System and method for quantitative measurement of self-ventilating individual's lung compliance

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. A lung compliance is measured in an individual who is at least partially self-ventilating. The quantitative measurement of the lung compliance can represent an assessment, a measurement and/or a rough measurement. The quantitative measurement of the lung compliance can be suspended over common methods and/or systems for the quantitative measurement of the self-ventilating individual's lung compliance; the lung compliance can be quantitatively measured relatively exactly without the use of a force measurement rope or any other external sensing device, which measures a diaphragm muscle pressure directly; the procedure does not require the individual to monitor the diaphragm muscle pressure manually.

EFFECT: quantitative measurement of the lung compliance can be used as an efficient instrument for the individual's health assessment, including detecting fluid retention associated with acute congestive cardiac failure.

15 cl, 4 dwg

 

[01] the Invention relates to the quantitative determination of the elasticity of the lungs of the subject exercising independent ventilation.

[02] Known systems for the quantitative determination (e.g., measurement, assessment and so on) the elasticity of the lungs of subjects. Such systems include ventilation systems, performed with full mechanical ventilation entities. These systems can be implemented, for example, for subjects who are not capable of self-ventilation.

[03] Quantitative determination of compliance of the lungs of the subject exercising independent ventilation depends in part on the pressure of the muscles of the diaphragm during breathing. Essentially, some systems are made to quantify the elasticity of the lungs in subjects that are not themselves engaged in ventilation, require the implementation of a belt for measuring the force or some other sensor that provides a direct measurement of the pressure of the muscles of the diaphragm. Other systems made with the possibility of quantitative determination of compliance of the lungs in subjects exercising independent ventilation require to prescribe and/or to specify the subject to control the pressure of the muscles of the diaphragm manually. However, typically it requires a subject and/or doctor special maneuver, which is in the case of inaccurate runtime may adversely affect the precision and/or accuracy of the estimation of the elasticity of the lungs.

[04] One aspect of the invention relates to a system made with the possibility of quantitative determination of compliance of the lungs of the subject, which at least partially independently carries out ventilation. In one of the embodiments the system includes a device for maintaining pressure, one or more sensors and one or more processors. Device pressure maintenance is configured to generate a flow of breathable gas under pressure to be delivered into the respiratory tract of the subject, which at least partially independently carries out ventilation. One or more sensors configured to generate one or more output signals, which carry information about one or more parameters of the flow of breathable gas under pressure. One or more processors are functionally associated with the device to maintain pressure and one or more sensors and configured to execution of one or more computer program modules. One or more computer program modules contain the control module, the module pressure and modulus of elasticity. A control module configured to control device is the your pressure maintenance, to adjust the pressure of the flow of breathable gas under pressure during a series of consecutive breaths of the subject. The pressure module is configured to determine the pressure to which the flow of breathable gas under pressure should be adjusted by the control module during the breaths of the subject during a series of consecutive breaths so that the first breath the correct pressure to the first pressure and the second breath closest in time to the first breath, the pressure is adjusted to a second pressure that is different from the first pressure, where the pressure module randomly or pseudo-random determines one or more of (i) the position of the first inhalation and the second breath in a series of breaths, (ii) a first pressure, (iii) the second pressure, or (iv) the pressure difference between the first pressure and the second pressure. The modulus of elasticity is made with the possibility of quantifying lung compliance of a subject based on a difference between the first pressure and the second pressure, and one or more output signals generated by one or more sensors during the first inhalation and the second breath.

[05] Another aspect of the invention relates to a method of quantitative determination of compliance of the lungs of the subject, which at least partially independently performs ve is trazio. In one of the embodiments, the method includes delivery of the flow of breathable gas under pressure in the airway of the subject, which at least partially independently carries out ventilation; generating one or more output signals, which carry information about one or more parameters of the flow of breathable gas under pressure; determining the pressure to which the flow of breathable gas under pressure should be adjusted during a series of consecutive breaths of the subject, including determining a first pressure at the first breath and defining a second pressure for a second breath, the nearest in time to the first breath, so, that one or more of (i) the provisions of the first inhalation and the second breath in a series of breaths, (ii) a first pressure, (iii) a second pressure, or (iv) the differential pressure between the first pressure and the second pressure is determined randomly or pseudo-random; the pressure correction flow of breathable gas under pressure to the designated pressure during a series of consecutive breaths; and quantifying lung compliance of a subject based on a difference between the first pressure and the second pressure, and one or more output signals generated during the first inhalation and the second breath.

[06] Another aspect of the invention relates to the system, made with the possibility of quantitative determination of compliance of the lungs of the subject, which at least partially independently carries out ventilation. In one of the embodiments the system includes a means for delivery of a flow of breathable gas under pressure in the airway of the subject, which at least partially independently carries out ventilation; means for generating one or more output signals, which carry information about one or more parameters of the flow of breathable gas under pressure; means for determining the pressure to which the flow of breathable gas under pressure should be adjusted during a series of consecutive breaths of the subject, including a means for determining a first pressure at the first breath and defining a second pressure for a second breath, nearest in time to the first breath, so that one or more of (i) the provisions of the first inhalation and the second breath in a series of breaths, (ii) a first pressure, (iii) a second pressure, or (iv) the differential pressure between the first pressure and the second pressure is determined randomly or pseudo-random; means to adjust the pressure of the flow of breathable gas under pressure to the designated pressure during a series of consecutive breaths; and a means to quantify the distribution of the elasticity of the lungs of the subject based on the difference between the first pressure and the second pressure, and one or more output signals, generated during the first inhalation and the second breath.

[07] These and other objectives, features and characteristics of the present invention, as well as methods of operation and functions of related elements of structure and combination of parts and cost of manufacture will become more clear upon consideration of the following description and appended claims in relation to the accompanying drawings, which together form part of this description, where the same numbers are positions indicate corresponding parts in the various figures. It should be clearly understood that the drawings serve only the purpose of illustration and description, but not limitation of the invention. In addition, it should be understood that the structural features represented or described herein in any one of the embodiments, can also be used in other variants of implementation. However, it should be clearly understood that the drawings serve only the purpose of illustration and description and are not intended as a definition of the scope of the invention. As used in the description and the claims, the singular number include the plural, unless the context expressly stated otherwise.

[08] In Fig.1 illustrates a system made with the possibility of quantitative determination of compliance of the lungs of the subject, which minicamera partially independently carries out ventilation, one or more variants of the invention.

