Antiviral agent

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions discloses an antiviral agent (versions) able to inactive a virus. The antiviral agent characterised by containing the basic substance, cuprous microparticles, and inorganic microparticles to fix the cuprous microparticles on the basic substance. The inorganic microparticles are coupled together by chemical bonds formed between silane monomers found on the surface, and each of the inorganic microparticles is coupled with the basic substance by a chemical bond between silane monomer and the basic substance for the purpose of forming the areas wherein the above cuprous microparticles are expected to be accumulated.

EFFECT: group of inventions provides high antiviral activity.

16 cl, 3 tbl, 7 ex

 

The area of technical applications

The present invention relates to an antiviral agent that has a high inactivating effect against various viruses, regardless of whether the shell.

Background of the present invention

In recent years, there have been reports of increasing cases of death resulting from viral infections such as severe acute respiratory syndrome (SARS), norovirus and bird flu. In addition to this. Currently, due to more developed transportation networks, and also because of the constant migration of viruses global risk is the risk of a pandemic, in which the viral infection is spreading all over the world; therefore, it is necessary to adopt urgent countermeasures.

Despite the fact that in order to solve this problem, the development of antiviral agents based vaccines accelerated, however, due to the specificity of vaccines they are able only to prevent those infections that are caused by specific viruses. In addition, a serious problem is also a nosocomial infection in hospitals and medical clinics, caused by a contagious infection methicillin resistant Staphylococcus aureus, which is listed in the hospital a carrier or infected subject, or a mutant form of Staphylococcus aureus, due to the introduction of antibioti is and mutating in methicillin-resistant Staphylococcus aureus, directly by the patient or staff, or by the environment (which includes used items, the type of medical service, pajamas, sheets), and transmission to other patients and the nurses, which speed up the walls and air conditioning systems. Therefore, there is an extraordinary need for antiviral tool that can demonstrate effective antibacterial and antiviral activity against various viruses and bacteria.

Viruses can be divided into those that are surrounded by a lipid-containing membrane, called the "shell", and viruses do not have a shell. Because the shell consists mainly of lipids, it can easily be dissolved by treatment with ethanol, an organic solvent, soap or similar tool. Therefore, despite the fact that the viruses in the shell are usually easy to kill, it is believed that the virus without membranes are highly resistant to such treatment.

In order to solve these problems as antiviral agents have been proposed inorganic antiviral agents that have a broader effect than organic methods. For example, as a product that inactivates (reduces the infectivity of the virus or deactivates) the influenza virus, we offer a fabric containing anti-Christ. arterialnoe coloring agent and divalent ions of copper (patent document 1). In addition, there are also antiviral fiber, contain copper compounds with a carboxyl group (patent document 2). As a product, inactivating the virus avian influenza, are also obtained by cold working the ultra-thin copper fiber (patent document 3).

Patent document 1 to patent application laid Japan No. 2006-188499

Patent document 2 international patent application No. 2005/083171, brochure

Patent document 3 - laid patent application of Japan No. 2008-138323

The disclosure of the present invention

Tasks that should be solved by the present invention

However, when using the method, which uses ions of bivalent copper, these copper ions need to be stabilized by mixing them with other substances so that in the resulting composition, the amount of copper ion was limited. In other words, for ions of bivalent copper significantly the presence of the stabilizing means. Therefore, the degree of freedom in designing antiviral composition is small. Further, because if the carboxyl-containing fiber includes a compound of copper, in addition to the carboxyl group requires the presence of salt and provide a number of copper compounds is limited, thus inhibiting the expression of sufficient promuovere the Noah efficiency. In addition, when using metallic copper on its surface stick of contamination, type oxide film, therefore, the effect of antiviral activity drastically decreases. Therefore, in order to maintain a certain antiviral activity occurs, the task, the need for constant special treatment, and this means that the maintenance activity is required.

Thus, to solve the above problems the present invention provides an antiviral agent, which is able to inactivate viruses, as well as a product that uses this antiviral agent.

Ways to solve these problems,

In particular, a first aspect of the present invention is an antiviral agent, comprising the substrate, the particles of the compounds of monovalent copper, the group of inorganic particles, which is used for attaching the particles of the compounds of monovalent copper on the substrate, and which contain a silane monomer, chemically associated with this surface. These inorganic particles, including on the surface of the silane monomer are linked together by chemical bonds formed between wilanowie monomers on the surface of these inorganic particles, and the group of inorganic particles is connected with the substrate through the om chemical bonds between wilanowie monomers on the surface of the inorganic particles and the substrate, moreover, the group of inorganic particles forms a zone for fixing particles of compounds of monovalent copper.

The second aspect of the present invention is an antiviral agent, comprising coating the substrate with a slurry in which inorganic particles containing silane monomer with unsaturated position binding or reactive functional group chemically bound to the surface, and the particles monovalent copper compounds are dispersed, making inorganic particles with celanova monomer chemically bonded to its surface, bound to each other by chemical bonds formed between these wilanowie monomers on the surface of the inorganic particles, and making the group of inorganic particles chemically bound to the substrate by chemical bonds formed between unsaturated position binding or reactive functional group Milanovich monomers and the surface of the substrate, thus forming zone to consolidate the particles of compounds of monovalent copper, and consolidation of these particles in the zone.

The third aspect of the present invention is an antiviral agent according to the first or second aspects, characterized in that the said chemical bond between wilanowie monomers and not the content of inorganic fillers particles represent a covalent bond, formed by dehydrogenation condensation, and chemical bonds between wilanowie monomers are covalent bonds formed by radical polymerization, and chemical bonds between wilanowie monomers and the substrate are covalent bonds formed by graft polymerization.

Further, the fourth aspect of the present invention is an antiviral agent according to the third aspect of the present invention, characterized in that the radical polymerization is a radical polymerization induced by irradiation (radiation radical polymerization), and the graft polymerization is a graft polymerization induced by irradiation (radiation graft polymerization).

The fifth aspect of the present invention is an antiviral agent according to any one of 1-4 aspects of the present invention, characterized in that the particles of the compounds of monovalent copper are associated with the specified inorganic particles by a binder, which is a monomer, oligomer, or a mixture.

Further, the sixth aspect of the present invention is an antiviral agent according to any one of 1-5 aspects of this is about invention, characterized in that the particles of the compounds of monovalent copper formed by the chloride, acetate, sulfide, iodide, bromide, peroxide, oxide, hydroxide, cyanide, thiocyanate, or mixtures thereof.

The seventh aspect of the present invention is an antiviral agent according to any of 1-6 aspects of the present invention, characterized in that the particles of the compounds of monovalent copper is formed at the lower of one kind of compounds selected from the group consisting of CuCl, CuOOCCH3, CuI, CuBr, Cu2O, CuOH, Cu2S, CuCN and CuSCN.

Further, the eighth aspect of the present invention is an antiviral agent according to any of 1-7 aspects of the present invention, characterized in that the particle content of the compounds of monovalent copper is from 0.1 wt.% up to 60 wt.% the total content of solids on the substrate

The ninth aspect of the present invention is an antiviral agent according to any of 1-8 aspects of the present invention, characterized in that the substrate is a fibrous structure. As such fibrous structures may use known structures. Their examples include filter air conditioner, net, net to protect from insects, mosquito net, bedding, clothing and protective wt is I. In addition, the substrate used in the present invention may be, for example, the film or sheet material. The substrate used in the present invention, for example, may be shaped material body panels, structural material, and material for the interior.

The advantages of the present invention

According to the present invention can provide an antiviral agent, which, even when the adhesion of various viruses (like viruses, which are surrounded by a membrane, called the "shell" and containing lipids; or viruses, does not have shell), is able to inactivate subjected to the adhesion of the virus more easily than usual, and the product produced when using the specified antiviral agents.

The best way to implement the present invention

Further antiviral agent according to the present invention will be described in detail with reference to the figures.

