Methods of treating patients with locally advanced uterine cancer
SUBSTANCE: there are performed beam therapy, intracavitary therapy and chemotherapy. For 5-7 days before the beginning of the radiation, Colagel-Beta with 1 β-interleukin 20 ml is introduced into a vaginal tube daily. Each session of the intracavitary therapy is preceded by introducing Colegel with 5-fluoruracil 20-25 ml into an uterine cavity and exposed for 30-40 minutes. Besides, from the beginning of the beam therapy 40-50 minutes after the radiation session, sodium alginate gel 20 ml containing methyluracil, dimethyl sulphoxide and hydrocortisone are introduced into a rectum and a bladder in a therapeutically effective amount. 5-10 procedures are performed.
EFFECT: providing faster regression of the tumour, reducing the rate and severity of radiation injuries of the rectus and bladder adjacent with the uterus with no risk of severe systemic toxic manifestations, including in senior patients with comorbid inoperable diseases and extended tumours.
The invention relates to medicine, namely to Oncology, and can be used for the treatment of patients with locally advanced common forms of cervical cancer or cancer of the womb.
In the incidence of malignant neoplasms of the female population of Russia cancer of uterine body takes 3rd place (7.1%) and 1st place among malignant tumors of the female genitalia, in the structure of morbidity in women with malignant tumors in the world, cancer of the uterus occupies the 7th place.
Radiation therapy is used in 80% of patients with carcinoma of the cervix and uterine body as a combined treatment, as well as an independent method of treatment. But still 35-45% of patients, despite treatment, die from the underlying disease, and 10-35% of patients experiencing radiation damage to the pelvic organs, bladder and rectum.
One of the promising ways of increasing the effectiveness of radiation treatment is to strengthen the damaging effects of radiation to the tumor with radiomodification agents, and the use of radioprotectors to protect normal organs and tissues.
As radiomodification drugs currently widely used 5-fluorouracil, simultaneously with cytotoxic properties. However, to achieve radiativeconvective drug required intravenous administration of relatively high doses of this drug, what often limited by the development of toxic manifestations.
There is a method of treating patients with locally advanced common forms of cervical cancer, including chemotherapy 5-fluorouracil for 5 days daily with subsequent simultaneous introduction of the platinum source of drug and radiation therapy according to the scheme of dynamic fractionation of the dose. Additionally injected gel "Collegel" Derinat once a day in the vaginal tube and at the same time as the micro into the rectum in the first 5 days of treatment, then 3-4 hours before or 1-2 hours after each session and after a course of radiation within 2-3 weeks continue instillation in the vaginal tube in the same volume (Patent RF №2393897, IPC A61K 31/513, publ. 2010).
The disadvantage of this method is the possibility of developing toxic effects of 5-fluorouracil with its infusion introduction (decreased number of white blood cells and thrombocytopenia), in addition platinum drugs have an increased toxicity, poorly tolerated by people in the older age group, so it is not always possible to undertake a full course of chemotherapy.
There is a method of treating patients with locally advanced common forms of cervical cancer, including external irradiation and the use of chemotherapy, United with autoplasma (Patent P is No. 2261706, IPC A61K 31/282, publ. 2005).
The disadvantage of this method should be considered as the use of plasma, requiring the intake of large amounts of blood, strict antiseptic and sterilization procedures, i.e. how complex in execution, in addition, only external irradiation cannot be considered an adequate method of treatment of locally advanced cervical cancer.
There is a method of treatment of locally advanced cancer of the uterine body (Patent RF №2243771, IPC A61K 31/513, publ. 2005), including the use of chemical drugs and intrauterine irradiation. On the first day of treatment interstitielle peritumoral administered cyclophosphamide, the second day into the uterine cavity on creamy basis injected fluorouracil or adriablastin, the next day, spend the session intracavitary irradiation, the course may be repeated three times with a 6-day break.
The disadvantage of this method is inefficient, especially when a large tumor volume, high probability of toxic manifestations, because it does not enter one drug, and the number of different drugs, such as cyclophosphamide, adriablastin, 5-fluorouracil.
