Composition for disinfection and decontamination of objects infected by prions, and also other infectious agents

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfection. The composition contains hydrogen peroxide and an aqueous solution of copper or one of its derivatives, such as copper salts, as well as at least one salt of an anionic surfactant inhibiting decomposition of hydrogen peroxide in the presence of copper. The composition may be prepared immediately before use by mixing the aqueous solution of copper and the aqueous solution of hydrogen peroxide.

EFFECT: invention provides simultaneous disinfection and decontamination of the objects infected by special infectious agents (NCTA), such as prions, and common infectious agents (CTA), such as bacteria, yeast, viruses, mould spores, mycobacteria, bacterial spores.

23 cl, 5 tbl

 

The present invention relates to compositions for the simultaneous disinfection and decontamination of objects of the environment, contaminated conventional infectious agents (CTA), in particular, such as bacteria, yeast, mold fungus spores, bacterial spores, viruses, and specific infectious agents (NCTA), such as prions.

The invention is intended in particular for processing heat-sensitive items such as endoscopes.

If there is a suspected infection of a subject, reusable regular or special infectious agents, it is recommended:

- destroy it by burning, if it allows the economic situation, and otherwise

- sterilized using steam (autoclaving), if it is heat-resistant, if not

- to expose its so-called processing, disinfection and/or decontamination. The present invention concerns primarily the third situation, when the subject is, in particular, heat-sensitive and is designed to be reusable.

The subject may be infected with pathogens HUNDRED or NCTA resulting from the use of this object with internal or external contact with the body. An example of the use of endoscopic equipment during medical research. When contact is by some authorities and/or human or animal fluids can be infected NCTA, and at the same time a HUNDRED.

Between the two studies in two different patients are recommended to carry out operations designed to reduce the risk of infection by pathogens NCTA or a HUNDRED.

Currently there is no simple and effective way, which would simultaneously disinfect against one HUNDRED and decontamination against the NCTA for heat-sensitive and sensitive to alkaline pH of reusable items.

A known method of disinfection of heat-sensitive items reusable by immersion in a disinfectant solution. There is also known a method of decontamination of objects against the NCTA by immersion in a disinfectant solution when the pH from alkaline to strongly alkaline (sodium hydroxide solution or potassium hydroxide or polyetheramine with a pH from 10 to 14). Today not apply way immersion, which allows the decontamination of objects from NCTA, sensitive to alkaline pH.

However, from the document WO 2005/118762 know the use of copper and its derivatives for the decontamination of objects contaminated with prions. Preferably the processing decontamination produce a solution containing specified compound in an amount of not less than 500 micromoles of metal derivatives. This solution may contain TRANS is CIS hydrogen (H 2About2in the solution at a ratio of approximately 50 mm.

This composition allows the decontamination of objects contaminated with prions, but given the small number of N2About2prevents disinfect against pathogens HUNDRED, in particular, such as bacteria, yeast, viruses and so on, with efficiency, the relevant European standards (see standard EN 14561, EN 14562, EN 14563, EN 14476...).

Extremely difficult to identify the risk of infection by pathogens NCTA. To determine the degree of risk is possible only by means of visible symptoms or medical card of the patient. In order to limit any risk of cross-contamination, it is desirable to systematically produce decontamination of any object that may be contaminated with pathogens NCTA.

To facilitate the operation of decontamination and make it compatible with the methods of cleaning and disinfection of the objects, the present invention is the provision of decontamination against NCTA time with regular cleaning and disinfection.

In particular, the present invention is to provide a composition for simultaneous disinfection and decontamination of objects contaminated conventional infectious agents (STA), and specific infectious agents (NCTA), such as prions.

p> The invention also aims to propose such a composition, particularly adapted for manual processing, in particular by immersion.

The invention also aims to propose a method of obtaining such a composition of the two solutions, respectively, based on copper and on the basis of hydrogen peroxide.

The invention also seeks to provide an aqueous solution of copper, which help to quickly obtain a composition in accordance with the present invention, by mixing with the aqueous hydrogen peroxide solution.

The invention also seeks to provide an aqueous hydrogen peroxide solution, designed for mixing with an aqueous solution of copper to obtain a composition in accordance with the present invention.

Other objectives and advantages of the present invention will be more apparent from the following description, provided solely as a non-restrictive example.

