Oral care product and methods for use and production thereof

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a two-phase mouth wash liquid and a method for use thereof. The disclosed two-phase mouth wash liquid contains a hydrophilic phase, a hydrophobic phase, a hydrotrope and a preservative, wherein the preservative contains (i) sodium benzoate and (ii) potassium sorbate and/or methylisothiazolinone (MIT), and the hydrotrope component contains glycerine and/or propylene glycol. The mouth wash liquid contains (a) 0.05-0.11 wt % sodium benzoate and (b) 0.05-0.2 wt % potassium sorbate and/or 0.0005-0.01 wt % MIT. The hydrophilic phase of the mouth wash liquid can additionally contain cetylpyridinium chloride in amount of 0.01-0.1 wt %, wherein the disclosed method of improving oral health includes using an effective amount of said liquid in the mouth of a subject to reduce the level of cariogenic bacteria.

EFFECT: use of said combination of preservatives coupled with said hydrotrope provides good resistance to microbial contamination without any adverse effect on taste properties or appearance of the mouth was liquid.

12 cl, 1 ex

 

The technical field to which the invention relates

The present invention relates to mixtures of preservatives for compositions of two-phase liquid mouthwash, containing (i) a hydrophilic phase containing hydrotap, (ii) a hydrophobic phase and (iii) a preservative selected from Methylisothiazolinone, sodium benzoate and potassium sorbate, and combinations thereof, as well as to methods of application and receipt of such compositions.

The prior art prior to the invention

Due to the high water content in liquids for rinsing of a mouth there are specific problems preventing microbial contamination. Specific problems of two-phase fluids mouthwash are that the hydrophilic and hydrophobic phases must remain separate from each other condition to form an unstable emulsion when mixed. Emulsion spontaneously goes back into the two original phases at rest without the formation of emulsions. See, for example, the publication of U.S. patent 20090311200, the content of which is incorporated into this description by reference. The choice of preservative, which is effective and which does not affect the physical properties of the two-phase composition is not Prime. In addition, some preservatives adversely affect the taste or aesthetic properties of the product. Finally, conventional means, such kkkonservative-based ethanol and parabens, may be undesirable for certain indicators or for specific markets.

Thus, there is a need to identify improved preservatives for use in two-phase fluids mouthwash.

Brief description of the invention

Now unexpectedly discovered that a two-phase liquid mouthwash, containing (i) a hydrophilic phase containing hydrotap, (ii) a hydrophobic phase and (iii) a preservative selected from the combinations of (a) sodium benzoate and (b) Methylisothiazolinone and/or potassium sorbate and combinations thereof, are stable and effective.

Thus, the invention relates to compositions for caring for the oral cavity and methods of their use that are effective in suppressing or reducing the accumulation of plaque, lower levels kislotoproduktsiya (cariogenic) bacteria, remineralizing teeth and in the suppression or reduction of gingivitis. The invention also relates to compositions and methods for the cleansing of the oral cavity and provide improved methods of maintaining the health of the oral cavity and/or General health, including the health of the cardiovascular system, for example, by reducing the total probability of infection through the tissues of the mouth.

Thus, the invention relates to a liquid composition for Polo�Kania mouth (the composition of the invention), containing hydrophilic phase containing hydrotap, (ii) a hydrophobic phase and (iii) a preservative, where the preservative comprises (a) sodium benzoate and (b) Methylisothiazolinone and/or potassium sorbate.

The composition of the invention may contain additional ingredients, for example selected from one or more of water, surfactants, solvents, vitamins, minerals, polymers, enzymes, humectants, thickeners, additional antimicrobial agents, additional flavorings, colorings and/or combinations thereof. In specific embodiments, the invention may include means against the formation of dental calculus, such as polyphosphate, such as pyrophosphate, tripolyphosphate or hexametaphosphate, for example, in the form of alkali metal salts, for example sodium or potassium, and/or may contain synthetic anionic polymeric PCE, such as copolymers of 1:4 to 4:1 of maleic anhydride or acid with another polymerizable ethyleneamines monomer, e.g. a copolymer of methyl vinyl ether/maleic anhydride.

In the present description describes an effective amount of preservatives in the compositions according to the invention, separately or together comprise, for example, as described below, mass: MIT less than 0.1%, for example 0,0005-0,1%, for example of 0.001%, 0.01% or 0.05 percent; Ben�oat of sodium less than 1%, for example 0.1 to 0.5%, for example 0,11% or 0.44 percent; potassium sorbate less than 1%, for example 0,05%-0,5%, such as 0.1%.

The invention further relates to methods comprising applying compositions effective for use in the oral cavity, such as the rinsing of the oral cavity, optionally in combination with brushing, to (i) reduce or inhibit formation of dental caries, (ii) the reduction or inhibition of demineralization and activation remineralization of the teeth, (iii) reduce hypersensitivity of the teeth, (iv) reduction or suppression of gingivitis, (v) accelerate the healing of wounds or cuts in the mouth, (vi) reduce the levels kislotoproduktsiya bacteria, (vii) to increase relative levels alginolyticus bacteria, (viii) inhibiting the formation of microbial biofilms in the oral cavity, (ix) improve and/or maintain the pH of dental plaque at levels of at least pH 5.5 after exercise sugar, (x) reduce plaque accumulation, (xii) treat, mitigate or reduce dry mouth, (xii) clean the teeth and oral cavity, (xiii) reduce erosion, (xiv) whiten teeth, (xv) immunize the teeth against cariogenic bacteria; and/or (xvi) maintain General health, including the health of the cardiovascular system, for example, by reducing the total probability of infection through the tissues of the mouth.

Detailed description of the invention/p>

Thus, in the first variant implementation of the invention relates to two-phase liquid mouthwash (song 1.0) containing a hydrophilic phase containing hydrotap, a hydrophobic phase and a preservative, where the preservative contains (i) sodium benzoate and (ii) a sorbate and/or Methylisothiazolinone and where the liquid mouthwash contains (a) 0.05 to 0.05% of sodium benzoate and (b) 0.05 to 0.2% of potassium sorbate and/or 0.0005-0.01% of MIT.

