Antiseptic sorption material, method for making it and based wound healing dressing

FIELD: medicine.

SUBSTANCE: what is described is an antiseptic sorption material having the anti-inflammatory, wound-healing, absorbent, astringent and antiseptic action representing a microfiber matrix with a disperse adsorbent attached to its fibres and containing highly porous alumina hydrate particles and zinc oxide particles. A method for making the same and a based dressing are also described.

EFFECT: material is applicable for making wound dressings having additional functional properties and maintaining the absorbing properties of the material absorbing the wound discharge, inhibiting bacterial growth inside the dressing and preventing the wound re-infection.

15 cl, 4 dwg, 2 tbl, 3 ex

 

The invention relates to an absorbent non-woven materials containing dispersed sorbents, and can be used in medicine, particularly relates to the production of bandaging materials (medical wipes, bandages, etc.) intended for closing wounds.

Known wound healing following medical materials obtained by forming a dispersed sorbents in microfibrous matrix with the use of nanoscale particles on the basis of aluminum, obtained by the method of electric explosion of wire. As a method of making such particles in the particulate sorbent is used for the operation of their hydrolysis in the presence of fibers.

In the patent of Russian Federation №2397781 "non-Woven material medical purpose, has wound-healing, antibacterial and antiviral activity and dressings based on it," declared the application for a new medical purpose are known from the patent of Russian Federation №2317843 filter material.

Mentioned non-woven material for medical use contains no antimicrobial component that may lead to the reproduction of pathogenic micro-organisms present in the wound exudate, in the bulk material and to a secondary infection of the wound.

In the patent of Russian Federation №2394627 offered health structure, including, along with the nanofibers of aluminum oxide, in�which contain fibers, mixed with nanofibers of aluminum oxide, and particles, distributed in the nanofibers of aluminum oxide. Many of the particles located on the nanofibers of aluminum oxide, selected from the group consisting of ion exchange resins, catalyst, metal oxide. These particles selected from the group consisting of fine particles having an average size between about 10-44 microns, ultramatic particles having an average size between 0.1-10 μm, and nano-sized particles having a size less than 0.1 μm. These particles of metal oxide selected from the group consisting of colloidal silica, colloidal alumina, nanooxide zinc and nanooxide titanium.

The proposed structure of medical use is prepared by mixing a large number of individual components, followed by a wet molding the resulting mixture, and mentioned many of the particles previously deposited on these nanofibers of aluminum oxide, which greatly complicates the process of obtaining the structure of medical use.

In the patent of Russian Federation №2426557 "Sorption-bactericidal material, manufacturing method thereof, a method of filtering liquid or gaseous media, medical sorbent" declared material containing non-woven polymer fiber material attached to its highly porous fibers cha�the tics of hydrate of aluminum oxide, while inorganic antibacterial component adsorbed on highly porous particles of hydrate of aluminum oxide. The method of obtaining sorption-bactericidal material comprises treating the material with a solution of inorganic antibacterial component and processing of non-woven polymeric fiber material, the fibers of which are enshrined highly porous particles of hydrate of aluminum oxide, in a period of time not exceeding 24 hours.

Material handling solution inorganic antibacterial component is an optional stage, complicating the process of obtaining sorption-bactericidal material, only provides antimicrobial properties and gives the material a wound, absorbent properties.

The object of the invention is to develop a new antiseptic sorption material for the production of wound dressings with additional functional properties - healing, anti-inflammatory, absorbent, antibacterial, while maintaining the absorption properties of the material, providing the possibility of absorption of wound content (exudate), suppress bacterial growth within the dressing and to prevent secondary infection of the wound.

The problem is solved in that the proposed antiseptic sorption mate�ial, possessing anti-inflammatory, wound healing, absorbent, astringent and antiseptic action, which is mainly suitable for the production of dressings for treatment of wounds, as known, is a microfibrous matrix attached to fibers dispersed sorbent.

What is new is that a particulate sorbent it contains highly porous particles of hydrate of aluminum oxide particles and zinc oxide.

In addition, as the microfiber matrix polymer selected microfiber material obtained by molding from a solution or melt of polymer technology spunbond, meltblown or electrovanne cellulose acetate, polysulfone or other bioinert polymer having a fiber diameter of 0.1-10 microns, preferably 1-3 microns.

