Method for local treatment of oral lichenplanus with using chewing phytosubstrate

FIELD: medicine.

SUBSTANCE: a phytopreparation containing bee wax 1.9 g and a herbal extract 0.1 g with the above herbal extract containing common oak bark, common St. John's wort herb and creeping thyme (Thymus) herb in equal proportions is used.The preparation is used as a chewing substrate (a chewing gum) for two weeks 3 times a day 15 minutes after meals.

EFFECT: using the invention improves clinical manifestations of the disease; oral inflammations are supposed to relieve or reduce; the length of erosion and ulcer epithelisation is reduced; the oral fluid structural properties are normalised by increasing phosphorus and magnesium, reducing protein, calcium and TBA.

1 tbl, 1 ex

 

The invention relates to medicine, specifically to clinical dentistry, can be used to treat diseases of the oral mucosa (COP), namely, lichen planus of the oral mucosa.

Lichen planus (LP) is a chronic disease with eruptions of papules, affecting epithelial tissue; clinically manifested on the skin and mucous membranes. The defeat of the oral mucosa in lichen planus may be associated with skin lesions, but often is isolated. The disease is one of the most common lesions of the COP, a favorite location is the buccal mucosa, lateral and dorsal surface of tongue, rarely - transitional mucosa folds, lips, and floor of the mouth. More common in women 30 to 60 years. The clinical picture and course of lichen planus on the oral mucosa are significantly different from its manifestations in the skin, due to the peculiarities of the structure of the oral mucosa, as well as the specificity of the biological and physico-chemical processes in the oral cavity related to the presence of foci of focal infection, fillings and prostheses made of various metals, the composition and properties of saliva, the primary processes of digestion of food [Dovzhansky S. I., Slesarenko N. And. Clinical features, immunopathogenesis and therapy of cu�eautiful lichen planus. Ross. honey. log. 1998. - No. 6. Pp. 348-352].

According to the classification proposed by Miscellanea A. L. and Borovsky E. V. (1984) highlighted the following clinical forms of lichen planus of the oral mucosa: a typical exudative-hyperemic, erosive, bullous, form may be accompanied, atypical [Mashkillejson A. L. planus. In the book: Diseases of the mucous membranes of the mouth and lips. - M. - 1984. Pp. 190-204].

Today the problem of treatment of the LCP represents an important, and until the end of the unsolved problems of clinical dentistry.

The most significant of the primary stages of complex therapy of the CPL COP, in addition to etiotropic and pathogenetic therapy, is a local conservative treatment.

Herbal medicine is currently becoming more widespread because it has minimal risk of side effects and allergic reactions. This is especially important in patients with LCP COP, because the disease is always combined with somatic pathology. The question remains about the development of herbal remedies that are safe affect the pathogenesis of disease in the oral cavity, and easy to use for patients with LCP COP. Arsenal of herbal medicines used in local therapy of the LCP in recent years has expanded is the solution�, ointment, a variety of composite biomaterials containing shikonin, emoxipin, parmidin [L. M. Lukins, Irina tiunova N. In. Optimization of treatment of lichen planus of the mucous membranes of the oral cavity. Maestro dentistry. 2009. - No. 4. - P. 79-81; Ependymoma E. L., Rabinovich O. F. Methods of diagnosis and local treatment of diseases of the oral mucosa (lichen planus, recurrent aphthous stomatitis, decubital ulcers). Dentistry. - 2005. - No. 3. - P. 58-63; V. P. Papageorgiou, A. N. Assimopoulou, A. Ballis, S. Alkannins and shikonins: a new class of wound healing agents. Current Medicinal Chemistry. 2008. - Vol.15. - P. 3248-3267].

However, these drugs have a number of disadvantages: slight adhesion to the affected area, and high solubility in oral fluids, are difficult to use (in liquid form-in the form of applications on gauze napkins).

Traditionally used medicines and methods of their administration have significant drawbacks. When conducting irrigation, installations drugs are rapidly leached oral liquid, reducing the required therapeutic concentration.

The main problem with topical application of medicinal compositions is the problem of creating effective concentration in inflammation and maintaining this concentration for the necessary for the treatment period.

