Method for regulating physiologic condition of biological object with gas mixtures

FIELD: medicine.

SUBSTANCE: method involves treating biological object placed in medium containing at least one gas, with gas mixture containing oxygen as one of its ingredients. The treatment is carried out during at least one procedure in cyclic mode keeping given pattern providing saturation and/or desaturation of at least one gas mixture ingredient in biological object tissue cells according to given algorithm. The number of procedures and their periodicity are selected depending on the number of saturated and/or desaturated gases and their saturation and/or desaturation degree.

EFFECT: activated oxidation-reduction and energetic processes.

21 cl

 

The technical field

The invention relates to medicine and medical technology and is intended for use as a means for regulation of the physiological condition of a biological object, in particular increasing its adaptation to changes in the environment, but also as a means for the treatment of bronchopulmonary, cardiovascular and other diseases, including chronic nature, first aid, for example, when hypothermia, respiratory failure, anesthesia, rehabilitation facilities in the postoperative period to prevent postoperative pneumonia, etc., withdrawal syndrome, drug dependence, and in some other cases, to increase the overall resistance of the organism.

Prior art

Recent advances in the field of brotizolam and diving medicine show that in the development of new means and methods of artificial respiration gas mixtures appeared purposeful physiological effects on the biological object, mixtures of gases, including oxygen. In addition to oxygen also introduce inert gases, especially helium and argon, and nitrogen, hydrogen, krypton, xenon in various concentrations and compositions.

Of particular interest in this regard is helium. His physical SV is istwa (density nearly 7 times smaller, than nitrogen, the main the diluent gas of oxygen, conductivity 5, 8 times, and higher and a solubility in fats 4, 5 times and less than that of nitrogen at normal pressure) ensure breathing physiological effects differ from the effects of air breathing mixtures, namely the reduction of energy consumption of the respiratory muscles, improved oxygen diffusion, etc.

These effects are used not only when carrying out deep-sea diving descents, but also in the treatment of several diseases of the respiratory and cardiovascular systems during inhalation anesthesia and in the postoperative rehabilitation (Hess D.R., R.H. Acosta The effect of heliox on nebulizer function usinga beta-agonist bronchodilator. Hest 1999, 115 (1):184-189).

A mixture of oxygen and inert gases (helium, argon, neon, krypton, xenon) exhibit physiological activity. First of all physiological activity unrelated to the oxygen gas is manifested in their narcotic effect. So, xenon and krypton mixed with oxygen already at normal pressure cause anesthesia, similar to the action of anesthetics used in medicine in anesthesia.

The narcotic properties of argon begin to appear at a pressure of 2 kgf/cm2and nitrogen at high pressure 6 kgf/cm2. This action of nitrogen are well studied in the case of diving, and the condition of man when it is called "nitrogen narcosis". Hydrogen in breathing mixtures shows the narcotic properties at pressures higher than 20 kgf/cm2. The neon and helium under pressure meaningful drug is not detected (N.V. Lazarev Biological action of gases under pressure, L., ed. Military med. Acad., 1941, s.219; Zaltsman GL, Kucuk GA, Gurgenidze A.G. fundamentals of hyperbaric physiology. L., Medicine, s, 1970; Smolin CENTURIES, Rapoport K.M., Kucuk G.A. Materials on narcotic effect of the increased pressures of nitrogen, argon and helium on the human body; kN. "Human and animal physiology". - M., 1974. T; Bennett W., Rostain J.C. The high pressure nervous syndrom, Phisiol., and med. Of diving, 4th ed.,1993, p.195-237).

When studying the effect of argon at normal pressure for a period of hypoxia found that argon increases resistance of the organism of humans and mammals to hypoxia compared with nitrogen in the same oxygen content of gas mixtures (Art. Kulagina Y.A., A.I. Dyachenko, BORIS Pavlov. Gas exchange in humans during exercise using breathing hypoxic CAS and KAAPC., Sat. reports. Moscow, "Indifferent gases in diving practice, biology and medicine". Ed. Word 2000, s-214).

It is also known the use of helium for the treatment bronchoobstructive diseases such as bronchial asthma, etc. (Barach A.R., Science 1934, 80:593; Troshin CENTURY the Body of helices orodno environment. Leningrad, Nauka, 1989, s).

