Chemistry and metallurgy (C)

C            Chemistry; metallurgy(318327)
C01 - Inorganic chemistry(20787)
C06 - Explosives; matches(2093)
C07 - Organic chemistry(61593)
C13 - Sugar industry(2232)
C21 - etallurgy of iron(23203)
C30 - Crystal growth(2110)

Cathode unit having groove of variable depth and completed intermediate space // 2642815
FIELD: electricity.SUBSTANCE: cathode device comprises a cathode unit based on carbon and/or graphite, in which, at least, one groove is made, extending in the longitudinal direction of the cathode unit and having a variable depth along the cathode unit, which houses a tyre, wherein an intermediate space between the tire and the bottom of the groove of a variable depth is, at least, partially filled with steel selected from the group with a low content of carbon, silicon, and phosphorus.EFFECT: uniform vertical current distribution along the length of the cathode unit during the operation of the electrolyser.9 cl, 1 dwg
ethod of obtaining copper - graphen composite // 2642800
FIELD: chemistry.SUBSTANCE: water-alcohol solution of copper sulfate is prepared, ethyl alcohol is added to it to a concentration of 37.5-42.5 ml/l, acidified to pH of 1-2 and divided into two parts. A suspension is prepared from one part, in which graphite-graphene mixture is added in an amount of 0.05-0.5 g/l and surfactants Pluronic F-127 or polyacrylic acid in an amount of 25-100 ppm, dispersed for 15-20 min. The electrochemical deposition cell is assembled, placed in a copper solution and the working voltage is fed for 20-30 minutes. Then the two-electrode cell is moved to the obtained graphene-containing suspension with surfactants and the working voltage is fed to the electrodes for 120-180 min. After the specified aging in the solutions, the electrodes are dried, and the resulting composite "copper-graphene" is separated, which has a high uniformity and crystallinity, a small crystallite size, a uniform distribution of graphene in the matrix.EFFECT: increase of the material microhardness.1 cl

Discharge camera for plasma chemical reactions // 2642798
FIELD: electricity.SUBSTANCE: discharge chamber includes two coaxial electrodes, a dielectric barrier and removable discharge initiators, installed on one of the electrodes. The dielectric barrier is located between the electrodes with gaps relative to each of the electrodes. The discharge initiators enter the annular grooves made in the electrode. The gap of H size between the dielectric barrier and the electrode with the grooves is filled with a flowing working gas. The discharge initiators are fixed in the paired annular grooves with removable clamping elements in such a way that the distance L between the areas of the above initiators, facing in the direction of the dielectric barrier, and the dielectric barrier satisfies the condition 0.25H≤L≤0.5H. The gap between the dielectric barrier and the other electrode is filled with a circulating electrically-conductive fluid.EFFECT: increase of the maximum capacity of the discharge chamber on the initiated barrier discharge of a repetitively pulsed action.4 cl, 6 dwg
Processed fillers, compositions containing them, and products produced from them // 2642795
FIELD: chemistry.SUBSTANCE: method of producing a treated filler comprises treating the suspension containing a raw filler that is not pre-dried using a treating composition containing a treating agent. The treating agent comprises at least one compound selected from an unsaturated fatty acid containing a linear or branched optionally substituted C4-C38alkyl having at least one carbon-carbon double bond; a derivative of the said unsaturated fatty acid, wherein at least one carbon-carbon double bond is reacted to include at least one functional group; and/or salts of the said unsaturated fatty acid. The untreated filler is selected from aluminium silicate, silica gel, colloidal silicon dioxide, precipitated silica, and mixtures thereof. The suspension of the treated filler is dried to obtain a treated filler.EFFECT: invention makes it possible to improve the compatibility of materials with a high specific surface area with the polymer matrix into which they are incorporated, to reduce the process viscosity and to prevent the phase separation of these materials and the polymer matrix.39 cl, 10 tbl, 2 ex

Submersible flat devices for direct osmosis // 2642794