The closest is a method of treating patients with locally common forms of uterine cancer, including remote and potrebonosti radiation therapy, chemotherapy (I. Stolyarova. Radiotherapy of advanced endometrial cancer with or without metrondazole as radiosensitizcr. Zerbinis Medical Publications. Printed in Greece. Journal of BUON 5: 411-414, 2000.). Cancer of uterine body got mixed beam therapy by alternating intracavitary and remote exposure. Before each session intracavitary irradiation in the uterine cavity was entered metronidazole (MZ), dissolved in dimethyl sulfoxide (DMSO). To obtain this solution 1-2 g of crystalline MOH was dissolved in 10 ml DMSO. The prepared solution was injected into the uterine cavity ex tempore.
The disadvantage of this method is that in the treatment of locally advanced tumours of the uterus actually there is no substrate for the action of metronidazole with as radiosensibility donor-Accenture properties, resulting in exposure due to undergoing radical processes generating active radicals, causing regression of tumors, for this area it is impossible to achieve the desired effect, since, as a rule, these tumor tissue well oksigenirovannym due to the development of pathological neovascularization.
The invention aims to remedy these disadvantages, increasing the effectiveness of treatment by increasing the rate of tumor regression, stabilization of the tumor process, prevention of postradiation complications without the risk of severe toxic manifestations of systemic nature, including the elderly against the TA with additional systemic diseases, not to be surgical procedure, and with large tumors, more than 120 cm3volume.
To solve the tasks performed intracavitary and external beam irradiation, chemotherapy. This proposed within 5-7 days before the start of radiotherapy sessions to introduce in the vaginal tube "Collegel-Beta 1, beta interleukin in a volume of 20 ml daily. Immediately before each session intracavitary irradiation in the uterus it is necessary to enter 5-fluorouracil on the media with high viscosity, namely gel "Collegel" with 5-fluorouracil in a volume of 20 ml to 25 ml (depending on the volume of the uterine cavity defined by ultrasound) with exposure time of 30-40 minutes. 40-50 minutes after a session of remote radiation to enter into the rectum and the bladder 20 ml of gel on the basis of sodium alginate containing methyluracil, dimethylsulfoxide (DMSO) and hydrocortisone in therapeutically effective amounts. Since the beginning of the course remote irradiation carried out 5-10 of these procedures.
The implementation of the method is demonstrated on specific clinical examples:
Patient S., 68, was in MCRT diagnosed with cancer of uterine body Art. III, hypertension Art. II, diabetes mellitus. In the clinical-laboratory examination revealed the distribution process at the parametrium, because h is th execution of surgical intervention was considered impossible. Tumor volume was 140 cm3. The only possible method of treatment was found chemoradiotherapy.
The patient was treated by the proposed method includes courses intracavitary and remote exposure. However before irradiation was carried out the application in the vaginal tube "Collegel-Beta 1, beta interleukin. The gel was injected daily with 20 ml within 7 days.
Immediately before each session intracavitary irradiation in the uterine cavity was injected 20 ml of "Collegel" with 5-fluorouracil, the duration of application was 40 minutes while she was on the gynecological chair.
The introduction of the drug into the uterus of the patient was transferred satisfactorily, side effects and complications associated with the drug, was not observed.
Subsequently the patient was transported to the canyon for holding intracavitary irradiation. The session was held at the AGAT-WU using metrostate 3-channel type. A single absorbed dose at point a was 5 Grams. Number of sessions - 10, with a frequency of 2 times per week. The total absorbed dose at point a was 50 Gy.
Then was appointed external beam radiation for LINAC-20 MeV to 4 Olney methods fields h see Single focal dose points was 2 Gy, and the total is 44 Grams. Were egene is but 10 sessions this exposure.
40 minutes after 1-5 sessions of remote exposure to the rectum and bladder were injected with 20 ml of gel on the basis of sodium alginate containing methyluracil, dimethylsulfoxide and hydrocortisone in a therapeutically effective amount, namely, in wt.%: methyluracil - 5, DMSO - 5 and hydrocortisone - 0,4.
As a result of therapy achieved initial clinical cure, which was recorded 7 days after the treatment. This indicates an increase in the rate of regression of the tumor of uterine body, which was confirmed by the data of cytomorphological studies of material from the uterine cavity, and ultrasound data. After 10 treatments intracavitary irradiation and 22 remote session therapy proposed course of treatment, tumor volume was significantly reduced by 50%, after treatment tumor volume was 75 see
It should be noted that similar results of treatment of patients with such amounts of destruction (140 cm3previously could not been reached.
During examination after 6 months found a stabilization process.
