Flexible tube and product

FIELD: chemistry.

SUBSTANCE: invention relates to biopharmaceutical tube and product, including such tube. Flexible tube is made of mixture of polyolefin and block-copolymer based on styrene and plasticiser. Styrene-based block copolymer has configuration of blocks A-B-A and molecular weight at least about 350 kg/mol. Polyolefin and styrene-based block-copolymer are present in ratio about 1.2:1 to about 0.2:1.

EFFECT: manufacturing biopharmaceutical flexible tubes and products containing them, possessing improved operating characteristics of pumping.

13 cl, 6 tbl, 3 dwg

 

AREA of TECHNOLOGY

This invention relates in General to a flexible material for the tubes and to the products produced from the above-mentioned material.

The LEVEL of TECHNOLOGY

Currently the system is flexible medical tubing used to move any type of fluids during medical procedures. A typical material used for medical tubing because of its flexibility and translucency, flexible polyvinyl chloride (PVC). Unfortunately, the system of tubes of polyvinyl chloride has significant quantities of chemicals with low molecular weight which can be leached into the human body in the course of conservative treatment. Advanced disposal on the basis of PVC incineration causes the problems of the environment due to release of toxic gases.

For manufacturing systems flexible medical tubing was introduced materials, alternative flexible PVC. Polymers that may be desirable, generally include those which are flexible, transparent and suitable for certain applications. Unfortunately, these polymers may not have all the physical or mechanical properties, desirable for use in the system of the flexible medical tubing. For example, many of these polimerov have desirable resource pumping due to the strong exfoliation and pollution. Additionally, many of these polymers may not have transparency, it is desirable for the visualization of fluid flow through a system of tubes. As a result, manufacturers often have to choose their desired physical and mechanical properties without the possibility of choice with respect to whether they have the applicable service period.

Thus, an improved polymeric material is desirable.

DISCLOSURE of INVENTION

In a particular embodiment the flexible material for piping system includes a mixture of polyolefin and a block copolymer based on styrene, where the block copolymer based on styrene has a configuration blocks A-B-A and a molecular weight of at least about 350 kg/mol.

In another embodiment, the implementation of the product includes a mixture of polyolefin and a block copolymer based on styrene, where the block copolymer based on styrene has a configuration blocks A-B-A and a molecular weight of at least about 350 kg/mol.

BRIEF DESCRIPTION of GRAPHIC MATERIALS

The present disclosure may be better understood, and its numerous characteristic features and advantages made apparent to experts in the field by reference to the accompanying graphics.

Fig.1, 2 and 3 include microsemi illustrative tubes.

A DETAILED DESCRIPTION of the INVENTION

In particular �the Ariant of the invention, the product includes a polymer blend of a polyolefin and a block copolymer based on styrene. A mixture of polyolefin with a block copolymer based on styrene mainly provides a polymeric material that can be formed in such products, as a system of flexible tubes. In one example of a system of flexible tubes of polyolefin with a block copolymer based on styrene has desirable operating characteristics of the pumping. Additionally provide the polymeric material can be sterilized and welding.

Generally, block copolymers based on styrene are multiblock copolymers, such as diblock, tribloc, polyblock or any combination of them. In a specific embodiment of the block copolymer based on styrene is a tribloc is a copolymer having units of ABA. Typically, the units represent alkanolamine such as styrene, alpha-methylsterol, a couple of methylsterol, para-butalbiral or a combination of both. In a specific embodiment, the unit A represents styrene. In one of the embodiments of the unit B include alkenes such as butadiene, isoprene, ethylene, butylene, propylene, or a combination. In a specific embodiment, the units of B are ethylene, butylene, or combinations thereof.

Illustrative block copolymers based on styrene include block copolymers of styrene of three blocks (SBC) such as styrene-butadiene-styrene (SBS), styrene-isopr�n-styrene (SIS), styrene-ethylene-butylene-styrene (SEBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-ethylene-butadiene-styrene (SEEBS), styrene-ethylene-ethylene-propylene-styrene (SEEPS), styrene-isoprene-butadiene-styrene (SIBS), or combinations thereof. In a specific embodiment of the block copolymer based on styrene is a styrene-ethylene-butylene-styrene (SEBS). Industrial examples include some types of resins Kraton™ and Hybrar™. In one of the embodiments of the block copolymer based on styrene is saturated, i.e. it does not contain any free of olefinic double bonds. In one of the embodiments of the block copolymer based on styrene contains at least one free olefinic double bond, i.e. an unsaturated double bond.

Typically, the block copolymer based on styrene has a molecular weight of at least about 350 kg/mol. In a specific embodiment of the block copolymer based on styrene has a molecular weight of from about 350 kg/mol to about 500 kg/mole. In one of the embodiments of the block copolymer based on styrene has a viscosity of at least about 0.1 PA·s, such as from about 0.30 to about 0.35 PA·s, as measured in solution in toluene at 5 weight percent at 25°C.

In one of the embodiments of the block copolymer based on styrene is present in amounts of at least 10% by weight, such as �least about 20% by weight or even at least 30% by weight of the total weight of the polymer. In one of the embodiments of the block copolymer based on styrene is present in an amount of from about 10% by weight to about 50% by weight, such as from about 15% by weight to about 30% by weight or even from about 20% by weight to about 30% by weight of the total weight of the polymer. Typically, the level present in the polymer mixture of a block copolymer based on styrene can be optimized based on the desired end properties.

