Method for predicting disadaptive processes in women

FIELD: medicine, obstetrics.

SUBSTANCE: the present innovation deals with predicting disadaptive processes in women in dynamics of menstrual cycle. During menstrual cycle beginning since the 1st d to the 21st d one should detect the dynamics for alteration in coefficient of activity of syntoxic adaptation programs (CASAP), calculated by the following formula:

where CST - concentration of blood serotonin, AAT-III - activity of antithrombin III, Aaoa - total antioxidizing activity of plasma, CCD8+ - concentration of T-suppressors, Cad - concentration of blood adrenalin, Cα2MG - concentration of α2-macroglobulin, CMDA - concentration of malonic dialdehyde, CCD4+ - concentration of T-helpers. Moreover, normally CASAP value alters two-fold against the first day of the cycle - since 0.70 up to 1.40 on the 21st d of the cycle, at no alterations in CASAP value one should diagnose female disadaptive alterations leading to failed pregnancy. The innovation enables to perform diagnostics of disadaptive processes in women in dynamics of menstrual cycle followed by prognostic conclusion upon future pregnancy.

EFFECT: higher accuracy of diagnostics.

2 ex

 

The invention relates to medicine, in particular to obstetrics and gynecology,and can be used to diagnose disadaptive processes in women with altered menstrual cycle.

Known methods for diagnosing disorders of the menstrual cycle are mainly based on a cyclical process, duration of menstrual bleeding, pain, etc. are ignored adaptive processes, which are aimed at the compassion of a mother with a possible developing fetus (gander J.K., Lazarus JV, Morozov V.N. and other the Role of placental proteins in the maintenance of physiological functions in normal and pathological pregnancy// VNMC. - 1999. - V.6. No. 2. - S-95). It is shown that the dynamics of the menstrual cycle causes a constant change activity syntaxchecker and catatoxic adaptation programmes promoting nidali fertilized egg and failed fertilization removal of the functional layer of the endometrium with the egg (gander J.K., Lazarus JV, Morozov V.N. Psychoneuroimmunological features adaptive mechanisms of normal reproductive cycle in women// VNMC. - 2000. - V.7. No. 1. - S-101), clinically manifested menstrual bleeding.

The closest entity analog is a method for the diagnosis of premenstrual syndrome by Vegeta adistem and metabolic disorders (V.I. Kulakov Obstetric and gynecologic care. - L.: Medicine, 1995. - 408 C.). However, this method is difficult to account for these vascular, metabolic disorders and treated by different doctors in their own way, which is reflected in the treatment of this group of patients.

The present invention is a fundamentally new way to diagnose disadaptive processes in the modified menstrual cycle to enable adaptive programs syntaxchecker type, defined by the coefficient activation of adaptation programs (CUSP), which objectively reflects the degree of dominance of adaptation programs during the first 21 days of the menstrual cycle in normal women and the absence of the latter in women with altered menstrual cycle.

The method is as follows: turning the patient to the doctor is given a full clinical assessment, and the degree of inclusion of adaptive programs, which is a CUSP.

This ratio reflects the degree of activity of adaptation programs during the menstrual cycle and is defined as follows. The patient is taken fasting blood from the cubital vein in the amount of 10 ml on different days of the menstrual cycle (1, 7, 14, and 21 days). It explores the indices of antioxidant, pretioso the Delta and immune mechanisms and simultaneous determination of biologically active amines, in particular adrenaline and serotonin, by uniform methods. Then calculate the activity coefficient of adaptation programs:

where Carticlethe concentration of serotonin in the blood; Andat-IIIactivity of anti-thrombin III; Andthe AoA- the total antioxidant activity of plasma; CCD8+the concentration of T-suppressors; Chellthe concentration of adrenaline in the blood; Cα2mg- concentration α2 - macroglobulin; CMDAthe concentration of malondialdehyde; CCD4+the concentration of T-helper cells.

The concentration or activity used to calculate the values expressed in % of the mean values in healthy women during the menstrual cycle. The study was conducted on 40 women of childbearing age from 18 to 30 years.

In women with normal menstrual cycle ratio CUSP varies from 0.7 to 0.8 on day 1 of the menstrual cycle, to 7 days, it was increased to 0.9 to 1.0. On day 14 it was 1.1-1.2 and was maximal on day 21 of the menstrual cycle, amounting to 1.3-1.4.

In women with altered menstrual cycle indicator CUSP was almost unchanged compared with the first day of the cycle. 1 day cycle in this group of women were surveyed 40 women) ratio 0,70-0,80, after 7 days he was 0.81-0.90 or after 14 days of 0.82-0.92 and n is 21 days - 0,76-0,90. Therefore, the activity of adaptation programs is the measure of fertility and is aimed at the compassion of the mother to the developing fetus. Without these components cannot be normal childbearing, and determining the ratio of the CUSP, we can to the development of pregnancy to predict her miscarriage.

Example 1. Female L., age 29, in the study of blood on the adaptive capabilities discovered that the CUSP in the dynamics of the menstrual cycle was changed to 1 day from 0.75 (08.08.1998 year) to 0.80 after 7 days (14.08.1998 year). After 14 days he was 0.82 (21.08.1998 year) and after 21 days the value was 0,78 (28.08.1998 year). The menstrual cycle the woman is 28 days and clinical nothing stands out, but it had two miscarriages at 8 and 10 weeks of pregnancy, which is associated with the violation of the inclusion of adaptation programs.

Example 2. A woman Charles, 32 years old, has 4 miscarriage at 10, 9, 11 and 15 weeks of pregnancy. Menstrual cycles are normal, 28 days without features. During examination by a factor of CUSP identified the following indicators. On the first day he was 0.66 (16.05.2000 year), on the 7th day of - 0.68 (22.05.2000 year), on the 14th day of 0.71 (29.05.2000 years) and 21 day - 0,70 (05.06.2000 year). In other words, this woman shows no signs of inclusion of adaptation programs, what was the cause of Nevins the of pregnancy.

The way to diagnose disadaptive processes in women, leading to miscarriage, which consists in determining syntaxchecker and catatoxic adaptation programmes, characterized in that in the process of the menstrual cycle from 1 to 21 days determine the dynamics of changes of the activity coefficient of adaptation programs (CUSP), calculated by the formula

where Carticlethe concentration of serotonin in the blood AndAt-IIIactivity of anti-thrombin III, Aaoa- the total antioxidant activity of plasma, WithSD8+the concentration of T-suppressors,hellthe concentration of adrenaline in the blood, Withα2mg- concentration α2-macroglobulin, CMDAthe concentration of malondialdehyde WithCD4+the concentration of T-helper cells, while in normal fluctuation coefficient CUSP changed two times compared to the first day of the cycle - with 0.70 to 1.40 on day 21 of the cycle, in the absence of oscillations factor CUSP diagnosed women disadaptive changes, leading to miscarriage.



 

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