Containing hydroxy or o-metal groups (C07C43/23)

ethod for alcoxyphenol and alcoxyhydroxybenzaldehyde production // 2628525
FIELD: chemistry.SUBSTANCE: method for alkoxyphenol production comprises O-alkylation of at least one hydroxyphenol to form at least one alkoxyphenol, at that, the said reaction is carried out using an O-alkylating agent, an aqueous solvent containing a Bronsted base and an organic solvent with a base/O-alkylating agent ration in the range of 0.5 to 1.5 moles of base per mole of O-alkylating agent, with an O-alkylating agent/hydroxyphenol ratio in the range of 0.5 to 2 moles of O-alkylating agent per mole of hydroxyphenol and with an organic solvent/hydroxyphenol ratio of less than 280 ml, preferably in the range of 10 to 250 ml and more preferably in the range of 50 to 150 ml of an organic solvent per mole of hydroxyphenol. One of the versions of the alkoxyhydroxybenzaldehyde production method comprises preparation of alkoxyphenol from hydroxyphenol by the foregoing method and a reaction of the aldehyde group addition to the resulting alkoxyphenol to obtain the corresponding alkoxyhydroxybenzaldehyde, preferably by condensation reaction between alkoxyphenol and glyoxylic acid, followed by oxidation of the resulting compound.EFFECT: proposed method for alkoxyphenol production allows the desired product to be obtained in good yield and high purity with high conversion of initial hydroxyphenol.11 cl, 3 dwg, 7 ex

Family of aryl, heteroaryl, o-aryl and o-heteroaryl carbasugars // 2603769
FIELD: pharmaceutics.SUBSTANCE: present invention relates to a compound and its pharmaceutically or cosmetically acceptable salts, used as an inhibitor of sodium-dependent glucose co-transporter, antioxidant and for depigmenting the skin in medicine and cosmetology, of the following formula (I): , as well as methods of its production and compositions based thereon, where n, m and p are independently 0 or 1, R denotes CH2OH or CH2OR11,R1 and R2 are OH or OR15, R3 is OH or OR18, R4 is a hydrogen atom, when n=1, or a hydrogen atom, a halogen atom or OH group, when n=0; X1 is a hydrogen atom, halogen atom, OH group, (C1-C6)-alkyl or OR24; U, V and W denote phenyl, pyrazolyl, N-(C1-C6)alkyl-pyrazolyl or thienyl optionally substituted by one or more substitutes selected from a halogen atom, OH, (C1-C6)-alkyl and OR24; R11, R15 and R18 are aryl-(C1-C6)-alkyl and R24 is (C1-C6)-alkyl or aryl-(C1-C6)-alkyl. In the proposed methods a compound of formula (II) is fluoridated, or compounds of formulae (VIII) and (XI) , are bound, wherein OH group in position of R4 in the binding product of formula (I) is optionally substituted by halogen, or the compound of formula (I) is bromated with subsequent reconstruction, or a compound of formula (XVI) is associated with a compound of formula (V), where R, R1, R2, R3, X1, U, V, W, n, m and p are given above, A1 is -Li or -Mg-Hal, Hal is a halogen atom, R9 is a leaving group.EFFECT: new agent is disclosed which is suitable for bleaching and depigmentation of skin, as an antioxidant, for inhibition of sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, and diseases, where such inhibition is effective, in particular in the treatment or prevention of diabetes and diabetes-related complications.21 cl, 69 ex, 11 dwg

eans or controlling reactivity and gel time of resin mixture, reaction mixture containing thereof and its application // 2597701
FIELD: chemistry.SUBSTANCE: present invention relates to use of a new combination of a compound of formula (I) and a compound of formula (II) in the molar ratio of 1:1 to 1:10 for adjusting the reactivity and gel time of the resin mixtures based on free-radically polymerizable compounds. Compounds of formula (I) and (II) correspond to the general formulas in which R1 and R2 are each case independently hydrogen, a straight or branched C1-C8-alkyl group, and X is -OR3 o r-NR3 2, wherein R3 is a straight or branched C1-C8-alkyl group, R is a straight C1-C4-alkyl group or is -OR3, wherein R3 is a straight C1-C4-alkyl group, R′ is a branched C3-C4-alkyl group, and R″ is a branched C3-C4-alkyl group. Combination is a mixture of 2-(dimethylamino)pyrimidin-5-ol with 2,6-di(tert.butyl)-4-metilfenol; or 2-(dimethylamino)-4,6-dimethyl-pyrimidine-5-ol with 3,5-di(tert.butyl)-4-gidroksianizol or 4,6-dimethyl-2-(oktiloksi)pyrimidin-5-ol with 2,6-di(tert.butyl)-4-metilfenol. Present invention also relates to the use of the resin mixture to make mortar comprises at least one radically polymerizable compound selected from an ethylene unsaturated compound, and the said agent (combination) to control reactivity and gel time of the resin mixtures in an amount of 100 parts per million to 2.0 wt% calculated using a radically polymerizable compound. Invention also relates to reactive construction mortar from the mixture of the said resins which also contains inorganic inert additives and a solvent selected from lower alkilketones, di(lower alkyl) - lower alkanoilamides, lower benzenes, phthalic acid ethers, paraffins and water. Said mortar is used for a two-component system for obtaining cured construction mixture. Two-component system comprises the said reactive mortar from mixture of resins as component A and a curing agent selected from organic peroxide in water, and inorganic inert filling agents as component B; those are separated from each other to inhibit reactivity, and will create cured construction mixture when mixed. Said two-component system is used for chemical fixation of anchor elements.EFFECT: reactive mortars based on the proposed combination are characterised by storage stability, exhibit a synergetic effect if gel time is adjusted and increased strength of anchorage.14 cl, 2 tbl, 7 ex

