Method for surgical management of chronic periodontitis

FIELD: medicine.

SUBSTANCE: method involves professional oral hygiene is carried out consisting in ultrasonic removal of supra- and subgingival dental deposits and polishing of supragingival teeth. Bite splinting and recovery of dentition integrity may be required. After dissecting a mucoperiosteal flap according to the known technique, an incision area is sanitated by means of a photodynamic therapy (PDT). The PDT is conducted with the use of a diode laser at wave length 660±5 nm and emitting power 0.5-1.0 Wt. The photosensitiser "Photoditasin" in the form of 0.5% gel is introduced by means of a cannula into dental gaps, under the dissected segments of the flap and onto the mucosal tissue for 5 minutes. The photosensitiser is washed out, and the gingival pockets are repeatedly exposed to laser light for 2-3 min in the same environment. Sterile osteoplastic material is introduced into bone defects, and the flap is sutured together.

EFFECT: effective cleansing of the surgical area, eliminating the periodontal inflammation, stimulating tissue osteogenesis and regeneration, stabilising the processes of bone tissue absorption of alveolar interdental septa and preserving the tissues.

2 cl, 1 ex

 

The invention relates to medicine, namely to dentistry, and can be used in periodontal surgery in the treatment of chronic periodontitis of moderate and severe degrees.

Periodontitis - inflammation of the tissues surrounding the tooth, with the involvement of bone tissue, which is treatable pathology, but at the same time, requires a multidisciplinary integrated approach to treatment.

In recent years, periodontal disease rightly attract attention, because after 35 years, they are the most frequent loss of teeth. In recent years, accumulated a lot of evidence that because of parodontopathy can increase the risk of systemic diseases. This applies, for example, coronary heart disease, myocardial infarction, stroke, arteriosclerosis, risk of preterm birth, the birth of children with hypertrophy and other serious diseases.

An important task in the treatment are the most likely exception of the pathological factors; elimination of local irritating factors in the oral cavity; elimination of inflammation of periodontal tissues; suspension dystrophic process; restoration of disturbed functions of the periodontal tissues; stimulation of the regeneration process.

It is known that periodontitis is a complex disease, the pathogenesis of which one of the main roles played by bacterial invasion. Why�WMD one of the directions in the treatment of periodontitis is the elimination of pathogenic bacterial flora. Nevertheless, broad and unreasonable and uncontrolled use of antibiotics leads to the formation of strains of microbes that are resistant to antibiotics and other classes of antimicrobials (Tsarev V. N. etc. "the Etiology and current approaches to improving tactics of antibacterial therapy of patients with chronic generalized periodontitis (Dentist, No. 7, 2008, pp. 48, 49).

In dental practice, widely used methods of treatment using laser light (Prokhonchukov A. A. Zhizhina N. And. Lasers in dentistry. M., 1986, pp. 93-101). A wide spectrum of therapeutic effects of laser light has an impact on many of the leading pathogenetic links of chains of various diseases and results in a high therapeutic effect. For more effective treatment of periodontal disease and the mucous membranes of the oral cavity it is necessary to choose illumination modes affected by the pathological processes of tissue to provide stimulation of regenerative processes in these tissues.

The experience of domestic and foreign scientists shows that high-intensity and low-intensity laser radiation, successfully implemented in periodontal surgery to eliminate the inflammation of periodontal tissues, gives the opportunity to implement the principle of pathogenetic therapy. In recent� time there is a need to extend the use of high-intensity lasers for surgery on the periodontal tissues (A. A. Kunin, F. Burger, L. L. Hitrin, S. N. Pankova S. V. Erina, Voronezh, 1999).

A method of treating periodontitis (Pat. Of the Russian Federation No. 2160134), including gingivectomy and curettage, treatment in 2 stages: first, a high-energy laser are gingivectomy, decapitalization and closed curettage, and then low-energy laser therapeutic treatment of a scanning method. The high-energy laser has a capacity of 6-8 W and low energy - 2-3 watts. The exposure time of the tissue by the laser beam is 120-140 C. the Disadvantage of this method: a multistage process and a long period of time, cause undesirable thermal effects, the impossibility of complete removal of bacteria in hard to reach places, a closed curettage no access to pathological tissues and bacterial agents that are deeper periodontal pocket, there is no way to adequately assess the degree of damage of periodontal tissues and in accordance with this treatment. Furthermore, the method is suitable for the treatment of periodontitis mild severity.