The object of the present invention is a composition for simultaneous disinfection and decontamination of objects contaminated conventional infectious agents (CTA), in particular, such as bacteria, yeast, mold fungus spores, bacterial spores, viruses, and specific infectious agents (NCTA), such as prions, in particular, for processing heat-sensitive items such as endoscopes.

According to the SNO invention, this composition contains hydrogen peroxide solution and an aqueous solution of copper or one of its derivatives, such as salt of copper, and at least one converted into a salt anionic surfactant, inhibiting the decomposition of hydrogen peroxide in the presence of copper.

The object of the invention is also an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution to obtain a composition in accordance with the present invention.

An aqueous solution of copper in accordance with the present invention contains at least one converted into a salt anionic surfactant, inhibiting the decomposition of hydrogen peroxide in the presence of copper.

The object of the invention is also an aqueous solution of hydrogen peroxide, used for mixing with an aqueous solution of copper to obtain a composition in accordance with the present invention.

An aqueous solution of hydrogen peroxide in accordance with the present invention contains stabilizers of hydrogen peroxide selected from phosphonates, perborates, with a content of from 0.002 wt.% to 0.07 wt.%.

The object of the invention is also a method of obtaining a composition in accordance with the present invention, according to which, immediately prior to use mixed aqueous solution of copper and water, R is the target of hydrogen peroxide.

The object of the invention is also the use of a composition in accordance with the present invention and/or an aqueous solution of copper mixed with hydrogen peroxide solution for the simultaneous disinfection and decontamination of objects contaminated with pathogens HUNDRED, in particular, such as bacteria, yeast, etc. and pathogens NCTA, such as prions.

The invention will be better understood from the following description.

Set the activity of some metals, particularly copper, is used as a salt, to effectively kill pathogenic factors of type specific infectious agents. Performance against these pathogens can be increased in the presence of peroxy compounds, in particular hydrogen peroxide. Unfortunately, these two compounds have a very high mutual affinity: salt of copper, such as copper sulfate, is restoring the connection, while hydrogen peroxide is a powerful oxidizer.

In order to provide standards for evaluation of biocidal activity against a HUNDRED, for the time periods allowed in medical and industrial practice, the peroxide is used in high concentrations. The concentration of hydrogen peroxide may range from 1 to 10% depending on the time steps. In the case of this method, in order to meet the substance of the existing practice in health and industry, require short time periods from 10 to 30 minutes, the most appropriate concentration of hydrogen peroxide may be a concentration of from about 6.5 to 8.5 per cent. This high concentration of oxidizing agent increases the incompatibility oxidizing agent/reducing agent in combination hydrogen peroxide/salt of copper.

The present invention is to achieve compatibility and the use of these reducing and oxidizing compounds, which are inherently incompatible between themselves in order to maintain the overall effectiveness of disinfection and decontamination against the NCTA and a HUNDRED.

Simple mixing of salts of copper and hydrogen peroxide leads to almost instantaneous decomposition of peroxides with oxygen. To offer an acceptable way at least the minimum period of stability and, therefore, the sale should, for example, to put these two connections to two different vessel. However, this solution is not enough, because the task of ensuring the stability, i.e. the use of the solution after mixing the contents of containers, containing, respectively, an aqueous solution of copper and hydrogen peroxide solution.

Implementation by simple mixing will lead to the specified decay begins immediately and ends with a partial and then a full decomposition of the peroxide is hydrogen: such mixing leads first to a partial and then to a complete loss of effectiveness against pathogens and NCTA HUNDRED, as shown in table 1.

Table 1
Stability of hydrogen peroxide in the presence of copper sulfate
T0T=15 minT=24 hoursT=72 hours
The concentration of H2O2(weight)7,5%7,4%2,62%0,37%
Table 1B
Comparative activity of hydrogen peroxide, copper salts, and mixtures according to the invention according to standard EN 13727 against Staphylococcus aureus
H2O27,5%CuSO4(0.5 m)The mixture according to the invention
T=30 minT=24 hT=72 hT=7 days
Staphylococcus aureusActive >5 logIneffectiveActive >5 logActive >5 logIneffectiveIneffective

The use of certain compounds, converted into a salt, soda and potash, among them Las sodium, alkylarylsulfonate sodium, alkylsulfate sodium, prevents decomposition reaction of hydrogen peroxide with copper salts. As shown in table 2, the choice of a particular compound and its amount are of paramount importance in the regulation of the interaction between the two ingredients. Alkylsulfate and alkylarylsulfonate sodium are, in particular, the two salts having good characteristics. In particular, we evaluated C12-alkyl chain.

