Biocidal compositions of hydrogen peroxide with improved activity

FIELD: chemistry.

SUBSTANCE: invention relates to a biocidal composition containing hydrogen peroxide in concentration of 0.05-50% (wt/wt) and a compound of formula 1: (OH)(2-m)(X)(O)P-[(O)p-(R')q-(CH(Y)-CH2-O)n-R]m, where X is H or OH; each Y is independently H or CH3; m equals 1 and/or 2; each p and q is independently equal to 0 or 1, provided that if p equals 0, q equals 1; each n is independently equal to 2-10; each R' is independently an alkylene radical containing 1-18 carbon atoms; each R is independently H or an alkyl radical containing 1-18 carbon atoms; and R'+R≤20; in concentration of 0.01-60% (wt/wt), as a biocidal composition. The invention also relates to use of the disclosed composition as a biocidal composition, as well as for purposes where there is need for disinfection and/or sanitation activity.

EFFECT: composition has excellent biocidal activity.

25 cl, 9 tbl, 10 ex

 

Description

This invention relates to the field of disinfection and cleaning, and more particularly to compositions with improved biocidal activity on the basis of hydrogen peroxide, which also have improved stability.

Many classes of chemical compounds have varying degrees biocidal or antimicrobial activity. Biocidal compositions are required, among other things, to clean and disinfect the surface of foods, such as fruits and vegetables, and to clean and disinfect hard surfaces in the healthcare and food industries, as well as in the household.

The last few years, efforts have been concentrated on the development of chemical compounds that would be highly effective against microorganisms, while in diluted form, was non-lethal to humans and other animals and not harm the environment.

Known disinfectant and biocide means of hydrogen peroxide shall be considered as having exceptional potential, because the products of its decomposition, water, and oxygen are non-toxic and do not harm the environment. It also has a wide range of biocidal activity. A wide range of activity is important, for example, in situations where pathogens are present, but not identified. Disinfectants on cos the ve hydrogen peroxide are used in many different areas, including hospitals, clinics, laboratories, dental clinics, the household and the care of chronic patients. They can also be used when handling and preparing food and drinks, animal husbandry, the hotel industry and for General sanitation.

To ensure rapid, effective action, in biocidal solutions of hydrogen peroxide is necessary to apply a relatively high concentration of hydrogen peroxide. However, at higher concentrations, the solutions can fall under the regulations for handling hazardous products and require special precautions when handling and application. For example, in concentrations of more than about 8% wt./wt. aqueous hydrogen peroxide is corrosive and is also a strong oxidizing agent. Solutions containing less than about 8% wt./wt. hydrogen peroxide is preferred because of the improved safety performance.

Compositions based on hydrogen peroxide as the sole biocide compounds, and containing up to 7% wt. hydrogen peroxide by weight of the entire composition, are not fully effective for the disinfection of contaminated surfaces, such as surfaces that must be cleaned and disinfected. Of course, the presence of organic and/or inorganic contaminants reduces bactericidin the th activity of many antimicrobial agents, such as the agents based on peroxide, thereby reducing the bactericidal activity and disinfectant effect compositions containing them.

At low concentrations (for example, 3% wt./wt.) hydrogen peroxide does not irritate the skin, but has a low germicidal activity. For example, a solution containing 3% wt./wt. hydrogen peroxide, it takes 20 minutes to achieve a 6 log reduction of Staphylococcus aureus that is too long for some applications. The increase in the concentration of hydrogen peroxide increases the rate of disinfection. For example, 25% wt./wt. aqueous solution of hydrogen peroxide is required only 20 seconds to achieve more than log 6 reduction of Staphylococcus aureus. However, in such concentrations, the solution is corrosive and requires special procedures in the application.

Another disadvantage of the use of the compositions of hydrogen peroxide is that without the use of the stabilizer or combination of stabilizers aqueous composition of hydrogen peroxide can usually decompose within a relatively short period of time.

In this area of technology, it was proposed several options for obtaining the compositions of hydrogen peroxide with improved biocidal activity.

In WO 97/31093 described disinfecting composition comprising a peroxy bleach, such as hydrogen peroxide, AMFOT the RNA surfactant, for example betaine, glutaric aldehyde, and an antimicrobial essential oil.

In WO 01/65939 described bactericidal properties of the combination of hydrogen peroxide, benzalkonium salt and complexing compounds with inorganic phosphate.

In the US 6479454 and US 6444230 described improved antimicrobial activity of the combination of peroxide compounds with amine oxide.

In WO 03/067989 described the use of certain anionic surfactants based on sulfonic acid in combination with hydrogen peroxide.

The object of the present invention are compositions which have excellent biocidal activity and are subject to possible small concentrations of hydrogen peroxide and/or as little as possible other biocidal additives. It is also an object of this invention is a composition which can be applied without the use precautions when handling or applying security measures and which does not require rinsing or requires only rare rinsed off after application. The present invention unexpectedly found that compositions containing a combination of hydrogen peroxide with certain phosphate or phosphonate compounds have superior biocidal activity. The compositions also exhibit a significant increase in stability compared with the solutions of the peroxide is hydrogen, contains no discussion of the connection.

WO 2004/067194 relates to a stabilized aqueous compositions that contain hydrogen peroxide, surfactant based on ethoxylated aliphatic phosphono formula (I), (HO)(3-m)OP(R-(CH2-CH2-O)n-R1)mor (HO)(3-m)OP(O-(CH2-CH2-O)n-R1)mor (HO)(3-m)OP(O-R1-(CH2-CH2-O)n-H)mand at least one additional detergent surfactant. It was found that the compound of formula (I) gives the composition a very good aesthetic properties (clear gel) and helps to stabilize the formula even at high temperatures (about 40°C for up to 6 months). In addition, the composition is resistant to light, in particular UV light.

In WO 97/47718 described thickening agent for aqueous solutions of hydrogen peroxide, providing a reliable and constant viscosity characteristics and makes it easy to enter odorants without causing turbidity. Thickening agent contains from 10 to 90% alkanolamide fatty acids, from 5 to 20% sulfate Olkiluoto ether and optionally up to 5% phosphate Olkiluoto ether and up to 60% alkylpolyglycoside ether.

However, in these two documents is not mentioned improved biocidal activity of compositions containing surface-active the substances based on ethoxylated aliphatic phosphono/phosphate Olkiluoto ether. In addition, compounds with structure of formula 2 is not described in these two documents.

Thus, in the first aspect of this invention relates to the use of biocidal compositions based compositions containing hydrogen peroxide at a concentration of 0.05-50% (wt./wt.) and the connection with the structure of formula 1:

(OH)(2-m)(X)(O)P-[(O)p-(R')q-(CH(Y)-CH2-O)n-R]mor their salts,

where X is H or OH; each Y independently is H or CH3; m is 1 and/or 2; each p and q is independently 0 or 1 provided that when p is 0, q is 1; each n is independently equal to 2 to 10; each R' independently is alkilinity radical containing 1-18 carbon atoms; each R independently is H or alkyl radical containing 1-18 carbon atoms; and R'+R ≤ 20;

at a concentration of 0.01-60% (wt./wt.).

The composition has unexpectedly excellent biocanol activity, even when diluted to a composition containing 0.05 to 8% hydrogen peroxide and 0.01-10% of the compound structure of formula 1. It also shows good stability over time. The combination of hydrogen peroxide and compounds of formula 1 gives a more powerful biocidal composition compared to compositions that can be applied with the use of these two compounds separately.