A method of treating chronic periodontitis (Pat. Of the Russian Federation No. 2460491), including the removal of dental plaque, polishing teeth, closed curettage of periodontal pockets and photodynamic therapy using 1% gel "Fotoditazin", which is applied on inflamed surface �letisti of the oral mucosa and periodontal pockets for 8-10 min, then the gel is washed away and carried out the irradiation of periodontal pockets laser radiation in a continuous mode, wherein the scaling is carried out by ultrasonic supragingival surface treatment of the teeth, additionally, conduct the subgingival treatment of teeth roots, and debridement of periodontal pockets by low-frequency ultrasound apparatus of the "Vector" and acupuncture needles into active points within 15-20 min, and the first session of a course of acupuncture performed on the day after the photodynamic therapy, and the subgingival treatment of teeth roots and debridement of periodontal pockets by low-frequency ultrasound apparatus of the "Vector" is carried out twice - the first time - before the curettage of periodontal pockets, and the second - after the course of acupuncture. Photodynamic therapy using a diode laser "Prometheus" using the following settings laser: wavelength 660±5 nm, the radiation power of 0.2 W, while the periodontal pocket irradiation is carried out for 1-2 min, the total procedure time to 20-30 min. the Disadvantages of the method: a closed curettage no access to pathological tissues and bacterial agents that are deeper periodontal pocket, there is no way to adequately assess the degree of damage of periodontal tissues and in accordance with this conduct �of Directors. Furthermore, the method is suitable for the treatment of periodontitis mild severity.

Photodynamic therapy (PDT) is well known and has been used to combat numerous diseases generally associated with excessive proliferation of tissue. PDT has also been used as an antimicrobial treatment. However, there are two main problems associated with antimicrobial PDT. The first problem is the difficulty of detection photoactive substances that can be used effectively against gram-positive and gram-negative bacteria. Gram-negative bacteria pose a much more difficult obstacle, primarily due to double-layer the structure of their outer membrane.

On the basis of scientific and practical experience of dentists has accumulated a large amount of different methods of treatment of periodontal disease. However, dissatisfaction with the quality, timing and long-term results of treatment leads to search for new methods and to improve them. Treatment of periodontal disease is not currently possible without surgical methods, however, must be conducted in nevospalennah the mucous membrane, which creates the possibility of long-term positive effect of therapy.

The most radical, but at the same time, effective treatment of moderate and severe periodontitis grade� is a patchwork operation, during which deletes all the inflammatory tissue of the interdental spaces, ground and polished the surface of the roots, processed and modeled Muco-periosteal flap. But treatment does not always give a positive result. Quite often there are complications in the form of recurrence in short-and long-term follow-up, especially with the resorption of bone tissue to the tips of the interdental septa, leading to atrophy of the gingival margin and the exposure of the necks of the teeth.

Thus, the known method of surgical treatment of chronic generalized periodontitis, including: 1 - preoperative oral hygiene: removal of above - and subgingival dental plaque, dental caries treatment and its deposits, elimination of traumatic factors and traumatic occlusion, splinting of mobile teeth, removal of inflammation in the soft tissues; 2 - conduct basic patchwork gingivoplasty technique Ashinskogo-Widmann-Neumann modified by V. A. Kiselev (1969), involving a local anaesthetic holding on the limits of the area being operated two vertical cuts on the amount of bone pockets and horizontal cuts from the buccal and lingual sides of the periodontal connection with dissection of the interdental papillae, exfoliation of the mucoperiosteal flap, removal of remaining subgingival subdirectory and granulation tissue from bony pockets alveolar bone with subsequent filling of bone flour from dried tissue decapitalization the inner surface of the marginal edge of the gums, antiseptic treatment and the placement of the grafts in place, their closure with sutures in each interdental gap and closing the operating surface protective gingival dressing. The disadvantages of this method are: 1) lack of guaranteed full reparation periodontal structures; 2) uncontrolled or significant postoperative difference in the regenerative potential of periodontal tissues - bones and soft tissue that prevents the formation of reliable new subepithelial connection, does not exclude the possibility of proliferation and migration of long connective epithelium and leads to a high probability of development of complications; 3) reduction of primary cosmetic effect; 4) exposure of the necks of the teeth; 5) hyperesthesia bare cement; 6) the possibility of development of caries of cement, etc. in spite of these shortcomings, the discussed method is more effective than prior methods of surgical treatment and conservative therapeutic measures. In this regard, he currently is the base of and is recommended for wide clinical use [Yu Bernadsky, 1999].