[09] In Fig.2 illustrates a plot of the pressure of the flow of breathable gas under pressure from time to time in accordance with one or more variants of the invention.

[10] In Fig.3 presents a schematic representation of the circuit ventilation by one or more variants of the invention.

[11] In Fig.4 illustrates a graph of the difference of volumes from time to time during the inhalation in accordance with one or more variants of the invention.

[12] In Fig.1 illustrates a system 10 made with the possibility of quantitative determination of compliance of the lungs of the subject 12, which at least partially independently carries out ventilation. Quantitative determination of compliance of the lung may represent the assessment, measurement and/or an approximate measurement. Quantitative determination of compliance of the lungs through the system 10 can be assembled on standard systems for the quantitative determination of compliance of the lungs of subjects exercising independent ventilation, in which the system 10 is able to quantitatively determine the distensibility of the lung relatively accurately without belt for measuring the force or other external perceiving us the device, which directly measures the pressure of the muscles of the diaphragm. Quantitative determination of compliance of the lung may be an effective tool in assessing the health status of the subject 12, including the detection of fluid retention associated with development of acute congestive heart failure. In one embodiment, the exercise system 10 includes one or more devices 14 pressure maintenance, electronic storage 16, user interface 18, one or more sensors 20, a processor 22 and/or other components.

[13] In one embodiment, the exercise device 14 pressure maintenance is configured to generate a flow of breathable gas under pressure for delivery to the airway of subject 12. The device 14 pressure maintenance may control one or more parameters of the flow of breathable gas under pressure (for example, flow rate, pressure, volume, humidity, temperature, composition and so on) for therapeutic purposes or for other purposes. As a non-limiting example, the device 14 pressure maintenance can be performed by control pressure of the flow of breathable gas under pressure to maintain the pressure in the airway of subject 12. The device 14 pressure maintenance may include the device to maintain a positive pressure, such as, for example, the device described in U.S. patent 6105575, which is included, therefore, as a reference in full.

[14] the Device 14 pressure maintenance can be performed with the opportunity to generate a stream of breathable gas under pressure in accordance with one or more modes. A non-limiting example of such a regime is a Continuous positive airway pressure (CPAP). CPAP was used for many years, and proved its usefulness in promoting regular breathing. Another mode to generate a flow of breathable gas under pressure is a Positive pressure of air during inhalation (IPAP). One example mode IPAP mode is a two-level positive air pressure (BIPAP®). In mode two-level positive air pressure to the patient serves a two-level positive air pressure (HI and LO). Provided by other modes of generation of the flow of breathable gas under pressure. In General, synchronization, HI and LO pressure levels is controlled so that the HI level positive air pressure is delivered to the subject 12 during inhalation, and LO the level of pressure delivered to the subject 12 during exhalation.

[15] the Flow of breathable gas under pressure delivered to the airway of subject 12 via the interface 24 of the subject. The interface 2 of the subject is arranged to flow breathable gas under pressure, generated by the device 14 to maintain the pressure in the airway of subject 12. Essentially, the interface 24 of the subject contains the pipe 26 and the device interface 28. The pipeline carries the flow of breathable gas under pressure in the device interface 28, and the device interface 28 delivers a flow of breathable gas under pressure in the airway of subject 12. Some examples of device interface 28 may include, for example, an endotracheal tube, a nasal cannula, tracheotomies tube, nasal mask, nasal/oral mask, a full-face mask, the mask all over the face or other interface devices that connect the flow of gas from the airway of the subject. The present invention is not limited to these examples, and provides for delivery of a flow of breathable gas under pressure to the subject 12 with the use of any interface of the subject.

[16] In one embodiment, the implementation of the electronic memory 16 contains an electronic storage medium, which electronically stores information. The electronic storage media of electronic storage 16 can include system storage that is provided by a built-in (i.e., essentially non-removable) in the system 10, and/or removable storage that can Rethimno to connect with the system 10, for example, through a port (for example, a USB port, Firewire port, and so on) or the actuator (for example, the drive disks and so on). Electronic storage 16 can include one or more of optically readable storage environments (e.g., optical disks and so on), magnetically readable storage environments (e.g., magnetic tape, magnetic hard drive, floppy disk, and so on) based on the electric charges of the storage medium (e.g., EEPROM, RAM, and so on), the solid-state storage medium (e.g., flash drive and so on), and/or other electronically-readable storage medium. Electronic memory 16 may store software algorithms, information determined by processor 22, the information received through the user interface 18, and/or other information that enables system 10 to function properly. Electronic storage 16 can represent (in whole or in part) a separate component within system 10, or electronic storage 16 can provide (in whole or in part) embedded in one or more other components of system 10 (e.g., device 14, the user interface 18, the processor 22, and so on).

[17] the User interface 18 is configured to provide an interface between system 10 and the subject 12 through which the subject 12 can provide information to the system 10 and to receive information from system 10. This enables data, results, and/or instructions and any other front of the line elements, jointly referred to as "information", to pass between the subject 12 and one or more of the devices 14, the electronic memory 16 and/or processor 22. Examples of interface devices suitable for inclusion in the user interface 18, include a keypad, buttons, switches, a keyboard, knobs, levers, display screen, touch screen, speakers, a microphone, an indicator light, an audible alarm, printer, and/or other interface devices. In one embodiment, the implementation of the user interface 18 includes a number of separate interfaces. In one embodiment, the implementation of the user interface 18 includes at least one interface that is provided by built-in device 14.

[18] it Should be understood that also provided by the present invention, other methods of connection, wired or wireless, such a user interface 18. For example, the present invention provides that the user interface 18 can be embedded in the interface removable drive is provided by means of electronic storage 16. In this example, the information can be downloaded into the system 10 from a removable drive (e.g., smart card, flash disk, removable disk, and so on), which allows the user(s) to adapt the implementation to the system 10. Other exemplary input devices and methods adapted for use with the system 10 via the user interface 18, include as non-limiting examples of the RS-232 port, RF channel, an IR channel, a modem (telephone, cable or other). In short, any method of information exchange with the system 10 provided by the present invention as the user interface 18.

