Method for local treatment of oral lichenplanus with using chewing phytosubstrate
SUBSTANCE: a phytopreparation containing bee wax 1.9 g and a herbal extract 0.1 g with the above herbal extract containing common oak bark, common St. John's wort herb and creeping thyme (Thymus) herb in equal proportions is used.The preparation is used as a chewing substrate (a chewing gum) for two weeks 3 times a day 15 minutes after meals.
EFFECT: using the invention improves clinical manifestations of the disease; oral inflammations are supposed to relieve or reduce; the length of erosion and ulcer epithelisation is reduced; the oral fluid structural properties are normalised by increasing phosphorus and magnesium, reducing protein, calcium and TBA.
1 tbl, 1 ex
The invention relates to medicine, specifically to clinical dentistry, can be used to treat diseases of the oral mucosa (COP), namely, lichen planus of the oral mucosa.
Lichen planus (LP) is a chronic disease with eruptions of papules, affecting epithelial tissue; clinically manifested on the skin and mucous membranes. The defeat of the oral mucosa in lichen planus may be associated with skin lesions, but often is isolated. The disease is one of the most common lesions of the COP, a favorite location is the buccal mucosa, lateral and dorsal surface of tongue, rarely - transitional mucosa folds, lips, and floor of the mouth. More common in women 30 to 60 years. The clinical picture and course of lichen planus on the oral mucosa are significantly different from its manifestations in the skin, due to the peculiarities of the structure of the oral mucosa, as well as the specificity of the biological and physico-chemical processes in the oral cavity related to the presence of foci of focal infection, fillings and prostheses made of various metals, the composition and properties of saliva, the primary processes of digestion of food [Dovzhansky S. I., Slesarenko N. And. Clinical features, immunopathogenesis and therapy of cu�eautiful lichen planus. Ross. honey. log. 1998. - No. 6. Pp. 348-352].
According to the classification proposed by Miscellanea A. L. and Borovsky E. V. (1984) highlighted the following clinical forms of lichen planus of the oral mucosa: a typical exudative-hyperemic, erosive, bullous, form may be accompanied, atypical [Mashkillejson A. L. planus. In the book: Diseases of the mucous membranes of the mouth and lips. - M. - 1984. Pp. 190-204].
Today the problem of treatment of the LCP represents an important, and until the end of the unsolved problems of clinical dentistry.
The most significant of the primary stages of complex therapy of the CPL COP, in addition to etiotropic and pathogenetic therapy, is a local conservative treatment.
Herbal medicine is currently becoming more widespread because it has minimal risk of side effects and allergic reactions. This is especially important in patients with LCP COP, because the disease is always combined with somatic pathology. The question remains about the development of herbal remedies that are safe affect the pathogenesis of disease in the oral cavity, and easy to use for patients with LCP COP. Arsenal of herbal medicines used in local therapy of the LCP in recent years has expanded is the solution�, ointment, a variety of composite biomaterials containing shikonin, emoxipin, parmidin [L. M. Lukins, Irina tiunova N. In. Optimization of treatment of lichen planus of the mucous membranes of the oral cavity. Maestro dentistry. 2009. - No. 4. - P. 79-81; Ependymoma E. L., Rabinovich O. F. Methods of diagnosis and local treatment of diseases of the oral mucosa (lichen planus, recurrent aphthous stomatitis, decubital ulcers). Dentistry. - 2005. - No. 3. - P. 58-63; V. P. Papageorgiou, A. N. Assimopoulou, A. Ballis, S. Alkannins and shikonins: a new class of wound healing agents. Current Medicinal Chemistry. 2008. - Vol.15. - P. 3248-3267].
However, these drugs have a number of disadvantages: slight adhesion to the affected area, and high solubility in oral fluids, are difficult to use (in liquid form-in the form of applications on gauze napkins).
Traditionally used medicines and methods of their administration have significant drawbacks. When conducting irrigation, installations drugs are rapidly leached oral liquid, reducing the required therapeutic concentration.
The main problem with topical application of medicinal compositions is the problem of creating effective concentration in inflammation and maintaining this concentration for the necessary for the treatment period.
The closest analogue of the invention is a method of local treatment�I CPL COP, including rinsing 15% aqueous solution of stomatopoda (10 ml extract stomatopoda dissolved in ¼ Cup water) While the drug is astringent, soothing, anti-inflammatory, antiseptic, antibacterial action on the mucous membrane of the mouth. Rinse the mouth 4 times a day for 10-20 days [I. V. Anisimova, M. O. Nagaeva Clinical and laboratory evaluation of local application of herbal medicines "Stomatitis" and "Stomatofit And" in complex treatment of diseases of the oral mucosa. 2010. - No. 1. - P. 55-57].
