Phosphatised alkanol, its application as hydrotrope, and detergent composition containing said compound
SUBSTANCE: invention refers to phosphatised 2-propylheptanol alkoxylates containing 2-4 ethylene oxide links and 1-3 phosphoric acid residues in the form of phosphoric or polyphosphoric acid or acid salt ethers, and to application of phosphatised 2-propylheptanol or phosphatised 2-propylheptanol alkoxylates containing 1-3 phosphoric acid residues, 1-20 ethylene oxide links and 0-3 propylene oxide and/or butylenes oxide links in the form of phosphoric or polyphosphoric acid or acid salt ethers, as hydrotrope for C8-C18 alcohol alkoxylate containing 1-20 ethylene oxide links and 0-3 propylene oxide and/or butylenes oxide links, in alkaline solution, especially in compositions for commercial cleaning of solid surfaces.
EFFECT: obtainment of novel hydrotropes and efficient detergent compositions based on them.
12 cl, 7 ex, 12 tbl
The present invention relates to the use of phosphated 2-propylheptanol or phosphated of alkoxylate 2-propylheptanol as hydrotropes in aqueous alkaline solutions for alkoxylates C8-C18-alcohols containing 1-20 ethylenoxide links. The invention also relates to the phosphated alkoxylated 2-propylheptanolper seand alkaline cleaning composition, comprising a phosphated 2-propylheptanol and/or phosphated alkoxylated 2-propylheptanol as hydrotropes.
The ability of an aqueous solution evenly to cover the surface or so-called wetting ability is important for many applications. For example, the composition for cleaning hard surfaces benefit from a good wetting of the surface. Good wetting is also desirable for washing and processing methods sabrosky and mercerized. Nonionic surfactants, as is known, are a good wetting and often present in compositions for cleaning hard surfaces. Most often, the composition for cleaning hard surfaces also contains alkaline components. Many nonionic surfactants are insufficiently soluble in solutions with a high content of electrolytes, such as alkali and/or alkaline complexing agents and, with edutella, require the presence of hydrotropes to increase solubility. A number of hydrotropes for nonionic surfactants are described in various publications. Examples of such hydrotropes are ethanol, ecological sodium, coolcullen sodium, Alkylglucoside and phosphated alkoxysilane alcohols.
In U.S. patent 5145597 described alkaline detergent suitable for cleaning mechanical equipment. Data alkaline cleaners include hydrotap based on the ester of phosphoric acid and nonionic surfactant, but in your example is not specified, any ester of phosphoric acid was used.
In U.S. patent 4493782 described cleaning composition containing ethoxylated ester of phosphoric acid derived from alcohol, the alkyl chain of which has from 8 to 12 carbon atoms, and the alcohol amoxilbuy 2-4 moles of ethylene oxide (EO). This ether phosphoric acid is mixed with another ester of phosphoric acid derived from butanol + 2EO, the latter ester of phosphoric acid is added to stabilize the formulation.
U.S. patent 4137190 discloses a detergent composition comprising non-ionic surfactant and synergistic hydrotron mixture. In the working examples use a combination of P2O5-phosphated phenol + 6EO and PF is-phosphated butanol + 1EO or PFC-phosphated isoamyl alcohol + 4EO.
U.S. patent 3294693 reveals hydrotropic to solubilize polietilenoksidnoy nonionic surfactants in building solutions. Hydrotropes are surface-active materials, which contain more than 85% of primary esters of phosphoric acid. These esters obtained by reaction between PFC (polyphosphoric acid) and ethoxylated C6-C10the alkyl phenol or ethoxylated C10-C18-alcohol with 1-20 moles of EO. All the working examples used ethoxylates phosphated of the op.
The patent BE 632444 relates to alkaline detergents, which includes surface-active nonionic adducts of polyethylene oxide obtained by the accession of ethylene oxide to the alcohol, alkylamino or alkyl phenol, and hydrotap, which is a phosphate alkoxysilanes alkylphenol having 6 to 10 carbon atoms in the alkyl group or phosphate alkoxysilanes alcohol having 10 to 18 carbon atoms in the alkyl chain, and hydrotropic material contains 90% of the primary ester of phosphoric acid. In the working examples as hydrotropes used several phosphated alkoxysilane ALKYLPHENOLS, as well as phosphated dodecyloxy alcohol + 15EO and phosphated stearyl alcohol + 7,5EO to solubilize the op + 10 EO.
Esters of orthophosphoric acid, is received from the spirits which was amoxilonline with ethylene oxide in amounts up to 10, preferably 5 moles, are disclosed in patent EP-A-256427 as dispersing agents for pigments. Among these alcohols mentioned 2-propylheptanol.
Alkali metal salts of mono - and diesters of orthophosphoric acid, obtained from a number of alcohols are disclosed in patent CH-A-481953 as surface-active agents used in obtaining durable latex by emulsion polymerization vinylchloride monomers. Propylheptyl mentioned as one possible alkyl substituent in these phosphates.
However, there is still a need for new effective hydrotropic that are suitable for certain songs, because not all hydrotropic and nonionic substances are compatible to produce clear, stable solutions and optimal performance when considering the application. In particular, in some cases, alkaline solutions containing nonionic surfactant, derived from alkoxysilanes alcohol with branched alkyl, and hydrotap, will be separated upon dilution. An example of such alkoxylated alcohols are alkoxylated 2-propylheptanol, where tests showed that transparent and homogeneous alkaline concentrates containing acceleratedly adducts of 2-propylheptanol and hexing ICSID and/or activemanagement as hydrotropes, becomes turbid or exfoliate when they will be diluted to obtain ready-to-use solutions.
