Composition for preparing antimicrobial coating

FIELD: medicine.

SUBSTANCE: what is described is a composition for an antimicrobial coating containing inorganic substance nanoparticles, an active substance, a binding agent and a solvent. As the inorganic substance, the composition contains silicone dioxide; the active substance is presented by a mixture of quaternary ammonium compound and chlorhexidine; the solvent is a mixture of ethyl cellosolve and butyl cellosolve; the binding agent is a mixture of polymethylphenylsiloxane resin and butyl/methyl methacrylate copolymer in the following proportions, wt %: butyl/methyl methacrylate copolymer 1.70-10.0, polymethylphenylsiloxane resin 5.0-20.0, silicone dioxide 0.5-3.0, chlorhexidine (20% aqueous) 3.0-8.0, quaternary ammonium compound 0.5-3.0, ethyl cellosolve 20.0-50.0, butyl cellosolve to 100%.

EFFECT: providing the water-stability of the long-action antimicrobial coating, ecological safety and applicability for porous surface finish.

4 cl, 5 tbl, 1 ex

 

The invention relates to medicine, being coated to ensure long lasting antimicrobial protection of porous surfaces, such as the plastered surfaces of walls and ceilings, concrete surfaces or surfaces that are made of natural or artificial stone, and metal and plastic surfaces, painted with water-emulsion or latex paints, ceramic surfaces, etc. and surfaces that will not allow contact with water, for example, from synthetic composite materials (MDF, Spending), wood materials, surfaces, colored chalk, lime or similar materials.

Known antimicrobial organic coatings produced by applying a film-forming antimicrobial agents, for example, in the form of varnish "Septopal (TU 9392-028-41547288-2004 "Tool for antimicrobial surfaces SEPTOPAL"), containing as an active ingredient additive polyhexamethylene guanidine hydrochloride (phmg), which is compatible with the other components of the paint composition chlorosulphurized polyethylene and solvent oil (nefras A) or in the form of coatings, such as anti-microbial paint "BIOGRAPH-2 (TU 2312-002-41547288-1999 "Enamel pentaftalevyh "BIOGRAPH-2") with the same active component-based pentaftalevyh enamel PF-115.

Known compositions of the possession is t a broad spectrum of bactericidal and fungicidal activity and can be used to handle various surfaces as a primer or topcoat. With the introduction of salts pgmg in paint compositions (paints) raises the problem of their compatibility with various coatings, the basics of paints and binders, since these salts are dissolved in water and lower alcohols, but do not dissolve in organic solvents used in coatings formulations, which limits the possibility of their use in ORGANOARSENIC coatings. Moreover, phmg is a moderately toxic substance (3 hazard class), shows the General toxic and irritant effect, the severity of which depends directly on the level and duration of exposure (dissertation Muratova, N. In. for the degree of candidate of medical Sciences "Toxicological-hygienic aspects of action polyhexamethylene guanidine hydrochloride new drug polyguanidine number". -Irkutsk, 1994). In scientific circles up to the present time, there is debate about the toxicity of a specified drug, including its ability to cause toxic hepatitis.

In connection with timerspectrum directions create bactericidal compositions are compositions based on Quaternary ammonium compounds (QAC), for example, alkyldimethylbenzylammonium chloride, wallaba (clathrate Quaternary ammonium compounds with urea), chlorhexidine gluconate and other proven antiseptic. Together is the fact that aqueous or alcoholic solutions of these antiseptics do not show prolonged action. To increase the duration of action of antibacterial drugs in formulations injected nano-sized particles with a diameter of the order of a few nanometers (1 nm = 10-9 m) inorganic sorbent for embedding active components in its structure with the subsequent release during operation or introduction nanobattery metal particles having biocidal properties, or the introduction of chemically modified organic binder.