Figure 1 is an enlarged diagram schematically illustrating part of a cross-sectional antivirals 100 according to the present invention. In the specified antiviral tool 100 according to a variant of particle 2 connections monovalent copper, possessing antiviral activity, are fixed on the substrate 1 with the help of a group of 10 reorgan the ical particles 3, with which the silane monomers 4 are connected by a chemical bond 8 (covalent bond)formed by the reaction of dehydrogenation condensation.

Despite the fact that at the present time inactivation mechanism of viruses is not fully clear, it is assumed that if the connection monovalent copper comes in contact with atmospheric moisture, the part of the said compounds of copper tends to form a more stable ions of bivalent copper, for this is the release of an electron. I believe that according to the presented variant of the released electrons affects the electrical charge on the surface of viruses, adhesive associated with antiviral 100, DICK virus, or the like, while the virus is inactivated.

Antiviral agent 100 under this option demonstrates antiviral activity, even if the particles 2 connections monovalent copper, which represents the active component, are mixed with a stabilizing agent or similar substances. In particular, the antiviral agent 100 according to the present variant can be designed with a greater degree of freedom than standard antiviral compositions that use ions of bivalent copper and the like.

Further, in antiviral tool 100 according to the present variant, the particles 2 connections on novecentos copper, which represents the active component, held in zone 9, formed by the group 10 of inorganic particles 3 mounted on the substrate 1, so they are not covered with the binder or the like. Therefore, the density of particles 2 connections monovalent copper on the substrate 1 can be increased, and the probability of contact of the virus, the adhesive associated with the surface of antivirals 100, and particles 2 connections monovalent copper may increase. In addition, the effectiveness of antiviral activity is much higher than the standard antiviral drug, which is disguised as a binder antiviral agent is not able to demonstrate their activity sufficiently. In addition, in contrast to metallic copper, antiviral activity which, if not to carry out special treatment, is reduced due to formed on the surface of the oxide film, even without the implementation of special treatment or similar inactivating activity of the virus can be maintained over a longer period of time.

Despite the fact that particle type 2 connections monovalent copper, which is the active component, unlimited, however, preferred are chloride, acetate, sulfide, iodide, bromide, peroxide, oxide, hydroxide, cyanide or thiocyanate, or mixtures thereof. Of them significantly bol is e preferred than particle 2 connections monovalent copper is at least one compound selected from the group consisting of CuCl,Cu CH3COO, CuI, CuBr, Cu2O, CuOH, Cu2S, CuCN and CuSCN.

Further, although the size of the included particles 2 connections monovalent copper is not significantly limited, it is preferable that the average size of these particles was 500 μm or less. If the average particle size greater than 500 μm, the surface area of particles per unit mass decreases, and this means that the antiviral effect is smaller than an average particle size of 500 μm or below. In addition, its own texture the surface of the substrate 1 is broken compared to a case when the average particle size was 500 μm or less, and attaching to the substrate 1 is weakened, so the particles 2 connections monovalent copper tend to otshelushivatsya and, due to friction forces, leaving the substrate 1. In particular, for such fibrous structures, as the filter mesh and clothing, or for sheet material or film is bonded with the surface of the substrate 1 (the type of fiber or sheet material) particles 2 monovalent copper compounds can otshelushivatsya due to certain environmental conditions or over time. Therefore, considering the adhesive strength of the film, it is preferable that the average particle size of 2 odnov entogo copper compounds was 10 nm or more, up to 1 μm or less.

In order to harden the particles 2 monovalent copper compounds can be (optional) are connected by a chemical bond with the inorganic particles 3 through the connecting component 6 formed from a monomer, oligomer or mixture thereof and acting as a hardening additive.

In other words, according to this variant of the antiviral agent 100 may contain a binder component 6 formed from a monomer, oligomer or mixture thereof and connecting particles 2 connections monovalent copper and inorganic particles 3 in a state that supports the antiviral activity of the particles 2 connections monovalent copper (in this state at least part of the particles 2 connections monovalent copper is on the outside).

Further, in addition to particle 2 connections monovalent copper fixed in zone 9, formed by the group 10 of inorganic particles 3 mounted on the substrate 1, an antiviral agent 100 may also contain particles 2 connections monovalent copper, attached to the surface of the specified antivirals 100 via a chemical bond with inorganic particles 3 with a binder, as shown in figure 1.

In addition, as shown in figure 1, in addition to the binding particles 2 connections monovalent copper and not the content of inorganic fillers particles 3 specified binder component 6 can also bind particles 2 connections monovalent copper and the substrate 1, particles 2 connections monovalent copper to each other, as well as inorganic particles 3 with each other.

The amount of binder component 6 can be appropriately set in such a range, which is the effect of this component as a binder, and is also supported antiviral activity of particles 2 connections monovalent copper.

Further, as mentioned above in the examples of the binder component 6, although in the present embodiment, the specified binding component 6 forms a covalent bond 8 formed by dehydrogenation condensation for a chemical bond with the particles 2 connections monovalent copper, inorganic particles 3 and the substrate 1, however, the binder component 6 is not limited, and it may be linked to chemical bond or absorbed in some other way.

If the specified binding component 6 is a monomer, the examples may include a monomer with a reactive functional group, type vinyl groups, acryloyloxy groups, amino groups, amide groups, isocyanate groups, epoxy groups, carboxyl groups, hydroxyl groups and silanol groups. Other examples include monofunctional, bifunctional and polyfunctional vinyl monomers, such acrylate, methyl acrylate, the acrylate is, n-butyl acrylate, 2-hydroxyethylacrylate, methyl methacrylate, 2-hydroxyethylacrylate, acrylamide, methacrylamide, Acrylonitrile, vinyl acetate, ethylene, styrene, propylene, butadiene, vinyl chloride, formaldehyde, basis of itaconic acid, methyl acrylate, triacrylate of trimethylolpropane and triacrylate pentaerythritol. You can use one type or a mixture of two or more kinds of these monomers.

If the specified binding component 6 represents the oligomer, the examples may include unsaturated polyester, unsaturated acrylic resin, epoxyacrylate, acrylate complex polyester, polyether acrylate, acrylate polybutadiene, silicone acrylate, maleimide, Polian/politial and oligomer alkoxides. In the case of oligomers is also possible to use one kind or a mixture of two or more kinds of these oligomers.

Further, in the present embodiment, in order antiviral agent 100 has been vested with the necessary functions on the surface of the substrate 1, in addition to particle 2 monovalent copper compounds, can also be secured or supported arbitrarily used performance materials. Examples of such operating materials include other antiviral compound, an antibacterial compound, an antifungal composition, antiallergic composition, catalyst, proceviat arately material, as well as the material having heat-insulating properties.

Although under this option, the number of particles 2 monovalent copper compounds antiviral agent can be set arbitrarily, given the purpose and application for which the tool will be used, and the size of the particles 2 monovalent copper compounds, however, it is preferable to use an amount of 0.1 wt.% up to 60 wt.% based on the total solids content in the substrate 1. If the content of particles 2 monovalent copper compounds is less than 0.1 wt.%, the antiviral effect is lower than if the content is in the above range. On the other hand, if the content of particles 2 monovalent copper compounds is more than 60 wt.%, despite the difference in antiviral activity compared to the activity content of 60 wt.%, the adhesion strength of the group 10 of inorganic particles 3 to the substrate 1 may be lower than if the content is in the above range.

In the present embodiment, the group 10 of inorganic particles fixed on the substrate 1 in order to retain particles 2 monovalent copper compounds on the surface of the specified substrate 1. Silane monomers 4 are associated with the surfaces of inorganic particles 3, forming a group of 10 reorganize is such particles through the formation of chemical bonds 8 (covalent bond), occurs when the reaction dehydrogenation condensation. Inorganic particles 3 are connected to each other by chemical bonds 7 (covalent bond)is formed between the positions of binding or reactive functional groups Milanovich monomers 4, which are connected with the surfaces of inorganic particles 3.