Patient P., aged 63, was in MCRT diagnosed with cervical cancer III In Art., 2-sided parametric variant, exophytic form of growth. Histologically, squamous non-squamous cancer. Tumor volume by ultrasonography was 180 cm in volume of 20 ml daily.
Were treated by the proposed method.
Similar to that described in Example 1 was performed application in the vaginal tube "Collegel-Beta 1, beta interleukin within 5 days prior to exposure.
Given the exophytic tumor shapes, holding intracavitary irradiation in the first stage was impossible.
Due to the above reasons, the irradiation was started with remote radiation therapy using open fields size h see a Single absorbed dose metering points (points a and b) was 2 Gy. The total dose to the pelvis was brought to 30 Gr. Conducted 15 sessions of exposure daily. After 1-10 sessions remote exposure 40-50 minutes was introduced into the rectum and the bladder 20 ml of gel on the basis of sodium alginate containing methyluracil, DMSO and hydrocortisone in therapeutically effective amounts (analogously to example 1).
The tumor was reduced to 135 cm3. Then the irradiation was continued in the form of intracavitary gamma-therapy, which was held at the AGAT-WU 1 time per week, only 7 procedures. Single focal dose at point a was 7 Grams. The total dose at point a - 49 Gr.
Immediately before each session intracavitary irradiation was introduced into the uterine cavity (given the size of the uterine cavity defined by ultrasonography) 25 ml of the gel, the number of the gel with 5-fluorouracil with an exposure time of 40 minutes.
As a result of therapy was achieved stabilization process. According to cytomorphological studies, tumor cells were detected after treatment. According to the ultrasound, after this first course of therapy there was a significant decrease in the size of the cervix and body of uterus (V tumor - 85 cm3), i.e. it was noted the increase in the rate of regression but compared to treatment by standard techniques similar degree of neoplastic processes. It should be noted that when such amounts defeat a similar result is achieved no more than 5-10% of cases.
Patient D., 72 years old, was hospitalized in MCRT diagnosed with cancer of uterine body Art. II Histologically - moderately differentiated adenocarcinoma of the endometrium. Tumor volume was 120 cm3. Given the presence of the patient severe comorbidity (hypertension III degree, the cerebral circulation from 01.2010,; diabetes mellitus type II, and expressed obesity) the method of choice was radiation therapy.
A complication of the underlying disease was the presence of pyometra. Treatment was started with the introduction in the vaginal tube "Collegel-Beta 1, beta interleukin but 25 ml daily for 5 days.
Before each session intracavitary irradiation in the uterus enter and 25 ml "Collegel" with 5-fluorouracil. The exposure time was 30 minutes, during which she was on the gynecological chair. The introduction of the drug into the uterus did not cause any complications. The session was held at the AGAT-WU. A single absorbed dose at point a was 5 Grams. Number of sessions - 10, with a frequency of 2 times per week. The total absorbed dose at point a was 50 Gy.
The second phase of radiation therapy was external beam radiation for LINAC-20 MeV, 3 times in Pedalo fields complex spatial configuration by summing the absorbed dose at points In - Gr 2;
the total absorbed dose at the point of account amounted 42-44 G, the number of procedures 5.
After each of the 5 sessions of remote exposure through 50 minutes into the bladder and rectum were injected with 20 ml of gel on the basis of sodium alginate containing methyluracil, DMSO and hydrocortisone. This allowed to undergo radiation treatment without any reactions and complications.
As a result of therapy was achieved initial clinical cure. This was confirmed by cytological and morphological studies of material from the uterine cavity, taken after the end of radiotherapy. V tumor was 65 cm3.
Integrated chemo-and radiotherapy patients aged over 60 years with locally widespread the United cancers of the uterus allows you to reach after the first course of treatment for primary clinical cure with reduced tumor volume by 40-50%, even in large volumes.
When using the proposed method increases the speed of the radial regression of malignant tumors of the cervix and uterine body (double time reduction of tumor volume 8±1 days; control 12±1 day), increases the survival rate of the patients with extensive tumors of the cervix and uterine body (2-year survival rate is 79%, in control - 47%). The method allows for effective prevention of the complications of radiation from the side adjacent to the uterus organs, resulting in reduced frequency and severity of radiation injury of the rectum (3,5% against 13.6% in the control) and bladder (3,5% against 7.7% in the control group), which improves the quality of life of patients and increases the effectiveness of the treatment.
