Method for increasing nonspecific organism activity under watch working schedule conditions in arctic north

FIELD: medicine.

SUBSTANCE: method involves administering one of antyhypoxidant-antioxidant medicaments on empty stomach in age-specific dose before exposing a patient to cyclic treatment with gas medium. Hypoxi-hypercapnic gas mixture is applied as respiratory gas medium. Then, the patient is moved up for breathing with air-oxygen mixture. TcPO2 and/or SO2 restoration period being over, repeated hypoxi-hypercapnic treatment cycle is applied. The mentioned patient treatment cycles are applied in succession 4-10 times.

EFFECT: enhanced effectiveness of treatment; increased adaptation and reduced risk of side effects.

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The invention relates to medicine, to methods for increasing the nonspecific resistance of the organism in particular when the rotational method of work in the Far North.

A known way to increase nonspecific resistance in the form of impact on the patient hypoxic mixture under normobaric conditions, and affect the mixture with 9-9,5% oxygen and 91.0-90.5% nitrogen within 3-5 min, the effect of hypoxic mixture alternate breathing atmospheric air for 3-5 min, and spend 4-12 cycles after 1 day (see patent RU No. 1264949, class. And 61 G 10/00, 23.10.1986).

However, the use of this method in the Far North of the alien population (employees on rotational basis) is often accompanied by symptoms of low tolerance of hypoxic stimulus. So, if the conditions of the European part of Russia reduced tolerability of therapy is not more than 1,0±0.2% of cases, the use of this method causes the symptoms of low tolerance, manifested in the feeling of lack of air, or sudden shortness of breath, and renounce breathing gas mixture; the development of tachycardia with the increasing number of heart contractions by more than 30 beats per 1 minute or bradycardia, severe pallor or flushing of the skin and severe increase or decrease in blood pressure, which, in methodological terms is m, is a signal to stop the supply of the gas mixture.

Studies have shown that workers in gas companies in terms of rotational and forwarding method in the Far North has a number of features that affect the body adversely affected. Climatic conditions in the Far North is recognized as extreme due to the impact of various climatic, geophysical and cosmic factors that can lead to the development of stress reactions among workers on a rotational schedule in the Far North.

As you know, on the level of physiological processes stress means hypoxia. State of hypoxia occurs when the reduction of oxygen, the reduction of its content in air or in violation of transport that is characteristic of people living in the Far North. Therefore, adaptation to hypoxia is the prevention of the depletion of adaptive reserves under stress of any Genesis. Adaptive reactions that occur during adaptation to hypoxia, has been well developed in the process of evolution. According to the concept of cross-adaptation, the emergence of resistance to one extreme factor increases the body's resistance to a range of different effects.

A striking example of the formation of cross-adaptation can serve the human exposure to normobaric hypoxia. Adaptation in developing not only to the lack of oxygen, but also to several other factors, in particular, produces a certain resistance to infections, physical exercise, desynchronosis, and other factors. This result is not that other, as the increase in total resistance (specific resistance) of the body, which is based on the genetically determined structural-functional changes. But as a consequence of these changes is to increase the energy potential of the organism.

The objective of the invention is to reduce side effects and increase the efficiency of the method when the rotational method of work in the Far North.

Result from the use of the invention is achieved due to the fact that the way to increase nonspecific resistance of the organism when the rotational method of work in the Far North, which consists in the fact that cyclically affect the respiratory gas environment on the patient, in the morning one hour prior to the cyclical impact on the patient gas environment take on an empty stomach one of the drug class adaptogenes in combination with one of the drug class antihypoxants-antioxidants in age-related dosage as respiratory gas environment using HYPOXI-hypercapnic gas mixture with a concentration of About2not less than 9% and what concentratie CO 2no more than 3%, while increase the partial pressure of carbon dioxide (PCO2) not more than 42 mm Hg from their original values, then the patient is transferred to the breath of air-oxygen mixture with a concentration of About2not more than 40%at the end of the recovery period, Tsro2and/or So2re-cycle HYPOXI-hypercapnic exposure, and the above sequence of cycles impact on the patient spend from 4 to 10 times.

As a drug class antihypoxants-antioxidants take lipoxen, emoxipin, Mexidol or ubiquinone.

As a drug class adaptogenes take extracts of Siberian ginseng, aralia Manchu or Chinese Magnolia vine.

The method is as follows.