There is a method of regulation of the physiological condition of a biological object by mixtures of gases through effects on the biological object, placed in a gas medium, at least two-component gas mixture consisting of oxygen and the diluent gas (Patent RF №2146536, priority from 20.03.2000,).

The disadvantage of this method is that it is used to supply the patient with only one mixture of gases during the procedure and only through the respiratory mask with strictly defined parameters of the physical state of the gas mixture (temperature, pressure, percentage of components), which prevents an individual approach to the patient. Such influence is not always overcomes the inertia of the biological object and, as a consequence, does not provide the efficiency response of the organism itself, i.e. its ability to restore its physiological functions. In addition, a very limited range of influence on therapeutic and redox effects.

There is also known a method of treatment of a biological object, which regulated the flow of a multicomponent gas mixture to mask the circulation flow performed to remove carbon dioxide (RF Patent No. 2072241, priority dated 20.09.1995,).

This sposobnost be approached individually to the patient by controlled flow of a multicomponent gas mixture. However, the impact of the circulation flow does not provide the desired therapeutic effect and does not affect the inertia of the biological object and, as a consequence, does not provide the efficiency response of the organism itself, i.e. its ability to restore its physiological functions. In addition, a very limited range of influence on therapeutic and redox effects.

Disclosure of inventions

The objective of the invention is to provide a method of regulation of the physiological condition of a biological object by mixtures of gases, providing the activation of redox and energy processes in biological objects of different levels of structural and functional organization, increase of specific and nonspecific adaptation of biological objects to changes in the environment, improvement of therapeutic effect when exposed to a biological object with a simultaneous increase in its resistance and enhance the body's ability to restore its physiological functions. In particular, the objective of the method is to expand the scope of an oxygen-containing gas mixtures in the treatment of bronchopulmonary, cardiovascular diseases, including chronic nature, when providing the first m the health care as anesthesia, as a rehabilitation tool in the postoperative period for withdrawal syndrome, drug dependence, and in other cases.

The objective of the invention is solved by the method of regulation of the physiological condition of a biological object by gas mixtures characterized by the fact that on the biological object placed in the medium with a content of at least one of gas, put gas mixture, as one component of which is oxygen, and this energy is carried out for at least one procedure in a cyclic mode with a certain regularity, providing saturation and/or desaturation of at least one component of the mixture of gases in the cells of biological tissue of the object by the given algorithm, and the number of procedures and their frequency depends on the number storeroom and/or desaturases gases and their degree of saturation and/or desaturation.

The saturation and/or exercise desaturation by creating a difference in partial pressure between one of the components affecting the biological object gaseous mixture and at least one of the components of the original mixture of gases tissue of a biological object.

The problem is solved also by the fact that the saturation and/or desaturation carried out by changing and/or composition of the gas mixture, acting on a biological object, by changing the number of affecting a biological entity, a mixture of gases, and maintain the constancy of the temperature affecting the biological object is a mixture of gases or temperature changes affecting the biological object mixture of gases.

The problem is solved also by the fact that the saturation and/or desaturation carried out by changing the pressure and/or composition of the mixture of gases surrounding the biological object and forming environment.

The problem is solved also by the fact that the saturation and/or exercise desaturation with the displacement of at least one of the components of the original mixture of gases tissue of a biological object.

The problem is solved also by the fact that the saturation and/or desaturation carried out periodically, for example, the saturation is carried out periodically with the subsequent desaturation.

The saturation and/or exercise desaturation with periodic displacement of at least one of the components of the original mixture of gases tissue of a biological object and replace it with one of the components affecting the biological object mixture of gases.

The problem is solved also by the fact that the saturation and/or desaturation carried out at a constant speed, for example, by introducing into the biological object is a mixture of gases at a constant speed.

Ass the cha is solved by the that saturation and/or exercise desaturation with variable speed, for example, by introducing into the biological object is a mixture of gases with variable speed.

The problem is solved also by the fact that the saturation and/or exercise desaturation introduction to biological object is a mixture of gases containing as one component of helium and/or argon and/or xenon and/or krypton, and/or neon, and/or nitrogen and/or hydrogen and/or sulfur hexafluoride, and/or methane and/or nitrous oxide and /or mixtures thereof.