The present invention is to find new hydrotap, which is effective for obtaining a transparent homogeneous concentrated alkaline compositions containing alkoxylate C8-C18-alcohols containing 1-20 ethylenoxide links, especially alkoxylate 2-propylheptanol, and composition will remain homogeneous upon dilution, where the compositions have a good cleaning effect.
It has been unexpectedly found that the phosphated 2-propylheptanol or phosphated alkoxylated 2-propylheptanol where alkoxylate average includes 1-20, preferably 2-10, more preferably 2-6, more preferably 2-4, and most preferably 3 ethylenoxide link and 0-3, preferably 0-2 propylenoxide and/or butylaniline, preferably propylenoxide, link, is an effective hydrotap in alkaline aqueous solutions for alkoxylates C8-C18-, preferably C8-C12-alcohols containing 1-20, preferably 1-8, and most preferably 2-7, ethylenoxide links and 0-3, preferably 0-2, propylenoxide links, preferably to alkoxylated 2-propylheptanol according to the formula
<> where PO is propylenoxide group, EO represents ethyleneoxide group, a is a number 0-3, b is a number 1-8.
The invention also relates to aqueous cleaning solutions, including:
a) from 0.2 to 20%, preferably 2-10%, by weight of alkoxylate C8-C18-, preferably C8-C12-alcohol containing 1-20, preferably 1-8, and most preferably 2-7, ethyleneoxide units, preferably of alkoxylate 2-propylheptanol having the formula
where EO, PO, a, and b have the same meaning as described above;
b) 0.1 to 30, preferably 0.1 to 20, and most preferably 0.1 to 10% by weight of phosphated 2-propylheptanol and/or phosphated of alkoxylate 2-propylheptanol where alkoxylate average includes 1-20, preferably 2-10, more preferably 2-6, more preferably 2-4, and most preferably 3, ethylenoxide link and 0-3, preferably 0-2, propylenoxide link, preferably phosphated of alkoxylate according to the formula
where M represents H, a monovalent ion metal or R1R2R3R4N+where R1, R2, R3and R4represent H, an alkyl group with 1-4 carbon atoms or-CH2CH2OH, c represents the Wallpaper number 1-20, preferably 2-10, more preferably 2-6, more preferably 2-4, and most preferably 3, and
c) 0.05 to 40, preferably from 0.05 to 30, more preferably 0.05 to 20 and most preferably 0.05 to 15% by weight of alkali hydroxide and/or alkaline complexing agents; and they are homogeneous and stable upon dilution. The cleaning ability of these solutions is also very good.
Phosphated 2-propylheptanol or phosphated alkoxylated 2-propylheptanol can be obtained in various ways, the most common is the reaction of 2-propylheptanol or alkoxysilanes 2-propylheptanol with polyphosphoric acid or phosphorus pentoxide (P2O5).
In the method using polyphosphoric acid, the resulting mixture of products will mainly contain monocalciumphosphate ether 2-propylheptanol or alkoxysilanes 2-propylheptanol and only a small amount (<10%) dialkylphosphate ether. Always will be a fairly large amount of inorganic phosphate residues of polyphosphoric acid, such as orthophosphoric acid.
When the phosphate reagent is used P2O5and the molar ratio of P2O5and alcohol or alkoxycarbonyl alcohol is 1:3, the mixture of products will contain the AMB is approximately equal to the number monoalkylphenol ether and dialkylphosphate ether and only small amounts of inorganic phosphate residues. More alcohol or alkoxysilanes alcohol will give more diapir, and a smaller number will give more monoether. The person skilled in the art will know how to synthesize phosphate esters with certain quantities of mono - and dialkylphosphate esters. General description phosphate esters, see, for example, inAnionic SurfactantsVol. 7, Part II, pages 504-511 inSurfactant Science Series, edited by Warner M. Linfield, Marcel Dekker Inc., New York and Basel 1976. Alkoxylate spirits that need to be phosphotyrosine, can be any standard type, obtained using an alkaline catalyst such as KOH, or to treat type with a narrow distribution of molecular weight, obtained using catalyst narrow distribution, such as the acidic catalyst, Ca(OH)2or hydrotalcite.
Usually the reaction mixture obtained in both ways, before using neutralized organic or inorganic base. The base can be, for example, alkali hydroxide, such as sodium hydroxide or potassium hydroxide; ammonia, alkanolamine, such as monoethanolamine, triethanolamine or methyldiethanolamine; or alkylamine, such as triethylamine.
Monocalciumphosphate ether 2-propylheptanol or ethoxylated 2-propylheptanol has the formula
where M represents H, ion monovalent the metal or R 1R2R3R4N+where R1, R2, R3and R4represent H, an alkyl group with 1-4 carbon atoms or-CH2CH2OH, c represents a number of 0 to 20, preferably 2-10, more preferably 2-6, more preferably 2-4, and most preferably 3. The mixture of products obtained in the reaction of 2-propylheptanol or ethoxylated 2-propylheptanol with polyphosphoric acid, may also contain small amounts of products containing more than one phosphate level according to the formula
where n is 1-3 and M and c have the same significance as above.
In the case of ethoxylates containing smaller amounts ethylenoxide links, there is also a certain amount of methoxyethanol product due to this distribution ethylenoxide links. This methoxycarbonyl product will also propogation in the reaction with a phosphating agent and, therefore, the phosphate ester 2-propylheptanol will also be present in the reaction mixture resulting from the data above ethoxylates.
