Method of producing polymer complex having antiseptic properties and antiseptic coating based thereon

FIELD: chemistry.

SUBSTANCE: method includes forming, on a surface, a coating from a dimethylalkylbenzylammonium chloride complex containing a C10-C14 alkyl group or a mixture of C8-C16 alkyl groups with a copolymer of styrene and maleic anhydride, which is subjected to preliminary chemical modification to open anhydride rings to form carboxyl groups, 50-60% of which are neutralised to form carboxylate groups, or a mixture of said complex with polyvinyl butyral, in the following ratio, wt %: antiseptic polymer complex 25-40, polyvinyl butyral 60-75.

EFFECT: full prolonged protection of articles made of aluminium alloy from fouling by microorganisms, which prevents corrosive change of the surface of said alloys.

28 ex, 3 tbl

 

The present invention relates to the production technology of polymer coating to protect the aluminum from microbial growth on their surface.

Most effectively the invention can be used in objects, which imposed requirements on the level of microbial load.

The relevance of the developed method is to use alloys of aluminum in the presence of people on the objects, areas, etc. where regulated microbial load, and hermozamente premises, which do not permit the growth of microorganisms on the surface of materials from aluminum alloys even in conditions of high humidity.

Known polyelectrolyte complexes catamine AB with polymers containing acid groups, in which katamin AB is associated with a chain of the macromolecule ionic bond. In particular, the complex catamine AB with a copolymer of N-vinylpyrrolidone with crotonic acid [USSR author's certificate No. 1607359 A1, class 6 C08F 226/10, 1995]. This polymer complex containing Quaternary ammonium groups with a long-chain alkyl substituent in as counterion, has a strong antiseptic effect. Similar action has complex catamine AB with carboxymethylcellulose proposed [RF patent №2146136 C1, CL 7 AC 31/14, 200,] as an antiseptic. However, both of the above complex are water-soluble and cannot be used as a film antiseptic protective coating.

The known method [patent WO 2007/024973 A1, cl. A01N 25/32], where as antimicrobial coatings are used polymethacrylates, polyurethanes, derivatives polyvinylidenechloride and other polymers containing covalently associated with the chain of the macromolecule a Quaternary ammonium group with a long-chain substituent. These polymers are not soluble in water, but soluble in alcohols, from solutions which can be formed by coating. However, in the monograph [Afinogenov, E., Panarin E. F. Antimicrobial polymers, St. Petersburg, Hippocrates, 1993, 264 S.] and the review [Panarin E. F., Kopeikin Century Century high-Molecular compounds. Series C, 2002, T. 44, No. 12, S. 2340-2351] for numerous examples show that the antimicrobial properties of polymers containing covalently linked Quaternary ammonium group, below antimicrobial properties similar model of low molecular weight Quaternary ammonium compounds and polyelectrolyte complexes of ionic surfactants, in which the Quaternary ammonium groups with a long-chain alkyl Deputy linked to the main chain of the polymer ionic bond.

The closest in technical essence and the achieved result to offer the invention is a method [RF patent №2445980 C1, CL. A61L 101/46, 2010] production of the polymer complex, which has antiseptic properties and antiseptic coating on its base, where the antimicrobial coating is a mixture of polyvinyl butyral and complex dimethylammoniumchloride with a copolymer of styrene with maleic anhydride, previously subjected to chemical modification by interaction with alkali for disclosure anhydrite cycles with the formation of carboxylate groups. Coating of a mixture of this complex is fully prolongirovanne inhibit the growth of microorganisms. However, a significant disadvantage of this coating is its interaction with the surface of the aluminium alloy, leading to corrosion and last appearance on the surface of the cavern.

The technical result of the present invention is fully extended protection products from aluminum alloys from fouling by microorganisms, prevent corrosion changes the surface of these alloys.

This technical result is achieved by the proposed method, antiseptic processing of aluminum alloys, which consists in forming on the surface coverings of complexes of dimethylammoniumchloride containing alkyl group from C10to C14or their mixtures from C8to C16with copolymers of styrene with maleic and the hydride, pre subjected to chemical modification to the disclosure anhydrite cycles in the processing solutions of alkali, the amount of alkali which varies from 50 to 60% relative to the amount needed to neutralize all of the resulting carboxyl groups, and mixtures of these complexes with butyral composition, wt.%: complex - 25-40; butyral - 60-75.

Coating was formed on the sample plates made of aluminium alloy, the surface of which was previously worn flannel cloth or cotton-gauze swab soaked in ethyl or isopropyl alcohol. The solution for forming the coating was applied with a brush, evenly distributed across the surface of the sample. The operation was repeated three times. After each application, the coating was dried in the air. In the case of forming coatings from mixtures of polyvinyl butyral with complex solutions for the formation of coatings were prepared by mixing at a predetermined ratio of the solution of the complex with a solution of polyvinyl butyral, followed by stirring the obtained solution with a magnetic stirrer until a homogeneous mass.

Chemical modification of a copolymer of styrene with maleic anhydride in order to disclose the anhydrite cycles in parts of the maleic anhydride with the formation of carboxylate and carboxyl groups was carried out with aqueous solutions of alkali the eyes. To do this in a flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded calculated quantity of copolymer and an aqueous solution of alkali metal hydroxide. The process is conducted in a boiling water bath, the resulting copolymer was passed into the solution. For more complex dimethylammoniumchloride this solution chemically modified copolymer with vigorous stirring was mixed with an aqueous solution of dimethylammoniumchloride. The last was taken in a reaction rate of 1 mole per 1 g·EQ. carboxylate groups in chemically modified copolymer. The complex was separated from solution as a white precipitate, which was washed with water and dried in vacuum at 40°C.