For example, any of the following songs:

1.0.1. The composition is 1.0, where the hydrophobic and hydrophilic phases spontaneously separated after mixing of the phases and essentially do not form an emulsion at room temperature for one hour after mixing.

1.0.2. Any of the above compositions, where hydrotropic component of the hydrophilic phase contains a polyglycol, a polyhydric alcohol or a mixture thereof.

1.0.3. Any of the above compositions, where hydrotropic component contains ethylene glycol, propylene glycol, glycerin, diethylene glycol, dipropyleneglycol, tripropyleneglycol, xianglian, 1,3-butyleneglycol, 1,4-butyleneglycol, 1,2,6-hexanetriol, sorbitol, xylitol, or a combination.

1.0.4. Any of the above compositions, where hydrotropic component contains glycerin and/or propylene glycol.

1.0.5. Any of the above compositions, where hydrotropic component contains sorbitol.

1.0.6. Any �W the above compositions where the hydrophobic phase contains an oil selected from isopropylmyristate, mineral oil, edible oil and their combinations.

1.0.7. Any of the above compositions containing from 1% to 90% by volume of the hydrophilic phase.

1.0.8. Any of the above compositions with the mass ratio of hydrophobic phase to hydrophilic phase 15:85.

1.0.9. Any of the above compositions, where the hydrophilic phase contains hydrotropic component.

1.0.10. Any of the above compositions, which essentially does not contain cationic surfactants.

1.0.11. Also in the present description describes the composition, where preservatives are held separately or together in quantities by mass: MIT less than 0.1%, for example 0,0005-0,1%, for example of 0.001%, 0.01% or 0.05 percent; sodium benzoate less than 1%, for example 0.1 to 0.5%, for example 0,11% or 0.44 percent; potassium sorbate less than 1%, for example 0,05%-0,5%, such as 0.1%.

1.0.12. The above composition where the preservative contains sodium benzoate.

1.0.13. The above composition where the preservative contains sodium benzoate and potassium sorbate.

1.0.14. The above composition containing (i) 0,05%-0,5% sodium benzoate and (ii) of 0.05%-0,2% potassium sorbate and/or 0.0005%-0,01% MIT.

1.0.15. Any of the above compositions, where the hydrophilic phase further comprises cetylpyridinium chloride, for example, in an amount of 0.01-0.1%, for example, 0.05%.

1.0.16. Any of the above to�positions where the hydrophilic phase further contains an acid, for example an organic acid such as citric acid.

1.0.17. Any of the aforementioned compositions, further comprising means against the formation of dental calculus, such as polyphosphate, e.g., pyrophosphate, tripolyphosphate or hexametaphosphate, for example, in the form of a salt, e.g. the sodium or potassium salt, for example, in an amount of 0.1-3%.

1.0.18. The above composition, where the tool against the formation of Tartar is a pyrophosphate selected from tetrasodium pyrophosphate and tetrapropoxide potassium and mixtures thereof.

1.0.19. The above composition containing from 0.1 to 1% of tetrasodium pyrophosphate and 1-2% of tetrapropoxide potassium, for example 0.25 to 0.75% tetrasodium pyrophosphate, and 1.0-1.5% of tetrapropoxide potassium.

1.0.20. Any of the above compositions containing at least one polymer selected from polyethylene glycols, synthetic anionic polymeric polycarboxylate, such as copolymers polivinilovogo ether maleic acid, polysaccharides (e.g., cellulose derivatives such as carboxymethyl cellulose, or polysaccharide gums, for example xanthan gum or carrageenan), and their combinations.

1.0.21. Any of the above compositions containing a synthetic anionic polymeric PCE, e.g.�measures in the amount of 1-10%, for example, 2.5 to 7.5%.

1.0.22. The above composition, in which the synthetic anionic polymeric PCE is a copolymer of 1:4 to 4:1 of maleic anhydride or acid with another polymerizable ethyleneamines monomer, for example methyl vinyl ether/maleic anhydride, having a molecular weight (M. M.) from 30000 to 5000000 daltons, for example 1000 kDa to 3000 kDa.

1.0.23. The above composition containing the copolymer of methyl vinyl ether/maleic anhydride with the General structure -[-CH2-CH(OCH3)-CH(COOH)-CH(COOH)-]-n, viscosity CP @ 25ºC 1-3 of the PCB, for example, of 1.7×103JV, and the nominal molecular weight of 1000 kDa to 3000 kDa, for example of 1.98×106for example , the amount by weight of 1-10%, e.g. 5%.

1.0.24. Any of the above compositions, which does not contain ethanol.

1.0.25. Any of the above compositions, optionally containing a basic amino acid in free form or in salt form, e.g., arginine, e.g., in an amount of 0.1-3%, for example, of 0.8%.

1.0.26. Any of the above compositions, optionally containing a soluble calcium salt, for example selected from the glycerophosphate of calcium, and soluble salts of carboxylic acids and their mixtures, for example, where a calcium salt selected from calcium citrate, calcium malate, calcium lactate, calcium formate, calcium fumarate, gluconate� calcium gluconate calcium lactate, calcium aspartate, and calcium propionate, and mixtures thereof.

1.0.27. Any of the preceding compositions, optionally containing a source of fluoride, such as fluoride salt, for example sodium fluoride, or fluoride is covalently bonded to another atom, such as monofluorophosphate, for example, sodium monofluorophosphate, forcelimit, such as forcricket sodium or forcricket ammonium, or persulfate, such as hexapetala, amintore, and combinations thereof.

1.0.28. The earlier composition, in which the fluoride salt is contained in amount to provide from 100 to 250 M. D. available fluoride.

1.0.29. Any of the preceding compositions containing sodium fluoride in the amount of 0.01-0.1%, such as 0.05 percent.

1.0.30. Any of the preceding compositions where the pH is in the range from 5 to 6.5, such as the 5.5.

1.0.31. Any of the preceding compositions, optionally containing an abrasive substance, or particles.

1.0.32. Any of the preceding compositions comprising a nonionic surfactant, e.g. in an amount of 0.5-5%, for example 1-2%, selected from poloxamers (e.g. poloxamer 407), polysorbates (e.g., Polysorbate 20), polyoxyl hydrogenated castor oil (e.g., polyoxyl 40 hydrogenated castor oil) and mixtures thereof.