Dialkylphosphate ether 2-propylheptanol has the formula
where M and c have the same significance as above. The mixture of products obtained in the reaction of 2-propylheptanol or ethoxylated 2-is propylheptanol with P 2O5may also contain diphosphate ester according to the formula
where M and c have the same significance as above.
This type of diapir can hydrolyze with getting 2 moles of monoether.
2-Propylheptanol usually get way leading to small quantities of by-products such as 4-methyl-2-propylheptanol and 5-methyl-2-propylheptanol. These products or their ethoxylates also phosphatized during this process, and phosphate molecules will also be included in the resulting mixture of products.
The reaction mixture obtained by methods phosphating, usually used as such without any treatment, but as a mixture, and purified phosphate esters function as hydrotropes. In order to act as a good hydrotap, the mixture should preferably contain monocalciumphosphate esters, because they represent the best hydrotropic than dialkylphosphate esters. Preferably more than 60, more preferably more than 70, and most preferably more than 80% of the mixture should be monocalciumphosphate esters.
Phosphated 2-propylheptanol or phosphated alkoxylated 2-propylheptanol where alkoxylate average includes 1-20, preferably 2-10, more preferably 2-6, more preferably 2-4, and most is preferably 3, ethylenoxide link and 0-3, preferably 0-2, propylenoxide and/or butylaniline, preferably propylenoxide, link, described above, and methods for their production have been partially disclosed in the previously mentioned publications EP-A-256427 and CH-A-481953 for use as dispersing agents for pigments and as additives in the emulsion polymerization method, respectively. However, the phosphated alkoxylated 2-propylheptanol where alkoxylate average includes 2-4, preferably 3, ethylenoxide link, is particularly effective as hydrotap compared to other phosphated by alkoxylate 2-propylheptanol (see Table 1 in the Examples). Therefore, the invention also relates to alkoxylate phosphated 2-propylheptanol where alkoxylate average includes 2-4, preferably 3, ethylenoxide linkper seand by the way its receipt.
Alkoxylate C8-C18-alcohols can also 1-20 ethylenoxide links also contain 1-3 alkalinising link with 3-4 carbon atoms. Ethylenoxide links and propylenoxide and/or butylaniline links can be added randomly or in blocks. The blocks can be attached to alcohol in any order. Alkoxylate may also contain an alkyl group with 1-4 carbon atoms in the limit position. Preferably alkoxylate which contain 2-7 ethylenoxide links and 0-2 propylenoxide and/or butylaniline link.
Suitable alkoxylate, which can be used in cleaning compositions for cleaning hard surfaces, has the formula
where PO is propylenoxide group, EO represents ethyleneoxide group, a is a number 0-3, preferably 0-2, and b is a number from 1 to 8, preferably 2 to 7 and most preferably 3-6. When 2-propylheptanol contains the above-mentioned by-products, they will also be alkoxysilane and included in the resulting mixture of products. Cleaning concentrates obtained by use of phosphated alkoxylated 2-propylheptanol as hydrotropes for alkoxylated 2-propylheptanol are transparent and also stable upon dilution and cleaning compositions with these components show a good cleaning performance.
When the cleaning composition should be used for textile processing, such as washing, then alkoxylate a) should preferably include the number ethylenoxide links at the top of the range 1-20, for example 7-15 moles of EO per mole of C8-C18-alcohol.
Alkaline hydroxide in the composition is preferably a hydroxide of sodium or potassium. Alkaline complexing agents can be inorganic as well as organic. Tieckelmann inorganic complexing agents, used in alkaline compositions are silicate and phosphate alkali metal salts, such as sodium silicate, metasilicate sodium, sodium tripolyphosphate, sodium orthophosphate, sodium pyrophosphate and the corresponding potassium salts. Typical examples of organic complexing agents are aminophosphonate of alkali metals, organic phosphates, polycarboxylates, such as citrates; aminocarboxylate, such as nitrilotriacetate sodium (Na3NTA), sodium ethylenediaminetetraacetate (EDTA), diethylenetriaminepentaacetate sodium, 1,3-Propylenediamine sodium and hydroxyethylenediaminetriacetate sodium. The amount of alkali present in the composition depends on the application and on whether the composition is a concentrate or ready-to-use solution. In some applications, use of highly alkaline solutions, such as when Sharovka the concentration of alkali is about 4-6% by weight when using NaOH, and mercerized use approximately 20-26% by weight solution of caustic soda. The composition of the concentrate for cleaning vehicle typically contains from 6% to 15% by weight of alkali and/or alkaline complexing agents, and ready-to-use solution typically contains by weight from 0.2 to 5%. For washing, the amount of alkali and/or alkaline complexing agents less and Oba is but ranges from 3 to 10 mass% for the concentrate and 0.1-1% by mass in ready-to-use solution.
Concentrated compositions of the present invention are transparent and stable. The range of transparency seems to be acceptable in the temperature range between 0-40°C., preferably between 0-50°C. and most preferably between 0-60°C. It can be adjusted by changing the ratio of hydrotropes and nonionic surfactants. The concentrate typically contains 50-95% water by weight, more acceptable 70-90% by mass.
To obtain ready-to-use solution concentrates are diluted with water up to 1:40. Diluted solutions are also transparent and stable, but in some cases they can become somewhat murky, although they are still stable and not stratified. Ready-to-use solutions exhibit good cleaning properties. A typical formulation concentrate for cleaning the vehicle contains 3-5% by weight of a), 3-5% by weight of b) and 5-10% by weight of c), and ready-to-use recipe typically contains 0.2-1% by weight of a), 0.2 to 1% by weight of b) and 0.5-1% by weight of c).
The present invention is further illustrated by the following Examples.