Next, the group 10 of inorganic particles 3 is fixed to the surface of the substrate 1 by chemical bonds (covalent bond) 5 formed between wilanowie monomers 4 and the substrate 1. On the specified substrate 1 are formed in zone 9 for fixing particles 2 monovalent copper compounds, it is due to the chemical bonds between the inorganic particles 3 and the ties between the group 10 of inorganic particles 3 and the substrate 1. Particles 2 monovalent copper compounds are fixed in zones 9 in the blocking state. These zones 9 from the outside is connected to the group 10 of inorganic particles 3, so that the particles 2 monovalent copper compounds are fixed on the substrate 1 in this state, when their antiviral activity is preserved.

In other words, under this option on the specified substrate 1 particles 2 monovalent copper compounds surrounded by at least inorganic particles 3 and wilanowie monomers 4 that chem is logically associated with these inorganic particles 3 in this state, when their antiviral activity is preserved.

In particular, under this option antiviral tool 100 is used silane monomers 4, with significant reactivity because they are unsaturated positions of binding or reactive functional group to bind silanolate group these Milanovich monomer 4 with the surfaces of inorganic particles 3 through chemical bonds (covalent bond)formed in the reaction dehydrogenization condensation.

Further, inorganic particles 3 are connected to each other by chemical bonds (covalent bond)formed by radical polymerization between wilanowie monomers 4, associated with the surfaces of inorganic particles 3.

In addition, for example, the group 10 of inorganic particles 3 are attached to the substrate 1 by chemical bonds 5 (covalent bond)produced by graft polymerization between the surfaces of the substrate 1 (the type of fiber, film, or sheet material) and unsaturated positions of binding and reactive functional group Milanovich monomers 4.

Thus, the group 10 of inorganic particles 3 are firmly fixed to the substrate by chemical bonds. Therefore, to a much greater extent than the standard versions (in which the fixing of the particles is achieved by coating them with a special component, the type of binder) is suppressed by the subsidence of the specified substrate 1 particles 2 connections monovalent copper fixed in zones 9 formed on the substrate 1 by chemical bonds between the inorganic particles 3 and the chemical bonds between the group 10 of inorganic particles 3 and the substrate 1. Therefore, under this option antiviral agent 100 is able to maintain antiviral activity longer than standard versions.

Next, the particles 2 connections monovalent copper can be mounted on the substrate 1 in this state, in which the binder component (or similar) not related chemical bond, or in the condition in which at least part of the surface of the particles 2 connections monovalent copper is outside. Therefore, under this option antiviral agent 100 is able to demonstrate a higher antiviral activity than with the method of attachment of a standard binder, in which the surface antiviral component is completely covered with the binder component.

In addition, on the surface of antivirals 100 group 10 of inorganic particles 3 mounted on the substrate 1, is formed protrusions crystals (smaller than dust), which inhibit the adhesion of dust or the like. Sledovat is Ino, since it is possible to block floor dust the surface of antivirals 100, the antiviral activity can be maintained much longer than the standard versions.

These inorganic particles 3 can represent particles of compounds of monovalent copper, or they may be inorganic particles other than the particle compounds of monovalent copper. In particular, the inorganic particles 3 can be formed from an oxide of a nonmetal, metal oxide, complex oxide, or mixtures thereof.

Further, inorganic particles 3 can be amorphous or crystalline. Examples of nonmetal oxides include silicon oxide. Examples of metal oxides include magnesium oxide, barium oxide, barium peroxide, aluminum oxide, tin oxide, titanium oxide, zinc oxide, titanium peroxide, zirconium oxide, iron oxide, iron hydroxide, oxide of tungsten, an oxide of bismuth and indium oxide. Examples of complex metal oxides include barium-titanium oxide, cobalt-aluminum oxide, lead-zirconium oxide, niobium-lead oxide, TiO2-WO3, AlO3-SiO2WO3-ZrO2and WO3-SnO2.

Despite the fact that the size of the inorganic particles 3 (average volumetric particle size) may be arbitrarily set depending on the use of protover what red means, and the size of the particles of the compounds of monovalent copper, depending on the strength of binding with the substrate 1, it is preferable to set the particle size up to 300 nm or less, and still more preferably up to 100 nm or less.

Examples Milanovich monomers 4, chemically associated with the surface of the inorganic particles include silane monomers having unsaturated positions of binding or reactive functional group, type vinyl groups, epoxy groups, styrene groups, methacryloyloxy group, aryloxy group, isocyanate group and Tilney group.

Specific examples include VINYLTRIMETHOXYSILANE, vinyltriethoxysilane, VINYLTRIMETHOXYSILANE, N-β-(N-vinylbenzyl-amino-ethyl)-γ-aminopropyltrimethoxysilane, hydrochloride N-(vinylbenzyl)-2-amino-ethyl-3-aminopropyltrimethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, 3-glycidoxypropyl-ethoxysilane, 3-glycidoxypropyltrimethoxysilane, 3 glycidate-propyltriethoxysilane, p-sterlitamatskaya, 3 metacrilate-propylmethyldimethoxysilane, 3 methacryloxypropyltrimethoxy-silane, 3-methacryloxypropyltrimethoxysilane, 3 metacrilate-propylmethyldimethoxysilane, 3-acrylonitrilebutadiene, 3-isocyanatopropyltrimethoxysilane and connection alkoxysilane represented by the formula Si (OR1)4(in which R1 before the hat is alkyl group, containing from 1 to 4 carbon atoms), for example, tetramethoxysilane and tetraethoxysilane, and the connection alkoxysilane represented by the formula R2xSi (OR3)n(in which R2 represents a hydrocarbon group containing from 1 to 6 carbon atoms, R3 represents an alkyl group containing from 1 to 4 carbon atoms, x=(4-n), a n denotes an integer from 1 to 3), for example, methyltrimethoxysilane, methyltriethoxysilane, dimethyldiethoxysilane, phenyltriethoxysilane, hexyltrimethoxysilane, hexamethyldisilazane.

Viruses that can be inactivated under this option using antivirals 100 is not specifically limited. Possible inactivation of different viruses, regardless of the type genome or shell.

Examples of such viruses include rhinovirus, poliovirus, rotavirus, norovirus, enterovirus, hepatovirus, Astrovirus, sapovirus, hepatitis E virus, influenza virus A, B and C, parainfluenza virus, mumps virus, measles virus, human metapneumovirus, virus, yellow fever virus, dengue fever, Japanese encephalitis virus, West Nile virus, hepatitis B and C, Western and Eastern equine encephalitis viruses, the virus' nuong-nuong, rubella virus, the virus Lhasa, the virus Machupo, virus Guanarito, virus Sabia, virus gemorrargicheskoj fever Congo, VI is the us phlebotomus fever, virus Hante, rabies virus, the causative agent of hemorrhagic fever Ebola virus Marburg virus Las bat virus leukemia T-cells, human immunodeficiency virus, human coronavirus, SARS coronavirus, parvovirus, human, polyomavirus human, human papilloma virus, adenovirus, herpes virus, varicella zoster virus, zoster virus, cytomegalovirus, smallpox virus, Monkeypox virus, the smallpox of the cow, the smallpox virus shellfish and parapoxvirus.

Under this option the substrate 1 in the antiviral tool 100 may be a fibrous structure, film, sheet material or the molded product (panel type) so that the particles 2 connections monovalent copper could be held on a variety of surfaces.

Under this option the substrate 1 antivirals 100 may be an arbitrary substance as a chemical bond with 5 wilanowie monomers 4 on inorganic particles 3 can be formed with a specified surface of the substrate 1. Examples of the substrate 1 include this substrate, the surface of which is formed at least from different types of resins, synthetic fibers, natural fibers (like cotton, hemp, silk) and Japanese paper, obtained from natural fibers.

E. what does the surface of the substrate 1, or if specified, the entire substrate is formed of resin, it is possible to use synthetic or natural resins.

