By reaction of esters of mineral or organic acids with hydroxy or o-metal groups (C07C41/16)

C   Chemistry; metallurgy(318327)
C07   Organic chemistry(61593)
C07C41/16                     By reaction of esters of mineral or organic acids with hydroxy or o-metal groups(30)

ethod for alcoxyphenol and alcoxyhydroxybenzaldehyde production // 2628525
FIELD: chemistry.SUBSTANCE: method for alkoxyphenol production comprises O-alkylation of at least one hydroxyphenol to form at least one alkoxyphenol, at that, the said reaction is carried out using an O-alkylating agent, an aqueous solvent containing a Bronsted base and an organic solvent with a base/O-alkylating agent ration in the range of 0.5 to 1.5 moles of base per mole of O-alkylating agent, with an O-alkylating agent/hydroxyphenol ratio in the range of 0.5 to 2 moles of O-alkylating agent per mole of hydroxyphenol and with an organic solvent/hydroxyphenol ratio of less than 280 ml, preferably in the range of 10 to 250 ml and more preferably in the range of 50 to 150 ml of an organic solvent per mole of hydroxyphenol. One of the versions of the alkoxyhydroxybenzaldehyde production method comprises preparation of alkoxyphenol from hydroxyphenol by the foregoing method and a reaction of the aldehyde group addition to the resulting alkoxyphenol to obtain the corresponding alkoxyhydroxybenzaldehyde, preferably by condensation reaction between alkoxyphenol and glyoxylic acid, followed by oxidation of the resulting compound.EFFECT: proposed method for alkoxyphenol production allows the desired product to be obtained in good yield and high purity with high conversion of initial hydroxyphenol.11 cl, 3 dwg, 7 ex

ethod of obtaining sglt2 benzylenbenzole inhibitors // 2625795
FIELD: chemistry.SUBSTANCE: invention relates to a process of obtaining SGLT2 benzylenbenzole inhibitors, producing an inhibitory effect on sodium-dependent glucose transporter of compound of formula , comprising (a) production of the first reaction mixture, containg formula : alkyl magnesium complex selected from groups, consisting of C1-C4 alkyl magnesium chloride, C1-C4 alkyl magnesium bromide, (C1-C4 alkyl) dimagnesium, C3-C7 cycloalkylmagnesium chloride, C3-C7 cycloalkylmagnesium bromide and (C3-C7 cycloalkyl) dimagnesium and the first organic solvent, where proportion of alkil magnesium complex and the compound of formula IIa is selected from 0.9, 0.91, 0.92, 0.93, 0.94, 0.95, 0.96 and 0.97 (mmol/mmol), where the first reaction mixture is at a temperature of -50C or lower, with formation of an intermediate compound; and (b) production of the second reaction mixture containing an intermediate compound, a second organic solvent and a compound of formula IIIa: with formation of compound of formula Ia where R4 is OH and each Ra is Rb; (C) obtaining the third reaction mixture containing C1-C3 alkyl hydroxy, a strong acid and a compound of formula Ia where R4 is OH and each Ra is Rb, with formation of a compound of formula Ia where R4 is C1-C3 alkoxy, and each Ra is independently seleted from the group, containg H and Rb; and (d) obtaining of the fourth reaction mixture, comprising a reducing agent and a compound of formula Ia where R4 is C1-C3 alkoxy and where the reaction mixture contains less than 0.1 magnesium equivalents in relation to quantity of compound of formula Ia with formation of a compound of formula Ia, where R4 is H, where X is iodine, R1 is chlorine, R2 is H, R3 is (C3-C6 cycloalkoxy) C1-C3 alkoxy, R4 is selected from the group consisting of H, OH and C1-C3 alkoxy, each R4 is independently selected from the group, consisting of H, C1-C3 alkyl and Rb. Rb is a protection group, where alkyl, alkoxy and cycloalkyl groups or their parts can optionally be completely or partially fluorinated and one or more hydrogen atoms may optionally be replaced with deuterium atoms and synthetic intermediates which can be used for obtaining such compounds. .EFFECT: increase the output of desired product and decrease the amount of by-products.38 cl, 2 tbl, 7 dwg, 25 ex
ethod of producing bis-2-hydroxyethyl ether of 4,4'-dioxydiphenyl-2,2-propane // 2487861
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing bis-2-hydroxethyl ether of 4,4'-dioxydiphenyl-2,2-propane, which can be used to modify polyester fibres, as well as in production of polycarbonates. The method involves reaction of 4,4'-dioxydiphenyl-2,2-propane with 2-oxo-1,3-dioxolane in an inert medium in the presence of a catalyst at temperature of 1505C until carbon dioxide release stops. The catalyst used is a tetramethylammonium salt of monomethyl ether of carbonic acid of formula [N(CH3)4][CO3CH3], and the end product is separated by washing with water.EFFECT: invention enables to obtain the end product with high output using a simple and environmentally safe method.4 ex, 1 tbl