The use of laser technology together with the surgical treatment appears to be most�more promising.

Thus, the known methods of treatment of periodontitis, including the effects of laser light in combination with a patchwork operation (Pat. Of the Russian Federation No. 2241507, 2101047). In the known methods is solved a number of major challenges: 1) elimination of inflammation of the gingival margin; 2) the opening and emptying of gingival abscesses; 3) removal of sediments; 4) elimination of inflammation after tooling tissues of the gingival margin; 5) stimulation of healing of the gingival margin. The disadvantages of the proposed methods is that they do not allow to intensify osteoregeneration with prevention of symptoms of neuropathy. In addition, it is necessary to use different types of laser machines, which is not always possible in a clinical setting, is not taken into account the need for a focused regenerative therapies, that is, the additional use of drugs, accelerating the regeneration processes in periodontal tissues.

The known method of treatment of periodontitis, in which when carrying out patchwork surgery bone pockets fill various drugs and osteoplastic materials (us Pat. Of the Russian Federation No. 2292884, No. 2242253).

It is known to use different materials in the surgical treatment of periodontitis, for example: drugs are Bio-Oss, Bio-Gide company Geistich (W. "New in dentistry", No. 8, 2001, pp. 72-77); a suspension of cell line M-22 diploid fibroblasts of the skin and muscles emb�ion man cultured in the medium NEEDLE with the addition of blood serum of cattle (W. "Cytology", No. 9, vol. 43, 2001, pp. 853-854); polytetrafluoroethylene membrane (W. "New in dentistry", No. 6, 2001, pp. 47-57); drug kollapen ("Application biocomposting materials in maxillofacial surgery and dentistry: materials of the 1st all-Russian scientific conference. - M., 1997, pp. 39-40). The disadvantages of the known methods of surgical treatment of periodontitis with the use of the proposed substitute materials are: the complexity of manufacture of the residual material (such as application of glass-ceramics, soaked in blood plasma); traumatic intervention on the donor site (for example, when using autologous bone); the risk of infection and development of allergic reactions (for example, when using demineralized bone matrix and breakast).

Known method of surgical treatment of severe periodontitis with the use of osteoplastic material Emdogain for healing of the mucosa during surgery on the periodontium (Pat. THE RUSSIAN FEDERATION THE RUSSIAN FEDERATION NO. 2343858).

Emdogain - medication biological basis consisting of hydrophobic proteins of the enamel matrix (amelogenin derived from developing embryos embryos of teeth of pigs), which restores the fabric required to create a functional be�ing the teeth, affected by periodontitis moderate or severe.

Emdogain is intended for use in periodontal surgery as an option, contributing to a favorable outcome in the treatment of intraosseous defects formed after moderate or severe periodontitis and periodontitis. After surgery Emdogain dissolves naturally in the healing of the wound, leaving a layer of enamel matrix proteins on the root surface. This layer leads to the formation producing the cement cells from the surrounding tissues.

Emdogain consists of two components - proteins of the enamel matrix (Emdogain) and particles of synthetic alloplastic bone graft (PerioGlas). Proteins of the enamel matrix are amelogenins derived from developing embryos of teeth of pigs, promotes tissue repair, required to create a functional attachment of the teeth by creating a layer of enamel matrix proteins on the root surface, promoting the formation of cementproduction cells.

