Biologically active food supplement for the prevention of iodine deficiency and optimization of iodine metabolism and food product containing it

 

(57) Abstract:

The invention relates to food industry, namely the production of biologically active additives to food, prevention of food products containing such dietary SUPPLEMENTS. Biologically active food Supplement contains synthetic organic compound with covalently bound iodine, selected from the group of carboxylic acids, unsaturated fatty acids, lipids, terpenes, alkanes, terpenoids, isoprene, peptides, polypeptides, amino acids, protein hydrolysates, protein hydrolysates, plant proteins, animal proteins, proteins of microbial origin and their various mixtures. In proteins, peptides, polypeptides, amino acids, polypeptide and protein hydrolysates iodine is covalently bonded in the 5 - and 3 - or 3-position of the phenolic cycle. Moreover, amino acids and proteins selected from the group of amino acids and proteins, not with thyroid hormone activity, which are conditions precluding condensation of tyrosine cores. Additional SUPPLEMENTS may contain organic compound with ecovalence iodine and/or inorganic iodine. BAA can be a prolonged fo the x complexes. The second object of the invention is a food product containing such food SUPPLEMENTS such as dairy product, milk product, meat product, bakery product, bread, beverage, juice, confectionery, baby food. The invention provides in the creation of food SUPPLEMENTS and food products containing the most physiological iodine-containing compounds of organic origin, is not a non-hormonal activity, an adequate biochemical peculiarities of iodine metabolism and are therefore able to provide the launch of its mechanisms of self-control and autoregulation. 2 C. and 17 C.p. f-crystals.

The invention relates to food industry, in particular to the field of biologically active additives to food, and can be used for the production of food SUPPLEMENTS and preventive foods containing dietary SUPPLEMENTS. Specifically this invention is directed to the prevention of iodine deficiency and optimization of iodine metabolism in the human body.

Iodine, being a structural element of the thyroid hormones, involved in the implementation of their biological functions is the regulation of growth and differentiation of tissues, control of metabolism and energy, heat production. Despite nanno have different degrees of iodine deficiency, typical of vast areas.

The importance and indispensability of iodine for normal development and functioning of living organisms induce to artificial enrichment of food products this trace element.

Known iodized table salt, which is a mixture of sodium chloride with inorganic iodine compounds and which is used for elimination of iodine deficiency in the human diet. The disadvantage of it is the difficulty of ensuring normalized iodine intake due to the technological difficulties of making quality of iodized salt and the individual variability of consumption. On the background of the consumption of such salt marked increase in the number of diseases hyperthyroidism. Mineral iodine compounds - potassium Iodate and potassium iodide used for salt iodization and other food products, in natural conditions act as a secondary source of iodine. Evolutionary present the mechanism of iodine metabolism in the first place directed to the use of organic forms of iodine, predominant in natural foods (e.g., seaweed).

Known use as a source of iodine iodine with organic media, therefore, these substances behave in the body as a source of the mineral iodine.

Well-known drug for the prevention and treatment of diseases of the thyroid gland, which is an organic compound with covalently bound iodine is iodized protein thyroidin. However, thyroidin has hormonal activity. The hormonal drugs should be under strict medical supervision with regard to comorbidities. Incorrect dosage leads to serious complications. The use of thyroidin as the source of iodine is unacceptable because it leads to replacement of the native hormones on coming from outside. In response, the thyroid gland reduces its physiological activity is diminished in sizes up to atrophy. Further still, the drug overdose may cause induced hyperthyroidism (Great medical encyclopedia, M., Soviet encyclopedia, 1963, S. 202-203).

The closest analogue to the invention is a biologically active food Supplement for the prevention of iodine deficiency, contains organic iodine-containing substance, and a food product containing the biologically active additive (PA is efficiency, their unsuitability for adequate exposure to the organism in order to reduce or eliminate physiological and biochemical disorders of iodine metabolism.