The specified exposure to gas mixtures on biological object passes through the respiratory system of a biological object and/or the skin, through the skin, this effect can be done locally.

To enhance the effect of the addition to the mixture of gases that affect the biological object, enter englishusa substances and/ or therapeutic agent.

The essence of the invention consists in a cyclic effect within one procedure of the gas molecules at synapses of the nervous system and structure of cells, carried out under conditions ensuring a certain degree of saturation and/or desaturation set of gases for a given algorithm, which in some cases is necessary and complete replacement of one breathing gas mixture to another. The ongoing impact with cycle having a certain Zack is the principle, enables the creation, diffusion and protivogrippoznyh flow of molecules of different gases, which allows for a certain predetermined algorithm saturation and/or Desaturate at least one predetermined gas, and thereby to provide a series of changes of physiological processes at the cellular level, which positively affects the physiological mobilization of body reserves.

When you change the physical characteristics of the exposure process and/or the quantitative and qualitative composition affecting the gas mixture oxygen content in the composition of each mixture is maintained within the range 12-95%. The gas mixture can enter through the respiratory mask, and/or via an endotracheal tube and/or through the helmet, and/or in the chamber of intensive therapy, and/or under the local cap. Oxygen-containing gas mixture is introduced into a natural or forced mode. Exposure is carried out at a barometric pressure of 0.35-4 kgf/cm2and at a temperature of 18-100 degrees Celsius. The time of the procedure can range from 4 seconds to 24 hours, within which is provided a cyclic mode of exposure to a mixture of gases. Biological object can be exposed to this mixture during the period of time up to 7 days. The composition of the oxygen-containing gas mixture may enter englishusa substances and/or therapeutic agent.

Procedures cyclical effects on the biological object is carried out periodically to further enhance therapeutic effect, as established by a particular algorithm breaks allow the body to adapt effectively. Such effects, if necessary, can be carried out with simultaneous displacement of the source gas mixture of a biological object by providing one of the components of a mixture gas of a higher partial pressure than that of one of the gases found in the cells of a biological object, or by lowering or raising the pressure of the surrounding biological environment object.

When the change in the physical characteristics and/or quantitative and qualitative composition of the replacement of the gas mixture oxygen content in the composition of each mixture is maintained within the range 12-92%. When preparing introduced into a biological entity, a mixture of gases as one of the components used helium and/or argon and/or xenon and/or krypton, and/or nitrogen and/or hydrogen and/or neon, and/or sulfur hexafluoride, and/or methane and/or nitrous oxide, or mixtures thereof. In the process of replacing one gas mixture to another produce additional change of the quantitative and qualitative composition and/or physical characteristics of the surrogate mixture. The processes of saturation and/or desaturation of elitesecurity - saturation the same or different gases cells of a biological object, carried out in a cyclic mode, accompanied by a physico-chemical interaction diffusing in one direction or towards each other molecules of the same or different gases with molecules, organelles, synapses and cell membranes. As a result, when the shift algorithm given of the processes of saturation and desaturation, each of which is carried out in a cyclic mode with a certain regularity, it was found that for even one procedure is a series of physiological changes in the body - the change of osmotic pressure, lowering of thresholds of excitability of cells, peripheral blood flow, etc. that ultimately facilitates effective therapeutic effect on the body and increases the body's resistance.

Introduction the composition of the gas mixtures englishusa substances and remedies extends the scope of application of the method. It can be used in the treatment of bronchopulmonary, cardiovascular diseases, including chronic nature, first aid, as an anesthetic, as a rehabilitation tool in the postoperative period for withdrawal syndrome, drug dependence, and in other cases when you need to increase the overall resistance of the organism.

% The SS effects on the biological object by mixtures of gases may be forced replacement of one gas mixture to another. While the composition of the mixture of gases can enter the same with other gases partial pressure or other of the above gases. Forced eviction is a mixture of gases from the cells of a biological object is due to the higher partial pressure of at least one of the components of the input gas mixture, than any of the selected gas source mixture, or by lowering or raising the pressure of the living body environment. It should be noted the fact that the surrounding biological object environment can be in the form of a liquid, in which is introduced one of the gases.