[19] One or more sensors 20 is configured to generate one or more output signals carrying information associated with one or more parameters of the flow of breathable gas under pressure. One or more parameters may include, for example, one or more of flow rate, volume, pressure, composition (for example, the concentration(s) of one or more components), humidity, temperature, acceleration, velocity, acoustic properties, parameter changes, reflecting the breath, and/or other parameters of the gas. The sensors 20 may include one or more sensors that measure these parameters directly (e.g., via connection through a fluid substance with the flow of breathable gas under pressure to the device 14 pressure maintenance or in the interface of the subject 24). The sensors 20 may include one or more sensors that generate output signal is Aly, indirectly associated with one or more parameters of the flow of breathable gas under pressure. For example, one or more sensors 20 can generate an output signal on the basis of a working parameter of the device 14 pressure maintenance (for example, motor current, voltage, speed, and/or other operating parameters) and/or other sensors. Despite the fact that the sensors 20 are depicted in the same position or adjacent to the device 14 to maintain the pressure, it should not be interpreted as limitations. The sensors 20 may include sensors that are located in multiple locations, such as, for example, within the device 14 to maintain the pressure within (or in connection with) the pipeline 26, the inside (or in connection with) the device interface 28 and/or other locations.

[20] the Processor 22 is configured to provide information processing in the system 10. Essentially, the processor 22 may include one or more of a digital processor, an analog processor, a digital circuit designed to process information, an analog circuit designed to process information, a state machine and/or other mechanisms for electronically processing information. Despite the fact that the processor 22 shown in Fig.1 as a single object, this is done only for illustrative purposes, In some implementations, the processor 22 can contain multiple processing units. These processing units can be physically placed inside a device (for example, device 14 pressure maintenance), or processor 22 may represent processing functionality of many devices, working in unison.

[21] As shown in Fig.1, the processor 22 can be performed with execution of one or more computer program modules. One or more computer program modules may include one or more of the module 30 of respiration parameters, module 32 management module 34 of the pressure module 36 compliance and/or other modules. The processor 22 can be performed with the possibility of execution of the modules 30, 32, 34 and/or 36 by software; hardware; firmware; some combination of software, hardware and/or firmware; and/or other mechanisms for configuring processing capabilities in the processor 22.

[22] Should be taken into account that although the modules 30, 32, 34 and 36 shown in Fig.1 together inside a single processing unit, in implementations in which processor 22 includes multiple processing units, one or more modules 30, 32, 34 and/or 36 can be positioned remotely from the other modules. The story, provide the my different following modules 30, 32, 34 and/or 36, shown for illustrative purposes and is not intended to be limiting, as any of the modules 30, 32, 34 and/or 36 may provide more or less functionality than is described. For example, one or more modules 30, 32, 34 and/or 36 can be eliminated, and some or all of their functionality may be provided by other modules of the modules 30, 32, 34 and/or 36. As another example, the processor 22 can be performed with execution of one or more additional modules that may perform some or all of the functionality attributed below to one of the modules 30, 32, 34 and/or 36.

[23] the Module 30 of the respiration parameters configured to determine one or more parameters of the breathing of the subject. One or more respiration parameters determined on the basis of one or more output signals generated by sensors 20. One or more respiration parameters may include, for example, tidal volume, peak flow, flow rate, pressure, composition, synchronization (for example, the beginning and/or end of the breath, the beginning and/or end of the exhalation, and so on), duration (e.g., inhalation, exhalation, one respiratory cycle, and so on), respiration rate, respiratory rate and/or other parameters. In one embodiment, the implementation module of the respiration parameters 30 defines one or more parameters is s breath on the basis of one inhalation and/or exhalation. As a non-limiting example, the module 30 of the respiration parameters may determine at least one parameter of the breathing each breath in a series of consecutive exhalations. At least one parameter of the breathing may include, for example, tidal volume, peak flow and/or other respiration parameters.

[24] the control Module 32 is configured to control device 14 to maintain the pressure to adjust one or more parameters of the flow of breathable gas under pressure. For example, the control module 32 may control the device 14 to maintain the pressure to adjust the flow rate, pressure, volume, humidity, temperature, composition and/or other parameters of the flow of breathable gas under pressure. In one embodiment, the implementation module 32 of the control device 14 pressure maintenance in order to function in mode two-level positive air pressure, where the pressure is increased to the HI level during inspiration and decreased to LO level during exhalation of the subject 12. The control module 32 may determine when to switch the change from HI to LO or Vice versa, based on the detection of the respiratory passages through module 30 respiration parameters.

[25] Module 34 pressure is arranged to determine the pressure(s) to which p is the current breathable gas under pressure should be adjusted by the control module 32. The pressure of the flow of breathable gas under pressure can be determined by module 34 pressure-based regimens (for example, to maintain positive airway pressure) to allow quantitative determination of the elasticity of the lungs and/or for other purposes. The definition of pressure(s) to which the flow of breathable gas under pressure should be adjusted, includes the definition of HI and LO pressure levels for mode two-level positive air pressure.

[26] As further described below, in order to make it possible to quantify the elasticity of the lungs, the pressure of the flow of breathable gas under pressure should be changed between a pair of breaths that are close to each other in time. As used herein, a couple of breaths that are closest in time to each other, may include a couple of breaths that are directly adjacent (i.e., sequentially without intermediate breaths), or a couple of breaths, which is moderately close to each other in time (e.g., within about 2 minutes, within about 1 minute, within about 30 seconds, within about 15 seconds, and so on). To facilitate such determination module 34 of the pressure is made with the possibility of identifying the Oia first pressure, to which the flow of breathable gas under pressure should be adjusted during the first inhalation and the second pressure different from the first pressure), which is the flow of breathable gas under pressure should be adjusted during the second breath, which is the closest in time to the first breath. You should take into account that in some embodiments provide for a quantitative determination of the compliance of the lung may be based on measurements made in two respiratory movements, which are not the closest in time. Although this may degrade the accuracy and/or precision of quantitation (because of the assumptions related to the physiology of the patient and/or respiratory condition during these two respiratory movements), this deterioration may not be detrimental to the suitability of quantitative determination.

[27] In variants of implementation, in which the system 10 operates in a two-level positive air pressure, the control module 32 implements the first pressure as HI pressure for the first breath, LO pressure (defined by module 34 pressure for exhalation(s) between the first inhalation and the second inhalation, and the second pressure as HI pressure for the second breath. In the variants of implementation, in which the system 10 operates in the CPAP mode, the control module 32 is moved between the first pressure and the second pressure in the breathing passage between the first inhalation and exhalation after the first breath, in the time between the first inhalation and the second inhalation, or breathing the transition between exhalation before the second breath and the second breath.