If not indicated otherwise, the percentages given in the description, are Mac is UNIX percent relative to the weight of the entire composition.

Biocidal activity specified in the description, includes biocidal activity against all types of microorganisms, bacteria, yeast and fungi and viruses.

Formula 1 refers to the single homogeneous connections and heterogeneous mixtures of compounds. For example, a heterogeneous mixture may contain compounds in which the value of n and/or length alkalinous and/or alkyl radical varies between different values, where the values for n and the length of the chains R' and R such as defined herein, are average values. In addition, the heterogeneous mixture may contain a mixture of mono - and diesters of formula 1. Mono - and diesters of formula 1 are compounds in which m is 1 or 2, respectively. Preferably, these mixtures of monoether was the predominant form, ie accounted for at least 50% of such a mixture, preferably at least 60%, more preferably at least 70%, even more preferably at least 80%, most preferably at least 90%.

In the preferred structure of formula 1, X is OH, Y is H, n is 2-8, preferably 2-6, more preferably 4-6, most preferably 4, and/or R'+R contains 4-18 carbon atoms, preferably 4-16 carbon atoms, more preferably 6 to 14 carbon atoms, even more preferably 8 to 12 atoms of plastics technology : turning & the Yes, even more preferably 8-10 carbon atoms. Also preferably, R and R' are radicals with a straight chain. In another preferred structure, the value of p is 1 and q is 0.

A particularly preferred compound for use in accordance with this invention is another aspect of the present invention. This compound has the structure of formula 1, where m is 1, p is 1 and q is 0, i.e. the connection structure of formula 2: (OH)(X)(O)P-O-(CH(Y)-CH2-O)n-R, or its salt, where X is H or OH, Y is H or CH3, n is 4 to 8 and R is an alkyl radical containing 4-18 carbon atoms in a concentration of 0.01-60% (wt./wt.).

In the preferred structure of formula 2, X is OH, Y is H, n is 4-6, preferably n is 4 and R is an alkyl radical containing 4-16 carbon atoms, preferably 6 to 14 carbon atoms, more preferably 8 to 12 carbon atoms, most preferably 8-10 carbon atoms. Also preferably, R is an alkyl radical with a straight chain.

In a particularly preferred structure of formula 2, X is OH, Y is H, n is 4-6, preferably n is 4 and R is an alkyl radical with a straight chain containing 8 to 12 carbon atoms, preferably 8-10 carbon atoms.

Composition for use in accordance with this invention preferably can prod Atisa in the form of a concentrate, hydrogen peroxide in concentrations which may range from about 10-50%, and a connection structure of formula 1 in a concentration that can vary from about 5-60%. Specified concentrate can easily be diluted to the effective concentration used for the final goals.

Upon dilution with an effective concentration of hydrogen peroxide in the composition may range from 0.05 to 8% (wt./wt.), preferably, 0.1 to 5%, more preferably 0.2 to 3%, most preferably 0.3 to 2%. Depending on the intended application of the composition the concentration of hydrogen peroxide can be higher, for example, from 1 to 8% or lower, for example, from 0.05-1%. The concentration of compounds of structure of formula 1 may be from 0.01 to 10% (wt./wt.), preferably 0.05 to 5%, more preferably 0.1 to 2%.

The concentration of hydrogen peroxide and compounds of structure of formula 1 in the composition is preferably chosen so that the mass ratio between hydrogen peroxide and the compound structure formula 1 varies between 10 and 0.1, more preferably from 5 to 0.2, most preferably from 2 to 0.5.

In one embodiment of the present invention a composition in accordance with this invention is produced by dissolving the dry granular composition in water. In this embodiment, the hydrogen peroxide produced from paracaseinate, such as Perca is beat sodium, monohydrate, sodium perborate, tetrahydrate sodium perborate, decahydrate of sodium tetraborate, or mixtures thereof. This gives the possibility to use solid composition comprising forming a peroxide compound and a connection structure of formula 1 or 2.

Thanks to the efficiency of the combination of hydrogen peroxide and compounds of structure of formula 1, the composition can be applied in the form of a simple composition. For many applications it may be necessary to add to the composition an additional connection, influence (improve) its biocidal activity. Thus, in these embodiments, the composition consists essentially of hydrogen peroxide and compounds of structure of formula 1 as compounds with biocidal activity.

Biocidal activity of the composition for use in accordance with this invention preferably determined by testing controlled bactericidal suspension, the relevant European standards for chemical disinfectants and antiseptics EN 1276 EN 1276: Quantitative testing of suspension for the evaluation of bactericidal activity of chemical disinfectants and antiseptics used in food industry, light industry, household and medical institutions: the testing procedure and requirements). Effective biocidal composition is to notice, which provides at least log 3 reduction after 1 minute of contact with the test suspension of Staphylococcus aureus containing 108CFU per ml, preferably at least log 4 reduction, more preferably at least 5 log reduction, most preferably at least log 6 reduction.

Depending on the tested microorganism, it is possible to apply the test suspensions intended for use with fungi, yeasts or viruses. For fungi or yeast can be applied tests according to European standards EN 1275, EN 1650 or EN 13624. Viruses can be used test according to European standard EN 14476.

Finally, the test according to European standard EN 13704 suitable for evaluation sporicidal activity of chemical disinfectants used in food, light industry, household and medical institutions.

Biocidal peroxide composition for use in accordance with this invention preferably is an aqueous solution.

Examples of compounds of structure of formula 1 include:

Uniqema:
- Monafax 1214aliphatic C8-10, AA
- Monafax 831aliphatic
Basf:
- Maphos 60Aaliphatic C10 ethoxylate - monoether
- Maphos 58aliphatic
Akzo:
- Phospholan PE 169phosphate C13 isotridecyl ether
Zschimmer &Schwarz:

- Phosfetal 201aliphatic C12 (a mixture of mono - and diapir)
- Phosfetal 213aliphatic C18 (mixture of mono - and diapir)
Elementis:
- SERVOXYL VPBZ 5/100, C12-C16 5 EA based on coconut, mono - and W
- SERVOXYL VPDZ 3/100, C13, 3 EA, mono - and fluids (phosphate ester polietilenglikoli ether (3 EO) (C13))
- SERVOXYL VPDZ 6/100, C13, 6 EA, mono - and fluids (phosphate ester polietilenglikoli ether (6 EA) isotridecyl alcohol (C13))
- SERVOXYL VMDZ 6/100, C13, 6 EA, about 90% of monoether
- SERVOXYL VPTZ 3/100, C8, 3 ethylene oxide, mono - and fluids (phosphate ester polietilenglikoli ether (3 EO) 2-ethylhexanol)

In a preferred embodiment, the biocidal composition peroxide for use in accordance with this invention is a ready to use aqueous solution containing 0.1-5% hydrogen peroxide and 0.05-5% of the compound structure of formula 1. the pH of the solution is preferably 2-5.

Such compositions also harmless to the environment.

Particularly preferred compounds for use in accordance with this invention include compounds such as Phosfetal® 201, SERVOXYL VMDZ 6/100, SERVOXYL VPBZ 5/100 Maphos® 60A (BASF) and Monafax® 1214 (Uniqema). Especially Monafax® 1214 is vysokoposeschaemym product with very good biocidal properties in combination with hydrogen peroxide, which has received the eco-label from the Swedish society for nature conservation. This allows you to apply the solution in situations where the preferred products are harmless to the environment.

Various other compounds may be added to the compositions to improve their practical application.