Coatings formed from solutions of the polymer complexes or mixtures thereof with butyral in an appropriate solvent. The solutions were applied with a brush in several layers, drying after application of each layer.

When testing the antimicrobial activity of the coatings were determined their fungicidal and bactericidal properties on the duration and degree of protection of aluminium alloy under conditions periodically generated high microbial load. Evaluation of antimicrobial activity of the samples was conducted by determining gribomont in points according to GOST 9.050-75 method a and against the bacterium is about mushroom Association, which has been prepared in an environment of čapek-doksa, diluted with distilled water in the ratio 1:5. The Association of the cultures consisted of Staphylococcus epidermidis, Bacillus polymyxa, Bacillus pumilus, Penicillium expansum, Aspergillus niger and Cladosporium cladosporioides, which have monthly inoculable 5 samples of materials to each experience to obtain reliable data. The content of each species in a mixture comprised of (1-2)×105colony forming units (CFU) on 1 cm2square. Infected samples were placed in a thermostat and incubated at 28°C and a relative humidity ≥90% within 3 months sampling after 90 days to determine the number of viable units of microorganisms on the studied materials. For this purpose, the samples otbelivanie in physiological solution and washings were sown on the surface of nutrient media: protection of čapek-doksa to determine CFU of fungi, environment TCA (trypto-soy agar) to determine CFU of bacteria.

The quality of the surface formed with the coating and its corrosion changes were evaluated using a stereomicroscope "Stemi 2000".

The following examples illustrate the proposed method for the fabrication of polymeric complex and antiseptic coating on aluminum alloys.

Example 1. To obtain a copolymer of styrene with maleic anhydride copolymerization was carried out in boiling benzene in a 3-necked round bottom to the forehead, equipped with a mechanical stirrer, reflux condenser and thermometer. Download: benzene - 509 ml, maleic anhydride - 49 g (0.5 mol), styrene - 52 g (57.4 ml, 0.5 mol), the initiator 2,2'-azobis(isobutyronitrile) and 0.5 G. of Benzene was preliminarily dried by keeping the above calcined alumina, styrene was purified from inhibitor by using sodium hydroxide and dried calcium chloride. In the process of copolymerization, the copolymer was allocated in the form of a white solid precipitate. At the end of the process (20 min) copolymer was separated from the solution on a Buechner funnel, washed three times with fresh portions of hexane and dried in a vacuum drying Cabinet at a temperature of 80°C. Srednevozrastnoe molecular weight of the copolymer is 3.2×105. According to titration and elemental analysis of the copolymer contains 53 mol-link % links maleic anhydride.

To obtain a modified copolymer, in which 60% of the groups of maleic anhydride converted into carboxylate groups, the modification was performed with an aqueous solution of sodium hydroxide. To do this in a flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded 2,08 g (10, 9 mmol-link maleic anhydride) copolymer and 0,525 g (of 13.1 mmol) of sodium hydroxide dissolved in 50 ml of water. The process is conducted in a boiling water bath for 5 hours. At the end of the process the whole copolymer is passed into the solution, the pH of Atherstone modified copolymer is 8. From a solution of the copolymer besieged 1,4-dioxane, separated on the filter from the solution and dried in vacuum at room temperature. This modified copolymer was obtained complex with Catalina AB (dimethylallyl(C12-14)benzylammonium). For this to 20,0 ml 4,18% aqueous solution of the modified copolymer with stirring dropwise added of 10.58 ml 14,85% aqueous solution of catamine AB. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of catamine AB. Released a white precipitate of the complex was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration - 4,84 g/DL).

For the evaluation of antimicrobial activity of the coating samples of aluminium alloy 3-fold infected bacterial-fungal Association. In table.1 shows the content of SOME bacteria and fungi these samples and samples of the prototype. As control was used samples of aluminium alloy uncoated.

Table 1
The content of bacteria and fungi (CFU) of example 1, the sample prototype and the control sample without coating and characterization of these behavior is Hosta
Example No.3x infectionCharacteristics of the surface at the end of the test
bacteriamushrooms
10∗0∗smooth
the placeholder0∗0∗there are caverns
control5,0×107of 3.2×105smooth
Note: the 0∗ - SOME content is less than 50 on the sample at 3-fold repetition sample

As can be seen from this table that the number of microorganisms with 3-fold contamination on the samples of example 1 and sample prototype was significantly lower than in control samples. Funginertness samples according to GOST 9.050-75 matches in example 1 and the prototype is 0 points, and the control sample is equal to 4 points. The surface of the samples of example 1 and control sample without coating smooth on the surface of the sample prototype has pitting.

Example 2. The coating on the plates of the Plava AMg6 aluminium formed from a mixture of solutions in isopropyl alcohol complex, synthesized as described in example 1, and polyvinyl brand "Mowital B60T" containing 69-72 wt.% acetylenic links, 2 wt.% acetate units and 24 to 27 wt.% the residual parts of vinyl alcohol. The mixture solutions were prepared by mixing 2 volumes of a solution of complex (concentration - 4,84 g/DL) and 3 volumes of a solution of polyvinyl butyral brand "Mowital B60T" (concentration - 5,09 g/DL). Maintenance of the complex in the coating 39%.