For example, the known composition for the disinfection of hard surfaces, which is an aqueous colloidal dispersion, which contains inorganic sorbent for embedding active agent nanoparticles of silicon dioxide with a size of 1 to 100 nm, as an active component contains at least one biocide based on Quaternary ammonium, with a ratio of silicon dioxide to Quaternary ammonium 5×10-5:1 to 1.1, and miscible with water and organic solvents, which are used alcohols, diols, glycols, glycol ethers, alkylene glycol ethers and mixtures thereof in an amount of from 0.1 to 5 wt % (US patent No. 2006/0269441, IPC A61L 2/18, 2006). The composition is sprayed on the surface or impregnated non-woven cloths of different fibers. The use of the known SOS is ava allows disinfection by treating the surface with an aqueous solution of a colloidal dispersion, which forms a thin film. However, in the absence of a film-forming substance upon contact with water activity of known composition is lost, and therefore, does not provide an effective prolonged antiseptic. Moreover, it is not intended for surface treatment, no contact with water.

Known composition of the biocidal composition consisting, %: composite, representing a product of the interaction of 10-15 wt.h. cationic water-soluble polymer and 1-5 wt.h. nanoparticles of at least one metal oxide selected from the group comprising zinc oxide, zirconium oxide, cerium oxide, titanium oxide 30-50, the stabilizer of nanoparticles selected from the group comprising alkoxyalkane silane, alkylenediamine, cationic surfactant, a neutral surfactant 0.5 to 5 and water 49,5-69,5 (patent RU №2398804, 2010).

Known composition has insufficient biocidal properties, especially against Staphylococcus aureus, which limits its use in children's and medical institutions.

Known composition film antiseptic protective coatings for inorganic materials and synthetic polymers, consisting of a mixture of polymeric complex of dimethylammoniumchloride containing alkyl group from C8to C16with with the alimera of styrene with maleic anhydride, which was previously subjected to chemical modification to the disclosure of anhydrite cycles with the formation of carboxylate groups, butyral when their ratios, wt.%: antiseptic polymer 25-50; butyral 50-75 (Patent RU №2445980, IPC A61L 101/46, A61L 2/16, 2012).

Known composition provides the possibility of obtaining an antiseptic film coating prolonged action, where as the active component used Quaternary ammonium salt - ketamin AB. The resulting coating has a resistance, i.e., cannot be washed away. However, the manufacture of known composition requires the use of toxic organic solvents, i.e., the operation of coatings containing significant amounts of film-forming, followed by evaporation to the atmosphere of the solvent and the degradation products of polystyrene. Moreover, replacement and removal also requires significant amounts of toxic solvents, which limits the application of known compounds in the hospital, veterinary institutions. This known composition can be used for processing of metals, ceramics, and materials from synthetic polymers and is not intended for treatment of porous surfaces (trowel joints, stucco, concrete and cement surfaces, etc).

Closest to the present invention is a composition for biocidal coatings containing binders based paint material or film-forming agents, biocidal additive action with nanostructured particle size, which is using 0.5-10 wt.% premodification bentonite in the form of montmorillonite with the particle size of 2-500 nm, in which the alkali metal ions in the modification of bentonite solution catamine AB alkali metal ions are replaced by cations [CnH 2n+1N+(CH3) 2CH2C6H5], where n=10-18 and 0.001-0.5 wt.% capsaicin (patent RU №2338765, 2008). As the paint material used organorazbavljaemye styrene, alkyd, epoxy, pentaftalevyh bases or water-emulsion base or film-forming materials - linseed oil.

Known formulations are difficult to prepare, contain expensive capsaicin, which is in contact with the skin may have irritant effect.

The present invention is to expand the Arsenal waterproof antimicrobial agents prolonged action with high efficiency with environmental safety and provides the ability to use for processing preferably porous surfaces in enclosed spaces intended for medical the aid in institutions, residential facilities for the detention and treatment of animals and other locations.

The technical result - ensuring water resistance, anti-microbial coatings prolonged action, ensuring environmental safety and potential use for treatment of porous surfaces.