The closest to the claimed technical solution is a method of surgical treatment of severe periodontitis (Pat. Of the Russian Federation No. 2343858), which includes exfoliation of the mucoperiosteal flap, debridement of the operated area by removing bone pockets subgingival dental plaque, granulation � necrotic tissue, the roots of teeth polishing preparation, introduction to sterile bone defects osteoplastic material Emdogain, stitching flap. The disadvantage of this method: the impossibility of complete cleaning of the surgical field from numerous microorganisms and abnormal tissue, invisible to the eye dentist.

The objective of the proposed technical solution is to provide a method that improves the efficiency of treatment of chronic periodontitis with tooth mobility II and III, with the use of patchwork operations and modern methods of antiseptic treatment and drugs, contributing to cementogenesis.

In particular, the use of photodynamic therapy during the quilting operation will allow to fully clear the operative field from numerous microorganisms and pathological tissue invisible to the eye doctor, the dentist, and the use of ustestimonials plastic material in a gel base to avoid injury to the donor site of the bone and stimulate osteogenesis. Such an integrated approach to the treatment of periodontal diseases moderate and severe using surgical treatment with photodynamic laser therapy and osteoinductive gels contributes to the preservation of the teeth and increase the effectiveness of treatment. Thus, reach the most important�enny results by influencing the drive links of the pathological factors abstemious periodontitis: 1) elimination of inflammation of periodontal tissues; 2) stimulation of regeneration of periodontal tissues; 3) stabilization of the processes of resorption (resorption) of bone tissue to the tips of the interdental septa of the alveoli.

The problem is solved by the use of the method of surgical treatment of severe periodontitis, including pre-professional oral hygiene, which is the removal of supra - and subgingival dental plaque by ultrasound, supragingival polishing of the teeth, if necessary, the holding of splinting and restore the integrity of the dentition, subsequent exfoliation of the mucoperiosteal flap, debridement of the operated area using photodynamic therapy, introduction to sterile bone defects osteoplastic material, the stitching of the flap. After exfoliation of the mucoperiosteal flap by well-known methods, conducting photodynamic therapy using a diode laser at a wavelength of 660±5 nm and the radiation power of 0.5-1.0 W by insertion through the cannula of the photosensitizer "Fotoditazin" in the form of 0.5% of the gel into interdental spaces, under the delaminated areas of the flap and the lining fabric for 5 minutes, then photosensitizer wash and re-irradiation of periodontal pockets laser radiation within 2-3 min under the same conditions. As sterile osteoplastic material used�form osteoplastic material Emdogain.

The method is as follows.

Before the procedure, the treatment of chronic periodontitis of moderate or severe extent necessary to carry out sanitation of the oral cavity. For three or four days before the planned operation is carried out to a professional hygiene with removal of supra - and subgingival dental plaque using ultrasonic scaler "P5 Booster" "Satelec" (France), supragingival polishing of the teeth using brushes, gum, and toothpaste Detartrine" Septodont) (France). In the absence of dentition defects included or single on the defects it is necessary to conduct splinting with Ribbond material or Fiber Splint or analogues, and restore the integrity of the dentition with the use of artificial teeth or a composite material. When preparing the patient for further prosthetics, splinting of teeth can be carried out using temporary crowns.

Immediately before surgery it is necessary to conduct psychological preparation of the patient, premedication, then antiseptic treatment of the surgical field. Anesthesia is performed with the use of infiltration or block anesthesia. An incision is made along the edge of the alveolar ridge using traditional techniques with a scalpel. Exfoliation of the mucoperiosteal gloss�and carried out with vestibular and oral sides using standard surgical instruments. This is followed by a session of photodynamic therapy. This uses photosensitizing drugs, operating on the principle of penetrators on a gel base, for example gel-penetrator "Fotoditazin" of 0.5%. Using a cannula inserted into interdental spaces and under the delaminated portions of the flap, as well as on the mucous membranes, the affected pathological granulation tissue at 5 min, and then, without washing the drug, is the exposure of the surface of the mucosa and the roots of the teeth by laser radiation with a wavelength of 660±5 nm with a capacity of 0.5-1 W by the nozzle on the light, reproducing the circular radiation to a diameter of 600 μm for 5 min. After that the drug is washed with saline solution and re-processed with laser radiation with the same parameters within 2-3 min to activate the photosensitizer, accumulated in the granulation tissue and microorganisms. Later in bony pockets you enter osteoplasties material with osteoinductive properties on a gel base, for example, the drug Emdogain (Switzerland) or equivalent, modified flap sewn.

