Method of increasing biological properties of antiseptic-stimulator of dorogov asd-2f

FIELD: biotechnology.

SUBSTANCE: increase in biocidal and immunobiological action due to the use of distilled water ionised with silver ions and adding into the composition of succinic, ascorbic, citric acid and aethonium.

EFFECT: increase in biocidal immunobiological properties of the antiseptic-stimulant of Dorogov ASD-2F.

6 ex, 1 tbl

 

The invention relates to biotechnology.

Known methods of increasing the effectiveness of ASD-2F with succinic and ascorbic acids, vitamins A and E (Isidima), metallocenter, formaldehyde, levamisole (Reference "Vidal vet", 2013, 32-33, patent RF №2303979 "Amber biostimulant, publ. 10.08.2007 G., patent RF №2351323 "Method of producing integrated product", publ. 10.04.2008; A. A. Iglewski, V. N. Skhirat "Modified levamisol - effective anthelmintic drug, veterinary science, No. 8, 2010, pp. 48-51; A. A. iglewski, T. I. Mikhaleva, O. N. Mikhailov "Immunometabolic drug activity on the basis of succinic acid and levamisole". Journal of the Kursk state agricultural Academy, No. 1, 2013, p. 64; A. A. Iglesia, G. F. Ryzhov, O. M. Shvets, "Development of a new generation immunometabolic drugs and the effectiveness of their use in veterinary medicine with the use of formaldehyde and trace elements." Journal of the Kursk state agricultural Academy, No. 5, 2010, pp. 70-71).

The disadvantage of these modifications with formaldehyde, levamisole is what is known by the decision who formaldehyde as carcinogenic drug with insufficient detoxifying effect - not recommended in the manufacture of vaccines, toxoids (Biologicals, M., 2001, No. 1, pp. 22-23).

The above disadvantages have caused the need to increase the biocidal and immunobiological properties of the ASD-2F and its modifications.

taken as a prototype method for producing a modified ASD-2F titled "Acidific", which contains the ASD-2F, succinic acid and vitamins A and E (Reference "Vidal vet", 2013, 32-33).

The disadvantage of this method are the insolubility of vitamins A and E in aqueous solutions and no biocidal effect on viruses and fungi.

An object of the invention is to increase the biocidal immunobiological properties of an antiseptic-stimulator Dorogova ASD-2F.

The technical result is to increase the biocidal and immunobiological action through the use of ionized silver ions with distilled water and making the composition of succinic, ascorbic, citric acids and etoniya.

The technical result is achieved by introducing 100 ml of a solution of ASD-2F 200 mg amber, 100 mg ascorbic, 100 mg of citric acid and etoniya 100 mg with subsequent activation of 1 mg of colloidal silver ions.

The results are presented the following examples.

Example 1.The study of shelf life.

The solutions of the modified antiseptic-stimulator Dorogova ASD-2F retain their original properties and appearance within 2 years (observation period).

Example 2.The definition of harmlessness of the drug.

Daily subcutaneous and intramuscular injection for 5 days 40 calves for 5.0 ml and 60 piglets 3.0 ml did not cause animals to increase the temperature of � necrotic lesions areas of the body at the injection site.

Example 3. The study of the biocidal properties of the drug.

The study of the biocidal properties were carried out in respect of the suspension 10 thousand/ml Staphylococcus, Salmonella, E. coli, fungi by mixing the modified ASD 2F in the ratio 1:1, 1:2 and 1:3, exposure of 60 minutes with subsequent seeding on nutrient medium.

The results are presented in the table.

From the data presented in the table, it follows that the bactericidal and fungicidal action ASD 2F and Acidific manifests itself in a dilution of 1:1 and the modified ASD-2F silver ions in a dilution of 1:1, 1:2 and 1:3, i.e. 2-3 times more concentrated than the original drugs.

Example 4. A method for the treatment of cows, patients with purulent-catarrhal mastitis.

The studies have used 68 cows sick with mastitis, which intracisternal were injected daily with 3-4 ml for 4-5 days with a syringe. In all animals of the treated residual processes mastitis is not installed.

Example 5. A method for the treatment of piglets, patients with dyspepsia.

Pigs (37 goals) - 1,5-2,0 months of age with pronounced diarrhea twice a day for 3-5 days gave feed 4-5 ml of the modified ASD-2F. All the 37 piglets after treatment returned to normal digestive processes. The diarrhea stopped, the side effects are not established.

Example 6. Treatment of dogs with lesions dermatitis the back and pelvic limbs.

In the experiment, 37 dogs 1-1,5 years of age of different breeds. To the affected areas of skin twice a day applied gauze soaked modified ASD-2F, and was subcutaneously injected once a day for 4-5 ml for 5-6 days. All the 37 dogs in 7-9 days stopped the lesions and scratching of the skin while normalizing skin and wool on the affected skin.

A method of improving the biocidal action against bacteria, viruses, pathogenic fungi antiseptic-stimulator Dorogova ASD-2F, characterized by introducing 100 ml of the drug solution 200 mg amber, 100 mg ascorbic, 100 mg of citric acid and etoniya 100 mg with subsequent activation of 1 mg of colloidal silver ions.



 

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