Derivatives of tris(2-hydroxyphenyl)methane, their preparation and use // 2584156
FIELD: chemistry.SUBSTANCE: invention relates to new derivatives of tris(2-hydroxyphenyl)-methane having the general formula (I), with surface-active properties, whereR are independently of one another, 0 to 4 unbranched or branched aliphatic hydrocarbon radicals having 1 to 6 carbon atoms per phenyl ring,R1 is a radical selected from the group consisting of hydrogen, hydroxyl and hydrocarbon groups having 1 to 6 carbon atoms,R2 are independently of one another, radicals of the general formula (III) -(R5-O-)n-R6-X, where n is a number from 1 to 50,and where the radicals R5 independently of one another, are selected from the group consisting of radicals R7, R8 and R9: ,where R6, X, R10 and R11 independently of one another, have the following meaning:R6 is a single bond or an alkylene group having 1 to 10 carbon atoms,X is hydrogen or a hydrophilic group, where the hydrophilic group is an acidic group or a radical which comprises at least one OH group,R10 is hydrogen or an aliphatic hydrocarbon radical having 1 to 6 carbon atoms,R11 is a group -(R5-O-)m-R6-X, where m is a number from 0 to 50,and where the total number z of all groups R5 in a radical R2 is 1 to 50 with the proviso that z is a number from 2 to 50, if at least one X is hydrogen.EFFECT: preparation of derivatives of tris(2-hydroxyphenyl)methane.14 cl, 6 dwg, 4 tbl, 6 ex

New arylated camphenes, methods for producing and using them // 2578715
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds specified in the following list: methyl-2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylate; methyl-2-(2,6-dimethoxy-4-pentylphenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylate; 2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-ene; (2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-yl)methanol; (2-(2,6-dimethoxy-4-pentylphenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-yl)methanol; 2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylic acid; 2-(2,6-dimethoxy-4-pentylphenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylic acid; 3-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-ene; 3-(2,6-dimethoxy-4-pentylphenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one; 3-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one; 3-(2,6-dimethoxy-4-pentylphenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol; and 3-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, which are bound to CB2 receptor stimulation and which are under the good influence of CB2 receptor stimulation.EFFECT: compounds are applicable for treating a condition specified in inflammation, pain, neurological or neurodegenerative disorders, hepatic diseases, cerebral injuries, atherosclerosis, disorders related to anti-fibrinogen action, inflammatory intestinal disease and nausea or any combination thereof.5 cl, 2 tbl, 8 dwg, 3 ex

Therapeutic agents based on diglycylyl ether derivatives and methods for using them // 2572596
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method for inhibiting androgen receptor (AR) activity, which involves administering a therapeutically effective amount of a compound having a structure of formula into an individual in need thereof, wherein X represents CH2F, CH2Br, CH2I, CH2OG, CH2OGOG'; X' represents CH2F, CH2Cl, CH2Br, CH2I, CH2OJ''', CH2OG, CH2OGOG' or a fragment specified in the patent claim, X'' represents CH2OG or CH2OJ'''; each of J, J', J'' and J''' represents H; each of L, L', L'', Q, Q' and Q'' represents O; each of Z, Z' and Z'' represents CH; each of R1, R2, R1', R2', G, G' and G'' represents branched or unbranched unsubstituted C1-C10 alkyl. The invention also refers to compounds of formula II, specific compounds presented in cl. 23 of the patent claim, pharmaceutical compositions, use and methods for inhibiting which involve administering the above compounds.EFFECT: diglycylyl ether derivatives inhibiting activity of androgen receptor and N-terminal domain of the androgen receptor.30 cl, 20 dwg, 5 tbl, 13 ex

ethod of producing bis(2-hydroxyphenyl)ether of oligoethylene glycol in monohydrate form // 2564257
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing bis(2-hydroxy-phenyl) ether of oligoethylene glycol in monohydrate form - an intermediate product for synthesis of symmetrical and asymmetrical dibenzo-crown-ethers, which are used as a selective extractant of cations of different metals, including radioactive metals, as well as in different areas of chemistry, engineering, biology and medicine. The method includes reacting excess pyrocatechol with dichloro-substituted oligoethylene glycol in the presence of an alkaline agent in a medium of an organic solvent while heating. As the alkaline agent sodium hydroxide is used, as the organic solvent dimethylformamide is used, and the process is carried out at 100-105°C in the presence of a catalyst - silicon oxide or a metal oxide (amphoteric or basic), preferably nano-sized.EFFECT: method enables to obtain the end products with significant simplification of the implementation of the process.7 ex