FIELD: chemistry.SUBSTANCE: membrane device for direct osmosis is suitable for immersion in a pool for evaporation of salt water under the influence of solar radiation to pre-concentrate the brine. The membrane has a flat device configuration and includes a flat membrane base having the first and the second sides; the first flat membrane attached in parallel to the first side of the base; the second flat membrane attached in parallel to the second side of the base; the first channel for the flow between the first side of the base and the first membrane, where the first channel for flow has an input side and an output side; the second channel for the flow between the second side of the base and the second membrane, where the second channel for the flow has an input side and an output side; where the membranes around the perimeter are pressed, welded or glued to the base, the input for the inert in the conjunction with the input sides of the first and the second channels for the flow and the output for the inert in the conjunction with the output sides of the first and the second channels for the flow, while the channels for the flow are formed with a woven mesh that is inserted and fixed between the base and membranes.EFFECT: concentration of brines with a high degree of salt concentration, reduced energy consumption, reduction of production areas.5 cl, 9 dwg, 2 ex

Fire-resistant paint // 2642793
FIELD: chemistry.SUBSTANCE: spray paint contains an aqueous suspension of finely powdered particles of expanded vermiculite, where the particles of vermiculite are a mixture of chemically exfoliated vermiculite in an amount of, preferably, approximately 75 to 99 wt %, and thermally exfoliated vermiculite in an amount of, preferably, approximately 1 to 25 wt %. The viscosity of the spray paint measured on a Brookfield viscometer (spindle No. 6, 20 rpm) is preferably in the range of 5,500 to 10,000 cPs.EFFECT: invention provides a refractory and/or fire-resistant paint with good adhesion and non-stickiness.26 cl, 1 dwg, 2 ex
Fire-retardant varnish on organic basis // 2642792
FIELD: chemistry.SUBSTANCE: fire-retardant varnish on an organic basis contains styrene-acrylic resin, solvents, adhesives, and white spirit, biocide-rheological additive, flame retardant-ammonium polyphosphate (APP), thickener-bentonite clay, tris (2-chloroethyl) phosphate in the following ratio of components, wt %: styrene-acrylic resin - 10-15, butyl acetate - 8-15, white spirit - 35-45, biocide-rheological additive - 0.5-2, flame retardant- APP - 20-30, thickener - 0.7-1.2, tris (2-chloroethyl) phosphate - 5-10.EFFECT: increasing the level of the fire safety of products made of wood and plastic, coated with fire-retardant varnish on an organic basis.1 cl
ethod of producing pentafluoroiodoethane // 2642789
FIELD: chemistry.SUBSTANCE: invention relates to the method of producing pentafluoroiodoethane from perfluoro-propene, which includes the interaction of CF3CF=CF2 with the iodine source, such as iodine-halide I-I, I-Br, I-Cl in the presence of inorganic fluoride, or perfluoro-isopropyl-iodide, and sodium methylate in the polar aprotic solvent with the formation of 1,1,1,2,3,3-hexafluoro-2-iodine-3-methoxy-propane, its subsequent demethylation by boiling with pentachloride antimony with obtaining 2,3,3,3-tetrafluoro-2-iodopropionyl fluoride, and decarbonylation of the latter under the action of pentafluoride antimony on heating, which gives pentafluoroiodetane.EFFECT: use of available non-explosive raw materials.4 cl, 5 ex
Copper-zinc-chrome-aluminium catalyst production method // 2642788
FIELD: chemistry.SUBSTANCE: invention can be used for low-temperature methanol synthesis, hydrogenation of nitrobenzene, dehydrogenation of cyclohexanol to cyclohexanone in caprolactam production. A method of producing a copper-zinc-chromium-aluminium catalyst is carried out by mixing a solution of ammonium carbonate complex of copper with zinc and aluminium compounds followed by drying, calcining, and pelletizing the catalyst mass, characterized zinc oxide and powder of aluminium oxide γ-modified with a grinding of less than 100 µm is gradually introduced into the ammonia-carbonate complex solution of copper, the resulting suspension with a ratio of solid: liquid, equal to 1.0:(12.0-15.0) is heated under stirring in the temperature range of 60-90°C to obtain a mass ratio solid: liquid equal to 1.0:(0.01-0.5), then chromic anhydride or an aqueous solution is introduced, the formed chromium-containing mass is homogenized at a temperature in the interval of 70-90°C, dried, calcined at a temperature of generating a catalyst in which chromium is in the oxidation state of Cr3+ and Cr6+, and the content of Cr6+ and Cr3+ is in relation Cr6/Cr3+, equal to 0.13 and 0.8, preferably 0.39-0.55, and pelletized.EFFECT: creation of a simple and economical technology for the preparation of a mixed copper-zinc-chromium-aluminium catalyst, which does not have harmful wastewater and gas emissions, and provides a highly active stable catalyst.2 tbl, 19 ex

ethod and system for lignin processing // 2642787