Prepared formulations containing:
5% by weight of nonionic surfactants
10% by weight of Na3NTA (nitrilotriacetate sodium)
X% by weight of hydrotropes
Water to 100%
Hydrotap was added to this is Icesave, to the solution showed the range of transparency specified in Table 2. All interest - mass.
|Coconut fatty amine+17EO, quaternionic with CH3Cltd align="left">||3%|
22-PG+3EO=2-propylheptanol, ethoxylated with 3 moles of ethylene oxide
32-PG+5EO=2-propylheptanol, ethoxylated with 5 moles of ethylene oxide
To assess the effectiveness of cleaning formulations from Table 1 used the following test to clean: White painted plate smeared with a mixture of oily soot obtained from a diesel engine. 25 ml of the test solution, in this case prepared by diluting 1:20 formulations from Table 1, was poured on the surface of greased plates and left them in for one minute. Then the plates were washed with mobilnisvet.com water. For all solutions and water maintained a temperature of 15-20°C. All solutions comparison was placed on the same plate as the test solutions. The cleaning ability was measured with reflectometer Minolta Chroma Meter CR-200, the result is presented as % remove dirt. The results are shown in Table 2.
|Recipe №||The range of transparency (°C)||Appearance after dilution 1:20||Remove dirt when diluted 1:20 (%)|
|I||0-50||Cloudy but stable||77,5|
|V||0-75||Cloudy but stable||71,5|
Formulations containing phosphated 2-propylheptanol or phosphated ethoxylates of 2-propylheptanol as hydrotropes showed better cleaning characteristics than the recipe comparison, containing coconut fatty amine + 17 EO, quaternionic with CH3Cl. The two values for connection of the comparison, since the cleaning efficiency was tested on two separate plates; one with I, II, III and IV, and the other with V, VI, VII and IV.
This example relates to the comparison between the phosphated 2-propylheptanol+5EO and phosphated by geksanalem+5EO as hydrotropes 2-propylheptanol+5EO.
|Connection||Recipe A||Formulation B (Comparison)|
|Recipe||The range of transparency (°C)||Appearance after dilution 1:1||Appearance after diluting 1:5||Appearance after resbala of 1:10||Appearance after resbala of 1:20||Remove dirt with razbam of 1:20 (%)|
|A||0-60||Transparent||Transparent||Cloudy but stable||Cloudy but stable||68,5|
To obtain a range of transparency 0-60°With fewer phosphated 2-propylheptanol+5EO compared with the phosphated geksanalem+5EO.
Recipes with phosphated 2-propylheptanol+5EO as hydrotropes showed approximately the same cleaning efficiency as the recipe with the phosphated geksanalem+5EO, but the former were much more stable when diluted than the last.
This example compares the number of phosphated ethoxylated alcohols with phosphated 2-propylheptanol+5EO as hydrotropes 2-propylheptanol+5EO.
|Connection||1||2 (Cf. the ranking)||3 (Comparison)||4 (Comparison)|
|Recipe||The range of transparency (°C)||Appearance after diluting 1:5 through 1 day||Appearance after resbala of 1:20 through 1 day||Appearance after resbala of 1:5 after 1 week||Appearance after dilution 1:20 through 1 week||Remove dirt with razbam of 1:20 (%)|
|1||0-70||Transparent||Transparent||Transparent||Cloudy but stable||60,0|
From all investigated formulations better cleaning characteristics in combination with good stability upon dilution showed the formulation according to the invention.
Table 7 shows the recipe, where the same number of hydrotropes was added to all formulations. The cleaning efficiency of various formulations are shown in Table 8.
|Connection||5||6||7 (EUR.)||8 (EUR.)||9 (EUR.)|
|Recipe||The range is transparent-ness (°C)||Appearance after diluting 1:5 in 4 days||Appearance after dilution 1:20 in 4 days||Remove dirt when diluted 1:30 (%)||Remove dirt when diluted 1:40 (%)|
Formulations according to the invention are more efficient than the recipe comparison.
In this example, phosphated 2-propylheptanol+5EO added as hydrotropes to a number of nonionic surfactants and tested recipes for their cleaning efficiency.
|Recipe||The range of transparency (°C)||Appearance after dilution 1:20 in 1 month||Remove dirt when diluted 1:20 (%)|
|13||0-50||Slightly cloudy but stable||76,0|
The data show that the phosphated 2-propylheptanol+5EO also serves as hydrotropes for nonionic compounds other than ethoxylates of 2-propylheptanol, and that the cleaning efficiency of these formulations generally good.
In this example, the wetting ability of the composition according to the invention was measured using a modified test Drava.
|Recipe||The range of transparency (°C)||pH||The settling time|
Formulation containing phosphated 2-propylheptanol+5EO as hydrotropes for ethoxylate, had a good wetting ability, whereas for the various components, taken separately, the time of wetting was > 420 S. C9-C11-Alcohol insoluble in this alkaline environment in the absence of hydrotropes and phosphated 2-propylheptanol+5EO itself does not have good wetting ability. When you add hydrotap, nonionic surfactant solubilizated, and in that the om case, it can show its wetting ability.
In the syntheses described below, used a flask with flange connection, equipped with an anchor stirrer. The reactor was heated using an electric heater, thermostatically controlled. During the reaction gave a weak stream of nitrogen. Used polyphosphoric acid (PFC) was a polyphosphoric acid 116 equivalent to P2O5equal to 84% (Albright &Wilson).