In a specific embodiment of the polymer mixture comprises a polyolefin. Typical polyolefin may include a homopolymer, copolymer, terpolymer, a mixture of polymers and copolymers, or any combination thereof, formed from a monomer, such as ethylene, propylene, butene, Panten, methylpentene, octene, or any combination of them. Illustrative polyolefin comprises high density polyethylene (HDPE), medium density polyethylene (MDPE), low density polyethylene (LDPE), polyethylene, ultra-low or very low density (VLDPE), a copolymer of ethylene and propylene, a copolymer of ethylene and butene, polypropylene (PP), polybutene, polybutylene, polypenco, polymethylpentene, polystyrene, ethylene-propylene rubber (EPR), a copolymer of ethylene and ökten, blend, mixture, etc., Polyolefin further comprises a random copolymer based on olefin, high impact copolymer based on olefin, block copolymers on main�ve olefin, special elastomers based on olefin, special plastomer based on the olefin, mixtures thereof, etc., In one of the examples of the polyolefin comprises polypropylene. In a specific example, the polyolefin is a statistical copolymer of polypropylene. In one of the embodiments of the polyolefin is a stabilized gamma rays polypropylene. Commercially available examples of polyolefins include polyethylene, elastomers on the basis of polyethylene, such as Engage™, provided by Dow Chemical Co., and polypropylene, elastomers based on polypropylene, such as Versify™, provided by Dow Chemical Co., Vistamaxx™ provided by Exxon Mobil Chemical, statistical copolymers of polypropylene provided by Flint Hills Resources, etc.

The polyolefin may include any reasonable supplements. In particular, the polyolefin may include the impact resistance modifier and additives such as heat stabilizer, antioxidant, ultraviolet radiation stabilizer, clarifying agent, lubricant, wax, antistatic agent, or a combination. Illustrative stabilizers radiation include light stabilizers based on sterically obstructed amines (HALS) such as Tinuvin 770, supplied by CIBA. Illustrative impact modifiers include such polyolefin elastomer, Engage®, which is a polyethylene, modified�yovanny with butene or hexene as comonomer. Typically, the composition of the additives in the polyolefin is present in an amount of not more than about 1% by weight, the impact resistance modifier in the polyolefin is present in an amount of not more than about 10% by weight, or even no more than about 5% by weight of the total weight of the polyolefin.

In one of the embodiments of the polyolefin is present in the mixture in an amount of at least 10% by weight, such as at least about 20% by weight or even at least about 30% by weight of the total weight of the polymer. In one of the embodiments of the polyolefin is present in the mixture in an amount of from about 10% by weight to about 50% by weight, such as from about 15% by weight to about 30% by weight or even from about 20% by weight to about 30% by weight of the total weight of the polymer. Typically, the level present in the polyolefin polymer mixture can be optimized based on the desired end properties.

In one of the embodiments of the polyolefin and a block copolymer based on styrene in the mixture are used in a ratio with optimum properties based on the desired end properties. For example, a polyolefin and a block copolymer based on styrene may be present in a ratio of from about 1.2:1 to about 0.2:1.

In one of the embodiments in the polymer mixture may contain a plasticizer. In particular variationbetween plasticizer is an oil. You can include any suitable oil. In a specific embodiment of the oil is a mineral oil, i.e. paraffins, naphthenes such or a mixture thereof, is essentially zero content of aromatic compounds. In a specific embodiment of the mineral oil can be used in an amount of from about 0% by weight to about 70% by weight of the total weight of the polymer. In one of the embodiments of a mixture of essentially do not contain plasticisers. "In fact contains no plasticizers", as used herein, refers to a mixture that includes mineral oil present in an amount less than about 0.1% by weight of the total weight of the mixture. For example, block copolymers based on styrene can be processed in the melt without the addition of extender oil or plasticizer.

In the illustrative embodiment of the polymer mixture additionally comprise any additive contained in the materials to improve the adhesiveness, heat stabilizer, lubricant, filler, an antioxidant, or any combination thereof. Illustrative heat stabilizers include Iraganox 1010 supplied by Ciba. Illustrative materials to improve adhesiveness include copolymers of vinyltoluene and alpha-methyl styrene, and styrene and alpha-methylstyrene. Illustrative material for enhancement� tack includes Piccotex®, provided by Eastman Chemical Company. Illustrative lubricants include silicone oil, waxes, slip additives, mould release, etc., Illustrative of the lubricant further comprises a grafted copolymer of silicone and polyolefin, polyethylene or polypropylene waxes, amide, oleic acid, erucamide, stearate, esters of fatty acids, etc. generally, the lubricant may be present at less than about 2.0% by weight of the total weight of the polymer. In one embodiment of the lubricant may be present at less than about 0.5% by weight of the total weight of the polymer. Illustrative antioxidants include phenol such, antioxidants based on sterically obstructed amines, combinations thereof, etc. Illustrative fillers include calcium carbonate, talc, radioprotecao fillers, such as barium sulfate, bismuth oxychloride, and combinations thereof, etc. generally, the filler may be present in an amount of not more than about 50% by weight of the total weight of the polymer, as, for example, not more than about 40% by weight of the total weight of the polymer mixture, or even not more than about 30% by weight of the total weight of the polymer. Alternatively, the mixture may not contain additives such as substances for improving adhesiveness, heat stabilizers, lubricants, fillers and antioxidants.