[28] As further described below, in quantifying the elasticity of the lungs through the system 10, the pressure of the muscles of the diaphragm of the subject 12 assume the same for the first inhalation and the second breath. However, in some cases, if one or more of the synchronization transition level(s) of pressure and/or differential pressure to the first pressure and the second pressure perform regular, periodic manner, the subject 12 may subconsciously start to expect this transition. In response to this expectation, the subject 12 may inadvertently adjust respiratory effort (and the pressure of the muscles of the diaphragm between the first inhalation and the second breath. To avoid this effect, the module 34 pressure can determine the pressure at which the flow of breathable gas under pressure should be adjusted by the control module 32 during a series of consecutive respiratory movements, including the first inhalation and the second breath, so that one or more of (i) the clause(s) of the first breath and/or second breath in a series of consecutive dyatel the different movements, (ii) a first pressure, (iii) a second pressure and/or (iv) the difference between the first pressure and the second pressure can be determined randomly or pseudo-random manner.

[29] As used herein, the term "random" refers to the definition of one or more of the above parameters that approximate the properties of random numbers for the purpose of preventing the expectations of the subject 12. This may include schemes in which pseudorandom particular parameter is determined with some frequency and/or frequency, provided that the period in which the option is repeated, large enough to avoid the subconscious expectations of the subject 12.

[30] as an illustration, in Fig.2 shows a graph of pressure as determined by pressure module similar to the module 34 pressure or similar, depending on the length of the series of consecutive respiratory movements. During a series of consecutive respiratory movements, the module 34 pressure determines the pressure of the flow of breathable gas under pressure in accordance with a mode of two-level positive air pressure in which the pressure is reduced to a LO level 38 during exhalations. On the graph shown in Fig.2, there are many pairs of immediately adjacent pairs of breaths that can be considered is the quality of the first and second breaths, described above. These pairs are marked in Fig.2 position number 40. The position and/or synchronization of these pairs breaths, having individual pressure values associated with them, is a random or pseudo-random distribution, designed to prevent the expectation of the subject. Although it is not shown in Fig.2, the above should be taken into account that in addition to determining the position and/or synchronization of the first and/or second breath in a series of consecutive respiratory movements, like randomly and/or pseudo-random depicted in Fig.2, one or more of the pressure(s) at the time of the first breath and/or the second breath, and/or the differential pressure between the first breath and/or second breath, you can define random and/or pseudo-random manner.

[31] Returning to Fig.1, the elasticity module 36 is configured to quantify the elasticity of the lungs of the subject 12 based on the difference between the first pressure and the second pressure, and one or more output signals generated by sensors 20 at the time of the first and second breaths. In one embodiment, the implementation module of elasticity 36 determines the distensibility of the lungs of the subject 12 by removing the pressure of the muscles of the diaphragm from the equations of the input-output modeling of the respiratory system of the subject 12 during lane is on breath and the second breath.

[32] In one embodiment, the implementation of quantitative determination of compliance of the lungs by means of the elasticity module 36 implements a single-camera light and the scheme of ventilation is shown in Fig.3. In Fig.3,Pdis the pressure in the device (for example, the pressure of the flow of breathable gas under pressure generated by the device 14 pressure maintenance),Rrepresents the resistance of the respiratory system of the subject,Palvis the alveolar pressure, C is the compliance,Pmusis the pressure of the muscles of the diaphragm, andQprepresents a stream of the subject. In this model, suppose that the resistance of the exhalation port (for example, the exhalation port on the device interface 28 of Fig.1) greatly exceeds the resistance of the hose (e.g., pipeline 26 in Fig.1). Consequently, the pressure inside of the subject is approximately equal to the pressure in the device. Thus, pressure of the subject represented in the form of a pressure device in the circuit shown in Fig.3. In addition, suppose that the flow of patient and patient volume can be estimated by using the difference between the total volume flow of the system and the estimated (or measured) peak flow.

[33] Should be taken into account that the implementation of the model single-chamber light in the description definition wide-angle is the elasticity of the lungs should not be interpreted as limitations. Elimination of the pressure of the muscles of the diaphragm from the equations modeling the function of the respiratory system of a subject, does not depend on this model, but is used in this document, since it requires less computation than more complex models, and simplifies the explanation.

[34] the transfer Function in s-domain, linking the flow of the patient with a pressure device and a diaphragm subject to the scheme in Fig.3, sets the expression:

where

[35] Additionally, patient volume specifies the equation:

[36] Thus, the transfer function relates the pressure to the volume of the patient, sets the equation:

where the answer toPmusspecifies the equation:

and where the external response specifies the expression:

[37] Now, ifPd(s)is the pressure of the flow of breathable gas under pressure generated by the device to maintain pressure, and the pressure during inspiration varies between the first inhalation and the second inhalation, which is the closest in time (e.g., directly adjacent), then equation (4) can be written for the first inhalation and the second breath in the following form:

where subscripts 1 and sootvetstvuut the first inhalation and the second breath, respectively.

[38] AsPmusnot known, it is also not known part of the overall response that is associated with the internal response. However, if you make the assumption thatPmusis relatively constant between the first inhalation and the second breath (because the first and second breaths are the closest in time), thenPmus1(s)can be taken equal toPmus2(s).

[39] Taking the difference between the surround responses in equations (5) and (6) and using the assumption thatPmus1(s)equal toPmus2(s)unknown internal response can be eliminated to obtain the following combination of equations (7) and (8):

where ΔV(s)is the difference betweenV1(s)andV2(s)and where ΔPd(s)is the difference betweenPd1(s)andPd2(s).

[40] Since the known pressures and volumes for two breaths (and/or snapshot difference between them), any of many known methods for numerical evaluation can be used to determine the resistance R and the elasticity C. as a non-limiting example, you can implement the method of least square error.

[41] Returning to Fig.1, the elasticity module 36 can be quantitatively to determine the distensibility of the lungs on the basis of the parameter(s) respiration, determined who's through module 30 respiration parameters (which determine output signals, generated by sensors 20), the known value(s) of the first pressure, the second pressure and/or difference between the first pressure and the second pressure in the manner described above. Then this quantification can be implemented for one or more of the many different uses and/or many different contexts. For example, quantitative determination of compliance of the lungs can be implemented for preventive diagnosis of congestive heart failure to prescribe treatment, and/or for other purposes.

