Containing hydroxy groups (C07C47/19)

C   Chemistry; metallurgy(318876)
C07   Organic chemistry(61593)
C07C47        Compounds having ; cho groups(815)
C07C47/19                     Containing hydroxy groups(23)
Synthetic intermediate compound 1-(2-desoxy-2-fluoro-4-thio-β-d-arabinofuranosyl)cytosine, synthetic intermediate thionucleosides compound and method for their production // 2633355
FIELD: pharmacology.SUBSTANCE: invention relates to a process for preparation of a compound of the formula and also to a process for the preparation of 1-(2-desoxy-2-halo-4-thio-β-D-arabinofuranosyl) cytosine of the following formula: . In addition, the invention relates to a formula intermediate.EFFECT: new method for preparation of thionucleoside, which is useful as a medicament, is developed.24 cl, 48 ex

ethod of producing high-purity polyethylene glycol-aldehyde derivatives // 2463317
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing high-purity polyethylene glycol-aldehyde compounds of general formula OHC-(CH2)k-1-O-(CH2CH2O)n-(CH2)k-1CHO. The method of producing said compounds is realised by reacting a polyethylene glycol derivative of formula: HO-(CH2)k-O-(CH2CH2O)n-(CH2)k-OH, with dimethylsulphoxide and dicyclohexylcarbodiimide.EFFECT: method of producing polyethylene glycol-aldehyde compounds is cheap and said compounds can be used to improve solubility and efficiency of medicinal substances owing to binding thereto without impurities.11 cl, 3 ex

ethod of producing glycol aldehyde // 2371429
FIELD: chemistry.SUBSTANCE: present invention relates to a method of producing glycol aldehyde, involving reaction of formaldehyde with hydrogen and carbon monoxide in the presence of a catalyst composition, which is based on a) rhodium source, b) ligand with general formula R1P-R2 (I), where R1 is a bivalent radical, which, together with the phosphorous atom to which it is bonded, is 2-phospha-1,3,5,7-tetraC1-20alkyl-6,9,10-trioxatricyclo[{3,7}]decile group, and where R2 is a monovalent radical, which is chosen from an alkyl group, containing 4 to 34 carbon atoms or a radical with general formula: -R3-C(O)NR4R5 (II), where R3 represents methylene, ethylene, propylene or butylene, and R4 and R5 independently represent an alkyl group containing 1 to 22 carbon atoms, and c) anion source. The invention also relates to a catalyst composition used in the production of glycol aldehyde, and to a method of producing ethylene glycol from glycol aldehyde obtained using the described method.EFFECT: easy conversion of formaldehyde to glycol aldehyde in the presence of a stable catalyst.6 cl, 11 ex

ethod for preparing glyoxal-containing products // 2321577
FIELD: chemical technology.SUBSTANCE: invention relates to a method for continuous synthesis of glyoxal-containing products of the desired concentration in a single-step technological cycle. Method involves vapor-phase catalytic process of partial oxidative dehydrogenation of ethylene glycol with oxygen diluted with steam and nitrogen in the mole ratio from 1/6.5 to 1/13.0 at temperature 400-700°C on carrier Ag-contacts and massive Ag-catalysts made of materials of electrolytic origin of particles size 0.1-4.0 mm. Then the process involves continuous the vat-less separation of vapor-gaseous oxidate for liquid fractions and gaseous phase wherein prepared aqueous aldehyde solutions contain 4-40% of glyoxal, 6.2% of glycolic aldehyde, not above, 4.6% of formaldehyde, not above, 4.0% of ethylene glycol, not above, at the total acidity index 2%. The end product comprises 39.8% of glyoxal, 5.5% of glycolic aldehyde and 0.4% of formaldehyde. The process of continuous the vat-less separation of synthesis products for glyoxal-containing liquid fractions and depleted gaseous phase is carried out continuously in the range of temperature 10-400°C as result of subcontact cooling in combination with three-step combined condensation of components of vapor-gaseous oxidate in a cascade block-unit in fractional isolation of liquid and gaseous products of synthesis, and in regulation of heat regimen of the combined condensation and change of the ratio of liquid fractions.EFFECT: improved method of synthesis.1 dwg, 13 ex

Derivatives of polyetylene glycol aldehyde // 2288212
FIELD: organic chemistry, chemical technology.SUBSTANCE: invention relates to compounds of polyethylene glycol aldehyde (PEG-aldehydes), to method for synthesis of indicated compounds of polyethylene aldehyde, and to intermediate compounds that are used in synthesis of PEG-aldehydes. Method for synthesis of PEG-aldehydes involves pyrolysis of indicated intermediate substances. Indicated aldehydes of polyethylene glycols represent specific reagents for formation of PEG-peptides and other biomolecules by N-terminal amino acid residues, i. e. PEG-aldehydes form conjugate with N-terminal α-amino-group of biomolecule or protein with formation of a stable bond as secondary amine between PEG and biomolecule or protein. Also, in PEG-polypeptides the specific N-terminal bond is formed that excludes formation of cross-linking bonds or formation of some derivatives of the same polypeptide. Depending on chosen aldehyde PEG can bind covalently with biomolecule by one terminal group (monofunctional PEG-aldehyde) or by two terminal groups (bifunctional PEG-aldehyde). The advantage of PEG conjugates with biomolecules involves their enhanced retaining and delayed metabolism in body.EFFECT: improved preparing method, improved and valuable properties of compounds.17 cl, 7 ex

The method of obtaining 1,3-alkanediols and 3-hydroxyaldehyde // 2149156
The invention relates to a method for producing 1,3-alkanediols and 3-hydroxyaldehyde through hydroformylation of oxirane (1,2-epoxide)