7,6%
Table 2
Stability of hydrogen peroxide in the presence of copper salts, depending on the concentration (wt.%) anionic ingredient/td>
Data +/- 0.1%The concentration of the anionic ingredientsT0T=15 minT=24 hT=72 h
Alkylarylsulfonate sodium0,1%7,6%7,6%7,3%6,9%
1%7,6%7,6%7,6%7.6%
Las sodium0,1%7,6%7,6%7,4%7,3%
1%7,5%7,5%7,5%7,5%
Alkyl(dodecyl)sulfate sodium0,1%7,6%7,6%7,6%7,4%
1%7,6%7,6%7,6%

Thus, the present invention relates to a composition for simultaneous disinfection and decontamination of objects contaminated conventional infectious agents (CTA), in particular, such as bacteria, yeast, mold fungus spores, bacterial spores, viruses, and common infectious agents (NCTA), such as prions, in particular, for processing heat-sensitive items such as endoscopes.

Under the subject in this case it is necessary to understand any subject, in particular, heat-sensitive and designed to be reusable, or any surface, in particular, such as the floor or a Mat.

According to the invention, the composition comprises a solution of hydrogen peroxide and an aqueous solution of copper or one of its derivatives, such as a salt of copper, and at least one salt of anionic surfactants, inhibitory decomposition of hydrogen peroxide in the presence of copper.

According to a variant implementation, the composition may contain (wt.%):

- dehydrated salts of copper 0.005% to 0.01%,

- hydrogen peroxide from 5% to 9%,

- salt anionic surfactant from 0.5% to 1.5%,

- demineralized water in sufficient quantity to 100%,

the amount of ingredients equal to 100%.

To give a composition with bactericidal properties, not wkhuds is I its ability to inactivate prions, the hydrogen peroxide concentration should be between 5 wt.% up to 9 wt.%.

Mentioned, at least one salt of the anionic surfactant can be selected from the following group (not restrictive):

dodecylbenzensulfonate, dodecyl sulphate, dodecylsulfate sodium.

Purity anionic salts is of great importance for the stability of the oxidizing agent that is derived from table 3.

Table 3
Stability of hydrogen peroxide in the presence of copper salts, depending on the purity anionic salts
T0T=15 minT=24 hours
Industrial qualityof 7.5%(+/-0.1)7,3%(+/-0.1)7,2%(+/-0.1)
A high degree of purity (synthesis)of 7.5%(+/-0.1)of 7.5%(+/-0.1)of 7.5%(+/-0.1)

Preferably, the aforementioned at least one salt anionic surfactant must be ultrapure, that is, to have a so-called synthetic quality.

The instability of copper salts may be expressed in the emergence of sieges is at the boundary of the air/solution mixture of a solution of copper and hydrogen peroxide solution. At the beginning of the appearance of the precipitate, the presence of salts, in particular salts of calcium and magnesium in the water (water) for washing items after cleaning and before immersion in the composition leads to an increase in these sediments, which may complicate the treatment of subjects with channels of small diameter.

The presence of copper salts may require optimization of their solubility, in particular, with oxidizing agents. The insolubility or partial solubility of copper salts is compounded by the salts of calcium and magnesium present in the water to wash items after cleaning and before immersion in the composition. Ingredients type alkylpolyglucoside in the appropriate quantity and quality can be effective, particularly when they are added in proportions selected according to the number of carbon atoms in the alkyl chains. According to a variant implementation, the composition may also contain specially selected surfactants of the type polyglucoside fatty alcohols, in particular, such as C4-alkali, for the dissolution of copper salts.

Using alkylpolyglucosides in a solution of copper with a large number of anionic salts for the dissolution of copper salts in the presence of, in particular, salts of calcium, magnesium and others leads to the phenomenon of instability and phase shift due to oversaturation. To solve these problems liberaltarian, in particular, girotropnye reagents, in particular, the type of toluensulfonate or cellsurface sodium.