1.0.33. Any of the preceding compositions, �tereasa at least one humidifier.

1.0.34. Any of the preceding compositions containing at least one humectant selected from glycerin, sorbitol, propylene glycol and their combinations, for example, in the total amount of 10-40%.

1.0.35. Any of the preceding compositions containing polymeric film.

1.0.36. Any of the preceding compositions containing fragrance, perfume and/or dye.

1.0.37. Any of the preceding compositions containing at least 50% water.

1.0.38. Any of the preceding compositions comprising an antibacterial agent selected from halogenated simple diphenyl ether (e.g. triclosan), herbal extracts and essential oils (e.g. rosemary extract, tea extract, Magnolia extract, thymol, menthol, eucalyptus, geraniol, carvacrol, citral, hinokitiol, catechol, methyl salicylate, EGCG, EGCG, Galic acid, extract of miswak, extract of sea buckthorn (Hippophae rhamnoides), biguanidines antiseptics (e.g., chlorhexidine, alexidine or octenidine), Quaternary ammonium compounds (e.g., cetylpyridinium chloride (CPC), benzalkonium chloride, the chloride tetradecylbenzene (TPC), chloride N-tetradecyl-4-ethylpyridine (TDEPC)), phenolic antiseptics, hexetidine treatment, octenidine, sanguinarine, povidone-iodine, delmopinol, soliflore, other metal ions (e.g., zinc salts, �of primer zinc citrate, salts of tin, copper salts, iron salts), sanguinarine, propolis and oxidizing agents (e.g. hydrogen peroxide, buffered peroxyborate or peroksikarbonat), phthalic acid and its salts, nonoperatively acid and its salts and esters, ascorbinsaeure, oleoresin, alkylsulfate, dioctylsulfosuccinate, salicylanilide, domiphen bromide, delmopinol, Octafinal and other derivatives piperidino, drugs Nizina, salts of hydrochloric acid and mixtures of any of the above compounds.

1.0.39. Any of the preceding compositions comprising an antioxidant, e.g., selected from the group consisting of coenzyme Q10, PQQ, vitamin C, vitamin E, vitamin A, anethole-ditation and mixtures thereof.

1.0.40. Any of the preceding compositions comprising a bleaching agent.

1.0.41. Any of the preceding compositions comprising a bleaching agent selected from a whitening active substances selected from the group consisting of peroxides, metal chlorite, perborates, percarbonates, peroxyketal, hypochlorite and combinations thereof.

1.0.42. Any of the preceding compositions further comprising hydrogen peroxide or a source of hydrogen peroxide such as urea peroxide or a peroxide salt or complex (e.g., such as peroxyformic, peroxocarbonate, perborate, peroxyacyl�cat or a persulfate salt, for example, proxyport calcium, sodium perborate, peroksikarbonat, peroxyborate sodium and potassium persulfate) or polymeric complexes of hydrogen peroxide, such as polymeric complexes of hydrogen peroxide-polyvinylpyrrolidone.

1.0.43. Any of the preceding compositions, optionally containing an agent that inhibits or prevents the attachment of bacteria, for example Cabral or chitosan.

1.0.44. Any of the preceding compositions, optionally containing a physiologically acceptable potassium salt, e.g. potassium nitrate or potassium chloride, in an amount effective to reduce tooth sensitivity.

1.0.45. Any of the preceding compositions comprising from 0.01% to 1% of a physiologically acceptable potassium salt, such as potassium nitrate and/or potassium chloride.

1.0.46. Any of the preceding compositions effective upon application to the oral cavity, such as when rinsing, optionally in combination with brushing, to (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or suppression precariously damage to the enamel, e.g., as diagnosed by quantitative secondarywindow fluorescence (QLF) or the definition of caries from the electric resistance (ECM), (iii) a decrease or inhibition of demineralization and activation remineralization of the teeth, (iv) reducing�Oia hypersensitivity of the teeth, (v) reduction or suppression of gingivitis, (vi) promote healing of wounds or cuts in the mouth, (vii) reduce levels kislotoproduktsiya bacteria, (viii) to increase relative levels alginolyticus bacteria, (ix) inhibit the formation of microbial biofilms in the oral cavity, (x) raise and/or maintain the pH of dental plaque at levels of at least pH 5.5 after exercise sugar, (xi) reduce plaque accumulation, (xii) treat, mitigate or reduce dry mouth, (xiii) cleaning of the teeth and oral cavity, (xiv) reduce erosion, (xv), prevention of staining and/or bleaching of the teeth, (xvi) immunize the teeth against cariogenic bacteria; and/or (xvii) maintain General health, including the health of the cardiovascular system, for example, by reducing the total probability of infection through the tissues of the mouth.

1.0.47. The composition is obtained or obtainable by combining the ingredients as described above in any of the preceding compositions.

The levels of active ingredients vary depending on the nature of the delivery system and specific active substances. For example, the zinc salt may be contained at levels, for example, from 0.05 to 2 wt.%, for example, from 0.1 to 1 wt%. Fluoride may be contained at levels, for example, from 25 to 250 M. D. or to levels 10 times higher for professional or over R�zepto means of therapeutic and prophylactic use. Levels of Antibacterials varies similarly depending on the means used. For example, the means for rinsing the mouth on the basis of triclosan may contain, for example, of 0.03% of the mass. triclosan.

In another embodiment of the present invention relates to a method for improving the health of the oral cavity, comprising applying an effective amount of an oral composition of any of the embodiments as described above, in the mouth of the needy in this subject, for example, the method is:

i. reducing or inhibiting the formation of dental caries,

ii. reduce, restore or suppress precariously damage to the enamel, e.g., as diagnosed by quantitative secondarywindow fluorescence (QLF) or the definition of caries from the electric resistance (ECM),

iii. reduction or inhibition of demineralization and activation remineralization of the teeth,

iv. reduce hypersensitivity of the teeth,

v. reduction or suppression of gingivitis,

vi. accelerate healing of wounds or cuts in the mouth,

vii. inhibiting the formation of microbial biofilms in the oral cavity,

viii. improving and/or maintaining the pH of dental plaque at levels of at least pH 5.5 after exercise sugar,

ix. reduce the accumulation of plaque,

x. treatment of dry mouth,

xi. us�tion of General health, including the health of the cardiovascular system, for example, reduce the total probability of infection through the tissues of the mouth,

xii. teeth whitening,

xiii. reduce erosion of the teeth,

xiv. immunization (or protect) the teeth against cariogenic bacteria and their actions and/or

xv. clean teeth and oral cavity.