For example, a pH regulating acid (organic or inorganic) or base or a suitable buffer may be added, if appropriate, to obtain compositions with the desired pH. Preferably the composition has a pH in key the pilot interval, more preferably pH 1 to 8, even more preferably pH 1.5 to 6 and most preferably a pH of 2-5.

The composition may also contain a stabilizer of hydrogen peroxide is preferably in the form of a cationic complexing compounds, preferably in concentrations of from 0.01 to 20% (wt./wt.). Cationic complexing agent may be selected from ethylenediaminetetraacetic acid (edtc), diethylenetriaminepentaacetic acid (TPC), N-(hydroxyethyl)ethylenediaminetriacetic acid (GATC), nitrilotriacetic acid (NTC), 2-hydroxyethylaminomethyl acid (GEEK) and their salts or from benzoic acid, aminobenzoic acid, citric acid, phosphoric acid, iminodiethanol acid and poliasparaginovaya acid. More preferably the cationic complexing compound is (colloidal) stannat and even more preferably it is chosen from acetanilide, disuccinate ethylenediaminetetra, for example, OctaQuest E30 or A65 (Octel), derivatives of phosphonic acid having from 1 to 5 phosphonic acid groups, for example, Dequest phosphonate (Solutia), 1-hydroxyethylidene-l,1-diphosphonic acid, aminotri(methylenephosphonic acid), diethylenetriaminepenta(methylenephosphonic acid), 2-hydroxyethylamine(methylenephosphonic acid) and ethylenediaminetetra(methylenephosphonic acid).

The composition can also in order to gain the corrosion inhibitor preferably in a concentration of from 0.01 to 20% wt./wt. Preferably the corrosion inhibitor selected from 1,2,3-benzotriazole, sodium molybdate, sodium nitrite, sodium bisulfate, metabisulfite sodium, chromates, borates, phosphates, polyphosphates, sodium benzoate, sodium gluconate and sodium silicate.

The composition may also contain compatible with hydrogen peroxide surfactant. Such surfactant may be anionic, cationic, nonionic and/or amphoteric surface-active substance. The concentration of surfactant may be 0.005 to 40% wt./wt.

Examples are compatible with hydrogen peroxide nonionic surfactants include amine oxides, ethoxylated fatty alcohols and/or alkyl(poly)glycosides.

Preferred compatible with hydrogen peroxide nonionic surfactants include amine oxides, such as oxides, C8-C20 of alkyldiphenylamine and/or oxides, C8-C20 of alkyldiphenylamine, such as oxide dimethylbenzylamine or oxide dimethylalanine. Preferred compatible with hydrogen peroxide amphoteric surfactants include betaines, such as C8-C20 alkyldiphenylamine, such as cocamidopropylbetaine, and/or C8-C20 alkylsulfonate.

In this invention it has been unexpectedly found that a composition comprising a combination of peroxide is odorata, compounds of structure of formula 1 and the amine oxide and/or betaine, has a very good biocidal activity, while having a very good cleaning and degreasing properties.

Also the composition may contain at least one C1-C8 alcohol, preferably in a concentration of from about 0.01 to about 10% wt./wt. The alcohol may be selected from benzyl alcohol, ethanol, n-butanol, 1-propanol, isopropanol and glycols, such as ethylene glycol, propylene glycol and butyleneglycol.

Other additives can be added to the biocide composition peroxide to obtain a composition with properties suitable for its application. Examples of such additives include emulsifiers, solvents, hydrotropes, glycerine, flavors, colors, preservatives, antifoaming agents and corrosion inhibitors.

The present invention presents the use of biocidal compositions of hydrogen peroxide for any purpose requiring disinfection and/or decontamination. The composition also can mainly be used for purposes where, in addition to the disinfecting activity, may need cleaning and/or bleaching and/or conservation activity. Application in accordance with this invention includes a contact substrate, which is considered contaminated by microorganisms, biocidal composition of hydrogen peroxide. Thanks efficiency the efficiency of the composition, the contact time is usually no more than 1-5 minutes. Applications include use as bactericidal and sterilizing rinsing and cleaning fluid, and also as a disinfectant, cleansing and sanitizing agent, such as disinfectant soap.

In particular, the biocidal composition peroxide can be applied in those areas where it is important to ensure disinfection and/or sanitization, preferably in combination with a cleaning and/or bleaching and/or conservation activity, with a maximum soft agent, for example, in the household, medicine, personal hygiene, oral hygiene, food, cleaning rooms, etc. in the areas where it is preferable not to wash or rarely wash solution after application, or where the solution may come in contact with food.

As biocidal composition of hydrogen peroxide is not irritating, odorless and contains no volatile gases, and does not damage the skin, it is also optimal for situations in which consumers do not wear protective clothing, in cases where the safety of workers is the top priority, or for personal use, such as disinfection of wounds or prevention of gingivitis.

This invention also relates to the use of biocidal compositions peroxide in specific devices, such as spray devices such as the p aerosol bottles, aerosol containers, devices for obtaining aerosol disinfection of rooms and for application in the form of mikania.

The preferred application of the biocidal compositions of hydrogen peroxide relates to the application as agent for the disinfection of skin, preferably for hand disinfection.

To improve the practical applicability and effectiveness as a disinfectant for skin conditioners for the skin can be added to the composition. Air conditioning for the skin can be selected from glycerides, sorbitol, castor oil (water soluble) silicones, allantoin, cationic polymers, lanolin and its derivatives, and cetyl alcohol.

The composition may also contain non-ionic surfactants to improve the ability to wetting and improve dry hands. Also agents for removing grease, oil and/or stains and degreasing agents, such as anionic, nonionic or amphoteric surfactants or alcohols, may be added in certain situations that require the removal of grease or stains.

The problem of existing products for disinfection of the skin, usually containing alcohols in high concentrations, iodine/iodophor, chlorhexidine gluconate (HCH), phenolic compounds, Quaternary ammonium compounds or combinations thereof, lies in the fact that they often disinfecting activity is being sacrificed to the softness of the skin and Vice versa. For example, although the increase in the concentration of the active ingredient leads to a greater level of disinfection, such high concentrations often cause increased skin irritation.

Composition means for disinfection of the skin (hands) mainly can replace these disinfectants that have been developed to obtain high levels of disinfection where necessary.

Composition for use in accordance with this invention is able to provide adequate levels of disinfection, without irritating the skin. The composition does not irritate the skin due to the low levels of hydrogen peroxide, a mild surfactant and low concentrations of other soft additives that can be used as described above. The solution has a wide range of activity, the degree of which is unexpected, given the germicidal activity of the individual ingredients. The synergistic effect of the ingredients of the solution in accordance with this invention is that it turns out effective disinfectant that is suitable for use on the skin.

In a preferred embodiment, a composition in the form of disinfectant soap, which avoid the use of antimicrobial chemicals, such as triclosan, chlorhexidine, PCMX, etc. Soap can be made in the form of gel soap, soap is La spraying or expanded onto the soap. It can be used for disinfection and cleaning of the skin or hair (shampoo) in General, more specifically for the hands or face, or can be used as a shampoo for animals.

As additional surfactants, to further enhance biocidal ability soap, soap may preferably contain betaine, such as alkyldiphenylamine, allylaminogeldanamycin, such as cocamidopropylbetaine, and/or alkylsulfonates, and/or amine oxide, such as oxide alkyldiphenylamine and/or oxide alkylhydroxylamines, such as dimethylamine oxide, where the alkyl group has 10 to 18 carbon atoms, such as oxide dimethylbenzylamine, the oxide dimethylacetamide and/or oxide dimethylpentylamine.