Table 4
The presence of sediment, depending on the presence of compounds of the type alkylpolyglucosides
T0T=24 hoursT=7 days
A solution of H2O2+ salt Cu + anionic derivativesnoYesYes
A solution of H2O2+ salt Cu + anionic derivatives + alkylpolyglucosidenonono

The addition compounds of the type alkoxylate fatty alcohol chosen by their hydrophilic-lipophilic balance, in combination with the third solvent type of alcohol with the number of carbon atoms, in particular from 4 to 6, suitable for this complex mixture, can help improve balance, which ensures the stability in time, in particular, at low temperatures from +5C to 35C. the Composition may contain a surface-active polyalkoxy fatty Speer is s, which provide hydrotropes, in combination with the third solvent type of alcohol or a polyhydric alcohol, contributing, in particular, the stability at low temperatures.

Might want to use a dye to distinguish the composition from another solution, which can be used in the performance of the same work. The choice of dye must be made carefully, as it should for some time, in particular, a few days to be present in the composition, in particular, after mixing of the solution based on copper and hydrogen peroxide solution, the oxidizing agents which is known for its bleaching properties. A good compromise may be blue triarylmethane dye: it stains the solution with satisfactory stability over time, but does not stain the treated objects.

According to a variant implementation, the composition may contain (wt.%):

salts of copper, 0.005% to 0.01%,

- hydrogen peroxide from 5% to 9%,

- salt anionic surfactant from 0.5% to 1.5%,

- surfactant type polyglucosides fatty alcohol is from 0.1% to 0.4%,

- surface-active polyalkoxyalkyl fatty alcohol is from 0.1% to 0.3%,

the third solvent such as alcohols or polyhydric alcohols of from 0.1% to 0.3%,

- dye in sufficient is Alceste,

- demineralized water in sufficient quantity to 100%,

the amount of ingredients equal to 100%.

The object of the invention is also a method of obtaining a composition in accordance with the present invention, according to which, immediately prior to use mixed aqueous solution of copper and an aqueous solution of hydrogen peroxide.

Specified aqueous solution of copper can be added to a solution of peroxides in the appropriate proportions, for example, 1/25.

According to a variant of execution, an aqueous solution of copper, intended for mixing with the aqueous peroxide solution may optionally contain at least one salt of anionic surfactants, inhibiting the decomposition of hydrogen peroxide in the presence of copper.

Turned salt anionic surfactant can be selected from the following group: dodecylbenzensulfonate, dodecyl sulphate, dodecylsulfate sodium content of 1 to 50%, in particular from 20 to 30%.

According to the exemplary embodiment, surface-active agent is dodecyl sulphate or dodecylsulfate sodium content of from 20 to 30 wt.%, that allows to obtain a final concentration of about 1% in the composition according to the invention.

Mentioned, at least one salt anionic surfactant must be ultra-pure and to have the so-called this is the definition of quality, in particular, almost not contain impurities and other residues of synthesis, which can catalyze the decomposition, including peroxides.

An aqueous solution of copper may contain at least one surfactant type polyglucosides fatty alcohol to dissolve the salts of copper with a content of from 2.5 to 10 wt.%, what, in particular, provides the ultimate concentration in the claimed composition from about 0.1 to 0.4%.

An aqueous solution of copper may contain at least one surfactant type polyalkoxy fatty alcohol to stabilize the composition with a content of from 2.5 to 7.5 wt.%, what, in particular, provides the ultimate concentration in the claimed composition from about 0.1 to 0.3%.

An aqueous solution of copper may contain salt copper sulfate in an amount of from 0.1 wt.% to 0.25 wt.%, what, in particular, provides the ultimate concentration in the claimed compositions is approximately 0.005 to 0.01%.

An aqueous solution of copper may contain third solvent type of alcohol or a polyhydric alcohol with a content of from 2 to 10%, in particular from 4 to 7%.

An aqueous solution of copper may contain a dye, in particular, a blue dye type triarylmethane compatible with metal salts and hydrogen peroxide.

An aqueous solution of copper may contain (wt.%):

salts of copper, from 0.1% to 0.25%,

- salt is nianogo surfactants from 20% to 30%,

- surfactant type polyglucosides fatty alcohol from 2.5% to 10%,

- surface-active polyalkoxyalkyl fatty alcohol from 2.5% to 7.5%,

the third solvent such as alcohols or polyhydric alcohols from 4% to 7%,

- dye in sufficient quantities,

- demineralized water in sufficient quantity to 100%,

the amount of ingredients equal to 100%.