During the procedure you used a diode laser device "LAMY" for photodynamic therapy with a wavelength of 660±5 nm. You can use any laser device with the same parameters, with the energy of the light heels�and in the affected area ≥95 kJ/cm 2. The drug gel penetrator "Fotoditazin" 0.5% of the photosensitizer on the basis of chlorine E6, the main substance of which is N-dimethylglycine salt of chlorin E6 that comes in a disposable syringe in sterile packaging. As such, the introduction of the drug in the periodontal tissues is very comfortable using a disposable sterile injector. As a result of mechanical action of a surgical instrument cleaning inevitably formed the smear layer and bacterial biological film, which can have a negative impact on the regeneration of periodontal tissues and interfere with it. Gel-penetrator "Fotoditazin" has the ability to accumulate in pathogenic microorganisms and abnormal cells of the periodontium. When exposed to irradiation of monochromatic laser light with a wavelength of 660±5 nm occurs photochemical reaction, to produce singlet oxygen, which triggers a chain of oxidative processes, leading to destruction of pathogenic microorganisms, forming a biological film on the surface of the roots, and the destruction of pathological tissues in the periodontium. In addition, under the action of the drug "Fotoditazin and laser radiation is cleansed dentinal matrix and the exposed collagen fibers on the root surface. Used photodynamic�ski gel penetrator "Fotoditazin" penetrates into hard-to-reach abnormal areas of the periodontium, which cannot be seen with the eye and hold their capital using standard surgical techniques and standard antimicrobial therapy. Fotoditazin designed to enhance the penetrating influence of a source of light energy used in therapy, including photodynamic therapy for different types of exposure to light. Maximum efficiency is achieved when the gel light wave length 660±5 nm.

The method of PDT is to destroy cells of pathogenic microorganisms and pathologically changed tissues of the periodontium after their interaction with a photosensitizer "Fotoditazin" or equivalent, and subsequent irradiation of monochromatic medical laser treated area periodontal. Applied to the affected area with the gel-penetrator "Fotoditazin" accumulates in pathogenic microorganisms and abnormal cells of the periodontium. Under the influence of laser irradiation photochemical reaction occurs, during which the allocated active (singlet oxygen), which triggers a cascade of oxidative processes, leading to the death of pathogens and the destruction of pathologically changed tissues of the periodontium. After photodynamic therapy with the drug "Fotoditazin" disappear symptoms of inflammation, healing is accelerated, increases local immunity�, the pain is reduced.

Surgical treatment of periodontitis severe and moderate the proposed combined method with the use of photodynamic therapy and osteoinductive drug improves therapeutic effect, eliminates the traumatic intervention on the donor site, extends the treatment of severe forms of periodontitis, which is especially important for the preservation of teeth with loss of supporting retention of periodontal tissues to a greater depth.

Thus achieve the most significant results by influencing the drive links of the pathological factors of chronic periodontitis: elimination of inflammation of periodontal tissues; stimulation of regeneration of periodontal tissues; the stabilization of the processes of resorption (resorption) of bone tissue to the tips of the interdental septa of the alveoli; no complications; no exacerbations and relapses; adaptation of periodontal tissues of the teeth to increased masticatory load when you use them as a reference for the prosthetic dental bridge or partial dentures.

The proposed method gives good economic benefit due to the following components of treatment: the use of this method contributes to the preservation of natural teeth, which undoubtedly leads to improved quality of life and, as reflective of�, proceeds from this economic effects: reducing the consumption of medicines and auxiliary materials (gingival bandages, mouthwash, etc.); reduction of terms of treatment; improving the productivity of doctors and nurses.

The proposed method is confirmed by the following clinical example of treatment of chronic periodontitis.