And highly porous particles of hydrate of aluminum oxide are mainly agglomerates formed by neoplastically of pseudoboehmite, and particles of zinc oxide, representing, primarily, the agglomerates of hexagonal plates of zinc oxide.

The highly porous agglomerates of particles of hydrate of aluminum oxide and agglomerates of particles of zinc oxide uniformly distributed on the fibers and to the extent the microfiber matrix.

In addition, agglomerates of nanoplastic of pseudoboehmite and agglomerates of hexagonal place�monk of zinc oxide have an extensive misopristol: the size of the mesopores is 4-10 nm, the volume of mesopores is 0,45-0,65 cm3/g, and specific surface area lying in the interval from 200 to 280 m2/g.

The number of particles of particulate sorbent material is from 15 to 45%.

In addition, the weight ratio of highly porous particles of hydrate of aluminum oxide and particles of zinc oxide is from 5:95 to 95:5.

In this specific offer antiseptic surface of the sorption material is in the range of values from 70 to 100 m2/g.

In addition, to using it as material for medical use said material further comprises at least one layer of atraumatic material intended for placement on the wound surface.

In addition, said material further comprises at least one layer of protective material, located either on one or on both sides.

Another object of the invention is a bandage for treatment of wounds, has anti-inflammatory, wound healing, absorbent, astringent and antiseptic effect, containing at least one first layer mentioned material and at least one second layer of atraumatic material.

Furthermore, the bandage further comprises at least one layer of protective material arranged on either one, or on both sides.

Furthermore, the bandage further comprises elements for fixing it to the body of the person.

Another object of the invention is a method of producing antiseptic sorption material, which is carried out:

- select the microfiber matrix, mainly obtained by the method of electrotorture cellulose acetate, polysulfone or other bioinert polymer having a fiber diameter in the range from 0.1 to 10 μm, preferably, from 0.5 μm to 3.5 μm;

- modification mentioned microfibrous matrix atmospheric plasma to improve its adhesion properties (increasing roughness, wettability);

- the wicking microfiber matrix with a suspension containing a precursor multicomponent nanoscale particles comprising phases of aluminum and zinc;

- implementation of heat treatment microfibrous matrix impregnated with the aforementioned slurry to form a dispersion of the sorbent on the fibers and to the extent the microfiber matrix.

Preferably, for the modification of the matrix of microfibers used the processing of low-temperature atmospheric plasma discharge with runaway electrons (ADRE-plasma).

In addition, as a precursor to use of multicomponent nanosized particles of composition,�redesenho formula Al/Zn or Al/AlN/Zn.

The size of the aforementioned particles is in the range from 50 nm to 150 nm, preferably from 80 nm to 120 nm, and specific surface of the above-mentioned particles is from 7 to 22 m2/g, preferably from 10 to 18 m2/g.

It is preferable that the nanosized particles obtained by the method of electrical explosion of wire.

In addition, heat treatment is carried out initially at the linear heating from 20 to 90°C at a heating rate of 5 to 10 ° C/min, and then at a constant temperature lying in the range of 50 to 90°C, preferably from 60 to 80°C, and humidity from 60 to 95%.

When applying suspensions of nanosized particles of polymeric microfiber material nano-particles of the composition Al/Zn and Al/AlN/Zn and the products of their reaction with water is evenly distributed over the surface of polymeric microfibers and in the amount of fibrous material.

Furthermore, the use of nanoparticles of the composition of the Al/Zn and Al/AlN/Zn as a precursor allows obtaining antiseptic sorption material in one stage of oxidation of the particles of Al/Zn and/or Al/AlN/Zn in water without additional treatments antimicrobial agent.

Investigation of the phase composition of multicomponent nanoparticle composition of Al/AlN/Zn showed the presence of several phases, including phases of individual metals Al, Zn, and aluminum nitride (table 1).

Table 1
Physico-chemical characteristics of precursors and products of their transformation
No.PrecursorCharacteristics of the precursorCharacteristics of the reaction products
CAl% mParticle size, nmSUD, m2/gPhase compositionSUD, m2/gPhase composition
1Al/AlN/Zn508015Al, Zn, AlN229Al2O3, AlOOH, ZnO
2Al/Zn5010012Al, Zn233Al2O3, AlOOH, ZnO

A study of the morphology of the reaction products mentioned nanosized powders with water showed that they represent �Wallpaper agglomerates of nanoplastic hydrate of aluminum oxide with inclusions of hexagonal plates of zinc oxide. The hydrolysis products are mesoporous adsorbents with a pore size of 4-10 nm, a pore volume 0,45-0,65 cm3/g and a specific surface area of 200-280 m2/g for the samples obtained by the hydrolysis of Al/AlN/Zn and Al/Zn, respectively (table 1).