To prevent violations of iodine metabolism in present practice: the use of compounds based on inorganic iodine and salt their food to bring its daily consumption to physiological norms; the use of organic forms of iodine, predominant in natural foods (eg, laminaria); intake of food SUPPLEMENTS based on vegetable sources of iodine, and the use of iodine-containing hormones.

The present invention is aimed not only at addressing the issue of prevention of iodine deficiency, but also to eliminate violations of iodine metabolism in General. The goal is to create food SUPPLEMENTS and food products containing the most physiological iodine-containing compounds of organic origin, is not a non-hormonal activity, an adequate biochemical peculiarities of iodine metabolism and are therefore able to provide the launch of its mechanisms of self-control and autoregulation. In this case the obtained compound should take into account the individual characteristics of yodobashi (BAA) for the prevention of iodine deficiency contains organic iodine-containing substance, according to the invention the organic iodine-containing substance is a synthetic organic compound with covalently bound iodine, selected from the group of carboxylic acids, unsaturated fatty acids, lipids, terpenes, alkanes, terpenoids, isoprene, peptides, polypeptides, amino acids, protein hydrolysates, protein hydrolysates, plant proteins, animal proteins, proteins of microbial origin, of a mixture of lipids and unsaturated fatty acids, a mixture of isoprene and terpenes mixture of isoprene and protein hydrolysates, a mixture of isoprene and unsaturated fatty acids, mixtures of proteins of plant, animal and microbial origin, of a mixture of proteins of vegetable and animal origin, a mixture of proteins of animal and microbial origin, of a mixture of proteins of plant and microbial origin, proteins, peptides, polypeptides, amino acids, polypeptide and protein hydrolysates iodine is covalently bonded in the 5 and 3 or 3-position of the phenolic cycle, and amino acids and proteins selected from the group of amino acids and proteins, not with thyroid hormone activity, and which are the conditions preventing condensation tyrelassie or whey proteins, the hemoglobins, as vegetable and soy protein, and as a microbial protein, such as, yeast proteins as hydrolyzed yeast.

Additional SUPPLEMENTS may contain organic compound with ecovalence iodine and/or inorganic iodine.

BAA can be a prolonged form. It is advisable to make in the form of tablets, powders, capsules, microcapsules, tablets, solutions. When microcapsules are produced by microencapsulation using carbohydrate, protein or lipid material.

Iodine-containing substance can be included in the composition of the inert polymer matrix, such as carrageenan, pectin, agarose or uronic acids.

BAA may be part of the vitamin-mineral complexes.

The second object of the invention is a food product that contains the above BAA in any of the above combinations.

The food product is a dairy product, milk product, meat product, bakery product, bread, beverage, juice, confectionery, baby food.

In the present invention proposed to COI the different groups of substances, on the basis of the following definitions.

Peptides are organic compounds consisting of two or more amino acid residues linked by peptide bonds, and which can also be obtained as products of incomplete hydrolysis of polypeptides or proteins. Peptides containing more than ten amino acid residues are called polypeptides (a. Leninger, fundamentals of biochemistry. M., Mir, 1985, S. 132).

Proteins of high molecular weight nitrogen-containing organic compounds represent a polypeptide chain, containing from 100 to 1000 or more amino acid units joined together by peptide bonds (ibid S. 160).

The proposed organic iodine-containing compounds included in the composition of food SUPPLEMENTS and food products that do not have hormonal activity. They contain iodine covalently bound form. This form of iodine allows the use of these substances as a source of iodine, and as the substrate, allowing to optimize iodine metabolism in General.

As it was mentioned above, the embodiment of the invention can be performed in several combinations. BAA and accordingly foods can contain, as one of the synthetic organic compounds with covalently stow, isoprene, peptides, polypeptides, amino acids, protein hydrolysates, protein hydrolysates, plant proteins, animal proteins, proteins of microbial origin, and a mixture of synthetic organic compounds with covalently bound iodine from the group: a mixture of lipids and unsaturated fatty acids, a mixture of isoprene and terpenes mixture of isoprene and protein hydrolysates, a mixture of isoprene and unsaturated fatty acids, mixtures of proteins of plant, animal and microbial origin, of a mixture of proteins of vegetable and animal origin, a mixture of proteins of animal and microbial origin, of a mixture of proteins of plant and microbial origin. This must be complied with the following condition: proteins, peptides, polypeptides, amino acids, polypeptide and protein hydrolysates iodine must be covalently bonded in the 5 - and 3-m or 3-position of the phenolic cycle, and amino acids and proteins should be selected from the group of amino acids and proteins, not with thyroid hormone activity, and which are the conditions preventing condensation of tyrosine kernels.