For �of formirovaniya of the polymer components of the mixture of polyolefin and a block copolymer based on styrene can be processed by any known method. In one of the embodiments of the polyolefin and a block copolymer based on styrene can be processed in the melt by dry mixing or preparation. Dry blending may be powdery, granular or pelletized form. The mixture can be produced using a continuous process in a twin-screw extruder or a batch process in Bunbury. For the manufacture of such products as flexible products in the form of a system of tubes, tablets of these mixtures can be transferred in a single screw extruder. The mixture may also be mixed in a single screw extruder, equipped with mixing elements, and then ekstradiroval directly in products such as products in the form of a system of tubes. In a specific embodiment of the mixture can be processed in the melt by using any of the provided known in the field of methods, such as layering, casting, molding, extruding, etc., In one of the embodiments, the mixture may be subjected to molding.

The polymer mixture may advantageously be able to withstand sterilization processes. In one embodiment of the polymeric mixture can be sterilized by any prescribed method. For example, the polymer mixture is sterilized after the formed product. Illustrative methods �terilization include techniques such by means of steam, gamma radiation, ethylene oxide, electron beam, combinations thereof, etc., In a specific embodiment of the polymer mixture is sterilized by irradiation with gamma rays. For example, the polymer mixture can be sterilized by gamma radiation at from about 25 kGy to about 50 kGy. In a specific embodiment of the polymer mixture is sterilized by steam sterilization. In the illustrative embodiment of the polymer mixture is heat resistant to steam sterilization at temperatures up to about 130°C for a period of time up to about 45 minutes. In one embodiment of the polymer mixture is heat resistant to steam sterilization at temperatures up to about 135°C for a period of time up to about 15 minutes.

In one embodiment of the polymer mixture can be welded. That is, "welding" and "seal" may be used interchangeably and refer to the connection by welding of the two parts of the product formed from the polymer mixture. Advanced welding includes the operation of the seal on the plane, as well as the operation of the ring seal to be applied in respect of the piping system. The energy usually used for parameters that are sufficient to provide a seal which can withstand the test of the integrity of the seal under pressure with an air pressure of about 30 psi in those�Linux for about 30 minutes under conditions of dryness and humidity. You can include any other methods of welding/sealing, for example welding, heating, vibrasphere, ultrasonic welding, welding with infrared heating, radio-frequency welding (RF), combinations thereof, etc.

In one embodiment of the polymeric mixture can be formed in a single layer product, multi-product, or you can peel back the layers, to cause him a coating or forming on a substrate. Laminated products may include layers such as reinforcing layers, adhesive layers, barrier layers, chemically resistant layers, metal layers, any combination thereof, etc., the Mixture can be molded in any applicable form, such as film, sheet, tubing, etc., the Polymer mixture can be concatenated or linked to other substrates, including polyolefins (polypropylene (PP), polyethylene (PE), etc.) and styrene compounds (polystyrene (PS), Acrylonitrile-butadiene-styrene (ABS), high strength to dynamic and impact polystyrene (HIPS), etc.).

In a specific embodiment of the polymer mixture can be used in the receiving system of pipes and hoses. For example, the polymer mixture can be used as a system of tubes or hoses in obtaining low-toxicity system of hoses pumps, systems reinforced hose system chemical resistant hoses, braided system of hoses and pipe system and hose�s with low permeability. The system of tubes includes an inner surface that defines a Central lumen of the tube. For example, there may be provided a system of tubes, which is of suitable diameter size applicable to the particular selected application. In one embodiment of the system of tubes may have an outer diameter (OD) up to about 5.0 inches, such as about 0.25 inch to 0.50 inch and 1.0 inch. In one embodiment of the system of tubes may have an inner diameter (ID) of about 0.03 inches to about of 4.00 inches, such as from about 0.06 inch to about 1.00 inch. The system of pipes from polymer mixture predominantly exhibits desirable properties such as increased durability. For example, the tube may have a resource pumping more than about 100 hours, such as more than about 150 hours or even more than 200 hours, as measured at 600 rpm using a standard nozzle L/S 17 peristaltic pump, Cole-Parmer and water as the working fluid of the pump.

In one of the embodiments of the system of tubes produced using the polymer mixture has the desirable wear characteristics of the tube, such as minimum flaking (internal) and pollution (outdoor). In particular, exfoliation results in the formation of particles and debris in the line current, and pollution results in � tackiness and stickiness of the nozzle to the pump. In a specific embodiment, the wear characteristics of the tubes have a value of exfoliation and impurities comprising less than about 1.0% weight loss when tested using a standard nozzle L/S 17 peristaltic pump, Cole-Parmer. Additionally, the resource handling is a data set that has the minimum statistical variability, as indicated by the standard deviation, which constitutes less than about 10% of the median or average of data. In one embodiment of the flexible tube made of polymeric material has a reduced volume flow, amounting to less than 50%, such as less than about 30% of the original starting value.

In one embodiment of the implementation of the resulting products may have additional desirable physical and mechanical properties. For example, products are flexible, resistant to fracture and look transparent or at least translucent. For example, the product may have a light transmission of more than about 2% or more than about 5% in the wavelength range of visible light. In particular, the resulting products have desirable flexibility and significant transparency or translucency. For example, the polymeric mixture is predominantly possible to obtain products with low values �vergoti on the scale of hardness. For example, we can form a product having a hardness value on a scale Durometer shore A of about 35 to about 75, such as, for example, from about 55 to about 70, having desirable mechanical properties. Such properties indicate the flexibility of the material.

