Method for preparing biocompatible nanostructure conducting composite

FIELD: medicine.

SUBSTANCE: invention refers to a method for preparing a biocompatible nanostructured conducting composite. The method involves preparing an ultra-disperse suspension of carboxymethyl cellulose and carbon nanotubes with the mechanical system of carbon nanotube structuring wherein nanostructuring is enabled by exposing the suspension to laser light in a continuous mode at generation wave lengths 0.81÷0.97 mcm and light intensity 0.5÷5 Wt/cm2.

EFFECT: invention provides preparing the high-conductivity bio-composite.

1 tbl, 1 ex

 

The invention relates to the field of biomedical engineering, in particular to methods for creating a conductive biocompatible materials used in the diagnosis, treatment, transmission of electrical signals, information, and energy. In medical practice, they can be used in cordial surgery, biosensors, against epilepsy, in the management of muscle tissue during electrical stimulation of the growth of biological tissues and restore functionalization of the nerves to transmit electrical signals in the process of stimulation of the organs and in other cases.

A method of obtaining biocompatible nanostructured composite electrically conductive material based on the polymer matrix, which can be added various nanoparticles, including carbon nanotubes (CNTS), carbon nanotubes, metal oxides, and others [1]. As the matrix polymer used materials from various groups, including: acrylates, acrylic acid, polyacrylic esters, polyacrylamides, polyacrylonitrile, chlorinated polymers, fluorinated polymers, polymers of styrene, synthetic rubber polymers, vinyl chloride-acrylate polymers, copolymers, etc. To achieve the biocompatibility of the material in its matrix injected substances with biological molecules from one or more of the RUPE, for example: biological electrolytes, nucleic acids, polyaminoamide, albumin, chitosan, carrageenan, carboxymethyl cellulose and other Filler (additive) selected from different groups, for example: biomolecules of one or more species, electrically conductive materials, carbon nanotubes, nanotubes of metal oxides, such as nanotubes, titanium dioxide, etc.

The disadvantage of this method of obtaining nanostructured conductive material is its difficulty making and low conductivity of the final product.

Known method of preparing fiber biocompatible nanostructured composite electrically conductive material in the matrix composition which is used as a material of the one or more groups, for example: biological electrolytes, nucleic acids, polyaminoamide, proteins, enzymes, polysaccharides, lipids and other [2]. Biological electrolytes may consist of one or several groups, including chitosan, spermidine, albumin, carrageenan, carboxymethyl cellulose, etc. as a filler, choose a variety of materials, including: carbon nanotubes and nanotubes of metal oxides. However, CNTS can be either single-walled (swcn)and multiwalled CNTS (Munt), and their concentration in the total mass of the composite is greater than 20%. Bisovsky nanostructure is consistent with a conductive material in the solid state could be obtained by dobavleniya in suspension special tools coagulators and pulling and twisting the fibers. With this method of making electrically conductive biocompatible material in the form of fibers of carbon nanotubes primarily oriented along its length, and thereby achieve high conductivity fibers.

The disadvantage of this method of obtaining nanostructured electroconductive material is the difficulty and the one-dimensional form (fiber) conductive end product.

The closest technical solution is a method of obtaining three-dimensional biocompatible nanomaterial containing carbon nanotubes, characterized in that conduct laser irradiation of the aqueous solution until the evaporation of the liquid component of the solution [3]. The disadvantage of this method is not strictly controlled exposure mode, because to obtain the final nanomaterial basically requires the evaporation of the liquid component of the solution. However, to obtain nanomaterials with a maximum electrical conductivity requires selection of the optimal mode of laser radiation.

The task of the invention is to develop a method of producing a composite biocompatible nanomaterial with high electrical conductivity due to the nanostructuring of carbon nanotubes in suspension by acting on the suspension by laser radiation.

Specified t is khnicheskie result reach those in a known method of obtaining biocompatible nanostructured composite conductive nanomaterial, comprising preparing ultradimensional suspension of biocompatible material and carbon nanotubes, in which the nanostructuring of carbon nanotubes in suspension hold action on the suspension by laser radiation in a continuous mode at wavelengths generation 0,81÷0,97 μm and the irradiation intensity of 0.5÷5 W/cm2. In the specified method of obtaining biocompatible nanostructured composite electrically conductive material as a biocompatible material used carboxymethylcellulose.

At wavelengths 0,81 μm and 0.97 μm has a high absorption of the laser radiation of the composite material, and the field intensity I≈0,5÷5 W/cm2optimal structuring of carbon nanotubes. It should be noted that when I>5 W/cm2it overheating and burning of the material, as when I<0.5 W/cm2the electric field created by the laser beam in the material is weak, and accordingly, the nanostructuring of carbon nanotubes in the material is not enough.

In the claimed invention were prepared suspension with the main components in the following proportions (in % by weight):

Carboxymethylcellulose (CMC)3-5
Munt0,1-0,5
Waterthe rest.

The proposed method allows the preparation to obtain nanostructured composite conductive material with any topological form (3-D, 2-D, 1-D) and consistency.

Traditional metal wires have drawbacks: low biocompatibility, lack of mechanical and conductive properties. For example, tensile strength and electrical conductivity, normalized to the density of the material, the copper nanowires by several orders of magnitude less than that of carbon nanotubes (CNTS). CNTS can withstand the high current density (≥108A/cm2), which is 4-5 orders of magnitude greater than that of copper nanowires [4]. Thus, nanowires based on CNTS will be in demand as in biomedical applications, and in micro - and nanoelectromechanical systems.