Aluminum and aluminum nitride included in the composition of multicomponent nanoparticles react with water with the formation of fibers on the base (non-woven microfibrous polymeric material) porous agglomerates of nanoplastic of pseudoboehmite, is able to adsorb the microorganisms, biological molecules, organic compounds.

Zinc, which is a component of nanoscale particles, reacts with water with the formation of fibers on the basis of hexagonal plates or agglomerates plates (zinc oxide) and provides anti-inflammatory, wound healing, absorbent, astringent and antiseptic dressings.

The resulting material can be used for the production of dressings for the treatment of superficial wounds of various etiology - surgical, burns, chronic wounds (venous and diabetic ulcers, bedsores, etc.), including infected.

The invention is further confirmed by examples of specific performance and graphic materials.

Fig. 1 and 2 shows SEM-images of polymeric microfibers-modified ALOM�retumi of the analista pseudoboehmite and hexagonal plates of zinc oxide at different magnification.

Fig. 3 shows the diffraction patterns are products of the transformation of Al/AlN/Zn (1) and Al/Zn (2).

Fig. 4. The curves of the antimicrobial activity of the samples antiseptic sorption material obtained on the basis of multicomponent nanoparticles: 1 - Al/AlN/Zn, 2 - Al/Zn and the prototype: 3 - Al/AlN (Ag).

Examples of the method.

The pre-selected samples microfibrous polymeric material of 50×50 cm and a thickness of 1 mm, made of cellulose acetate polysulfone and polypropylene (diameter acetate-cellulose and polisul fibers of 1.5-3 mm, polypropylene - 8-10 μm) were modified to improve their adhesion properties, determined by the roughness and wettability. To this end, the samples were placed between the electrodes of the laboratory setup for atmospheric plasma activation and surface modification of materials. Processing was performed in the continuous generation of pulses when the amplitude of the output voltage of 56 kV, duration of the pulse front 10 NS, pulse width (FWHM) of 40 NS. The treatment was performed for 2-10 min After treatment of the polymer material by atmospheric plasma contact angle is changed: for the polymeric material is cellulose acetate from 65 to 50 degrees, for polysulfone - from 79 to 51 degrees, for polypropylene from 92 to 52 degrees.

Example 1.

Methods�the IR receiving antiseptic sorption material using as a precursor of nano-particles of the composition of the Al/AlN/Zn.

Sample microfibrous polymeric material of cellulose acetate, previously modified by atmospheric plasma was treated with a 1% aqueous suspension of the nanopowder Al/AlN/Zn, the rate of 0.9 l of suspension per 1 m2fibrous base, then heat treatment was carried out - the reaction with water at the linear heating from 20 to 60°C with heating rate 5 deg/min When the preset temperature of 60°C the sample thermostating in isothermal conditions for 20 min. Then the samples were dried at 105°C for 4 hours. The specific surface antiseptic sorption material was 89 m2/G. Before conducting microbiological studies have steam sterilized samples antiseptic sorption of a material at 121°C for 20 min (sample 1, table 2).

Example 2

The method of obtaining an antiseptic sorption material Al/Zn.

Samples microfibrous polymeric material of polysulfone size of 50×50 cm, modified atmospheric plasma was treated with a 1% aqueous suspension of nanopowders Al/Zn (sample 2, table 1), at the rate of 0.9 l of suspension per 1 m of the fibrous basis, then carried out the reaction with water at the linear heating from 20 to 80°C with heating rate 10 deg/min When the preset temperature of 80°C the sample thermostating for 40 min, Then the samples �took at 105°C for 4 hours. The specific surface antiseptic sorption material was 91 m2/G. Before conducting microbiological studies have steam sterilized samples antiseptic sorption of a material at 121°C for 20 min (Sample No. 2 of table 2).

Example 3.

The method of obtaining an antiseptic sorption material using as a precursor of nano-particles of the composition of the Al/AlN/Zn.