[42] Although the invention is described in detail for purposes of illustration based on what is presently considered the most practical and preferred options for implementation, it should be understood that such details are used solely for this purpose and that the invention is not limited to the disclosed variants of implementation, but on the contrary is intended to cover modifications and equivalent arrangement included in the nature and scope defined by the attached claims. For example, it should be understood that the present invention assumes that one or more signs on any variant of the implementation can be combined with one or more features in another variant implementation, to the extent possible.

1. The system can be fixed is with the possibility of quantitative determination of compliance of the lungs of the subject, which at least partially implements an independent ventilation system contains:
device pressure maintenance, configured to generate a flow of breathable gas under pressure to be delivered into the respiratory tract of the subject, which at least partially independently carries out ventilation;
one or more sensors configured to generate one or more output signals, which carry information about one or more parameters of the flow of breathable gas under pressure; and
one or more processors that are functionally associated with the device to maintain pressure and one or more sensors, one or more processors to perform ability to perform one or more computer program modules, the one or more computer program modules contain:
a control module configured to control the device to maintain pressure to adjust the pressure of the flow of breathable gas under pressure during a series of consecutive breaths of the subject;
the pressure module, configured to determine the pressure to which the flow of breathable gas under pressure should be adjusted by the control module during breaths sub the KTA during a series of consecutive breaths so, that first breath the correct pressure to the first pressure and the second breath closest in time to the first breath, the pressure is adjusted to a second pressure that is different from the first pressure, where the pressure module randomly or pseudo-random determines one or more of (i) the provisions of the first inhalation and the second breath in a series of breaths, (ii) a first pressure, (iii) a second pressure, or (iv) the differential pressure between the first pressure and the second pressure;
the modulus of elasticity, made with the possibility of quantitative determination of compliance of the lungs of the subject based on the difference between the first pressure and the second pressure, and one or more output signals generated by one or more sensors during the first inhalation and the second breath.

2. The system under item 1, in which the first pressure and the second pressure is fixed and where the pressure module is configured to determine the pressure to which the flow of breathable gas under pressure should be adjusted by the control module during the breaths of the subject during a series of consecutive breaths so that each breath in a series of consecutive breaths pressure is determined by pressure module or equal to the first pressure or the second pressure.

3. The system under item 1, in which the pressure module also performed with the who what and is very useful for determining pressure, to which the flow of breathable gas under pressure should be adjusted by the control module during the exhalations of the subject between a series of consecutive breaths, lower than the first pressure and lower than the second pressure.

4. The system under item 1, in which one of the modules also includes a module of respiration parameters, configured to determine, based on one or more output signals to one or more sensors, one or more parameters of the breathing of the subject during a series of consecutive breaths, and where the modulus of elasticity is made with the possibility of quantifying lung compliance of a subject based on a difference between the first pressure and the second pressure and one or more respiration parameters defined via the module parameters of respiration during the first inhalation and the second breath.

5. The system under item 4, in which one or more respiration parameters, defined by a module of respiration parameters, which are implemented by means of the modulus of elasticity for the quantitative determination of compliance of the lungs of the subject, contain tidal volume.

6. The method of quantitative determination of compliance of the lungs of the subject, which at least partially independently carries out ventilation, the method comprises:
delivery flow suitable for d is Hania gas under pressure in the airway of the subject, which at least partially independently carries out ventilation;
generating one or more output signals, which carry information about one or more parameters of the flow of breathable gas under pressure;
the definition of pressure, to which the flow of breathable gas under pressure should be adjusted during a series of consecutive breaths of the subject, including determining a first pressure at the first breath and defining a second pressure for a second breath, the nearest in time to the first breath, so that one or more of (i) the provisions of the first inhalation and the second breath in a series of breaths, (ii) a first pressure, (iii) a second pressure, or (iv) the differential pressure between the first pressure and the second pressure is determined randomly or pseudo-random;
the pressure correction flow of breathable gas under pressure to determine the pressure during a series of consecutive breaths; and
quantitative determination of compliance of the lungs of the subject based on the difference between the first pressure and the second pressure, and one or more output signals generated during the first inhalation and the second breath.

7. The method according to p. 6, in which is fixed the first pressure and the second pressure, and where the determination of the pressures to which the flow of breathable gas under pressure should the journalist is to chirawat during a series of consecutive breaths of the subject, includes selecting between the first pressure and the second pressure for each breath in a series of consecutive breaths.

8. The method according to p. 6, which also contains a correction to the pressure of the flow of breathable gas under pressure during exhalation of the subject between a series of consecutive breaths to pressure, which is lower than the first pressure and lower than the second pressure.

9. The method according to p. 6, which also contains a definition based on one or more output signals, one or more parameters of the breathing of the subject during a series of consecutive breaths, and where quantitative determination of compliance of the lungs of the subject based on the difference between the first pressure and the second pressure, and one or more output signals generated during the first inhalation and the second breath, contains quantitative determination of compliance of the lungs of the subject based on the difference between the first pressure and the second pressure and one or more respiration parameters determined during the first inhalation and the second breath.

10. The method according to p. 9, in which one or more respiration parameters contain tidal volume.

11. The system is made with the possibility of quantitative determination of compliance of the lungs of the subject, which at least partially implements an independent ventilation system contains:
funds is to deliver the flow of breathable gas under pressure in the airway of the subject, which at least partially independently carries out ventilation;
means for generating one or more output signals, which carry information about one or more parameters of the flow of breathable gas under pressure;
means for determining the pressure to which the flow of breathable gas under pressure should be adjusted during a series of consecutive breaths of the subject, including means for determining a first pressure at the first breath and defining a second pressure for a second breath, the nearest in time to the first breath, so that one or more of (i) the provisions of the first inhalation and the second breath in a series of breaths, (i) a first pressure, (iii) a second pressure, or (iv) the differential pressure between the first pressure and the second pressure is determined randomly or pseudo-random;
means for correcting the pressure of the flow of breathable gas under pressure to the designated pressure during a series of consecutive breaths; and
means for quantifying lung compliance of a subject based on a difference between the first pressure and the second pressure, and one or more output signals generated during the first inhalation and the second breath.

12. System on p. 11, in which is fixed the first pressure and the second pressure, and where the means for determining Yes the lines, to which the flow of breathable gas under pressure should be adjusted during a series of consecutive breaths of the subject, includes a means for selecting between the first pressure and the second pressure for each breath in a series of consecutive breaths.

13. System on p. 11, which also includes means to adjust the pressure of the flow of breathable gas under pressure during exhalation of the subject between a series of consecutive breaths to pressure that is lower than the first pressure and lower than the second pressure.