The problem is solved in that the proposed composition to produce antimicrobial coatings comprising nano-sized particles of inorganic substances, active substance, a binder and a solvent, characterized in that the inorganic substance containing silicon dioxide as the active substance contains a mixture of Quaternary ammonium compounds and chlorhexidine, the solvent contains a mixture of ethyl cellosolve and butylcellosolve, and as the binder contains a mixture of polymethylphenyl siloxane resin and a copolymer of butyl methacrylate and methyl methacrylate in the following ratio of components, wt.%:

chlorhexidine (aqueous 20%)
the copolymer of butyl methacrylate and methyl methacrylate1,70-10,0
resin polymethylphenylsiloxane5,0-20,0
silicon dioxide0,5-3,0
3,0-8,0
Quaternary ammonium compound0,5-3,0
the ethyl cellosolve20,0-50,0
butylcellosolve100

As a powder of silicon dioxide can be used AEROSIL, manufactured on an industrial scale according to GOST 14922-77, such as grades A-150, A-200, A-300 (not modified) or R805, R972 (hydrophobic), which have a particle size from 5 nm to 40 nm (nanoparticles).

As solvents used ethyl cellosolve according to GOST 8313-88 representing monotropy ether of ethylene glycol, and butylcellosolve produced according to TU 6-01-646-84.

As a binder used is a copolymer of butyl methacrylate and methyl methacrylate, manufactured on an industrial scale, for example, under the trade name NeoCryl B-725, and polymethylphenylsiloxane resin, manufactured on an industrial scale, for example on THE 2228-277-05763441-99, also known as Lacquer PMFS. As a mixture of these binders can be used, the mixture is produced on an industrial scale under the trademark Lacquer KO-085 beyond 6-02-753-78.

As an active ingredient use chlorhexidine 1,6-Di- (para-chlorpheniramine)-hexane. Available in the form of BiH is konata (Chlorhexidini bigluconas), -20% aqueous solution. Shown locally and externally as an antiseptic in the form of aqueous or aqueous-alcoholic solutions, including for the treatment of mucosal tissues.

As the active component used Quaternary ammonium compound (QAC) of General formula:

where R, R1, R2, R3- organic substituents:

methyl; benzyl or alkyl With10-C18;

X is chloride or bromide

or the General formula:

where R, R1, R2, R3- organic substituents:

methyl; benzyl or alkyl With10-C18;

X is chloride or bromide;

in the form of clathrate with urea.

As the above HOURS may be used, for example, dialkyldimethylammonium bromide,14-C18dialkyldimethylammonium bromide,10-C12the clathrate with urea, alkylbenzyldimethylammonium chloride, With12-C14alkyltrimethylammonium,12-C14chloride, alkyltrimethylammonium,12-C14bromide or a combination of these or other similar compounds, such as Welcab representing the HOUR-clathrate Quaternary ammonium compounds with urea, produced in industrial scale CJSC "VELT" (Russia), or its analogues, containing H-Villagran, Asenal Liquide, Lactase, MDS-2.

Declare HDMI is the information obtained as follows. About half the stated amount of solvent mixture is mixed with the stated amount of active ingredient, which is used as a mixture of H and chlorhexidine in the presence of a powder of silicon dioxide, which is used as Aerosil. Mixing suspensions are mostly using ultrasonic treatment, which may be implemented, for example, ultrasonic instrument grade USD-125 in normal mode preferably within 15 to 20 minutes at workshop temperature. The second half of the solvent mixture mixed with a binder, the resulting mixture was added into a slurry of silica and subjected to ultrasonic homogenization effects for 5-7 minutes. The resulting composition is used for treatment of walls, ceilings, rubbing seams, etc. surfaces by spraying or by brush application or any other known method. Application of the inventive composition is carried out once a continuous layer on the prepared dry surface at temperatures below +5 C and above +35 C at a relative humidity not exceeding 75%.

The deposition is performed using a standard aerosol container, special spraying equipment according to the passport data and the instructions for their use (consumption rate of 45 g/m2), soft flat brush is or roller (usage rate of 50 g/m 2). When performing work on the application of the proposed structure of the real consumption depends on the qualification of personnel, application methods, equipment, condition and type of surface and other conditions, and may deviate from the norm by 10-50%.