1) 2-propylheptanol + PFC
2-propylheptanol (222,47 g of 1.41 mol) was placed in a flask and heated to 45°C. PFC (254,09 g) was added from a syringe to the 60 ml and supported exothermic reaction at 55-70°C under stirring to 240 rpm PFC) was added within 1 hour. Then the reaction was left for 2 hours at 60°C and stirring at 300 rpm Then added post-reaction water (5.0 g) for hydrolysis of the remaining PFC, after which the acid was neutralized with KOH (274,4 g)dissolved in 555,0 g of water.
2) 2-propylheptanol + 3 EO + PFC
2-propylheptanol + 3 EO (295,63 g of 1.02 mol) were placed in a flask and heated to 45°C. PFC (184,95 g) was added from a syringe to the 60 ml and supported exothermic reaction at 55-70°C under stirring to 240 rpm PFC) was added within 1 hour. Then the reaction was left for 2 hours at 60°C and stirring at 300 rpm Then added post-reaction water (5.0 g) for hydrolysis of the remaining PFC, after which the acid was neutralized with KOH (191 g)dissolved in 454 g of water.>
3) 2-propylheptanol + 5 EO + PFC
2-propylheptanol + 5 EO (307,71 g, 0.81 mol) was placed in a flask and heated to 45°C. PFC (148 g) was added from a syringe to the 60 ml and supported exothermic reaction at 55-70°C under stirring to 240 rpm PFC) was added within 1 hour. Then the reaction was left for 2 hours at 60°C and stirring at 300 rpm Then added post-reaction water (5.0 g) for hydrolysis of the remaining PFC, then 374,02 g of acid was neutralized with KOH (132,37 g)dissolved in 517 g of water.
1. The use of phosphated 2-propylheptanol or phosphated of alkoxylated 2-propylheptanol including 1-3 phosphoric acid residue, where alkoxylate portion contains from 1 to 20 ethylenoxide links and 0-3 propylenoxide and/or butylaniline link that represents the esters of phosphoric or polyphosphoric acids or their salts with monovalent ion metal or R1R2R3R4N+where R1-R4represent H, C1-4-alkyl or-CH2CH2IT, including mixtures resulting from the interaction of 2-propylheptanol, of ethylene oxide and polyphosphoric acid, as hydrotropes for alkoxylate8-C18-alcohol containing 1-20 ethylenoxide links and 0-3 propylenoxide and/or butylaniline link, in an alkaline aqueous solution.
2. The use according to claim 1, where alkoxylate C8
-C18-alcohol has the formula
where RO represents propylenoxide group, EO represents ethyleneoxide group, and is a number 0-3, b is a number 1-8.
3. The use according to claim 1 or 2, where phosphated 2-propylheptanol or phosphated alkoxylated 2-propylheptanol has the formula
where M represents H, a monovalent ion metal or R1R2R3R4N+where R1, R2, R3and R4represent H, an alkyl group with 1-4 carbon atoms or
-CH2CH2HE represents a number of 0 to 20.
4. The use according to claim 1 or 2, where the phosphated alkoxylated present in mixtures containing two or more of the following components:
compounds of the formula II:
where M represents H, a monovalent ion metal or R1R2R3R4N+where R1, R2, R3and R4represent H, an alkyl group with 1-4 carbon atoms or
-CH2CH2HE represents a number of 0 to 20;
compounds of the formula
where n is 1-3 and M and C have the same meaning as described above
compounds of the formula
where M and C are zaznaczenie, as indicated above, and
compounds of the formula
where M and C have the same meaning as described above
and where II is present in amount of at least 60 wt.% by weight of the mixture.
5. Phosphated alkoxylated 2-propylheptanol, alkoxylate part of which consists of 2-4 ethylenoxide links, including 1-3 phosphoric acid residue constituting the esters of phosphoric or polyphosphoric acids or their salts with ions of monovalent metal or R1R2R3R4N+where R1-R4represent H, C1-4-alkyl or-CH2CH2OH, including mixtures resulting from the interaction of 2-propylheptanol, of ethylene oxide and polyphosphoric acid.
6. Phosphated alkoxylate according to claim 5, comprising one or more products with formulas
where M represents H, a monovalent ion metal or R1R2R3R4N+where R1, R2, R3and R4represent H, an alkyl group with 1-4 carbon atoms or
-CH2CH2HE and represents the number of 2-4,
where n is 1-3 and M and C have the same meaning as described above
where M and C have the same meaning indicated above, and
where M and C have the same meaning as specified above.
7. A cleaning composition that includes
a) from 0.2 to 20% by weight of alkoxylate C8-C18-alcohol containing 1-20 ethylenoxide link,
b) 0.1 to 30% by weight of phosphated 2-propylheptanol and/or phosphated of alkoxylate 2-propylheptanol described in claim 1, and
C) 0.05 to 40% by weight of alkali hydroxide and/or alkaline complexing agents, where the alkaline hydroxide include sodium hydroxide and potassium, and alkaline complexing agents may be inorganic, including silicate and phosphate alkali metal salts, sodium silicate, metasilicate sodium, sodium tripolyphosphate, sodium orthophosphate, sodium pyrophosphate and the corresponding potassium salts, or organic, including aminophosphonate of alkali metals, organic phosphates, polycarboxylates, citrates, aminocarboxylate, nitrilotriacetate sodium (Na3NTA), sodium ethylenediaminetetraacetate (EDTA), diethylenetriaminepentaacetate sodium, 1,3-Propylenediamine sodium and hydroxyethylenediaminetriacetate sodium.
8. The composition according to claim 7, where (a) represents alkoxylate alcohol, including 2-7 ethylenoxide links, and (b) represents the phosphated alkoxylated 2-propylheptanol, including 2-4 ethylenoxide link.