However, this method of local treatment has a number of drawbacks: slight adhesion to the affected area, and high solubility in oral fluids, inconvenience in use. Creates insufficient concentration of the drug in the lesion and, consequently, a limited therapeutic effect.
The object of the invention is to provide a method of treatment using chewing fitosanitaria, allowing to increase the effectiveness of treatment of the LCP COP by the prolonged action of medicinal substances of plant origin in the lesion.
The technical result when using the invention - improving clinical indicators: a decrease and disappearance of inflammation on the mucous membrane of the mouth, flattening of the papules, shortening apical�tion of erosions and ulcers, the normalization of the structural properties of the oral fluid of patients with LCP COP.
The proposed method of local treatment in patients with LCP COP is as follows: apply an herbal medicinal product containing 1.9 g of beeswax and 0.1 g of the extract of the collection of medicinal plants containing the bark of oak-trees, grass Hypericum perforatum and grass creeping thyme (thyme), taken in equal amounts. The drug is used as chewing substrate (chewing gum) within two weeks 3 times a day for 15 minutes after eating. To improve therapeutic effect is recommended within one hour of not eating.
The plants used are approved for use in the officinal medicine and are widely spread on the territory of the Russian Federation and, in particular, in Bashkiria. Extracts retain all the positive aspects of infusions and decoctions, and virtually no drawbacks and conserve natural resources. Use of extracts significantly expands the range of complex herbal remedies, because on their basis it is possible to prepare various dosage of medicines for internal and external use. In addition, technological approaches allow to obtain the extracts, containing in concentrated form the main biologically active substances, due to�which is determined by high pharmacological activity and their significant pharmacological effect in the relevant pathological conditions.
Beeswax is a solid granular substance secreted wax glands of young bees by eating their honey or pollen. It has more than 300 different compounds (esters, free fatty acids, hydrocarbons, water, flavorings, almost all macro - and micronutrients). In wax 13-15 free fatty acids, 12-17% are saturated hydrocarbon. Also contains carotenoids - 12,8 (4096 ME) in 100 g of wax, which is 400 times more than in carrots. Beeswax is recommended as a medicine anti-inflammatory, wound healing, astringent character that is used to cleanse the mouth and strengthening the mucous membranes.
therapeutic effect of chewing substrate is manifested by the fact that the chewing of the basis substrate contains beeswax, and as a dietary Supplement, extract, collect medicinal plants, consisting of the bark of oak-trees, grass Hypericum perforatum and creeping thyme (thyme), as well as the synergistic effect of its components. In addition, we suggest chewing the substrate does not contain synthetic polymers, which are undesirable for patients with LCP COP.
Used photosupload prepared as follows. Prepare the collection of a mass of 300 g of oak bark (Quercus robur), herb St. John's wort and herbs� creeping thyme (thyme). The raw material is taken in equal amounts (100 g each). Pour collect 3 liters of room temperature water and leave for days. In a day filled collection is extracted in a water bath to reflux during one hour. Then extracted, filtered and placed in a refrigerator. Further, this same raw pour 3 liters of 40% ethanol and left overnight. In a day filled collection is extracted in a water bath to reflux during one hour. Then extract, again filtered off and combined with water obtained earlier. Further, the combined extract was evaporated on water bath to obtain a thick extract, which is then injected into the melted wax and mix thoroughly. The resulting mass is poured into molds. In one chewable weighing 2 g contains 0.1 g of the extract (single dose).
The advantages of the proposed method of treatment are as follows:
1. Due to the use in the form of chewing gum is due to the prolongation of the action of medicinal substances.
2. Accelerate the time of treatment.
3. There are no systemic side effects.
5. The method is convenient and easy to use.
6. There are no negative reactions in patients.
The proposed method of local treatment used to treat 30 patients with lichen planus of the oral mucosa with various�bubbled forms, the control group consisted of 30 people of the same age without the LCP COP. The treatment efficiency was evaluated in the dynamics of subjective symptoms and clinical picture.