Plasmalogen compounds, pharmaceutical compositions containing them and methods of treating age-related diseases // 2546108
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new compounds of formula I, wherein R1 and R2 are identical or different and specified in an alkyl or alkenyl hydrocarbon chain; the R3 group values split by lipase are specified in the patient claim. R4 and R5 are independently hydrogen or C1-C7alkyl; R6 represents hydrogen or C1-C7alkyl; and R7 and R8 are independently hydrogen or C1-C7alkyl. The invention also refers to using compounds of formulas , which are introduced into the mammalian biological system and increase the cell concentrations of specific sn-2 substituted ethanolamine-plasmalogens.EFFECT: compounds are applicable in treating or preventing the age-related disorders associated with high membrane cholesterol, high amyloids and low plasmalogens, such as neurodegeneration, cognitive disorder, dementia, cancer, osteoporosis, bipolar disorder and vascular diseases.11 cl, 18 dwg, 7 ex
Rapid catalytic method for preparing recovered form of coenzyme q10 to be used in pharmaceutical and food compositions // 2535928
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to the chemical-pharmaceutical and food industries. What is presented is a catalytic method for synthesis of a recovered form of coenzyme Q10 (ubiquinol) which can be used for the rapid preparation of ubiquinol and various based pharmaceutical compositions and biologically active food additives possessing antioxidant and antihypoxant activity. The method for preparing ubiquinol of an oxidised form of coenzyme Q10 is based on the catalytic recovery of Q10 in the presence of a chemical reducing agent, a solvent and trace amounts of a Cu2+ copper catalyst for the pharmaceutical and food applications. In addition to the substantial reduction of the time for preparing ubiquinol, using the catalyst enables reducing the consumption of the chemical reducing agent and energy. Prepared ubiquinol can be used, e.g. for preparing various compositions, including ones in the liquid form and in the form of water-soluble powders containing inclusion complexes.EFFECT: method for the synthesis of the recovered form of coenzyme Q10 (ubiquinol).10 cl, 9 ex

Chlorophenol derivatives exhibiting herbicidal activity // 2524695
FIELD: chemistry.SUBSTANCE: invention relates to compounds of structural formula , where R1=Cl, R2, R3, R4, R5=H O-(2,3-dihydroxyprop-1-yl)-2-chlorophenol; R3=Cl, R1, R2, R4, R5=H O-(2,3-dihydroxyprop-1-yl)-4-chlorophenol; R1, R4=Cl, R2, R3, R5=H O-(2,3-dihydroxyprop-1-yl)-2,5-dichlorophenol; R1=CH3, R3=Cl, R2, R4, R5=H O-(2,3-dihydroxyprop-1-yl)-2-methyl-4-chlorophenol; R1, R3 ,R5=Cl, R2, R4=H O-(2,3-dihydroxyprop-1-yl)-2,4,6-trichlorophenol; R1, R3, R4=Cl, R2, R5=H O-(2,3-dihydroxyprop-1-yl)-2,4,5-trichlorophenol, used against weeds of the grass family.EFFECT: high activity of the compounds.2 cl, 1 tbl