A method of treating patients with locally common forms of uterine cancer, including remote and intracavitary radiation therapy, chemotherapy, characterized in that it is injected into the vaginal tube within 5-7 days before radiation "Collegel-Beta 1, beta interleukin in a volume of 20 ml daily, immediately before each session intracavitary radiation therapy exercise introduction into the uterine cavity "Collegel" with 5-fluorouracil in a volume of 20 ml to 25 ml with an exposure time of 30-40 minutes and after sessions remote exposure 40-50 minutes is introduced into the rectum and the bladder 20 ml of gel-based Algin is the sodium, containing methyluracil, dimethylsulfoxide and hydrocortisone in therapeutically effective amounts, with the start of the course for distance irradiation carried out 5-10 of such procedures.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to immunology. Described are antibodies against VEGF, one on which contains complementary regions with amino acid sequences SEQ ID NO:1, 2, 3, 4, 6 and 7, another contains complementary regions with amino acid sequences SEQ ID NO:1, 2, 3, 5, 6 and 7, disclosed in description. Also described are polynucleotides, coding said antibodies; espression vectors, containing said polynucleotides, and host cells, intended for obtaining antibodies in accordance with the claimed invention. Claimed is method of obtaining antibodies against VEGF, which includes expression of vector in host cell and separation of antibody. Disclosed is method of obtaining immunocongugate of antibody against VEGF, which includes conjugation of antibody with drug or cytotoxic agent. Described is method of VEGF identification, which includes identification of complex VEGF-antibody against VEGF in biological sample. In addition, described are compositions for treatment of VEGF-associated disease, one of which contains efficient quantity of antibody against VEGF, and another - efficient quantity of polynucleotide, coding said antibody. Also disclosed are methods of: 1) treating tumour, cancer or VEGF-associated cell proliferative disease; 2) inhibition if angiogenesis in subject and 3) inhibition of vascular permeability; consisting in introduction to subject of efficient quantity of antibody against VEGF in accordance with claimed invention.
EFFECT: invention makes it possible to obtain antibodies against VEGF and apply them for treatment of VEGF-associated diseases.
41 cl, 16 dwg, 2 tbl, 5 ex
SUBSTANCE: photosensitiser Photosense is administered. The patient is irradiated with using an optical fibre with a lens on a distal end in contact with a chest wall along intercostal spaces in 8-10 random positions for 1 therapeutic session. A light dose of one position of the laser radiation is 100 J, and an output power is 200-250 mWt,.
EFFECT: method provides regression of the tumoural process, obliteration of the pleural cavity without the aggressive intrapleural intervention, and eliminates potential infections.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medication for treatment or prevention of disease, which developed on the basis of structural and/or functional, and/or compositional changes of lipids in cell membranes, selected from cancer, vascular diseases, inflammatory diseases, metabolic diseases, obesity and excessive body weight, neurological or neurodegenerative disorders, which represents compound of formula COOR1-CHR2-(CH2)a-(CH=CH-CH2)b-(CH2)c-CH3 (I) or its pharmaceutically acceptable salts and derivatives, selected from esters, ethers, alkyl, acyl, phosphate, sulfate, ethyl, methyl or propyl; in which a and c can have independent values from 0 to 7; b can have independent values from 2 to 7, where R1 is selected from the following radicals: H, Na, K, CH3O, CH3-CH2O and OPO(O-CH2-CH3)2, and R2 is selected from the following radicals: OH, OCH3, O-CH3COOH, CH3, Cl, CH2OH, OPO(O-CH2-CH3)2, NOH, F, HCOO and N(OCH2CH3)2.Invention also relates to application of formula (I) compound and pharmaceutical composition, which contains it.
EFFECT: medications, based on claimed compound, are more efficient than medications of preceding level of technology.
22 cl, 7 dwg, 16 tbl, 10 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to methods for producing bacteriochlorines presented by formulas (I), (III), wherein the radical values X1-X8, R1-R8, Y, R' are specified in cl. 1, 2 of the patient claim, for a photodynamic therapy (PDT) of hyperproliferative tissues, such as tumours, hyperproliferative blood vessels and other PDT-responding diseases or anomalies.
EFFECT: higher effectiveness of the method.