The closest analogue of the invention is a method of local treatment�I CPL COP, including rinsing 15% aqueous solution of stomatopoda (10 ml extract stomatopoda dissolved in ¼ Cup water) While the drug is astringent, soothing, anti-inflammatory, antiseptic, antibacterial action on the mucous membrane of the mouth. Rinse the mouth 4 times a day for 10-20 days [I. V. Anisimova, M. O. Nagaeva Clinical and laboratory evaluation of local application of herbal medicines "Stomatitis" and "Stomatofit And" in complex treatment of diseases of the oral mucosa. 2010. - No. 1. - P. 55-57].

However, this method of local treatment has a number of drawbacks: slight adhesion to the affected area, and high solubility in oral fluids, inconvenience in use. Creates insufficient concentration of the drug in the lesion and, consequently, a limited therapeutic effect.

The object of the invention is to provide a method of treatment using chewing fitosanitaria, allowing to increase the effectiveness of treatment of the LCP COP by the prolonged action of medicinal substances of plant origin in the lesion.

The technical result when using the invention - improving clinical indicators: a decrease and disappearance of inflammation on the mucous membrane of the mouth, flattening of the papules, shortening apical�tion of erosions and ulcers, the normalization of the structural properties of the oral fluid of patients with LCP COP.

The proposed method of local treatment in patients with LCP COP is as follows: apply an herbal medicinal product containing 1.9 g of beeswax and 0.1 g of the extract of the collection of medicinal plants containing the bark of oak-trees, grass Hypericum perforatum and grass creeping thyme (thyme), taken in equal amounts. The drug is used as chewing substrate (chewing gum) within two weeks 3 times a day for 15 minutes after eating. To improve therapeutic effect is recommended within one hour of not eating.

The plants used are approved for use in the officinal medicine and are widely spread on the territory of the Russian Federation and, in particular, in Bashkiria. Extracts retain all the positive aspects of infusions and decoctions, and virtually no drawbacks and conserve natural resources. Use of extracts significantly expands the range of complex herbal remedies, because on their basis it is possible to prepare various dosage of medicines for internal and external use. In addition, technological approaches allow to obtain the extracts, containing in concentrated form the main biologically active substances, due to�which is determined by high pharmacological activity and their significant pharmacological effect in the relevant pathological conditions.

Beeswax is a solid granular substance secreted wax glands of young bees by eating their honey or pollen. It has more than 300 different compounds (esters, free fatty acids, hydrocarbons, water, flavorings, almost all macro - and micronutrients). In wax 13-15 free fatty acids, 12-17% are saturated hydrocarbon. Also contains carotenoids - 12,8 (4096 ME) in 100 g of wax, which is 400 times more than in carrots. Beeswax is recommended as a medicine anti-inflammatory, wound healing, astringent character that is used to cleanse the mouth and strengthening the mucous membranes.

therapeutic effect of chewing substrate is manifested by the fact that the chewing of the basis substrate contains beeswax, and as a dietary Supplement, extract, collect medicinal plants, consisting of the bark of oak-trees, grass Hypericum perforatum and creeping thyme (thyme), as well as the synergistic effect of its components. In addition, we suggest chewing the substrate does not contain synthetic polymers, which are undesirable for patients with LCP COP.

Used photosupload prepared as follows. Prepare the collection of a mass of 300 g of oak bark (Quercus robur), herb St. John's wort and herbs� creeping thyme (thyme). The raw material is taken in equal amounts (100 g each). Pour collect 3 liters of room temperature water and leave for days. In a day filled collection is extracted in a water bath to reflux during one hour. Then extracted, filtered and placed in a refrigerator. Further, this same raw pour 3 liters of 40% ethanol and left overnight. In a day filled collection is extracted in a water bath to reflux during one hour. Then extract, again filtered off and combined with water obtained earlier. Further, the combined extract was evaporated on water bath to obtain a thick extract, which is then injected into the melted wax and mix thoroughly. The resulting mass is poured into molds. In one chewable weighing 2 g contains 0.1 g of the extract (single dose).

The advantages of the proposed method of treatment are as follows:

1. Due to the use in the form of chewing gum is due to the prolongation of the action of medicinal substances.

2. Accelerate the time of treatment.

3. There are no systemic side effects.

5. The method is convenient and easy to use.

6. There are no negative reactions in patients.

The proposed method of local treatment used to treat 30 patients with lichen planus of the oral mucosa with various�bubbled forms, the control group consisted of 30 people of the same age without the LCP COP. The treatment efficiency was evaluated in the dynamics of subjective symptoms and clinical picture.

