Method of nanostructurisation of bulk bio-compatible materials

FIELD: nanotechnologies.

SUBSTANCE: invention relates to laser equipment used for the purposes of nanotechnologies, particularly, to the methods of nanostructurisation of bulk bio-compatible nanomaterials by laser radiation. Nanostructurisation of the aforesaid materials is performed by laser irradiation of colloidal water-protein solution of carbon nanotubes till evaporation of the solution liquid component.

EFFECT: varying the properties of produced materials in a wide range and remote irradiation provides for biological purity of products.

3 dwg

 

The invention relates to the field of laser technology used in nanotechnological purposes, and in particular to methods of nanostructuring of bulk biocompatible nanomaterials under the action of laser radiation.

One of the important tasks of modern nanotechnology is the creation of artificial surgical implants of human organs. Commonly used for these purposes, endo - and ectoprocta short supply and expensive; metal implants must be replaced after a short operation by operating, causing pain and discomfort of patients; plastic implants are not strong enough and short-lived.

However, there is a fundamental possibility of solving these problems using the implants of the filling of nanomaterials, in particular, of compositions based on carbon nanotubes. As follows from the data [1, 2], carbon nanotubes can grow and develop nerve and bone cells. This opens up the path of self-Assembly of biological tissues at high strength nanotubes frame.

Known two-dimensional nanotrubki design, performed to the orientation of quartz and other substrates [3]. However, a prerequisite of the use of nanomaterials to fill the implants is their production in the form of bulk compositions is s.

There is a method of laser irradiation for forming the convex structures on the surface of polymeric materials (effect of laser swelling) [4]. However, in this case there are only the surface of the nanostructure, of a height of 0.1 μm when the diameter of about 0.2 μm, and the material is not biocompatible.

Closest to the proposed invention relates to the method of application of UV excimer laser to obtain anonymously beam structures on various materials. Such structures are, in particular, to create a neurosurgical microimplants for stimulation of neural tissues [5]. However, in this case we are talking only about the surface nanostructure height of not more than 0.08 μm.

The present invention is to nanostructuring of bulk biocompatible nanomaterial under the action of laser radiation.

The method of nanostructuring of bulk biocompatible materials include laser irradiation of colloidal aqueous protein solution of carbon nanotubes until the evaporation of the liquid component of the solution.

The essence of the invention lies in the fact that thermal action of laser radiation allows to vaporize the liquid component of the solution and to obtain after evaporation of the liquid homogeneous composite nanomaterial cher the CSOs color, represents an ordered structure of aggregates of CNTS modified albumin.

Figure 1 shows a photograph of a glass vessel with nanomaterial obtained after evaporation of the liquid components of the colloidal aqueous protein solution of carbon nanotubes.

Figure 2 shows the measurement data of the film characteristics of the nanomaterial on a silicon substrate obtained by using a scanning probe microscope. On figa shows a diagram of the photodiode current, receiving the signal from the cantilever, which varies over the scanned surface. Figb demonstrates the character of the topography of the object in a similar scanning of the cantilever, the bright area was a hill, the dark region is deepening.

As can be seen from FIGU, the nanomaterial is a volumetric quasiperiodic composition round or toroidal globules with a diameter equal to 200-500 nm, and the visible height of 30-40 nm. The analysis charts the photodiode current indicates the electric charge of the material of the globules, which are rolled in a tangle of carbon nanotubes and their separating layer - modified albumin.

Figure 3 shows a method of laser irradiation of colloidal aqueous protein solution of carbon nanotubes. Figa shows the location of the vessel with the solution relative to the origin of the radiation is con - diode laser with optical output (λ=0,97 μm, N≤10 W), equipped with a light pointer. On figs shows the vessel with the solution, osveschennaja designator (green emission).

An important advantage of laser nanostructuring is distanced action that eliminates insertion of pollution and to ensure the biological purity of a nanoproduct.

The composition of the composite, consisting of a biocompatible component, and provides the biocompatibility of the obtained product, which can be used as a fill material for surgical implants.

The advantage of nanomaterial obtained after evaporation of the liquid components comprising the solution is also possible to vary the consistency of the nanomaterial from the glass - to pasty depending on the intensity and duration of laser irradiation. Glassy nanomaterial convenient for immediate use in the composition of the surgical implant. Pasty nanomaterial convenient for its application operated on the surface of the biological tissue with subsequent laser welding it with a cloth.

One promising area of application of the paste-like nanomaterial is the treatment of congenital malformations (CDF) of a person. One of the most dissemination is anenih species CDF are malformations of the maxillofacial area, 90% of them are congenital clefts of the upper lip and/or palate. The problem of treatment VLOOKUP particularly urgent against the background of trends, on the one hand, to the decrease in total fertility and, on the other hand, to increase the number of children with VLOOKUP, which is 1-12% of all newborns.

The practical applicability of the proposed method of nanostructuring of bulk biocompatible nanomaterial is illustrated in the following stages of manufacture and the results of investigation of the nanostructure of the material.

1. Stage 1. In distilled water dissolve albumin in a concentration of from 10 to 50% and then the solution was dispersed in an ultrasonic bath at a temperature of 40-50°until a homogeneous colloidal solution of albumin, usually within 1-2 hours.

2. Stage 2. In the solution from step 1 enter the carbon nanotubes at a concentration of 1-5 g/l and then, the solution was placed in an ultrasonic bath and dispersed within 3-5 hours to obtain a homogeneous colloidal aqueous protein solution of carbon nanotubes black.

3. Stage 3. The solution from stage 2 is poured into a glass vessel and irradiated with laser light for 10-30 min until complete evaporation of the liquid components of the solution and a homogeneous composite nanomaterial black.

Sources of information

1. US Patent No.6.670.179.

2. Cancers EG Nanatsu the key and fullerenes. // M: University book, Logo, 2006

3. L..Zanello, B.Zhao, NNi, R..Haddon. - Nano Letters, 2006, v.6, n.

4. Ajomale, Nimbidin. - Izv. Higher education INSTITUTIONS. Instrumentation, 2006, v.49, No. 9, p.9.

5. US Patent No.6.853.075.

The method of nanostructuring of bulk material, characterized in that conduct laser irradiation of colloidal aqueous solution of albumin containing carbon nanotubes, until evaporation of the liquid component of the solution.



 

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