2 cl, 22 dwg, 21 ex
SUBSTANCE: invention relates to compound of formula (I) or its pharmaceutically acceptable salt, where A stands for -CHR7-, where R7 represents hydrogen, C1-6 alkyl, optionally substituted with substituent, selected from -OH, -OR8, where R8 represents C1-6 alkyl, -NH2, -COOH and -CONH2, C6 aryl-C1 alkyl, optionally substituted with 1-3 substituents, selected from-OH, -OP(=O)(OH)2, -OP(=O)(ONa)2 and C1-6 alkyl, 5-9-member heteroaryl- C1 alkyl, C6 cycloalkyl-C1 alkyl, C6 aryl or C6 cycloalkyl; G stands for -NR6- or -O-, where R6 is independently selected from C1-6 alkyl and C2-6 alkenyl; R1 stands for -Ra-R10; where Ra stands for C1-6 alkylene and R10 represents naphthyl or 9-10-member bicyclic condensed heteroaryl, optionally substituted with substituent selected from -NH2 and halogen; R2 represents -W21-W22-Rb-R20, where W21 represents -(CO)-; W22 represents -O- or -NH-; Rb represents bond or C1-6 alkylene, optionally substituted with C1-6 alkyl; and R20 represents C1-6 alkyl, C6-10 aryl, optionally substituted woth halogen, 5-6-member heteroaryl or C6 cycloalkyl; and R3 represents C1-6 alkyl; where "heteroaryl" represents monocyclic or bicyclic aromatic radical, where 1-3 ring atoms are heteroatoms, selected from nitrogen, oxygen and sulphur, and remaining ring atoms are carbon atoms and "bicyclic condensed" means ring, bound with another ring with formation of bicyclic structure, when atoms, common for both rings, are directly bound to each other. Invention also relates to particular compounds, method of treating or preventing disorder, modulated by Wnt-signaling pathway, agent, based on (I) formula compound, intermediate compound of formula (II) , method of obtaining formula (I) compound.
EFFECT: obtained are compounds, represented by formula (I), which possess useful biological properties.
32 cl, 3 dwg, 2 tbl, 209 ex
SUBSTANCE: invention relates to a method for synthesis of chelator-targeting ligand conjugates, which can be used to treat and diagnose diseases, e.g., by imaging tumours or myocardial ischaemia. The method includes step (a) for conjugating, in an organic medium, a chelator of formula with at least one unprotected targeting ligand, which is glucosamine, where each of A and D is a protected thiol, each of B and C is a protected secondary amine; each of E and F is a -COOH group; each of R1, R2, R3 and R4 is H; X denotes -CH2-CH2-; and where conjugation occurs through formation of an amide bond between E or F of the chelator and the amino group of the glucosamine. The organic medium used is usually a polar or nonpolar solvent or a mixture thereof. The method can further include (b) purifying the conjugate of the chelator-targeting ligand; step (c) of chelating a metal ion with the conjugate of the chelator-targeting ligand to form a metal ion-labelled chelator-targeting ligand conjugate. Step (c) includes a step (d) of removing at least one protective group from the metal ion-labelled chelator-targeting ligand conjugate or additionally a step (e) of adding a reducing agent. The preferred conjugates are 99mTc- ethylenedicysteine (EC)-glucosamine, 188Re-EC-glucosamine or 187Re-EC-glucosamine.
EFFECT: method enables to products of high purity.
10 cl, 13 dwg, 4 tbl, 18 ex
SUBSTANCE: present group of inventions relates to biotechnology. What is presented is a humanised anti-CD79b antibody and its antigen-binding fragment produced of murine antibody MA79b and CD79b having a substantially analogous binding affinity thereto. A polynucleotide, a vector, a host cell and a method for producing the anti-CD79b antibody according to the invention; immunoconjugates, compositions and methods for cell growth inhibition, a method of treating an individual suffering cancer, a method of treating a proliferative disease and tumour in a mammal, a method for B-cell proliferation inhibition; a method for detecting the presence of CD79b in a sample and method for binding the antibody to the CD79b expressing cell are also disclosed.
EFFECT: given invention can find further application in therapy of the CD79b associated diseases.
86 cl, 20 tbl, 9 ex, 51 dwg
SUBSTANCE: invention refers to genetic engineering, more specifically to analysing the disorders related to ovarian carcinoma, and may be used in medicine. The method involves determining the methylation status of CpG-dinucleotide in the genome in each sequence of a group of sequences SEQ ID NO:1-10 using a set of probes specific for the above sequences and able to be hybridised with the sequence along the full length. The above sequences are used as a part of a chip for detection, diagnosis and monitoring of the proliferative disorders related to ovarian cell proliferation, as well as for detection of a predisposition to the proliferative disorders, or treatment of the proliferative ovarian disorders.