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Example 3. A copolymer of styrene with maleic anhydride obtained as described in example 1. To obtain a modified copolymer, in which 50% of the groups of maleic anhydride converted into carboxylate groups, in flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded 2,62 g (13,77 mmol-link maleic anhydride) copolymer and 0,551 g (13,77 mmol) of sodium hydroxide dissolved in 50 ml of water. The process is conducted in a boiling water bath for 12 hours. At the end of the process the whole copolymer is passed into the solution, the pH of this solution of the modified copolymer is 6. From a solution of the copolymer besieged 1,4-dioxane, separated on the filter from the solution and dried in vacuum at room temperature is to constant weight. This saponified copolymer was obtained complex with Catalina AB. For this to 20,0 ml 4,72% aqueous solution of the modified copolymer with stirring dropwise added 10,15 ml 14,81% aqueous solution of catamine AB. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of catamine AB. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration of 4.3 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Example 4. Synthesis of a copolymer of styrene with maleic anhydride and its modification by sodium hydroxide was carried out as described in example 1. This saponified copolymer was obtained complex with dimethylallyl(C8-16)benzylammonium. For this to 12.0 ml 4,18% aqueous solution of the modified copolymer with stirring dropwise added 5.8 ml of 15.0% aqueous solution of dimethylallyl(C8-16)benzylaminopurine. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of dimethylallyl(C8-16)benzylammonium is Yes. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration of 5.1 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission. The surface of the samples after testing smooth.

Example 5. The coating on the plates of aluminium alloy AMg6 formed from a mixture of solutions in isopropyl alcohol complex, synthesized as described in example 4, and polyvinyl brand "Mowital B60T". The mixture solutions were prepared by mixing 2 volumes of a solution of complex (concentration of 5.1 g/DL) and 3 volumes of a solution of polyvinyl butyral (concentration 5,09 g/DL.) Maintenance of the complex in a coverage of 40%.

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Example 6. Synthesis of a copolymer of styrene with maleic anhydride and its modification by sodium hydroxide was carried out as described in example 1. This saponified copolymer was obtained complex with dimethyldioctadecylammonium. For this is about to 13,0 ml 4,18% aqueous solution of the modified copolymer with stirring with a magnetic stirrer was added to 1.15 g dimethyldioctadecylammonium, dissolved in 20 ml of hot (50-60°C) distilled water. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of dimethyldioctadecylammonium. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration - 5.0 g/DL).

On the thus formed coating was observed the growth of fungi. According to GOST 9.050-75 after 2 months it corresponded to 2-3 points. With 2-fold infection that cover SOME mushrooms corresponded to 1.6×105and SOME bacteria is 3.2×103.

The surface of the samples after testing smooth.

Example 7. The coating on the plates of aluminium alloy AMg6 formed from a mixture of solutions in isopropyl alcohol complex, synthesized as described in example 6, and polyvinyl brand "Mowital B60T". The mixture solutions were prepared by mixing 2 volumes of a solution of complex (concentration - 5.0 g/DL) and 3 volumes of a solution of polyvinyl butyral (concentration - 5,09 g/DL). Maintenance of the complex in a coverage of 40%.

On the thus formed coating was observed the growth of fungi. According to GOST 9.050-75 after 1 month he met 1-2 points. At 1 times the contamination of this surface SOME mushrooms soo is welcomed to 5.4×10 2and SOME bacteria is 2.6×103.

The surface of the samples after testing smooth.

Example 8. Synthesis of a copolymer of styrene with maleic anhydride and its modification by sodium hydroxide was carried out as described in example 1. This saponified copolymer was obtained complex with dimethylammoniumchloride. For this to 15.0 ml of 4.1% aqueous solution of the modified copolymer with stirring dropwise added 12,71 ml of 7.75% aqueous solution of dimethylammoniumchloride. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of dimethylammoniumchloride. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy was formed from a solution in methyl alcohol (concentration - 5.0 g/DL).

On the thus formed coating was observed the growth of fungi. According to GOST 9.050-75 after 1 month he met 2-3 points. At 1 times the contamination of this surface SOME mushrooms corresponded to 2.4×105and SOME bacteria - 4,8×104.

The surface of the samples after testing smooth.

Example 9. The coating on the plates of aluminium alloy AMg6 formed from a mixture of solutions in methyl alcohol complex, synthesized as described in examples is e 8, and polyvinyl brand "Mowital B60T". The mixture solutions were prepared by mixing 2 volumes of a solution of complex (concentration - 5.0 g/DL) and 3 volumes of a solution of polyvinyl butyral (concentration 5,09 g/DL). Maintenance of the complex in a coverage of 40%.

On the thus formed coating was observed the growth of fungi. According to GOST 9.050-75 after 1 month the growth of fungi was absent for 2 months match 3 points. With 2-fold infection that cover SOME mushrooms corresponded to 1.0×106and SOME bacteria is 3.2×104.

The surface of the samples after testing smooth.