The drying time of the coating depends on the following factors: temperature, relative humidity, ventilation. High humidity, low temperature, poor ventilation slow down the drying process and may hinder the adhesion of the coating to the substrate. It is therefore necessary to provide the most favorable conditions for the coating. By ensuring the necessary conditions, the drying time is 3 hours.

The drying is carried out under natural conditions. At ambient temperature (25±5)°C and relative humidity of 75%. The coating dries quickly, forming a transparent thin film.

After the set time for drying, flushing of the proposed structure in wet processing does not occur.

Full operational properties of the surface coated with the inventive composition, acquires after 3 days.

Control of the formation of the coating carried out visually with natural or artificial daylight diffused light. The floor should be solid, transparent, homogeneous, smooth, without cracks, blisters.

Compare the proposed method with the prototype allows to conclude that the criterion of "novelty."

In science and technology known to use the HOUR and their combinations as a disinfectant to achieve antibacterial (against gram-negative and gram-positive bacteria), fungicidal and virucidal activity. It is also known the use of chlorhexidine as a bactericidal agent. Using a mixture of H and chlorhexidine in the inventive composition allows to increase the antimicrobial activity of a new drug and to provide prolonged action in the processing of solid, preferably porous, surfaces, wood, cement seams, plastered surfaces, etc.

A new technical result can be explained by the fact that by mixing nanoparticles of silicon oxide in terms of ultrasound exposure (continuare), hydrophilic particles of silicon oxide create a stable colloidal system in which particles of silicon dioxide are not susceptible to agglomeration, i.e., each particle becomes available for further interaction with the HOUR and chlorhexidine. Ultrasonic treatment on the mixture of silicon dioxide is a mixture of H with chlorhexidine leads to the fact that during sorption and electrostatic interaction of positively charged particles HOUR with negatively charged nanoparticles of silicon dioxide forms a stable complex, antimicrobial act shall want to make which was higher what activity net HOUR. The activity of the composition obtained by the claimed method, is stored for a long time, because the used binder provides uniform release of the active ingredient, does not block its action, i.e., provides a prolonged effect of the coating formed by drying the composition on the treated surface. Used solvent ensures the stability of the proposed structure to delamination within 12 months, preventing crystallization of the active component, i.e., for a long time retains the original properties of the composition. Moreover, it is claimed mixture of solvents in the specified interval value provides a manifestation of the synergistic effect of the use of mixtures of active ingredients adsorbed on the nanoparticles of silicon dioxide.

The claimed technical result is not obvious from the well-known in science and technology knowledge, i.e., is non-obvious. Therefore, there are grounds for inferring the compliance of the claimed invention, the criterion of "inventive step".

The inventive composition can be manufactured using known in the science and engineering of materials and equipment, i.e., the claimed technical solution meets the criterion of "industrial applicability".

Appl is Amy composition is illustrated by the following examples of specific performance.

Example 1 (invention)

In a container pour half the required quantity of a mixture of ethyl cellosolve and butylcellosolve the required amount of chlorhexidine in the form of a 20% aqueous solution and HOUR, which take Velta, and powder Aerosil a-150, mix with each other under conditions of ultrasonic influence USDP-125 power of 100 W for 15 minutes at workshop temperature, receiving a suspension nanocomposites nanocomposite. In a separate bowl mix the second half of the required quantity of a mixture of ethyl cellosolve and butylcellosolve with the required quantities of the copolymer of butyl methacrylate and methyl methacrylate brand NeoCryl B-725 and polymethylphenylsiloxane resin Varnish pfms. The resulting binder solution added to a suspension of nanocomposites nanocomposite and mix them with each other in terms of ultrasonic influence USDP-125 power of 100 W for 5 minutes at workshop temperature with obtaining the claimed composition. These components take the next time their ratio, wt.%

butylcellosolve
the copolymer of butyl methacrylate and methyl methacrylate1,7
resin polymethylphenylsiloxane16,7
the ethyl cellosolve30
42,3
silicon dioxide1,3
chlorhexidine (aqueous 20%)6,7
Quaternary ammonium compound1,3

Evaluation of the effectiveness of disinfectant antibacterial action of coatings on the basis of the obtained nanocomposites nanocomposite was carried out in relation to the most relevant pathogens of nosocomial infections.