9. The composition according to claim 7 or 8, wherein b) comprises phosphated 2-propelled anal and/or one or more of phosphated alkoxylated 2-propylheptanol, having the formulas II, III, IV and/or V is defined as described in claim 4, and where II is present in amount of at least 80 wt.% by weight of the mixture.
10. The composition according to claim 7 or 8, where (a) represents alkoxylate 2-propylheptanol according to the formula (I), determined as specified in claim 2, in which a is 0 and b is on average 3-6.
11. The use of a composition according to any one of claims 7 to 10 for industrial cleaning hard surfaces.
12. The application of item 11 to clean vehicles or in the dishwasher.
SUBSTANCE: detergent composition has pH ranging from neutral to alkaline and contains an aqueous solution. The solution contains 0.005-10% surfactant with low foaming capacity; 0.005-10% corrosion inhibiting compound selected from C4-C16 alkylpyrrolidones and C1-C18 alkylamines and 0.01-15% modifying additive for preventing precipitation when metal ions react with the said surfactant. The cleaning solution contains a corrosion inhibitor and leaves a small amount of residue. The compositions are used not only at the washing stage of the cleaning cycle, but at one of the subsequent stages of the rinsing cycle in order to optimise cleaning and prevent rusting.
EFFECT: improved anti-corrosion and cleaning properties.
14 cl, 3 tbl
SUBSTANCE: proposed washing agent contains the following, in g/l: sodium hydroxide - 1.16-6.38, sodium silicate - 0.01-0.70, tri-sodium phosphate - 0.016-0.09, complexon - 0.0095-0.05, mixture of non-ionogenic surfactants of the Berol DGR81 type - 0.078-0.428 and the rest is water, with mass ratio of mixture of sodium hydroxide and complexon to the mixture of non-ionogenic surfactants equal to 15:1.
EFFECT: washing agent provides for high detergent power and has low foaming.
1 cl, 2 tbl, 6 ex
SUBSTANCE: detergent contains the components as follows, wt %: anionic surface active agent (SAG) - alkylbenzol sodium sulphonate 10-16; nonionic SAG - oxyethylated fatty alcohols or oxyethylated alkylphenol 2-5; sodium tripolyphosphate 15-25; organophosphonate compound - sodium salt 1-hydroxyethylidene of phosphonic acid or sodium diethylentriaminopentaxys-(methylene phosphonate) 0.2-0.6; polycarboxylate 0.5-1.5; carboxymethyl cellulose 0.3-0.6; modified polyalkylene glycol 0.2-0.6; optical bleaching agent 0.05-0.3; soda ash 3-6; liquid glass 3.5-6.0; enzyme 0.4-0.7; defoaming agent 0.05-1.5; aromatiser 0.15-0.3; sodium sulphate and water to 100.
EFFECT: higher efficiency of bleaching detergent, all type decontamination with additional softening of fabric and without irritation of hand skin during manual washing, lower temperature modes of washing, reduced damage effect on metal parts of washing machines.
10 cl, 2 tbl, 5 ex
SUBSTANCE: invention is used in metallurgy industry for degreasing rolled metal products on the aggregates of continuous processing before application of different kinds of coatings (zinc, galvalume and etc.). The agent contains in g/l: sodium hydroxide 5.4-12.0, sodium carbonate 3.3-8.2, trisodium phosphate 0.6-1.25, sodium tripolyphosphate 1.0-2.5, hyrdroxyethylated alkylphenol on the basis of propylene trimer containing in a molecule 12 moles of ethylene epoxide 0.17-0.37, polyethyleneglycol esters of synthetic primary alcohol of C12-C14 fraction 0.14-0.23, alkylphenilpolyoxyethelenglycol acetal 0.11-0.28, chelate 0.02-0.075, defoaming agent 0.001-0.0025, water - 1 liter. Mass ratio of the blend of the organic and inorganic part of the composition to the blend of surfactants is 24.5:1. Chelate consists of disodium salt of tetrine, hydrous and trisodium salt of hydroxyetheledenediphosphonic.
EFFECT: increase of purification degree of metallic surface thanks to high cleaning capability of the composition and foam forming decrease.
SUBSTANCE: present invention concerns lysine compounds of formula (I) or its pharmaceutically acceptable salts, a based pharmaceutical compositions and application for treatment or prevention of HIV-infection. The compounds of formula (I) where n is equal to 3 or 4, where X and Y identical or different are chosen from the group consisting of H, F, Cl, Br, I and -NR4R5, where R6 is chosen from the group consisting of unbranched alkyl group, containing 1 to 6 carbon atoms, and branched alkyl group containing 3 to 6 carbon atoms, where R3 is chosen from the group consisting of the group of formula R3A-CO-, and R3a is chosen from the group consisting of unbranched or branched alkyl group containing 1 to 6 carbon atoms, alkyloxygroup containing 1 to 6 carbon atoms, and 4-morpholinyl, where R4 and R5 are identical and represent H, where R2 is chosen from the group consisting of diphenylmethyl group, naphthyl-1-CH2-group, and naphthyl-2-CH2-group, where X' and Y' are identical and represent H, and where R1 is chosen from the group consisting of from (HO)2P(O) and (MO)2P(O), where M represents alkaline metal.
EFFECT: lysine compounds representing effective inhibitors of aspartyl-protease.
