Synergistic combination of glyphosate and thiabendazole

FIELD: medicine.

SUBSTANCE: synergistic antimicrobial composition contains a zinc salt of glyphosate and thiabendazole, wherein the weight ratio of thiabendazole to the zinc salt of glyphosate is from 0.1:1 to 10:1. A method of inhibiting the growth or controlling the growth of microorganisms in a construction material involves the step of adding the synergistic antimicrobial composition. A coating composition comprises the given synergistic antimicrobial composition. A dry film is made by a process comprising applying a layer of the synergistic composition to a substrate and drying.

EFFECT: controlling the growth of microorganisms, fungi, algae on the finish surfaces of the construction materials.

6 cl

 

The present invention offers a combination of biocides, which are characterized by unexpectedly higher activity compared with the use of both individual antimicrobial compounds.

The use of combinations of at least two antimicrobial compounds can expand the potential markets, to reduce the working concentration and cost, and reduce waste. In some cases, commercial antimicrobial compounds do not effectively control the growth of microorganisms, even at high working concentration due to their low activity against certain types of microorganisms, for example, microorganisms that are resistant to certain antimicrobial compounds. A combination of different antimicrobial compounds in some cases are used to provide overall control growth of microorganisms in a particular environment. For example, in the application WO 1998/121962 described the combination of 3-iodine-2-propynylbutylcarbamate and pyrithione zinc, but in this application are not expected to use any of the combinations claimed in the present invention. Moreover, there is a need for additional combinations of antimicrobial compounds that have relatively low impact on the health and/or the environment. The aim of the present invention is the development that accounts for what these additional combinations of antimicrobial compounds.

In some cases, antimicrobial compounds include liquid compositions for coatings, which are applied to the substrate, and turning into a dry film. It is necessary that such dry film provided level control of algae and fungi on the surface and had minimal adverse effects on health and the environment.

Below is a description of the essence of the present invention.

The first object of the present invention offers a synergistic antimicrobial composition comprising glyphosate and thiabendazol (TBS). The second object of the present invention proposes a method of inhibiting the growth of or controlling the growth of microorganisms in the construction material adding a synergistic antimicrobial composition according to the first object of the present invention. The third object of the present invention features a composition for coating containing a synergistic antimicrobial composition according to the first object of the present invention.

The fourth object of the present invention offers a dry film obtained from the composition for coating according to a third object of the present invention.

Below is a detailed description of the invention.

In this context, used the following terms, definitions are given below, if the e specified otherwise.

The term "antimicrobial compound" means a compound capable to inhibit the growth of or controlling the growth of microorganisms, antimicrobial compounds include bactericidal, bacteriostatic, fungicidal, fungistatic, algaecide and legistations drugs depending on the magnitude of the dosage used, the condition of the system and the required level control of microorganisms. The term "microorganism" includes, for example, fungi (such as yeast and mold), bacteria, and algae. In the description of the invention uses the following abbreviations: ppm million - mass part per million, ATSS American type culture collection and MIC - minimum inhibitory concentration. Unless otherwise stated, values are expressed in weight percents (wt.%). The percentage of antimicrobial compounds in the compositions of the present invention are defined in the calculation on the total weight of the active ingredients in the composition, i.e. themselves, antimicrobial compounds, excluding any quantities of solvents, carriers, dispersing agents, stabilizers, or other materials that may be present.

Used in this context, the term "TBS" means thiabendazol. If in this context indicates that the ratio is X:1 or more, this indicates that the ratio is equal to Y:1, where Y is equal to X Il is more and if in this context indicates that the ratio is X:1 or less", it means that the ratio is equal to Z 1, where Z is equal to X or less.

Glyphosate refers to N-(phosphonomethyl)glycine (registration number 1071-83-6). Glyphosate is a known herbicide, which has been approved in many organizations for use in the control of weeds in crops food crops. It was found that one of the estimates is relatively low impact of glyphosate on the environment is its relatively low activity against various weeds. Some results characterizing the activity of glyphosate against various algae, is presented below:

Evaluation activity(1)Algae72 h96 hDay 7
EbWith50green algae (Selenastrum capricornutum)485 mg/lto 13.8 mg/l
The EGU50green algae (Selenastrum capricornutum)460 mg/l
EU50marine algae (Skeletonema costatum)1.3 mg/l0.64 mg/l
EU50diatoms (Navicula pelliculosa)42 mg/l
EU50blue-green algae (Anabaena flos-aquae)15 mg/l
(1)Notes.