To conduct the study used glass slides coated with disinfectant coating based nanocomposites nanocomposite, as well as solutions containing the inventive composition. The study disinfectant effect was performed using nosocomial multiresistant to antibiotics of strains of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter spp.) by applying the working dilutions of the cultures of these microorganisms on the surface with the appropriate coatings.

Preparation of the working dilutions of the studied crops. From overnight cultures of these microorganisms grown on stubble mesopatamia agar, prepared stock breeding, in which the titration was determined by the concentration of living cells. To determine the working concentration of the Nations did crops 50 μl of each of serial tenfold dilutions of the suspension of microorganisms in Petri dishes with nutrient medium (Mueller-Hinton) and were cultured for 24 hours at 37°C, then counted the number of formed colonies in each Cup. After determining the concentration of microorganisms in stock dilutions were prepared working dilution cultures based education on the surface of the agar in the Petri dish at sowing and 50 ál material 500-1000 colonies.

Study of antibacterial activity of liquid samples was performed by determination of residual infectious activity of test cultures after exposure to solutions containing decreasing concentrations of composites. The results of the evaluation of bactericidal activity are shown in table 1.

As can be seen from the data in table 1, the coatings obtained from the inventive nanocomposites nanocomposite, they have a strong bactericidal effect against the studied strains.

Check biocidal action of the nanocomposites nanocomposite sample was performed in accordance with the requirements of the "R 4.2.2643-10. 3.5. Disinfectology. Methods of laboratory research and testing of disinfectants to assess their efficacy and safety. Guide" (appr. Rospotrebnadzor 01.06.2010). As the test cultures were used: Staphylococcus aureus was ATSS 6538, Escherichia coli was ATSS 25922, Pseudomonas aeruginosa was ATSS 9027, Klebsiella pneumoniae ATCC 43816, Enterobacter agglomerans ATCC 13460, Aeromonas hydrophila ATCC 7966, Shigella sonnei ATCC 11060, Chlamydia trachomatis ATCC VR-885.

Poorly soluble in water sample nanocomposites nanocomposite investigated unesennymi and dried on hard surfaces (glass slides) method prints on sterile and non-sterile agar in Petri dishes at room temperature 25°C and 37°C. Microbial growth was detected after 24 hours.

The study showed that the germination of all samples was observed colonies of microorganisms at a temperature of 37°C, regardless of sterile culture medium directly around the glass with antimicrobial coating. Using diffuse method studied antimicrobial activity of the sample.

To determine the antimicrobial activity of the sample by the method of diffusion in agar with the use of holes in 100 ml of molten and cooled to 60-65°C in nutrient agar medium was brought to 0.5 ml of the diluted suspension standard suspension and poured into Petri dishes and 20 ml. then pour the cups were dried for 30 min and was done at a distance of 28 to 30 mm from the center of the circumference of the Cup three holes with a diameter of 8 mm (special device). The wells were placed prepared solutions of the samples. Microbial growth was assessed by measuring the diameter of zones of no growth of microorganisms in mm the Obtained data are presented in table 2.

As can be seen from table 2, the inventive composition shows satisfactory antimicrobial activity in initial concentration (without dilution).

The duration of antimicrobial activity of the sample is studied at a time four methods disco-diffusion and diffusion in agar with the use of holes in the Petri dish, with Neogen is received, the time of exposure. The data presented in table 3. As can be seen from table 3, insoluble in water nanocomposite of example 1 shows pronounced biocidal properties, antimicrobial properties continue for quite a long time (up to 14 days) in the form of a solid dry coating that mainly distinguishes these samples from known antimicrobial agents (in particular Hours), which lose their antimicrobial activity after drying.