15 cl, 3 tbl, 1 ex
SUBSTANCE: present invention relates to a compound of formula I , where X is C; W is N; V is C; R1 is hydrogen, methoxy or halogen; R2 is absent; R3 is methoxy or heteroaryl, each of which can be optionally independently substituted with one substitute, selected from G; where heteroaryl is triazolyl or pyrazolyl; E is hydrogen or its pharmaceutically acceptable mono or bis salt; Y is selected from a group which consists of and R10, R11, R12, R13, R14, R15, R16, R17 each independently represents H or methyl, under the condition that, not more than two of R10-R17 is methyl; R18 is selected from a group which consists of C(O)-phenyl and quinazolinyl; D is cyano; A is pyridinyl; G is (C1-6)alkyl. The invention also relates to methods of producing compounds of formula I.
EFFECT: obtaining new compounds with antiviral activity.
15 cl, 23 dwg, 48 tbl, 16 ex
SUBSTANCE: invention relates to new phosphates of nitrophenylpyrite and nitrophenylaziridine alcohols of general formula , where: X represents -CONH- in any accessible position of the ring; R is a lower C1-6alkyl; Y represents -N-aziridinyl in any accessible position of the ring, -N(CH2CH2W)2 or -N(CH2CHMeW)2, where W is independently chosen from halogen or -OSO2Me; Z represents NO2 or -SO2Me in any accessible position of the ring; and its pharmaceutically acceptable salts. The invention also pertains to a method of producing phosphates of formula (I) and formulae , and (particular cases of formula (I)), a method of anticancer treatment and a method of destroying hypoxic cells using formula (I) compounds, as well as to a pharmaceutical composition based on formula (I) compounds.
EFFECT: obtaining new compounds which can be used as targeted cytotoxic agents.
14 cl, 5 tbl, 4 dwg, 39 ex
SUBSTANCE: agricultural finished form of composition contains at least one agricultural active ingredient and at least one agricultural adjuvant or auxiliary agent. Adjuvant includes at leasdt one phosphatised 2-propyl heptanol, phosphatised alkoxylate of 2-propyl heptanol or their mixture. Composition contains 0.1-30% of weight of adjuvant. Alkoxylate includes in average 1-20 ethyleneoxy units and 0-3 propyleneoxy and/or butyleneoxy units. Method of plant processing includes contacting of plants with agriculturally efficient quantity of agricultural finished form.
EFFECT: invention allows to increase stability and activity of composition.
15 cl, 8 tbl, 1 dwg
SUBSTANCE: invention relates to a method of producing polymer material, enriched with phosphorus, which is used as a fireproof additive. A method is described for producing fireproof polymer material in two stages by reacting initial reagents in a reactor. The first stage involves reacting anhydrous phosphorous pentoxide with a second reagent, chosen from a group consisting of (a) diol, which is 1,3-propanediol and 1,4-butanediol, and (b) a mixture of cyclic ether and alcohol, obtaining polymer precursor material. The second stage involves reacting polymer precursor material with cyclic ether, for example ethylene oxide, propylene oxide and/or glycidol, obtaining the final product. Described also is a fireproof composition, which contains polymer material in form of a salt, obtained by reacting phosphoric ester with an amine, chosen from melamine and polyethylenimine.
EFFECT: obtaining water-insoluble intumescent polymer material which promotes reduction of flammability.
47 cl, 3 dwg, 5 tbl, 13 ex
SUBSTANCE: mixture of monoalkyldiphenylphosphates and dialkylmonophenylphosphates is obtained from reacting phosphorous oxychloride with phenol, after which dichloromonophenylphosphate and monochlorodiphenylphosphate are reacted with aliphatic alcohol in the presence of catalyst - Lewis acid in the absence of a solvent at temperature 60-200°C and pressure from 0.001 to 1.1 bar abs.
EFFECT: design of a new method of producing alkylphenylphosphates and their mixtures, suitable for use plasticisers, lubricants and fireproofing compositions.
16 cl, 17 ex, 5 tbl
SUBSTANCE: scope of invention covers production of complexes of Sn or Ti chlorides or of Si phenyltrichloride with common formula 2(RO)3P=O·ER1Cl3, where E = Sn, Ti or Si; R = -CH2CH2Cl, -CH2CH(Cl)CH3, -CH2CH(Br)CH2(Br); R1=Cl or -C6H5, suitable for use as catalysts in organic synthesis. The method includes interaction of tris(halogenalkyl)phosphates with Sn or Ti tetrachlorides or Si phenyltrichloride at ambient temperature and mole ratio phosphate: chloride 2 : 1.
EFFECT: production of new complexes of chlorides with orto-phosphate acid esters.
5 ex, 2 tbl
FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to a new method for synthesis of water-soluble formulations of pharmaceutical preparations containing a blocked aromatic hydroxyl group. Invention describes a method for synthesis of water-soluble phosphonooxymethyl derivatives involving the following steps: step (1): wherein R-OH is converted to R-O-CH2Cl, and step (2): wherein compounds synthesized in the first step is used and wherein R-O-CH2Cl reacts with the phosphoric acid molar excess and a base in suitable polar aprotonic solvent, and wherein R-OH represents a drug containing alcohol or phenol; n = 1 or 2; R1 means hydrogen atom, alkaline metal ion or pharmaceutically acceptable cation; R2 means hydrogen atom, alkaline metal ion or pharmaceutically acceptable cation. Also, Invention describes a method for synthesis of water-soluble phosphonooxymethyl-propofol. Invention provides simplifying the process for synthesis of water-soluble formulations of pharmaceutical preparations.
EFFECT: improved method of synthesis.