Benzylphenylcyclohexane derivatives and methods of thereof application // 2505521
FIELD: chemistry.SUBSTANCE: claimed are compounds of general formula I , where values of radicals are given in description, possessing inhibiting action on sodium-dependent cotransporter of glucose SGLT. Present invention also claims pharmaceutical compositions, possessing inhibiting effect with respect to SGLT, and methods of obtaining said compounds and synthetic intermediates, as well as methods of obtaining said compounds per se or in combination with other therapeutic agents for treatment of diseases or states, subjected to impact of SGLT inhibition, for instance such disease as type 1 and 2 diabetes mellitus, hyperglucemia, diabetic complications, insulin resistance, metabolic syndrome, hyperinsulinemia, hypertension, hyperuricemia, obesity, edemas, dislipidemia, chronic heart failure and atherosclerosis.EFFECT: increasing efficiency of application of derivatives.21 cl, 23 ex, 1 tbl, 8 dwg
ethod of producing bis-2-hydroxyethyl ether of 4,4'-dioxydiphenyl-2,2-propane // 2487861
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing bis-2-hydroxethyl ether of 4,4'-dioxydiphenyl-2,2-propane, which can be used to modify polyester fibres, as well as in production of polycarbonates. The method involves reaction of 4,4'-dioxydiphenyl-2,2-propane with 2-oxo-1,3-dioxolane in an inert medium in the presence of a catalyst at temperature of 150±5°C until carbon dioxide release stops. The catalyst used is a tetramethylammonium salt of monomethyl ether of carbonic acid of formula [N(CH3)4][CO3CH3], and the end product is separated by washing with water.EFFECT: invention enables to obtain the end product with high output using a simple and environmentally safe method.4 ex, 1 tbl
ethod of producing 1,5-bis(2-hydroxyphenoxy)-3-oxapentane monohydrate // 2483055
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing 1,5-bis(2-hydroxyphenoxy)-3-oxapentane monohydrate, which is an intermediate product during synthesis of crown ethers which have complexing and solvating properties and are widely used in different fields of chemistry, engineering, biology and medicine. The method involves reaction of β,β'-dichloroethyl ether with pyrocatechol, the reaction being carried out using an excess amount of pyrocatechol in a medium of glycerol and in the presence of sodium carbonate, as well as in the current of an inert gas, at high temperature and while stirring, followed by separation of the end product. The starting pyrocatechol, which is taken in 6-10% stoichiometric excess, is first treated with sodium carbonate in glycerol medium with intense stirring and at temperature of 60-80°C, after which the formed solution is heated to 145-150°C and β,β'-dichloroethyl ether is added, stirred at the same temperature, cooled and the end product is deposited from the reaction solution using ice water and the filter cake is washed with water to neutral reaction.EFFECT: disclosed method enables to obtain the end product with high output.4 cl, 2 ex
ethod of producing bis[β-2-oxyphenoxyethyl)]oxide // 2479567
FIELD: chemistry.SUBSTANCE: invention relates to synthesis of bis-[β-(2-oxyphenoxyethyl)]oxide which can be used as a semi-product in synthesis of pharmaceutical drugs. The invention proposes the synthesis of bis-[β-(2-oxyphenoxyethyl)]oxide by reacting catechol, sodium hydroxide and bis(2-chloroethyl)ether in the presence of water using ethyl alcohol as a solvent and an N,N,N-triethylbenzylammonium chloride catalyst.EFFECT: increase in output of the desired compound of more than 51%, wherein the desired compound has purity of 97%.1 ex

Diarylalkanes as efficient inhibitors of binuclear enzymes // 2466981
FIELD: chemistry.SUBSTANCE: invention relates to novel individual diarylalkanes, to method of preventing treatment of diseases and states, associated with tyrosinases, method of preventing treatment of diseases and states, associated with overproduction or uneven distribution of melamine, method of inhibiting tyrosinase activity and method of melamine synthesis suppression, in which claimed diarylalkanes, as well as compositions for local application based on novel diarylalkanes, are applied.EFFECT: increased efficiency of composition application.30 cl, 5 tbl, 14 dwg, 18 ex

Antioxidants // 2454394
FIELD: chemistry.SUBSTANCE: present invention relates to use of compounds of formula Ia, Ib or Ic or cosmetically acceptable salts thereof as antioxidants, for preparing cosmetic compositions and for controlling pigmentation, particularly for clearing areas on the skin, to certain specific compounds of formula Ia, Ib or Ic or cosmetically acceptable salts thereof, a method of producing compounds of formula Ia, Ib or Ic, a cosmetic composition based on compounds of formula Ia, Ib or Ic and preparation method thereof or . In formulae la, lb or Ic, each of R2-R6 and R9-R13 is independently selected from H, OH, straight or branched C1-C20-alkoxy groups, straight or branched C1-C20-alkyl groups.EFFECT: obtaining compounds used as antioxidants.14 cl, 9 ex, 3 tbl, 1 dwg

ethods for production and usage of etoxicombretastatines and prodrugs based thereon // 2451664
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to new etoxicombretastatines with formula (I) possessing anti-cancer activity, to a pharmaceutical composition containing the proposed compounds as well as to methods for production of some of the proposed compounds where R is a hydroxyl group, an amino group, a phosphate group selected from among disodiumphosphate or ammonium phosphate or inner salt of phosphorylcholine, -NH(COCHR'NH)m-H where R' is hydrogen, a natural amino acid side chain or a phenyl group, while m is an integer from 1 to 3.EFFECT: production of new etoxicombretastatines possessing anti-cancer activity.5 cl, 3 tbl, 2 dwg, 13 ex
ethod of producing isobornyl phenol esters // 2448083
FIELD: chemistry.SUBSTANCE: method involves alkylation of monohydric or dihydric phenols with camphene in the presence of heterogeneous acid catalysts of sulphocationite fiban K-1 in amount of 0.1-100 wt % of the initial phenol while heating to 40-70°C for 2 hours or zeolite Z-100 in amount of 0.1-100 wt % of the initial phenol at 20°C for 48 hours, molar ratio of phenol to camphene equal to 1:1-2, respectively.EFFECT: high output of end product.1 tbl, 4 ex