Example 1. Patient S., 44 years. Diagnosis: chronic periodontitis. Applied for the purpose of rehabilitation of the oral cavity and further prosthetics. Complaints: tooth Mobility, bleeding gums, exposing the roots of the teeth, increased sensitivity to temperature and chemical stimuli. Objective: the Mucosa hyperemic, edematous, there are supra - and subgingival dental plaque, hard and soft plaque, in many parts of the roots of the teeth exposed, partial absence of teeth. The depth of periodontal pockets 4-5 mm. orthopantomogram marked destruction of bone tissue of all teeth 5 mm before the root apex in some areas.

Treatment the patient began rehabilitation of the oral cavity, cavities have been treated and sealed, supra - and subgingival dental plaque removed using ultrasonic scaler "P5 Booster" "Satelec" (France). Since the patient is shown a prosthesis using fixed constructions, was �rovedine odontopediatria using the technique of preparation with supra ledge. Conducted mining teeth with temporary plastic crowns. Before the surgery, a temporary splint was removed. Under infiltration anesthesia spent the incision of the mucous membrane along the alveolar crest and trapezoidal cross sections with the vestibular and palatal sides, then lift the Muco-periosteal flap. Then underwent photodynamic therapy using laser "LAMY" with a wavelength of 660 nm and the drug "Fotoditazin". While photodynamic therapy was performed as follows: the drug "Fotoditazin" (gel of 0.5%) was applied under the delaminated flap on the surface of the teeth and the mucous for 5 min. Then, without washing the gel, carried out the irradiation of pathological tissues by laser radiation through optical fiber section 600 µm for 5 min, using the following settings laser: wavelength is 660 nm, the radiation power of 0.5-1.0 W, mode - continuous. Then the gel was washed with saline and underwent re-irradiation with the same settings for 3 min. Then under the flap introduced osteoinductive material on the basis of Emdogain gel (Switzerland), the flap was sutured using a suture material Vicryl". Teeth are fixed using the tire as a temporary plastic structures. Recommendations on oral hygiene for a period of rehabilitation in the future �donkey therapy.

The patient was observed after 1, 3, 6, 12, 24 months. In the coming period of observation the patient had no complaints. Complete healing at 1 month. The mucous membrane of gingival papillae without signs of congestion, normal pale pink color, dental plaque absent. Tooth mobility decreased significantly. After 6 months of routine inspection, in a satisfactory condition, missing tooth mobility, inflammation, depth of gingival sulcus is 0.5-1 mm. Held a permanent prosthesis using metalloceramic fixed constructions. After 24 months, no complaints, no visible signs of inflammation, the state of oral health is satisfactory, the mucous gingival papillae pale pink color, above - and subgingival dental plaque absent.

1. Method of surgical treatment of severe periodontitis, including pre-professional oral hygiene, which is the removal of supra - and subgingival dental plaque by ultrasound, supragingival polishing of the teeth, if necessary, the holding of splinting and restore the integrity of the dentition, subsequent exfoliation of the mucoperiosteal flap, debridement of the operated area with photodynamic therapy, the introduction into the bone defect sterile osteoplasties�wow material the stitching of the flap, characterized in that after separation of the Muco-periosteal flap by well-known methods carried photodynamic therapy using a diode laser at a wavelength of 660±5 nm and the radiation power of 0.5-1.0 W by insertion through the cannula of the photosensitizer "Fotoditazin" in the form of 0.5% of the gel into interdental spaces, under the delaminated areas of the flap and the lining fabric for 5 min, then photosensitizer wash and re-irradiation of periodontal pockets laser radiation within 2-3 min under the same conditions.

2. A method according to claim 1, characterized in that the sterile osteoplastic osteoplastic material used material Emdogain.



 

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EFFECT: described invention is successfully used for the above purposes.

17 cl, 11 ex, 7 tbl, 11 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, namely to an oral care composition and to a method for increasing the solubility of an active ingredient recovered from magnolia extract - tetrahydrohonokiol. The oral care composition contains an active ingredient recovered from the magnolia extract - tetrahydrohonokiol, propylene glycol and an orally acceptable carrier, in a certain amount.

EFFECT: content of the certain amount of propylene glycol in the oral care composition increases the solubility of tetrahydrohonokiol that leads to improving the effectiveness of its delivery and bioavailability.