14. System on p. 11, which also contains a means for determining, based on one or more output signals, one or more parameters of the breathing of the subject during a series of consecutive breaths, and where the means for quantifying lung compliance of a subject based on a difference between the first pressure and the second pressure, and one or more output signals generated during the first inhalation and the second breath, quantitatively determines the distensibility of the lungs of the subject based on the difference between the first pressure and the second pressure and one or more respiration parameters determined during the first inhalation and the second breath.

15. System on p. 14, in which one or more respiration parameters contain tidal volume.



 

Same patents:

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. A lung compliance is measured in an individual who is at least partially self-ventilating. The quantitative measurement of the lung compliance can represent an assessment, a measurement and/or a rough measurement. The quantitative measurement of the lung compliance can be suspended over common methods and/or systems for the quantitative measurement of the self-ventilating individual's lung compliance; the lung compliance can be quantitatively measured relatively exactly without the use of a force measurement rope or any other external sensing device, which measures a diaphragm muscle pressure directly; the procedure does not require the individual to monitor the diaphragm muscle pressure manually.

EFFECT: quantitative measurement of the lung compliance can be used as an efficient instrument for the individual's health assessment, including detecting fluid retention associated with acute congestive cardiac failure.

15 cl, 5 dwg

FIELD: medicine.

SUBSTANCE: invention relates to sports medicine. Method includes carrying out interval hypoxic training with breathing gas mixture with simultaneous influence on central nervous system by pulse electric current. Before interval hypoxic training additionally realised is introduction of neuropeptide Semax in dose of two drops in each nasal passage. Interval hypoxic training is carried out at least four times by breathing gas mixture, which contains 9.5% of oxygen. Influence by electric current is realised with pulse duration 0.25-0.28 ms, current power 0.9 mA and frequency of pulses 1250 Hz for 60 minutes.

EFFECT: method ensures acceleration of organism readjustment to functioning in extreme conditions of influence, ensures increase of work efficiency.

1 tbl

FIELD: medicine.

SUBSTANCE: system comprises a breathing device, which is configured to generate a pressurized breathing gas flow into the airway, and respiratory indicators, which cause an individual breath so that the respiratory volume exceeds or is equal to the target respiratory volume. The respiratory indicators comprise the pressurized flow pressure fluctuation. Sensors form one or more output signals transmitting the information related to exhaled gas parameters, which are related to the respiratory volume. A processor is configured to provides modules. The parameter module is configured to determine a respiratory parameter of one or more output signals formed by one or more sensors. The respiratory parameter is either the respiratory volume, or the inhaled gas parameter related to the respiratory volume. The module of congruence is configured to compare the respiratory volume to a threshold, which corresponds to the target respiratory volume. The control module is configured to control the respiratory device to control the respiratory indicators presented for the individual by comparing the respiratory parameters and the threshold by the module of congruence. What is disclosed is a method for respiratory volume control.

EFFECT: providing the relation of the actual and target respiratory volumes.

6 cl, 4 dwg

FIELD: medicine.

SUBSTANCE: group of inventions relates to medical equipment. System for supporting positive pressure in patient's respiratory ways, when patient is breathing, contains respiratory device, made with possibility of controlling gas mixture flow between surrounding atmosphere and, at least, one external orifice of patient's respiratory ways. Respiratory device has first resistance to flow of gas mixture, flowing from surrounding atmosphere into patient's respiratory ways through respiratory device, and second resistance to flow of gas mixture, flowing from patient's respiratory ways into surrounding atmosphere through respiratory device. First resistance is less than second resistance, so that during inhalation gas mixture flows from surrounding atmosphere into patient's respiratory ways through respiratory device without delay. During exhalation second resistance of respiratory device to gas mixture, flowing from patient's respiratory ways into surrounding atmosphere, increases pressure inside patient's respiratory ways. Increased pressure supports patient's respiratory ways. Pressure generator is made with possibility to form flow of compressed respiratory mixture and providing additional support of patient's respiratory ways and is connected with case of respiratory device through contour, which gas mixture channel forms between respiratory device and pressure generator, by which flow of compressed respiratory mixture is supplied from pressure generator into patient's respiratory ways through respiratory device. First resistance constitutes less than approximately 0.025 cm of H2O with flow consumption 30 l/min. Second version of system, which is different in constructive implementation, is disclosed.

EFFECT: providing treatment of sleeping disorders due to creation of resistance to exhalation.

6 cl, 10 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used in treating the patients with respiratory impairments. A breathing support device comprises a first flow generator an output of which is connected to a patient's breathing system, and a control unit a first input of which is connected to the breathing system, and first and second outputs - to the first flow generator and the breathing system, respectively. The invention provides establishing a second flow generator, a probe inserted into the patient's gastrointestinal tract, a flow sensor and a pressure sensor. The second flow generator connected to the probe inserted into the patient's gastrointestinal tract at an input of which the flow sensor and the pressure sensor are mounted, respectively connected to third and fourth outputs of the control unit a fourth output of which is connected to a pulse oximeter, is connected to the third output of the control unit. The control unit is configured to start a procedure of extrapulmonary administration of oxygen, to determine pressure inside the gastrointestinal tract and controlled reduction of a volumetric flow rate.

EFFECT: enhancing by providing the additional extrapulmonary administration of oxygen into patient's body through the gastrointestinal tract.

1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to anaesthesiology and resuscitation, and can be used in intensive care patients suffering from ventilator-associated pneumonia, or where there is a high risk of development thereof. Stabilising haemodynamics is followed by 8 turns of a patient's body a day. The cycle is started from 08-00: 3 hours on his/her back, 2 hours on his/her side, 2 hours on the other side, 3 hours on his/her back, 6 hours on his/her stomach, 4 hours on his/her back, 2 hours on his/her side, 2 hours on his/her side. The patient's centre of gravity is changed every 2 hours with the patient lying on his/her stomach and back. Propofol is infused at 2-3 mg/kg/hour 20 minutes before the patient is turned on his/her stomach and continued until the patient's position is changed again. A nitroglycerin infusion is started 5 minutes after the patient is turned on his/her back in a dose of 0.5-1.0 mcg/kg/min and continues for 5 hours. An antibacterial preparation is intermittently or microfluid single administered 10 min after the patient is turned on the stomach; observing other rate of administration of the antibacterial preparation, one of the administrations is performed 10 minutes after the patient is turned on the stomach.