Fluoroalkoxy-combretastatin derivatives, use and synthesis methods thereof // 2417216
FIELD: chemistry.SUBSTANCE: in formula I Rf is an alkyl group containing 1-2 carbon atoms, in which 1-5 hydrogen atoms are substituted with 1-5 fluorine atoms, and R is an amine group or an amine group substituted with an amino acid residue of general formula NH(COCHR'NH)-H, where R' is hydrogen, a side chain of natural amino acid which is C1-C4alkyl, possibly substituted with a hydroxy group, a hydroxyl group, disodium or an ammonium phosphate group. The invention also relates to versions of the method of producing compounds of formula I, involving the following steps: fluoroalkylation of 4-hydroxy-3-methoxybenzaldehyde or 4-hydroxybenzaldehyde in the presence of an interphase transfer catalyst, to obtain 4-fluoroalkoxy-3-methoxybenzaldehyde (V) or 4-fluoroalkoxybenzaldehyde (VII), respectively, subsequent selective demethylation (V) with lithium diphenylphosphine and a protection of a hydroxy group or nitration (VII) in the 3rd position. The obtained compounds undergo Wittig reacton using a ylide of 3,4,5-trimethoxybenzyltriphenylphosphonium and the desired product is extracted.EFFECT: obtaining novel combretastin derivatives of formula (I), having angiogenesis inhibiting activity, which can be used as anticancer and/or antiangiogenic agents.6 cl, 17 ex, 4 dwg

Therapeutic quinones // 2411229
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new polyprenylated 1,4-benzoquinones of formula 1 or formula 3 or polyprenylated 1,4-hydroquinones of formula 2 or formula 4, or to their pharmaceutically acceptable salts exhibiting anticarcinogenic activity 1, 2, 3, 4. In formulae 1-4 each of R1 and R2, irrespectively of others, can be a hydrogen radical or (C1-C6)-alkoxy-group; each of R3 and R4 irrespectively of others, can be a hydrogen radical or (C1-C6)-alkyl group; n can be equal to 2 or 3.EFFECT: provided application of new compounds and some common 1,4-benzoqunones and 1,4-hydroqunones for preparing a drug, a based pharmaceutical composition, development of a method of oncotherapy, a method of inducing AP-1-dependent or NF-kB-independent transcription activity or both activities simultaneously in a cell and a method of inducing apoptosis in a cell, as well as separating glabruquinones.21 cl, 3 tbl, 28 dwg, 26 ex

Novel cyclohexane derivative, prodrug and salt thereof and diabetes therapeutic agent containing said compounds // 2394015
FIELD: chemistry; pharmaceutics.SUBSTANCE: present invention relates to novel cyclohexane derivatives of formula (I) or their pharmaceutically acceptable salts having inhibitory effect on Na+-glucose cotranspoter (SGLT2), as well as to pharmaceutical compositions based on the said compounds and their use in preventing or treating diabetes, diabetic complications caused by hyperglycaemia or obesity. , where A is -O-; n is an equal to 0 or 1; R6 and R7 each independently represents a hydrogen atom or a C1-C6alkyl group, m is an integer selected from 1-3; Q is selected from Q1 - Q5, given in formula 2.EFFECT: obtaining novel cyclohexane derivatives or their pharmaceutically acceptable salts and preparation of a pharmaceutical composition based on the said compounds.15 cl, 19 dwg, 11 tbl, 86 ex

Novel method of 3-[5'-(3,4-bis-hydroxymethylbenzyloxy)-2'-ethyl-2-propylbiphenyl-4-yl]penta-3-ol obtainment // 2392268
FIELD: chemistry.SUBSTANCE: method involves: transformation of 1-(4-hydroxy-3-propylphenyl)propane-1-on under effect of trifluoromethane sulphone anhydrite (Tf2O) in the presence of triethylamine (NEt3) into its derivative 4-propyionyl-2-n-propylphenyl ether of trifluoromethane sulphonic acid, with further concentration by Suzuki reaction type with 2-ethyl-5-metoxyphenylboronic acid in the presence of K2CO3, PdCl2(PPh3)2 or Pd(PPh3)4 in catalytic amount, obtaining 1-(2'-ethyl-5'-metoxy-2-propylbiphenyl-4-yl)propane-1-on; demethylation of 1-(2'-ethyl-5'-metoxy-2-propylbiphenyl-4-yl)propane-1-on by heating in the absence of solvent with pyridine salt excess, obtaining 1-(2'-ethyl-5'-hydroxy-2-propylbiphenyl-4-yl)propane-1-on; transformation of 1-(2'-ethyl-5'-hydroxy-2-propylbiphenyl-4-yl)propane-1-on into 6-ethyl-4'-(1-ethyl-1-hydroxypropyl)-2'-propylbiphenyl-3-ol by reaction with ethylmagnesium bromide or ethyllithium, and condensation of 6-ethyl-4'-(1-ethyl-1-hydroxy-propyl)-2'-propylbiphenyl-3-ol with dimethyl ether of 4-bromomethylphthalic acid, with further recovery reaction by lithium borohydride in situ. Claimed method allows for obtainment of target product with high output. Also invention refers to novel 6-ethyl-4'-(1-ethyl-1-hydroxypropyl)-2'-propylbiphenyl-3-ol compound used as intermediary product in the claimed method.EFFECT: possible application in medicine.17 cl, 1 dwg, 1 ex