Their examples include thermoplastic resins such as polyethylene resin, polypropylene resin, polystyrene resin, resin plant resin, Acrylonitrile resin, ethylvinylacetate resin, polymethylpentene resin, polyvinyl chloride resin, polyvinylidenechloride resin, polymethyl-methacrylate resin, polyvinyl acetate resin, polyamide resin, polyimide resin, polycarbonate resin, polyethylene terephthalate resin, polybutyleneterephthalate resin, polyacetylene resin, polyacrylate resin, polysulfone resin, PVDF resin, Vectran and polytetrafluoroethylene; biodegradable resins such as polylactic acid resin, polyhydroxyalkane resin, resin modified starch, polycaprolactone resin, polybutylmethacrylate resin, polybutyleneterephthalate resin, poliatilenaksida terephthalate resin and polyethyleneterephtalate resin; thermosetting resins such as phenolic resin, urea resin, melamine resin, unsaturated polyester resin, diallylphthalate resin, epoxy resin, epoxyacrylate resin, silicone resin, acrylourethane resin and urethane resin; elastomers such as silicone smo is a, polystyrene elastomer, polyethylene elastomer, polypropylene elastomer and polyurethane elastomer; and natural resins, types of Japanese lacquer.

Further, even if the substrate 1 is formed of metal material (such as aluminum, stainless steel or iron), or inorganic material (glass or ceramic), then, as in the case of a substrate made of resin, the group 10 of inorganic particles 3 can be fixed on the metal substrate 1, for example, in the formation of chemical bonds 5 by reacting unsaturated positions of binding or reactive functional group of the silane monomer 4 with a hydroxyl group (or similar) on the metal surface under the above graft polymerization.

On the other hand, the group 10 of inorganic particles 3 can be firmly fixed by introducing a functional group that can bond chemically with the surface of the substrate 1 by, for example silane monomer or titanium monomer.

Examples of the functional group, which is derived from a silane monomer, introduced on the surface of the substrate 1 include vinyl group, epoxy group, stielow group, methacryloyloxy group, aryloxy group, isocyanate group and Tilney group.

Under this option the substrate 1 antivirals 100 will be described hereinafter in more detail.

Examples of the fibrous structure, which is in accordance with the present variant example of the substrate 1 include woven and non-woven materials. Specifically applicable examples include protective masks, filters, air, filters, air cleaner filters, vacuum cleaner, filters, fans, automotive filters, clothing, bedding, protective door mesh network for poultry and mosquito net.

Fibrous structure in these examples formed from fibers of polymeric materials such as polyester, polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate, polybutylene terephthalate, poly-tetramethyleneglutaric, nylon, acrylic, polytetrafluoroethylene, polyvinyl alcohol, Kevlar (extra strong synthetic fiber), polyacrylic acid, polymethyl methacrylate, viscose, Tencel, long fiber blend of viscose with polyester, acetate, triacetate, cotton, hemp, wool, silk and bamboo; or of such metal materials such as aluminum, iron, stainless steel, brass, copper, tungsten and lead.

Further, according to this variant, the substrate antivirals 100 may also be a film or sheet material. If the specified substrate 1 represents a film, it can be shaped, for example, from a resin, polyester resin, polyethylene is the first resin, polyamide resin, polyvinyl chloride resin, polyvinyl alcohol, polyvinylacetate, polyamide, polyamidimide, polyamidimide, polytetrafluoroethylene, and tetrafluoroethylene copolymer. If the specified substrate 1 is a sheet material, the examples will include a sheet material formed from such a polymer like polycarbonate sheeting/film, vinyl chloride sheet material, PTFE sheet material, plastic sheet material, silicone sheet material, nylon sheet material, resin plant leaf material, as well as urethane sheet material; and a sheet material made of such metals as titanium, aluminum, stainless steel, magnesium and brass.

If the substrate 1 is a film or sheet material, in order to improve the adhesion of the group 10 of inorganic particles 3 to the substrate 1 for fixing particles 2 connections monovalent copper is preferred in advance hydrophilicity specified substrate, which is carried out by surface treatment by corona discharge, atmospheric plasma, flame or the like. Further, if the sheet material is made of metal, it is preferable to remove the emulsion for lubrication, corrosion products and the like, the adhesive associated with what Ernesto, this is carried out, for example with a solvent, acid or alkali. In addition, the surface of the sheet material can also be painted, it can be transferred pattern and the like.

Sheet material or film, on which the fixed particles 2 connections monovalent copper, can be used in various fields, for their example are: Wallpapers, Windows, blinds, materials for interior finishing of buildings (like hospitals), materials for interior finishing trains, automobiles and the like, the sheet material for automobiles, blinds, seats, sofas, equipment used when working with viruses, as well as construction materials such as doors, ceiling panels, boards for flooring, and Windows.

In addition, under this option antiviral agent 100 can also be used in the form of a cast product, the type of panel material for interior decoration and construction materials. Their examples may include the molded product of the polymer, such as acrylonitrilebutadienestyrene, nylon, polypropylene, polystyrene, Polyacetal and polyester; or from the product metal, such as aluminum, zinc, magnesium, brass, stainless steel and titanium.

The metal surface may be pre-coated with a thin metal film using the electro-deposition or electro-deposition at electroly is e; or given surface can be subjected to painting or drawing. If the particles 2 connections monovalent copper is fixed on the surface of the writing instrument, handrails, lanyard, phone, toys, door handles and the like, it is possible to prevent a situation in which a healthy subject's becoming infected with the virus after contact with the object or the part of it that was used by an infected subject.

Further, the receiving antivirals 100 according to the present variant, containing copper chloride (I) as an example of particle 2 compounds of monovalent copper, will be described in more detail. If this way of getting on the substrate 1 as the coating suspension is applied, in which the inorganic particles 3 with wilanowie monomers 4 containing unsaturated positions of binding or reactive functional groups chemically bound to their surface, and dispersed chloride copper (I). Then make the silane monomers 4, chemically bonded with the surface of inorganic particles 3, associated with each other by chemical bonding to the group 10 of inorganic particles 3, connected by means of specified Milanovich monomers 4.

In accordance with this, the group 10 of inorganic particles 3 containing silane mon which measures 4, associated chemical bond with the surface of these particles is connected with the substrate 1. This relationship between the group 10 of inorganic particles 3 and the substrate 1 is formed by chemical binding between unsaturated or reactive groups Milanovich monomers 4 and the surface of the substrate 1. As a result of this form of zone 9 for fixing chloride copper (I)chloride copper (I) is fixed in zones 9.

Chloride copper (I) is crushed to particles of micron size, it uses a jet crusher, hammer crusher, ball mill, vibration mill and the like.

After that, the crushed copper chloride (I) is mixed with a binder component bis inorganic particles 3, which due to the dehydrogenation condensation chemically bonded silane monomers having unsaturated positions of binding or reactive functional groups. The resulting mixture is dispersed in a solvent of water, methanol, ethanol, acetone, xylene and toluene. During this process, in addition to the inorganic particles 3 and chloride copper (I) may also be mixed with other substances, for example, the connecting component 6 and the functional substances. After that, in order to obtain a suspension in which the dispersed particles of copper chloride (I), add (optional) disperser the substance abuser, type surfactants. The resulting mixture was dispersed and crushed for use with devices such as ball mill, sand mill, a roller mill, a vibration mill or a homogenizer.

Thus, the particle size of the compounds of monovalent copper 2 and inorganic particles 3 is reduced so that the particles of the compounds of monovalent copper 2 and the inorganic particles 3 are arranged on the surface of the substrate 1 without excessive gaps between the particles. Therefore, the density of particles of compounds of monovalent copper 2 cannot be increased, and the group 10 of inorganic particles 3 may be firmly fixed on the substrate 1.

Therefore, a high antiviral activity can be demonstrated over a longer time than usual. Chemical bond (covalent bond) between 8 inorganic particles 3 and wilanowie monomers 4 having unsaturated positions of binding or reactive functional group can be formed based on a simple method for the dehydrogenation reaction of condensation.

Chemical bond (covalent bond) between 8 inorganic particles 3 and wilanowie monomers 4 having unsaturated positions of binding or reactive functional group, can b is to be formed using a simple method.