EUn/EU50. The effective concentration ECndenotes the concentration at which a specified period of time the compound has an effect on n% of the population. The EC50widely used, since it represents the most accurate reference point on the curve steps from concentration.

EtbC50denotes the average effective concentration in terms of biomass (algae): the concentration at which a specified period of time, the increase in biomass is reduced by 50% compared with the control sample.

ErWith50denotes the average effective concentration against karasti growth (algae): the concentration, when in a given period of time, the rate of growth of algae cells is reduced by 50% compared with the control sample.

The above data indicate a relatively low influence of glyphosate on algae, indicating a relatively low effect of glyphosate on the environment. The above description is considered to be suitable for antimicrobial material that can be included in the composition for cover.

In the present invention proposes the use of glyphosate. Used in this context, the term "glyphosate" refers to glyphosate or salt of glyphosate. Salt of glyphosate denotes a salt of glyphosate and metal. Suitable metals include alkali metals, alkaline earth metals and transition metals. Salts of glyphosate are preferred compared to glyphosate. More preferred are salts of glyphosate and transition metals, the most preferred zinc salt of glyphosate.

Glyphosate is characterized by a relatively high solubility in water. Indicated relatively high solubility in water is not preferred for antimicrobial material that can be included in the composition for coating or other building material, as dry coatings and building materials exposed to water, which the traveler can wash the connection, high solubility of the dry coating or building material. Preferred are salts of glyphosate, the solubility of which in water at 20°C is 3 g/l or less, more preferably 1 g/l or less, most preferably 0.3 g/l or less.

We can assume that salt of glyphosate have relatively low impact on health and the environment, as it is assumed that the action of salts of glyphosate on human health and the environment similar to the action of glyphosate.

The present invention features a composition that includes glyphosate and TBS. Unexpectedly, it was found that this composition is characterized by the synergistic action as an effective biocide. First of all, it has been unexpectedly found that compositions that contain zinc salt of glyphosate and TBS, characterized by the synergistic action and as an effective biocide.

The preferred mass ratio TBS/glyphosate is from 0.1:1 to 10:1. In one preferred embodiment, the mass ratio TBS/glyphosate is from 0.1:1 to 1:1. In another preferred embodiment, the mass ratio TBS/glyphosate ranges from 1:1 to 10:1.

The mixture of glyphosate and TBS can be included in the composition for coating. Glyphosate and TBS can be added to the composition for coating in which eljnosti or in the form of a mixture or any combination of these compounds. Preferred compositions for coatings are liquid. Compositions for coatings are water or no water. Aqueous compositions for coatings containing 40 wt.% or more of water based on the weight of the composition for cover.

Among the embodiments of the present invention, in which glyphosate and TBS included in the paint composition or a different composition for coating, the preferred compositions for coatings are liquid compositions, especially compositions which contain dispersions of polymers in aqueous media.

In addition to inks and other compositions for coatings, combinations of biocides of the present invention is primarily suitable for the conservation of building materials, for example, adhesives, sealant, seam sealant, insulation, upholstery cardboard and the like, polymers, plastics, synthetic and natural rubber, paper products, fiberglass, insulation, exterior insulation systems, roofing material and construction of cardboard, plaster, brick, mortar, plasterboard, timber and wood-plastic composite materials. If the combination of biocides of the present invention is present in the building material, preferably some combination or all combination of biocides were on the surface of the construction material ricottone close to the surface of the construction material, to suppress the growth of microorganisms on a given surface.

In some embodiments, use latex paint or other liquid compositions for coatings that contain combinations of biocides described in this context.

Compositions for coatings are designed for easy application of a layer of the composition for coating on a substrate and then drying or curing in air for drying, forming a dry film. Compositions for coatings contain a binder. Binders contain one or more of the following compounds: one or more polymers, one or more oligomers and/or one or more monomers. Oligomers and monomers in the binder composition intended for the polymerization and/or crosslinking during formation or after formation of the dry film. The polymers in the composition of the binder is not necessarily intended for stitching in the formation or after formation of the dry film.

Compositions for coatings optionally contain one or more dyes. The colorant is an inorganic or organic compound in the form of small solid particles. Dyes provide full or partial opacity of the dry film.