In addition to the desirable hardness of the product have a preferential physical properties, such as the balance of any one or more properties of hardness, flexibility, surface lubricity, resource handling, exfoliation, pollution, tensile strength, tensile, elongation, hardness shore A, resistance to gamma radiation, the strength of the weld and the integrity of the seal, at the optimal level.

In one embodiment of the implementation of the resulting product has the desired properties of thermal stability. In a specific embodiment, the implementation of the resulting product has one of the following properties of heat resistance, such as higher resistance to piercing, higher softening temperature or a higher temperature autoclaving compared to currently available commercial products.

The way of application of the polymer mixture are numerous. In particular, the polymer mixture is non-toxic, making the material applicable for any prima�t, where desirable, the absence of toxicity. For example, a polymer mixture essentially do not contain plasticizers or other additives with a low molecular weight, which can be washed out in the liquid, which they migrated. "In fact does not contain" as used herein refers to radiation cross-linked product having a total organic content (TOC) (measured according to ISO 15705 and EPA 410.4) constituting less than about 100 parts per million. Advanced polymer compound has biological compatibility and ingredients that do not contain ingredients derived from animals. For example, the polymer mixture is promising from the point of view of the FDA, USP, EP, ISO and other permissions from regulatory bodies. In the illustrative embodiment of the polymeric mixture can be applied in such applications, in industry, in medicine, healthcare, Biopharmaceuticals, pharmaceuticals in drinking water, in food and beverages, in laboratories, in the dairy farm, etc., In one embodiment, the implementation from the polymer mixture also can be safely get rid of, because it essentially does not form toxic gases when burning and leaches plasticizers in the environment when placed in a landfill.

EXAMPLES

A mixture of a block copolymer based on styrene and the polyol�ina

A mixture of polyolefin and a block copolymer based on styrene is made of the following components, as shown in table 1 (New members). The following ingredients of the recipe were subjected to dry mixing to homogenize the mixture, which was then in the melt using a twin-screw extruder. The thus obtained tablets are either manufacturing of these tubes by extrusion through a single screw extruder or injection molding.

Table 1
The new compositionWt.%
Resin based on SEBS22
Oil54
Polypropylene22,9
Silicone modifier1,0
Irganox 10100.1

Resin based on SEBS has an average block ethylene-propylene rubber and terminal blocks of polystyrene. Molecular weight SEBS is at least 350 kg/mol. Polypropylene is produced Flint Hills Resources, i.e. it is a statistical copolymer, which is shockproof and one hundred�alizirovannaya radiation. Mentioned above, the oil is a mineral oil is permitted for use USP. Irganox 1010 is a thermal stabilizer. The mixture yields optically transparent product. In the following table 2 shows the test data of the physical properties for the New structure.

Table 2
The new compositionThe nominal value
Shore hardness65A
The limit of the tensile strength at 100%340 psi
The limit of the tensile strength at 300%470 psi
The limit of the tensile strength at break955 psi
Elongation at break690%

The above-described recipe was subjected to manufacture by extrusion system tubing size is 0.250"×0,380". Sterilization by gamma irradiation occurs at around 40 to 50 kGy, and autoclaving at about 121°C for about 30 minutes. The nominal values of the properties measured are contained in table�e 3 for comparison. As a control, apply current commercial offer thermoplastic elastomer (TPE) provided by Saint-Gobain Performance Plastics. Also in the data set include competing system of tubes that make up the competition on the pumping characteristics. The elongation at break is determined by the Instron device in accordance with the test methods ASTM D-412. Resource handling is measured on a standard nozzle L/S pump Cole-Palmer. Tensile strength (limit of tensile strength at break) are measured in accordance with ASTM D412. Inner wear (exfoliation), outer wear (pollution) and reduce the consumption is measured on the peristaltic pump, Cole-Parmer standard nozzle L/S 17, rotating at 600 rpm.min., and water as the working fluid of the pump.

Table 3
Current TRECompeting tubingThe new composition
The value of shore606665
Tensile strength (psi) before/after �terilization gamma rays 800/8001018/NDA955/760
Elongation at break (%) before/after sterilization by gamma irradiation720/740590/NDA690/700
Resource pumping (average/standard deviation in hours) during sterilization by gamma irradiation is Stopped/Denied7/8 Denied91/54 Denied207/11 Stopped
The inner and outer wear tube (wt.%) during sterilization by gamma irradiationNDA3,70,48
The consumption decrease from the beginning, %It is impossible to measure due to peelingIt is impossible to measure due to peeling30

As can be seen from table 3, the New composition, surprisingly, has the best performance, in particular, resource handling, internal and external wear of the tube and reducing consumption than current TPE and competing system of tubes. In particular, the use of polymer mixtures of the New SOS�ava provides a resource of transfer, improved by more than about 127% compared with competitors. Additionally, the inner and outer wear of the tube is reduced by about 87% compared with a competitor. As presented in the table above, the New composition has much less variability in the data set compared to the other 2 samples.

New membership experience on its transparency. The composition is not opaque, but is translucent, as indicated by the data presented below in table 4. In particular, it has good contact transparency, which means that the system tubing made from the composition, shows the visualization through the tube while filling it with liquid.