Another preferred use of the composition includes the use in dentistry and as a solution for rinsing the mouth. Control of infection and inflammation in the mouth and the oral cavity is still an important area, and is still dominated by products based on chlorine, alcohol, and phenol. The majority of these products have significant weaknesses and has a negative effect on living tissue. Compositions in accordance with this invention can effectively replace such products.

To obtain an effective composition for dentistry and solutions for polos is of the mouth, various compounds may be added to the composition to improve its antimicrobial effectiveness, such as antimicrobial essential oils and zinc salts, e.g. zinc chloride, zinc oxide, zinc lactate, or compounds that enhance the practical application, such as glycols, alcohols, edible surfactants, flavorings, perfumes, etc.

This invention also relates to the use of compositions for disinfection and preferably also the cleaning of the substrate. This can be achieved by contact of the substrate with an effective amount of the biocidal composition. In addition to disinfection, the composition is particularly effective for removing stains and dirt, for certain substrates, in combination with odor removal. The substrate may be any surface, space, material, medical device or instrument, hospital equipment, walls, ceilings and/or floors. For example, the composition can be effectively used for disinfection and cleaning of carpets. Preferably the substrate is a substrate on which it is expected the presence of (pathogenic) microorganisms.

Further, the composition can be effectively used for preservation of food, as the washing liquid for meat, poultry and fish, as the washing liquid in the production of beer and dairy products, for example the program of veterinary medicine and animal husbandry, such as the prevention and treatment of mastitis, and for water treatment and water disinfection.

In a preferred embodiment, the composition is represented as the washing liquid, for machines or equipment. Examples of the latter include equipment for food processing, cutting machines, nozzles, installations for the production of beer, baking ovens, installations for the production of dairy products, the nodes for processing fruits and vegetables, plants for the production of juices and soft drinks, etc., medical equipment and instruments, and appliances.

In this embodiment, the composition should have a low foaming. Thus, additional non-ionic and/or amphoteric surfactant, which may be present in the composition should not be visokopropusni surface-active substance. Preferred amine oxides and/or betaines with alkyl chain in the lower intervals, i.e. 8-10 carbon atoms, for example, nitric oxide octyl and/or decollimation. To obtain low foaming the composition in the form of leaching fluid may include a defoamer, such as water-soluble silicone, and/or non-ionic surface-active agent with low foaming, such as alkylpolyoxyethylene ether, for example, selected from the series Propetal from Zschimmer & Shwarz.

Examples

The bactericidal activity of the compositions tested using controlled bactericidal suspension in accordance with European regulations for disinfectants and antiseptics EN 1276 EN 1276: Quantitative testing of suspension for the evaluation of bactericidal activity of chemical disinfectants and antiseptics used in food industry, light industry, household and medical institutions: the testing procedure and requirements). One ml of the test suspension containing approximately 108SOME of the tested microorganism per ml, is added to 8 ml of the test composition, and add 1 ml of water Milli-Q. In some experiments to this suspension add protein according to methods EN 1276 to simulate real dirty conditions. For clean conditions type of 0.3% bovine albumin and dirty conditions 3% bovine albumin.

1, 2 and 5 minutes contact to determine the number of viable bacteria.

In the same way test fungicidal and virucidal activity using tests developed for use with fungi and viruses. For fungi or yeast used tests according to the European standard EN 1275, EN 1650 or EN 13624. Viruses use the test according to the European standard EN 14476.

Biocidal activity of some compositions are those which can be carried using the test bactericidal suspension, the relevant European standard EN 12054 for chemical disinfectants and antiseptics, in particular products for hygienic and surgical solutions to treat the hands and rinses for hands. One ml of the test suspension containing at least 1 × 108CFU per ml of bacteria, mixed with 9 ml of the test composition. First, the original suspension count by breeding to calculate levels. To test solutions for hand applied undiluted test suspension. For conditioners for hands used thinner on the basis of hard water.

Example 1

Various compositions tested to determine the biocidal activity and compared with a standard, commercially available solutions of H2O2without additives, with the exception of the stabilizers. The tested compositions include aliphatic phosphate ester with 8-10 carbon atoms and 4 moles of ethylene oxide (EO), for example sold by Uniqema International under the trade name Monafax 1214. There is also a stabilizer of hydrogen peroxide in the form of disuccinate of trinitrotoluene available from Octel under the trade name OctaQuest (OQ). the pH of this solution varies from 2 to 4.5. The test results are presented in table 1 below. It turns out that Monafax significantly enhances the biocidal activity of whom is osili.

Table 1
test suspension1 min2 min5 min
1,0% H2O2+ 0,02% OQ
Salmonella typhimurium4,80E + 08>1000>1000>1000
Escherichia coli6,00E + 07>1000>10001000
Pseudomonas aeruginosa1,25E + 08>1000>1000172
Staphylococcus aureus5,35E + 08>1000>1000560
Enterobacter cloacae7,50E + 08>1000>1000>1000
1,5% H2O2+ ,02% OQ
Salmonella typhimurium4,80E + 08>1000>10001000
Escherichia coli6,00E + 07>10001000688
Pseudomonas aeruginosa1,25E + 0846130
Staphylococcus aureus5,35E + 08>10001000678
Enterobacter cloacae7,50E + 08>1000>1000864
1,75% H2O2+ 0,02% OQ
Salmonella typhimurium4,80E + 08>1000>1000>1000
Escherichia coli6,00E + 07>1000>1000408
Pseudomonas aeruginosa1,25E + 0867021048
Staphylococcus aureus5,35E + 08>1000876272
Enterobacter cloacae7,50E + 08>1000>10001000
2% H2O2+ 0,02% OQ
Salmonella typhimurium4,80E + 08>1000>10001000
Escherichia coli6,00E + 07>10001000576
Pseudomonas aeruginosa1,25E + 0810006502
Staphylococcus aureus5,35E + 08>1000528192
Enterobacter cloacae 7,50E + 08>100010001000
0,6% H2O2+ 0,7% Monafax 1214 + 0,02% OQ
Salmonella typhimurium4,80E + 080
Escherichia coli6,00E + 070
Pseudomonas aeruginosa1,25E + 080
Staphylococcus aureus5,35E + 080
Enterobacter cloacae7,50E + 080
1,0% H2O2+ 1% Monafax 1214 + 0,02% OQ
Salmonella typhimurium4,80E + 080
Escherichia coli/td> 6,00E + 070
Pseudomonas aeruginosa1,25E + 080
Staphylococcus aureus5,35E + 080
Enterobacter cloacae7,50E + 080
1,0% H2O2+ 0,5% Monafax 1214 + 0,02% OQ
Salmonella typhimurium4,80E + 080
Escherichia coli6,00E + 070
Pseudomonas aeruginosa1,25E + 080
Staphylococcus aureus5,35E + 080
Enterobacter cloacae7,50E + 080
1,5% H2O2+ 0,1% Monafax 1214 + 0,02% OQ
Salmonella typhimurium1,00E + 080
Escherichia coli4,00E + 070
Staphylococcus aureus1,35E + 080
Enterobacter cloacae1,15E + 080
0,5% H2O2+ 0,2% Monafax 1214 + 0,02% OQ
Salmonella typhimurium1,00E + 080
Escherichia coli4,00E + 070
Staphylococcus aureus1,35E + 080
Enterobacter cloacae1,15E + 080
0,5% H2O2+ 0,5% Monafax 1214 + 0,02% OQ
Salmonella typhimurium1,00E + 080
Escherichia coli4,00E + 070
Staphylococcus aureus1,35E + 080
Enterobacter cloacae1,15E + 080

Without Monafax, only a few bacterial types show more than 5 log reduction within 5 minutes, which is the norm testing according to standard EN 1276. With Monafax, log 6 or even log 7 reduction reaches the I in 1 minute.