In this paper we study the dental status, determination of some biochemical parameters of oral fluid. Dental examination included medical history and complaints, external inspection, assessment of the state of dentition, oral mucosa, periodontal tissues. In oral fluid was determined the content of total protein, total calcium, phosphorus, magnesium (reagent kits "Vector-best") and TBA-active products (reagent kits "AGAT-MED") before and after the chewing of the substrate, consisting of 1.9 g of beeswax and 0.1 g of the extract of the collection of medicinal plants containing the bark of oak-trees, grass Hypericum perforatum and grass creeping thyme (thyme) in equal amounts. It was used as a chewing gum that caused the prolongation of the action of medicinal substances. Took 1 fitosanitario 3 times a day between meals for 2 weeks. Then again collected oral fluid.
In samples of mixed saliva was determined by the amount of calcium, magnesium, phosphorus, protein and TBA-active products. When you change the levels of calcium with 2,31±0,11 mmol/l to 1.64±0,12 mmol/l, magnesium from 0.48±0,07 mmol/l to 0.94±0,03 mmol/l, �of Ostra with 4,23±0,08 mmol/l to 5.05±0,15 mmol/l, protein with 2.38±0.12 g/l to 1.76±0.11 g/l, with a decrease of TBA-active products 3,38±0.02 to 2,37±0.01 the effectiveness of the treatment was evaluated as positive.
Protein in oral fluid in persons of the main group before the application of fitosanitaria were 2.38±0.12 µmol/l, after - 1,76±0,11 mmol/l (difference authentically p < 0,05); a control group of patients is 2.01±0.09 μmol/L. TBA-active products in the oral fluid in persons of the main group before the application of fitosanitaria amounted to 3.38±0,02, after - 2,37±0,01 (difference authentically p < 0,05); in the control group of patients the rate was equal to 2,15±0,01.
Calcium in the oral fluid in persons of the main group before the application of fitosanitaria amounted 2,31±0,11 mmol/l, after - 1,64±0,12 mmol/l (difference authentically p < 0,05); a control group of patients - 1,93±0,04 mmol/l Magnesium in oral fluid in persons of the main group before the application of fitosanitaria was 0.48±0,07 mmol/l, after - 0,94±0,03 mmol/l (difference authentically p < 0,05); a control group of patients - 0,72±0,02 mmol/l Phosphorus in the oral fluid in persons of the main group before the application of fitosanitaria amounted to 4.23±0,08 mmol/l, after - 5,05±0,15 mmol/l (difference authentically p < 0,05); the control group patients - a 4.53±0,11 mmol/l (table). Thus, the evaluation of the effectiveness of chewing substrate containing 1.9 g of beeswax and 0.1 g of the extract collection of medicinal plants, has a population�of boiling oak bark (Quercus robur), the herb St. John's wort and grass creeping thyme (thyme) in equal amounts, in the treatment of the LCP COP showed positive results.
Clinically this is manifested by the decrease and disappearance of inflammation in the mucosa of the mouth, flattening of the papules, reduce the time of epithelialization of erosions and ulcers, the normalization of the structural properties of the oral fluid of patients with LCP COP. Biochemical study of oral fluid showed an increase in phosphorus and magnesium, reduction of protein, calcium and TBA-active products.
The invention is illustrated by the following clinical example.
Patient I. turned to the dental clinic Manakin with complaints of tightness of the mucous membranes of the mouth, whitish education on the mucous membrane of the cheeks.
Objectively: the mucous membrane of the cheeks are gray-white papules coalesce in a whimsical pattern lace, buccal mucosa pale pink, painless on palpation.
Diagnosis: lichen planus is a typical form.
As local treatment was prescribed photosupload, consisting of 1.9 g of beeswax and 0.1 g of the extract of the collection of medicinal plants containing the bark of oak-trees, grass Hypericum perforatum and grass creeping thyme (thyme) in equal amounts 3 times a day for 14 days.
On day 9 was observed�again papules without signs of inflammation, flattened. After treatment, the patient no complaints, the mucous membrane of the mouth pale pink color with a single flattened papules.
Method of local treatment of lichen planus of the oral mucosa, which includes the use of herbal medicinal product containing extracts of collection of medicinal plants containing oak bark (Quercus robur) and the herb thyme, characterized in that the quality of the herbal medicinal product used chewing substrate containing 1.9 g of beeswax and 0.1 g of the extract collection of medicinal plants, additionally containing the herb St. John's wort and thyme grass creeping thyme (thyme) with an equal number of components of the collection, within two weeks 3 times a day for 15 minutes after eating.
SUBSTANCE: vitamins A and E, novocaine blocades of parotid salivary glands, intake of potassium iodide solution, intake of galantamine, additionally administered is "Vezugen" in a dose of 2 tablets (capsules) 2 times per day for 30 days are administered.