FIELD: chemistry.SUBSTANCE: method of separating lignin from lignin-containing medium, such as liquid made in the method of processing biomass, for example, from a black alkaline solution produced in the enterprise of recycling of pulp, and processing the separated lignin, includes: the precipitation of lignin from lignin-containing liquid medium, followed by exposure of lignin hydrothermal carbonization in the wet state and the removal of carbonaceous material derived from lignin as a result of the carbonization after the implementation of the hydrothermal carbonization, the method further includes: the regulation of the particle size of the carbonaceous material by bringing the pH value of lignin in the wet state before the hydrothermal carbonization to a value exceeding 7, preferably exceeding 8. The system, a carbon-containing product and the application of the product are also declared.EFFECT: obtaining a hydrocarbon product with a controlled particle size and increasing the profitability of the process.17 cl, 2 dwg

Liposomal suspensions stabiliser // 2642786
FIELD: pharmacology.SUBSTANCE: conjugate of the invention is a compound of formula (C6O4H9NH2)m(C6O4H9NHX)n, wherein the remainder of the polyethylene glycol derivative, which is a monomethoxy-PEG succinate acts as a substituent on the amino group X, the molecular weight of chitosan used to prepare the conjugate is 15 to 120,000 daltons, am and n are the number of units in the molecule, where m/n is 6 to 19. The proposed method involves preparation of a solution of N-hydroxysuccinimide ester of PEG-hemisuccinate in dimethylformamide or dimethylsulfoxide, mixing of the solution prepared with an acidic solution of chitosan with a molecular weight of 15-120 kDa, and adjustment of the resulting mixture to a pH of 7.5-8.0, followed by purification by dialysis against buffer solution.EFFECT: new substance effective for liposomal suspensions stabilization is disclosed, and an effective method for its preparation.3 cl, 3 dwg, 4 ex

Fluorine-9-methyl-β-carbolines // 2642785
FIELD: pharmacology.SUBSTANCE: invention relates to a compound of the general formula (I) , where R1 is -F, and R2 is -H or -F, or R1 is -H, and R2 is -F; which can be used as a medicine for treatment of diseases and/or injuries of the inner ear.EFFECT: increased efficiency of compounds.10 cl, 30 dwg, 1 tbl, 9 ex
Forzicyaside sulfate and its derivatives, method for its production and its application // 2642784
FIELD: pharmacology.SUBSTANCE: invention relates to forzicyaside sulfate and its derivative represented by the following formula , wherein R is Na+, K+ or NH+, and a method for their preparation, as well as an antiviral drug based on them and its use.EFFECT: increased efficiency of agents.10 cl, 9 tbl, 2 dwg
New benzoazepine derivative and its medical application // 2642783
FIELD: pharmacology.SUBSTANCE: invention relates to a new benzoazepine derivative of formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents a hydroxyl group, a lower alkoxy group or , where A is absent or a lower alkylene group which may be substituted by a lower alkyl group; R6 represents a hydrogen atom or a lower alkyl group; R7 represents a hydrogen atom, a hydroxyl group, a five-membered aromatic heterocyclic group containing 3 heteroatoms selected from nitrogen and oxygen which may be substituted by a lower alkyl group, a five-membered non-aromatic heterocyclic group containing one nitrogen atom which may be substituted by an oxo group or a carbamoyl group , which may be substituted by a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 is a lower alkyl group which may be substituted by 1 to 3 fluorine atoms or a halogen atom; R4 represents a lower alkoxy group which may be substituted by 1 to 3 halogen atoms, a five-membered aromatic monocyclic heterocyclic group or a five-membered non-aromatic monocyclic heterocyclic group (provided that each of these heterocyclic groups contains one nitrogen atom, two nitrogen atoms or one nitrogen atom and one oxygen atom in the ring, and may contain a lower alkyl group); and R5 represents a hydrogen atom, a lower alkyl group or a halogen atom. The invention also relates to a pharmaceutical composition based on a compound of the formula and intermediates of the formulas and .EFFECT: new benzoazepine derivatives having V2 receptor agonist activity are obtained.14 cl, 12 tbl, 128 ex

Systems and methods for protection of electrolyser side walls // 2642782