So if you enumerate in detail all combinations of the embodiments and/BR> peptides in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, peptides in which the iodine is covalently bonded to the 3rd position of the phenolic cycle

polypeptides in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, polypeptides, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle

polypeptide hydrolysates, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle

polypeptide hydrolysates, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle

amino acids, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, amino acids, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle, and these amino acids selected from the group of amino acids, not with thyroid hormone activity, and which are the conditions preventing condensation of tyrosine nuclei,

protein hydrolysates, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, protein hydrolysates, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle

proteins of plant origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle proteins of plant origin, the cat is giving thyroid hormone activity, and which are the conditions precluding condensation of tyrosine nuclei,

proteins of animal origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, animal proteins, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle, and these proteins selected from the group of proteins that do not have thyroid hormone activity, and which are the conditions precluding condensation of tyrosine nuclei,

proteins of microbial origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle proteins of microbial origin, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle, and these proteins selected from the group of proteins that do not have thyroid hormone activity, and which are the conditions precluding condensation of tyrosine nuclei,

a mixture of isoprene and protein hydrolysates, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, a mixture of isoprene and protein hydrolysates, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle

the mixture of proteins of plant, animal and microbial origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic who points the user in the 3rd position of the phenolic cycle, moreover, these proteins selected from the group of proteins that do not have thyroid hormone activity, and which are the conditions preventing condensation of tyrosine nuclei,

the mixture of proteins of vegetable and animal origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, the mixture of proteins of vegetable and animal origin, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle, and these proteins selected from the group of proteins that do not have thyroid hormone activity, and which are the conditions preventing condensation of tyrosine nuclei,

the mixture of proteins of animal and microbial origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, the mixture of proteins of animal and microbial origin, in which the iodine is covalently bonded to the 3rd position of the phenolic cycle, and these proteins selected from the group of proteins that do not have thyroid hormone activity, and which are the conditions preventing condensation of tyrosine nuclei,

the mixture of proteins of plant and microbial origin, in which the iodine is covalently bonded in the 5 - and 3-position of the phenolic cycle, a mixture of vegetable proteins and microbiologics is from the group of proteins, not with thyroid hormone activity, and which are the conditions precluding condensation of tyrosine kernels.

For the production of food SUPPLEMENTS and preventive food offers simple, combined and extended form of iodine-containing compounds, providing an individual approach to the prevention of diseases associated with disorders of iodine metabolism.

The epithelium of the intestine carries out differential absorption of iodine - absorption of iodide and the transmembrane transfer of organic compounds with covalently bound iodine. In the latter case, the iodine is absorbed as a single complex with organic media, without the prior release in the intestine. In the future iodide from the intestines into the blood and is stored in the thyroid gland, and the covalently linked organic iodine becomes available tissue exchange and acquires the ability to be deposited not only in the thyroid gland. The main role in the further metabolism itorganize plays the liver, where is the enzymatic cleavage of chemically bound iodine as iodide ion, which is extracted by the thyroid gland from the blood for their synthetic howl acid for their subsequent excretion in the urine or bile. Iodinated amino acids are in the liver to pereaminirovanii, decarboxylation, hydroxylation, oxidative deamination, methylation. Iodine pyruvate and acetate analogues can be excreted with urine. Thus, iodine-containing compounds implement almost all of the metabolic capabilities of iodine metabolism, and this in turn provides additional the body's ability to auto control and self-regulation of this process.