Example 10. A copolymer of styrene with maleic anhydride obtained as described in example 1. To obtain a modified copolymer, in which 80% of the groups of maleic anhydride converted into carboxylate groups in a flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded 2.15 g (11.3 mmol-link maleic anhydride) copolymer and 0.72 g (18,10 mmol) of sodium hydroxide dissolved in 50 ml of water. The process is conducted in a boiling water bath for 4 hours. At the end of the process the entire copolymer passed into solution, from which it besieged 1,4-dioxane, separated on the filter from the solution and dried in vacuum at room temperature to constant weight, the pH of the aqueous solution of the modified copolymer is 11. This saponified copoly the EPA was obtained complex with Catalina AB. For this to 20,0 ml 4,86% aqueous solution of the modified copolymer with stirring dropwise added 15,81 ml 14,85% aqueous solution of catamine AB. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of catamine AB. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration is 5.28 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

After finishing the test on the sample surface was observed pitting.

Example 11. The coating on the plates of aluminium alloy AMg6 formed from a mixture of solutions in isopropyl alcohol complex, synthesized as described in example 10, and polyvinyl brand "Mowital B60T". The mixture solutions were prepared by mixing 1 volume of a solution of complex (concentration is 5.28 g/DL) and 3 volumes of a solution of polyvinyl butyral (concentration - 5,09 g/DL). Maintenance of the complex in the coating 26%.

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

After finishing the test on the surface of the samples and was observed pitting.

Example 12. A copolymer of styrene with maleic anhydride obtained as described in example 1. To obtain a modified copolymer, in which 40% of the groups of maleic anhydride converted into carboxylate groups, in flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded 2,07 g (10.9 mmol-link maleic anhydride) copolymer and 0.35 g (8,72 mmol) of sodium hydroxide dissolved in 50 ml of water. The process is conducted in a boiling water bath for 24 hours. At the end of the process the entire copolymer passed into solution, from which it besieged 1,4-dioxane, separated on the filter from the solution and dried in vacuum at room temperature to constant weight, the pH of the aqueous solution of the modified copolymer is 6. This saponified copolymer was obtained complex with Catalina AB. For this to 20,0 ml of 3.25% aqueous solution of the modified copolymer with stirring dropwise added 29,18 ml of 2.9% aqueous solution of catamine AB. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of catamine AB. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in N,N-dimethylformamide (concentration of 5.0 g/DL). The solution applied and the brush in 4 layers with an interval of 24 hours. After application of each layer was dried at a temperature of 70-80°C.

On the thus formed coating has the growth of fungi. According to GOST 9.050-75 after 1 month the growth of fungi is equivalent to 5 points. At 1 times the contamination of this surface SOME mushrooms corresponded to 6.0×107and SOME bacteria - 2,82×104.

The surface of the samples after testing smooth.

Example 13. The copolymerization of styrene with maleic anhydride was carried out in dried ethyl ketone at boiling point in a 3-necked flask fitted with mechanical stirrer, reflux condenser with a dropping funnel and a thermometer. Download: ethyl ketone 40 ml, maleic anhydride and 9.8 g (0.1 mol), styrene - 10.4 g (11,4 ml, 0.1 mol), the initiator 2,2'-azobis(isobutyronitrile) - 0,6, For this purpose a solution of maleic anhydride in ethyl ketone was loaded into a 3-necked flask and brought to a boil. To this solution is added dropwise during 40 min under vigorous stirring was added an initiator solution in styrene. Then the process is continued 110 minutes At the end of the process the copolymer from solution besieged in the form of a white powder with petroleum ether and separated from the solution on a Buechner funnel, washed three times with fresh portions of petroleum ether and dried in a vacuum drying Cabinet. According to the elemental analysis of the copolymer contains 61 mol-link % parts of maleic anhydride and 39 mol-link % links styrene. Srednevozrastnoe molecular weight of this copolymer is 2.4×104. To obtain a modified copolymer, in which 60% of the groups of maleic anhydride converted into a carboxylate group modification was performed with an aqueous solution of sodium hydroxide under the same conditions as in example 1. To this flask was loaded 4,47 g (27,15 mmol-link maleic anhydride) and 1,305 g (32,58 mmol) of sodium hydroxide dissolved in 90 ml of water. The complex of this modified copolymer with Catalina AB also synthesized as described in example 1. For this to 10.0 ml 5,07% aqueous solution of the modified copolymer with stirring dropwise added 12.5 ml to 7.61% aqueous solution of catamine AB. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of catamine AB. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration of 5.1 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Examples 14-17. A copolymer of styrene with maleic anhydride, his modifitsirovannuyu sodium derivative and complex Catalina AB obtained as described in example 1.

The coating on the plates of aluminium alloy AMg6 formed from a mixture of solution in isopropyl alcohol of this complex and polyvinyl brand "Mowital B60T" for different ratios of components in the mixture (table.2).

Table 2
Coating formulations for examples 2, 14-17 on the plates of aluminium alloy AMg6, the growth of fungi in points and the content of bacteria and fungi (CFU)
Example No.The composition, wt.%The growth of fungi, pointsSOME
the complex of example 1the butyralmushroomsbacteria
23961000
142575000
151090 14×1037×104
163070000
175050---

From the data of this table shows that the coating in example 15 does not fully inhibit the growth of microorganisms, while not causing corrosion damage to the surface. Solutions of a mixture of complex and polyvinyl butyral, containing more than 40 wt.% complex (example 17) stratified, in connection with which of them are unable to form a uniform coating. The surface of the samples in examples 2, 14-16 at the end of the smooth tests.