ethod of producing alkyl-glycerine ethers from marine fats // 2415125
FIELD: chemistry.SUBSTANCE: invention relates to a method of extracting alkyl-glycerine ethers having high biological activity from marine fats. The method involves alkaline hydrolysis of fat, acidification of the mixture, washing the mixture with water, first crystallisation of the mixture in an organic solvent, filtration, drying, second crystallisation of the intermediate product from the organic solvent, filtration and drying. The organic solvent used during first and second crystallisation is hexane or acetone and during the first and second crystallisation, the fat mixture is held in the organic solvent first for 12 hours at room temperature and then for 12-15 hours at 0-4C, where during the first crystallisation, the ratio of the fat mixture to the organic solvent is equal to 1:10 kg/l, 1:50 kg/l during the second crystallisation, for hexane and 1:10 kg/l for acetone.EFFECT: invention obtaining end products with high degree of purity and high output using an efficient and cheap method.4 cl, 8 ex

ethod of producing polyfluoroallyl esters // 2406718
FIELD: chemistry.SUBSTANCE: present invention relates to a method of producing polyfluoroallyl esters containing halogen atoms different from fluorine - valuable monomers for synthesis of various copolymers used as sealing materials in various engineering fields, for example aviation engineering and electronics industry. The method involves reaction of acid fluorides of polyfluorohalogen carboxylic acids with a group I metal fluoride in aprotic solvent and then reacting the formed metal alkoxide with perfluoroallyl fluorosulphate. The process takes place in the presence of a quaternary phosphon salt of general formula: , where X - CI, Br, I n=1-10, in amount of 0.01-0.05 mole per mole of metal fluoride.EFFECT: method enables to obtain desired products with high output.1 tbl, 23 ex

Novel method of 3-[5'-(3,4-bis-hydroxymethylbenzyloxy)-2'-ethyl-2-propylbiphenyl-4-yl]penta-3-ol obtainment // 2392268
FIELD: chemistry.SUBSTANCE: method involves: transformation of 1-(4-hydroxy-3-propylphenyl)propane-1-on under effect of trifluoromethane sulphone anhydrite (Tf2O) in the presence of triethylamine (NEt3) into its derivative 4-propyionyl-2-n-propylphenyl ether of trifluoromethane sulphonic acid, with further concentration by Suzuki reaction type with 2-ethyl-5-metoxyphenylboronic acid in the presence of K2CO3, PdCl2(PPh3)2 or Pd(PPh3)4 in catalytic amount, obtaining 1-(2'-ethyl-5'-metoxy-2-propylbiphenyl-4-yl)propane-1-on; demethylation of 1-(2'-ethyl-5'-metoxy-2-propylbiphenyl-4-yl)propane-1-on by heating in the absence of solvent with pyridine salt excess, obtaining 1-(2'-ethyl-5'-hydroxy-2-propylbiphenyl-4-yl)propane-1-on; transformation of 1-(2'-ethyl-5'-hydroxy-2-propylbiphenyl-4-yl)propane-1-on into 6-ethyl-4'-(1-ethyl-1-hydroxypropyl)-2'-propylbiphenyl-3-ol by reaction with ethylmagnesium bromide or ethyllithium, and condensation of 6-ethyl-4'-(1-ethyl-1-hydroxy-propyl)-2'-propylbiphenyl-3-ol with dimethyl ether of 4-bromomethylphthalic acid, with further recovery reaction by lithium borohydride in situ. Claimed method allows for obtainment of target product with high output. Also invention refers to novel 6-ethyl-4'-(1-ethyl-1-hydroxypropyl)-2'-propylbiphenyl-3-ol compound used as intermediary product in the claimed method.EFFECT: possible application in medicine.17 cl, 1 dwg, 1 ex