Table 4
The wavelength of visible light, nmCurrent TREThe new composition
Light transmission, %
70029,7a 5.4
40013,92,3

Abrasion testing performed by the test plates on the car Plint at a speed of 10 Hz, the weight of the load of 50 N and p�not move in 7 mm ball 440 SS 3/8 inch. Testimony is taken within 10 minutes with readings at 1 minute, 5 minute and 9 minutes. Measurement and testing was done in accordance with ASTM G133. The results can be seen in tables 5 and 6.

Table 5
TimeCurrent TREThe new composition
The coefficient of friction (CoF)
1 minute0,1780,079
5 minutes0,1040,077
9 minutes0,1480,072
Average0,1430.076 mm

4,974
Table 6
Weight (g)Current TREThe new composition
Wear (weight loss, %)
Weight before4,199
Weight after4,9134,199
Weight loss, %mind-boggling 1,224%0,000%

Although this is not a theory, it is theorized that the superior performance of the pumping transparent system of tubes of thermoplastic elastomer (TPE), such as a New composition, related to their natural characteristics of a good smazyvaete. This is supported by the wear test and the visual confirmation of the test samples. The new composition shows no wear that is evident from loss of weight and lack of abrasion of the material. In addition, the measured characteristic of the coefficient of friction (CoF), and a lower number for the New composition indicates that the surface is smoother than the standard, the current TRE.

Analyze the morphological properties of samples of a system of tubes New composition and 2 are currently available, TRE (TRE 1 and TRE 2). The phase morphology is studied using atomic force microscopy (AFM). The cross section of each sample piping system gain so that the image was shot in a plane perpendicular�nd the direction of extrusion. Samples were cut on a freezing microtome with a diamond knife, maintained at -150°C for surfaces subjected to cryogenic treatment, for analysis using a Veeco MultiMode AFM. Applied silicon cantilevers with a nominal resonance frequency of 190 kHz with medium-weak forces push the probe in tapping mode, characterized by the free amplitude of 4.0 and B control point, the reduction ratio of 0.9. Microsemi results can be seen in figures 1, 2 and 3.

As you can see from the images, microsemi TRE 1 (Fig.1) and the TRE 2 (Fig.3) are similar and show the morphology of the type of continuity of the different phases, or inter-penetrating network (IPN), where both phases, the oil-containing polypropylene and SEBS, coexist and have a three-dimensional spatial integrity. These images are in sharp contrast with that of the New composition (Fig.2), which demonstrated the morphology of the droplets, where the oil-containing SEBS exists in the form of large domains dispersed in the polypropylene matrix. It is clear that the morphology of the New composition is not a such type of continuity of the different phases, but rather a block copolymer based on styrene has both large and small discrete domains dispersed within a continuous polyolefin matrix.

The new composition has markedly better performance Perek�of zivania, than current formulations TRE. Although this is not a theory, it is theorized that the morphology of the New composition provides improved operating characteristics of the pumping compared to existing formulations TPE. Also the New composition is a TPE that has operating characteristics of the pump, similar to those of the system tubing made from compositions of thermoplastic vulcanizate (TPV). The phase morphology of the New composition has similarities with the phase morphology of the TPV that TPV contains polypropylene as a continuous matrix and particles of cross-linked rubber as a discrete phase.

It should be noted that not all of the steps described above in the General description or the examples are needed, what specific part of the action may not be necessary and that it is possible to perform one or more additional actions in addition to those described. Moreover, the order in which these steps, not necessarily the order in which they are executed.

In the above description of the concept described with reference to specific implementation options. However, any of the medium-specialists in the art taking into consideration that can be made a variety of modifications and changes without the sludge�came from the scope of the present invention, as shown below in the claims. Accordingly, the description and the figures should be considered illustrative rather than restrictive sense, and all such modifications are intended to be included within the scope of the present invention.

1. Biopharmaceutical flexible tube of a mixture of polyolefin and a block copolymer based on styrene and plasticizer, where the block copolymer based on styrene has a configuration blocks A-b-A and a molecular weight of at least about 350 kg/mol, where the polyolefin and a block copolymer based on styrene are present in a ratio of from about 1.2:1 to about 0.2:1.

2. The flexible tube of claim 1, wherein block a is a styrene, alpha-methylsterol, a couple of methylsterol, para-butalbiral or a mixture thereof.

3. A flexible tube according to any of claims. 1-2, where the block includes butadiene, isoprene, ethylene, butylene, propylene, or combinations thereof.

4. A flexible tube according to claim 1, wherein the polyolefin includes polyethylene, polypropylene, polybutylene, polymethylpentene, a random copolymer based on olefin, high impact copolymer based on olefin, block copolymers based on olefin, special elastomers based on olefin, special plastomer based on the olefin, or mixtures thereof.

5. A flexible tube according to claim 4, wherein the polypropylene is a statistical copolymer of polypropylene.

6. A flexible tube according to claim 1, where polio�even further comprises a radiation stabilizer and an impact resistance modifier.

7. A flexible tube according to claim 1, wherein the mixture further comprises a plasticizer.

8. A flexible tube according to claim 1 having a hardness value on a scale Durometer shore A of about 35 to about 75.

9. A flexible tube according to claim 1 having biological compatibility and ingredients that do not contain ingredients derived from animals.

10. A flexible tube according to claim 1, having a light transmission of more than about 2% in the wavelength range of visible light.