3 cl, 8 tbl, 8 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for oral cavity care. Compositions include a multi-layered film and an orally acceptable carrier. The carrier contains the first flavouring agent, with the second flavour being contained in the present central layer of the multi-layered film, located between two external surface layers. The first and second flavouring agents can be similar or different. Each film layer can include a film-forming polymer, for instance, hydroxypropylmethylcellulose. The external layers can include a substance, modulating the release of the flavouring agent, for instance, polyvinylacetate or hydroxymethylcellulose. The carrier can be a means for teeth cleaning or a liquid for mouth rinsing.

EFFECT: obtaining the composition for oral cavity care.

22 cl, 3 dwg, 4 tbl, 11 ex

FIELD: medicine.

SUBSTANCE: vaseline-lanolin (2:1) based ointment 74.0 g is added with a 40% herbal alcoholate 25 ml of the following composition (in the mixture of a herbal raw material: alcohol base - 1:5), weight fractions: nodding catchfly herb - 3 weight fractions, pot marigold blossom - 1 weight fraction, spiraea herb - 1 weight fraction, with the ointment added with clove oil 1.0 ml. The prepared ointment is applied on inflamed periodontal and oral mucosal tissues for 20 minutes 2-3 times a day for 14 days; the patient is advised not to drink or eat for 1 hour.

EFFECT: method enables increasing clinical effectiveness by combining high antimicrobial, immunomodulatory, anti-allergic and keratoplastic activity and ease of use.

3 ex

FIELD: medicine.

SUBSTANCE: on completion of the antibacterial course, sodium hyaluronate in the form of a gel is single administered by means of a syringe with a needle of 2 cm long or more under an oral mucosa along a transitory fold into the points within projections of apexes of dental roots 1.4, 2.4, 3.6, 4.6 and into a point on the mid-line of projections of apexes of anterior roots of upper and lower jaw respectively. The needle is brought under the mucosa on the lower jaw by transecting the projections of an alveolar counterfort line. On the upper jaw - by transecting the projections of the upper counterfort line. While removing the needle from the mucosa, the syringe content is squeezed out. Sodium hyaluronate is administered into both jaws in an amount of 3.0 to 4.4 ml.

EFFECT: method enables increasing the jaw bone density within counterforts, as well as soft and bone tissues of periodontium.

4 tbl, 16 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to dentistry and concerns treating chronic generalised periodontitis. Implementing the above method is ensured by a complex preparation in the form of an ointment of the following composition: Vaselin - lanolin base (1:1) - 88.5 g, 70% ipecac infusion - 5.0 g, 70% scholar tree - 5.0 g, Ecdysterone - 0.02 g; eucalyptus oil - 1.0 g. The oil is applied as a therapeutic periodontal applicate on a gingival surface following application anaesthesia with 10% lidocaine, chairside oral hygiene, drug-induced treatment of the gingival margin with 1% Iodinolum and separation of salivary glands in the oral cavity, once a day for 2 hours for 4 weeks; the patients are recommended not to eat or drink for two hours. The preparation composition particularly provides capillary-reinforcing, anti-inflammatory, reparative and anaesthetic action.

EFFECT: method of treating is easy to use, physiologically-friendly, and provides the complete recovery.

2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) : or a salt thereof, wherein R1 and R5 are independently selected from H, OH and alkoxy; R2-R4 and R6-R8 are independently selected from H, OH, F, Cl, Br and I; R9 and R10 are C2-C8 alkenyl; under the condition that at least one of R1, R5 and R7 is OH or alkoxy; at least one of R2-R4, R6 and R8 is F, Cl, Br or I; and R2 and R6 are Cl. The invention also relates to an antibacterial composition and treatment methods.

EFFECT: improved properties.

18 cl, 7 ex, 10 tbl

FIELD: medicine.