Combinations of suitable biocides for preservation of the dry film coating obtained after application of paint or other liquid compositions for covered who I am. Preferably the antimicrobial composition is an aqueous latex containing one or more combinations of biocides described in this context, or dry film coating, obtained by applying the paint to the surface. Water latex paint is a liquid aqueous composition for coating in which the binder polymer is in the form of a latex (i.e. in the form dispersed in water polymer particles). Preferred aqueous latex paint in which the binder contains one or more acrylic polymers.

Typically, the number of combinations of biocides of the present invention, providing control of microbial growth, is from 100 ppm million to 10000 ppm million of active ingredient. Preferably the amount of active ingredients in the composition is at least 300 ppm million, preferably at least 500 ppm million, preferably at least 600 ppm million, preferably at least 700 ppm million Preferably the amount of active ingredients in the composition is not more than 8000 ppm million, preferably not more than 6000 frequent./million, preferably not more than 5000 ppm million, preferably not more than 4000 ppm million, preferably not more than 3000 ppm million, preferably not more than 2500 ppm million, preferably not more than 2000 ppm mn, CR is doctitle not more than 1800 ppm million, preferably not more than 1600 ppm million above the concentration specified for liquid compositions comprising combinations of biocides, the content of biocides in dry film coatings is a higher value.

In the present invention it is also proposed a method of preventing microbial growth in building materials, especially in the dry film coatings, when included in the composition of the materials of any of the claimed combinations of biocides.

Typically, the antimicrobial composition is used to inhibit the growth of algae and/or fungi.

The composition according to the present invention includes glyphosate and TBS. It is assumed that in some embodiments, the composition includes one or more additional antimicrobial compounds.

It is assumed that the zinc salt of glyphosate is characterized by unexpected synergistic antimicrobial activity compared with the results expected for the combination of zinc and glifosato acid.

Below are examples of the implementation of the present invention.

Zinc salt of glyphosate was prepared as follows.

First pre-prepared reagents. Glifosato acid (15-20 g) was dried in a drying Cabinet at 80°C-90°C during the night. Prepared 1 M solution of NaOH in deionized water.

The solution of glyphosate were prepared following about the time. Deionized water (200 ml) measured in the beaker 600 ml containing magnetic Mielnik. Glifosato acid (15 g) was slowly added to a glass of water while stirring on the magnetic stirrer at moderate speed. For dissolution of glyphosate temperature was raised to 60°C-70°C, the temperature was monitored with a thermometer. the pH is brought to 6.0 by adding 1 M NaOH solution. Glyphosate was dissolved when the pH value is approximately 2.4. The mixture was stirred for 5-10 minutes

The solution of the zinc salt was prepared as follows. Deionized water (100 ml) measured in the beaker with a volume of 400 ml, containing magnetic Mielnik. Zinc chloride (36,25 g, chemically pure, ≥98%, of the firm Sigma-Aldrich, catalog number 208086) was weighed and was slowly added to the water in a measuring Cup with stirring on a magnetic stirrer. The solution was heated to 65°C.

The solution of the zinc salt of glyphosate prepared as follows. A solution of zinc chloride was added to a solution of glyphosate using a Pasteur pipette (9 inches). After each addition of a small amount of a solution of zinc chloride in the solution of glyphosate before adding the next portion of the solution of zinc chloride precipitate was dissolved. When the precipitate did not dissolve, the pH was brought to 5. The remaining solution of zinc chloride was poured into the solution of glyphosate, and the mixture was stirred overnight.

<> Note: the control of pH is extremely important to obtain the desired product. Upon receipt of the reagents described in this context, it is necessary to ensure that the pH value does not exceed 5.

Zinc salt of glyphosate was filtered as follows.

Collecting device for filtering comprising a Buechner funnel and flask Bunsen, United through the seal and is connected to a water-jet pump. The funnel was placed a filter paper (No. 41 Whatman companyTM). To create a vacuum included pump and filter paper were filled with deionized water. Suspension zinc salt of glyphosate was slowly poured on filter paper and then washed once hot (about 50°C) deionized water and twice with isopropyl alcohol.

The final solution of the zinc salt of glyphosate prepared as follows.