Sample microfibrous polymeric material polypropylene, previously modified by atmospheric plasma was treated with a 1% aqueous suspension of the nanopowder Al/AlN/Zn, the rate of 0.9 l of suspension per 1 m2fibrous base, then heat treatment was carried out - the reaction with water at the linear heating from 20 to 60°C with heating rate 5 deg/min When the preset temperature of 60°C the sample thermostating in isothermal conditions for 20 min. Then the sample was dried at 105°C for 4 hours. The specific surface antiseptic sorption material was 86 m2/G. Before conducting microbiological studies have steam sterilized samples antiseptic sorption of a material at 121°C for 20 min (sample 3, table 2).

Example 4.

Study of sorption characteristics in relation to various microorganisms morphologists� and toxic effects of oxyhydroxides of metals, obtained by the hydrolysis of multicomponent nanoparticles.

Method for determination of antimicrobial action of the sorbent material. Quantitative assessment of antimicrobial activity of the samples antiseptic sorption material was performed on the culture 7935 E. coli in vitro. For this purpose, samples of antiseptic sorption material obtained according to example 1, where the precursor used nanopowder Al/AlN/Zn (sample 1) or Al/Zn (sample 2) with a diameter of 47 mm was applied to 1 ml of culture of the microorganism E. coli 7935 concentration of 1.0×105CFU/ml until complete absorption of the suspension. The samples were incubated at a temperature of (37±1)°C for 24 h. Then the bacteria with the dressing material was suirable shaking in bottles with 100 ml of physiological solution (pH of 7.2) and inoculated with 1 ml suspension on nutrient agar (Endo RM) in Petri dishes. The inoculations were incubated at a temperature of (37±1)°C during the day, counted the number of colonies and calculated the percentage loss of microorganisms in the contaminated sample. As control was used a suspension of microorganisms in saline solution.

In Table 2 and Fig. 3 comparative evaluation of the antimicrobial activity of the samples antiseptic sorption material, for which a precursor used the multicomponent nanoc�or particles: 1 - Al/AlN/Zn, 2 - Al/Zn, 3 - Al/AlN (Ag) (prototype).

1. Antiseptic sorption material intended for the production of dressings for treatment of wounds, representing a microfibrous matrix attached to fibers dispersed sorbent, characterized in that a particulate sorbent it contains highly porous particles of hydrate of aluminum oxide particles and zinc oxide, wherein the amount of the sorbent particles is from 15 to 45%.

2. Material according to claim 1, characterized in that the microfiber matrix polymer selected microfiber material obtained by molding from a solution or melt of polymer technology spunbond, meltblown or method of electrotorture cellulose acetate, polysulfone or other bioinert polymer having a fiber diameter of 0.1-10 microns, preferably 1-3 microns.

3. Material according to claim 1, characterized in that the highly porous particles of hydrate of aluminum oxide are agglomerates formed by neoplastically of pseudoboehmite, and the particles of zinc oxide are mainly agglomerates of plates of zinc oxide.

4. Material according to claim 3, characterized in that the agglomerates of nanoplastic of pseudoboehmite and agglomerates of plates of zinc oxide have an extensive misopristol, with a pore size of from 4 to 10 nm and a pore volume of from 0.5 to 0.65 cm 3/g, and specific surface area lying in the interval from 200 to 280 m2/g.

5. Material according to claim 1, characterized in that the highly porous agglomerates of particles of hydrate of aluminum oxide and agglomerates of particles of zinc oxide uniformly distributed on the fibers and to the extent the microfiber matrix.

6. Material according to claim 1, characterized in that the weight ratio of highly porous particles of hydrate of aluminum oxide and particles of zinc oxide is from 5:95 to 95:5.

7. Material according to claim 1, characterized in that its specific surface area lies in the interval from 70 to 100 m2/g.

8. Material according to claim 1, characterized in that said material further comprises at least one layer of atraumatic material intended for placement on the wound surface.

9. Material according to claim 8, characterized in that said material further comprises at least one layer of protective material, located either on one or on both sides.

10. Bandage for treatment of wounds, has anti-inflammatory, wound healing, absorbent, astringent and antiseptic effect, containing at least one layer of the above-mentioned material according to any one of claims. 1-9 and at least one layer of protective material, located either on one or on both sides.

11. Pova�according to claim ka 10, characterized in that it further comprises elements for fixing it to the body of the person.