This solution of copper can be added to a solution of peroxides in the appropriate proportions, for example, 1/25.

The object of the invention is also an aqueous solution of hydrogen peroxide, used for mixing with an aqueous solution of copper, in particular, described above, to obtain a composition in accordance with the present invention.

Solutions of oxidizing agents are particularly unstable in the presence of metal salts. Therefore, it is preferable to protect these oxidizing solutions, on the one hand, due to the high analytical quality, and, on the other hand, by adding phosphonates, persona sodium or potassium. The addition should be performed only in a quantity sufficient to neutralize any mineral or metal compounds, undesirable in a separate aqueous solution of hydrogen peroxide or a mixture of an aqueous solution of copper-based.

According to the invention, the hydrogen peroxide content is t stabilizers of hydrogen peroxide, selected from phosphonates, perborates, in the amount of from 0.002 wt.% to 0.07 wt.%.

As can be seen from table 5, the activity against many microorganisms according to EN 13727, EN 13624 above for compositions in accordance with the present invention in comparison with a solution of hydrogen peroxide and copper sulfate solution used separately.

Table 5
Comparison of activity after 15 min after mixing according to the norms EN 13727 (decrease microbial population 5 log 5 min) and EN 13624 (reduction of microbial populations on 4 log for 15 min at +20 C
Pseudomonas aeruginosaEN 13727Candida albicans EN 13624
% Aqueous solution of copper (by volume)Bactericidal activity% Aqueous solution of copper (by volume)Bactericidal activity
The hydrogen peroxide solution + copper sulphate solution separately20%<4 log20%<2.7 log
40% >5.4 log40%>4 log

Assessed the impact of each ingredient solution of copper and hydrogen peroxide solution from the point of view of the activity towards the pathogens NCTA. At each stage of the development of the composition were measured efficiency by Western Blot method.

In General, the method of processing items assessing the effectiveness of the composition produced in vitro in relation to NCTA according to known methods (Western Blot), at least six different strains and in vivo in animals infected with infectious brain inoculum.

The composition in accordance with the present invention, in particular containing a hydrogen peroxide solution, mixed with an aqueous solution of copper finds its application for the simultaneous disinfection and decontamination of objects contaminated with pathogens HUNDRED, such as bacteria, yeast, spores, viruses and other, and pathogens NCTA, such as prions. The method may include the preliminary step of cleaning and/or disinfection for partial physical and/or enzymatic removal of particles of a HUNDRED or NCTA.

In particular, the method may include the first stage application of detergent and/or disinfectant detergent, enzyme or no enzyme that can remove a significant portion of Sarai the frame of the substance, quantitatively defined by the above methods in vitro and in vivo. In the second stage, repeat the first operation within more or less the equivalent time, then on the third stage we use the composition in accordance with the present invention. This method provides effectiveness against pathogens NCTA and effectiveness against pathogens HUNDRED confirmed existing and recognized methods of measuring the effectiveness of disinfectants.

Naturally, the specialist may provide other ways to perform, without leaving the scope of the invention defined below formula inventions

1. The use of a composition for the simultaneous disinfection and decontamination of objects contaminated with prions and conventional infectious agents (CTA), such as bacteria, yeast, viruses, mould spores, microbacteria, bacterial spores, containing a solution of hydrogen peroxide and water raspor copper or one of its derivatives, such as salts of copper, and at least one salt of anionic surfactants, inhibiting the decomposition of hydrogen peroxide in the presence of copper, in which the hydrogen peroxide concentration is from 5% to 9 wt.%.

2. The use according to claim 1, wherein the specified composition comprises (in wt.%):
- dehydrated salt is the only 0.005% to 0.01%,
- hydrogen peroxide from 5% to 9%,
- salt anionic surfactant from 0.5% to 1.5%,
- demineralized water in sufficient quantity to 100%, with the amount of ingredients equal to 100%.

3. The use according to claim 1, wherein the specified at least one anionic surfactant selected from the following group: dodecylbenzensulfonate, dodecyl sulphate, dodecylsulfate sodium.

4. The use according to claim 1, wherein the specified at least one salt of the anionic surfactant is ultra clean and has a synthetic quality.

5. The use according to claim 1, wherein the composition comprises a surfactant type polyglucoside fatty alcohols, in particular C4-alkali, for the dissolution of copper salts.