The filter paper containing the precipitate of zinc salt of glyphosate, were removed and placed in a large bowl of percenage glass. The Cup was covered with a metal foil and the foil is pierced with several holes for ventilation. The precipitate was dried in a drying Cabinet at 80°C-90°C during the night. Then the sediment was weighed into a clean pre-weighed glass vial with a label and record the mass of sediment.

Samples for the determination of anti-microbial the activity was prepared as follows.

One biocide, or a mixture of biocides were added white acrylic latex paint that does not contain biocides, to receive the maximum total concentration of the investigated active ingredient/ingredients. Then the specified paint was diluted acrylic latex paint that does not contain biocides, to receive required for analysis of concentration. The total concentration of biocides changed depending on the type of the investigated mixtures of biocides in the range from 400 ppm million up to 3300 ppm million After adding or dilution of biocides, each sample was mixed by hand for at least 1 min to form a homogeneous mixture. Each of the samples of paint, as control sample (not containing biocides)was used to obtain films on the black plastic panels of a copolymer of vinyl chloride and vinyl acetate (the Leneta company, Mahwah, NJ) using angular applicator (0,0762 mm, 3 mil). The panel carefully dried for at least 2 days, avoiding direct sunlight. From each panel cut out square disks (0.5 inch2, 1.27 cm2) and was used as substrate to determine the efficacy against fungi and algae. The specified size of the sample is allowed to surround the study disk agar by placing the disk sample in the hole analytical tablet. The analysis of each is brazza conducted in two iterations.

The analysis was performed under the following conditions.

To support the growth of microorganisms used in the appropriate environment (Bold's 3N for Chlorophyta, BG-11 for cyanobacteria and PDA for fungi). The investigated plates kept at room temperature (25°C-26°C) using the light / dark cycle for four weeks for algae. Records for the test fungi was kept at 30°C for four weeks. After completion of the incubation period was determined by the sample surface covered with visible gains microorganisms, in percent.

Seed algae

OrganismsAbbreviated nameTypeEnvironment analysis
Gloeocapsa sp.GsATCC 29159Unicellular, colony-forming cyanobacteriaBG-11
Oscillatoria sp.OsATCC 29135Filamentous cyanobacteriaBG-11
Nostoc communeNc CCAP 1453/29Unicellular, Chlorophyta CenobialBold
Trentepohlia aurea + Trentepohlia odorataTa + ToUTEX LB 429 + CCAP 483/4Filiform ChlorophytaBold
Chlorella sp. UTEX + Chlorella kessleriCs + CkATCC 30582 + ATCC 11468Unicellular chlorophyteBold
Calothrix parientinaCpUTEX LB 1952Filamentous cyanobacteriaBold

Seed fungi

OrganismsAbbreviated nameNo. ATCCMedia for cultivation and analysis
Aspergillus nigerAn9642PDA
Penicillium funiculosumPf11797PDA
Cladosporium herbarum Ch11281PDA
Aureobasidium pullulansAp9348PDA
Trichoderma viridetv32630PDA
Alternaria alternataAa20084PDA

Determination of the effectiveness against algae was carried out as follows (modified method ASTM 5589).

Method ASTM 5589 is a standard accelerated method of analysis to determine the resistance of different coatings (including paints) damage to the algae. For performance analysis the sample size was reduced from Petri dishes to 6-well plates. One sample was placed with sterile forceps into the center of the agar layer (on the surface) painted side up. Seed algae were obtained by mixing equal concentrations (approximately 1×10 CFU/ml) and equal volumes (depending on the number of samples, intended for planting) organisms with similar growth conditions.

In the study of synergism as inoculum for analysis received three mixed pool algae: a mixture of cyano is acteri Gloeocapsa sp. Oscillatoria sp., cultivated in the medium BG-11, single-celled Chlorophyta - Chlorella sp., Chlorella kessleri and Nostoc commune, which was mixed and cultured in medium Bold, filamentous algae Trentepohlia aurea, Tretepohlia odorata and Calotrix parientina, which were mixed and cultured in medium Bold.

To each well containing the sample, contributed seed, 400 μl of a mixture of organisms (approximately 1×10 CFU/ml), providing uniform coverage of the entire surface (layer of paint and the surrounding agar) seeds. The tablets are kept at room temperature (25°C-26°C) using cycles of light (model OTT-Lite No. OTL4012P, 40 W, 26 kilolumen (KLM)) and dark for four weeks. At the end of each week was determined by the total covered area in percentage increments of 5%.