ethod of producing 1-phenoxy-1,2-dihydro[60]fullerene // 2385859
FIELD: chemistry.SUBSTANCE: present invention relates to a method of producing 1-phenoxy-1,2-dihydrofullerene of formula (1) which can be used as a complexing agent, sorbent, biologically active compound, as well as in making new materials with given electronic, magnetic and optical properties. The method involves reacting fullerene C60 with phenol in the presence of a hafnocene dichloride catalyst in molar ratio C60: Ph-OH:Cp2HfCl2 equal to 0.01:(5-10):(0.0015-0.0025), in a toluene medium as a solvent at temperature 130-180°C for 5-7 hours.EFFECT: method enables selective production of the end product with output of 63-88%.1 tbl, 1 ex

Hexafluoroisopropanol-substituted ether derivatives // 2383524
FIELD: chemistry.SUBSTANCE: invention relates to novel hexafluoroisopropanol-substituted ether derivatives of formula (I) to their pharmaceutically acceptable salts and to esters which are capable of bonding with LXR-alpha and/or LXR-beta, as well as to pharmaceutical compositions based on said compounds. In formula (I) R1 is hydrogen, lower alkyl or halogen, one of groups R2 and R3 is hydrogen, lower alkyl or halogen, and the second of groups R2 and R3 is -O-CHR4-(CH2)m-(CHR5)n-R6. Values of R4, R5, R6 m and n are given in the formula of invention.EFFECT: novel compounds have useful biological properties.22 cl, 4 dwg, 102 ex

Vitamin d analogues // 2364584
FIELD: chemistry.SUBSTANCE: described are biaromatic analogues of vitamin D of general formula (I) , in which- A-Q is -CH2-O; - B-T is -CH2-CH2-; R1 and R2, which are identical or different, are hydrogen atom, linear or branched alkyl radical with 1-5 carbon atoms; R3 is linear or branched alkyl radical with 1-5 carbon atoms; groups R4 are identical and are hydrogen atom. Compounds of formula (I) demonstrate noticeable biological activity.EFFECT: application for obtaining pharmacological compositions; pharmacological composition; cosmetic composition for body or hair hygiene, as well as application of pharmacological composition for prevention of age-related skin aging or skin aging induced by sun irradiation.14 cl, 3 tbl, 8 ex

Water system, containing supramolecular calixarene nano-container and method of its receiving // 2362761
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology field, particularly to water system, containing supramolecular calixarene nano-container for solubilisation of active ingredients. Additionally in the capacity of calixarenes there are used joining of common formula where R=tret-butyl, iso-nonyl, n=4, 6, 8, 9, 10, 12, 16, 20, at concentration of specified calixarenes 1·10-6-1·10-1 mole/l. Furthermore, invention relates to method of receiving of proposed water system, including blending of calixarenes with water at concentration 1·10-6-1·10-1 mole/l, at room temperature. Declared water system with dimension of nano-containers from 4 up to 195 nm is able to solubilizate active ingredients - medical products, amino acids, dye and pesticides.EFFECT: providing the ability to solubilizate active ingredients - medical products, amino acids, dye and pesticides.4 cl, 2 tbl, 6 ex

ethod of obtaining adamantylphenyl ethers // 2346927
FIELD: chemistry.SUBSTANCE: invention concerns method of obtaining adamantylphenyl ethers of the general formula: R1=R2=H, R3=CH3 (1); R1=OH, R2=R3=H (2); R1=R3=H, R2=OH (3); R1=R2=H, R3=OH (4); R1=R2=H, R3=NO2 (5); R1=OCH3 R2=H,R3=C2H5 (6), which are semiproducts for bioactive substance synthesis. Method involves interaction of adamantane derivative with phenol derivative. 1,3-dehydroadamantane is used as adamantane derivative, and compounds from the range of n-cresol, pyrocatechin, resorcin, hydroquinone, n-nitrophenol, 4-ethylguaiacol are used as phenol derivative, at component mol ratio of 1:(1.5-2) in diethyl ether medium at its boiling temperature for 20-30 minutes.EFFECT: high output of adamantylphenyl ethers.6 ex