The absorption of iodine in the intestine is one of the key factors to maintain its homeostasis in the body and is a result of both physiological condition of the bowel, and functional status of the biochemical mechanisms of absorption. The proposed invention allows the directional impact on these processes, using different classes of iodine-containing drugs. For example, if the absorption of the iodine in the iodinated amino acids and unsaturated fatty acids involve different mechanisms of transmembrane transport and further tissue exchange. Because tissue dehalogenase with different efficiency perform deyodirovania variety itorganize substrate, this de is it in the bloodstream, and at the level of peripheral metabolism. It is proposed to use various forms of iodine-containing drugs, which not only provide the body with iodine, and optimize iodine currency due to the nature of their metabolism.

It is advisable to use the drug in the form of simple, combined and prolonged forms. A simple form is a synthetic organic compound non-hormonal nature, containing covalently bound iodine. Iodine-containing synthetic substances produced by ladirovannye organic compounds of different classes, such as phenolic derivative, which is tyrosine, both in free state and in the protein, amino acids histidine or amino acid residue derived terpene, terpenoid or isoprene nature, unsaturated fatty acids, alkanes, lipids, proteins or peptides, polypeptides, protein or polypeptide hydrolysates, as well as the previously mentioned mixtures of some compounds. Iodination of organic substances carry out the chemical or enzymatic means, or both, and chemical and enzymatic means, or bioengineering, using known methods (1,2,3,4 th activity, and which are the conditions preventing condensation of tyrosine kernels.

It is advisable to iodination of peptides, polypeptides, proteins on tyrosinase or his-tag amino acid residues or simultaneously tyrosinosis and his-tag amino acid residues. It is advisable to obtain a synthetic organic substance with covalently bound iodine hydrolysis pre-iodinated proteins or polypeptides.

Useful as an organic substance covalently bound iodine iodized unsaturated fatty acid in free or chemically bound state or in a combination of free fatty acids and their chemical compounds.

It is useful to produce a combined form of iodine-containing SUPPLEMENTS, which is a combination of organic iodine in the form covalent and organic iodine in a non-covalent manner, as well as organic iodine in the form covalent inorganic iodine. These SUPPLEMENTS provide for the involvement of alternative mechanisms of absorption of iodine and is required when violations of iodine currency at this stage.

It is advisable to use a prolonged form of iodine-containing substances - sintet the matrix, with the three-dimensional structure of the molecular sieve or the composition of the microcapsules (microspheres) of protein, lipid or carbohydrate nature. Polymer matrix or microcapsule (microsphere) provides steric hindrance to exit iodargyrite, prolonging this process, and hence the suction process. Steric hindrance for proteolysis included in the polymer iodinated proteins or peptides also prolong the release of iodine-containing amino acids and their absorption. Prolonged form of iodine-containing SUPPLEMENTS can be represented by a combination of iodine-containing compounds of different nature - a combination of inorganic covalently and ecovalence bound iodine in organic compounds. To obtain the polymer matrix can be used agarose, pectin, alginic acid, carrageenan, uronic acid. For the purpose of prolongation of the microcapsules obtained by microencapsulation using carbohydrate, protein or lipid material. This prolonged form of iodine-containing substances may represent a previously specified a mixture of synthetic iodine-containing substances of different chemical nature.

Consumption of all forms of the iodine-containing the definition and age boundaries and norms. Introduction synthetic covalently linked iodinated organic compounds in the human body is composed of biologically active food supplements in different forms of vitamin-mineral complexes and various food products. Fortification of food are using iodargyrite in dry form or in the form of a solution.

Synthetic organic compounds containing covalently bound iodine, have chemical stability, thermal, lightfastness, good solubility in water or organic solvents. Physico-chemical properties of these compounds make them useful for the enrichment of a wide range of food products - milk and milk, meat, bread and bakery, confectionery, drinks, juices, baby food, etc.

Because the proposed methods iodization and selected for this organic substances of different chemical nature provide a high degree of iodization, the thus obtained iodine-containing substances are used in the micro-and thus their impact on the organoleptic properties of the fortified product.