The invention further relates to the application of any of Methylisothiazolinone, sodium benzoate, potassium sorbate and combinations thereof upon receipt of the compositions according to the invention, for example, for use in any of the above indications of the above.

The compositions of the present invention contain hydrophilic and hydrophobic phase and hydrotropic component, which when mixed form an unstable emulsion of "oil-in-water" that breaks up and splits back into hydrophobic and hydrophilic phases in a period of from 5 seconds to one hour after mixing. Unexpectedly found that the separation of the hydrophilic and hydrophobic phases is complete, for example, without the existence of the emulsion between the two phases. Without wanting to be bound by theory, believe that the high HLB hydrophobic phase provides complete separation of the two phases.

The hydrophobic phase of the composition according to the present invention may include any orally acceptable hydrophobic liquid, for example, generally recognized as safe�ing. Such substances are known in this field and may include isopropyl myristate, paraffin oil (mineral oil), edible oils, such as olive oil, corn oil, coconut oil, soybean oil, and combinations thereof. Preferred hydrophobic phase contains paraffin oil, isopropyl myristate. Preferably the hydrophobic phase has an HLB of from 7 to 12, for example 10.

The hydrophilic phase of the compositions of the present invention mainly consists of water, for example, contains from 40% to 95% by weight of water. Other suitable substances may also include orally acceptable alcohols, moisturizers, or polymers. Humidifier in terms of pure humidifier typically ranges from 10% to 50% in one of the embodiments or from 15% to 25% in another embodiment, the implementation by weight of composition of a liquid mouthwash. The hydrophilic phase may optionally contain one or more polymers in the hydrophilic phase, such as copolymers polivinilovogo ether maleic acid, polysaccharides (e.g., cellulose derivatives, e.g., carboxymethyl cellulose, or polysaccharide gums, for example xanthan gum or carrageenan). The compositions of the present invention can contain an orally acceptable copolymer polivinilovogo ether/maleic anhydride (PVME/MA). Copolymer PVME/MA�kept from 0.1% to 20%, for example, from 0.5% to 10% by mass. Typically, the ratio of methyl vinyl ether to maleic anhydride in the copolymer is from 1:4 to 4:1, and the average molecular weight of the copolymer is from 30,000 to 1,000,000, for example from 30000 to 500000. Preferred copolymers PVME/MA such as under the trademark GANTREZ from ISP (Wayne, N. J.). Copolymer PVME/MA can also act as an antibacterial enhancing agent, if contained in an antibacterial enhancing effective amount.

Hydrotropic known in this field and include compounds that enhance the solubility of hydrophobic compounds in aqueous solutions. Hydrotropic represent a low molecular weight amphiphilic compounds that are similar to surfactants because they contain hydrophilic groups and which can be described from the point of view of surface-active substances such as low molecular weight hydrophobic substance. The hydrophilic group may be attached to an organic functional group, which is too short a group to give these surface-active properties. Suitable in the present invention hydrotropic may include aromatic sulfonates, aromatic phosphate esters, di - and polycarboxylate, polyglycols and alcohols, including polyhydric alcohols. The HLB value is suitable in n�standing of the invention hydrotropes is from 7 to 18. Despite the fact that any hydrotap may be suitable in the present invention (preferably GRAS), hydrotap may have a HLB value of similar hydrophobic phase, and, thus, usable in the compositions hydrotap will depend on the composition of the hydrophobic phase. Preferably HLB linking system is higher than the HLB of the hydrophobic phase, e.g., 10%, 15%, 20% or 30% higher than the HLB of the hydrophobic phase. Methods for determining the HLB is well known to specialists in this field. Hydrotropic component in the present invention contains one or more polyglycols and/or polyhydric alcohol, preferably a diol and/or triol. Preferably, the binding system contains glycerin and propylene glycol. The exact ratio of glycerol to propylene glycol in linking the system will depend on the desired HLB hydrotropes component of the present invention. Due to the fact that hydrotropes missing properties of the surfactant, the dispersion of the oil phase in the water is not thermodynamically stable, obtained by mixing the two phases, the emulsion is transferred back to the separate and different phase immediately after mixing.

The compositions of the present invention contain one or more surfactants, which are known in this field. Suitable surface-active prophetic�include STV, which are reasonably stable throughout a wide pH range, for example anionic, cationic, nonionic or zwitterionic surfactants. Preferred surfactants are nonionic surfactants. Preferably the amount of surfactant in the compositions of the present invention is reduced to minimize dispersion of the hydrophobic phase in hydrophilic phase in the formation of emulsions that are not separated within 2 minutes after mixing of the phases. Unexpectedly it was found that minimizing the content of the surfactant and the presence of hydrotropes provide effective separation of the two phases. In one embodiment of the present invention, oral compositions contain no or essentially does not contain surfactants, in particular anionic, cationic and zwitterionic surfactants. In the present invention can be used nonionic surfactants in limited quantities. Such nonionic surfactants can be defined as compounds produced by the condensation reaction alkalinising groups (hydrophilic in nature) with an organic hydrophobic compound, which may be aliphatics�m alkyl or by nature. Examples of suitable nonionic surfactants include, but are not limited to, pluronic, condensation products of polyethylene oxide and alkyl phenols, products obtained by condensation of ethylene oxide and the reaction product of propylene oxide and ethylene diamine, condensation products of ethylene oxide and aliphatic alcohols, oxides, long chain tertiary amine oxides, long chain tertiary phosphine, a long-chain diallylsulfide and mixtures of such substances. The compositions of the present invention may contain from 0.0001% to 0.01% by weight of a surfactant.