For example, silane monomers 4 can be introduced into the dispersion of inorganic particles 3, and then to make it so that when heated with return phlegmy by the reaction of dehydrogenation condensation has formed a covalent bond 8 with the surfaces of inorganic particles 3, thus forming a thin film consisting of Milanovich monomers 3.

Further, as another method, first silane monomers 4 can be introduced into the dispersion of inorganic particles 3, which were crushed to particles. Alternatively, the inorganic particles 3 can be obtained by adding particles of inorganic compounds 3 and silane monomers 4 in the dispersion medium, and then grinding these particles of inorganic compounds in the inorganic particles 3. Then carry out the separation solid-liquid, the resulting product is heated to a temperature from 100°C to 180°C, so that the silane monomers by reaction of dehydration condensation has formed a covalent bond 8 with the surfaces of inorganic particles 3. In conclusion, the inorganic particles 3, with which the silane monomers 4 are connected by a chemical bond, again crushed and shredded, and then dispersed.

If inorganic particles 3 and silane monomers 4 involve the covalent bond method described above as an example, the STA is in Milanovich monomers 4 (although it also depends on the average size of the inorganic particles 3) is from 0.01 wt.% to 40.0 wt.% by weight of inorganic particles 3. In this case, difficulties in the strength of bonding between the inorganic particles 3 or between the group 10 of inorganic particles 3 and the substrate 1 is almost nonexistent. In addition, it is possible that the silane monomers 4, not involved in this binding, was in excess.

The resulting suspension is applied as a layer on the surface of the fiber, film or sheet material, for this purpose use this method, as immersion, spraying, coating, roller coating when removing the excess strap, coating by centrifugation, coating gravure printing, coating, offset printing, coating, screen printing and coating ink printing. Then (optional) the solvent is removed, for example, by heating and drying.

Then unsaturated positions of binding or reactive group Milanovich monomers 4 related chemical bond with the surface of inorganic particles 3, which faces the surface of the substrate 1, lead to the formation of covalent bonds 5 with a functional group on the surface of the substrate 1. These bonds are formed by Pref is the polymerization, which is induced by reheating or by graft polymerization, radiation-induced (type IR-irradiation, UV-irradiation, irradiation of electron beams or γ-rays), the so-called radiation graft polymerization. In the present embodiment, from the above, it is preferable to choose radiation graft polymerization.

Further, in the process of such graft polymerization by re-heating or IR-irradiation, UV-irradiation, irradiation of electron beams or γ-rays inorganic particles 3 are also linked to each other due to the formation of chemical bonds (covalent bond) 7 by means of radical polymerization of unsaturated positions of binding or reactive functional groups Milanovich monomer 4 with the surfaces of the particles.

In particular, between wilanowie monomers through radical polymerization induced by reheating or radical polymerization, which is caused by irradiation (IR-irradiation, UV-irradiation, irradiation of electron beams or γ-rays), the so-called radical radiation polymerization, the formation of a chemical bond (covalent bond) 7. In the present embodiment, from the above, it is preferable to choose radical radiation polymerization.

Thus forming zone 9 for fixing chloride copper (I) on the substrate 1, and chloride copper (I) is fixed in the specified zones 9. Further, if the added binder component 6, it can cause the formation of chemical bonds with the particles of the compounds of monovalent copper 2 and the inorganic particles 3 through a dehydration condensation due to, for example, re-heat or infrared irradiation, UV-irradiation, irradiation of electron beams or γ-rays in the process of graft polymerization.

Based on the above stages under this option, you may receive antivirals 100, in which particles of monovalent copper compounds 2, possessing antiviral activity, are fixed on the surface of various substrates 1.

Although the above has been specified a particular variant of the present invention, in him, in accordance with the displacement of the previously described technical material, it is possible to make various changes.

For example, the thickness of the group 10 of inorganic particles 3 (in other words, the number of particles 2 connections monovalent copper and inorganic particles 3, fixed to the substrate 1) can be set arbitrarily in accordance with the application specified antivirals 100.

Further, although the group 10 of inorganic particles 3 can be fixed on the entire substrate 1 in the form of layers, the present invention is not limited aceveda.

For example, the group 10 of inorganic particles 3 can be fixed on one or more portions of a surface of the substrate 1 as non-group, in the form of lines or Islands.

Examples

Next, using the proposed examples of the present invention will be described in more detail. However, only these examples of the present invention is not limited.

Receiving antivirals

Examples 1-1-1-9.

As commercially available compounds of monovalent copper powders of copper chloride, copper iodide, thiocyanate copper and copper oxide (manufactured by Wako Pure Chemical Industries, Ltd., Wako Analytical Grade) were solchany on the jet mill to an average particle size of approximately 5 microns. Grains of zirconium oxide (manufactured by Nippon Denko Co., Ltd., PCS), which contain methacryloxypropyltrimethoxysilane (obtained from Shin-Etsu Chemical Co., Ltd., KBM-503), which is a silane monomer with unsaturated position of binding covalently bound to their surface via a standard way of dehydration condensation, as well as the above-described compounds of monovalent copper was dispersible in methanol. After that, to obtain a suspension containing the compound of monovalent copper, spent grinding and dispersing in a ball mill.

Thereafter, the resulting suspension containing the compound of odnevall nteu copper, sprayed at 40 g/m2non-woven viscose material (produced by Shinwa Corp.) and spent drying at 100°C. and Then for making antivirals with this coating material was irradiated with 5 Mrad of electron beams at an accelerated voltage of 200 Volts. Table 1 shows the ratio (wt.%) content connections monovalent copper from the total content of the compounds of monovalent copper and Zirconia particles which are chemically bonded silane monomers having unsaturated position binding; both are fixed on the surface of non-woven viscose material. In table 1 the case in which the suspension contains compounds of monovalent copper, is shown as comparative example 1. The case in which use only phosphate-saline buffer, and used non-woven material, is shown as a control.

Table 1
Connection monovalent copperContent (wt.%)
Example 1-1Chloride copper (I)1
Example 1-2Chloride copper (I) 5
Example 1-3Iodide copper (I)5
Example 1-4Iodide copper (I)20
Example 1-5Iodide copper (I)40
Example 1-6The thiocyanate copper (I)20
Example 1-7The thiocyanate copper (I)40
Example 1-8The copper oxide (I)20
Example 1-9The copper oxide (I)40
Comparative example 1-
Standard(control)-

Evaluation of antiviral activity using hemagglutination.

Evaluation of the antiviral activity of the non-woven viscose material with the substrate of the compounds of monovalent copper was performed using hemagglutination. As a target used influenza virus (influenza A/Kita Kyushu/I 59/93 (H3N2), all grown is using MDCK cells. The titer of hemagglutination (titer) of influenza virus, brought into contact with the respective substances was determined by titration method.

In particular, the first was made of a series of two-fold dilution of sample in contact with a fragment of nonwoven material that secures the connection of monovalent copper, and phosphate-saline buffer. In each of the 96 wells round bottom plastic plate by injection was administered 50 μl of the dilution series. Then in each cell was added 50 ál of 0.5 vol.% suspension of chicken erythrocytes. Then the plate was left at 4°C for 60 min, and then visually observed sedimentation of erythrocytes. At this stage, as ON the title was adopted by a factor of the maximum dilution of the solution of the virus, which did not occur sedimentation of erythrocytes.

Solutions of samples were prepared as follows. Fragment of a non-woven fabric (40 mm×40 mm), which was fixed connection monovalent copper, finely cut by the cutter, and each of the cut pieces were placed in a vessel. In each of these vessels were added, respectively, in 1 ml of phosphate-saline buffer and 1 ml of influenza virus, the title of which was 256. After that, the obtained solutions with shaking in the rotator for microtubes interacted at room temperature for 10 minili 60 minutes Control sample was obtained by adding 450 μl of a solution of the virus titer, which was 256, 450 µl of phosphate-saline buffer and subsequent shaking in the rotator for micro test tubes for 10 minutes or 60 minutes Then the solutions of the samples recovered for each reaction time, and measured ON the title.