ethod of obtaining aryl ethers // 2330012
FIELD: chemistry.SUBSTANCE: invention relates to the method of obtaining the compound of the formula (IV) , which includes the epoxidation of the compound of the formula (I) the agent of oxidation in the presence of optically active compound with the formation of the compound of formula (II) , adding the gent to break the reaction, in order to extinguish any surplus oxidising agent present, where the agents for breaking the reaction are tri(C1-C6)alkylphosphite; without the isolation of the compound of the formula (II), the interaction of the reaction mixture, which includes the compound of the formula (III) in the presence of the base and the cleaning of the compound of the formula (IV) by crystallisation. The invention also relates to the method of obtaining the compound of the formula (IX) , which includes the reaction of the compound of formula (IV) with a silylation agent with the formation of a compound of the formula (V) ; the reaction of the compound of formula (V) with the silylation agent of the formula R'SO2X, where R' represents the remainder of sulfonic acid (C1-C6) alkyl and the X represents the detached group, with the obtaining of the compound of formula (VII) ; the substitution of the sulphonyloxy-group with the obtaining of the compound of the formula (VIII) and reaction of the compound of the formula (VIII) with ammonia or a compound of ammonia obtaining a compound of the formula (IX). The invention also relates to the intermediate compounds (V) and (VI) The compound of the formula (IX) can be used for obtaining a biologically active material - (S, S) - reboxetin. . In the given structural formulas pit independently are equal to 0 or a whole number from 1 up to 5; each of the groups R and R1, which can be identical or different, represents C1-C6 alkoxy or C1-C6 alkyl; P represents the protective group; R' represents the remainder of sulfonic acid (C1-C6) alkyl.EFFECT: obtaining aril ethers.14 cl, 5 ex

Analogs of vitamin d // 2301794
FIELD: organic chemistry, vitamins.SUBSTANCE: invention relates to novel triaromatic compounds, namely, analogs of vitamin D of the general formula (I): wherein values R1, R2, R3, X and Y are given in claim 1 of the invention claim. Also, invention relates to using these compounds in pharmaceutical compositions designated for treatment of the following diseases: (1) dermatological diseases associated with differentiation disturbance or proliferation of keratinocytes or sebocytes; (2) keratinization disorders; (3) dermatological diseases associated with disturbance of keratinization with inflammatory and/or immunoallergic components; (4) inflammatory diseases that don't represent keratinization disturbance; (5) cutaneous or epidermic expansion; (6) dermatological disorders, for example, vesicle dermatosis and collagenosis; (7) photoinduced or senile skin ageing, or for decreasing photoinduced pigmentations and keratosis, or any other pathologies associated with senile or photoinduced ageing; (8) skin healing and scar disturbances; (9) lipid function disturbances, such as acne hypersteatosis, simple seborrhea or seborrheic eczema; (10) dermatological diseases with immunologic component. Also, invention relates to cosmetic using the cosmetic composition for body and hair hygiene.EFFECT: valuable medicinal and cosmetic properties of compounds.16 cl, 3 tbl, 7 dwg, 10 ex

Non-nucleoside reverse transcriptase inhibitors, pharmaceutical composition comprising thereof, their using in preparing medicinal agent for treatment of hiv-1, intermediate compounds for their preparing // 2281284
FIELD: organic chemistry, medicine, virology, pharmacy.SUBSTANCE: invention relates to new non-nucleoside inhibitors of reverse transcriptase activity of the formula (1): wherein R1 represents oxygen atom (O), sulfur atom (S); R2 represents optionally substituted nitrogen-containing heterocycle wherein nitrogen atom is at position 2 relatively to the bond with (thio)urea; R3 represents hydrogen atom (H), (C1-C3)-alkyl; R4-R7 are chosen independently from hydrogen atom (H), (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, halogen-(C1-C6)-alkyl, (C1-C6)-alcanoyl, halogen-(C1-C6)-alcanoyl, (C1-C6)-alkoxy-, halogen-(C1-C6)-alkoxy-group, hydroxy-(C1-C)-alkyl, cyano-group, halogen atom, hydroxy-group; X represents group of the formula: -(CHR8)-D-(CHR8)m- wherein D represents -O or -S-; R8 represents hydrogen atom (H); n and m represent independently 0, 1 or 2, and to its pharmaceutically acceptable salts. Also, invention relates to a pharmaceutical composition based on these compounds possessing inhibitory effect with respect to activity of HIV-1 reverse transcriptase, and to using these compounds in preparing medicinal agents used in treatment of HIV-1 and to intermediates compounds.EFFECT: valuable medicinal and biochemical properties of compounds and composition.45 cl, 1 tbl, 57 ex