FIELD: electricity.SUBSTANCE: electrolyser comprises the following: an anode, a cathode spaced from the anode, a molten electrolyzing bath in fluid communication with the anode and cathode. The molten electrolyzing bath has a chemical composition of a bath comprising at least one bath component, a housing having a bottom and at least one side wall surrounding the bottom. Herein the electrolyser housing is designed to hold the molten electrolyzing bath. The side wall essentially consists of said at least one component of the bath, wherein the side wall further comprises the following: the first side wall part adapted to be mounted on a heat insulating lining of the side wall and holding the electrolyte and the second side wall part formed protruding upward from the bottom of the electrolyser housing. Wherein the second side wall part is longitudinally spaced from the first side wall part, so that the first side wall part, the second side wall part and the base between the first part and the second part form a trough. The trough is configured to receive and hold a protective precipitate separately from the electrolyser bottom. The protective precipitate can dissolve from the trough into the molten electrolyzing bath so that the molten electrolyzing bath has a level of said at least one bath component that is sufficient to maintain the first side wall part and the second side wall part in the molten electrolyzing bath.EFFECT: elements of the electrolyser side wall allow protecting the side wall from the electrolyzing bath.33 cl, 1 ex, 11 dwg

Capsules, containing water-soluble fibre walls materials and methods of its manufacture // 2642781
FIELD: textile, paper.SUBSTANCE: provided capsule for using in laundry, comprising the water-soluble fibre wall material, that defines the internal volume of the capsule, at that the water-soluble fibre wall material, comprising one or more filaments, at that one or more active agents being present in and can be released from at least one filament, when the capsule is subjected to the targeted use conditions influence, and the capsule further comprises the active agent in the internal volume of the capsule.EFFECT: capsule creation, made of fibre wall material, at that the capsule being characterized by the rapid release of its contents under the conditions of the targeted use.20 cl, 3 tbl, 13 dwg

ethod of producing linear block-copolymers (meth) acrylic monomers // 2642780
FIELD: chemistry.SUBSTANCE: method of producing linear block-copolymers of methacrylic monomers involves sequentially synthesizing the first and the second blocks of copolymers by the controlled radical polymerization. At the first stage, obtaining a polymethacrylate initiator is carried out through the synthesis of its monomer A with dinitrile of isoiso-butyric acid used as an initiator, and 4,6-di-tert-butyl-N-(2,6-diisopropylphenyl)-o-imino-benzoquinone used as a polymerization regulator, when their molar ratio of monomer: initiator: polymerization regulator as 1000:(1÷8):(1÷8) for 3-20 hours at a temperature of 70°C, at the second stage obtaining a diblock-copolymer is carried out by the copolymerization of the obtained polymethacrylate initiator with the monomer B, in their weight ratio of (10-25):(90-75) for 1-15 hours at a temperature of 70°C. The monomer B is not styrene, or styrene is used as the azeotropic mixture with methyl methacrylate as the monomer B if methacrylate is used as the monomer A or styrene is used as the monomer B when n-butylmethacrylate is used as the monomer A.EFFECT: production of finely dispersed block-copolymers of various molecular weights and with the variation of monomeric compositions.7 cl, 2 tbl, 3 dwg
Comt inhibitors // 2642779
FIELD: pharmacology.SUBSTANCE: invention relates to new compounds of the formula (I) and their pharmaceutically acceptable salts which have the properties of a catechol-O-methyltransferase (COMT) inhibitor. In the compound of the formula (I) , where R1 is hydrogen, methyl, Br, F or Cl; R2 is hydrogen, lower alkyl, Br, I, C3-6cycloalkyl, C(O)O-lower alkyl, C(O)NH-lower alkyl substituted by halogen, C(O)(morpholine) or is 3,4-dihydronaphthalen-2-yl optionally substituted by lower alkyl, 1,2,3,4-tetrahydronaphthalen-2-yl, 2,3-dihydrobenzofuran-6-yl, 1-methyl-2,3-dihydro-1H-indolin-5-yl, 1-methylindolin-5-yl, tetrahydropyran-4-yl, 3,6-dihydro-2H-pyran-4-yl, 2-isopropyl-1,2,3-tetrahydroisoquinolin-5-yl, 2,3-dihydro- dimethyl[1,4]dioxin-6-yl, benzo[1,3]-dioxol-5-yl, 1,2,3,4-tetrahydroisoquinolin-7-yl optionally substituted by lower alkyl, cyclohexenyl, morpholinyl, 4-methylpiperazinyl, naphthalen-1-yl, naphtalen-2-yl, or represents (CHR)n-phenyl optionally substituted by one to five substituents R4, where R4 is F, Cl, CN, CH2-CN, lower alkyl, hydroxy, lower alkyl, substituted hydroxy, lower alkoxy, (CH2)1.2-lower alkoxy, S-lower alkyl, (CH2)1.2-S-lower alkyl, -CH2)1.2-S (O)2-lower alkyl, -S(O)2-lower alkyl, -S(O)2-di-lower alkylamino, -S(O)2-piperidinyl, lower alkyl substituted by halogen, -N=N-phenyl, di-lower alkylamino, (CH2)1.2-di-lower alkylamino, (CH2)2-NH-lower alkyl, NHC(O)-lower alkyl, lower alkoxy substituted by halogen, CH(CH3) C(O)O-lower alkyl, O-phenyl, O-benzyl, phenyl, optionally substituted CF3, SF5, benzyl, C(O)-lower alkyl, C(O)-phenyl, C(O)-morpholinyl, C(O)-4-methylpiperazinyl, C(O)-di-oxothiomorpholinyl, C(O)-piperidinyl, optionally