Determination of the effectiveness against fungi was carried out as follows (modified method ASTM 5590).

Method ASTM 5590 is a standard accelerated method of analysis to determine the resistance of different coatings (including paints) to damage by fungi. For performance analysis the sample size was reduced from Petri dishes to 6-well plates. For analysis at the bottom of each well of a sterile 6-hole tablet was placed a layer of agar. One sample was placed with sterile forceps into the center of the agar layer (on the surface) painted side up. Posebno the material of fungi were obtained by mixing equal concentrations (approximately 1×10 CFU/ml) and equal volumes (depending on the number of samples for analysis), organisms with similar growth conditions. In the study of synergism as inoculum for analysis received three pool mixed mushrooms. Cladosporium herbarum was mixed with Trichoderma viride, Aspergillus niger was mixed with Penicillium funiculosum, a Alternaria alternata was mixed with Aureobasidium pullulans. To each well was made seed, 400 μl of a mixture of organisms (approximately 1×106CFU/ml), so that the entire surface (layer of paint and the surrounding agar) was uniformly coated seeds. The tablets are kept at a temperature of 30°C in the presence of moisture within four weeks. At the end of each week was determined by the total covered area in percentage increments of 5%.

The synergy index (IP) was calculated as follows.

IP was calculated by the method described in the article Kull F.C. and others, Applied Microbiology, so 9 (1961). In this study the IP was calculated by the formula below, and the minimum inhibitory concentration was determined by the inhibition (in %)that were recorded for individual biocide in respect of each of the investigated organism.

HC=Qa/QA+Q/QB

Qa refers to the concentration of biocide And mixtures

QA refers to the concentration of biocide And as the sole biocide

Q denotes the concentration of biocide In the mix

QB denotes the concentration of biocide In as the sole biocide

In this formula the value of IP<1 indicates synergy the m mixed biocides.

Note. If any active connection when the maximum investigated concentrations showed no overwhelming effect, this maximum concentration was used to calculate the estimated IP, and the sign "less than" ( < ) indicates that to achieve the desired level of suppression required a higher concentration of active compounds.

"OK" indicates the absence of the final values of the investigated concentrations, which satisfies the criterion of the percentage of suppression, prescribed for the calculation of each IP.

Listed below are compositions that include a zinc salt of glyphosate and TBS presented as examples of implementing the present invention. Other compositions are presented for comparison.

The results of the analysis of the zinc salt of glyphosate and glifosato acid is shown below.

tr>
Conc.Inhibition (%) against various studied organisms
Active connectionpart./millionCs+Ck+NcCp+To+Tags+osAA+ArAn+PfTv+Ch
Zinc salt of glyphosate750100015402050
1500100072,547,527,575
2500100090703090
Glifosato acid75037,50157,502,5
1500601072,520550
250080 7,59067,51072,5
Control sample000000

The results of the analysis of the compositions of the zinc salt of glyphosate and TBS below.

Suppression, %
RatioAn-PfAp-ChAa-TvOs-GlCh-NoCal-The
Zinc salt of glyphosate/TBS, 1:1
Total concentration, part./million4138253300413413413
Suppression, %70100 80100100100
IP0,340,50<1,000,630,580,63
Zinc salt of glyphosate/CBS, 3:1
Total concentration, part./million41233003300412412412
Suppression, %7060401008080
IP0,422,00<1,000,370,790,81
Zinc salt of glyphosate/TBS, 5:1
Total concentration, part./million16503300825825825825
Suppression, %90809010080100
IP1,782,00<0,250,581,721,75
Zinc salt of glyphosate/TBS, 10:1
Total concentration, part./million82533008258251650825
Suppression, % 70407010080100
IP0,942,000,250,433,70to 1.86
Zinc salt of glyphosate/TBS, 1:10
Total concentration, part./million3300825330024753300825
Suppression, %60100901006080
IP1,580,50<1,006,201,940,64
Zinc salt of glyphosate/T Is C, 1:5
Total concentration, part./million330082533008258251650
Suppression, %601002010010080
IP1,780,50<1,001,920,611,50
Zinc salt of glyphosate/TBS, 1:3
Total concentration, part./million3300412247516504123300
701009010010060
IP2,000,250,753,500,373,50
Zinc salt of glyphosate
Total concentration, part./million82516503300412,5412,5412,5
Suppression, %701000100100100
TBS
is BSA concentration, part./million247516503300330024751650
Suppression, %701000808080

When the ratio TBS/zinc salt of glyphosate from 0.1:1 to 10:1 is observed effective synergies. Combinations in which the aforementioned ratio is from 0.1:1 to 1:1, are effective against Os-Gl. Combinations in which the aforementioned ratio is from 1:1 to 10:1, are effective against Ap-Ch.