6. The use according to claim 5, wherein the specified composition contains a surface-active polyalkoxy fatty alcohols, providing hydrotropes, in combination with solubilizers agent such as alcohols or polyols.

7. The use according to claim 1, wherein the specified composition contains a dye that is compatible with metal salts and hydrogen peroxide.

8. The use according to claim 1, wherein the composition comprises (in wt.%):
salts of copper, 0.005% to 0.01%,
- hydrogen peroxide from 5% to 9%,
- salt anionic surfactant from 0.5% to 1.5%,
- p is supercial-active substances such polyglucosides fatty alcohol is from 0.1% to 0.4%,
- surface-active polyalkoxyalkyl fatty alcohol is from 0.1% to 0.3%,
- solubilizers agent such as alcohols or polyhydric alcohols of from 0.1% to 0.3%,
- dye in sufficient quantity,
water in sufficient quantity to 100%, with the amount of ingredients equal to 100%.

9. The use according to claim 1, wherein the specified composition can be prepared immediately before use by mixing an aqueous solution of copper and an aqueous solution of hydrogen peroxide.

10. The use according to claim 9, wherein the specified aqueous solution of copper, intended for mixing with the aqueous peroxide solution additionally contains at least one salt of anionic surfactants, inhibitory decomposition of hydrogen peroxide in the presence of copper.

11. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt of the anionic surfactant and the contents of the specified salt anionic surfactant in the specified aqueous solution of copper is from 1 to 50% (wt.%).

12. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt of anionic surface-active what about the substances in quantities of 1 to 50 wt.% and this aqueous solution of copper in an amount of from 0.1 wt.% to 0.25 wt.%.

13. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant, selected from the following group: dodecylbenzensulfonate, dodecyl sulphate, dodecylsulfate sodium.

14. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant, which is ultra-pure and has a synthetic quality.

15. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant and an aqueous solution of copper contains at least one surfactant type polyglucosides fatty alcohol to dissolve the salts of copper with a content of from 2.5 to 10 wt.%.

16. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant and an aqueous solution of copper contains surface-active polyalkoxy fatty JV shall mouths to ensure hydrotropes content from 2.5 to 7.5 wt.%.

17. The use of claim 10, wherein the aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant and an aqueous solution of copper contains polyalkoxy fatty alcohols, providing hydrotropes in the amount of from 2.5 to 10 wt.%, and wherein the aqueous solution contains copper solubilizers agent type of alcohol or a polyhydric alcohol content of 4 to 7 wt.%.

18. The use according to claim 9, in which an aqueous solution of copper, intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant and an aqueous solution of copper contains a dye that is compatible with metal salts and hydrogen peroxide.

19. The use according to claim 9, in which an aqueous solution of copper intended for mixing with the aqueous hydrogen peroxide solution additionally contains at least one salt anionic surfactant and an aqueous solution of copper contains (in wt.%):
salts of copper, from 0.1% to 0.25%,
- salt anionic surfactant from 20% to 30%,
- surfactant type polyglucosides fatty alcohol from 2.5% to 10%,
- surface-active polyalkoxyalkyl fatty alcohol from 2.5% to 7.5%,
with obelisonugi agent such as alcohols or polyhydric alcohols from 4% to 7%,
- dye in sufficient quantity,
- demineralized water in sufficient quantity to 100%, with the amount of ingredients equal to 100%.

20. The use according to claim 9, wherein the specified aqueous hydrogen peroxide solution, designed for mixing with an aqueous solution of copper with the aim of obtaining this composition contains a stabilizer of hydrogen peroxide selected from phosphonates, perborates, in the amount of from 0.002 wt.% to 0.07 wt.%.

21. The use of claim 10, wherein the solution of copper added to an aqueous solution of hydrogen peroxide in a ratio of, for example, 1/25.

22. The use according to claim 1 for endoscope reprocessing.

23. The use according to claim 1, in which carry out the preliminary step of cleaning and/or disinfection for partial physical and/or enzymatic removal of particles of a HUNDRED or a prion.



 

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10 ex

FIELD: chemistry.