SUBSTANCE: agent for treating inflammatory periodontal and oral mucosal diseases associated with Helicobacter infection contains silicone glycerohydrogel of Si(C3H7O3)4·6C3H8O3·24H2O and bismuthate tripotassium dicitrate of formula [HOC(CH2COO)2COO]2K3Bi in the following proportions, wt %: bismuthate tripotassium dicitrate 1.0-2.5; silicone glycerohydrogel - the rest up to 100. The method of treating inflammatory periodontal and oral mucosal diseases consists in a combination of systemic standard anti-Helicobacter therapy and a local effect of the above agent on the involved region. Particularly, treating periodontitis is ensured by applying the agent on the gingival surface and introducing it into the gingival pockets once a day for 10 min; the therapeutic course makes 5-6 days. The oral mucosal diseases are treated by applying the agent 0.1 mm thick with a glass spatula on the involved oral mucosa 2 times a day; the therapeutic course is 12 days.

EFFECT: formulation of the agent provides achieving the high therapeutic effect; the dosage form is easy to be applied locally.

4 cl, 2 dwg, 1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: method includes the preparation of a carious cavity, opening the tooth cavity, creation of an access to root canals, extension of their orifice. Removal of a decayed material from the root canals and their drug treatment are carried out. After that, performed are: wide opening of the apical tooth orifice, mechanical and drug removal of periapical pathological exudative formations in the focus of periapical inflammation through the root canal. Before filling the canal with a filling material the gel "Lamifaren" is introduced into the focus of periapical destruction. Such introduction is performed three times after a day under temporary stopping. The gel "Lamifaren" is introduced inside in a dose of 50 g 2 times per day for 30 days.

EFFECT: application of the invention accelerates bone tissue regeneration due to the active release of an active substance calcium alginate, provides stable remission due to local and systemic detoxifying effect.

2 ex

FIELD: medicine.

SUBSTANCE: treatment is two-staged; at the first stage, gingival pockets are rinsed with a stream of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth. If observing the exposed furcation of premolars and molars, the cannula is brought under the root furcation. Thereafter, the gingival pockets are similarly rinsed with an aqueous tincture of garden sage herb for 3-5 days, then with an aqueous tincture of camomile blossom for 3-5 days, an aqueous tincture of plantain leaves daily for the following 3-5 days; each rinsing procedure is followed by applications of cotton drains impregnated with the respective aqueous herbal tincture introduced by the cannula on gingival mucous membranes for 1 hour; that is combined with prescribing oral baths with the respective aqueous herbal tincture introduced by the cannula daily 5-7 times a day. The second stage involves instillations of Normoflorin-B or Bifidumbacterin in the cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; the gingival mucous membranes are laid with cotton drains with the above preparation for 2 hours daily for 5-10 days.

EFFECT: method enables providing the higher clinical effectiveness.

2 cl, 1 ex

FIELD: medicine.

SUBSTANCE: at the first stage, after removing supra- and sub-gingival dental calculus and granulations, cleaning the teeth professionally, rinsing gingival pockets by stream infusions of 1.5% hydrogen peroxide in a cannula delivered through the gingival pockets around the teeth, brought under root furcation if observing the exposed furcation of premolars and molars; the preparation "Calsept" is administered within the frontal teeth for 5-7 days daily into the gingival pockets bringing the cannula similarly around the teeth, whereas the preparation "Calsept-Iodo" is administered within the distal teeth; the dentist recommends that the patient does not eat for 2 hours thereafter. The second stage involves administering a preparation containing bifidus bacteria, e.g. Normoflorin-B or Bifidumbacterin by instillations in a cannula delivered through the gingival pockets around the teeth, brought under the furcation if observing the exposed furcation of premolars and molars; gingival mucous membranes are laid with cotton drains with the preparation for 2 hours daily for 5-10 days.

EFFECT: using the method provides increasing the therapeutic effect ensured by the antibacterial effect, odontotropic and anaesthetic action, bone tissue recovery, action of the therapeutic preparation in difficult-to-access anatomic formations.

2 cl, 1 ex

FIELD: veterinary medicine.

SUBSTANCE: in down-calving cows the entire mammary gland is irradiated with the contact method with scanning using laser beam with a wavelength of 0.63 microns. The low-intensity laser emitter power is 30 mW. The procedure is carried out for five minutes and is repeated five times with an interval of 48 hours.

EFFECT: method enables to increase the effectiveness of prevention of mastitis by increasing the overall and the local resistance of the cow organism prior to calving, increase in the activity of antioxidant defence of the organism, reduction of toxic load to its organism.

3 tbl

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