It was established that in the variations described above, impacts on the biological object is the activation of the transmembrane and intracellular metabolism, activation of tissue respiration, synthesis of hormones, indicators and other biologically active substances, the shift of the processes of adaptation in the direction of anabolic stage and, as a consequence, the enhancement of therapeutic effect and increase the overall resistance of the organism.

When applying mixtures of gases identified as such physiological effects of the activation of bioelectric brain activity, suppression of emissions catecholamines, activation of tissue respiration, stabilizing and improving the General immunity of the body.

The essence of the proposed method of posn is placed on the examples. In all cells of the human body as a biological object under normal barometric pressure dissolved from 1 to 2 liters of nitrogen. When breathing helium-oxygen mixture, when the partial pressure of nitrogen in the cell is greater than its partial pressure in the mixture, the nitrogen tends to diffuse out of the cells and molecules of helium occupy his place. Is the saturation of cells with helium so-called simultaneous massage of the body's cells moving in one direction or another gas molecules. Cyclic mode of procedure provides the greatest impact on the biological object and the physiological state of the organism.

This same effect is observed when cyclic exposure to other mixtures of gases, which are injected inert gases such as helium, argon, neon, xenon, krypton, and other gases such as nitrogen, hydrogen, sulfur hexafluoride, methane, nitrous oxide, etc. and mixtures thereof.

It is established that the saturation, and hence the desaturation of the gases in the cells of different tissues of a biological object varies, so protivogrippoznye gases in these tissues occurs varies. The degree of saturation of tissues gases regulate the time of impact, the difference of partial pressure of a specific gas in the environment and the cells of the biological object(tissues, bodies), method of loading and physical state of the gas mixture, temperature, humidity, gases, and pressure change the environment.

In particular, it was found that helium-oxygen mixture is particularly relevant to its temperature. Heating of the mixture substantially above body temperature ensures uniformity and high efficiency heat conductive paths and lung tissue of man as a biological object with improved rheological properties of sputum, the facilitation of drainage, improve capillary blood flow in the lungs and initiation of thermo - and chemoreceptors.

A mixture of gases containing oxygen and one or more of these gases, serves in the human body cyclically during the procedure while ensuring saturation and/or desaturation. Conducting saturation and/or desaturation in cyclic mode provides additional therapeutic effect due to the so-called massage at the cellular level. The cycle time can be selected from one inhalation (approximately 4 seconds) to 24 hours, break time can be the same - this is related to the effects of various gases in different fabrics and with the physical condition of the person, adequate to his disease. After entering gas mixture establish a break, the duration of which can vary from 5 seconds to 7 days.

Time is Turzii and desaturation is determined by the composition of the gas mixture, the ambient pressure, the optimum value of which is in the range from 0.35 to 4 kgf/cm2. Conducted numerous experiments indicate that 24 hours is almost complete desaturation and saturation even bone tissue oxygen-containing gas mixtures. Conducting impact of gas mixtures on the body in circular mode and a predetermined algorithm allows the effects on certain cells of various tissues, including the bone address. It is set in advance and depends on the state of the organism and the specific tasks defined by the presence of a specific problem or disease, as well as the nature of the disease, in particular depending on the form of the disease, acute or chronic.

The number of variations of oxygen-containing gas mixtures, characterized by different physical condition and quantitative characteristics, the percentage included in the composition of the gas mixture components is not limited.

For each patient in each case the exposure parameters, providing a cyclic mode of action, are selected individually. Thus in addition to monitoring the patient's condition, compliance with preset modes, their sequence, and the like, it is necessary to track who and the level of saturation, so as not to cause the effect, the reverse treatment. With all the changes in the physical characteristics and/or quantitative and qualitative composition of the replacement of the gas mixture oxygen content in the composition of each mixture should be within 12%-95%.

In some cases, effects on the biological object in the process of replacing one gas mixture to another also produce additional change of the quantitative and qualitative composition and/or physical characteristics of the original gas mixture, and the environment in which is placed a biological object.

Acting on a biological object, a mixture of gases enter through the respiratory mask or through an endotracheal tube, or through a helmet, or in the chamber of intensive therapy, or under local control, or when they are combined. It allows you to either localize the impact of the process of saturation - desaturation of the body of gas mixtures on any site, or distribute it on the entire body.