26 cl, 4 ex
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel soluble pharmaceutical salts formed from salt-forming active compound of the general formula (I) or (II) and sugar substitute that can be used in preparing medicinal agents useful in pain and enuresis treatment. Salt-forming active substance represents a salt-forming compound among 1-phenyl-3-dimethylaminopropane compounds of the general formula (I) wherein X means -OH, F, Cl, H or group -OCOR6; R1 represents (C1-C4)-alkyl group; R2 represents H or (C1-C4)-alkyl group; R3 represents H or (C1-C4)-alkyl group with a direct chain, or R2 and R3 form in common (C4-C7)-cycloalkyl group and if R5 means H then R4 represents group O-Z in meta-position wherein Z means H,(C1-C3)-alkyl, -PO-(O-C1-C4-alkyl)2, -CO-(O-C1-C5-alkyl), -CONH-C6H4-(C1-C3-alkyl), -CO-C6H4-R7 wherein R7 represents -OCO-C1-C3-alkyl in ortho-position or group -CH2N(R8)2 in meta- or para-position and wherein R8 means (C1-C4)-alkyl or 4-morpholino-group, either R4 represents S-(C1-C3)-alkyl in meta-position, meta-Cl, meta-F, group -CR9R10R11 in meta-position wherein R9, R10 and R11 mean H or F, group -OH in ortho-position, O-(C2-C3)-alkyl in ortho-position, para-F or group -CR9R10R11 in para-position wherein R9, R10 and R11 mean H or F, or if R5 means Cl, F, group -OH or O-C1-C3-alkyl in para-position then R4 means Cl, F, group -OH or O-(C1-C3)-alkyl in meta-position, or R4 and R5 form in common group 3,4-OCH=CH- or OCH=CHO-; R6 means (C1-C3)-alkyl, or salt-forming active substance represents a salt-forming compound among 6-dimethylaminomethyl-1-phenylcyclohexane compounds of the general formula (II) wherein R1' represents H, -OH, Cl or F; R2' and R3' have similar or different values and represent H, (C1-C4)-alkyl, benzyl, -CF3, -OH, -OCH2-C6H5, O-(C1-C4)-alkyl, Cl or F under condition that at least one among radicals R2' either R3' means H; R4' represents H, -CH3, -PO-(O-C1-C4-alkyl)2, -CO-(O-C1-C5-alkyl, -CO-NH-C6H4-(C1-C3)-alkyl, -CO-C6H4-R5', CO-(C1-C5)-alkyl), -CO-CHR6'-NHR7' or unsubstituted either substituted pyridyl, thienyl, thiazolyl or phenyl group; R5' represents -OC(O)-(C1-C3)-alkyl in ortho-position or -CH2N(R8')2 in meta- or para-position and wherein R8' means (C1-C4)-alkyl, or both radicals R8' in common with nitrogen atom (N) form 4-morpholino-group, and R6' and R7' have similar or different values and represent H or (C1-C6)-alkyl under condition that if both radicals R2' and R3' represent H then R4' doesn't mean -CH3 when R1' represents additionally H, -OH or Cl, either R4' doesn't mean H when R1' represents additionally -OH. Also, invention relates to a medicinal agent based on indicated salts.
EFFECT: valuable medicinal properties of salts and drug.
14 cl, 1 tbl, 8 ex
FIELD: chemistry of organophosphorus compounds.
SUBSTANCE: invention relates to the improved method for synthesis phosphorus-chlorine-containing methacrylates that can be used in synthesis of polymeric, among them, uncolored, optically transparent and composition materials with reduced inflammability. Invention describes a method for synthesis of phosphorus-chlorine-containing methacrylates of the general formula:
wherein R means lower alkyl, chloroalkyl, alkoxyl, phenoxyl or group of the formula:
R1 means lower alkoxyl, phenoxyl or group of the formula:
Method involves interaction of phosphoric pentavalent acid chloroanhydrides with methacrylic acid glycidyl ester at heating in the presence of hexamethylenephosphorotriamide or dimethylformamide as a catalyst wherein catalyst is taken in the amount 0.3-0.6% of reagents mass, and process is carried out at rise of temperature from 40°C to 80°C in the presence of compound chosen from the group: alkyl- or alkoxy-substituted phenols taken in the amount 0.03-0.3% of reagents mass. Method provides decreasing water absorption of (co)polymerization products of synthesized phosphorus-chlorine-containing methacrylates and reducing retention time of surface stickiness of fiber glass synthesized on their basis and at retention the level of other properties, among them transparence and colorless.
EFFECT: improved method of synthesis, improved and valuable properties of compounds.
2 tbl, 10 ex
FIELD: coordination compounds synthesis.
SUBSTANCE: invention provides complex comprising calcium and [[(4R)-4[bis[carboxy.kappa.O)methyl]amino-.kappa.N]-6,9-bis[carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecane-11-ylic acid-.kappa.N6,.kappa.N9,-kappa.011]-oxydato(6-)]-,6H, (MS-325) or its salt with physiologically acceptable cation in each case containing essentially no Gf-MS-325. Also described are pharmaceutical agent based on compounds according to claim 1 and a method for preparing galena composition, complex or its salt with physiologically acceptable cation according to claim 1 intended for preparation of pharmaceutical agent reducing effect produced by heavy metals as well as complex or its salt with physiologically acceptable cation according to claim 1 intended for preparation of pharmaceutical agent suitable for NMR diagnostics and/or diagnostic radiology, a method for amplifying patient's image in NMR tomography based on compounds according to claim 1 and above defined complex or its salt with physiologically acceptable cation in each case containing essentially no visualizing metal chelates and MS-325.
EFFECT: increased assortment of complexes with useful medicine-destination properties.
14 cl, 4 dwg, 30 ex