11. A flexible tube according to claim 1, which is sterilized.

12. The flexible tube of claim 1, wherein the block copolymer based on styrene has a phase morphology drops, domains, or combinations thereof, dispersed in a matrix of polyolefin.

13. The product, including biopharmaceutical flexible tube of a mixture of polyolefin and a block copolymer based on styrene and plasticizer, where the block copolymer based on styrene has a configuration blocks A-b-A and a molecular weight of at least about 350 kg/mol, where the polyolefin and a block copolymer based on styrene are present in a ratio of from about 1.2:1 to about 0.2:1.



 

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20 cl, 8 dwg

FIELD: machine building.

SUBSTANCE: elastic mandrel is formed in the form of tight chamber formed with closed elastic cylindrical cover from vulcanised material with ends. Ends are rigidly fastened with bolt connections between two fixed cylindrical shells and two movable cylindrical flanges, which are concentrically installed on central hollow rod. Distance between flanges is equal to length of flexible tube located between elastic mandrel and radial deformation limiter. Limiter is made from fabric in the shape of cover made as detachable cylinder. Elastic cover is arranged coaxially on cylindrical surfaces of shells. Air is pumped through nozzle located on the edge of one of the shells to tight chamber of mandrel till elastic cover forms cylindrical frame of mandrel equal to inner diameter of flexible tube. Multi-layer flexible tube is assembled from industrial rubber materials on the formed mandrel. Radial deformation limiter is installed coaxially to flexible pipe on its external wall. Pressure test is performed prior to flexible tube vulcanisation by additional pumping of air through nozzle to tight chamber till the required pressure is created. Vulcanisation of pressure-tested tube is performed on elastic mandrel. After vulcanisation is completed, air pressure in mandrel chamber is released through nozzle till it looses frame structure. Limiter cloth is loosened on external wall of tube and the tube is removed from elastic mandrel.

EFFECT: simpler flexible tube manufacturing technology; higher reliability and quality; and reduction of metal consumption of cylindrical mandrel.

2 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to acrylic rubber compositions which are used to make industrial rubber products, e.g., rubber hose, sealing articles, rubber vibration insulators etc. The composition contains carboxyl group-containing acrylic rubber, a diazabicycloalkene compound, a polyamine compound and a tertiary amine compound of formula (1), where each of R1, R2 and R3 independently denotes a substitute containing at least one saturated aliphatic hydrocarbon or an unsaturated aliphatic hydrocarbon with a linear structure, a branched structure or a cyclic structure, or a benzyl group. The polyamine compound is an aromatic polyamine of formula (2): H2N-Ph-M-Ph-NH2 (2) where M denotes O, S, SO2, CONH or O-R-O; R in O-R-O is Ph, Ph-Ph, Ph-SO2Ph, (CH2)m, m ranges from 3 to 5, Ph-CH2-C(CX3)2CH2-Pn, where X is H or F, or (CH2)C(CH3)2(CH2); Ph denotes a benzene ring.

EFFECT: good curing parameters and excellent combination of processability, mechanical properties of rubber and compression set of acrylic rubber compositions and curing products thereof.

9 cl, 5 tbl, 18 ex

FIELD: transport.

SUBSTANCE: invention relates to brake drive compressed air feed multiplayer pipes. Said pipe has outer, intermediate and inner layers. Outer and inner layers consist of moulding bulk containing, at least, 40 wt % of polyamide. Polyamide monomer blocks contain, on the average, eight carbon atoms. Intermediate layer consists of moulding bulk containing 70 to 99 wt % of polyamide selected from PA6, PA66, PA6/66 and mixes thereof and 1 to 30 wt % of plasticiser. Not here that said moulding bulk of intermediate layer does not contain impact viscosity modifier. Pipe OD varies from 6 to 20 mm. Wall thickness varies from 1.0 to 2.0 mm. Polypropylene layer thickness makes 25-75% of wall thickness Layers may be jointed together by adhesion promoter layer with thickness varying from 0.02 to 0.2 mm.

EFFECT: efficient production of pipe with high resistance to penetration, impact viscosity and resistance to ageing.

3 cl, 1 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a polyamide resin-based composition consisting of a polyamide resin (A) as a matrix and a modifying polymer (C) dispersed in said matrix, having a functional group (B) which reacts with the polyamide resin (A), in which the tensile breaking stress of the modifying polymer (C) is between 30 and 70% of the tensile breaking stress of the polyamide resin (A) and tensile elongation at rapture of polymer (C) between 100 and 500% of the tensile elongation at rapture of the polyamide (A), as well as a pneumatic tyre and air hose made using the said composition.

EFFECT: composition has excellent expansibility and flexural fatigue.

8 cl, 7 tbl, 18 ex

FIELD: machine building.

SUBSTANCE: invention elates to field of manufacturing and operation of flexible high-pressure hoses (HPH), with tubular braiding, which can be used in area of feeding of liquids or gas under pressure in open or closed systems. High-pressure hose with composite braiding, of inner diametre 4-50 mm, contains internal tubular layer made of rubber, force framework made of two layers of braiding, herewith inner layer of braiding is implemented of pretensioned up to expansion 0.5-10% of fibers, is elastic fixed on external surface of internal tubular layer of hose by means of self-curing up to rubber-like condition of polymer compound, and external layer of braiding is implemented of pretensioned fibers up to expansion for 0.5-5% more, than fibers of internal layer of braiding, is saturated and coated with mentioned above polymer composition, herewith space between internal and external layers of braidings is filled by lubricant for 1-80%.