SUBSTANCE: invention relates to disinfection of freight compartments of vehicles and containers after transporting animals, materials and animal products, as well as other veterinary inspection items. The method of disinfecting vehicles and containers after transporting livestock cargo involves treatment a disinfectant containing the following components in wt %: propylene glycol 0.9-7.5; sodium nitrite - 0.2710-3-16.510-3; sodium benzoate - 1.3510-3-82.510-3; products of reacting glycerine with formic acid - 0.1810-3-11.010-3; a solution of oxidants synthesised from 10.0-20.0% sodium chloride solution subjected to direct current with intensity which ensures pH 7-8, active chlorine concentration 0.7-0.9% and redox potential +100050 mV - the balance. Treatment is carried out once with consumption of the disinfectant equal to 0.26-0.35 l/m2 with exposure of 55-65 minutes.

EFFECT: invention cuts the duration of the disinfecting process and consumption of the disinfectant while maintaining quality of disinfection, and also reduces the corrosive effect of the disinfectant.

4 tbl, 3 ex

Detergent sanitiser // 2448735

FIELD: chemistry.

SUBSTANCE: invention relates to detergents and disinfectants and can be used in mechanical or manual methods of washing and disinfecting equipment in medicine, agriculture, at food companies, public services facilities and on transport. The agent contains the following ingredients in a defined ratio of components: alkyldimethylbenzyl ammonium chloride, didecyldimethyl ammonium chloride, glutaric aldehyde, benzyl alcohol hemiformal, mixture of nonionic surfactants, complexing agents, isopropyl alcohol, turpentine and water.

EFFECT: invention ensures high antimicrobial activity and high detergent power.

4 cl, 5 tbl

Disinfectant // 2440146

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to veterinary, in particular to preparations for disinfection of objects of veterinary supervision against disease-causing microbes. Disinfectant includes glutaraldehide, glyoxal, alkylmethylbenzylammonium chloride and water, alkyldimethylethyl-benzylammonium chloride and anionic surface active substance, with the following component ratio, (wt %): glutaraldehide 3.0-4.0; glyoxal 2.5-2.8; alkylmethylbenzylammonium chloride 3.0-4.0; alkyldimethylethylbenzylammonium chloride 4.0-5.0; anionic surface active substance 8.0-9.0; water to 1 l. With application of 2% concentration disinfectant, consumption 400-500 ml/m2 and 60-120 minute exposition complete disinfection of objects against pathogenic organisms is achieved, the same effect being obtained with 3-% concentration of preparation and impact during 30-60 minutes.

EFFECT: invention ensures increase of disinfecting effect.

2 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention refers to public health, veterinary science, food processing, pharmaceutical and biotechnological productions. Disinfection objects are processed by the system of disinfectants consisting of at least two preparations, wherein at least one of the preparations is specified in a group of oxidants, namely oxygen-chlorine substances, and at least one of the preparations is specified in a group of non-oxidants, including, QACs - quaternary ammonium compounds, tertiary amines, aldehydes, guanidines. The system of disinfectants is packed within a package so that each preparation is placed separately, and each following preparation is used only after the previous preparation has been consumed completely.

EFFECT: invention provides the controlled rotation of disinfectants that prevents the developing acquired microorganism resistance.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly to stabilised aqueous antimicrobial compositions. The antimicrobial composition contains 2-25 wt % of 2,2-dibrom-3-nitrilopropionamide, 5-30 wt % of an aliphatic compound containing 2 to 6 hydroxyl groups, 20-70 wt % of ethylene glycol, 2-30 wt % of water.

EFFECT: invention provides stability and low viscosity of the composition.

10 cl, 5 ex

Disinfectant // 2481126

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

Disinfectant // 2481126

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical microbiology and medicine, namely to disinfection, and may be used for preparing disinfectants for disinfection of the surfaces contaminated by microorganisms, medical, sanitary and microbiological equipment. The disinfectant contains hydrogen peroxide, a water suspension of silver nanoparticles and non-ionic detergent Triton X-100 in certain amounts.

EFFECT: invention provides improved microbicidal activity on vegetative and spore forms of microorganisms at the low concentrations of its ingredients.

4 dwg, 3 ex

FIELD: chemistry.