EFFECT: method provides effective treatment and/or preventing of ventilator-associated pneumonia by exposing to a gravity factor of regional non-uniform ventilation and pulmonary perfusion, and an excessive hypoxic vasoconstriction.

2 cl, 4 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine. An electric drive device contains a pump, which contains a rigid cylinder, a piston and, at least, one valve, an electric engine with accurate position control, which has working connection with the said piston for the movement of the said piston in the said cylinder, and a controller, made with a possibility of controlling the electric engine to control the piston position in the cylinder, and in this way to control the respiratory volume of gas, supplied into a patient; and the pressure of gas, supplied in the patient. An apparatus of artificial lung ventilation for supply of gas in the patient and a device for artificial lung ventilation are disclosed.

EFFECT: provision of accurate positioning.

58 cl, 11 dwg

FIELD: medicine.

SUBSTANCE: apparatus comprises indicators, an oxygen input connected through a dropping reducer to a breathing valve, an atmospheric input connected to a bactericide filter, an air-oxygen mixture and a flow-control device attached, a flow metre, a safety valve, a pressure relief branch and a tee-joint with an attached pressure sensor and an 'Inhalation' nozzle. The apparatus is additionally provided with an in-built air pump an input of which is pneumatically connected to the air-oxygen mixture provided with an oxygen concentration controller in the gas mixture, and an output - to a pulsation damper connected to the flow-control device and a back-flow adjusting valve. The air pump is electrically connected to an external power source. The safety valve is provided with a pressure level adjuster.

EFFECT: higher patient's safety, enhancing the apparatus.

5 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: simulator comprises a single-seat decompression chamber having a bell-shaped vertical chamber. Decompression chamber walls are made from nylon and have a transparent window, sleeve unions for connecting gas mixture and air tube fitting unions, as well as for connecting respiratory gas mixture heating and pressure control units and connected to a decompression chamber control unit outside the decompression chamber. The heating and pressure control units are placed inside the decompression chamber. The simulator comprises high-pressure cylinders comprising hypoxic and hyperoxic oxygen-helium gas mixture, sleeve unions for connecting tube fitting connected to supply units outside the decompression chamber. The decompression chamber comprises a patient's armchair with an adjustable seat back angle, a heart rate (HR) and arterial blood oxyhemoglobin (SpO2) control system and gas mixture supply system.

EFFECT: designing the mobile system ensuring the cyclic hypoxia and hyperoxia reproduction in the hyperbaric environment using no additional systems and special facilities.

4 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: child is examined to study the external dento-facial visualised structures: an upper lip, an intermaxillary bone, an osteochondral segment of the nose. If observing a right-sided complete and partial cleft lip with non-displaced intermaxillary bone, or a two-sided partial cleft lip with non-displaced intermaxillary bone, or atypical cleft face with undeformed osteochondral segment of the nose, tracheal intubation is performed using an endotracheal tube according to the intubation record. If observing two-sided complete cleft lip, or atypical cleft face with deformed osteochondral segment of the nose, or displaced intermaxillary bone with any cleft type, or left-sided cleft, a laryngeal mask is placed.

EFFECT: substantial reduction of time and quantity of intubation attempts ensured by optimising an approach to choosing the anaesthetic support in the children with the given pathologies caused by reporting the classification of congenital orofacial clefts.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. A lung compliance is measured in an individual who is at least partially self-ventilating. The quantitative measurement of the lung compliance can represent an assessment, a measurement and/or a rough measurement. The quantitative measurement of the lung compliance can be suspended over common methods and/or systems for the quantitative measurement of the self-ventilating individual's lung compliance; the lung compliance can be quantitatively measured relatively exactly without the use of a force measurement rope or any other external sensing device, which measures a diaphragm muscle pressure directly; the procedure does not require the individual to monitor the diaphragm muscle pressure manually.

EFFECT: quantitative measurement of the lung compliance can be used as an efficient instrument for the individual's health assessment, including detecting fluid retention associated with acute congestive cardiac failure.

15 cl, 5 dwg

FIELD: medicine.

SUBSTANCE: technique consists in analysing the exhaled air composition. Cancer is diagnosed if the exhaled air contains cyclohexyl isothiocyanate. Another version of the technique also relates to analysing the exhaled air composition. That involves using a mass-spectrometry procedure preceded by gas chromatographic separation. If observing a substance, a chromatographic peak of which characterises the chromatographic mobility specific for cyclohexyl isothiocyanate, lung cancer is also diagnosed.

EFFECT: techniques provide the reliable diagnosing whatever location, degree and form of cancer are observed that makes it possible to use the non-invasive diagnostic technique for lung cancer as a part of screening examination.

2 cl, 2 tbl, 9 ex, 1 dwg

FIELD: medicine.

SUBSTANCE: group of inventions refers to medical equipment. An individual's pulmonary congestion control system comprises a pressurising system configured to generate a pressurised breathing gas flow to be supplied to the individual's airway depending on a therapeutic routine used to control the pressurised flow parameters; a user's interface configured to provide a user's interaction; processors configured to execute a number of computer program modules. A parameter module is configured to receive output signals from one or more sensors configured to control the inhaled gas parameters. The sensor comprises a pressure probe, a flow meter or a carbonometer. The output signals contain the inhaled gas information. The parameter module is configured to determine the individual's respiration parameters from the received output signals and to withdraw the therapeutic routine to make it possible to determine one or more individual's respiratory parameters according to the pre-set test mode. A congestion control module is configured to identify a pulmonary congestion case in the individual by reference to the respiratory parameters. A notification module is configured to control the user's interface to provide the user with a notification of the pulmonary congestion case. There are disclosed a pulmonary congestion control method and a version of a pulmonary congestion control device.

EFFECT: inventions enable the non-invasive pulmonary congestion control.

15 cl, 6 dwg

FIELD: veterinary medicine.

SUBSTANCE: upon detection of an increased level of activity of the horse a therapeutic signal is generated to enforce at least one muscle involved in the shift of the laryngeal anatomical structure with respect to the upper airway of the horse. The therapeutic signal is given to the upper airways tissue for maintaining unobstructed airflow. At that the pacemaker is used in the form of a processor made with the ability to generate the therapeutic signal based on the said detected increased level of activity to enforce the muscle involved in the shift of laryngeal anatomical structure with respect to the upper airway of the horse.

EFFECT: invention enables to improve the efficiency of treatment which is achieved by the stimulation of the upper airway muscles synchronously with the periods of the respiratory cycles of the horse and by functioning of the stimulating system only during an increased physical activity.