substituted by F, C(O)-NH-(CH2)2-morpholinyl, C(O)-NR-(CH2)2-NR2, C(O)-N-di-lower alkyl, CH2-O-(CH2)2-4-methylpiperazinyl, CH2-O-(CH2)2-di-alkylamino, CH2-O-(CH2)2-pyrrolidinyl, CH2-O-(CH2)2-morpholinyl, CH2-O-(CH2)2-piperidinyl optionally substituted by lower alkyl substituted by halogen or lower alkyl, (CH2)3,4-pyrrolidinyl, (CH2)2,3-di-lower alkylamino, morpholinyl, CH2-morpholinyl, CH2-piperazine substituted by lower alkyl, -S(O)2-piperazine substituted by lower alkyl, CH2-O-C(O)-piperazine substituted by lower alkyl, pyrazolyl or (CH2)1,2-lower alkoxy; R is hydrogen, lower alkyl or hydroxyl; n is 0, 1, 2, or 3; or R2 is C(O)-phenyl optionally substituted by lower alkyl; or is -O-phenyl optionally substituted by F; or is CH=CH-phenyl optionally substituted by lower alkyl; or is C≡C-phenyl; or R2 is a heteroaryl selected from the group consisting of pyrazolyl, thiazolyl, pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl, isothiazolyl, thiophenyl, 1-thia-3,4-diazolyl, imidazo[1,2-a]pyridinyl, indazolyl, quinolinyl or isoquinolinyl, and the said groups are optionally substituted by R5, where R5 is halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, hydroxy, (CH2)1.2-lower alkoxy, CH2-di-lower alkylamino, di-lower alkylamino, morpholinyl, piperazinyl, pyrrolidin-1-yl, C(O)-piperidinyl, C(O)-4-methylpiperazinyl, phenyl optionally substituted by halogen, pyridinyl, S(O)2N(CH3)2, C(O)O-lower alkyl, NHC(O)-lower alkyl, or is C(O)-heteroaryl selected from pyridinyl and thiophenyl, where heteroaryl groups are optionally substituted by lower alkyl, n is 0, 1, 2 or 3; R3 is hydrogen, methyl, Br, F, Cl, CF3, nitro, amino, cyano, NHC(O)-phenyl, or is 1-methyl-1,2,3,6-tetrahydropyridinyl, or is pyridinyl optionally substituted by methyl or morpholinyl, or is phenyl optionally substituted by methyl , SO2CH3, CF3, CN, F or C(O)N (di-lower alkyl).EFFECT: compounds can be used to treat Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.16 cl, 2 tbl, 256 ex
ethod for obtaining of 1-r-indole-3-ylsulfanylacetates of (2-hydroxyethyl)ammonium // 2642778
FIELD: pharmacology.SUBSTANCE: invention relates to a method for the preparation of indole-1-H-, 1-methyl-, 1-benzylindole-3-ylsulfanylacetate of (2-hydroxyethyl)ammonium heterocyclic compounds that have a broad spectrum of action, for example, selective erythropoiesis and immunomodulators with a minimum potential for undesirable effects on various body systems, and can be used to prevent and treat immune-dependent lesions that occur with anaemia, cancer and inflammatory diseases, complications with organs and bone marrow transplantation, protection against cardiogenic shock, stresses, etc. The method consists in the reaction of 1-R-indole-3-ylsulfanyl acetic acids with (2-hydroxyethyl)amines - triethanolamine, methyldiethanolamine, dimethylethanolamine without solvent upon heating to 60-65°C for 0.5-1 hour, with washing of the resulting salt with ether. The yield is 92-99%. The initial 1-R-indole-3-ylsulfanyl acetic acids (compounds 2) are obtained for this reaction from 1-H- or 1-methyl-or 1-benzylindole with thiourea, bromine, potassium bromide, taken in the molar ratios of 1:2:1:1, respectively, in a water medium at a temperature of 30-40°C for 3 h in inert gas, with subsequent processing of the reaction mass by an aqueous solution of sodium hydroxide, then an aqueous solution of monochloroacetic acid taken in the molar ratios of indole, sodium hydroxide, acid 1:(4-5):(1-1.2), heating of the reaction mixture at 90-100°C for 3 h at a pH of 9-10 with subsequent acidification with hydrochloric acid until pH=1 with a yield of 92-95%. Purity is 98.7-99.7. Replacement of scarce and expensive iodine and potassium iodide in alcohol solution with a more accessible aqueous solution of bromine and sodium bromide, excluding toxic hydrazine hydrate and toxic solvent (alcohol) from the process leads to a decrease in product cost and an increase in environmental fire safety, since the reaction is carried out in an aquatic environment. , R=H, CH3, CH2C6H5; R1, R2=H, CH3, CH2CH2OH; n=1-3.EFFECT: increased efficiency of compounds application.2 cl, 2 dwg, 8 ex
2-aminopyrasine derivatives as csf-1r kinase inhibitors // 2642777