The composition of the invention are intended for topical application in the oral cavity, and, thus, the salts for use in the present invention should be safe for such use provided in quantities and concentrations. Suitable salts include salts, for which in this area it is known that they are pharmaceutically acceptable salts, for which, as a rule, suggest that they are physiologically acceptable in the envisaged quantities and concentrations. Physiologically acceptable salts include salts derived from pharmaceutically acceptable inorganic or organic acids or bases, such as additive, acid salts formed by acids which obra�comfort physiologically acceptable anion, for example hydrochloride or bromide salt, and additive salts of the bases formed with bases which form a physiologically acceptable cation, for example, such as those derived from alkali metals such as potassium and sodium or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts may be well-known in the field of conventional ways, such as the interaction is sufficiently basic compound such as an amine with a suitable acid, providing a physiologically acceptable anion.

The source of fluoride ion. The oral composition may further contain one or more sources of fluoride ions, e.g., soluble fluoride salts. As sources of soluble fluoride in the present compositions can be applied to a wide range of substances, giving the fluoride ion. Examples of suitable substances, giving the fluoride ion can be found in U.S. patent No. 3535421 addressed to Briner et al., U.S. patent No. 4885155 addressed to Parran Jr. et al. and U.S. patent No. 3678154 addressed to Widder et al., included in this description by reference. Typical sources of fluoride ion include, but are not limited to, tin fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, forcricket sodium, forcricket ammonium, amine fluoride, ammonium fluoride, and combinations thereof. In certain embodiments, the IP�full-time for fluoride include fluoride tin, sodium fluoride, sodium monofluorophosphate, and mixtures thereof. If the composition contains calcium salts, fluoride salts preferably are salts where the fluoride is covalently bonded to another atom, such as sodium monofluorophosphate, unlike a simple ionic bond, for example, sodium fluoride.

Flavors

Compositions for caring for the oral cavity according to the invention may also contain flavoring. The flavors that are used in the practical implementation of the present invention include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and similar substances, as well as sweeteners, such as saccharin sodium. Examples of essential oils include oil curly mint, peppermint, Wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit and orange. Also useful are such chemicals as menthol, carvone, and anethole. In certain embodiments, use of peppermint oil and mint crispy.

Flavor is contained in the oral composition at a concentration of from 0.01 to 1% by mass.

Chelating means and means against the formation of Tartar

Compositions for caring for the oral cavity according to the invention may also optionally contain one or more hela�arousih funds forming complexes with calcium in the cell walls of bacteria. The binding of such calcium weakens the cell wall of bacteria and increases the lysis of bacteria.

One of the groups of means, suitable for use as chelating funds or funds against the formation of plaque in the present invention is a soluble pyrophosphates. Used in the present compositions propogate salt can be any kind pyrophosphate alkali metal salts. In certain embodiments, salts include tetrapyrrolic alkali metal, dukely deerfoot alkali metal, acid tapirisat alkali metal and mixtures thereof, where the alkali metals are sodium or potassium. Salts suitable for use both in hydrated and non hydrated forms. An effective amount of pyrophosphate salt useful in the present composition, generally sufficient for the formation of at least 0.5% by weight. pyrophosphate ions, 0.9 to 3% of the mass.

These compounds also contribute to the preservation of compositions by lowering water activity.

Enzymes

Compositions for caring for the oral cavity according to the invention may also optionally contain one or more enzymes. Suitable enzymes include any of the available proteases, glucanohydrolase, endoglin�of sides, amylase, mutans, lipase and Mucins or their compatible mixtures. In certain embodiments, the enzyme is a protease, dextranase, endoglycosidase and athanasou. In another embodiment of the enzyme is a papain, endoglycosidase or a mixture of dextranase and atanazy. Additional enzymes suitable for use in the present invention are described in U.S. patent No. 5000939 in the name Dring et al., U.S. patent No. 4992420, U.S. patent No. 4355022, U.S. patent No. 4154815, U.S. patent No. 4058595, U.S. patent No. 3991177 and U.S. patent No. 3696191 included in this description by reference. The enzyme mixture of several compatible enzymes in the present invention is from 0.002% to 2.0%, in one embodiment, implementation, or from 0.05% to 1.5% in another embodiment, implementation, or in another embodiment, the implementation of from 0.1% to 0.5%.

Water

In the oral compositions according to the invention contains water. The water used in the commercial oral compositions must be deionized and not contain organic impurities. Water is usually of the composition is adjusted to the final volume, and it ranges from 10% to 90%, for example, from 40% to 70% by weight of the oral compositions. This amount of water includes the free water which is added plus that amount which is introduced with other materials such as with sorbitol and�and all components according to the invention.

Humidifiers

In certain embodiments, oral compositions also preferably enter the humidifier to reduce evaporation and ensure conservation by lowering water activity. Certain humectants can also impart desirable romantic rogue or fragrance compositions. Humidifier in terms of pure humectant generally comprises from about 15% to 70% in one of the embodiments or from 30% to 65% in another embodiment, the implementation by weight of the composition.

Suitable humectants include edible polyhydric alcohols such as glycerin, sorbitol, xylitol, propylene glycol, and other polyols and mixtures of these humectants. In certain embodiments, it is possible to use a mixture of glycerin and sorbitol as a component of the humidifier of the compositions according to the present description.

The present invention in the aspect of its method relates to the use in the oral cavity safe and effective amounts described in the present description of the compositions.

Compositions and methods according to the invention is suitable for a way to protect the teeth by facilitating recovery and remineralization, in particular to reduce or inhibit the formation of dental caries, reduce or inhibit the demineralization and activation remineralization of the teeth, reduce hyperc�stateliest teeth and reduction, recovery or suppression of early lesions of the enamel, e.g., as diagnosed by quantitative secondarywindow fluorescence (QLF) or the definition of caries from the electric resistance (ECM).

Improving the health of the mouth also has a beneficial effect on General health, because the tissues of the mouth can be a gateway for other infections. Good oral health is connected to overall health, including healthy cardiovascular system. Compositions and methods according to the invention, therefore, used to improve overall health, including the health of the cardiovascular system.

As used throughout, ranges are used as a shorthand for describing each and every part of the range values. Any value in the range can be selected as the final value of the range. In addition, all cited in the present description reference is fully included, therefore, by reference. In case of discrepancies in the description in the present description and the description, cited references, the present description shall take precedence. It should be understood that when describing the compounds, they can be described in terms of their ingredients, as is common in this area, although these ingredients can re�to hirawat with each other in the present composition when it is received, the storage and application, and imply that the described formulations include such products.