A composition containing 1% H2O2and 1% Monafax able to kill these germs in 30 seconds: Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus hirae, Proteus Vulgaris, Staphylococcus epidermidis, Streptococcus pyogenes, Salmonella typhimurium, Shigella sonnei, Lysteria monocytogenes, Legionella pneumoniae, Campylobacter jejuni, Klebsiella pneumoniae, Enterococcus faecium, Proteus mirabilis, Saccharomyces cerevisiae.

Example 2

Efficiency Monafax 1214 compare the effectiveness of two widely used non-ionic surfactants, ethoxylated fatty alcohol Dehydol LT7 (C12-18 with 7 EO; Cognis) in 0.6% and Arlasolve 200 from Uniqema, non-ionic surfactants with a high products HLB (isohexadecane ether of polyoxyethylene) 0.7%, and a pH of about 5 with the use of test EN 1276. The test results presented in table 2 below. It is clear that the biocidal activity of compositions containing Monafax, much better than biocidal activity of compositions containing ethoxylated fatty alcohol nonionic surfactant with a high products HLB.

Table 2
Test suspension1 min2 min5 min
1,5% H2O2+ 0,1% Monafax 1214 + 0,02% Q
Escherichia coli4,00E + 070
Staphylococcus aureus1,35E + 080
1,5% H2O2+ 0,6% Dehydol LT7 + 0,02% OQ
Escherichia coli1,30E + 08>5009612
Staphylococcus aureus1,74E + 0922019660
1,5% H2O2+ 0,7% Arlasolve 200 + 0,02% OQ
Escherichia coli1,30E + 08>500>50048
Staphylococcus aureus1,74E + 0930420472

Example 3

The effectiveness of the solutions in accordance with this invention compared with the efficiency of the oxides and the ina, the group of surfactants known in the art (for example: US 6479454 (Ecolab) and US 6444230 (Chemoxal) as having a significant biocidal activity in hydrogen peroxide solution, even at low concentrations.

To simulate real dirty conditions add protein according to methods EN 1276 the tested bacterial suspensions. For clean conditions type of 0.3% bovine albumin and dirty conditions 3% bovine albumin. Efficiency Monafax 1214 compare with the efficiency of N,N-dimethylbenzylamine-N-oxide (Barlox 10s from Lonza Ltd.). Apply the concentration of H2O21.2% and a concentration of 0.6% of the respective surfactants. The solution containing Monafax has a pH of about 2.3, and a solution containing Barlox 10s has a pH of about 5. The test results presented in table 3 below. It is clear that the biocidal activity of compositions containing Monafax, is essential.

Table 3
test suspensionnetdirty
2 min5 min2 min 5 min
Barlox 10s (Lonza)
Enterococcus hirae3,80E + 088061
Bacillus cereus2,20E + 08>300>300>300>300
Candida albicans3,00E + 08300250>300>300
Staphylococcus aureus5,50E + 08>300>300>300>300
Lysteria monocytogenes3,00E + 08>300>300>300>300
Monafax 1214 (Uniqema)the
Lysteria monocytogenes3,00E + 083000
Enterococcus hirae2,00E + 080000
Escherichia coli3,00E + 080000
Pseudomonas aeruginosa1,00E + 080000
Staphylococcus aureus5,50E + 080000
Enterobacter cloacae3,00E + 080000
>300 mean number of colonies that can't is to be calculated (excessive)

Example 4

It is also clear that the solutions in accordance with this invention is significantly more stable than the solutions containing only hydrogen peroxide and a commercially available stabilizers of hydrogen peroxide. Testing the stability of 0.6% solution of hydrogen peroxide in the presence of commercially available stabilizers. The test parameters include a temperature of 37°C for 30 days. The test results presented in table 4 below. The concentration of H2O2measured using titration with potassium permanganate. The control contains only H2O2with a stabilizer added by the manufacturer (Solvay Chemicals).

Adding Monafax 1214 improves the stability of the hydrogen peroxide solution even in the presence of commercially available stabilizers of hydrogen peroxide.

Table 4
30 days at 37°WithOctaquest 0,02%Acetanilide 0,05%Deqest 0,20%control
without Monafax 1214-6,1%-2,3%-13,2%-3,4%
c Monafax 1214of-1.0%0,0%0,0%-0,4%

Example 5

A solution containing 0.5% hydrogen peroxide, 0.5% of aliphatic of ester phosphate (Monafax 1214 from Uniqema International), 0.5% of Acetanilide as a stabilizer of hydrogen peroxide and 0.6% of ethoxylate C10 alcohol (8 moles EO) (Lutensol XL 80 from BASF) and potassium hydroxide to a pH of 4.5, is prepared and used as an antimicrobial agent for treatment of hands.

The peroxide0,5%
Monafax 1214 (Uniqema)0,5%
Lutensol XL 80 (BASF)0,6%
Acetanilide0,5%
The potassium hydroxideto pH 4.5
Demineralized waterup to 100%

The solution tested for antimicrobial activity using methods of test EN 12054 on S. aureus, P. aeruginosa, E. hirae and E. coli, and it shows more log 3 reduction, which is the norm for antiseptic hand.

Example 6

Receive antimicrobial hand soap contains the following ingredients:

1.5% hydrogen peroxide

1,5% Monafax 1214 (aliphatic ester phosphate)

2% Tego Betaine F 50 (alkylamidoamines)

1% Natrulon H-10 (polyglyceryl)

In the composition add a buffer with NaOH to pH 4,5.

Biocidal activity (EN 1276 5 minutes, expressed as logarithmic ratios of reduction of colony forming units per ml) is the following:

cleandirty
E. coli ATCC 25922>6,2>6,2
Pseudomonas aeruginosa ATCC 15442>6,2>6,2
Enterococcus hirae nATCC 10541>5,6>5,6

Example 7

Cook the liquid for washing machines, containing the following ingredients:

0,4% Monafax 1214 (Uniqema)

0,3% Barlox 10s (Lonza Inc.)

0,5% Propetal 120 (Zschimmer &Schwarz)

0.05% of Surfadone LP 100 (International Specialty Products;

0,2% Dequest 2010 (Solutia)

This fluid is tested according to the standard EN 1276, and it shows the following biocidal activity (expressed as logarithmic ratios of reduction of colony forming units per ml):

clean
dirty
E. coli ATCC 25922>5>5
Pseudomonas aeruginosa ATCC 15442>5>5
Enterococcus hirae nATCC 10541>5>5

Example 8

The following test compositions in 1.5% hydrogen peroxide solution added 0.8% of some of the publicly available compounds of formula 1. Table 5 shows the log reduction of Staphylococcus aureus.

Elementis
Table 5
Data on the effectiveness of various compounds of formula 1
ConnectionLog reduction
Staph. aureus
ManufacturerType1 min5 min
BASFMaphos 60A>6>6
Zschimmer &SchwarzPhosfetal 2015,5>6
VPDZ 6/1003,05,5
ElementisVPBZ 5/100>6>6

Example 9

A composition containing 2% H2O2and 1% Monafax 1214, prepared and tested against Vacciniavirus, Feline Calici Virus and Adenovirus according to the standard EN 14776:

EN 14476 - Chemical disinfectants and antiseptics - quantitative testing virucidal suspension for chemical disinfectants and antiseptics used in medicine - methods of testing and requirements (phase 2/step 1).