EFFECT: invention makes it possible to stimulate the formation of own saliva in patients in case of drug sialoadenopathy, conditioned by chemotherapy of malignant tumours.
SUBSTANCE: 20-25 minutes after surgical intervention, a mouth bath of an implantation area with the Tonsinal phytopreparation diluted in an amount of 2.5 g in 100 ml of boiled water of room temperature is executed. 20-25 minutes later the Plastin CM-1 phytopreparation is applied on the alveolar process mucosa within the implantation area from the vestibular side for 1.5-2 hours. That is preceded by the desalivation of the oral cavity and mouth rinsing carefully with the Tonsinal solution trying to avoid any dynamic movements. The above procedures are performed 3-4 times a day for at least 10 days.
EFFECT: more effective dental implantation by improving microcirculation, fast normalising of oral microbiocoenosis, wound surface healing by immediate union, reliable implant attachment to gums and providing the implant stability.
SUBSTANCE: group of inventions relates to medicine, namely to dentistry, and can be used for the treatment of conditions, related with the increased expression of MMP-13, selected from the group, consisting of loss of one or more teeth fixation, teeth loss, teeth mobility, formation of recesses, bone tissue loss and a combination of two and more of the said conditions. For this purpose the application of 4-acetamidophenyl 2-isopropyl-5-methylcyclohexylcarbonate in the production of a medication for the treatment of the said conditions is claimed. A composition for teeth care, containing an orally acceptable carrier and a therapeutically effective quantity of a MMP-13 inhibitor in the form of 4-acetamidophenyl 2-isopropyl-5-methylcyclohexylcarbonate is also claimed.
EFFECT: group of inventions provides the effective treatment of the said conditions die to effective MMP-13 suppression.
3 cl, 5 tbl, 5 ex
SUBSTANCE: method involves professional oral hygiene is carried out consisting in ultrasonic removal of supra- and subgingival dental deposits and polishing of supragingival teeth. Bite splinting and recovery of dentition integrity may be required. After dissecting a mucoperiosteal flap according to the known technique, an incision area is sanitated by means of a photodynamic therapy (PDT). The PDT is conducted with the use of a diode laser at wave length 660±5 nm and emitting power 0.5-1.0 Wt. The photosensitiser "Photoditasin" in the form of 0.5% gel is introduced by means of a cannula into dental gaps, under the dissected segments of the flap and onto the mucosal tissue for 5 minutes. The photosensitiser is washed out, and the gingival pockets are repeatedly exposed to laser light for 2-3 min in the same environment. Sterile osteoplastic material is introduced into bone defects, and the flap is sutured together.
EFFECT: effective cleansing of the surgical area, eliminating the periodontal inflammation, stimulating tissue osteogenesis and regeneration, stabilising the processes of bone tissue absorption of alveolar interdental septa and preserving the tissues.
2 cl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry, namely to an oral care composition and to a method for increasing the solubility of an active ingredient recovered from magnolia extract - tetrahydrohonokiol. The oral care composition contains an active ingredient recovered from the magnolia extract - tetrahydrohonokiol, propylene glycol and an orally acceptable carrier, in a certain amount.
EFFECT: content of the certain amount of propylene glycol in the oral care composition increases the solubility of tetrahydrohonokiol that leads to improving the effectiveness of its delivery and bioavailability.
3 cl, 8 tbl, 8 ex
SUBSTANCE: invention relates to medicine and is intended for oral cavity care. Compositions include a multi-layered film and an orally acceptable carrier. The carrier contains the first flavouring agent, with the second flavour being contained in the present central layer of the multi-layered film, located between two external surface layers. The first and second flavouring agents can be similar or different. Each film layer can include a film-forming polymer, for instance, hydroxypropylmethylcellulose. The external layers can include a substance, modulating the release of the flavouring agent, for instance, polyvinylacetate or hydroxymethylcellulose. The carrier can be a means for teeth cleaning or a liquid for mouth rinsing.
EFFECT: obtaining the composition for oral cavity care.
22 cl, 3 dwg, 4 tbl, 11 ex
SUBSTANCE: vaseline-lanolin (2:1) based ointment 74.0 g is added with a 40% herbal alcoholate 25 ml of the following composition (in the mixture of a herbal raw material: alcohol base - 1:5), weight fractions: nodding catchfly herb - 3 weight fractions, pot marigold blossom - 1 weight fraction, spiraea herb - 1 weight fraction, with the ointment added with clove oil 1.0 ml. The prepared ointment is applied on inflamed periodontal and oral mucosal tissues for 20 minutes 2-3 times a day for 14 days; the patient is advised not to drink or eat for 1 hour.