In addition, to determine the duration and effectiveness of the biocidal action of the inventive sample in the form of a coating field trials were carried out. The inventive composition was applied by spraying from a spray on ceramic tile public toilet with the formation of the coating. The swabs were produced (within 5 months, with equal intervals of 1 month) transport environment for crop nutrient medium to determine the germination of microorganisms and using Beketov (HiMedia) for calculating microbial numbers (assuming germination environments Beketov). Data on the duration and effectiveness of the biocidal action is given in table 4.

As a control used a similar surface without processing in the study.

As table 4 shows, field trials showed biocidal action antiseptic coatings of the samples of example 1, which is protected for 4 months for fungi/yeast and more than 5 months for bacteria in the conditions of regular wet cleaning of treated surfaces.

Example 2-7 (invention). The sample was produced analogously to example 1 in a ratio of components, wt.%, specified in table A.

The obtained samples were tested by the methods described in example 1. The properties of the compositions of examples 2-7 match the properties of the sample of example 1.

The compositions according to the invention were tested for processing plastered surfaces, concrete surfaces and cement joints with grout by applying a brush with the consumption of 1 litre of the composition according to example No. 1 of 20 m2surface. On the treated surface is formed colorless hydrophobic film, the plaster does not swell and does not change appearance. Does not change its performance properties of concrete and cement surfaces. Operation conditions - twice daily wet surface covered with disinfectant covering (plaster and cement joints of ceramic tile), humidity of the concrete surface of the basement. Studies have shown that the bactericidal activity of the coating was maintained for at least 3 months.

The compositions according to the invention were tested for treatment of cells and animal stalls, tables for packaging dry food (protein) in the conditions of daily double wet processing. As the test showed, the surface of the inventive composition provides anti-Christ. croboy protection for at least 3 weeks environmentally safe.

The use of the claimed composition allows to obtain a bactericidal coating in the form of varnish, which, in addition to prolonged disinfectant action, provides water, environmental security and the possibility of their use for treatment of porous surfaces.

1. Composition to produce antimicrobial coatings comprising nano-sized particles of inorganic substances, active substance, a binder and a solvent, characterized in that the inorganic substance containing silicon dioxide as the active substance contains a mixture of Quaternary ammonium compounds and chlorhexidine, the solvent contains a mixture of ethyl cellosolve and butylcellosolve, and as the binder contains a mixture of polymethylphenyl siloxane resin and a copolymer of butyl methacrylate and methyl methacrylate in the following ratio of components, wt.%:

the copolymer of butyl methacrylate and methyl methacrylate1,7-10,0
resin polymethylphenylsiloxane5,0-20,0
silicon dioxide0,5-3,0
chlorhexidine (aqueous 20%)3,0-8,0
Quaternary ammonium compound0,5-3,0
the ethyl cellosolve20,0-50,0
butylcellosolverest

2. The composition according to p. 1, characterized in that the Quaternary ammonium compound contains a salt of the General formula:
[RR1N+R2R3]X-, (1)
where R, R1, R2, R3- organic substituents:
methyl; benzyl or alkyl (C10-C18;
X is chloride or bromide.

3. The composition according to p. 1, characterized in that the Quaternary ammonium compound contains a salt of the General formula:
[RR1N+R2R3]X-, (1)
where R, R1, R2, R3- the organization is a mini-deputies:
methyl; benzyl or alkyl (C10-C18;
X is chloride or bromide,
in the form of clathrate with urea.

4. The composition according to p. 1, characterized in that silicon dioxide contains hydrophilic or hydrophobic Aerosil with a particle size of from 5 nm to 40 nm.