The technical result izobretatelskikh means for violations of iodine metabolism, the possibility of optimizing iodine exchange with consideration of the peculiarities of the metabolism of iodine-containing compounds in the human body, providing an individual approach to the prevention of violations of iodine metabolism through targeted regulation of this process. Introduction as a source of iodine synthetic organic substances containing iodine covalently bound form in an organism in the form of SUPPLEMENTS or fortified foods ensures the absorption of iodine as a whole with organic media without prior removal in the gastrointestinal tract of free iodine and iodide. Non-hormonal organic iodine compounds are exposed to a variety of metabolic transformations characteristic of iodine metabolism. Released by enzymatic catalysis ion iodide enters the thyroid gland. Iodinated synthetic organic compounds of different chemical nature, such as unsaturated fatty acids, amino acids, alkanes, lipids, compounds isoprene or terpene nature imbibed with different efficiency through specific transmembrane transport systems. The choice of nature iodized synthetic organic is the General process of tissue enzymatic release of iodine from its composition, on the basis of differences in substrate specificity varied iodine-containing chemicals, the extent of their availability enzymatic catalysis in the specific tissue deposition of various representatives iodargyrite. Biochemical characteristics of the iodine metabolism of organic substances, represented by compounds of different chemical nature, provides an opportunity to modulate the intensity of the individual chemical reactions that affect the level of renal or intestinal excretion of iodine-containing metabolites. Exposure to iodine-containing synthetic organic compounds of various metabolic transformations and processes enables the optimization of iodine metabolism without causing spikes in the concentrations of iodine in the blood plasma, as well as considering the individual physiological and biochemical characteristics of the organism. Using as a source of iodine his covalently linked organic form, it became possible to run the mechanisms of autoregulation and self-control of iodine metabolism in the human body.

The invention is illustrated by the following examples, which, however, do not cover, and moreover does not restrict the entire amount of the claims of this invention.

Cow's milk degrease and release casein protein fraction. Received the casein is dissolved, the solution is placed in a thermostatted reactor, equipped with peremeshivajutsa device. For iodization use of elemental iodine - crystalline and soluble. During the reactions is any clear of inorganic forms of iodine. Iodide is removed by presidenial protein using centrifugation and ultrafiltration. The iodization process provides a highly effective antiseptic treatment of a solution of milk protein.

Purified iodinated proteins can sucrose (50%) or glycerol (50%). The solution further sterilized by briefly heating to 90oC. a Solution of iodized protein - BAD - food Packed in glass jars and sealed under vacuum.

The resulting solution iodized casein is used for the enrichment of bread. The protein solution is added to the batch before making flour than is achieved uniform distribution of iodized protein in the dough and the finished product. Iodine is associated with tyrosinemia amino acid residues covalent bond. These compounds are characterised by stability. Decomposition of iodination happens when 199-201oC. Thus, the process of baking bread, despite quite a high temperature, does not affect the chemical stability of organic compounds with covalently bound iodine.

The number added to the bread iodized casein depends on the degree of endemicity in the region, the per capita norms pishetsa to free amino acids. Itirapina imbibed of the intestinal mucosa as a single chemical compound without prior release of iodine. Stimulate itirapina with blood flow available to the various body tissues, primarily the liver. In cells itirapina are exposed to a variety of biochemical transformations. Enzymatic deyodirovania releases free iodide, which is available synthetic processes in the thyroid gland. The dynamics of the receipt of iodide in the blood and the thyroid gland when used as the source of its organic iodine covalently bound form is fundamentally different from that in the original iodine intake in the form of inorganic compounds. Itirapina can desaminase, decarboxylase, to oxidize on the tyrosine ring, conjugates with glucosideuronic or sulphate groups. The resulting conjugates can be extracted from the bile. Iodinated metabolites can be excreted from the body with urine.

Thus, iodine-containing amino acids covalently bound iodine are not the only source of iodine, but also provide self-regulation of iodine metabolism in the body, since are available for various biochemical the connections. Iodized casein as on the chemical nature of iodine-containing compounds, and the nature of their metabolism, are analogues of natural iodine compounds - the main source of iodine for the body.