Examples 18-21. The coating on the plates of aluminium alloy AMg6 formed from a mixture of solutions in isopropyl alcohol as described in example 2, compound, synthesized as described in example 1, and polyvinylbutyral differing content acetylenic and vinylstyrene links (PL.3). Maintenance of the complex in coatings - 30 wt.%.

Table 3
The chemical structure of different types of polyvinylbutyral
Example No.Mark poliovirusConcentration units mol-link %
acetalineacetatevinylstyrene
18"Mowital B60T"69-72224-27
19"Mowital B60HH"81-84212-16
20"Mowital VN"75-78318-21
21"Mowital VT"68-72324-27

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission. The surface of the samples after testing smooth.

Example 22. Synthesis of a copolymer of styrene with maleic anhydride and its modification hydroxide NAT the Oia conducted as described in example 1. This modified copolymer was obtained complex with dimethylmethyleneammonium. For this to 15.0 ml of 4.1% aqueous solution of the modified copolymer with stirring dropwise added 21,37 ml of a 5.0% aqueous solution of diethylmethylbenzenediamine. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate sodium per 1 mol of diethylmethylbenzenediamine. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration of 4.9 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Example 23. Synthesis of a copolymer of styrene with maleic anhydride and its modification by sodium hydroxide was carried out as described in example 1. This modified copolymer was obtained complex with dimethylmethyleneammonium. For this to 15.0 ml of 4.1% aqueous solution of the modified copolymer with stirring dropwise added 25,26 ml of a 5.0% aqueous solution of dimethylammoniumchloride. The reagents were mixed at the rate of 1 g·EQ. groups is carboxylate sodium per 1 mol of dimethylammoniumchloride. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration of 5.1 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Example 24. Synthesis of a copolymer of styrene with maleic anhydride was carried out as described in example 1. To obtain a modified copolymer, in which 60% of the groups of maleic anhydride converted into carboxylate groups, the modification was performed with an aqueous solution of potassium hydroxide. To do this in a flat-bottomed flask, equipped with reflux condenser and magnetic stirrer, was loaded with 2.5 g (13,08 mmol-link maleic anhydride) copolymer and 0.61 g (15,72 mmol) of potassium hydroxide dissolved in 50 ml of water. The process is conducted in a boiling water bath for 5 hours. At the end of the process the whole copolymer is passed into the solution, the pH of this solution of the modified copolymer is 8. From a solution of the copolymer besieged 1,4-dioxane, separated on the filter from the solution and dried in vacuum at room temperature. This modified copolymer was placenames with Catalina AB. For this to 15.0 ml 5,71% aqueous solution of the modified copolymer with stirring dropwise added of 10.58 ml 14,58% aqueous solution of catamine AB. The reagents were mixed at the rate of 1 g·EQ. groups of carboxylate potassium per 1 mol of catamine AB. There were white precipitate of the complex, which was washed with water and dried to constant weight in a vacuum drying Cabinet at 40°C.

Coverage of this complex on the plates of aluminium alloy AMg6 formed from a solution in isopropyl alcohol (concentration of 5.2 g/DL).

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Examples 25-28. The coating on the plates of aluminum alloys D16AT, AK, D16T and AD1 formed from a solution in isopropyl alcohol (concentration - 4,84 g/DL) complex synthesized as described in example 1.

On the thus formed coating the growth of fungi according to GOST 9.050-75 missing and not found SOME bacteria and fungi with 3-fold transmission.

The surface of the samples after testing smooth.

Thus, the full extended protection products from aluminum alloys from microorganisms, prevent corrosion changes the surface of these products is achieved by forming on their surface is rnoth coatings from complex dimethylammoniumchloride, containing alkyl group from C10to C14or their mixtures from C8to C16with a copolymer of styrene with maleic anhydride, previously subjected to chemical modification to the disclosure anhydrite cycles in the processing solutions of alkali, the amount of alkali which varies from 50 to 60% relative to the amount needed to neutralize all of the resulting carboxyl groups (examples№№1, 3, 4, 13, 22-28), and mixtures of this complex with butyral containing 25-50 wt.% complex examples№№2, 5, 14, 16, 18-21). The use of complexes with individual dimethylammoniumchloride, in which an alkyl group is shorter than10(examples # 8 and # 9), and longer With14(examples 6 and 7), leads to a decrease in antimicrobial coating properties, incomplete suppression of growth of microorganisms. The use of complexes of copolymers, in which more than 60% of the carboxyl groups formed during the disclosure anhydrite cycles parts of maleic anhydride, is converted into carboxylate, leads to corrosion damage to the surface of the material with the formation of pitting (samples No. 10 and 11). The use of complexes of copolymers in which less than half of the carboxyl groups formed during the disclosure anhydrite cycles parts of maleic anhydride, is converted into carboxylate, not p is igodit to complete and prolonged suppression of the growth of microorganisms (sample No. 12). The use of mixtures of these complexes with butyral, containing less than 25 wt.% complex, does not provide a complete and prolonged suppression of the growth of microorganisms (sample No. 15). The formation of homogeneous coatings from mixtures containing more than 40 wt.% complex, it is not possible, because the solutions of these mixtures of such stratified composition (sample No. 17).