Vitamin d analogs, pharmaceutical and cosmetic composition containing the same // 2266274
FIELD: pharmaceutical and cosmetic industries, biological aromatic vitamin D analogs.SUBSTANCE: invention relates to compounds selected from group containing (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-in-2-ol, (3E,5E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, (E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-in-2-ol; and (3E,5E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, as well as from abovementioned compounds wherein one or more hydroxyl groups have protective group of formula -(C=O)-R, wherein R represents linear or branched C1-C6-alkyl, or C6-C10-aryl, or C7-C11-aralkyl; and aryl and aralkyl radicals may be substituted with one or two hydroxyl groups, C1-C3-alkoxy groups, halogen atoms, nitro or amino groups. Also disclosed are methods for application of said analogs in pharmaceutical composition with cell proliferation and differentiation activity useful in therapy and veterinary (i.e. dermatology, oncology, autoimmune diseases, organ and tissue transplantation), as well as in cosmetic composition.EFFECT: vitamin D analogs with value pharmaceutical and cosmetic properties.12 cl, 5 tbl, 6 dwg, 10 ex

Triaromatic the vitamin d analogues, pharmaceutical and cosmetic compositions // 2237651
The invention relates to new triaromatic the vitamin D analogues of General formula (I):where R1- CH3or-CH2HE, R2-CH2HE, X-Y - linkage of formula (a) or (C)where R6- H, lower alkyl, W is O, S or-CH2-, Ar1, Ar2the cycles of formula (e), (j), (k), (m)R8, R9, R11, R12- H, lower alkyl, halogen, HE, CF3,R3-where R13, R14- lower alkyl, CF3, R15- H, acetyl, trimethylsilyl, tetrahydropyranyl, or their salts

New tricyclic derivatives (options), the pharmaceutical composition (options), the method of suppressing the immune reaction or treatment and/or prevention of allergic diseases (options) // 2216533
The invention relates to new tricyclic derivative of the formula (I), (Ia'), (Ib'), (Ig'), (If'), their salts and hydrates, which have immunosuppressive or anti-allergic activity, pharmaceutical compositions based on these compounds and to a method of suppressing immune response or treatment and/or prevention of allergic diseases

The method of separation of the enantiomers of racemic 3-(2 - methoxyphenoxy)-1,2-propane diol and 3-(2-methylphenoxy)-1,2 - propane diol // 2213724
The invention relates to a method for separation of the enantiomers of racemic 3-(2-methoxyphenoxy)-1,2-propane diol and 3-(2-methylphenoxy)-1,2-propane diol, which can be used in the pharmaceutical industry in obtaining narramissic drugs

The way to obtain 1,5-bis(2-hydroxyphenoxy)-3-oxapentane monohydrate // 2203882
The invention relates to a method for producing 1,5-bis(2-hydroxyphenoxy)-3-oxapentane monohydrate, which is an intermediate product in the synthesis of crown ethers used as extractants cesium

Transnistria phenyl derivatives // 2188188
The invention relates to trehzameshchenny phenyl derivative of the General formula (1) in which Y represents a group or SIG1where R1represents a C1-C6alkyl group, optionally substituted by up to three halogen atoms; R2represents a C1-C6alkyl or C3-C8cycloalkyl provided that Y and-OR2are not both methoxypropane; R3represents a hydrogen atom or a hydroxy-group; R4and R5that may be the same or different, represent a group -(CH2)nAr, where n = 0 or 1 and Ar is a phenyl or heteroaryl group containing one or two 5 - and/or 6-membered ring containing up to three heteroatoms selected from oxygen, sulfur and nitrogen, where Ar is optionally substituted with halogen, C1-C6the alkyl, C1-C6hydroxyalkyl,1-C6alkoxy, C1-C6alkoxy-C1-C6the alkyl, C1-C6halogenation, amino,di-(C1-C6)alkylamino-C1-C6by alkyl, hydroxyl, formyl, carboxyla,1-C6alkoxycarbonyl,1-C6alkanoyloxy, thiol, carboxamido,1-C6alkanolamine,

Derivatives of cyclohexane or tetrahydropyran, or their pharmaceutically acceptable salt, or a hydrate, or a solvate of these compounds, or their salts, intermediate compounds for their preparation and fungicidal agent // 2084439
The invention relates to new derivatives of cyclohexane and tetrahydropyrane, the way they are received, fungicidal compositions on their basis and use of this composition for combating fungi

The method of producing monoamino of pyrocatechin // 2051142
The invention relates to methods of obtaining monoamino of pyrocatechin, namely nanometrology ester pyrocatechin guaiacol and monoecious ester pyrocatechin of guadala used as raw material in the synthesis of aromatic substances, in particular, in the synthesis of vanillin and vanillal, and medicinal substances
 
2551265.
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