FIELD: pharmacology.SUBSTANCE: invention relates to a compound that is an amino acid or ester of an amino acid of formula , or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against CSF-1R kinase. In formula (I), ring A is a phenyl group; R1 and R2 independently represent a hydrogen atom, a halogen atom or an unsubstituted C1-4 alkyl; n is 1; X is NH; V is -N=, W is -C(Z)=; Z represents a hydrogen atom, a fluorine atom, a chlorine atom or unsubstituted C1-3 alkyl; ring B is a 1,4-phenylene, 1,3-phenylene or pyridinyl group; [Linker] is a -(CH2)m-X1-(Alk1)x-Y1 group, where m is 0, 1, 2 or 3; x is 0 or 1; Alk1 is an unsubstituted C1-3 alkylene group; X1 and Y1 independently represent a bond, -O-, -S-, -NR7th-, -C(=O) - or -C(=O)NR5-, where R5 is a hydrogen atom or C1-4 alkyl and R7 is a hydrogen atom, unsubstituted C1-4 alkyl or -C(=O)CH3; R is a group of formula or , in which R8 is a -COOH group or an ester group of the formula -(C=O)OR14, where R14 is R15R16R17C-, where any R15 represents a hydrogen atom or C1-3alkyl-(Z1)a-[(C1-C3)alkyl]b-, where a and b are independently 0 or 1, Z1 is -O-, -S- or -NH-, R16 and R17 independently represent a hydrogen atom or C1-3 alkyl- or R15 and R16, taken together with the carbon atom to which they are attached, form a 3-7-membered cycloalkyl ring; and R17 represents a hydrogen atom; where (i) R9 and R10 are side chains of natural amino acids, (ii) one of R9 and R10 represents a hydrogen atom or unsubstituted C1-4 alkyl, and the other is an unsubstituted C1-6 alkyl group or C1-6 alkyl group substituted by a C1-4 alkoxy group, or (iii) R9 and R10, taken together with the carbon atom to which they are attached, form a saturated spiro-cyclobutyl ring; R11 represents a hydrogen atom or an unsubstituted C1-2alkyl group; ring D is a 5- to 7-membered saturated heterocyclyl group with at least one nitrogen atom in the ring. The invention also relates to a pharmaceutical composition, a method of treatment or prevention of diseases or disorders mediated by CSF-1R kinase, as well as application of the said compounds for preparation of a medicament useful for treatment of such diseases.EFFECT: increased application efficiency.18 cl, 59 ex
Thermal insulating glued arbolite // 2642757
FIELD: construction.SUBSTANCE: heat-insulating glued arbolite comprises a binder -amino-formaldehyde glue - at the following ratio of components: aggregate with a fraction up to 3 mm from hardwood - 44%; amino-formaldehyde glue - 56%.EFFECT: reduced material consumption, reduced duration of holding wood particles mixed with glue in moulds.1 cl

Production line of manufacturing granulated foam glass // 2642756
FIELD: construction.SUBSTANCE: production line of manufacturing granulated foam glass comprises a feedstock hopper, a grinder, a hopper for a liquid component, granulators, a drum dryer, a vibrating screen, a hopper with a dispenser of dried granules, a hopper with a separating medium. It also comprises a rotary foaming furnace, a rotating refrigerator installed behind the foaming furnace, an accumulation bunker for foamed granules, a warehouse of finished products with two vibrating screens installed in series, each of which is equipped with two meshes and connected through granule collectors and by means of pneumatic conveyors with the hoppers for the finished products. The line additionally comprises a wet-grinding attritor connected to the hopper for a liquid component and a drying and granulation plant connected to the drying drum.EFFECT: increasing the yield of a good product.1 dwg
Glaze // 2642755
FIELD: chemistry.SUBSTANCE: invention relates to the technology of silicates and in particular to glaze compounds, that can be used to cover products made of porcelain, faience, majolica and other ceramics. Glaze contains the following in % wt: SiO2 33.0–35.0; CdO 13.0–15.0; B2O3 33.0–35.0; K2O 1.0–2.0; Al2O3 16.0–17.0.EFFECT: high heat resistance of glaze.1 cl, 1 tbl
ethod of preparing limestone construction rubble // 2642754
FIELD: construction.SUBSTANCE: method of preparing limestone construction rubble includes preheating limestone construction rubble to a temperature of 50-60°C, impregnating the heated rubble in an aqueous solution of lignosulfonates at the ratio of lignosulfonates: water, respectively, 1:(8-12) at intensive stirring for 20-30 mines, followed by drying the rubble at a temperature of 100-110°C to a constant weight.EFFECT: increasing the strength characteristics of limestone construction rubble while reducing the impregnation time and reducing energy costs.1 tbl, 3 ex
Blue product with hybrid energy-saving coating on glass substrate // 2642753
FIELD: chemistry.SUBSTANCE: multilayer coating on glass contains the following layers in order to increase the distance from the glass: the first layer of titanium dioxide of TiO2, the first contact layer of Zn-Al-O, the first silver layer of Ag reflecting IR radiation, the first covering layer of Zn-Al-O, an intermediate layer of Zn-Sn-O, the second contact layer of Zn-Al-O, the second silver layer of Ag, the second covering layer of Zn-Al-O, an external protective layer of Zn-Sn-O. The thickness of the intermediate layer is from 75 nm to 82 nm, and the thickness of TiO2 is from 8 nm to 14 nm. The ratio of the thickness of the layer of TiO2 to the thickness of the outer protective layer is in the range of 0.12 to 0.25. The aggregate thickness of two silver layers of Ag is such that the resultant surface resistivity of the product with a hybrid energy-saving coating does not exceed 4 Ohm/sq. The ratio of the thickness of the first silver layer of Ag to the thickness of the second silver layer of Ag is 0.5 to 0.8. The ratio of the thickness of the first covering layer to the thickness of the first contact layer and the ratio of the thickness of the second covering layer to the thickness of the second contact layer are equal to and not more than 0.42.EFFECT: reduction of heat losses during a cold weather, increase of translucence, decrease in the level of transmission of ultraviolet radiation.2 cl, 2 dwg