Example 2. Food SUPPLEMENTS as a source of iodine contains iodinated by soy protein tyrosine together with elemental iodine iodized starch. Iodine from such a combined BAA enters the body differentially in covalently linked with the amino acid form and in the form of inorganic iodine. Despite the high degree of Association of iodine with starch, the latter releases a limited amount of iodine in the dissociation. Recovered to iodide iodine enters the blood. Thus, the combined form BAA employ alternative mechanisms of absorption and metabolism of iodine. This form SUPPLEMENTS provides faster iodine in the thyroid gland.

Example 3. BAA receive in the form of a combined preparation comprising potassium Iodate - inorganic iodine compound and organic covalently linked form of iodine is iodized at tyrosine and histidine egg albumin. BAA provides the enable alternate the banking stability.

Example 4. BAA made from hydrolysates iodized food protein hemoglobin, which is included in a gelatin capsule. As a stabilizer is used hyaluronic acid. The capsule has a prolonged action. The drug is soft, has no effect on the mucous membrane. Capsules are convenient to take, they are small in size, have no taste and smell.

Example 5. Cook fat-soluble food SUPPLEMENTS in the form of a mixture of iodized unsaturated fatty acids - linoleic, arachidonic, linoleic and iodized isoprene - carotenes and lycopene. This form SUPPLEMENTS are suitable for the enrichment of iodine-rich fat food. This Supplement has a prolonged action, as imbibing, such as fatty acid in lymph it is stored in fat depots. Iodine of these compounds released by enzymatic catalysis. The advantages of such SUPPLEMENTS is that you can enter large doses covalently bound iodine, excluding one-time release of free iodide in large quantities.

Example 6. BAA on the basis of a mixture of iodized protein hydrolysates obtained from iodized egg albumin, and iodized isoprene - Karoti the es biochemical effect of vitamin-mineral complex. Normalized consumption of iodine is consistent with accepted standards.

Example 7. BAA prolonged action is part of the vitamin-mineral complex. It is made in pill form from a polymeric matrix consisting of alginic acid. In the solution of alginic acid make iodized milk whey protein, a mixture of vitamins and minerals. A solution of alginate polymerizes making solution of calcium chloride, molded and dried. In the gastrointestinal tract polymer matrix of alginate creates a physical barrier to enzymatic hydrolysis for enzymatic hydrolysis iodized protein and release of iodine-containing amino acids. Polymer matrix prolong the absorption of iodine in the gut.

Example 8. As BAA use iodinated amino acids monoiodotyrosine and diyodtirosin. They are of a very high content of iodine is 41.4% and 58.7%, respectively. This degree of iodization, despite the limited solubility of these compounds in water, can effectively use them to enrich drinks. Small molecules of iodine-containing contrast agents provide effective sterilization iodised is p casein goat's milk containing iodine covalently bound form, by analogy with natural female milk. Such a BAD fit for enrichment mixtures like "baby" and "Baby". This is facilitated by a high degree of iodination of the protein and, therefore, negligible amount of SUPPLEMENTS needed to enrich mixtures, as well as high thermal stability of covalent compounds of iodine, good solubility and low allergenicity. Technology of production of iodized infant formula comprises introducing cow's milk iodized protein, homogenization of dairy bases, vacuum concentration and spray drying.

The efficiency of the use of synthetic iodized milk proteins as a source of iodine for infants obvious, since the only form of iodine in natural breastfeeding advocate its covalent compounds with proteins of milk.

Example 10. BAA - iodinated peptides receive partial enzymatic hydrolysis of pre-iodized casein. This BUD has a high resistance in the technological processes of production of baby food or baking bread. In the production of bread yodsoderjasim evenly distributed in bread loaf, that provides normalized iodine intake.