The proposed method for the fabrication of polymeric complex has antiseptic properties and antiseptic coating on its basis can be applied for surface modification of materials from aluminum alloys when they are:

- long-term operation in space objects;

in submarines;

- ground or underground confined spaces;

- in the shops of the net Assembly;

in areas that meet certain requirements for microbial load their surface class 100, 10000 and 100000.

A method of manufacturing an antiseptic coating to products made of aluminium alloy, it does not cause corrosion, characterized in that the coating formed from the complex of dimethylammoniumchloride containing alkyl group from C10to C14or a mixture of alkyl groups of C8to C16with a copolymer of styrene with maleic anhydride, previously subjected to chemical modification to the disclosure and the hydride cycles with the formation of carboxyl groups, from 50 to 60% of which are neutralized with the formation of carboxylate groups, or a mixture of this complex with butyral when their ratios, wt%:

antiseptic polymer complex25-40
the butyral60-75



 

Same patents:

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing block-copolymers which contain a reactive functional group. Described is a method of producing a block-copolymer, involving: a) reaction of an acrylic monomer, having functional groups which are epoxy, acid, anhydride, amine, amide and hydroxy groups, and one or more vinyl monomers in the presence of a free-radical initiator a stable free radical at the first step to obtain a reaction product which contains a residual unreacted acrylic monomer; and b) reaction at the second step of one or more vinyl monomers with the reaction product from the first step to obtain a second block which contains a residual unreacted acrylic monomer. Also described are versions of said method of producing a block-copolymer. Described is a block-copolymer obtained using said methods, containing: a) a first block which contains monomer links of a functionalised acrylic monomer, having functional groups which are epoxy, acid, anhydride, amine, amide and hydroxy groups, and monomer links of a vinyl monomer; and b) a second block which contains monomer links of one or more vinyl monomers and monomer links of a functionalised acrylic monomer, having functional groups which are epoxy, acid, anhydride, amine, amide and hydroxy groups in the first block. Described is a thermoplastic polymer composition which is used to obtain materials with high impact resistance and mechanical strength, which contains: (a) 1-98 wt % of a first thermoplastic, having functional groups selected from a group consisting of amine, amide, imide, carboxyl groups, carbonyl, carbonate ester, anhydride, epoxy, sulpho, sulphonyl, thionyl, sulphydryl, cyano and hydroxy; (b) 0.01-25 wt % of said block-copolymer, which contains a functional group which is capable of reacting with the functional group in the thermoplastic; and (c) 1-98 wt % of a second thermoplastic polymer which is miscible or compatible with the second block of said block-copolymer.

EFFECT: obtaining block-copolymers which can be used as reactive compatibility agents of thermoplastic mixtures of polymers.

31 cl, 10 dwg, 14 tbl, 56 ex

FIELD: chemistry.

SUBSTANCE: invention relates to emulsifying polymers and use of these polymers for stable emulsification of hydrophobic additives in aqueous concrete plasticisers. Disclosed is a polymer P, obtained via copolymerisation (a) of at least one ethylenically unsaturated monomer A selected from a group consisting of unsaturated mono- and dicarboxylic acids, sulphonic acids, phosphonic acids in form of free acids or salts or partial salts or halide or anhydride, with (b) at least one ethylenically unsaturated monomer B of formula ,

or ,

where radicals and coefficients are as described in the claim and (c) with at least one ethylenically unsaturated monomer C of formula

,

where radicals and coefficients are as described in the claim and with (d) at least one ethylenically unsaturated monomer D of formula

,

where radicals and coefficients are as described in the claim and optionally (e) with at least one basic ethylenically unsaturated monomer E of formula ,

where radicals and coefficients are as described in the claim and optionally (f) with at least one other ethylenically unsaturated monomer W. Use of the polymer as a plasticiser for water-curable compositions and a water-curable composition are also disclosed.

EFFECT: polymer improves quality of mortar.

19 cl, 5 tbl

The invention relates to methods of producing cross-linked copolymers of maleic anhydride with styrene, in particular the production of ammonium salts polyamide copolymer of maleic anhydride and styrene, Recoletos ethylene glycol, which is used to obtain formulations of pesticides, as well as cosmetic, pharmaceutical and veterinary products

The invention relates to methods for film-forming polymers for paints and varnishes, in particular the production of film-forming copolymer of the bottoms of the distillation of styrene (KORS) and carbonyl compounds

Water disinfectant // 2533583

FIELD: chemistry.

SUBSTANCE: invention relates to means of purifying and disinfecting different types of water. Described is a disinfectant which contains a first polyhexamethylene guanidine hydrochloride component, a second alkyldimethylbenzylammonium chloride component and water, wherein content of the components in the solution is selected in the following amounts, wt %: first component 7-34.5, second component 1.75-6.9, water - the balance.

EFFECT: disinfection of drinking water.

3 tbl

FIELD: chemistry.

SUBSTANCE: group of invention relates to a synergistic antimicrobial composition which includes a zinc salt of glyphosate and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, and is intended for controlling the level of fungi and algae. The group of inventions also provides a method of inhibiting growth or controlling growth of microorganisms in building material by adding said synergistic antimicrobial composition, a coating composition containing said synergistic antimicrobial composition and a dry film made from said coating composition.