In accordance with the indications and contraindications for the methodical recommendations of the Ministry of health of the Russian Federation (Normobaric hypoxic therapy. - M., 2001. Ed. 2-E.) select a group of patients from among persons who work on a rotational schedule in the Far North. A day after their arrival rotational service in the morning on an empty stomach blood test to assess the nature of adaptive responses according to the method Phharmacy et al. (1998). If the nature of the adaptive response of the organism favorable response training (RT), the reaction of m is th activation (PCA) reaction of increased activation (RPA), then the next day prescribe a course on the proposed way to increase nonspecific resistance of the organism. If the nature of the adaptive response of the organism to adverse acute stress (OS), chronic stress (CS), the reaction preactivation (RP), is administered in a dosage of age one of the drugs of the class adaptogenes (extracts of Siberian ginseng, Manchurian aralia, schisandra chinensis and other) and one of the drug class antihypoxants-antioxidants (lipoxen, emoxipin, Mexidol, ubiquinone ubiquinone and other). After normalization of the nature of adaptive reactions are prescribed a course on the proposed way to increase nonspecific resistance of the organism.

All patients, at least an hour before breathing HYPOXI-hypercapnic mixture in combination with the breath of air-oxygen mixture in the morning on an empty stomach, is administered in a dosage of age one of the drugs of the class adaptogenes (extracts of Siberian ginseng, aralia Manchu or Chinese Magnolia vine) and one of the drug class antihypoxants-antioxidants (lipoxen, emoxipin, Mexidol or ubiquinone).

Before the course, the doctor does the respiratory HYPOXI-hypercapnic test for determining the acceptability of HYPOXI-hypercapnic and air-oxygen mixtures, which when Otsu is under negative reactions of the patient is regarded as the first session of the course.

Breathing gas environments are conducted through the mask from the anaesthetic machine under the constant supervision of Tsro2or So2and RNO2that eliminates the possibility of changing these parameters set by the physician levels and, consequently, the development of non-repayable forms of hypoxia and hypercapnia.

When HYPOXI-hypercapnic test the breath of HYPOXI-hypercapnic gas mixture is conducted to reduce Tsro2not more than 50% or So2not more than 30% of their original values and increasing the PCO2not more than 42 mm Hg As only one of these parameters reaches the specified level, a patient on a breath of air-oxygen mixture with a concentration of About2not more than 40%. At the end of the recovery period, Tsro2or So2to the normative values of a second cycle of HYPOXI-hypercapnic exposure. The number of HYPOXI-hypercapnic and air-oxygen cycle impacts must be at least 3-X.

The positive effect of the proposed method is confirmed by the following comparative research.

The studies were performed in 60 women workers "YAMBURGGAZDOBYCHA" of reproductive age with chronic nonspecific oophoritis. Age of women surveyed ranged from 23 to 40 years and the average was 34.2�B1; 2.2 years. The patients were divided into 2 groups of 30 people each.

In the first group included women who underwent hypoxic stimulation of nonspecific resistance of the organism by known methods. In the second group includes women who have completed treatment by the proposed method.

In group I the methodology of the course of therapy was inhalation of hypoxic gas mixture containing 10% oxygen and 90% nitrogen gas (SGN-10) with a constant control over the degree of hypoxia on changes in indicators of Tsro2or So2. Carried out individual selection modes hypoxic exposure. Before beginning a course of therapy conducted hypoxic test - breath SGN-10 to reduce Tsro250% or So230% from the original values with the subsequent breath atmospheric air to the full restoration of Tsro2or So2After the termination of the oscillation amplitude increase of Tsro2from one of hypoxic cycle to another during hypoxic test, which is the 1st session therapy, additionally gave another 3 to 10 hypoxic cycles.

When conducting therapy sessions followed the decline of Tsro2that was reduced by 10-50% or So25-30% of their original values. Then translated to the patient breathing the atmosphere is th air, at the end of the recovery period, Tsro2or So2spent the next cycle of hypoxic exposure. The number of hypoxic cycles in the session was established after the termination of the amplitude increase and stabilization of oscillation of Tsro2. The course was completed with a stable registration reduce the amplitude of oscillation of Tsro2from cycle to cycle, as well as normalizing the parameters of the kinetics of oxygen metabolism and indicators of adaptive reactions, which explored every 1-5 sessions.

In group II the methodology of the course of therapy to closely match the proposed method. A day after their arrival rotational service in the morning on an empty stomach took a blood test to evaluate the nature of adaptive reactions according to the method Phharmacy et al. (1998). If the nature of the adaptive response of the organism were favorable response training (RT), the reaction peaceful activation (PCA)reaction of increased activation (RPA), then the next day was prescribed a course of therapy to increase nonspecific resistance of the proposed method. If the nature of the adaptive response of the organism was adverse acute stress (OS), chronic stress (CS), the reaction preactivation (RP), were prescribed the drug class adaptogenes - extract leute is okocha barbed 30 drops in the morning on an empty stomach 30 minutes before a meal, and also the drug class antihypoxants-antioxidants - ubiquinone 0.03 (2 capsules) 3 times a day regardless of meal times. After normalization of the nature of adaptive reactions were prescribed course of treatment.