EFFECT: fabrication method of structure provides receiving of HPH with composite braiding with different technical and economic properties and do not requires application of vulcanisation process, application of additional technological layers or braidings, preparation for installation of end fittings.

15 cl, 1 dwg

FIELD: machine building.

SUBSTANCE: invention relates to piping systems, manufactured from polycrystalline statistical polymers of propylene and α-olefines. In piping systems, including at least one layer containing polycrystalline statistical polymer of propylene and from 0.2 up to 5% wt. 1-hexen and not necessarily iterative link, selected from ethylene and C4-C10 α-olefine, in amount in the range from more than 0 up to 9% mole polymer demonstrates wide chain-length distribution, expressed through ratio between middle-mass molecular weight and middle-numeral molecular weight , described by formula (I), in the range from 5 up to 11, chain-length distribution of unimodal type and level of hexen content-1 in fraction, allowing limiting viscosity index, equal or more than 3.3 dl/g, which is less than level of hexen content-1 in fraction, allowing limiting viscosity index, less than 3.3 dl/g.

EFFECT: development of method of receiving of piping systems manufactured from polycrystalline statistical polymers of propylene and α-olefine and method of receiving of polycrystalline statistical propylene and 1-hexen.

12 cl

FIELD: chemistry.

SUBSTANCE: invention relates to high-frequency composite dielectric materials used in antenna engineering and high-frequency transmission lines. The composite material comprises packed fluoroplast-4 powder with particle size of no more than 5 mcm, impregnated with binder. The binder used is epoxy resin with a curing agent. The epoxy resin is a product of condensation of epichlorohydrin and aniline in an alkaline medium, with viscosity of no more than 200 mPa·s, and the curing agent used has viscosity of no more than 40 mPa·s. Impregnation with binder is carried out under pressure and while evacuating the volume of the powder, followed by curing.

EFFECT: producing a dielectric material with low permittivity, low dielectric loss tangent and improved properties such as strength and modulus of elasticity in compression.

1 dwg, 1 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a product, namely to a power cable, which includes a semiconductor layer, containing a semiconductor polyolefin composition. The composition contains graphene nanoplates, where the average thickness of the graphene nanoplates is in the range from 1 nm to 50 nm, and their side diameter constitutes 200 mcm or less, and olefin polymer resin of the base. The composition for the power cable can additionally contain solid electroconductive filler, different from the graphene nanoplates. The application of the semiconductor polyolefin composition in the semiconductor layer of the power cable is also described. Improvement of electrical exploitation characteristics in the process of annealing at temperatures lower than the temperature of the polymer melting and the temperature dependence of specific volume resistance in comparison to the one that has place for the respective semiconductor polyolefin compositions based on carbon soot.

EFFECT: roughness of the surface of the semiconductor polyolefin composition for extruded samples constitutes 100 mcm and less.

14 cl 7 dwg, 2 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to the application of butyl ion-containing polymers or partially halogenated butyl ion-containing polymers for the reduction of a population and/or prevention of accumulation of organisms, at least, on the surface of products, in a composite material, and in a moulded product. The organisms can be represented by bacteria, algae, fungi, molluscs or arthropods. A butyl ion-containing polymer is obtained from, at least, one isoolefin monomer and, at least, one multiolefin monomer. The butyl ion-containing polymer contains a cationic nitrogen-containing functional group or cationic phosphorus-containing functional group. The invention also relates to a surface coating for products, containing the said butyl ion-containing polymer.

EFFECT: invention provides the effective reduction of the population size and/or prevention of accumulation of organisms on products.

28 cl, 1 dwg, 33 ex

FIELD: process engineering.

SUBSTANCE: invention relates to production of moulded articles containing polybutadiene and can be used in tire production as moulded strips for tire sidewalls or treads. Polybutadiene with content of cis-isomer over 95% and polydispersity lower than 2.5 is mixed with highly dispersed silicic acid and/or carbon black and with cross-linking agents, sulphur or sulphur donors, extra process additive and subjected to extrusion at 40-75°C.

EFFECT: higher quality of processing the mixes and quality of formed articles with lower rolling resistance and abrasion.

5 cl, 1 dwg, 2 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to thermoplastic moulding compounds. Described are thermoplastic moulding compounds, comprising: A) 10 to 98 wt % of a polyamide; B) 0.001 to 20 wt % of iron powder with particle size of at most 10 mcm (d50 value) and with a specific BET surface area of 0.1 to 5 m2/g according to DIN ISO 9277; C) 1 to 40 wt % of a halogen-free flame retardant from a group of the phosphorus- or nitrogen-containing compounds or P-N condensates, or a mixture thereof; and D) 0 to 70 wt % of other additives, where the total of the percentages by weight of components A) to D) is equal to 100%. The invention also describes use of said thermoplastic moulding compounds in making fibres, films and moulded articles, and fibres, films and moulded articles made from the thermoplastic moulding compounds.

EFFECT: providing thermoplastic polyamide moulding compounds, having improved heat aging resistance and good surface quality after heat aging, as well as mechanical properties.