Example 11. Enrichment of meat products compounds with covalently bound iodine for the prevention of iodine metabolism in the population carried out by saturating the meat iodinated soy protein. Synthetic iodinated protein can withstand heat treatment in the composition of the meat product, such as sausage. The temperature of thermal decomposition of iodized tyrosine - 199-201oC.

Example 12. BAA on the basis of iodized dairy whey proteins suitable for the enrichment of iodine in milk and milk products. BAD it is advisable to enter before pasteurization of milk basis. The use of dietary SUPPLEMENTS in amounts exclude its influence on the organoleptic properties of dairy products.

Example 13. Food SUPPLEMENTS in the form of pellets on the basis of iodinated polypeptides produced by ladirovannye polypeptides, which are formed by removing heme from hemoglobin.

Example 14. Fat-soluble food SUPPLEMENTS for prevention of iodine deficiency is obtained on the basis of iodized isoprene - carotene. Such SUPPLEMENTS include vitamin complex containing lipids.

Use the>2. Hager L. P. "Iodination of Tyrozine by Chloroperoxidase", In "Methods in Enzymology", v.XVII, Part A, Acad. Press, N. Y., London, 1970.

3. Morrison M. "Iodination of Tyrozine: Isolation of Lactoperoxidase", In "Methods in Enzymology", v.XVII, Part A, Acad. Press, N. Y., London, 1970.

4. Missouri. Agric. Exp. Stat., Research Bull, v.355, 1942.

5. Hunter W. M., Greenwood F. C., Nature, London, V. 194, 1962, p.495.

1. Biologically active additives (BAA) to food for the prevention of iodine deficiency, contains organic iodine-containing substance, characterized in that the organic iodine-containing substance is a synthetic organic compound with covalently bound iodine selected from carboxylic acids, unsaturated fatty acids, lipids, terpenes, alkanes, terpenoids, isoprene, peptides, polypeptides, amino acids, protein hydrolysates, protein hydrolysates, plant proteins, animal proteins, proteins of microbial origin, of a mixture of lipids and unsaturated fatty acids, a mixture of isoprene and terpenes mixture of isoprene and protein hydrolysates, a mixture of isoprene and unsaturated fatty acids, mixtures of proteins of plant, animal and microbial origin, of a mixture of proteins of vegetable and animal origin, a mixture of proteins of animal and microbial origin, smokecloak, polypeptide and protein hydrolysates iodine is covalently bonded in the 5 - and 3 - or 3-position of the phenolic cycle, and amino acids and proteins selected from the group of amino acids and proteins, not with thyroid hormone activity, which are conditions preventing condensation of tyrosine kernels.

2. BAA under item 1, characterized in that the protein quality of animal use casein, egg albumin, milk or whey proteins, hemoglobins, and quality of vegetable protein is soy protein.

3. BAA under item 1 or 2, characterized in that it further contains an organic compound with ecovalence iodine.

4. BAA according to any one of paragraphs. 1-3, characterized in that it further contains inorganic iodine.

5. BAA according to any one of paragraphs. 1-4, characterized in that it is a prolonged form.

6. BAA according to any one of paragraphs. 1-5, characterized in that it is carried out in the form of tablets, powders, capsules, microcapsules, tablets, solutions.

7. BAA under item 6, characterized in that the microcapsules obtained by microencapsulation using carbohydrate, protein or lipid cyrilleroy matrix, for example, carrageenan, pectin, agarose or uronic acids.

9. BAA according to any one of paragraphs. 1-8, characterized in that it is part of the vitamin-mineral complexes.

10. Food product containing BAA, characterized in that as BAA it contains BAA on PP. 1-9.

11. Food product under item 10, characterized in that it is a dairy product.

12. Food product under item 10, characterized in that it is a milk product.

13. Food product under item 10, characterized in that it is a meat product.

14. Food product under item 10, characterized in that it is a bakery product.

15. Food product under item 10, characterized in that it is a bread.

16. Food product under item 10, characterized in that it is a drink.

17. Food product under item 10, characterized in that it is a juice.

18. Food product under item 10, characterized in that it is a confection.

19. Food product under item 10, characterized in that it is the product of baby food.

 

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