(C07C47/225)

Novel aldehydes and nitriles, obtained from isophorone, and application thereof in perfumery // 2535784
FIELD: chemistry.SUBSTANCE: invention relates to novel compounds of formula (I), which can be applied as an aromatic compound or a smell-masking agent. In formula (I) R stands for a hydrogen atom, C1-C6 alkyl, C2-C6 alkenyl or =CH2; Z stands for CN or CHO; and there is not more than one dashed bond. The following conditions must be observed: if Z stands for CHO and there is one of the dashed bonds, R does not stand for a hydrogen atom, and if there is a dashed bond between carbons Ca and Cb, R does not stand for a group = CH2. The invention also relates to a method of obtaining a formula (I) compound, its application as the aromatic compound or the smell-masking agent, and a perfumery composition.EFFECT: increased activity of the composition application.10 cl, 1 tbl, 10 ex

Use of campholene derivatives as aromatic ingredients in perfumery and manufacturing // 2458048
FIELD: chemistry.SUBSTANCE: invention relates to campholene derivatives of general formula (I), a fragrant or aromatic flavouring composition and use thereof in perfumery to obtain perfumed bases and concentrates, as aromatic agents for producing flavouring compositions or products, as agents which mask smell and/or taste, including in a combination with other perfumery or aromatic ingredients, solvents and additives. In general formula (I) , R1, R2, R3, R4 and R5 each independently denote a hydrogen atom or a linear or branched C1-C5 alkyl or C2-C5 alkenyl group, - Y denotes CN, C(O)R6 or a CR6(ORα)(ORβ) group, where R6 denotes a hydrogen atom or a linear or branched C1-C5 alkyl or C2-C5 alkenyl group, and Rα and Rβ simultaneously denote a linear or branched C1, C2, C3, C4 or C5 alkyl or C2, C3, C4 or C5 alkenyl group, the - 5-member ring is saturated or contains a double bond between C3' and C4' in formula (I), and the side chain, if necessary, contains a double bond between C1 and C2 and/or between C3 and C4, under the condition that said derivative is not 3-methyl-6-(2,2,3-trimethyl-cyclopent-3-enyl)-hex-4-enal.EFFECT: use of campholene derivatives to obtain perfumed bases and concentrates.10 cl, 1 tbl, 2 dwg, 20 ex

Synthesis and use of (-)-beta-elemene and (-)-beta-elemenal // 2445305
FIELD: chemistry.SUBSTANCE: present invention relates to a method of producing (-)-beta-elemenal, use of (-)-beta-elemenal as an antitumour agent, as well as to a pharmaceutical composition and a medicinal agent based on said compound. The method involves reaction of a mixture of isomeric beta-elemenols (2:1) with c MnO2, activated in a vacuum at 150°C as a catalyst. The initial mixture of isomeric beta-elemenols (2:1) is obtained by reacting a mixture of diastereomeric epoxides (2:1) with diisopropylamine in the presence of n-BuLi.EFFECT: higher efficiency. 4 cl, 21 tbl, 9 dwg, 36 ex

ethod of producing 11-cis-retinal isomer // 2417983
FIELD: chemistry.SUBSTANCE: method involves Wittig olefination of the 6E-isomer of 2E-2,6-dimethyl-8-triphenylsilyloxyocta-2,6-dien-4-yn-1-al (synthon C10)ylid, generated in situ from β-cyclogeranyltriphenyl phosphonium halide, removal of triphenylsilyl protection in the obtained silylated 13E-isomer of 11,12-didehydroretinol. After removal triphenylsilyl protection, the obtained 13E-isomer of 11,12-didehydroretinol is oxidised to 11,12-didehydroaldehyde using MnO2 without extracting the semi-product separately and further purification procedures, and stereo-specific reduction of the triple bond in 11,12-didehydroaldehyde is then carried out in via hydrogenation on a Lindlar catalyst to obtain the desired 11-cis-retinal isomer, where generation of ylide from β-cyclogeranyltriphenyl phosphonium halide is carried out under the following conditions: a) NaH in tetrahydrofuran at 0-5°C, b) anhydrous K2CO3 in dichloromethane, in the presence of interphase transfer catalysts - quaternary ammonium salts at 20-25°C, or c) 1,2-epoxybutane in dichloromethane at 50-60°C.EFFECT: obtaining medicinal agents for preventing or therapy of severe pathologies of the human optical system.2 cl, 1 dwg, 1 tbl, 5 ex

Campholene aldehyde synthesis method // 2402522
FIELD: chemistry.SUBSTANCE: invention relates to a method for synthesis of campholene aldehyde which is widely used in perfumery and household chemicals. The method involves conversion of α-pinene epoxide in a supercritical complex solvent consisting of a mixture of carbon dioxide, propanol-2 and water at temperature of 160-240°C and pressure of 130-220 atm. As a rule, the conversion reaction is carried out in a supercritical solvent with molar ratio water/α-pinene epoxide equal to 5-7.9.EFFECT: method increases rate and efficiency of the chemical process to obtain an end product with high output and with controlled selectivity.2 cl, 1 tbl, 6 ex
 
2551390.
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