10 cl, 3 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of increasing homogeneity of mixtures of polyethylene, intended for manufacturing moulded products, films, tubes, wires and cables. A mixture of polyethylenes contains three fractures (A), (B) and (C) of a homo- or a copolymer of ethylene and at least one comonomer C3-C10 with different molecular weights. The low-molecular fraction A) has the weight-average molecular weight Mw lower than 40 kg/mol, the highly-molecular fraction B) has the molecular weight Mw higher than 250 kg/mol and the fraction C) has the intermediate molecular weight with the weight-average molecular weight Mw from 100 to 200 kg/mol. The mixture of polyethylenes has a single peak of melting as determined by means of differential scanning calorimetry (DSC).

EFFECT: obtained mixtures of polyethylenes, due to the improved homogeneity, possess improved properties, in particular surface properties, good processability and good mechanical properties.

16 cl, 9 dwg, 4 tbl, 3 ex

FIELD: process engineering.

SUBSTANCE: invention relates to production of sand blend or moulded article. Sand blend is composed on the mix of polyamide and master batch containing carbonic acid, particularly, with phenols or alcohols, and polyether amide. Polyamide has end groups, at least 50% of the latter are composed of end amine groups. Polyamide amount makes 10-99 wt %. Amount of polyether amide in master batch makes 1-90 wt %. Polyamide end groups, at least 50% thereof, are composed of end amine groups. This mix is stored and transported, if required. This mix is mixed in the melt at shear stress. Fused mix is unloaded and hardened to get sand batch of moulded article. Said moulded article represents a channel, plate or film.

EFFECT: produced article features higher content of end amino groups, higher resistance to hydrolysis.

9 cl

FIELD: process engineering.

SUBSTANCE: invention relates to production of resilient noise-absorbing compositions based on polyurethanes and thermoplastic microspheres. Production of composition of polymer and powder filler comprises mixing of components, removal of gas inclusions and composition polymerization. Components are mixed in priming mould composed of hollow cylinder spinning about its axis. Power filler is composed of expanded microspheres used in amount of 1-2 wt % of composition weight.

EFFECT: accelerated removal of gas inclusions, decreased effects of lamination.

3 cl

FIELD: chemistry.

SUBSTANCE: invention relates to a composition, providing an active barrier for gaseous oxygen with short induction periods of oxygen absorption. The composition for a product with the reduced gas permeability contains a complex polyether, an ether and an ester copolymer and an oxidation catalyst, where the ether and the ester copolymer contains a zinc compound and at least one polyether unit, selected from the group, consisting of poly(tetramethylene ether) and poly(tetramethylene-co-alkylene ether), where the molecular weight of the said polyether unit is in the interval from approximately 200 g/mol to approximately 5000 g/mol and the said unit of polyether is present in a quantity from approximately 15 wt % to approximately 95 wt % of the said ether and ester copolymer. The invention additionally relates to the products, obtained from the composition, and the methods of obtaining the composition and products.

EFFECT: invention makes it possible to obtain the products, which have a short period of the oxygen absorption induction.

40 cl, 2 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to a mixture of polyphenylsulphone (PPSU) and polytetrafluoroethylene (PTFE) for manufacturing moulded products from a synthetic material, to a method of manufacturing the moulded products from the synthetic material and the application of the said mixture. The PPSU and PTFE mixture is characterised by the fact that the content of PTFE in the mixture constitutes from 1 to 15 wt %, and the content of PPSU in the mixture constitutes from 99 to 85 wt %. PPSU and PTFE are mixed with each other in an extruder at a temperature of 340°C. The obtained compound is granulated, granulate is extruded at a screw temperature from 370 to 390°C with obtaining the moulded products from the synthetic material. The obtained formed products from the synthetic material are applied as anti-wear tapes in pipelines for petroleum products.

EFFECT: obtaining the mixture for the production of tapes, reducing friction in pipelines for petroleum products.

8 cl, 12 ex

FIELD: chemistry.

SUBSTANCE: claimed invention suggests method of regulating structure of copolymer chain. Method of regulating structure of chain of copolymer of conjugated diene compound and non-conjugated olefin is realised in the following way. Introduction of conjugated diene compound in presence of non-conjugated olefin and polymerisation catalyst is regulated to regulate copolymer chain structure, and where polymerisation catalyst includes composite metallocene-based catalyst, represented by the following formula (A): RaMXbQYb … (A), where each of R independently represents non-substituted or substituted indenyl group, with R being coordinated with M, M represents lanthanide element, scandium or yttrium; each of X independently represents hydrocarbon group, containing from 1 to 20 carbon atoms, with X µ- being coordinated with M and Q; Q represents elements from group 13 in periodic table; each of Y independently represents hydrocarbon group, containing from 1 to 20 carbon atoms, or hydrogen atom, with Y being coordinated with Q; and each of a and b constitutes 2. Method of regulation of copolymer chain structure, where copolymer of conjugated diene compound and non-conjugated olefin is represented by copolymer of butadiene and ethylene, is realised, and butadiene or butadiene and ethylene in said method are introduced into polymerisation reaction, in which ethylene polymerisation was initiated, or into system of polymerization reaction, in which polymerisation of butadiene and ethylene was initiated, or into system of polymerisation reaction, containing ethylene-butadiene copolymer, in presence of ethylene and polymerisation catalyst in such a way as to obtain block-copolymer, statistic copolymer or gradient copolymer.

EFFECT: provision of regulation of monomer unit location in copolymer with application of particular metallocene catalysts.

9 cl, 6 dwg, 1 tbl, 4 ex

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