EFFECT: use of the group of inventions increases efficiency of inhibiting growth of microorganisms, provides more precise control of the growth of microorganisms without affecting health and/or the environment.

12 cl, 7 tbl

FIELD: medicine.

SUBSTANCE: tableted antimicrobial composition contains polyhexamethylene guanidine hydrochloride (PHMH) in a combination with at least one ingredient specified in a group: quaternary ammonium compound (QAC), N,N-bis-(3-aminopropyl)dodecylamine and persol, as well as with an alkaline metal iodide and ammonium iodide. The antimicrobial composition has the following ratio of ingredients: PHMH - 10 to 70 wt %; QAC, N,N-bis(3-aminopropyl)dodecylamine and/or persol - 1 to 30 wt %; an alkaline metal iodide and ammonium iodide - 0.1 to 20 wt %.

EFFECT: using the invention provides the fast-acting tableted antimicrobial composition having a wide antimicrobial spectrum and a higher level of biocidal activity.

5 cl, 2 tbl, 2 ex

FIELD: agriculture.

SUBSTANCE: invention relates to the field of poultry industry and is intended for sanation of poultry hatching eggs. The method comprises processing the egg surface with aqueous solution of preparation based on milk whey with lactulose and quaternary ammonium compound trimethyloctadecyl ammonium bromide. As the aqueous solution of the preparation based on milk whey with lactulose and quaternary ammonium compound trimethyloctadecyl ammonium bromide 0.1-0.2% aqueous solution of the preparation is used, taken in equal proportions and diluted with water in a ratio of 1:10. Hatching eggs are processed 2-4 hours prior to their laying for incubation.

EFFECT: use of claimed method enables to carry out effectively sanation of poultry hatching eggs.

1 tbl, 1 ex

FIELD: cosmetology.

SUBSTANCE: agent comprising ethanol, glycerol, Carbopol ultrese and softened water according to the invention comprises aminomethylpropanol, essential oil selected from the group: eucalyptus essential oil, lemon essential oil, peppermint essential oil, anise essential oil, jasmine essential oil with the following ratio of components in g per 100 g of gel: ethanol 65.0-66.0; glycerol 1.0-2.0; Carbopol ultrese 0.16-0.18; aminomethylpropanol 0.06-0.08; essential oil 0.005-0.03; softened water - up to 100.0.

EFFECT: invention has a high antimicrobial activity against pathogenic bacteria, fungi and viruses and provides safety for life and health of people without causing allergy.

4 cl, 4 ex

FIELD: chemistry.

SUBSTANCE: biocidal composition for soaking napkins contains benzethonium chloride, sodium hydroxymethylglycinate, glycerine, decyl polyglucose, niacinamide, liposentol hydro, phenylmethanol and distilled water. Components are used in a defined ratio given in wt %.

EFFECT: invention improves biocidal properties of the napkin soaking composition.

3 tbl, 1 ex

Disinfectant // 2514097

FIELD: chemistry.

SUBSTANCE: invention discloses a disinfectant and can be used in prevention and treatment facilities, at first aid facilities, disinfection facilities, child care centres, public catering facilities, public utilities, transportation, veterinary, agriculture, food industry enterprises and other sectors, as well as for pre-sterilisation cleaning of medical items, including surgical and dental instruments, rigid and flexible endoscopes and other instruments. The disinfectant contains catamine AB, isobornyl acetate, isopropanol, α-pinene, glutaric aldehyde, glycerine, a nonionic surfactant and water in defined ratios.

EFFECT: disinfectant does not cause corrosion in articles made of metal and decomposition of metals and endoscope units; does not cause organic contamination.

3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine, namely to clinical allergology, and may be used for extracorporeal allergen denaturation. That is ensured by treating a surface of objects with an allergen-denaturing composition. The composition contains calcium chloride or calcium acetate and lanthanum chloride or lanthanum nitrate in certain proportions.

EFFECT: combinations of the above metal salts selected in certain proportions provide the effective allergen denaturation ex vivo by a synergistic denaturation action of the given ingredients.

9 cl, 4 tbl

FIELD: medicine.

SUBSTANCE: synergistic antimicrobial composition contains a zinc salt of glyphosate and thiabendazole, wherein the weight ratio of thiabendazole to the zinc salt of glyphosate is from 0.1:1 to 10:1. A method of inhibiting the growth or controlling the growth of microorganisms in a construction material involves the step of adding the synergistic antimicrobial composition. A coating composition comprises the given synergistic antimicrobial composition. A dry film is made by a process comprising applying a layer of the synergistic composition to a substrate and drying.

EFFECT: controlling the growth of microorganisms, fungi, algae on the finish surfaces of the construction materials.

6 cl

FIELD: chemistry.

SUBSTANCE: described is a method of producing a highly purified disinfectant which contains polyhexamethylene guanidine hydrochloride, characterised by that flush water from production of polyhexamethylene guanidine hydrochloride in solid form is used. The flush water is mixed with 25% NaCl solution in ratio of 1:1 (polyhexamethylene guanidine hydrochloride solution with impurities: NaCl solution) while stirring constantly for 1 hour at temperature in the range of 50-60°C. Stirring is stopped and the mixture is cooled to 5°C, thereby dividing the mixture into two parts; the bottom part is drained, neutralised and sent for recycling and the top part containing up to 60-70% polyhexamethylene guanidine hydrochloride is further diluted to 50% with an aqueous solution of quaternary ammonium salts (QAS) to QAS concentration of not higher than 5%.