20 cl, 6 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: peak volume velocity of forced expiration (VVpeak, l/sec) is determined at 29-36 weeks of pregnancy in patients with mild bronchial asthma (BA) in the attack-free period by the use of spirography. Regional lung rheography is used to determine a respiratory volume of the lower right lung (RVr, Ohm). That is followed by the prediction of the clinical course of bronchial asthma for one year after the child birth by a discriminant equation: D= -5.999×VVpeak-7.491×RVr, wherein D is the discriminant function, a threshold of which is -48.39. If D is -48.39 or more, the controlled clinical course of bronchial asthma is predicted, and if D is less than -48.39, the uncontrolled clinical course of bronchial asthma is predicted.

EFFECT: well-timed complex of measures aiming at preventing the aggravations of bronchial asthma in the given category of patients by the acute prediction of the clinical course of bronchial asthma.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to devices for the remote non-contact monitoring of the parameters of living body vital activity. The device for the remote non-contact monitoring of the parameters of living body vital activity comprises: at least one measuring unit, at least one control and data processing unit, and at least one interface series connected. The measuring unit comprises at least one radio transmitting unit, and at least one radio receiving unit. The control and data processing unit is configured to form driving pulses for each of the radio transmitting and radio receiving units randomly time-delayed in relation to each other and additionally designed to form driving pulses for each of the radio transmitting and radio receiving units of the random length in relation to each other. Each of the radio transmitting units and/or each of the radio receiving units being the components of the measuring unit is independent on each other.

EFFECT: higher measuring accuracy and reliability.

20 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: 1-second forced expiratory volume is determined by spirography for the purpose of a surgical intervention in the patients suffering from pancreatic diseases complicated with tracheal compression. If the measured volume is from 35% to 54%, an urgent surgery is performed. If the 1-second forced expiratory volume is less than 35%, an emergent surgery is performed.

EFFECT: method enables determining the surgery date with the greatest accuracy in the patients requiring the emergent surgery that in its turn provides the more adequate pre-operative preparation and the improved outcome of surgical management.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: clinical findings are assessed, and laboratory diagnostics is performed. An index ŷ of probability of the bronchopulmonary pathology is additionally calculated by formula: y^=exp(-5.32+0.77x1+0.95x2+1.07x3+1.55x4+2.56x5+0.75x6+0.6x7/(1+exp((-5.32+0.77x1+0.95x2+1.07x3+1.55x4+2.56x5+0.75x6+0.6x7)), wherein y^ is the probability of the bronchopulmonary pathology, x1 is a gestational age: mature - 0, pre-mature - 1; x2 is the length of oxygen therapy more than 336 hours (14 days) - 1, less - 0; x3 is the length of stringent parameters of artificial pulmonary ventilation more than 144 hours (6 days) - 1, less - 0; x4 is the length of stringent parameters of artificial pulmonary ventilation at peak inspiratory pressure more than 72 hours (3 days) - 1, less - 0; x5 is the presence of the burdened hereditary bronchopulmonary system: no - 0, yes - 1; x6 is a degree of connective tissue dysplasia: mild - 0, moderate and severe - 1; x7 is the presence of complications (pneumothorax, atelectasis, pneumonia): no - 0, yes - 1, and if the index of the probability of the bronchopulmonary pathology y^ >0.5 the bronchopulmonary pathology is predicted.

EFFECT: method enables the high-reliability prediction of the bronchopulmonary pathology in the ventilated children in the neonatal period.

1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to pulmonology, and can be used for the acoustic diagnosis of individual's pulmonary focal lesions. That is ensured by recording respiratory murmurs of the chest surface in classical auscultation areas. Inhalation respiratory murmurs are recorded in the A mode. Their spectra are calculated. The acoustic parameters are measured. Spectral background values are subtracted from the spectral inhalation murmurs. That is followed by determining lower and upper frequencies for the difference spectrum accompanied by an analysed spectrum increase over the background by 10 dB. An upper cut-off frequency of -3 dB is measured by a lower frequency of a 10dB excess of the analysed spectrum over the background. The upper cut-off frequency of -20 dB from the average noise amplitude between the lower frequency of the 10 dB excess of the analysed spectrum over the background and the spectral cut-off frequency of -3 dB. The local pathological areas are diagnosed by comparing the acoustic parameters of the cut-off frequency of -3 dB and -20 dB to the respective threshold values in each analysis point.

EFFECT: technique provides more effective diagnosis of the pulmonary focal lesions and enables intra-roentgen monitoring of the pulmonary focal mass lesions.

1 ex, 2 tbl, 1 dwg

FIELD: medicine.

SUBSTANCE: at first the Kerdo index and a respective pulmonary oxygen consumption model at various physical activity levels, including no-load (lying, after 8-hour sleep, on an empty stomach) is constructed. Thereafter, an individual's energy consumption rate is derived from the measured Kerdo index, exhaled carbon dioxide and values obtained at the stage of the model construction. According to the other version, the Kerdo index and the respective pulmonary oxygen consumption model at various physical activity levels, including no-load (lying, after 8-hour sleep, on an empty stomach) is constructed. Thereafter, the individual's energy consumption rate is derived from the measured Kerdo index, exhaled carbon dioxide and daily nitrogen clearance in the form of carbamide.

EFFECT: group of inventions enables determining an individual's rest catabolism level on the basis of the measured graduated increasing cycloergometric load, the Kerdo index and carbonometry in testing; taking into account protein oxidation enables additional determination of carbamide excretion over the analysed day.

4 cl, 2 ex, 1 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves connecting patient to device via bite-board. The patient makes expiration via tube connected to inlet valve of respiratory sack. The expired air is accumulated in the respiratory sack in the amount of equal to the respiratory sack volume. Timer is set for 15 min after being filled. Microcompressor pumps the air expired by the patient via tube filled with silicagel at constant flow rate. The patient goes on filling the respiratory sack with expired air while the microcompressor is operating. After the timer expires, 0.5-1.0 ml of humidity is obtained from the expired air adsorbed on silicagel. Single-use tube containing silicagel is soldered and kept in frost chamber until its biochemical examination is carried out. The device has airtight respiratory sack having inlet and outlet valves. The inlet valve is connected to tube provided with bite-board. The outlet valve is connected to tube containing silicagel layer.

EFFECT: humidity sampling independence of patient state.

2 cl, 1 dwg

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