Novel trimethylcyclododecatriene derivatives, use thereof and perfumed products containing said derivatives // 2384557
FIELD: chemistry.SUBSTANCE: invention relates to mixtures of fragrant compounds selected from a mixture of compounds (5a-d), (6a-d), (6a'-6d'), (7a-d) and (7a'-7d'), to a method of preparing said mixtures, to fragrant, perfumed and cosmetic compositions, as well as to household chemicals based on said compounds and to use of said mixtures or fragrant compositions based on said compounds as a fragrant agent, an agent which masks or neutralises smell. (5a-d), (6a-d) and (7a-d), where R denotes a methyl group, (6a'-6d') and (7a'-7d'), where R denotes an ethyl group.EFFECT: preparing the mixtures of fragrant compounds.16 cl, 1 dwg, 8 ex

ethod of obtaining simple polyfluoroalkyl ethers // 2346926
FIELD: chemistry.SUBSTANCE: invention concerns method of obtaining simple polyfluoroalkyl ethers of the formula H(CF2)nCH2OR (n=2, 4, 6; R=n-Pr, n-Bu, iso-Bu, n-C5H11, iso-C5H11, n-C6H13, C6H11(cyclohexyl), RF (where RF=H(CF2)nCH2, n=2, 4, 6, 8), Ph, ArCH2 (where Ar=Ph, p-Cl-Ph, p-CH3O-Ph, m-NO2-Ph)) by reaction of respective alcohols or phenol with polyfluoroalkylchlorosulfites in the presence of solvent, the reagents mixed at - 10 - -5°C. Alcohols or phenol are added to polyfluoroalkylchlorosulfite solution in portions mixed with N,N-dimethylformamide catalyst at mol ratio of 1:(1-1.1):(0.005-0.1) respectively. Reaction is performed at 40-50°C for 4-6 hours, and exuded sulfur dioxide and hydrochloride are blown off by inert gas.EFFECT: high output and simplified process of obtaining polyfluoroalkyl ethers.1 tbl, 28 ex

ethod for production of 4-methoxymethyl-2,3,5,6-tetrafluorobenzenemethanole // 2247707
FIELD: new for production of 4-methoxymethyl-2,3,5,6-tetrafluorobenzenemethanole useful as synthetic intermediate for insecticide compounds.SUBSTANCE: claimed method includes a) interaction of 2,3,5,6-tetrafluoro-1,4-benzenemethanole with inorganic base in water, followed by b) addition of dimethyl sulfate and water-immiscible organic solvent selected from group, containing hydrocarbons and ethers, to reaction mixture; or a) interaction of 2,3,5,6-tetrafluoro-1,4-benzenemethanole with inorganic base in water and water-immiscible organic solvent selected from group, containing hydrocarbons and ethers, followed by b) addition of dimethyl sulfate to reaction mixture.EFFECT: selective method for high-yield manufacturing of high-purity target product.10 cl, 10 ex

The method of obtaining simple esters of 3,5-dialkyl(diaryl or dialkyl)-4-alcohols oxybenzoic // 2112767
The invention relates to the field of petrochemicals, more specifically to methods for stabilizers for rubbers, thermoplastic elastomers and rubbers

The method of obtaining dialkylated ethers of diethylene glycol // 2085553
The invention relates to chemical technology, in particular to a technology for modifier catalyst for polymerization of diene hydrocarbons and can be used in the synthetic rubber industry