Silver product with hybrid energy-saving coating on glass substrate // 2642751
FIELD: chemistry.SUBSTANCE: coating comprises the first layer of titanium dioxide of TiO2 adjacent to the surface of the glass substrate, the first contact layer of Zn-Al-O, the first silver layer of Ag, reflecting infrared radiation, the first covering layer of Zn-Al-O, an intermediate layer of Zn-Sn-O, the second contact layer of Zn-Al-O, the second silver layer of Ag, the second covering layer of Zn-Al-O, an outer protective layer of Zn-Sn-O. The thickness of the intermediate layer of Zn-Sn-O is from 85 nm to 98 nm, and the thickness of the TiO2 layer is from 20 nm to 24 nm. The ratio of the thickness of the layer of TiO2 to the thickness of the outer protective layer is in the range of 0.56 to 0.75. The aggregate thickness of two silver layers of Ag is such that the resultant surface resistivity of the product with a hybrid energy-saving coating does not exceed 4 Ohm/sq. The ratio of the thickness of the first silver layer of Ag to the thickness of the second silver layer of Ag is 0.17 to 0.28. The ratio of the thickness of the first covering layer to the thickness of the first contact layer and the ratio of the thickness of the second covering layer to the thickness of the second contact layer are equal to and not more than 0.672. The product has a silver colour.EFFECT: reduction of heat losses during a cold weather, increase of translucence, decrease in the level of transmission of ultraviolet radiation.2 cl, 2 tbl, 2 dwg

ethod of creating water-resistant filling mass // 2642750
FIELD: mining.SUBSTANCE: method includes production of filling mixture by mill technology based on clinker and zeolite as binding agent, feeding it by gravity through a pipeline system and placing in mined-out space with its preliminary partial reinforcement. At that, successive supply and placement of two solutions is performed in mined-out space on level of an excavation located below pressure water-bearing horizon: first the solutions with water-resistant properties for height of not less than 1.5 m with embedding into the host rocks, and from the top of the base layer is the low-clinker under the roof of the excavation, then a drainage drift (DD) is developed in the filling mass on the contact with the host rocks along the contour of the water-resistant layer in its lower part and drainage holes (DH) are drilled out from the drainage drift into the filling mass above the water-resistant layer for complete interception and diversion of brines.EFFECT: provision of safe conditions for development of underlying mineral reserves due to complete interception and diversion of filtered brines.18 cl, 4 tbl, 3 dwg
Crude mixture for manufacturing fine-grained concrete // 2642749
FIELD: construction materials.SUBSTANCE: invention relates to the construction materials industry, in particular to the production of fine-grained concrete. Crude mixture for manufacturing fine-grained concrete contains, by weight: portland cement – 23.0–27.0; quartz sand – 60.0–64.0; superplasticizer C-3 – 0.6–0.8; technical lignosulfonate – 0.15–0.25; biocide – 0.0001–0.0002; synthetic vanillin – 0.001–0.002; water, heated to a temperature of 48–52 °C, is the rest.EFFECT: technical result is high frost resistance.1 cl, 1 tbl
Composition and method for preparing the foam converter in order to remove liquid from the bottomhole of gas and gas condensate wells // 2642743
FIELD: gas production industry.SUBSTANCE: invention refers to gas production industry and can be used in order to remove the water-gas-condensate mixture from the bottom of gas and gas-condensate wells. Composition contains surfactants, antifreeze and fresh water, as the surfactant it contains MORPEN, which is the mixture of water and oil-soluble alkyl sulfates and sodium sulfoethoxylates, as antifreeze it contains the mixture of polyethylene glycol and monoethylene glycol with the following ratio of components, WT%: MORPEN-24.0÷75.0; MEG-13.3÷40.0; PEG-4.0÷5.0; water - the rest. Method for preparing the composition comprises mixing all of its components at the room temperature until the uniform solution is formed.EFFECT: technical result is the creation of the foam agent with the high foaming capacity, which allows to ensure effective removal of water-gas-condensate mixture from the bottom of gas and gas condensate wells with different mineralization of borehole fluid, in the wide range of gas condensate content and retaining its physicochemical properties at elevated temperatures.2 cl, 6 tbl, 4 ex