The following examples further describe and demonstrate illustrative embodiments of within the scope of the present invention. Examples are given for illustration only and should not be interpreted as limitations of the present invention, as many changes are possible without deviation from the essence and scope of the present invention. Various modifications of the invention addition to those shown and described in the present description, will be obvious to specialists in this field and are included in the attached claims.

Example 1 - Liquid mouthwash

The compositions of the invention prepared using the following ingredients, mass percentages given in relation to the end of the two-phase composition:

Ingredients

Phase a (hydrophobic)Phase b (hydrophilic)
Glycerin-7,5
Mineral m�slo 12-
Sodium fluoride-0,05
Sarahin sodium-0,08
Citric acid anhydrous-0,01
Monophosphate anhydrous sodium-0,05
Surfactant-0,1
Flavoring1,1-
Dye0,000120,004
Potassium sorbate-0,1
Sodium benzoate-0,11
The cetylpyridinium chloride-0,05
Water-to 100
pH not measured5,5

To optimise the mixture of different preservatives preservatives are replaced by potassium sorbate and/or sodium benzoate in the above composition, and properties of the composition were tested for antimicrobial efficacy hydrophilic phase, impact on the taste and effect on the aesthetic properties.

To determine the antimicrobial efficacy of the compositions of the products on the basis of water used the test for antimicrobial preservative effectiveness, such as a test with double pollution. Products develop as a stable to microbial contamination introduced during normal use by the consumer. The test is subjected to aging samples (13 weeks, 40ºC). In the test used two sets of microorganisms: bacteria/yeast and mold fungi. Product pollute at 1% on 0 day and on the 7th day. For inoculum reduction observed during the period of 28 days. Below are the acceptable criteria for the composition of a liquid for rinsing of a mouth.

For bacteria and yeast need to show a 99.9% reduction (3 log). bacterial inoculum, as determined by determining the number of bacteria seeding for 7 days after each inoculation. Did not notice any increase on day 7 after the second inoculation and during the remaining duration of the test within the norm�the diesel variation of the data.

- For mold need to show 90,0% reduction (1 log). fungi inoculum, as determined by determining the number of bacteria by inoculation 14 days after the second inoculation (21 days). Did not notice any increase from 14 days to 21 days second inoculation test within the normal variation of the data.

Flavor evaluated by organoleptic evaluation specialists in food flavorings.

Aesthetic features are estimated by visual comparison of a control sample containing the same type and levels of dye and flavorings.

The results of the comparative test are as shown below, where "V" indicates the presence of the criterion and "X" means no criterion.

PreservativeBenzoate Na at 0,44%Benzoate Na when 0,11%Benzoate Na 0,11%/K sorbate 0,1%0,11% Na/0,001% MIT
Resistance to microbesVXVV
Efficacy in vitroVVV V
Impact on the tasteXVVV
Impact on aesthetic propertiesVVVV

Sodium benzoate alone was an acceptable microbiological control on 0,44%, but this level has had an adverse impact on the taste. When the amount of sodium benzoate was reduced, the level of resistance to microbes decreased. The perfect part was the combination of sodium benzoate when 0,11% with low levels of potassium sorbate (0.1 per cent) or Methylisothiazolinone (MIT) (0,001%) who possessed good antimicrobial efficacy without adversely affecting the taste or appearance of the product.

1. Two-phase liquid mouthwash containing a hydrophilic phase, a hydrophobic phase, hydrotap and preservative,
where the preservative contains (i) sodium benzoate and (ii) a sorbate and/or Methylisothiazolinone (MIT), where the liquid mouthwash contains (a) 0.05% of the mass. - 0,11% wt. sodium benzoate and (b) 0,05% of the mass. To 0.2 wt%. potassium sorbate and/or 0.0005% of the mass. - 0,01% of the mass. MIT,
and where hydrotropic component contains glycerin and/or propylene glycol.

2. Liquid mouthwash according to claim 1, g�e hydrophobic phase contains oil, selected from isopropylmyristate, mineral oil, edible oil and their combinations.

3. Liquid mouthwash according to claim 1, wherein the hydrophilic phase contains hydrotropic component.

4. Liquid mouthwash according to claim 1, wherein the hydrophilic phase further comprises cetylpyridinium chloride in an amount of 0.01 to 0.1% of the mass.

5. Liquid mouthwash according to claim 1, further comprising pyrophosphate.

6. Liquid mouthwash according to claim 1, further comprising a synthetic anionic polymeric PCE.

7. Liquid mouthwash according to claim 1, further comprising a source of fluoride ion.

8. Liquid mouthwash according to claim 1, which contains ethanol.

9. Liquid mouthwash according to claim 1, further comprising one or more humectants, flavors, and surfactants.

10. Liquid mouthwash according to claim 1, wherein the preservative is contained in a hydrophilic phase in an effective amount.

11. A method of improving the health of the oral cavity, comprising applying an effective amount of a liquid for rinsing of a mouth according to claim 4 in the oral cavity in need of a subject to reduce the level of cariogenic bacteria.

12. Two-phase liquid mouthwash according to claim 4 for use in the method of reducing the level of cariogenic bacteria.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to 5-benzyl-1,3-diazaadamantan-6-one derivatives of formula , where X is hydrogen (1a), methoxyl (1c) substitutes.

EFFECT: obtaining novel fragrant 5-benzyl-1,3-diazaadamantan-6-ones, which can be used in perfume compositions, as medicinal substances, repellents and as starting substances for producing novel 1,3-diazaadamantan derivatives.

6 ex

FIELD: chemistry.

SUBSTANCE: composition of preparation for teeth cleaning contains effective quantity of arginine in free form or in form of salt; abrasive substance, containing (i) natural sodium carbonate (NSC) with the average size of particles 3-7 mcm and moisture absorption 12-25 g/100 g and (ii) precipitated calcium carbonate (PCC) with the average particle size 1-5 mcm and water absorption higher than 25 g/100 g. Ratio of natural calcium carbonate to precipitated calcium carbonate constitutes from 1:2 to 1:3. Composition has pellicle cleaning ratio (PCR), at least, 70 and value of abrasivity of isotope-labelled dentin (RDA) lower than 140. Method of oral cavity care includes application of effective quantity of said composition in oral cavity of individual requiring it.