EFFECT: method enables increasing clinical effectiveness by combining high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity and ease of use.
SUBSTANCE: on completion of the antibacterial course, sodium hyaluronate in the form of a gel is single administered by means of a syringe with a needle of 2 cm long or more under an oral mucosa along a transitory fold into the points within projections of apexes of dental roots 1.4, 2.4, 3.6, 4.6 and into a point on the mid-line of projections of apexes of anterior roots of upper and lower jaw respectively. The needle is brought under the mucosa on the lower jaw by transecting the projections of an alveolar counterfort line. On the upper jaw - by transecting the projections of the upper counterfort line. While removing the needle from the mucosa, the syringe content is squeezed out. Sodium hyaluronate is administered into both jaws in an amount of 3.0 to 4.4 ml.
EFFECT: method enables increasing the jaw bone density within counterforts, as well as soft and bone tissues of periodontium.
4 tbl, 16 dwg, 3 ex
SUBSTANCE: invention refers to dentistry and concerns treating chronic generalised periodontitis. Implementing the above method is ensured by a complex preparation in the form of an ointment of the following composition: Vaselin - lanolin base (1:1) - 88.5 g, 70% ipecac infusion - 5.0 g, 70% scholar tree - 5.0 g, Ecdysterone - 0.02 g; eucalyptus oil - 1.0 g. The oil is applied as a therapeutic periodontal applicate on a gingival surface following application anaesthesia with 10% lidocaine, chairside oral hygiene, drug-induced treatment of the gingival margin with 1% Iodinolum and separation of salivary glands in the oral cavity, once a day for 2 hours for 4 weeks; the patients are recommended not to eat or drink for two hours. The preparation composition particularly provides capillary-reinforcing, anti-inflammatory, reparative and anaesthetic action.
EFFECT: method of treating is easy to use, physiologically-friendly, and provides the complete recovery.
SUBSTANCE: invention relates to a compound of formula (I) : or a salt thereof, wherein R1 and R5 are independently selected from H, OH and alkoxy; R2-R4 and R6-R8 are independently selected from H, OH, F, Cl, Br and I; R9 and R10 are C2-C8 alkenyl; under the condition that at least one of R1, R5 and R7 is OH or alkoxy; at least one of R2-R4, R6 and R8 is F, Cl, Br or I; and R2 and R6 are Cl. The invention also relates to an antibacterial composition and treatment methods.
EFFECT: improved properties.
18 cl, 7 ex, 10 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to a composition for treating throat pain in the form of dispersible tablets. The claimed composition contains an endothermic cooling substance, representing xylitol, in an amount of 1-10 wt/wt % and an active substance, which contains menthol and 2,4-dichlorobenzyl alcohol and amylmetacresole.
EFFECT: invention ensures relief of symptoms, associated with throat pain, and ensures a cooling effect.
5 cl, 1 tbl
SUBSTANCE: chewable substrate contains a chewable base and an herbal extract as an active substance, wherein as the extract, the substrate contains a condensed red-haw hawthorn polyextract 10.0 g dried to residual humidity 25%, while the base is presented by sorbitol 40.0 g, apricot gum 15.0 g, gelatin 10.0 g, citric acid 1.0 g and purified water 100.0 g. The chewable substrate is applied 3 times a day for 15 minutes for 2 weeks, taken in a quantity of 1 substrate chewable until dissolved completely at an average weight of one substrate of 4.0 g.
EFFECT: using the method enables reducing oral xerosis, prolabium, coated tongue, rate of burning mouth syndrome, burning sensation and bad taste, normalising physical-chemical characteristics of the oral fluid.
4 tbl, 1 ex
SUBSTANCE: invention relates to medicine. Described is a tasty edible soft chewing carrier for a medication for delivery of an acceptable active ingredient, such as the medication for an animal or a human. Edible soft chewing products contain inactive ingredients of food grade only or of a better quality and preferably do not contain ingredients of animal origin.
EFFECT: methods of manufacturing edible soft chewing products do not require application of heat or addition of water in the process of mixing active and inactive ingredients, provide stable concentrations of the active ingredient and give chewing products with constant weight and texture.