The results are shown in table 2.

Table 2
ON title
10 min60 min
Example 1-1<2<2
Example 1-2<2<2
Example 1-3168
Example 1-44<2
Example 1-5<2<2
Example 1-66432
Example 1-732 16
Example 1-85432
Example 1-9168
Comparative example 2126126
Standard126126

Example 2

Powder of copper chloride (commercially available compounds of monovalent copper, manufactured by Wako Pure Chemical Industries, Ltd., Wako Analytical Grade), crushed by a jet mill to an average particle size of approximately 5 μm and a grain of zirconium oxide (manufactured by Nippon Denko Co., Ltd., PCS), which contain methacryloxypropyltrimethoxysilane (obtained from Shin-Etsu Chemical Co., Ltd., KBM-503), which is a silane monomer with unsaturated position of binding covalently bound to their surface in a standard way a dehydration condensation, were dispersed in methanol. Then, to obtain a suspension containing particles of chloride monovalent copper with an average particle size of 60 nm, and zirconium oxide with an average particle size of 37 nm and methacryloxypropyltrimethoxysilane, chemically bonded with the surface, the resulting suspension was added methanol to the o to the concentration of solids to bring up to 5 wt.%. Used herein, the term "average particle size" refers to their average volume size.

The dosing amount of the particles of copper chloride (I) was chosen so that the solids content (in particular, particles of copper chloride (I)) on the substrate after the surface has been dried to remove solvent was 0.1 wt.% (example 2-1) or 1.0 wt.% (example 2-2) relative to the total content of Zirconia particles with associated methacryloxypropyltrimethoxy-silane and particles of copper chloride (I).

After that, the surface of polyester film having a thickness of 125 μm (manufactured by Toray Industries, Lumira) was subjected to hydrophilization by corona treatment. Then the film through the device for coating caused the suspension, and at 100°C for 5 min spent drying. After that, the tool with the coating was irradiated with 5 Mrad of electron beams at an accelerating voltage of 200 kV in order to obtain an antiviral agent.

Example 3

Antiviral agents of examples 3-1 and 3-2 was obtained as in example 2, except that instead of used in example 2, a polyester film was used non-woven material of nylon (Asahi Kasei Fibers Corporation, 1020) this non-woven material in the form of a coating applied suspensions of example 2 by immersion in it.

Example 4

Antiviral agent of example 4 was obtained in the same way as in example 2, except that the dosing amount of the particles of copper chloride (I) was chosen so that the solids content (in particular, particles of copper chloride (I)) on the substrate after the surface has been dried to remove solvent was 0.05 wt.% relative to the overall content of the Zirconia particles with their associated methacryloxypropyltrimethoxysilane and particles of copper chloride (I).

Example 5

Antiviral agents from example 5 was obtained in the same way as in example 2, except that instead of used in example 2 of copper chloride (I) was applied iodide copper (I), and that the content of solid substances (in particular, particles of copper iodide (I)) on the substrate was chosen comprising 20 wt.% (example 5-1) and 40 wt.% (example 5-2) relative to the total content of Zirconia particles with their associated methacryloxypropyltrimethoxysilane and particles of copper iodide (I).

Example 6

Antiviral agent of example 6 was obtained in the same way as in example 3, except that instead of used in example 3 chloride copper (I) was used thiocyanate copper (I), and that the content of solid substances (in particular, particles of copper thiocyanate (I)) on the substrate was chosen comprising 40 wt.%relative to the overall content of the Zirconia particles with associated methacrylate-propyltrimethoxysilane and particles thiocyanate copper (I).

Example 7

Antiviral agent of example 7 was obtained in the same way as in example 3, except that instead of used in example 2 chloride copper (I) used copper oxide (I), and that the content of solid substances (in particular, particles of copper oxide (I)) on the substrate was chosen comprising 40 wt.% relative to the overall content of the Zirconia particles with associated methacrylate-propyltrimethoxysilane and particles of copper oxide (I).

Comparative example 2

The polyester film used in example 2 was subjected to the treatment by corona discharge under the same conditions as in example 2, and this film was used for the evaluation of antiviral activity.

Comparative example 3

By crushing and dispersion of grains of zirconium oxide containing methacryloxypropyltrimethoxysilane (obtained from Shin-Etsu Chemical Co., Ltd., KBM-503)associated with their surface and used in example 2, was prepared by the suspension. In this process, used ball mill under the same conditions as in example 2. In order to bring the solids content to a value of 5 wt.%, she introduced methanol. The prepared suspension in the form of a coating was applied to the surface of the polyester film in order to obtain thin films of zirconium containing particles of copper chloride (I), the process was carried out at the same in the circumstances, as in example 2. The obtained thin film was used for the evaluation of antiviral activity.

Evaluation of antiviral activity according to the present invention.

Antiviral activity was assessed as antiviral activity against feline kalitsivirusa, which is usually used as the Deputy of the norovirus.

Each of the samples (in the form of a circle with diameter 10 cm) was placed in a sterilized Petri dish. On the periphery of the entire sample was fixed at the bottom of a Petri dish filled with an adhesive. In samples representing film (examples 2, 4, 5, comparative example 2 and comparative example 3) was added 6 ml cat kalitsivirusa, and in samples representing a fragment of a non-woven material (examples 3, 6 and 7), added 12 ml cat kalitsivirusa. Then the Petri dishes were subjected to shaking frequency of 200 rpm, the process was carried out at 25°C in a dark place.

Then gathered 100 µl sample solution, and to the end of the reaction was added 1800 µl of nutrient broth with a concentration of 20 mg/ml. After that, each sample was diluted in MEM diluent to a concentration of component 10-2-10-5(A 10-fold serial dilution). CrFK cells were inoculated with 100 µl of the sample solution after the reaction. After 90 min the absorbance of the virus on the cells was placed 0.7% of the environment and the Ara. Cell growth was continued for 48 h at 34°C incubator with 5% CO2. Cells were fixed by formalin and held staining with methylene blue. The infectivity titer of virus (PFU/0.1 ml, Log 10); (PFU: plaque-forming number) was calculated according to the number of the resulting hemolytic plaques. Have compared the activity of the virus with virus infectivity control sample.

Control sample

Control sample was obtained using a diluent MEM, which additionally did not enter the sample.

Table 3
Monovalent copperConcentration (wt.%)Contact time (min)Virus infectivity (PFU/0.1 ml, Log10)
Example 2-1Chloride copper (I)0,15<1
Example 2-2Chloride copper (I)1,05<1
Example 3-1Chloride copper (I)0,1 5<1
Example 3-2Chloride copper (I)1,05<1
Example 4Chloride copper (I)0,055is 3.08
Example 5-1Iodide copper (I)20,030<1
Iodide copper (I)20,060<1
Example 5-2Iodide copper (I)40,05<1
Iodide copper (I)40,010<1
Example 6The thiocyanate copper (I)40,060<1
Example 7The copper oxide (I)40,060 <1
Comparative example 155,00
Comparative example 2604,91
Comparative example 354,87
604,78
Control56,02
605,96

Based on the above results, all of the examples 2 through 7, which contain compounds of monovalent copper, in a short time was found to have a high inactivation, the value of which makes up 99% or higher. In particular, for examples 2, 3, 5, 6 and 7 were identified extremely high antiviral activity, amounting to 99.999% or higher. On the contrary, in comparative the examples 2 and 3 almost no antiviral action has not been demonstrated.

Used herein, the term "value inactivation" refers to a value determined by the formula

The magnitude of inactivation (%)=100×(10a-10b)/10a

in which

a: viral infectivity blank sample

b: the infectivity of the sample

Thus confirmed that the antiviral agent of the present invention has very high antiviral activity against as not having shell cat kalitsivirusa, and having the virus. So the patentable antiviral agent may be applied to various substrates, type of fibrous structure, films, sheets or molded articles, as it can provide a highly effective antiviral product.