EFFECT: extracting highly purified, concentrated high-molecular weight polyhexamethylene guanidine hydrochloride from flush water, reducing the amount and toxicity of waste water, improving disinfecting properties and increasing output of the commercial-grade product when producing polyhexamethylene guanidine hydrochloride in solid form, reducing cost.

1 cl, 1 ex, 2 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to disinfectants of wide spectrum applied in medicine, veterinary, food industry, communal household sphere, public catering enterprises, laboratories of any profile, and is intended for treatment of hands, treatment of patients' operation and injection field skin, decontamination of gloves, put on hands of medical staff, disinfection of difficult for access surface at enterprises of food industry, public catering, as well as in any other organisations. Invention represents disinfectant, which contains octenidine dihydrochloride, propanol-1, propanol-2, citric acid, lavender essential oil and softened water.

EFFECT: invention provides creation of highly efficient disinfectant, which possesses high antimicrobial activity with respect to Gram-positive and Gram-negative bacteria, fungi of genus Candida and Trichophyton, as well as viruses.

2 ex

FIELD: chemistry.

SUBSTANCE: group of invention relates to a synergistic antimicrobial composition which includes a zinc salt of glyphosate and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, and is intended for controlling the level of fungi and algae. The group of inventions also provides a method of inhibiting growth or controlling growth of microorganisms in building material by adding said synergistic antimicrobial composition, a coating composition containing said synergistic antimicrobial composition and a dry film made from said coating composition.

EFFECT: use of the group of inventions increases efficiency of inhibiting growth of microorganisms, provides more precise control of the growth of microorganisms without affecting health and/or the environment.

12 cl, 7 tbl

FIELD: medicine.

SUBSTANCE: synergistic antimicrobial composition contains a zinc salt of glyphosate and thiabendazole, wherein the weight ratio of thiabendazole to the zinc salt of glyphosate is from 0.1:1 to 10:1. A method of inhibiting the growth or controlling the growth of microorganisms in a construction material involves the step of adding the synergistic antimicrobial composition. A coating composition comprises the given synergistic antimicrobial composition. A dry film is made by a process comprising applying a layer of the synergistic composition to a substrate and drying.

EFFECT: controlling the growth of microorganisms, fungi, algae on the finish surfaces of the construction materials.

6 cl

FIELD: medicine.

SUBSTANCE: invention refers to disinfection. The experimental method for the elimination of pathogenic and opportunistic microorganisms is characterized by the fact that a mixture containing the pathogenic and opportunistic microorganisms are processed with a disinfection composition which is metal oxyhydrate gel prepared by alkaline metal chloride deposition by 2% ammonia in a min. 5-litre reactor; fresh metal oxyhydrate 20-10-6 m3 is placed in an electrochemical cells with graphite electrodes of a charged cluster metal particle generator; what is added is a bacterial solution of the medium of 105 microbial cells in 1 ml dissolved in distilled water 10 ml; the medium is exposed to polarized currents of the cluster oxyhydrate particles of metal oxyhydrate gel for 2 to 6 hours; metal oxyhydrate gels are prepared by using metal chloride salts presented by zirconium or iron chloride salts with the electrode distance no more than 70 mm.

EFFECT: invention provides the more effective inactivation of pathogenic and opportunistic microorganisms that are infectious agents in human and animals.

7 tbl, 2 dwg, 6 ex

Antiviral agent // 2496522

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions discloses an antiviral agent (versions) able to inactive a virus. The antiviral agent characterised by containing the basic substance, cuprous microparticles, and inorganic microparticles to fix the cuprous microparticles on the basic substance. The inorganic microparticles are coupled together by chemical bonds formed between silane monomers found on the surface, and each of the inorganic microparticles is coupled with the basic substance by a chemical bond between silane monomer and the basic substance for the purpose of forming the areas wherein the above cuprous microparticles are expected to be accumulated.

EFFECT: group of inventions provides high antiviral activity.

16 cl, 3 tbl, 7 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfection. The composition contains hydrogen peroxide and an aqueous solution of copper or one of its derivatives, such as copper salts, as well as at least one salt of an anionic surfactant inhibiting decomposition of hydrogen peroxide in the presence of copper. The composition may be prepared immediately before use by mixing the aqueous solution of copper and the aqueous solution of hydrogen peroxide.

EFFECT: invention provides simultaneous disinfection and decontamination of the objects infected by special infectious agents (NCTA), such as prions, and common infectious agents (CTA), such as bacteria, yeast, viruses, mould spores, mycobacteria, bacterial spores.

23 cl, 5 tbl

FIELD: medicine.

SUBSTANCE: invention refers to public health, veterinary science, food processing, pharmaceutical and biotechnological productions. Disinfection objects are processed by the system of disinfectants consisting of at least two preparations, wherein at least one of the preparations is specified in a group of oxidants, namely oxygen-chlorine substances, and at least one of the preparations is specified in a group of non-oxidants, including, QACs - quaternary ammonium compounds, tertiary amines, aldehydes, guanidines. The system of disinfectants is packed within a package so that each preparation is placed separately, and each following preparation is used only after the previous preparation has been consumed completely.

EFFECT: invention provides the controlled rotation of disinfectants that prevents the developing acquired microorganism resistance.

3 ex

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