EFFECT: effective teeth cleaning and strengthening without injuring abrasive action, which makes it possible to apply it, in particular, for individuals with increased teeth sensitivity.

13 cl, 2 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: composition contains a) surface-active substances, including a salt of C10-16 alcohol ethoxylate sulphate, a betaine surface-active substance and alkylpolyglicoside, and b) a fatty C12-18 acid, constituting at least 15% of the total composition weight.

EFFECT: composition, possessing an increased viscosity and capable of producing a stable foam, is created.

10 cl, 1 tbl, 4 ex, 2 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine, particularly to cosmetology, and describes a method for stabilising an anhydrous antiperspirant composition involving: (a) preparing a mixture of at least one substance having the antiperspirant action, containing a metal salt, and an anhydrous carrier for at least one substance possessing the antiperspirant action, wherein dissolved is at least one substance having the antiperspirant action, a carrier containing an eutectic mixture of carbamide and trimethylglycine; (b) heating this mixture for preparing the eutectic mixture of at least one substance having the antiperspirant action, and the anhydrous carrier.

EFFECT: invention can be used to reduce the body perspiration; the compositions can be applied by hands or with a package.

22 cl, 3 dwg, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a compound of formula such as below , wherein Z is oxygen; Y is hydrogen or a sequence as follows: -O-C(R4)-V-(C=O)-R5; V is oxygen; R1 and R4 are identically or independently hydrogen or a C1-4 alkyl; R2 and R5 are identically or independently a C1-10 alkyl.

EFFECT: these compounds can be applicable in therapy for treating pathologies or disorders related to the presence of Propionibacterium acnes, eg acne-like skin disorders.

5 cl, 2 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed is emulsified composition for improvement of skin condition, which contains (A) 0.001-10 wt % of organic compound, which has two or more hydroxyl groups, inorganic value 220-450 and organic value 300-1000; (B) 0.001-10 wt % of organic compound, which has one hydroxyl group, inorganic value 100-200 and organic value 280-700; (C) 0.001-10 wt % of organic substance, represented by formula (2), in which R1 is C4-C30 hydrocarbon group; Z is methylene group, methane group or oxygen atom; X1, X2, X3 are hydrogen atom, hydroxyl group or acetoxy group; X4 is hydrogen atom, acetyl group or glyceryl group; each of R2 and R3 is hydrogen atom, hydroxyl group, hydroxymethyl group or acetoxymethyl group; R4 is C5-C60 hydrocarbon group; and R5 is hydrogen atom or hydrocarbon group, containing in total 1-30 carbon atoms; (D) (D) 0.00012-10 wt % of at least one compound, selected from group, consisting of non-ionic surface-active substance, which has polyoxyethylene group and HLB 10 or higher, ionic surface-active substance and sphingosine salt; (E) 0.003-15 wt % of at least one compound, selected from group, consisting of sugar alcohol, selected from group, consisting of erythritol, threitol, xylitol and mannitol, disaccharide and trisaccaride, and (F) water.

EFFECT: emulsion composition preserves water in skin for long time.

13 cl, 1 dwg, 18 tbl, 64 ex

FIELD: chemistry.

SUBSTANCE: present invention refers to developing brewing products. According to the invention, a method for preparing an extract of polyphenols as a result of brewage involves the stages: contacting partially purified beer with resin, which adsorbs polyphenols; desorbing polyphenols adsorbed on the resin contacting with partially purified beer; adsorbing polyphenols on the second resin different from the first one; the above second resin is hydrophobic and non-ionic; and desorbing polyphenols adsorbed on the second resin with using an organic solvent; implementing the method is ethylacetate-free. The invention also refers to the method for preparing the extract of polyphenols as a result of brewage that involves the following stages: contacting partially purified beer with hydrophobic and non-ionic resin, which adsorbs polyphenols; and desorbing polyphenols adsorbed on the resin used at the previous stage of contacting with using the organic solvent; a desorption product contains at least 0.85 g of polyphenols per one gram of a dry matter. The invention also refers to the extract of polyphenols prepared by the above method and containing catechin, epicatechin, thyrozol and ferulic acid. The invention also refers to a cosmetic product, a functional food product, a food additive, which contain the above extract of polyphenols in an effective amount. Also the invention provides using the above cosmetic product for skin moistening and/or ageing prevention or delay, using the extract of polyphenols for producing an antioxidant composition.

EFFECT: invention provides preparing the extract of ethylacetate-free and high-purity polyphenols.

19 cl, 23 dwg, 22 tbl, 6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to an oral care composition, methods for preparing and using it. The presented composition containing a pre-mix containing arginine in the free form or in the form of a salt, a soluble carbonate salt and arginine bicarbonate formed in situ when mixing arginine in the free form or in the form of a salt with the soluble carbonate salt. The method for preparing the composition involves preparing the pre-mix by mixing arginine in the free form or in the form of the salt and soluble carbonate salt. What is also presented is an oral care procedure involving coating the patient's oral cavity with an effective amount of the above composition.

EFFECT: using the group of inventions provides positive effects achieved by using the oral care composition containing arginine bicarbonate in a combination with a simplified process of preparation of this composition.

15 cl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of pharmaceutics and represents a composition for oral cavity care in the form of dental varnish, containing bioactive glass and fluoride, where the said fluoride is present in the composition in an amount of up to 5% by weight. An increased ionic release is observed for the dental varnish containing bioactive glass and fluoride.

EFFECT: invention provides the creation of compositions, containing bioactive glass, for which in case of applying fluoride in lower concentrations (lower than 900 mln-1) its efficiency is the same as for higher concentrations (900 - 1450 mln-1).

3 cl, 2 ex, 6 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a compound with a woody note having structural formula I. In formula , the ring with 6 carbon atoms is saturated or has a double bond between carbon atoms C1 and C2 or between carbon atoms C1 and C6, R is selected from a C2-C5 alkyl or C2-C5 alkenyl group.

EFFECT: invention also relates to a fragrant composition containing said compound.

13 cl, 16 ex

FIELD: medicine.

