Corn plaster

FIELD: medicine.

SUBSTANCE: invention refers to medical and chemical-pharmaceutical industry and is applicable in healthcare facilities and domiciliary for external application as a remedy in skin diseases: corns, plantar callosities, callules. A corn plaster contains salicylic acid, precipitated sulphur, anhydrous lanolin, pine rosin, lump rubber, dimethylsulphoxide, pine resion, petrolatum and agidol with salicylic acid used as micronised particles sized max. 30 mcm, and the ingredients taken in certain proportions. The experimental clinical findings have shown that the leukocytic mass applied on corns has an effect on adjoining skin areas causing no allergy, irritation or redness if the plaster is applied on healthy skin.

EFFECT: corn plaster improves keratolytic, antiseptic and antimycotic properties ensured by qualitative and quantitative composition of the ingredients.

 

The invention relates to medical and pharmaceutical industry and can be used in medical institutions and in the home for outdoor use as therapeutic tools for diseases of the skin: blisters, corns, callus.

One of the oldest medicinal forms used to prevent any skin from harmful external influences, to conceal the defects of the skin, to fix on the skin surface dressings for the treatment of diseases of musculoskeletal system, treatment of corns, etc. are the patches.

Such therapeutic effects have known dosage forms: mustard plasters: pepper, bactericidal, corn. For the manufacture of such dosage forms use different structures.

Known adhesive tapes contain as a basis layer of adhesive material, which is a blend of rubber with the resin, fat-like and some other substances and included in lammasu medicinal substances that have beneficial effects on the skin of the patient (Ant IA Technology of drugs. - M.: Medicine, 1988).

For the treatment and removal of the formed skin dry corns, callus, corns in medical practice to use liquid corn, PROTIVOPOZHARNOY ointment PL is stir corn. Existing products are cumbersome and inefficient.

Known plasters "Mozolin" (patent RF №2148978, 20.05.2000,), contain salicylic acid, sulfur, precipitated, pine rosin and the other constituent parts of the softener. As a softener patch contains anhydrous lanolin, paraffin and vaseline oil, and salicylic acid found in high concentrations in the following ratios, wt.%:

vaseline oil4,8-10
salicylic acid21-47
sulfur precipitated5-12,2
lanolin anhydrous9,1-16,1
pine rosin5-15
paraffin17-25

Plasters contains adhesive tape coated with corn mass. On sticky tape imposed protective strip of cloth thermally atraumatic with a hole in the center, filled with a homogeneous adhesive corn mass, covered with the sticky side of the protective layer of the film of polyethylene terephthalate or of the boom the guy siliconized.

The closest analogue (prototype) is a self-adhesive corn plaster, contain salicylic acid, sulfur, precipitated, natural rubber, anhydrous lanolin, pine rosin, and other components. The composition is applied on strips of cloth and covered with a protective layer of film (Medmaravis - Drugs. - M.: Medicine, Vol.2, 1986, s - prototype).

However, these corn adhesive tapes have insufficient keratolytic and antibacterial action due to the fact that is insoluble in the mass of particles of salicylic acid have a size of 100 μm or more. The particle size of 100 μm or more, on the one hand, provides insufficient active surface of the substance, and on the other hand, the process ensures the application of a sufficiently thick layer of leukomas. Therapeutic components of the patch have weak penetration into skin layers, which reduces the effectiveness of its actions.

The disadvantage of plaster is that imposed on corn laconassa also affects the healthy surrounding skin areas that are not desirable, possible allergic reactions, irritation and redness of the skin after contact patch on the healthy skin. In addition, the known adhesive tape unstable during storage and its manufacture requires high the quality of raw materials.

The purpose of this solution is expanding Arsenal of therapeutic tools for diseases of the skin: blisters, corns, callus.

The technical result of the claimed invention is an improvement keratolytic, antiseptic properties of the corn patch, eliminate redness and irritation, and reduced consumption lakomski patch, that reduce the cost of the product.

The problem is solved as follows:

Plasters contains salicylic acid, sulfur, precipitated, anhydrous lanolin, pine rosin, pine resin, vaseline oil, natural rubber, Agidol and dimethylsulfoxide, while salicylic acid is used in the form of micronized particles of a size not more than 30 μm and components take the next time quantitative content, wt.%:

salicylic acid15,0 35,0
sulfur precipitatedof 8.5 to 12.0
the sulfoxide0,3-0,6
lanolin anhydrous10,0-16,0
pine rosin15,0-17,0
pitch pine4,0-6,0
vaseline oil5,0-10,0
Agidol0,5
natural rubberrest

Micronized salicylic acid with a particle size of not more than 30 μm provides a higher keratolytic action by increasing the active surface of particles of a specified substance.