 

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2 cl, 1 dwg, 1 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to bio-compatible conjugated polymer nanoparticle, dicarbonyl-lipid compound, compound in form of vesicles, micelles or liposomes, containing multitude of nanoparticles, including said dicarbonyl-lipid compound, method of treating cancer or metastases, biocompatible polymer, as well as to conjugate. Biocompatible conjugated polymer nanoparticle includes main chain of copolymer, with at least one polymer monomer containing two side chains, selected from the group, consisting of carboxylic acid, amide and ester, and sad side chains are separated from each other by 1-1- carbon atoms, oxygen atoms or sulphur atoms, or their any combinations. Said nanoparticle further contains multitude of side chains, covalently bound with said main chain, with said side chains being selected from the group, consisting of monosaccharides, dicarboxylic acids, polyethyleneglycol and their combinations; and multitude of platinum compounds, dissociatedly bound with said main chain. Multiple platinum compounds are connected with said main chain via at least one coordination bond between carbonyl oxygen of carbonyl or amide group of main chain and platinum atom of platinum compound. Said platinum compound is selected from Pt(II) compounds, Pt(IV) compounds and any their combinations. Invention is also aimed at dicarbonyl-lipid compounds, in which platinum compound is dissociatedly bound with dicarbonyl compound. Invention is also aimed at method of treating cancer and metastases. Methods include selection of subject, requiring treatment of cancer or metastases, and introduction to subject of effective amount of nanoparticles, compounds or compositions of the invention.

EFFECT: obtaining biocompatible conjugated polymer nanoparticles for chemotherapeutic platinum-based preparation.

40 cl, 1 tbl, 29 dwg, 12 ex

FIELD: chemistry.

SUBSTANCE: set task is solved by application of final slag, formed in production of ferrovanadium by alumino-silicothermic method as bactericidal material.

EFFECT: extension of raw material resources for bactericidal materials.

1 tbl

FIELD: chemistry.

SUBSTANCE: method includes forming, on a surface, a coating from a dimethylalkylbenzylammonium chloride complex containing a C10-C14 alkyl group or a mixture of C8-C16 alkyl groups with a copolymer of styrene and maleic anhydride, which is subjected to preliminary chemical modification to open anhydride rings to form carboxyl groups, 50-60% of which are neutralised to form carboxylate groups, or a mixture of said complex with polyvinyl butyral, in the following ratio, wt %: antiseptic polymer complex 25-40, polyvinyl butyral 60-75.

EFFECT: full prolonged protection of articles made of aluminium alloy from fouling by microorganisms, which prevents corrosive change of the surface of said alloys.

28 ex, 3 tbl

Water disinfectant // 2533583

FIELD: chemistry.

SUBSTANCE: invention relates to means of purifying and disinfecting different types of water. Described is a disinfectant which contains a first polyhexamethylene guanidine hydrochloride component, a second alkyldimethylbenzylammonium chloride component and water, wherein content of the components in the solution is selected in the following amounts, wt %: first component 7-34.5, second component 1.75-6.9, water - the balance.

EFFECT: disinfection of drinking water.

3 tbl

FIELD: chemistry.

SUBSTANCE: group of invention relates to a synergistic antimicrobial composition which includes a zinc salt of glyphosate and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, and is intended for controlling the level of fungi and algae. The group of inventions also provides a method of inhibiting growth or controlling growth of microorganisms in building material by adding said synergistic antimicrobial composition, a coating composition containing said synergistic antimicrobial composition and a dry film made from said coating composition.

EFFECT: use of the group of inventions increases efficiency of inhibiting growth of microorganisms, provides more precise control of the growth of microorganisms without affecting health and/or the environment.

12 cl, 7 tbl

FIELD: medicine.

SUBSTANCE: tableted antimicrobial composition contains polyhexamethylene guanidine hydrochloride (PHMH) in a combination with at least one ingredient specified in a group: quaternary ammonium compound (QAC), N,N-bis-(3-aminopropyl)dodecylamine and persol, as well as with an alkaline metal iodide and ammonium iodide. The antimicrobial composition has the following ratio of ingredients: PHMH - 10 to 70 wt %; QAC, N,N-bis(3-aminopropyl)dodecylamine and/or persol - 1 to 30 wt %; an alkaline metal iodide and ammonium iodide - 0.1 to 20 wt %.