SUBSTANCE: combined phyto- and physiotherapy is conducted. The phytotherapy involves administering Prolit Super 2 capsules two times a day (at 8 and 14 o'clock) for one month; the physiotherapy provides rectal electrical stimulation by means of AndroGyn for 8 minutes a day, 15 procedures in the therapeutic course.

EFFECT: invention enables improving the sexual function and prostatic microcirculation, and can be used in ambulance situation.

1 dwg, 1 ex

FIELD: veterinary science.

SUBSTANCE: method includes the complex application of systemic antimycotic agents, surface antifungal agents, additionally the preparation Forvet is injected in a dose of 0.2 ml per 1 kg of mass subcutaneously, for 7 days.

EFFECT: increased efficiency of treatment, no side effects and reduced remission time.

2 tbl

FIELD: chemistry.

SUBSTANCE: method includes treating crushed Echinacea purpurea (L.) Moench roots and rhizome with steam, extraction with ethyl alcohol, then steeping, stirring, steeping, draining a portion of the extract which is equal to the amount of the loaded Echinacea purpurea (L.) Moench roots and rhizome, after draining a portion of the extract, adding ethyl alcohol to the treated material, draining the whole extract; extracting crushed Echinacea purpurea (L.) Moench herbs with ethyl alcohol, steeping, then stirring, steeping, draining a portion of the extract which is equal to the amount of the loaded Echinacea purpurea (L.) Moench herbs, after draining a portion of the extract, adding ethyl alcohol to the treated herbs, draining the whole extract; all obtained extracts are mixed, cooled and filtered under certain conditions. An Echinacea purpurea (L.) Moench tincture. Use of the method to obtain an Echinacea purpurea (L.) Moench tincture.

EFFECT: method preserves the biological activity of components of the tincture and medicinal properties.

3 cl

FIELD: medicine.

SUBSTANCE: burn-treating composition for local application based on Vaseline lanolin, or carbopol, or hydrogel; as an active substance, the composition contains 5% dry extract of the herbal raw material big-flowered self and self-heal containing 60% rosmarinic acid.

EFFECT: above composition is effective for treating burns; it is non-toxic.

7 tbl, 10 ex, 12 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to synthesis of N-mono fluoroalkyl tropanes with application of fluoroalkyliodides, as well as to application of such method for obtaining non-radioactive tropane intermediate compound of formula and its further conversion into 123I-labelled radiopharmaceutical substance DaTSCAN (123I-ioflupane). Method consists in alkylation in presence of base of formula compound with alkylating agent of formula F-(CH2)mX, where m equals 2, 3 or 4, X represents I. .

EFFECT: obtaining non-radioactive tropane intermediate compound of formula and its further conversion into 123I-labelled radiopharmaceutical substance DaTSCAN (123I-ioflupane).

10 cl, 1 ex

FIELD: chemistry.

SUBSTANCE: composition of preparation for teeth cleaning contains effective quantity of arginine in free form or in form of salt; abrasive substance, containing (i) natural sodium carbonate (NSC) with the average size of particles 3-7 mcm and moisture absorption 12-25 g/100 g and (ii) precipitated calcium carbonate (PCC) with the average particle size 1-5 mcm and water absorption higher than 25 g/100 g. Ratio of natural calcium carbonate to precipitated calcium carbonate constitutes from 1:2 to 1:3. Composition has pellicle cleaning ratio (PCR), at least, 70 and value of abrasivity of isotope-labelled dentin (RDA) lower than 140. Method of oral cavity care includes application of effective quantity of said composition in oral cavity of individual requiring it.

EFFECT: effective teeth cleaning and strengthening without injuring abrasive action, which makes it possible to apply it, in particular, for individuals with increased teeth sensitivity.

13 cl, 2 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: composition contains a) surface-active substances, including a salt of C10-16 alcohol ethoxylate sulphate, a betaine surface-active substance and alkylpolyglicoside, and b) a fatty C12-18 acid, constituting at least 15% of the total composition weight.

EFFECT: composition, possessing an increased viscosity and capable of producing a stable foam, is created.

10 cl, 1 tbl, 4 ex, 2 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for producing a preparation applicable for oral tissue regeneration. A method for producing a multi-component melatonine-containing preparation for oral tissue regeneration, involving incubating eggs, cooling them, performing homogenisation and ultramicrofiltration; the incubation procedure is performed for 5-6 days; the ultramicrofiltration procedure is added with 0.1% sodium benzoate; the prepared substance of embryo-egg mass is added with a second substance containing medical gelatine, sage and St. John's wort tea, melatonine, eucalyptus oil, glycerol and prepared according to certain procedure that is followed by mixing in a homogeniser; the produced mass is bottled, placed in a thermostat, cooled until film hardened; the films are cut in strips 1 cm wide and packed into plastic package. The multi-component melatonine-containing preparation for oral tissue regeneration.

EFFECT: preparation prepared by the method described above is effective for oral tissue regeneration.

3 cl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for producing antioxidant microcapsules: vitamin A, C, E, Q10, eleuterococcus, green tea extract or ginseng extract. A method for producing antioxidant microcapsules: vitamin A, C, E, Q10, eleuterococcus, green tea extract or ginseng extract consists in using carrageenan as a microcapsule coating with dissolving a certain amount of vitamin A, C, E, Q10, eleuterococcus, green tea extract or ginseng extract in dimethylsulphoxide and dispersing the produced mixture into the carrageenan suspension in butanol containing carrageenan in the presence of E472c, agitating in certain circumstances; adding benzene and water, filtering the produced suspension and drying at room temperature.

EFFECT: method provides simplifying and accelerating the microencapsulation process, reducing the process loss, higher weight yield.

7 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, namely to an oral care composition and to a method for increasing the solubility of an active ingredient recovered from magnolia extract - tetrahydrohonokiol. The oral care composition contains an active ingredient recovered from the magnolia extract - tetrahydrohonokiol, propylene glycol and an orally acceptable carrier, in a certain amount.

EFFECT: content of the certain amount of propylene glycol in the oral care composition increases the solubility of tetrahydrohonokiol that leads to improving the effectiveness of its delivery and bioavailability.

3 cl, 8 tbl, 8 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

Up!