EFFECT: invention enables identifying the proliferative disorders in ovarian cells and detecting a genetic predisposition to the above disorders.
10 cl, 3 dwg, 2 tbl, 1 ex
SUBSTANCE: compound of formula (I) is obtained by carrying out the following steps: reacting 2-(2,4-dimethoxyphenyl)-3-(2-nitrobenzene suphenyl)-4(S)-phenyl-5(R)-oxazolidene carboxylic acid with 10-deacetyl-bis-7,10-trichloroacetyl baccatin III to obtain 10-deacetyl-7,10-bis-trichloroacetyl baccatin(III)-13-yl ether of 2-(2,4-dimethoxyphenyl)-3-(2-nitrophenzol sulphenyl)-4(S)-phenyl-5(R)-oxazolidine carboxylic acid (VII). Trichloroacetyl groups in positions 7 and 10 of the compound of formula (VII) then undergo hydrolysis to obtain 10-deacetylbaccatin(III)-13-yl ether of 2-(2,4-dimethoxyphenyl)-3-(2-nitrobenzene sulphenyl)-4(S)-phenyl-5(R)-oxazolidine carboxylic acid (VIII). At the last step, the compound of formula (VIII) is treated with acid to obtain 10-deacetyl-N-debenzoyl paclitaxel (I).
EFFECT: improved method of producing docetaxel with high degree of purity.
3 cl, 2 dwg, 6 ex
SUBSTANCE: invention relates to a co-crystalline form of bicalutamide with 2-hydroxybenzamide with molar ratio of 1:1. The co-crystalline form has: an endothermic peak from 156°C to 160°C based on measurement data through differential scanning calorimetry (DSC analysis), peaks at 2θ(°) 3.16, 4.94, 5.66, 26.1 based on measuring X-ray diffraction of the monocrystal.
EFFECT: obtaining a novel co-crystalline form of bicalutamide with a high rate and level of solubility, which can be used as a pharmaceutical preparation for treating prostate cancer.
5 cl, 7 dwg, 2 ex
SUBSTANCE: invention refers to medical equipment, namely to radiotherapeutic methods and systems. A radiotherapeutic method consists in ionising radiation pulse beam injection into an object for a pulse interval, obtaining a sampled data array of magnetic-resonant visualisation and restoring the data array with MR image formation. The sampled data array is obtained for an interval of sampled MR data longer than pulse intervals, with the sampled interval overlapping some of the pulse intervals. The data array is restored without the changed sampled MR-visualisation data obtained within the time periods of obtaining the data overlapped by the pulse intervals. The system comprises a radiotherapeutic subsystem, a MR-visualisation subsystem, a synchro unit and a restoring processor.
EFFECT: using the invention enables reducing the time of the radiotherapeutic session.
16 cl, 3 dwg
SUBSTANCE: invention refers to medicine. A magazine comprises a body and a first instrument receiving the chain units and rotating in the body and having a socket or a hollow for receiving the chain units, as well as an extension spring for controlling the instrument receiving the chain units, a toothed gear fastened to the instrument receiving the chain units and rotating in the body, and an ejection unit comprising an ejection opening for ejecting radioactive emitters, and an ejection lever rotating in the body; the ejection lever is configured so that in the first position it links up with the toothed gear, and in the second position it blocks the ejection. In the above system, a further rotation of the instrument receiving the chain units after the chain unit ejection is blocked by an interaction of the chain unit following the chain unit that has been ejected, and the ejection lever.
EFFECT: patient's optimum protection against radioactive emission is provided.
15 cl, 22 dwg
SUBSTANCE: invention refers to medicine, oncology, therapy of patients suffering lung cancer and having contraindications to the surgical management. There are prescribed autohemochemotherapy (AHCT) that is administering chemopreparations incubated with autoblood, and radiation therapy (RT). Pre-therapeutic blood prolactin and progesterone are measured, and before the beginning of the AHCT, the patient starts taking bromocriptine 2.5 mg once a day with food; besides, oxyprogesterone capronate 1 ml is administered intramuscularly twice a week every 3 days. That is followed by the AHCT course consisting of 1-3 administrations of autoblood CP, and if observing a complete tumour resorption, the surgical management to the extent of pneumoectomy is supposed to follow, while a partial resorption observed two weeks after the last auroblood CP administered, implies the RT: at first 2 Gy twice a day every 4-5 hours starting from 5 days a week to achieve a basic dose of 28 Gy. That is followed by a 2-week pause, then 4 Gy daily, 3 radiation fractions a week, 6 fractions in total, up to a total radiation dose of 52 Gy for the whole RT course. Throughout the treatment, the patient keeps taking bromocriptine and oxyprogesterone capronate with controlling the blood prolactin and progesterone values: as compared to the pre-therapeutic values, prolactin is expected to fall to the end of the treatments, while progesterone - to rise.