The possibility of introducing a mixture of gases through the respiratory mask or through an endotracheal tube, or through the helmet together with artificial blood, blood saturation anesthetic gas xenon or krypton, significantly extends the application of the method when conducting surgical operations.

The method may be performed when the temperature of the gas mixtures from 18 to 100 degrees Celsius.

Quantitative and qualitative composition introduced into the biological object gas mixture, the components and the procedure for the introduction of mixtures of pre-determined depending on the affected tissues of a person and their state, and in the process influence of the gas mixtures and their possible substitution maintain constant control over the status of the human body and its response.

Option of carrying out the invention

The claimed invention was tested as follows. The patient is exposed to mixtures of gases, previously examined by medical personnel. When studied his medical history revealed a diagnosis is determined by its initial state at the current temperature of the body, the blood, blood pressure, electrocardiogram of the heart and, if necessary, x-ray of the lungs and upper respiratory tract. The need to control other indicators of the physiological state of the patient was established by the attending physician. Then determined the required composition of the input gas mixture, the form and the mode of its introduction.

Depending on the disease the patient was placed either in the corresponding closed volume with a specific gas environment, or, for example, physiotherapy. It was selected the desired input mode of the mixture of gases, its cyclical time and the speed of impact. The mixture of gases introduced through the respiratory mask, or through an endotracheal tube, or through a helmet, or in the chamber of intensive therapy, or under local control, or when they are combined. In the process impact on the patient mixtures of gases has also been in control of its physiological state and degree of saturation. The degree of saturation was determined by calculation or experimentally. To determine the degree of saturation used oximeter.

In some cases, the process needs to computerize the purpose of process control input gas mixture, its composition and quantity, pressure and simultaneous control of the physiological state of the patient.

The nature of the procedure and various ways of influence, usually established depending on the individual characteristics and the patient's condition and the nature of the disease.

So, if necessary provided with slow rise in the partial pressure of oxygen in the blood by changing the oxygen content in the gas mixture from 21 to 35 to 40%, or by changing the content of another component of the gas mixture. It is established that increase the oxygen content in the blood is not only due to the ventilation, but also due to protivogrippoznye of oxygen in the tissues. While physical properties of gases, temperature, especially if it means what Ino above thermoneutral, play a significant positive role. Below are concrete examples of the impact on the human body by the claimed method.

Example 1. The patient (male 52 years) with acute exacerbation of bronchial asthma on the background of erysipelas of the right tibia (swelling, purple color tibia) with the main complaints of respiratory distress already in mild physical activity and pain when walking was exposed to an oxygen-helium gas mixture.

To establish the objective condition of the patient is first conducted a blood test determined blood pressure, body temperature, electrocardiogram and chest x-ray of the lungs. Additionally, determine the content of oxygen in the blood, heart rate, percentage of carbon dioxide in the exhaled mixture. These parameters patient was periodically monitored during the procedure, exposure to oxygen-helium gas mixture. The parameters of the initial state of the patient was established procedure parameters: its duration, frequency and number of procedures required, the cyclical impact of oxygen-helium gas mixture, the temperature of this mixture, the percentage of oxygen in its composition. When this was carried out by slow gradual increase in the partial pressure of oxygen in the gas mixture from 25 to 35%. P is after 3-7 minutes of exposure, the percentage of oxygen in the blood and carbon dioxide in the exhaled gas mixture stabilized. Once the process is stabilized, the influence of the gas mixture was interrupted for 5-7 minutes, then the exposure was repeated. It was found that during exposure to a gas mixture is partial saturation - tissue helium and nitrogen desaturation, upon termination of the exposure process goes in the opposite direction. Cycle effects were repeated three to five times, with a gradual increase in the concentration of oxygen in the gas mixture. After this was established a long break, optimally from 3 to 4 hours, but not more than one day. The patient was monitored during exposure and during breaks.

As a result of treatment, consisting of 8 sessions daily for 5 cycles for 5 minutes exposure and 5 minutes of rest each patient's condition improved dramatically. Virtually disappeared respiratory failure, stopped the attacks of bronchial asthma, pain in the legs stopped, edema slept. At the site of inflammation remained only pigmentation.