Unexpectedly, the composition comprising Monafax, demonstrates potent virucidal activity (table 6), while the standard commercially available H2O2without adding Monafax, shows significantly lower log reduction (table 7).

Table 6
1 minute3 minutes
Vacciniaviruslog>5,4
Feline Calici Viruslog>5,4
Adenoviruslog>5,4

Table 7
3 minutes5 minutes10 minutes
Feline Calici Virus2% H2O2log 0,2log 0,9
Adenovirus2% H2O2log 0,6log 0,6
Adenovirus3% H2O2log 0,5log 0,6

Example 10

A solution containing 7% H2O2and 4% Monafax 1214, is prepared and then tested against fungi according to the European standard EN 1275, EN 1650, EN 13624.

EN 1275 - Chemical disinfectants and antiseptics - quantitative suspension checked for the assessment of basic fungicidal or basic Drogichin activity of chemical disinfectants and antiseptics - test Methodology and requirements phase 1).

EN 1650 - Chemical disinfectants and antiseptics - quantitative suspension checked for the assessment of basic fungicidal activity of chemical disinfectants and antiseptics used in food industry, light industry, household and medical institutions - testing Methods and requirements (phase 2, step 1).

EN 13624 - Chemical disinfectants and antiseptics - quantitative suspension checked for the assessment of basic fungicidal activity of chemical disinfectants and antiseptics used in medicine - methods of testing and requirements (phase 2, step 1).

The test results are shown in tables 8 and 9.

Table 8
The test results for Candida albicans ATCC 12031 in simulated clean and dirty conditions with a contact time of 5 and 15 minutes
5 minutes15 minutes
EN 1275log 3,3log > 5,3
EN 1650/EN 13624cleanlog 3,2log > 5,3
EN 1650/EN 13624dirty log 2,5log > 5,3

Table 9
The test results for Aspergillus niger ATCC 16404 in simulated clean and dirty conditions with a contact time of 5 and 15 minutes
5 minutes15 minutes
EN 1275log 4,5log > 5,3
EN 1650/EN 13624cleanlog > 5,4log > 5,3
EN 1650/EN 13624dirtylog 4,4log > 5,3

1. The use of a composition containing hydrogen peroxide at a concentration of 0.05-50% (wt./wt.) and the connection structure of formula 1:
(OH)(2-m)(X)(O)P-[(O)p-(R')q-(CH(Y)-CH2-O)n-R]mor its salt, where X is H or HE; each Y is independently N or CH3; m is 1 and/or 2; each p and q independently are 0 or 1, provided that when p is 0, q is 1; each n is independently equal to 2 to 10; each R' independently is alkilinity radical containing 1-18 carbon atoms; each R independently is H or alkyl radical containing 1-18 carbon atoms; and R'+R≤20;
at stake is entrale of 0.01-60% (wt./wt.), as a biocidal composition.

2. The use according to claim 1, where the connection structure of formula 1 represents a mixture of compounds in which m is 1 and compounds in which m is equal to 2, where the compounds in which m is 1 are at least 50% of the mixture, preferably at least 60%, more preferably at least 70%, even more preferably at least 80%, most preferably at least 90%.

3. The use according to claim 1, where the connection structure of formula 1 is a compound in which m is 1.

4. The use according to any one of claims 1 to 3, where X is an and Y is N.

5. The use according to claim 1, where n is 2-8, preferably 2-6, more preferably 4-6, most preferably 4.

6. The use according to claim 1 wherein R'+R contains 4-18 carbon atoms, preferably 4-16 atoms, more preferably 6 to 14 carbon atoms, even more preferably 8-12 carbon atoms, even more preferably 8-10 carbon atoms.

7. The use according to claim 1 where R' and R are radicals with a straight chain.

8. The use according to claim 1, where p is 1 and q is 0.

9. The use according to claim 1, where the hydrogen peroxide concentration is 0.05-8% (wt./wt.), preferably 0.1 to 7%, more preferably 0.2 to 5%, most preferably 0.3 to 3%.

10. The use according to claim 1, where the concentration of the compounds of structure of formula 1 is 0.01-10% (wt./wt.), preference is sustained fashion of 0.05-5%, most preferably 0.1 to 2%.

11. The use according to claim 1, where the concentration of hydrogen peroxide and compounds of structure of formula 1 is selected so that the mass ratio of hydrogen peroxide and compounds of structure of formula 1 is from 10 to 0.1, preferably from 5 to 0.2, more preferably from 2 to 0.5.

12. The use according to claim 1, where the hydrogen peroxide is formed by the connection forming peroxide.

13. The use according to claim 1, where the composition has a pH 0-9, preferably 1.5 to 7, more preferably 2-5.

14. The use according to claim 1, where the composition also contains a stabilizer of hydrogen peroxide, preferably cationic complexing compound, more preferably, in a concentration of from 0.01 to 20% (wt./wt.).

15. The use according to claim 1, where the composition also contains non-ionic and/or amphoteric surfactant, preferably in a concentration of 0.005 to 40% (wt./wt.).

16. The application indicated in paragraph 15, where the surface-active agent is an amine oxide and/or betaine.

17. The use according to claim 1, where the composition also contains a corrosion inhibitor, preferably in a concentration from 0.01 to 20% (wt./wt.).

18. The use according to claim 1 for any purposes that require disinfecting and/or sanitization, preferably, in combination with a cleaning and/or bleaching and/or conservation activity.

19. The use according to claim 5 or 16, where the composition is a disinfectant soap, preferably a gel soap, soap for spraying or expanded onto the soap.

20. Use PP-17, where the composition is a sterile liquid for sterilization instrument or hard surfaces, preferably by soaking or spraying on tools or hard surface.

21. Biocidal composition comprising hydrogen peroxide in a concentration of 0.05-50% (wt./wt.) and the connection structure of formula 2:
(OH)(X)(O)P-O-(CH(Y)-CH2-O)n-R, or its salt,
where X is H or HE, Y is N or CH3, n = 4-8, and R is an alkyl radical containing 4-14 carbon atoms in a concentration of 0.01-60% (wt./wt.).

22. The composition according to item 21, where X is HE, Y is H, n is 4-6, and R is an alkyl radical containing 6 to 12 carbon atoms, preferably 8-10 carbon atoms.

23. Composition according to any one of p or 22, where R is an alkyl radical with a straight chain.

24. The composition according to item 21 also contains non-ionic and/or amphoteric surfactant and/or stabilizer of hydrogen peroxide.

25. The use of a composition according to item 21 for any purpose requiring disinfecting and/or sanitizing activity, preferably, in combination with a cleaning and/or bleaching and/or conservation activity.



 

Same patents:

Detergent // 2422499

FIELD: chemistry.

SUBSTANCE: invention can be used on enterprises of the food industry to wash equipment and production facilities. Said detergent contains the following in wt %: sodium hydroxide 15-25, potassium hydroxide 10-15, sodium metasilicate (liquid glass) 1-3, nonionic surfactant (alkylglycoside C8-C10) 3-7, nonionic surfactant (alkyldimethylamine oxide) 1-5, potassium carbonate 1-3, sodium gluconate 0.1-3, sodium tripolyphosphate 0.1-1, ethylene glycol 1-3 and water - the rest.

EFFECT: high detergent power, wide range of dirt removed, high protection of metal from corrosion and reduced detergent consumption.

2 tbl

FIELD: medicine.