All patients of group II at least an hour before breathing HYPOXI-hypercapnic mixture in combination with the breath of air-oxygen mixture in the morning on an empty stomach was appointed extract of Eleutherococcus senticosus 30 drops and ubiquinone 0.03 (2 capsules).

Before the course the doctor spent the respiratory HYPOXI-hypercapnic test for determining the acceptability of HYPOXI-hypercapnic and air-oxygen mixtures, which in the absence of adverse reactions the patient was regarded as the first session of the course.

Breathing gas environments conducted through the mask from the anaesthetic machine under the constant supervision of Tsro2or So2and RNO2that ruled out the possibility of changing these parameters set by the physician levels and, consequently, the development of non-repayable forms of hypoxia and hypercapnia.

When HYPOXI-hypercapnic test the breath of HYPOXI-hypercapnic gas mixture is conducted to reduce Tsro2not more than 50%, or So2not more than 30% of their original values and increasing the PCO2not more than 42 mm Hg as soon As one of these pokazatel the th has reached a predetermined level, the patient was placed on a breath of air-oxygen mixture with a concentration of About230%. At the end of the recovery period, Tsro2or So2to normative values have repeated cycle of HYPOXI-hypercapnic exposure. The number of HYPOXI-hypercapnic and air-oxygen cycle impacts during the 1st session was 4. In subsequent sessions the number of cycles gradually brought up to 6-10. The duration of the session, as a rule, did not exceed 1.5 hours.

Comparative characteristic symptoms of reduced portability hypoxic stimulus in patients of groups I and II are presented in table. 1.

Table 1

Comparative characteristic symptoms of reduced portability hypoxic stimulus in patients of groups I and II
Symptoms reduced endurance (%)I groupGroup IIP
Shortness of breath3,3±3,10±3,0
The feeling of lack of air3,3±3,10±3,0
Pale skin0±3,03,3±3,1
Tachycardia6,7±3,10±3,
Bradycardia3,3±3,10±3,0
Increasing the GARDEN is more than 40 mm Hg6,7±3,10±3,0
Sweating3,3±3,10±3,0
ONLY26,6±8,13,3±3,1<0,001

As is seen in table. 1 data in the I-th group of patients with symptoms of reduced portability hypoxic stimulus was shown 8 times more frequently than in patients of the second group. It should be noted that occurred pale skin at the 1st women (3,3±3,1%), passing a course of therapy on the proposed method was transient and did not lead to the cessation of breathing, HYPOXI-hypercapnic mixture. At the same time, the patients of the I-th group took on subsequent sessions significantly reduced (3-5 times) the exposure time breathing a hypoxic mixture and gradually to 7-9 sessions to bring it to the required values. All this to achieve a positive effect demanded to increase the duration of the course, which averaged 29,6±2,2 sessions. Patients of the 11th group of positive results were achieved by 17,4±2,8 session (P<0,05).

When assessing what effektivnosti of the proposed method takes into account the duration of remission chronic nonspecific oophoritis after conducting courses of therapy in both groups of women. In the I-th group no exacerbation of symptoms after a course of therapy averaged 143±21 days, while in the II-nd group - 282±37 days (P<0,001), i.e. the period of remission was longer almost in 2 times.

1. The way to increase nonspecific resistance of the organism when the rotational method of work in the Far North, which consists in the fact that cyclically affect the respiratory gas environment on the patient, characterized in that in the morning one hour prior to the cyclical impact on the patient gas environment take on an empty stomach one of the drug class antihypoxants-antioxidants in age-related dosage as respiratory gas environment using HYPOXI-hypercapnic gas mixture with a concentration of About2not less than 9% and the concentration of CO2no more than 3%, while increase the partial pressure of carbon dioxidenot more than 42 mm Hg from their original values, then the patient is transferred to the breath of air-oxygen mixture with a concentration of About2not more than 40%at the end of the recovery periodand/orre-cycle HYPOXI-hypercapnic exposure, and the above sequence of cycles impact on the patient hold the t 4 to 10 times.

2. The method according to claim 1, characterized in that, as a drug class adaptogens take extracts of Siberian ginseng, aralia Manchu or Chinese Magnolia vine.

3. The method according to claim 1, characterized in that, as a drug class antihypoxants-antioxidants take lipoxen, emoxipin, Mexidol or ubiquinone.



 

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