12. A method of producing antiseptic sorption material according to claim 1, comprising the following steps:
- select the microfiber matrix, obtained by the method of electrotorture cellulose acetate, polysulfone or other bioinert polymer with fiber diameter in the range from 0.1 to 10 μm, preferably from 0.5 μm to 3.5 μm;
- modification of selected microfibrous matrix atmospheric plasma to improve its adhesive properties;
- impregnation of the modified microfibrous matrix with a suspension containing precursor dispersed sorbent: multicomponent nanosized particles of composition defined by the formula Al/Zn or Al/AlN/Zn phase comprising aluminum and zinc;
- implementation of thermal treatment of polymeric microfiber material impregnated with the above-mentioned slurry for forming the adhesion and fixing of the particles of the sorbent on the fibers and to the extent the microfiber matrix.

13. A method according to claim 12, characterized in that the modification of polymeric microfiber material is carried out by low-temperature atmospheric plasma discharge with runaway electrons (ADRE-plasma).

14. A method according to claim 12, characterized in that the use of multicomponent nano-sized�the suspended particles, specific surface area ranging from 7 to 22 m2/g, preferably from 10 to 18 m2/g, and they are preferably obtained by the method of electric explosion of wire.

15. A method according to claim 12, characterized in that the heat treatment is initially carried out at the linear heating from 20 to 90°C at heating rate of 5 to 10 ° C/min, and then at a constant temperature lying in the range of 50 to 90°C, preferably from 60 to 80°C, and humidity from 60 to 95%.



 

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Corn plaster // 2454249

FIELD: medicine.

SUBSTANCE: invention refers to medical and chemical-pharmaceutical industry and is applicable in healthcare facilities and domiciliary for external application as a remedy in skin diseases: corns, plantar callosities, callules. A corn plaster contains salicylic acid, precipitated sulphur, anhydrous lanolin, pine rosin, lump rubber, dimethylsulphoxide, pine resion, petrolatum and agidol with salicylic acid used as micronised particles sized max. 30 mcm, and the ingredients taken in certain proportions. The experimental clinical findings have shown that the leukocytic mass applied on corns has an effect on adjoining skin areas causing no allergy, irritation or redness if the plaster is applied on healthy skin.

EFFECT: corn plaster improves keratolytic, antiseptic and antimycotic properties ensured by qualitative and quantitative composition of the ingredients.

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a haemostatic device for blood coagulation improvement which contains a gauze base, a clay material located thereon, and also polyol, such as glycerol or similar placed on the gauze base for binding the clay material. The device for bleeding wound management comprises at least a portion of the clay material contacting to blood flowing from the wound to cause coagulation. A dressing applicable on the bleeding wound for blood coagulation improvement comprises a flexible base and a gauze base located thereon. The gauze base comprises the clay material and polyol. Ahaemostatic sponge also contains a gauze basis and a disperse system of the haemostatic material and polyol on the first base surface. The invention also refers to N-substituted monomers and polymers, methods for producing such monomers and polymers and to methods for using for various medical purposes, e.g. in medical devices. In the preferential versions, a medical device represents a stent.

EFFECT: haemostatic device improves blood coagulation.

43 cl, 1 tbl, 9 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery, and is intended for pathogenically substantiated treatment of wounds of various etiology at the first stage of wound process. Described is application in wound covering of single complex from perforated cellulose Acetobacter xylinum and biologically active ingredients, which have therapeutic effect. Into wound covering included are complex fullerene C60/Tween-80 (antioxidant), antimicrobial component, antienzymatic and haemostatic component, necrolytic component.

EFFECT: due to wet medium supplied are optimal for wound reparation conditions, and due to application of perforated bacterial cellulose covering is vapour- and air permeable.

4 cl, 2 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. What is described is a transdermally absorbable formulation prepared by dissolving donepezil in an adherent plaster base, which contains a hydrophobic polymer and an absorption enhancer. The absorption enhancer represents one substance, or two or more substances specified in lauryl alcohol, triethyl citrate, isopropylmyristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethyleneglycol monostearate, lauromacrogol, N-methyl-2-pyrroldone and triacetin.

EFFECT: transdermally absorbable formulation can administer donepezil stably for a relatively long period of time and can provide both blood donepezil increase, and the properties of sustained release of donepezil.

4 cl, 4 dwg, 6 tbl, 26 ex

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