Example 2. The influence of oxygen-helium gas mixture with a temperature of +80°-+85°subjected the patient complaining of lack of energy, fatigue, poor sleep and fatigue in the morning, heaviness, lack of exercise. Age 59 years, male. Blood pressure during examination - 90/60. Diagnosed vegeto-vascular dystonia of hypotonic type.

In ECENA 5 days, the patient breathed through 6 minutes of the specified mixture with breaks in 10 minutes. The oxygen content was not less than 21%. This provides saturation of tissue helium followed by desaturation.

Following these sessions, the patient significantly increased tone, decreased fatigue, improved sleep, decreased heaviness, pressure normalized. AD - 120/70.

Example 3. The patient with chronic heart and lung failure on the background of encumbrances long-term mental and psycho-physical strain were subjected to sequential exposure to multiple oxygen-containing gas mixtures. The patient is 52 years old.

In this case, the patient was placed in a pressure chamber filled with air as the environment. Ambient temperature was maintained order +28-+32°C, pressure up to 3 kgf/cm2. The impact on the patient when the pressure was carried out for 20 minutes. Then the patient through the mask filed oxygen-helium gas mixture and subjected to decompression to 1.2 kgf/cm2within 15 minutes, after which he filed an oxygen-argon gas mixture for 15 minutes and again spent decompression to atmospheric pressure.

Because of this variable was carried out saturation with first one, then another gas. The oxygen content in gas mixtures were left constant and equal to 23-25%.

As a result of even require the procedures improved health of the patient, improved respiratory function, ECG - normalized pulse disappeared systole, the patient is considered satisfactory with the right to work. Such results when conventional therapy is achieved very slowly. Achieved results can be explained unconventional conduct regimes influence of the gas mixture to the patient, since the main impact criterion was to ensure saturation and desaturation of cells, tissues, activating the vital processes of the body due to rotation effects on cells by gas molecules in opposite directions.

Example 4. A patient with vascular disorders, and pulmonary insufficiency was placed in a hyperbaric chamber. The patient is breathing air at normal pressure. The chamber was closed and reduced pressure up to 0.6 kgf/cm2. At this pressure, the patient was breathing rarefied air for 3-4 minutes, and then the pressure was restored to normal, after 5-6 minutes, the procedure was repeated. During the procedure such cycles were performed 5-6 times daily, the rate of 6-7 days.

Objectively recovered respiratory capacity and improved crownappointed vessels. The control pistons 5 saturation and change its parameters (time, speed, quantity) showed its significant impact on the condition of the patient.

Example 5. A group of Aquanauts of five che who ovec underwent rehabilitation after a number of dives. The procedure was performed by placing the entire group in the chamber. The first group was exposed to air at normal pressure. Then the chamber was closed and increased the air pressure to 2.0 kgf/cm2. At this pressure the group breathed compressed air for 10 minutes and then spent decompression to normal pressure. The procedure was repeated 3-4 times, with each subsequent time, the time pressure was reduced to 2 minutes. Course of action - 3-5 days.

The control parameters of an impact within one procedure showed the dependency rehabilitation of Aquanauts on the degree of saturation. As a result of the medical Commission, all members of the group were considered fit for further professional work.

Industrial applicability

The claimed invention was tested with the involvement of 25 health professionals. The results of the impact on patients mixtures of gases by the present method showed a very high effectiveness in the treatment and rehabilitation. The claimed method opens wide possibilities of non-medical treatment of patients, which plays a huge role for patients with allergic reactions to chemicals. Moreover, the possibility of treatment of various diseases, including allergic different nature. High will put the global results when conducting rehabilitation procedures will allow for broad prevention of various diseases, to use this method to restore physical and other disabilities.

Thus, the present method will be widely used in medicine, health facilities and training of staff exposed in the process of severe psycho-physical stress.

1. The method of regulation of the physiological condition of a biological object by mixtures of gases, characterized in that the biological object placed in the environment with the content, at least one of gas, put gas mixture, as one component of which is oxygen, and this energy is carried out for at least one procedure in a cyclic mode with a certain regularity, providing saturation and/or desaturation of at least one component of the mixture of gases in the cells of biological tissue of the object by the given algorithm, and the number of procedures and their frequency depends on the number storeroom and/or desaturases gases and their degree of saturation and/or desaturation.