SUBSTANCE: group of inventions relates to disinfection and sterilisation. The acidic liquid composition used is a liquid composition which contains (a) an acidic oxidant, (b) nitric acid or salt thereof and (c) at least one carboxylic acid selected from a group consisting of monocarboxylic acids, dicarboxylic acids and tricarboxylic acids, or salt thereof. In the disinfection and sterilisation method, the acidic liquid composition contains an acidic oxidant having an excellent corrosion inhibiting property (property of preventing rust, property of inhibiting formation of an oxide film) for aluminium-based metals even in acidic conditions, without affecting the appearance or function of such metals.

EFFECT: efficiently used to disinfect or sterilise an object having a part made from aluminium-based metals.

12 cl, 20 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to disinfectants. An antiseptic disinfectant contains the film-forming preparation iodopyrone containing 6-8% of active iodine and water, contains ethanol in the following proportions, wt %: iodopyrone - 1.0-1.3 (per active iodine basis), ethanol - 20, water - the rest. The antiseptic disinfectant represents a ready-to-use preparation presented in the form of a solution or a spray.

EFFECT: invention provides the qualitative and quantitative stability of the active substance in the easily water-washable disinfectant which does not stain and has a non-irritant, prolonged effect If kept in an unopened container, it has a shelf-life of 2 years from the date of manufacture.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to bactericidal medication and can be applied for disinfection of livestock premises, placed in them technological equipment, implements for animal care, vehicles for transportation of animals, places where animals and other objects of veterinary supervision are concentrated. Medication includes alkyldimethylbenzylammonium chloride (ADMBAC), glutaric aldehyde, water and sodium hydroxide, taken in specified ratio. In case of specified ratio synergetic effect is observed and maximal bactericidal activity of medication, assessed by value of minimal bactericidal concentration (MBC), at which death of test-culture is observed, is reached.

EFFECT: invention ensures increase of bactericidal activity and reduction of medication toxicity with minimal content of active substances.

1 tbl, 15 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to sanitation and can be applied in food, medical, veterinary, processing industry. Invention can be applied for obtaining preparations for disinfection of surfaces in premises, sanitary-technical equipment, items patient care, claimed disinfection preparation can also be applied for disinfection and pre-sterilisation cleaning of products of medical purpose, for disinfection and processing hands of medical personnel. Disinfection preparation includes quaternary ammonium compound, boric acid and represents water solution of quaternary ammonium compound, as such it contains diethyldichloropropenylammonium chloride or diethyldiallylammonium chloride, with the following ratio of initial components, wt %: said quaternary ammonium compound - 1.2 wt %, boric acid - 2.3 wt %, water - the remaining part.

EFFECT: invention ensures increase of bactericidal and fungicidal activity with reduction of concentration of working solutions of preparation, extension of action spectrum, including action on mycobacteria.

4 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, particularly to ophthalmology, namely: to antibacterial lenses containing metals, as well as to methods for producing them. The method for producing an antibacterial lens containing a metal salt involves the stages: (a) preparation of a hard lens by a salt precursor, as well as (b) preparation of the lens produced at the stage (a) by a disperse additive specified in a group consisting of polyvinylpyrrolidone, polyvinyl alcohol, glycerol and polyethylene oxide, and a metal-containing agent specified in a group consisting of silver tetrafluoroborate, silver sulphate, zinc acetate, zinc sulphate, copper acetate, copper sulphate, silver nitrate, manganese sulphide, zinc oxide, zinc sulphide, copper sulphide, copper phosphate, silver nitrate, silver sulphate, silver iodate, silver carbonate, silver phosphate, silver sulphide, silver chloride, silver chloride, silver bromide, silver iodide and silver oxide. The other method for producing involves the stages (a) of preparation of a hard lens by a metal-containing agent, and a disperse agent, (b) preparation of the lens prepared at the stage (a) by a salt precursor. The antibacterial lens containing the metal salt is produced by said methods.

EFFECT: group of inventions provides producing the lenses with a decreased degree of opacity.

16 cl, 1 tbl

FIELD: medicine, virology, pharmacy.

SUBSTANCE: invention relates to using derivatives of dithiocarbamate of the formula: R1R2NCS2H and oxidized forms of these compounds, in particular, their dimmers and their pharmaceutically compatible salts for preparing an agent used in treatment or prophylaxis of infection caused by RNA-containing viruses that damage respiratory tract and inducing disease. Also, invention relates to a disinfecting agent containing dithiocarbamate compound and a method for disinfection of surfaces, media and cell cultures.

EFFECT: valuable medicinal properties of compounds.

19 cl, 14 dwg, 14 ex

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