EFFECT: method provides improving the conservative therapeutic effect in the patients of the given group: downsizing the tumour and lymph nodes until the primary tumour regresses completely by 30%, and the patients change to the resectable state; improving the patient's quality of life.
2 ex, 1 tbl
SUBSTANCE: invention refers to medical equipment, namely to devices for beam teletherapy. A collimator comprises a body with a base, a cover and side plates wherein the base is parallel with two assemblies of lamination stacks at the same height each of which is movable by an individual drive parallel with the base and perpendicular to an axis of symmetry of the collimator. The drives are individual for each of the lamination stacks and coupled with the most distant end faced from a geometric axis of the collimator through individual screw gears. The lamination stacks have the same thickness, lateral "П"-profile and integrated into an assembly. The lower lamination stacks of the assemblies have a convex-convex "П"-profile, while internal surfaces of the base and cover have cavities for profile projections of the respective lamination stacks. Each end face involved in beam aperture formation represents alternating "П"-projections and slots with the projections and slots of the lamination stack of one assembly match, while those of the other lamination stack are staggered in relation thereof.
EFFECT: using the invention provides higher rate and accuracy of the pre-set beam aperture formation.
7 cl, 7 dwg
SUBSTANCE: invention refers to medicine, particularly ophthalmology, and may be used for treating corneal ulcer. That is ensured by the integrated treatment including the intake of Lymphomyosot 10 drops in 50-100 ml of water three times a day for three weeks; Traumel 1 tablet 3 times daily for three weeks sublingually; 10 subcutaneous 2.2 ml injections twice a week: Mucosa Compositum, Solidago Compositum, Coenzyme Compositum; 10 subcutaneous 2.2 ml injections of Traumeel every second day; eye instillations of Oculoheel, okulohelya, Mydriacyl and colloidal silver 2 drops 3 times a day for 10 days; sea buckthorn oil under the eyelid 3 times a day for 10 days; Solcoseryl ointment or gel in the conjunctival cavity until observing the complete epithelialisation, and also the radiotherapy course from the first day of treatment in a dose of 50 cGy daily, within 5 sessions. The severe corneal opacities require the additional 5 sessions of the repeated radiotherapy course in a dose of 500 cGy daily following the 5-session radiotherapy course in a dose of 50 cGy three months later.
EFFECT: method enables increasing or recovering the visual acuity ensured by ulcer epithelisation with no side effects.
SUBSTANCE: invention refers to medical equipment, namely to localisation facilities for therapeutic sources. The device comprises an applicator implanted into a target area and having at least one guide passage for a radiation source or seed, a number of image-visible support points comprising a number of electromagnetic sensors with the support points being attached to a patient's body and adjoining the target area; what is also provided is an electromagnetic tracking system for localising the electromagnetic sensors on the support points; the device is equipped with a processor to form a brachytherapy session program on the basis of a combination of a relative position of the electromagnetic sensors on the applicator and the electromagnetic sensors on the support points, and images are also presented. According to the second version, the device also comprises a field generator with a number of the electromagnetic sensors for position indication signalling responding to the field generator. One of the electromagnetic sensors is placed on the applicator, and another one - on the target. The device comprises a number of processors for localising the source and target in response to the signals of the electromagnetic sensors.
EFFECT: using the invention enables more accurate planning with reduced radiation load.
14 cl, 3 dwg
SUBSTANCE: invention refers to medical equipment, and may be used in hadron radiation therapy of malignant tumours. The method comprises performing the pre-radiation preparation that is patient's body fixation, determination of the malignancy topographometry, development of a conformal irradiation schedule. A conformal irradiation session involves controlling a dose taken by a malignancy, admissible values of the radiation source, radioactivity, temperature of various segments of the radiation source and magneto-optic chains of beam delivery to the malignant tumour. During the pre-radiation preparation and conformal irradiation session, the patient is fixed in an identical adjusted position, the topographometry of the malignant tumours are evaluated, and a hadron beam is delivered to the patient' malignant tumour during an identical respiratory pause in the absence of a cardiac beat pulse wave peak with a constant size of a thorax.