2. The method according to claim 1, characterized in that the saturation and/or exercise desaturation by creating a difference in partial pressure between one of the components affecting the biological object gaseous mixture and at least one of the components of the original mixture gas is tissue of a biological object.

3. The method according to claim 1, characterized in that the saturation and/or desaturation carried out by changing the pressure and/or composition of a mixture of gases that affect the biological object.

4. The method according to claim 1, characterized in that the saturation and/or desaturation carried out by changing the number of affecting a biological entity, a mixture of gases.

5. The method according to claim 1, characterized in that the saturation and/or desaturation carried out with maintaining the constancy of the temperature affecting the biological object mixture of gases.

6. The method according to claim 1, characterized in that the saturation and/or desaturation is performed with the temperature change affecting the biological object mixture of gases.

7. The method according to claim 1, characterized in that the saturation and/or desaturation carried out by changing the pressure and/or composition of the mixture of gases surrounding the biological object and forming environment.

8. The method according to claim 1, characterized in that the saturation and/or exercise desaturation with the displacement of at least one of the components of the original mixture of gases tissue of a biological object.

9. The method according to claim 1, characterized in that the saturation and/or desaturation carried out periodically.

10. The method according to claim 1, characterized in that the saturation is carried out periodically with the subsequent desaturation.

11. The method according to claim 1 or 9, characterized in that the saturation and/or exercise desaturation with periodic displacement of at least one of the components of the original mixture of gases tissue of a biological object and replace it with one of the components affecting the biological object mixture of gases.

12. The method according to claim 1, characterized in that the saturation and/or desaturation is performed with a constant velocity.

13. The method according to item 12, characterized in that the saturation and/or exercise desaturation introduction to biological object is a mixture of gases at a constant speed.

14. The method according to claim 1, characterized in that the saturation and/or exercise desaturation with variable speed.

15. The method according to claim 1, characterized in that the saturation and/or exercise desaturation introduction to biological object is a mixture of gases with variable speed.

16. The method according to claim 1, characterized in that the saturation and/or exercise desaturation introduction to biological object is a mixture of gases containing as one component of helium and/or argon and/or xenon and/or krypton, and/or neon, and/or nitrogen and/or hydrogen and/or sulfur hexafluoride, and/or methane and/or nitrous oxide, and/or mixtures thereof.

17. The method according to claim 1, characterized in that the effect of gas mixture on the biological object passes through the stomach is compulsory system of a biological object and/or the skin.

18. The method according to claim 1, characterized in that the saturation and/or exercise desaturation through the skin locally.

19. The method according to claim 1 or 16, characterized in that in the mixture of gases that affect the biological object, in addition enter englishusa substances.

20. The method according to claim 1 or 16, or 17, characterized in that in the mixture of gases that affect the biological object, impose additional therapeutic agent.

21. The method according to claim 1 or 16, or 17, characterized in that in the mixture of gases that affect the biological object, in addition enter englishusa substances and medical products.



 

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2 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: method involves daily administering individually dosed exercise stress. Additional respiration sessions are carried out with artificial gas mixture in isolating respirators 20-30 min long before and after physical activity under normal atmospheric conditions beginning from the second day after decompression end. The gas mixture has 50% of oxygen and 50% of helium. Exercise stress duration is gradually increased from 10-15 min to 45-60 min without increasing power.

EFFECT: enhanced effectiveness of treatment; excluded risk of lung oxygen toxicosis.

FIELD: medicine.

SUBSTANCE: method involves warming with inhalation and supplying oxygen to the organism. Artificial respiratory gas mixture is used containing oxygen in the amount of 49-51 % by volume, and the rest being helium. Mixture temperature is to be equal to 40-44°C.

EFFECT: improved and accelerated warming process; reduced risk of complications causable by medical oxygen.

FIELD: medicine.