In this paper we study the dental status, determination of some biochemical parameters of oral fluid. Dental examination included medical history and complaints, external inspection, assessment of the state of dentition, oral mucosa, periodontal tissues. In oral fluid was determined the content of total protein, total calcium, phosphorus, magnesium (reagent kits "Vector-best") and TBA-active products (reagent kits "AGAT-MED") before and after the chewing of the substrate, consisting of 1.9 g of beeswax and 0.1 g of the extract of the collection of medicinal plants containing the bark of oak-trees, grass Hypericum perforatum and grass creeping thyme (thyme) in equal amounts. It was used as a chewing gum that caused the prolongation of the action of medicinal substances. Took 1 fitosanitario 3 times a day between meals for 2 weeks. Then again collected oral fluid.

In samples of mixed saliva was determined by the amount of calcium, magnesium, phosphorus, protein and TBA-active products. When you change the levels of calcium with 2,31±0,11 mmol/l to 1.64±0,12 mmol/l, magnesium from 0.48±0,07 mmol/l to 0.94±0,03 mmol/l, �of Ostra with 4,23±0,08 mmol/l to 5.05±0,15 mmol/l, protein with 2.38±0.12 g/l to 1.76±0.11 g/l, with a decrease of TBA-active products 3,38±0.02 to 2,37±0.01 the effectiveness of the treatment was evaluated as positive.

Protein in oral fluid in persons of the main group before the application of fitosanitaria were 2.38±0.12 µmol/l, after - 1,76±0,11 mmol/l (difference authentically p < 0,05); a control group of patients is 2.01±0.09 μmol/L. TBA-active products in the oral fluid in persons of the main group before the application of fitosanitaria amounted to 3.38±0,02, after - 2,37±0,01 (difference authentically p < 0,05); in the control group of patients the rate was equal to 2,15±0,01.

Calcium in the oral fluid in persons of the main group before the application of fitosanitaria amounted 2,31±0,11 mmol/l, after - 1,64±0,12 mmol/l (difference authentically p < 0,05); a control group of patients - 1,93±0,04 mmol/l Magnesium in oral fluid in persons of the main group before the application of fitosanitaria was 0.48±0,07 mmol/l, after - 0,94±0,03 mmol/l (difference authentically p < 0,05); a control group of patients - 0,72±0,02 mmol/l Phosphorus in the oral fluid in persons of the main group before the application of fitosanitaria amounted to 4.23±0,08 mmol/l, after - 5,05±0,15 mmol/l (difference authentically p < 0,05); the control group patients - a 4.53±0,11 mmol/l (table). Thus, the evaluation of the effectiveness of chewing substrate containing 1.9 g of beeswax and 0.1 g of the extract collection of medicinal plants, has a population�of boiling oak bark (Quercus robur), the herb St. John's wort and grass creeping thyme (thyme) in equal amounts, in the treatment of the LCP COP showed positive results.

Clinically this is manifested by the decrease and disappearance of inflammation in the mucosa of the mouth, flattening of the papules, reduce the time of epithelialization of erosions and ulcers, the normalization of the structural properties of the oral fluid of patients with LCP COP. Biochemical study of oral fluid showed an increase in phosphorus and magnesium, reduction of protein, calcium and TBA-active products.

The invention is illustrated by the following clinical example.

Patient I. turned to the dental clinic Manakin with complaints of tightness of the mucous membranes of the mouth, whitish education on the mucous membrane of the cheeks.

Objectively: the mucous membrane of the cheeks are gray-white papules coalesce in a whimsical pattern lace, buccal mucosa pale pink, painless on palpation.

Diagnosis: lichen planus is a typical form.

As local treatment was prescribed photosupload, consisting of 1.9 g of beeswax and 0.1 g of the extract of the collection of medicinal plants containing the bark of oak-trees, grass Hypericum perforatum and grass creeping thyme (thyme) in equal amounts 3 times a day for 14 days.

On day 9 was observed�again papules without signs of inflammation, flattened. After treatment, the patient no complaints, the mucous membrane of the mouth pale pink color with a single flattened papules.

Method of local treatment of lichen planus of the oral mucosa, which includes the use of herbal medicinal product containing extracts of collection of medicinal plants containing oak bark (Quercus robur) and the herb thyme, characterized in that the quality of the herbal medicinal product used chewing substrate containing 1.9 g of beeswax and 0.1 g of the extract collection of medicinal plants, additionally containing the herb St. John's wort and thyme grass creeping thyme (thyme) with an equal number of components of the collection, within two weeks 3 times a day for 15 minutes after eating.



 

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