Description of characters

100 antiviral agent

1 substrate

2 particle compounds of monovalent copper

3 inorganic particle

4 silane monomer

5 chemical bond between the substrate and celanova monomer

6 binding component

7 chemical bond between wilanowie monomers

8 chemical bonding between the inorganic particle and celanova monomer with a dehydration condensation

9 area for fixing the particles of compounds of monovalent copper

10 the group of inorganic particles.

1. About overuse means, contains:
substrate;
particles of compounds of monovalent copper; and
the group of inorganic particles, which serve for fixing to the substrate of these particles are compounds of monovalent copper containing silane monomer, chemically bonded to their surface, characterized in that the said inorganic particles containing on their surface a silane monomer, linked together by chemical bonds formed between wilanowie monomers on the surface of these inorganic particles, and the group of inorganic particles is connected with the substrate by chemical bonds between wilanowie monomers on the surface of the inorganic particles and the substrate,
moreover, the inorganic particles forms a zone for fixing particles of compounds of monovalent copper.

2. Antiviral agent containing:
coating the substrate with a slurry in which inorganic particles containing silane monomer with unsaturated position binding or reactive functional group chemically bound to their surface, and the particles monovalent copper compounds are dispersed, when this is done so that the inorganic particles with celanova the monomer chemically bound to their surface, were connected to each other through helices the relations between them, formed between these wilanowie monomers on the surface of the inorganic particles, and so that the group of inorganic particles with celanova the monomer chemically bound to their surface, was connected with the substrate chemical bonds formed between unsaturated position binding or reactive functional group Milanovich monomers and the surface of the substrate, forming a zone for fixing particles of compounds of monovalent copper, as well as pinning particles of compounds of monovalent copper in the specified area.

3. Antiviral agent according to claim 1, characterized in that the said chemical bond between wilanowie monomers and inorganic particles represent a covalent bond formed by dehydrogenation condensation, chemical communication between wilanowie monomers are covalent bonds formed by radical polymerization, and chemical bonds between wilanowie monomers and the substrate are covalent bonds formed by graft polymerization.

4. Antiviral agent according to claim 3, characterized in that the radical polymerization is an induced radiation radical polymerization, and the graft polymerization is the ow induced by radiation graft polymerization.

5. Antiviral agent according to claim 1, characterized in that the particles of the compounds of monovalent copper is connected with the above inorganic particles by a binder, which represents a monomer, oligomer, or a mixture.

6. Antiviral agent according to claim 1, characterized in that the particles of the compounds of monovalent copper formed by the chloride, acetate, sulfide, iodide, bromide, peroxide, oxide, hydroxide, cyanide, thiocyanate, or mixtures thereof.

7. Antiviral agent according to claim 1, characterized in that the particles of the compounds of monovalent copper is formed at one kind of compounds selected from the group consisting of CuCl, CuOOCCH3, CuI, CuBr, Cu2O, CuOH, Cu2S, CuCN and CuSCN.

8. Antiviral agent according to claim 1, characterized in that the particle content of the compounds of monovalent copper is from 0.1 to 60 wt.% the total content of solids on the substrate.

9. Antiviral agent according to claim 1, characterized in that the substrate is a fibrous structure.

10. Antiviral agent according to claim 2, characterized in that the said chemical bond between wilanowie monomers and inorganic particles represent a covalent bond formed by dehydrogenation condensation, chemical bonding between wilanowie monomers are covalent bonds, formed by radical polymerization, and chemical bonds between wilanowie monomers and the substrate are covalent bonds formed by graft polymerization.

11. Antiviral agent according to claim 10, characterized in that the radical polymerization is an induced radiation radical polymerization, and the graft polymerization is a induced by radiation graft polymerization.

12. Antiviral agent according to claim 2, characterized in that the particles of the compounds of monovalent copper is connected with the above inorganic particles by a binder, which represents a monomer, oligomer, or a mixture.

13. Antiviral agent according to claim 2, characterized in that the particles of the compounds of monovalent copper formed by the chloride, acetate, sulfide, iodide, bromide, peroxide, oxide, hydroxide, cyanide, thiocyanate, or mixtures thereof.

14. Antiviral agent according to claim 2, characterized in that the particles of the compounds of monovalent copper is formed at one kind of compounds selected from the group consisting of CuCl, CuOOCCH3, CuI, CuBr, Cu2O, CuOH, Cu2S, CuCN and CuSCN.

15. Antiviral agent according to claim 2, characterized in that the particle content of the connection odnov entei of copper is from 0.1 to 60 wt.% the total content of solids on the substrate.

16. Antiviral agent according to claim 2, characterized in that the substrate is a fibrous structure.



 

Same patents:
Hygienic handwash // 2495658

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical and cosmetic industry and represents a hygienic handwash, preferentially before using contact lenses. The hygienic handwash contains ethanol, glycerol, 1,2-propylene glycol, Pherol A, Aloe Vera extract, a flavour and water; as an antibacterial additive, the product contains polyhexamethylene biguanidine hydrochloride, while a moisturising supplement - KM-25 (water/propylene glycol extract of glucomannan) in the following proportions, wt %: Rectified ethanol 56.0-65.0; Glycerol 0.6-2.0; 1,2-propylene glycol 0.7-1.2; KM-25 (water/propylene glycol extract of glucomannan) 0.009-0.012: Pherol A 0.009-0.015; Aloe Vera extract 0.008-0.02; Flvour 0.05-0.07; Polyhexamethylene biguanidine hydrochloride 0.1-0.5; Water - up to 100%.

EFFECT: invention provides developing a product for effective hand protection and cleansing.

2 cl, 1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to a method for preparing an immobilised 1,2-benzisothiazolin-3-one complex, an antimicrobial composition containing it and to using the above composition as an antimicrobial agent. The immobilised 1,2-benzisothiazolin-3-one is prepared by heating 1,2-benzisothiazolin-3-one and zinc chloride brought to the boiling point with partial condensation in C1-C4 alcohol to prepare a solution to be cooled and added with the immobilising effective amount of zinc oxide. The prepared mixture is brought to the boiling point with partial condensation, cooled to room temperature and filtered to prepare the immobilised 1,2 - benzisothiazolin-3-one/zinc oxide complex.

EFFECT: declared inventions provide producing the antimicrobial immobilised 1,2 - benzisothiazolin-3-one/zinc oxide complexes applicable as preserving agents due to their wash-out resistance.

12 cl, 4 dwg, 2 tbl, 22 ex

Disinfectant // 2490008

FIELD: medicine.

SUBSTANCE: disinfectant refers to veterinary medicine, particularly to disinfectants used for air sanitation and surface disinfection in livestock houses in the presence of animals, including poultry. The agent has an antiseptic effect, which allows using it in acute, chronic and sub-clinical mastitis, vaginitis, endometritis and other inflammatory processes of varying aetiology. An active ingredient is presented by a complex of dimethyl sulphoxide and crystalline iodine, succinic acid, fumaric and citric acids which provides better drug absorption and prolonged action. It is prepared in the form of mother liquor diluted in water immediately before use.

EFFECT: invention enables prolonging the shelf life when in use.

7 tbl

FIELD: chemistry.

SUBSTANCE: method of producing a disinfectant involves first carrying out polycondensation of hexamethylenediamine and guanidine hydrochloride. Polycondensation starts with preparation of a reaction mass in form of a suspension of crystalline guanidine hydrochloride in molten hexamethylenediamine, taken in ratio of 1:(1-1.5). The suspension is obtained by gradually adding crystalline guanidine hydrochloride, preheated to temperature of 90-120°C, to molten hexamethylenediamine and then stirring. The reaction mass is then heated in steps: holding for 4 hours at 120°C, then for 8 hours at 160°C and then for 3 hours at 180°C. Temperature is then gradually raised to 210°C at a rate of 3-4°C/h. The reaction mass is then subjected to vacuum treatment and cooled.

EFFECT: method enables to reduce toxicity of the end product and obtain a polymer with the required molecular weight and sufficient purity without washing steps.