EFFECT: using the invention provides the fast-acting tableted antimicrobial composition having a wide antimicrobial spectrum and a higher level of biocidal activity.

5 cl, 2 tbl, 2 ex

FIELD: agriculture.

SUBSTANCE: invention relates to the field of poultry industry and is intended for sanation of poultry hatching eggs. The method comprises processing the egg surface with aqueous solution of preparation based on milk whey with lactulose and quaternary ammonium compound trimethyloctadecyl ammonium bromide. As the aqueous solution of the preparation based on milk whey with lactulose and quaternary ammonium compound trimethyloctadecyl ammonium bromide 0.1-0.2% aqueous solution of the preparation is used, taken in equal proportions and diluted with water in a ratio of 1:10. Hatching eggs are processed 2-4 hours prior to their laying for incubation.

EFFECT: use of claimed method enables to carry out effectively sanation of poultry hatching eggs.

1 tbl, 1 ex

FIELD: cosmetology.

SUBSTANCE: agent comprising ethanol, glycerol, Carbopol ultrese and softened water according to the invention comprises aminomethylpropanol, essential oil selected from the group: eucalyptus essential oil, lemon essential oil, peppermint essential oil, anise essential oil, jasmine essential oil with the following ratio of components in g per 100 g of gel: ethanol 65.0-66.0; glycerol 1.0-2.0; Carbopol ultrese 0.16-0.18; aminomethylpropanol 0.06-0.08; essential oil 0.005-0.03; softened water - up to 100.0.

EFFECT: invention has a high antimicrobial activity against pathogenic bacteria, fungi and viruses and provides safety for life and health of people without causing allergy.

4 cl, 4 ex

FIELD: chemistry.

SUBSTANCE: biocidal composition for soaking napkins contains benzethonium chloride, sodium hydroxymethylglycinate, glycerine, decyl polyglucose, niacinamide, liposentol hydro, phenylmethanol and distilled water. Components are used in a defined ratio given in wt %.

EFFECT: invention improves biocidal properties of the napkin soaking composition.

3 tbl, 1 ex

Disinfectant // 2514097

FIELD: chemistry.

SUBSTANCE: invention discloses a disinfectant and can be used in prevention and treatment facilities, at first aid facilities, disinfection facilities, child care centres, public catering facilities, public utilities, transportation, veterinary, agriculture, food industry enterprises and other sectors, as well as for pre-sterilisation cleaning of medical items, including surgical and dental instruments, rigid and flexible endoscopes and other instruments. The disinfectant contains catamine AB, isobornyl acetate, isopropanol, α-pinene, glutaric aldehyde, glycerine, a nonionic surfactant and water in defined ratios.

EFFECT: disinfectant does not cause corrosion in articles made of metal and decomposition of metals and endoscope units; does not cause organic contamination.

3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine, namely to clinical allergology, and may be used for extracorporeal allergen denaturation. That is ensured by treating a surface of objects with an allergen-denaturing composition. The composition contains calcium chloride or calcium acetate and lanthanum chloride or lanthanum nitrate in certain proportions.

EFFECT: combinations of the above metal salts selected in certain proportions provide the effective allergen denaturation ex vivo by a synergistic denaturation action of the given ingredients.

9 cl, 4 tbl

FIELD: chemistry.

SUBSTANCE: method includes forming, on a surface, a coating from a dimethylalkylbenzylammonium chloride complex containing a C10-C14 alkyl group or a mixture of C8-C16 alkyl groups with a copolymer of styrene and maleic anhydride, which is subjected to preliminary chemical modification to open anhydride rings to form carboxyl groups, 50-60% of which are neutralised to form carboxylate groups, or a mixture of said complex with polyvinyl butyral, in the following ratio, wt %: antiseptic polymer complex 25-40, polyvinyl butyral 60-75.

EFFECT: full prolonged protection of articles made of aluminium alloy from fouling by microorganisms, which prevents corrosive change of the surface of said alloys.

28 ex, 3 tbl

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