High conductivity composite biocompatible nanomaterial additives Munt associated with many factors, including high efficiency of coagulation of the suspension CMC+Munt under the influence of laser radiation; structuring of carbon nanotubes advantages of the NGOs in the same direction - in the direction of the electric field of the laser beam. The strong electric field of the laser radiation in suspension orients carbon nanotubes in the form of parallel wires and, thereby, increases the conductivity of the nanomaterial.

An example of implementing the method of producing nanostructured composite electrically conductive material. At room temperature in distilled water dissolve the powder CMC. The suspension is stirred with a mechanical stirrer within 0.7 to 0.9 hour. Then, the resulting suspension was dispersed in an ultrasonic bath for 0.8 to 1.0 hours. In the next step, add the powder Munt and obtained a suspension of CMC+Munt mixed and dispersed similarly CMC. Received ultradimensional suspension is poured into the desired shape and through its open surface conducting laser irradiation. The laser light source may be a laser length λ of the wave generation in the region (0,81-0,97) μm, in particular infrared diode laser λ=0,97 μm with optical output radiation. The intensity of radiation incident upon the surface of the suspension is adjusted in the range of 0.5-5 W/cm2.

Under the influence of the laser radiation can cause coagulation, condensation) suspension, is the structuring of the CNTS in the direction of the electric the field of laser beam and simultaneously suspension loses moisture by evaporation. In the dried state, the mass of nanomaterial approximately 10 times less than its weight in suspension.

In the preparation of nanostructured composite biocompatible nanomaterial controlled settings: exposure mode (continuous, pulsed), irradiation time, irradiation intensity, the temperature of the suspension, and the percentage by weight of the components. This control allows to obtain the desired material with electrical conductivity in a wide range 100-5000 Cm/m

Table 1 shows typical values of σ for composite biocompatible nanomaterials having different compositions, where 4 wt.% CMC (suspension) - 4 wt.% carboxymethylcellulose (aqueous suspension); 4 wt.% CMC (dried) - carboxymethylcellulose in dried form; 4 wt.% CMC + 0.5 wt.% carbon black K-354 - a mixture of carboxymethyl cellulose and carbon black K-354 in dried form; 4 wt.% CMC + 0.5 wt.% Munt (suspension) - carboxymethylcellulose and Munt (aqueous suspension); 4 wt.% CMC + 5 wt.% Munt (dried) - carboxymethylcellulose and Munt in the dried form. In the latter case, the concentration Munt was estimated taking into account the loss of moisture suspension 4 wt.% CMC + 0.5 wt.% Munt (suspension) when coagulation and drying. It should be noted that the end product of 4 wt.% CMC + 5 wt.% carbon black K-354 (dried) prepared the purposes of mapping to the core product 4 wt.% CMC + 5 wt.% Munt (dried). You can see a huge advantage in conductivity (more than 4 orders of magnitude) nanostructured composite nanomaterial-based Munt relative to the composite material based on carbon black K-354. The method of preparation and the percentage of trains for both cases are identical.

Table 1
Conductivity of the composite of biocompatible materials of various composition.
Material/ beats. wire.4 wt.% CMC (suspension)4 wt.% CMC (dried)4 wt.% CMC + 5 wt.% carbon black K-354 (dried)4 wt.% CMC + 0.5 wt.% Munt (suspension)4 wt.% CMC + 5 wt.% Munt (dried)
and, Cm/m10,10,1105000

Thus, in the proposed invention in the selection of the optimal mode of nanostructuring by laser irradiation received biocompatible electrically conductive nanomaterial and achieved higher conductivity p and low concentrations of multiwall carbon (~5%) of the nanotubes relative to the conductivity of known biocompatible nanomaterials [1, 2, 5, 6].

Sources of information

1. U.S. patent 2010/0068461.

2. U.S. patent 2010/0023101.

3. Ageeva S.A., Bobrinetskiy I. I., Nevolin C. K., Podgaetskii V.M., O. Ponomarev, the problem with VV, Simonin M.M., selishev SV / Method of nanostructuring of bulk biocompatible materials // Patent RU 2347740. (prototype).

4. Ngo Q., A. M. Cassell, A.J. Austin, and et al. / Characteristics of aligned carbon nanofibers for Interconnect Via applications. // IEEE. Elec. Dev. Lett., 2006, v.27(4), pp.221-224.

5. Ostiguy, C., Lapointe G, Trottier M, Menard L., Cloutier Y., Boutin M, Antoun, M., Normand Ch. / Health effects ofnanoparticles. Studies and research projects. IRSST. 2006. p.52.

6. Allsopp. M., Walters, A., Santmo D. / Nanotechnologies and nanomaterials in electrical and electronic goods: A review of uses and health concerns // 2007. Greenpeace research laboratories. December. 22 p.

A method of obtaining a biocompatible nanostructured composite electrically conductive material, comprising preparing ultradimensional suspension of carboxymethyl cellulose and carbon nanotubes, with a mechanical system structure of carbon nanotubes, characterized in that the nanostructuring of carbon nanotubes in suspension hold action on the suspension by laser radiation in a continuous mode at wavelengths generation 0,81 to 0.97 μm and the irradiation intensity of 0.5 to 5 W/cm2.



 

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