EFFECT: use of the invention allows more precise irradiation of the pancreatic malignancies during respiration not injuring the healthy pancreatic tissues, as well as adjacent tissues and organs.
SUBSTANCE: invention refers to medicine, more specifically to oncology and radiology. The method involves the local radiation therapy sessions in a dynamic dose fractionation mode. Additionally, 3 times a week the local radiation therapy session is immediately followed by subtotal irradiation of the upper body from a suprasternal notch to a diaphragm. Thereafter, 21-28 days after the local radiation therapy completed, min. 4 cycles of the chemotherapy with each cycle combined with subtotal irradiation of the upper body from the suprasternal notch to the diaphragm 3 times a week.
EFFECT: method enables reducing a risk of developing a local recurrence of the tumour and metastases to 10,7% as compared to the previously known methods (15%), as well as a severity of complications with achieving the complete objective response to the treatment in 35,7% of the patients, and the partial response - in 46,42%.
SUBSTANCE: invention refers to medicine, oncology, pulmonology, radiology, radiation therapy of non-small-cell lung cancer. Sessions of the local radiation therapy are daily to a total focal dose equivalent to 60-70 Gy, in a dynamic dose fractionation mode at a single focal dose of 4-2 Gy. Additionally, three times a week immediately after the local radiotherapy session, an upper part of substernal notch to diaphragmare exposed to subtotal irradiation at a single dose of 0.1 Gy to a total dose of 1 Gy.
EFFECT: method provides reducing a risk of local recurrence, distant metastasis, and a severity of acute radiation reactions and injuries, eg pneumonitis, esophagitis, reducing the hematopoietic complications, complete tumour regression in 15,6% of patients with an average life expectancy of 18 months.
SUBSTANCE: invention relates to medicine, in particular to ophthalmology and endocrinology, and can be used for treatment of endocrine ophthalmopathy. For this purpose introduced are: galium heel is introduced in dose 10 drops in 50-100 ml of water 3 times per day, for 3 weeks, reneel in dose 1 tablet sublingually 3 times per day for 3 weeks, injections of cerebrum compositum under skin in dose 2.2 ml 2 times per week, with 3-day interval, 5 injections in total, starting from the first day of treatment, injections of coenzyme compositum under skin in dose 2.2 ml 2 times per week, with 3-day interval, 5 injections in total, as well as hirudotherapy 2-3 leeches on temporal area, starting from the first day of treatment, two times per week, 4-6 procedures in total, with 3-day interval, radiotherapy, starting from the first day of treatment, by means of beta-applicators on projection of thickened muscles with radionuclide Ruthenium-106+ Rhodium 106, 5 sessions, 200 cGy each, daily.
EFFECT: method makes it possible to increase efficiency of treatment of endocrine ophthalmopathy due to reduction of edema of retrobulbar tissue and extraocular muscles with the lowest number of side effects and improvement of parameters of blood of thyroid gland hormones.
SUBSTANCE: invention refers to medicine, namely to traumatology and biotechnology, and may be used for the biocompatible polymeric structure formation in bone tissues. That is provided by a puncture approach to a filled cavity in the bone tissues. That is followed by filling the cavity with a polymeric gel compound containing 55-97.7 wt % of the biocompatible polymer polylactide of a particle size of 50 to 100 mcm, 0.3-45 wt % of magnetic nanoparticles of ferric oxide of a particle size of 10 to 100 nm, the gelling agent maltodexrin in the amount of 0.5 to 50 wt % of the weight of mixed polymer and magnetic nanoparticles, as well as distilled water in the amount of 0.5 to 100 wt % of the weight of a dry mixture of the polymer, magnetic nanoparticles and gelling agent. A solid three-dimension structure is formed. That is accompanied with heating the compound throughout by exposing to an alternating magnetic field at frequency 500 kHz and amplitude 500 E for 3-5 minutes. Where appropriate slow down the process of heating the compound, it is additionally exposed to a direct magnetic field at amplitude 1000 E applied either to the whole formed volume, or locally depending on the problem to be solved.
EFFECT: method enables forming the biocompatible three-dimension structure in the specified cavity of the bone tissue with minimum surgical intervention.