SUBSTANCE: method involves following hemodynamic and peripheral saturation state, respiration rate and acid-base balance values, after having stabilized general patient condition and repaired consciousness. Neurological status is additionally estimated by recording somatosensory evoked potentials with N11-13 and N13-18 intervals. The N11-13 and N13-18 intervals remaining at the preoperative level or becoming shorter, respiratory support reduction starts and the patient is transferred to spontaneous respiration mode. The N11-13 and N13-18 intervals growth being found to be 0.2 ms as large relative to preoperative period or their instability being observed for 30-60 min, transfer to spontaneous respiration mode is to be stopped. After having transferred a patient to spontaneous respiration mode in the cases of N11-13 and N13-18 intervals reduction below the preoperative period level, somatosensory evoked potential control lasts for 2 h. The intervals remaining unchanged at the preoperative period level or their oscillation being within ±0.1 ms, somatosensory evoked potential control lasts for 6 h. The hemodynamic and peripheral saturation state, respiration rate and acid-base balance values monitoring procedure is continued during 12 h after having separated a patient from respirator.

EFFECT: enhanced effectiveness in determining optimum moment for reducing respiration support.

FIELD: medical engineering.

SUBSTANCE: method involves using pacifier as support to keep hygienic sanitary protection device on baby face holding it with mouth. Convex mask repeating face profile fulfils pacifier restriction disk function. The mask has an opening at nose level for mounting filtering member and openings for eyes.

EFFECT: enhanced effectiveness in protecting children against harmful action of environment.

5 cl, 3 dwg

FIELD: medicine, psychotherapy.

SUBSTANCE: the method combines an interrogation and psychotherapeutic discussion. Then, at the first stage a patient has got a habit to breathe at signals at their length corresponding to signal of respiratory training equipment: inhalation 2-3 sec, expiration 3-4 sec and pause 3-4 sec. From training to training it is necessary to decrease air volume used for inhalation. On training the algorithm of patient's breathing it is necessary to carry out the second stage in case of patient's comfort state. It should last for about 3 h daily. During the second stage one should decrease air volume necessary for inhalation-expiration cycle up to 0.2-0.1 l. At achieving the duration of control pause of respiration being 60-90 sec it is necessary to start the third stage to maintain the following algorithm of respiration: inhalation 2-3 sec, expiration 3-4 sec, pause 3-4 sec. At air volume necessary for inhalation at the state of rest being 0.2-0.1 l one should conduct control pause being equal to 60-90 sec as a standard. In case of deviation trainings should be performed at the volume to restore the control value. The innovation helps to get rid of tobacco smoking due to saturating patient's blood with carbonic acid.

EFFECT: higher efficiency of therapy.

1 cl, 2 ex

FIELD: medicine, in particular, exercising of respiratory organs in moderate hypoxia and hypercapnia mode with adjustable resistance to inhalation and expiration.

SUBSTANCE: respiratory exerciser has cylindrical mixing chamber with narrowed upper part, respiratory pipe connected to cylindrical mixing chamber, and bottom with perforations provided in its peripheral portion. Bottom of cylindrical chamber is made doubled. Members of porous material having predetermined density are located within bottom cavity. Central part of bottom is equipped with channel provided within cylindrical chamber and communicating with atmosphere. Inhalation indicator provided within channel is made in the form of movable piston member. Respiratory pipe is equipped with acoustic expiration indicator made in the form of unidirectional resonance whistle. Bottom inner cavity may be provided with additional replaceable loading inserts formed as film disks with openings having predetermined area and flexible loop attached to upper part of cylindrical chamber and having adjustable length.

EFFECT: reduced restrictions in orientation and fixing of exerciser position during usage and provision for indicating quality of expiration cycle.

3 cl, 2 dwg

FIELD: medicine, pediatrics, anesthesiology.

SUBSTANCE: at induction of general anesthesia one should conduct traditional two-lung ventilation at the mode of positive pressure at the end of expiration, on visualizing pleural cavity one should change for high-frequency pulmonary ventilation at respiration frequency being 130-150 cycles/min, respiratory volume of 3-6 l, the ratio of inhalation to expiration being 1:1 and fractional content of oxygen being 0.7-0.8. During performing the stage requiring lung's stillness it is necessary to conduct artificial ventilation in counter-lateral lung at the mode of positive pressure being at the end of expiration, on finishing that stage one should start high-frequency artificial ventilation; operation should be finished with traditional two-lung ventilation. The innovation provides stabilization of hemodynamics and safety of gaseous homeostasis.

EFFECT: higher efficiency.

2 ex

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