SUBSTANCE: compound possesses improved bactericidal and viricidal activity. A disinfectant compound contains polyguanidine compound, quaternary ammonium compound and water, as quaternary ammonium compound, synergetic mixture of any two or three quaternary ammonium compounds of: alkyl benzyl ammonium chloride, or dialkyl dimethyl ammonium chloride, or alkyl trimethyl alkyl chloride, or trialkyl methyl alkyl chloride, or N-heterocyclic quaternary ammonium compound: N-lauryl pyridinium chloride, N-cetyl pyridinium chloride, polyethylene pyrrolidinium chloride, N-alkyl-N-ethyl piperidinium ethyl sulphate is used. The mass ratio for any two quaternary ammonium compounds is 1:(1÷3.5); for any three quaternary ammonium compounds (1:1:1) - (1:2:3), and the mass ratio for polyguanidine compound and mixed quaternary ammonium compounds 1: (0.25-4.0). As polyguanidine compound use poly-(4,9- guanidine dioxadodecane) (PGDD) phosphate, or poly-(4,9- guanidine dioxadodecane) chloride, or poly-(4,9- guanidine dioxadodecane) gluconate, or poly-(4,9- guanidine dioxadodecane) citrate, or poly-(4,9- guanidine dioxadodecane) benzoate, or polyhexamethylene guanidine (PHMG) citrate, or polyhexamethylene guanidine gluconate, or polyhexamethylene guanidine formate, or polyhexamethylene guanidine benzoate, or polyhexamethylene guanidine phosphate, or polyhexamethylene guanidine chloride, or polytrimethylene diguanidine, or poly-(3,6-dioxaoctaguanidine) chloride, or poly-(3,6-dioxaoctaguanidine) phosphate, or poly-(3,6-dioxaoctaguanidine) gluconate, or poly-(3,6-dioxaoctaguanidine) benzoate, or poly-(4,7,10-trioxatridecane guanidine) chloride, or poly-(4,7,10-trioxatridecane guanidine) phosphate, or poly-(4,7,10-trioxatridecane guanidine) gluconate, or poly-(4,7,10-trioxatridecane guanidine) benzoate, or 1,6-biguanidinohexane dihydrochloride.

EFFECT: enhancement of the disinfectant, spectrum of antimicrobic activity and intensification of biocide properties.

2 cl, 3 tbl

FIELD: medicine.

SUBSTANCE: preparation can be applied as antimicrobial, disinfecting and sterilising means used, for instance, as skin antiseptic for procession of hands, procession of injection field, elbow bends of donors, which has fungicidal and virulicidal action when used internally. Preparation is based on water solution of potassium chlorate (KClO3) and sulphuric acid (H2SO4). The greater part of preparation base is constituted by water; boiling point of preparation equals 103.3 degrees Celcius.

EFFECT: obtaining antiseptics with absence of toxicity when applied on living tissues, preparation stability, long terms of storage without reduction of activity and absence of odour.

FIELD: medicine; veterinary science.

SUBSTANCE: disinfectant "ExtraDes" contains mixed quaternary ammonium salts (QAS) - didecyldimethylammonium chloride (30%) and alkyldimethylbenzylammonium chloride (20%), and dye - 0.005% and water - to 100%. Invention is aimed at provided extension of operational possibilities due to increased disinfectant activity concerning all known viruses - human pathogen, including, enteral and parenteral hepatitis viruses, HIV, poliomyelitis, adenovirus, severe acute respiratory syndrome (SARS), human influenza and bird influenza H5N1, herpes.

EFFECT: invention provides disinfection at lower concentration of working solution and reduces disinfecting time.

3 tbl

FIELD: medicine, in particular sanitary.

SUBSTANCE: claimed detergent contains disinfecting agent, including alkylmethylbenzylammonium chloride with polyhexamethyleneguanidine hydrochloride and/or non-ionic surfactant, water and high molecular polyoxyethylene of molecular mass 1x106-1x109 and/or high molecular polyacrylamide of molecular mass 1x106-20x106. Additionally detergent may contain flavor, colorants and additive selected from group containing ethanolamines, urea, platinum complex compounds, fullenene complex compounds with polyoxyethylene or polyvinyl pirrolydone, silver or cupper nanoparticles, dibasic acid or low molecular alcohol dialdehydes, additive, selected from group containing ethanolamine, diethanolamine, triethanolamine, monoethylmonoethanolamine, diethylmonoethanolamine, methyldiethanolamine, and diisopropanolamine in specific component ratio.

EFFECT: detergent of increased biocide activity.

34 cl, 1 ex, 6 tbl

Disinfecting agent // 2297248

FIELD: medicine.

SUBSTANCE: invention relates to agents used for disinfection. Disinfecting agent comprises quaternary ammonium compound and/or derivatives of polyhexamethylene guanidine, and/or N,N-bis-(3-aminopropyl)-dodecylamine, nonionogenic surface-active substance and salts of ethylenediaminetetraacetic or hydroxyethylenediphosphonic acids, and dye, perfume and water also wherein components are taken in the definite ratio, wt.-%. The proposed disinfecting agent provides high antibacterial properties, it shows good detergent properties, it stable in storage and safe in using in presence of humans and effective in using working solutions in the small concentrations.

EFFECT: valuable and effective properties of agent.

2 cl, 3 tbl, 17 ex

FIELD: biotechnology, agent for combating of domestic dust mites and mite allergens in process of fabric article washing.

SUBSTANCE: claimed method includes blending of benzyl benzoate with surfactants such as Tween-80 and Tween-30 and water and introducing of obtained acaricidal mixture into detergent. 33-34 % Ammonium sulfate aqueous solution is introduced into mixture of benzyl benzoate, Tween-80 and Tween-30 in ratio of 3:2:2 in amount of 76.6 ml per 100 ml of mixture. Further mixture is stirred to produce homogenous acaricidal emulsion followed introducing thereof into detergent in amount of 1-2 ml per 1 l of detergent at 30-60°C. Obtained preparation has storage time of 1 year in dark bottles.

EFFECT: agent with decreased toxicity, prolonged storage time and increased acaricidal activity.

3 ex

FIELD: biotechnology, in particular agent for removing of mite allergens and domestic dust mites.

SUBSTANCE: claimed method includes blending of benzyl benzoate with surfactants and water and introducing of obtained acaricidal mixture into detergent. As surfactants Tween-80 and Tween-20 are used. Copper sulfate and distilled water are introduced into mixture of benzyl benzoate, Tween-80 and Tween-20. All components are used in specific ratio. Abovementioned components are intensively agitated to produce homogenous acaricidal emulsion. Obtained emulsion are introduced into detergent in amount of 1-2 ml per 1 l of detergent at 30-60°C.

EFFECT: agent of decreased toxicity and increased acaricidal activity.

1 tbl, 3 ex

FIELD: medicine, in particular disinfections and cleaning of medicine articles, surgery tools, hospital clothes, etc, in bacterial, viral and fungus infections.

SUBSTANCE: claimed composition contains (mass %): glutaric aldehyde 3.8-4.2; ortho-phenylphenol 2.8-3.2; ortho-benzyl-para-chlorophenol 2.8-3.2; propylene glycol 60-70; ethanol 5-10; benzoic acid 2.8-3.2; sodium benzoate 2.8-3.2; lauryl sulfate 10-15; water 5-10.

EFFECT: safe composition of increased antibacterial activity.