1. A synergistic antimicrobial composition comprising a zinc salt of glyphosate and thiabendazol, where the mass ratio thiabendazol/ zinc salt of glyphosate is from 0.1:1 to 10:1.

2. A synergistic antimicrobial composition according to claim 1, where the mass ratio of the specified thiabendazol/specified zinc salt of glyphosate ranges from 1:1 to 10:1.

3. A synergistic antimicrobial composition according to claim 1, where the specified mass ratio specified thiabendazol/specified zinc salt of glyphosate is from 0.1:1 to 1:1.

4. The method of suppressing the growth of or controlling the growth of microor is Anisimov in building material, and this method includes a step of adding the specified construction material synergistic antimicrobial composition according to claim 1.

5. Composition for coating comprising a synergistic antimicrobial composition according to claim 1.

6. Dry film obtained by the method, which is that the layer of the composition for coating according to claim 5 is applied onto a substrate and dried specified composition for coating or withstand the specified composition for coating on the air for drying.



 

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FIELD: medicine.

SUBSTANCE: invention relates to disinfectants. An antiseptic disinfectant contains the film-forming preparation iodopyrone containing 6-8% of active iodine and water, contains ethanol in the following proportions, wt %: iodopyrone - 1.0-1.3 (per active iodine basis), ethanol - 20, water - the rest. The antiseptic disinfectant represents a ready-to-use preparation presented in the form of a solution or a spray.

EFFECT: invention provides the qualitative and quantitative stability of the active substance in the easily water-washable disinfectant which does not stain and has a non-irritant, prolonged effect If kept in an unopened container, it has a shelf-life of 2 years from the date of manufacture.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to bactericidal medication and can be applied for disinfection of livestock premises, placed in them technological equipment, implements for animal care, vehicles for transportation of animals, places where animals and other objects of veterinary supervision are concentrated. Medication includes alkyldimethylbenzylammonium chloride (ADMBAC), glutaric aldehyde, water and sodium hydroxide, taken in specified ratio. In case of specified ratio synergetic effect is observed and maximal bactericidal activity of medication, assessed by value of minimal bactericidal concentration (MBC), at which death of test-culture is observed, is reached.

EFFECT: invention ensures increase of bactericidal activity and reduction of medication toxicity with minimal content of active substances.

1 tbl, 15 ex

FIELD: medicine.

SUBSTANCE: invention refers to disinfection. The experimental method for the elimination of pathogenic and opportunistic microorganisms is characterized by the fact that a mixture containing the pathogenic and opportunistic microorganisms are processed with a disinfection composition which is metal oxyhydrate gel prepared by alkaline metal chloride deposition by 2% ammonia in a min. 5-litre reactor; fresh metal oxyhydrate 20-10-6 m3 is placed in an electrochemical cells with graphite electrodes of a charged cluster metal particle generator; what is added is a bacterial solution of the medium of 105 microbial cells in 1 ml dissolved in distilled water 10 ml; the medium is exposed to polarized currents of the cluster oxyhydrate particles of metal oxyhydrate gel for 2 to 6 hours; metal oxyhydrate gels are prepared by using metal chloride salts presented by zirconium or iron chloride salts with the electrode distance no more than 70 mm.

EFFECT: invention provides the more effective inactivation of pathogenic and opportunistic microorganisms that are infectious agents in human and animals.

7 tbl, 2 dwg, 6 ex

Antiviral agent // 2496522

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions discloses an antiviral agent (versions) able to inactive a virus. The antiviral agent characterised by containing the basic substance, cuprous microparticles, and inorganic microparticles to fix the cuprous microparticles on the basic substance. The inorganic microparticles are coupled together by chemical bonds formed between silane monomers found on the surface, and each of the inorganic microparticles is coupled with the basic substance by a chemical bond between silane monomer and the basic substance for the purpose of forming the areas wherein the above cuprous microparticles are expected to be accumulated.

EFFECT: group of inventions provides high antiviral activity.

