Method of obtaining l-arginine nanocapsules in sodium alginate

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining L-arginine nanocapsules in sodium alginate envelope. In the process of method realisation L-arginine is suspended in benzene. Obtained mixture is dispersed into suspension of sodium alginate in hexane in presence of preparation E472c with mixing at 1000 rev/sec. After that, chloroform is added, and obtained suspension of nanocapsules is filtered and dried at room temperature. Process is realised for 15 minutes.

EFFECT: method in accordance with invention provides simplification and acceleration of process of obtaining nanocapsules and increased output by weight.

3 ex

 

The invention relates to the field of nanotechnology, in particular to a method for producing nanocapsules of L-arginine in the sodium alginate.

Previously known methods for producing microcapsules.

In us Pat. 2173140, IPC A61K 009/50, A61K 009/127 Russian Federation, published 10.09.2001, a method of producing kremnijorganicheskih microcapsules using a rotary cavitation equipment with high shear forces and powerful hydroacoustic phenomena sonic and ultrasonic range for dispersion.

The disadvantage of this method is the use of special equipment - rotary-cavitational installation, which has the ultrasonic effect, which influences the formation of the microcapsules and thus may cause adverse reactions due to the fact that ultrasound has a destructive effect on polymers of protein nature, therefore, the proposed method is applicable when working with polymers of synthetic origin

In us Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 27.06.2009, Russian Federation, proposed a method of obtaining microcapsules of sodium chloride with the use of spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/m�called Microcapsules according to the invention have improved stability and provide adjustable and/or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, certain set of conditions (the air temperature at the inlet 10°C, the temperature at the outlet 28°C, the speed of rotation of the spray drum 10000 rpm/min).

The closest method is the method proposed in us Pat. 2134967, IPC A01N 53/00, A01N 25/28, published 27.08.1999, Russian Federation (1999). In water dispersed solution of a mixture of natural lipids and PYRETHROID insecticide in a weight ratio of 2-4:1 in an organic solvent, which leads to simplification of the method of microencapsulation.

The disadvantage is the dispersion in an aqueous medium, which makes the proposed method applicable for obtaining microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of producing nanocapsules, reducing loss upon receipt of the microcapsules (increase of the yield by weight).

The solution of a technical problem is achieved by a method of obtaining nanocapsules of L-arginine, characterized in that as the shell of the nanocapsules used sodium alginate, and as the kernel is L-arginine upon receiving�AI encapsulated particles by deposition of nerastvorim with the use of chloroform as a precipitant, the process of obtaining nanocapsules can be made without special equipment.

A distinctive feature of the proposed method is to obtain nanocapsules by deposition of nerastvorim using chloroform as the precipitant, and the use of sodium alginate as the shell particles and L-arginine - as the kernel.

The result of the proposed method are obtaining nanocapsules of L-arginine.

EXAMPLE 1 Obtaining nanocapsules of L-arginine in the sodium alginate, the ratio of sheath : core 1:5

5 g of L-arginine suspension in 10 ml of benzene and the resulting mixture is dispersed in the slurry of sodium alginate in hexane containing specified 1 g of the polymer in the presence of 0.01 g of the drug Is (an ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid as tribasic can be etherification other glycerides and as oxanilate - other fatty acids. Free acid groups can be neutralized with sodium) under stirring about 1000/sec. Next, pour 5 ml of chloroform. The resulting suspension was filtered and dried at room temperature.

Received 6 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 2 Obtaining nanocapsules of L-arginine in the sodium alginate, the ratio of sheath : core 3:1

1G of L-arginine suspension in 5 ml of benzene and the resulting mixture is dispersed in the slurry of sodium alginate in hexane, containing specified 3 g of the polymer in the presence of 0.01 g of the drug Is under stirring about 1000/sec. Next, pour 3 ml of chloroform. The resulting suspension was filtered and dried at room temperature.

Received 4 g of powder of nanocapsules. The yield was 100%.

EXAMPLE 3 Obtaining nanocapsules of L-arginine in the sodium alginate, the ratio of sheath : core 1:1

1 g of L-arginine suspension in 10 ml of benzene and the resulting mixture is dispersed in the slurry of sodium alginate in hexane containing specified 1 g of the polymer in the presence of 0.01 g of the drug Is under stirring about 1000/sec. Next, pour 5 ml of chloroform. The resulting suspension was filtered and dried at room temperature.

Received 6 g of powder of nanocapsules. The yield was 100%.

Thus, the obtained nanocapsules of L-arginine with a high yield without special equipment within 15 min.

A method of producing nanocapsules of L-arginine in the sodium alginate, characterized in that as the shell of the nanocapsules used sodium alginate, and as the kernel is L-arginine, L-arginine suspended in benzene, the resulting mixture is dispersed in the slurry of sodium alginate in hexane in the presence of the drug Is under stirring about 1000/sec, then add the chloroform, the resulting suspension of nanocapsules was filtered off and dried at room temperature, about�the ESS is carried out for 15 min.



 

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