4 tbl, 1 ex

Disinfecting agent // 2279275

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a disinfecting agent comprising the following components, wt.-%: catamine AB, 2.0-12.0; alkacetam, 4.0-8.0, and water, the balance, but the agent can comprise the following additional components, wt.-%: polyethylene glycol of molecular mass 400-1500 Da, 1.0-5.0; ethylenediaminetetraacetic acid disodium salt, 1.0-2.0; sodium carbonate or hydrocarbonate, 1.0-5.0; isopropyl alcohol, 1.0-5.0, and cetylpyridinium chloride, 0.01-0.10. Proposed disinfecting agent possesses the bactericidal effect in the concentration 0.05-0.10 wt.-% at exposition period 15-30 min, and the fungicide effect also in the concentration 0.1-0.5 wt.-% at exposition period 60 min. Invention provides enhancing the bactericidal and fungicide activity of the disinfecting agent and reducing its toxicity.

EFFECT: improved and valuable properties of agent.

2 cl, 2 tbl, 20 ex

FIELD: chemistry.

SUBSTANCE: aqueous composition has pH equal to or less than 3, and contains the following ingredients (per total weight of the composition) : a) 0.05-20 wt % polymer thickener containing 20-100000 monomer links and an average of at least 0.8-COOR groups per monomer link, where for each separate -COOR group, R is independently selected from H, OH, and a carbon-containing group, b) 0.05-30 wt % hydrogen peroxide in terms of H2O2, c) 0.5-60 wt % one or more aliphatic carboxylic acids containing 1-8 carbon atoms, their alkyl esters, anhydrides and/or peroxy acids. Content of active oxygen, which is ensured by presence of ingredients a) and c) is equal to at least 0.02 wt % (per total weight of the composition).

EFFECT: obtaining a stable aqueous composition with low pH for cleaning different surfaces and for bleaching textile materials or paper.

15 cl, 10 ex, 3 tbl

FIELD: chemistry.

SUBSTANCE: sodium percarbonate particles covered by a cladding have a core of sodium percarbonate obtained via fluidised bed granulation. The cladding contains sodium sulphate and sodium carbonate in weight ratio ranging from 95:5 to 75:25 in relative amount of at least 80 wt %.

EFFECT: improved detergent action of sodium percarbonate when used as detergent component with simultaneous increase in stability when stored with detergents.

12 cl, 5 tbl

FIELD: chemistry.

SUBSTANCE: sodium percarbonate particles are covered by a cladding which contains sodium sulphate in form of a high-temperature phase of sodium sulphate and/or in form of a high-temperature phase of a double salt of formula Na4(SO4)1+n(CO3)1-n, where n is a number ranging from 0 to 0.5.

EFFECT: high stability during storage.

8 cl, 4 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: sodium percarbonate particles are covered by a cladding which contains anhydrous sodium sulphate in amount of 70-99.8 wt % and sodium borate in amount of 0.2-20 wt % and where said cladding accounts for 1-10% of the total weight of one particle of sodium percarbonate.

EFFECT: high stability during storage when using sodium percarbonate particles as a component of detergent and cleaning agents.

9 cl, 2 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a bleaching system for household textile items containing at least one bleaching agent, where the bleaching system is selected from peroxybenzoic acid, peroxy-6-naphthoic acid, peroxylauric acid, peroxystearic acid, phthalimido peroxycaproic acid, 6-phthalimido peroxyhexanoic acid, nonylimido peroxyamber acid, nonylimido peroxyadipic acid, 1,12-diperoxydodecanoic acid, 1,9-diperoxyazelaic acid, diperoxyisophthalic acid and 2-decyldiperoxybutane-1,4-diacid and coated by a shell in form of a layer of a polymer with urethane and urea groups, where a prepolymer with terminal NCO groups is obtained from macrools, ionic or potentially ionic polyols and polyisocyanates used in excess, said prepolymer being subjected to reaction with compounds which contain at least two amine groups which are reactive towards isocyanate with ratio of NCO groups to NH groups less than or equal to 1:1, after which said polymer is obtained via neutralisation.

EFFECT: obtaining a novel bleaching system.

11 cl, 2 ex

FIELD: chemistry.

SUBSTANCE: cleaning compositions contain organic catalysts having improved enzyme compatibility and having the following formulae: where each R1 independently denotes a branched alkyl group selected from a group comprising 2-butyloctyl, 2-pentylnonyl, 2-hexyldecyl, isodecyl, isotridecyl and isopentadecyl, or a linear alkyl group containing 11-18 carbon atoms. The composition also contains one or more auxiliary ingredients.

EFFECT: cleaning compositions with efficient bleaching at low water temperature.

15 cl, 16 ex

FIELD: chemistry.

SUBSTANCE: synthetic detergent with low environmental hazard contains sodium tripolyphosphate, anionic surfactant - sodium soap based on high fatty acids, carboxymethyl cellulose, sodium silicate, optical bleaching agent, fragrance component, sodium sulphate and water. The detergent also contains a nonionic surfactant - oxyethylated fatty alcohols, collagen dissolution products obtained by using leather production wastes (leather cuttings), sodium perborate and sodium carbonate. All components are taken in a defined ratio.

EFFECT: invention enables production of a synthetic detergent with low environmental hazard, good detergent action and low foaming capacity.

3 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to pellets which contain diacyl peroxide particles inside a matrix, a method of preparing such pellets and detergents containing such pellets. The pellets contain a matrix made from at least one metal ion-cross-liked polysaccharide and diacyl peroxide particles put inside the said matrix. The pellets are obtained through drop-wise addition of an aqueous suspension in which diacyl peroxide particles are suspended and in which at least one metal ion-cross-linked polysaccharide is dissolved to a solution which contains polysaccharide cross-linking metal ions.

EFFECT: obtaining pellets in which diacyl peroxide is in a form which ensures its reliable production and storage.

11 cl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to aqueous liquid compositions for bleaching, cleaning and disinfecting surfaces. The invention describes an aqueous liquid bleaching composition which contains hypochlorite, a quaternary ammonium salt of formula: R1R2R3R4N+X-, where R1 - C10-C20 alkyl; R2, R3 and R4 - C1-C3 alkyl; X is an inorganic anion, and a viscousifying system which contains an amine oxide as a surfactant and a fatty acid. Described also is a method of imparting prolonged antibacterial activity on a solid surface using the said composition and a container for preparing the said composition.

EFFECT: obtaining a composition which retains its activity and stability during storage for 4 weeks.

16 cl, 2 tbl, 4 ex

FIELD: chemistry.

SUBSTANCE: cleaning compositions contain organic catalysts having the formula (i), (ii) given in the formula of invention, or mixtures thereof. In the formula G is selected from -O-, -CH2O-, -(CH2)2- and -CH2-, R1 is selected from H or C1-C4 alkyl, each R2 is independently selected from C4-C8 alkyl, benzyl, 2-methylbenzyl, 3-methylbenzyl, 4-methylbenzyl, 4-ethylbenzyl, 4-isopropylbenzyl and 4-tert-butylbenzyl.

EFFECT: improved compatibility of organic catalysts with enzymes.

18 cl, 18 ex

FIELD: chemistry.

SUBSTANCE: solution contains the following in g/l: potassium hydroxide 20-40, potassium pyrophosphate 15-25, propanol 5-10, press liquor 900-1000 ml/l, o,o-dimethyl-o-(3-methyl-4-nitrophenyl)thiophosphate 0.7-1.2, 2,5-dichloro-3-nitrobenzoic acid 1.2-2.9, water - up to 1 l.

EFFECT: high degree of purification and high anti-corrosion action.

2 tbl

Up!