16 cl, 3 tbl, 7 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfection. The composition contains hydrogen peroxide and an aqueous solution of copper or one of its derivatives, such as copper salts, as well as at least one salt of an anionic surfactant inhibiting decomposition of hydrogen peroxide in the presence of copper. The composition may be prepared immediately before use by mixing the aqueous solution of copper and the aqueous solution of hydrogen peroxide.

EFFECT: invention provides simultaneous disinfection and decontamination of the objects infected by special infectious agents (NCTA), such as prions, and common infectious agents (CTA), such as bacteria, yeast, viruses, mould spores, mycobacteria, bacterial spores.

23 cl, 5 tbl

FIELD: medicine.

SUBSTANCE: invention refers to public health, veterinary science, food processing, pharmaceutical and biotechnological productions. Disinfection objects are processed by the system of disinfectants consisting of at least two preparations, wherein at least one of the preparations is specified in a group of oxidants, namely oxygen-chlorine substances, and at least one of the preparations is specified in a group of non-oxidants, including, QACs - quaternary ammonium compounds, tertiary amines, aldehydes, guanidines. The system of disinfectants is packed within a package so that each preparation is placed separately, and each following preparation is used only after the previous preparation has been consumed completely.

EFFECT: invention provides the controlled rotation of disinfectants that prevents the developing acquired microorganism resistance.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly to stabilised aqueous antimicrobial compositions. The antimicrobial composition contains 2-25 wt % of 2,2-dibrom-3-nitrilopropionamide, 5-30 wt % of an aliphatic compound containing 2 to 6 hydroxyl groups, 20-70 wt % of ethylene glycol, 2-30 wt % of water.

EFFECT: invention provides stability and low viscosity of the composition.

10 cl, 5 ex

Disinfectant // 2481126

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

Disinfectant // 2481126

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

FIELD: chemistry.

SUBSTANCE: group of inventions relates to disinfection and sterilisation. The acidic liquid composition used is a liquid composition which contains (a) an acidic oxidant, (b) nitric acid or salt thereof and (c) at least one carboxylic acid selected from a group consisting of monocarboxylic acids, dicarboxylic acids and tricarboxylic acids, or salt thereof. In the disinfection and sterilisation method, the acidic liquid composition contains an acidic oxidant having an excellent corrosion inhibiting property (property of preventing rust, property of inhibiting formation of an oxide film) for aluminium-based metals even in acidic conditions, without affecting the appearance or function of such metals.

EFFECT: efficiently used to disinfect or sterilise an object having a part made from aluminium-based metals.

12 cl, 20 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to disinfectants. An antiseptic disinfectant contains the film-forming preparation iodopyrone containing 6-8% of active iodine and water, contains ethanol in the following proportions, wt %: iodopyrone - 1.0-1.3 (per active iodine basis), ethanol - 20, water - the rest. The antiseptic disinfectant represents a ready-to-use preparation presented in the form of a solution or a spray.

EFFECT: invention provides the qualitative and quantitative stability of the active substance in the easily water-washable disinfectant which does not stain and has a non-irritant, prolonged effect If kept in an unopened container, it has a shelf-life of 2 years from the date of manufacture.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to bactericidal medication and can be applied for disinfection of livestock premises, placed in them technological equipment, implements for animal care, vehicles for transportation of animals, places where animals and other objects of veterinary supervision are concentrated. Medication includes alkyldimethylbenzylammonium chloride (ADMBAC), glutaric aldehyde, water and sodium hydroxide, taken in specified ratio. In case of specified ratio synergetic effect is observed and maximal bactericidal activity of medication, assessed by value of minimal bactericidal concentration (MBC), at which death of test-culture is observed, is reached.

EFFECT: invention ensures increase of bactericidal activity and reduction of medication toxicity with minimal content of active substances.

1 tbl, 15 ex

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to using derivatives of dithiocarbamate of the formula: R1R2NCS2H and oxidized forms of these compounds, in particular, their dimmers and their pharmaceutically compatible salts for preparing an agent used in treatment or prophylaxis of infection caused by RNA-containing viruses that damage respiratory tract and inducing disease. Also, invention relates to a disinfecting agent containing dithiocarbamate compound and a method for disinfection of surfaces, media and cell cultures.

EFFECT: valuable medicinal properties of compounds.

19 cl, 14 dwg, 14 ex

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