12 cl, 3 ex
SUBSTANCE: group of inventions refers to medicine, namely to dentistry, and may be used as an oral composition for controlling an oral sweetener release. The above composition contains a polymer attached to the sweetener by a breakable link comprising a covalent bond, an ester bond or an amide bond. The breakable link is breakable in the oral cavity to release the sweetener. Said polymer is a polymer adhered to the mucosa and specified in methyl vinyl ether/maleic anhydride copolymer with polymer found in the amount of 0.001% to 10%. The sweetener is specified in dextrose, saccharose, maltose, dextrin, dried invert suger, mannose, xylose, ribose, fructose, lexulose, galactose, corn syrup, partially hydrolysed starch, sorbitol, mannitol, isomalt, aspartame, neotame, saccharine and its salts, sucralose, the sweeteners on the basis of dipeptides, cyclamates, dihydrochalcone with the sweetener content making 0.005% to 5%. What is also presented is a portable dispenser, a method for preparing the oral composition, a method for controlling the sweetener in the oral cavity, and using the polymer.
EFFECT: group of inventions enables the prolonged and/or more uniform sweetener release as compared to the oral compositions containing the sweeteners not attached to the polymer.
15 cl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine. There are described specific types of nicotin-containing chewing gums providing high transbuccal absorption rate, high plasma concentrations for the first 10 minutes after use in an individual chosen to give up smoking.
EFFECT: higher efficiency.
10 cl, 3 tbl, 35 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: coated pharmaceutical product for nicotine delivery into an individual in any form contains at least one core, nicotine in any form and/or a nicotine-imitating agent, at least one coating layer, and optionally one or more additions wherein at least said coating layer contains a buffer agent containing at least one amino acid. Amino acid is specified in a group consisting of asparagine, glutamic acid, glutamine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, valine, cysteic acid, N-glycylglycine and ornithine. There are also provided a method for nicotine delivery in any form, a method for reduction of craving to smoke or use tobacco, as well as a method for preparing said coated product and applying it for ensuring fast oral nicotine absorption.
EFFECT: invention provides fast oral nicotine absorption; pharmaceutical product under the invention is characterised by the satisfactory organoleptic properties.
49 cl, 3 tbl, 6 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry, and concerns coated oral dosage forms for nicotine delivery in any form to a subject by fast oral delivery containing at least one core, nicotine in any form and/or a nicotine imitating agent, at least one coating layer, and optionally at least one or more other additive wherein said at least one coating layer is buffered with at least trometamol used as a buffering agent.
EFFECT: there are provided method for nicotine delivery in any form, method for reduction of craving to smoke or using tobacco, as well as method for preparing said product and applying it for ensuring fast oral nicotine absorption.
46 cl, 6 ex, 2 tbl, 3 dwg
SUBSTANCE: invention refers to hygiene and concerns chewing oral care masses based on foamed synthetic polymers of aqueous dispersed polyurethane. The invention also concerns a method for producing such chewing masses.
EFFECT: invention provides new chewing masses suitable for oral care and not subject to plastic deformation.
8 cl, 1 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to methods of reducing dental caries in mammals, which includes introduction into oral cavity chewing gum product, which contains gummy base in amount from 5 to 95% of product weight, sweetener in amount from 0.001 to 90% and casein calcium phosphopeptide-phosphate (CPP-ACP) in amount, at least, 3% of product weight, product chewing three times per day during 10 minutes per session.
EFFECT: invention ensures retardation of development and enhancement of caries affection regression in mammals, in particular in people.
20 cl, 6 ex, 5 tbl
SUBSTANCE: present invention relates to a chewing gum product based on a chewing gum composition containing acid and free from sodium bicarbonate, containing a gum base, sweeteners, caseic phosphopeptide-calcium phosphate (CPP-ACP) and food acids.
EFFECT: compositions can be used for remineralisation of the surface of teeth, as well as for endowing said surface with acid resistance, which enables to improve the state of teeth in mammals.
8 cl, 6 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to pharmaceutical industry, namely to composition for treating skin ageing. Composition for treating signs of skin ageing, increase of cytikin IL-1α secretion, contains: NF-kB inhibitor, selected from the group, consisting of substituted resorcinols, (E)-3-(4-methylphenylsulphonyl)-2-propenenitrile, tetrahydrokurkuminoids, extracts of Paulownia tomentosa wood, as well as their combinations, and anti-inflammatory compound, which is not NF-kB inhibitor. Composition for treating signs of skin ageing, increase of cytokine IL-1α, containing NF-kB inhibitor, selected from the group, consisting of substituted resorcinols, and anti-inflammatory compound (versions).
EFFECT: compositions are effective for treating signs of skin ageing.
4 cl, 9 tbl, 9 ex