Sulfur precipitated possesses anti-inflammatory, antibacterial and keratolytic action. When applied externally, sulfur interacts with organic matter, forming sulfides and pentationovuyu acid, which have antibacterial and keratolytic action.

Dimethyl sulfoxide quickly penetrate through biological membranes, increasing the diffusion, including through the skin and mucous membranes, increases their permeability to other medicines. Dimethyl sulfoxide has a local anesthetic, anti-inflammatory, antimicrobial (antiseptic), fibrinolytic action.

Agidol 2 - (2,2-methylene-bis(4-methyl-6-tertbutylphenol) produced according to TU 2492-433-05742686-98, is a colorless treatment and neobespechenii antioxidant. Used for stabilization of rubbers, rubbers,latexes. Non-toxic, meletus, stable during storage. Easily soluble in ethyl alcohol, acetone, ethyl acetate, carbon tetrachloride and benzene, trudnorastvorim in gasoline, practically insoluble in water.

Lanolin protects the adhesive from hardening, absorbs moisture on the patient's skin, resulting in adhesive properties of the patch stored for a long time. Liquid paraffin is used in the patch for suspending medicinal substances and as softener of rubber, protecting it from hardening. Rosin increases the adhesiveness of the patch.

Cooking corn mass is carried out in two mixers. In the first mixer to prepare the adhesive part of the corn mass. In a mixer, pour a solution of rosin in the gasoline, pour the gasoline, then download natural rubber and Agidol. Mix for at least 5 hours to dissolve the rubber in gasoline and obtain rubber glue. Then load the solution of rosin in three steps, after each batch is stirred for 30 minutes, the resin of the pine stirred for 30 minutes, gasoline stirred for 30 minutes, dimexide stirred for 30 minutes.

Rubber adhesive that provides good adhesion to the adhesive tape, has the following composition, g:

natural rubber
pine rosinof 17.0
pitch pine5,0
Agidol0,5
the sulfoxide0,5

In the second mixer to prepare biologically active therapeutic part of the corn mass of the following composition, g:

sulfur precipitated8,5
salicylic acid with a particle size of not more than 30 microns32,3
lanolin anhydrous10,0
vaseline oil5,0

Salicylic acid before using pulverized in a ball mill until the particle size is not more than 30 μm, which is not less than 0.5 hour. Next salicylic acid are placed in a mixer, spend it disaggregation 30 minutes, download the precipitated sulfur, stirred for 30 minutes and injected the mixture is preheated lanolin and vaseline oil. The components are stirred for 0.5 hour.

Adhesion and therapeutic part of the corn mass is mixed in the same mixer for 30 minutes

NAS is safety on the weight of the fabric and drying to produce Unil. Released from corn mass pairs nefras passed through the adsorber, where they are absorbed, and then desorbers.

The rolls are sent to the cutting and forming. The finished plaster corn is a strip of fabric coated with a uniform layer of the corn mass, covered with a protective coating of siliconized paper or film.

Load on weight is not less than 200 g/m2this figure is lower than that of counterparts, which reduces the consumption of corn mass, that reduce the cost of the finished product.

In addition, the claimed adhesive is a solid and stable weight during storage at room temperature and razmyagchayuschiesya when the temperature of the human body.

Experimental clinical trials have shown that imposed on corn laconassa effect on the surrounding healthy skin, does not cause allergic reactions, irritation and redness of the skin after contact patch on the healthy skin.

The inventive plaster corn improves keratolytic, antiseptic and antifungal properties due to the qualitative and quantitative composition of its components.

Plasters, including salicylic acid, sulfur, precipitated, anhydrous lanolin, pine rosin and the couch is natural, characterized in that it further comprises dimethyl sulfoxide, pitch pine, vaseline oil and Agidol, while salicylic acid is used in the form of micronized particles of the crystals is not more than 30 μm and components take the next time quantitative ratio, wt.%:

salicylic acid15,0-35,0
sulfur precipitatedof 8.5 to 12.0
lanolin anhydrous10,0-16,0
pine rosin15,0-17,0
the sulfoxide0,3-0,6
pitch pine4,0-6,0
vaseline oil5,0-10,0
Agidol0,5
natural rubberrest



 

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