the solid binding substance containing the polymer carrier and surfactant and possessing a compound dispersed therein in the substantially non-crystalline form.

EFFECT: solid dispersion is orally applicable in the individual in need thereof for treating a disease characterised by the overexpression of one or more anti-apoptotic Bcl-2 proteins, eg a malignant new growth.

22 cl, 6 ex, 2 tbl, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to medicine and deals with a method of obtaining an elongated implant, where the ratio of the diameter to the length on the implant axis constitutes between 1:20 and 1:40, for the controlled and delayed release of a GnRH analogue of triptorelin acetate. In addition, the group of inventions deals with the elongated implant, obtained in accordance with the said method.

EFFECT: group of inventions provides good control over triptorelin release from the implant.

11 cl, 26 ex, 6 dwg, 11 tbl

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and concerns a method for the delivery of octreotide or its pharmaceutically acceptable salt into an individual, involving implanting the implanted device comprising a polyurethane polymer into the individual; the implanted drug delivery device for the octreotide acetate release by diffusion through a polyurethane polymer.

EFFECT: group of inventions provides high biocompatibility and biostability when used as an implant for the patients for the octreotide delivery to tissues or organs.

4 cl, 3 dwg, 5 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, in particular to a pharmaceutical composition in the form of the extrudate, containing at least one pharmaceutically active substance in the form of needles, characterised by the fact that the ratio of the particle size of the needle-like active substance to the diameter of strands constitutes at least 1:25.

EFFECT: invention makes it possible to obtain the more homogeneous extrudate.

11 cl, 13 ex, 10 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a pharmaceutical composition containing N-[3-chlor-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5[[[2-(methylsulphonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine or its pharmaceutically acceptable salt as an active pharmaceutical ingredient in an amount of more than 60 wt % to less than 85 wt % as related to total weight of the composition. The active pharmaceutical ingredient is characterised by a wetting angle of less than 55°.

EFFECT: method for preparing the pharmaceutical composition involves the stage of grinding or milling the above pharmaceutical ingredient in the presence of one or more excipients.

7 cl, 7 dwg, 5 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: invention relates to the encapsulation of active ingredients and to processing textile materials. Claimed are: a method of processing textile materials, containing microcapsules of active ingredients, fibres and/or textile materials, obtained from the said method, and their cosmetic or pharmaceutical application and/or their application as a repellent.

EFFECT: claimed invention makes it possible to increase the active ingredient stability for an acceptable number of washings.

16 cl, 6 dwg

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