2 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture and is meant for disinfecting vehicles and containers after transporting livestock cargo. The method involves treating vehicles and containers with a disinfectant. The disinfectant contains a solution of oxidants and additionally propylene glycol, sodium nitrite, sodium benzoate, products of reaction of glycerol with formic acid, with the following ratio of components, wt %: propylene glycol - 0.9-7.5, sodium nitrite - 0.27×10-3-16.5×10-3, sodium benzoate - 1.35×10-3-82.5×10-3, products of reaction of glycerol with formic acid - 0.18×10-3-11.0×10-3, solution of oxidants - the balance. The solution of oxidants is synthesised from 10.0-20.0% sodium chloride solution subjected to dc current with intensity which enables to achieve pH 7-8, concentration of active chlorine of 0.5-0.7% and redox potential of +1000±50 mV. Treatment is carried out once with consumption of the disinfectant of 0.15-0.25 l/m2 with exposure of 55-65 min; immediately after treating with the disinfectant, the surface of the vehicles and containers is further exposed for 30-60 min with constant UV radiation with wavelength of 254±5 nm with a dose of 12.8-25.6 J/cm2.

EFFECT: high efficiency of disinfecting vehicles and containers after transporting livestock cargo.

4 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to disinfectants. An antiseptic disinfectant contains the film-forming preparation iodopyrone containing 6-8% of active iodine and water, contains ethanol in the following proportions, wt %: iodopyrone - 1.0-1.3 (per active iodine basis), ethanol - 20, water - the rest. The antiseptic disinfectant represents a ready-to-use preparation presented in the form of a solution or a spray.

EFFECT: invention provides the qualitative and quantitative stability of the active substance in the easily water-washable disinfectant which does not stain and has a non-irritant, prolonged effect If kept in an unopened container, it has a shelf-life of 2 years from the date of manufacture.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to bactericidal medication and can be applied for disinfection of livestock premises, placed in them technological equipment, implements for animal care, vehicles for transportation of animals, places where animals and other objects of veterinary supervision are concentrated. Medication includes alkyldimethylbenzylammonium chloride (ADMBAC), glutaric aldehyde, water and sodium hydroxide, taken in specified ratio. In case of specified ratio synergetic effect is observed and maximal bactericidal activity of medication, assessed by value of minimal bactericidal concentration (MBC), at which death of test-culture is observed, is reached.

EFFECT: invention ensures increase of bactericidal activity and reduction of medication toxicity with minimal content of active substances.

1 tbl, 15 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a composite material which contains a non-organic substance in the form of a layer or a layer ingredient with the non-organic substance leads to form hydrogen cations in contact with an aqueous medium that induces an antimicrobial effect with the substance being produced of MoO2, MoO3, molybdenum carbide, molybdenum nitride, molybdenum silicide, molybdenum sulphide, molybdenum hexacarbonyl and/or molybdenum acetylacetonate.

EFFECT: antimicrobial effect of the composite material is found through time almost with no limit.

32 cl, 3 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to materials and methods for elimination of live target-cells. Material for elimination of live target-cells contains, at least, one insoluble hydrophobic anionic, cationic or amphoteric charged polymer. Said polymer in contact with water-containing environment: a) is a carrier of strongly acidic or strongly basic functional group; b) has pH value lower than 4.5 or higher than 8.0 and c) possesses proton conductivity and/or electric potential, sufficient for efficient disturbance of pH homeostasis and/or electric balance inside closed volume of said cell. Said charged polymer preserves pH value of medium, surrounding said cells. Said material can be regenerated by regeneration of charged polymer, regeneration of buffer capacity of said material, regeneration of proton conductivity of said material. Manufactured product contains said material.

EFFECT: invention makes it possible to regenerate said purpose.

18 cl, 23 dwg, 9 tbl, 14 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfection. The composition contains hydrogen peroxide and an aqueous solution of copper or one of its derivatives, such as copper salts, as well as at least one salt of an anionic surfactant inhibiting decomposition of hydrogen peroxide in the presence of copper. The composition may be prepared immediately before use by mixing the aqueous solution of copper and the aqueous solution of hydrogen peroxide.

EFFECT: invention provides simultaneous disinfection and decontamination of the objects infected by special infectious agents (NCTA), such as prions, and common infectious agents (CTA), such as bacteria, yeast, viruses, mould spores, mycobacteria, bacterial spores.

23 cl, 5 tbl

FIELD: medicine.

SUBSTANCE: invention refers to public health, veterinary science, food processing, pharmaceutical and biotechnological productions. Disinfection objects are processed by the system of disinfectants consisting of at least two preparations, wherein at least one of the preparations is specified in a group of oxidants, namely oxygen-chlorine substances, and at least one of the preparations is specified in a group of non-oxidants, including, QACs - quaternary ammonium compounds, tertiary amines, aldehydes, guanidines. The system of disinfectants is packed within a package so that each preparation is placed separately, and each following preparation is used only after the previous preparation has been consumed completely.

EFFECT: invention provides the controlled rotation of disinfectants that prevents the developing acquired microorganism resistance.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly to stabilised aqueous antimicrobial compositions. The antimicrobial composition contains 2-25 wt % of 2,2-dibrom-3-nitrilopropionamide, 5-30 wt % of an aliphatic compound containing 2 to 6 hydroxyl groups, 20-70 wt % of ethylene glycol, 2-30 wt % of water.

EFFECT: invention provides stability and low viscosity of the composition.

10 cl, 5 ex

Disinfectant // 2481126

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

Disinfectant // 2481126

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

FIELD: chemistry.

SUBSTANCE: group of inventions relates to disinfection and sterilisation. The acidic liquid composition used is a liquid composition which contains (a) an acidic oxidant, (b) nitric acid or salt thereof and (c) at least one carboxylic acid selected from a group consisting of monocarboxylic acids, dicarboxylic acids and tricarboxylic acids, or salt thereof. In the disinfection and sterilisation method, the acidic liquid composition contains an acidic oxidant having an excellent corrosion inhibiting property (property of preventing rust, property of inhibiting formation of an oxide film) for aluminium-based metals even in acidic conditions, without affecting the appearance or function of such metals.

EFFECT: efficiently used to disinfect or sterilise an object having a part made from aluminium-based metals.

12 cl, 20 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to disinfectants. An antiseptic disinfectant contains the film-forming preparation iodopyrone containing 6-8% of active iodine and water, contains ethanol in the following proportions, wt %: iodopyrone - 1.0-1.3 (per active iodine basis), ethanol - 20, water - the rest. The antiseptic disinfectant represents a ready-to-use preparation presented in the form of a solution or a spray.

EFFECT: invention provides the qualitative and quantitative stability of the active substance in the easily water-washable disinfectant which does not stain and has a non-irritant, prolonged effect If kept in an unopened container, it has a shelf-life of 2 years from the date of manufacture.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to bactericidal medication and can be applied for disinfection of livestock premises, placed in them technological equipment, implements for animal care, vehicles for transportation of animals, places where animals and other objects of veterinary supervision are concentrated. Medication includes alkyldimethylbenzylammonium chloride (ADMBAC), glutaric aldehyde, water and sodium hydroxide, taken in specified ratio. In case of specified ratio synergetic effect is observed and maximal bactericidal activity of medication, assessed by value of minimal bactericidal concentration (MBC), at which death of test-culture is observed, is reached.

EFFECT: invention ensures increase of bactericidal activity and reduction of medication toxicity with minimal content of active substances.

1 tbl, 15 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to using derivatives of dithiocarbamate of the formula: R1R2NCS2H and oxidized forms of these compounds, in particular, their dimmers and their pharmaceutically compatible salts for preparing an agent used in treatment or prophylaxis of infection caused by RNA-containing viruses that damage respiratory tract and inducing disease. Also, invention relates to a disinfecting agent containing dithiocarbamate compound and a method for disinfection of surfaces, media and cell cultures.

EFFECT: valuable medicinal properties of compounds.

19 cl, 14 dwg, 14 ex

Up!