Drying-type seam sealant with low water content // 2642742
FIELD: construction.SUBSTANCE: method for obtaining a granular composition of a drying-type seam sealant for joints of drywall panels, including the stages of: providing and mixing at least one binder and at least one filler, providing water, the content of which is 12-18 wt % relative to the total weight of the composition obtained, separately mixing dry and wet ingredients, combining the wet and dry ingredients and stirring them for 90 seconds with obtaining a granular mixture, 75-95% of which go through sieve No. 4. The composition of the drying-type seam sealant for joints of drywall panels, represented by a granular composition obtained by the above method, to which water is added as needed at a work site with obtaining a required consistency or viscosity. The invention is developed in the dependent claims of the formula.EFFECT: increasing the effectiveness of seam sealing.6 cl, 1 tbl
Product from chromium oxide // 2642739
FIELD: chemistry.SUBSTANCE: sintered refractory product consists of an aggregate bound by a matrix, and contains oxides in percentage by weight: more than 65 of Cr2O3, less than 35 of Al2O3, 1 or more of ZrO2, at least 20 wt % of which is stabilized in the cubic and/or tetragonal form, 0.1 or more of Y2O3, acting as a stabiliser of zirconium oxide ZrO2, less than 1.9% of HfO2, wherein the total content of chromium oxide, aluminium oxide, and zirconium oxide Cr2O3+Al2O3+ZrO2 is more than 90 wt %. The product contains a coactivator that is active or inactive as a zirconium stabiliser selected from CaO, MgO,TiO2, and mixtures thereof, wherein the total content of calcium oxide, magnesium oxide, and titanium oxide CaO+MgO+TiO2 is less than 6.0 wt % and more than 0.5 wt %, and more than 50 wt % of yttrium oxide and co-activator are present in the matrix.EFFECT: improving the stability of refractory materials for slag corrosion and temperature changes.24 cl, 16 ex, 2 tbl

ethod of multi-stage treatment of injection well bottomhole zone in terrigenous and carbonate formations // 2642738
FIELD: oil and gas industry.SUBSTANCE: method of multi-stage treatment of injection well bottomhole zone in terrigenous and carbonate formations includes hydrochloric acid treatment with acid composition of 0.5-1m3/m volume followed by pressing with aqueous solution of colloidal silicon dioxide nanoparticles or aqueous solution of surface-active substance of 2-3 m3/m volume; clay-acid treatment with clay-acid composition based on hydrochloric and hydrofluoric acids with 0.8 0.5 m3/m volume followed by pressing with aqueous solution of colloidal silicon dioxide nanoparticles or an aqueous solution of surface-active substance of 2-3 m3/m volume, treatment with hydrocarbon solvent of 0.5 m3/m volume and with clay-acid composition based on hydrochloric and hydrofluoric acids with 0.5 m3/m volume then by spraying aqueous solution of colloidal silicon dioxide nanoparticles or aqueous solution of surface-active substance of 2-3 m3/m volume. The following composition is used as acid composition, vol %: 30% hydrochloric acid 50-63; diethylene glycol 6-16; acetic acid 1-3; water-repellent agent based on amides, 1-3; corrosion inhibitor, 1.5-2; the rest is process water. The following composition is used as the clay-acid composition, vol %: 30% hydrochloric acid 48-60; hydrofluoric acid 1-4; diethylene glycol 6-16; acetic acid 1-3; water-repellent agent based on amides, 1-3; corrosion inhibitor, 1.5-2; the rest is process water. As aqueous solution of colloidal silicon dioxide nanoparticles, 1-2%- aqueous solution of colloidal silicon dioxide nanoparticles is used, containing wt %: colloidal silicon dioxide in acrylic acid, 32-40; propylene glycol monomethyl ether, 59.5-67.5; the rest is water. Aqueous solution of surface-active substance is 2-4% aqueous solution of surface-active substance containing, wt %: diethylene glycol, 1-3; hydrophobic agent based on amides, 0.5-2; the rest is process water. Solvent based on toluene fraction of straight-run gasoline or based on an aromatic hydrocarbon concentrateC10 is used a hydrocarbon solvent.EFFECT: increased efficiency injection wells, reduced time for implementation of the method, its simplification and reduced cost.2 cl, 7 dwg
Grouting mortar // 2642736
FIELD: mining; oil and gas production industry.SUBSTANCE: invention relates to mining and oil and gas production industry and can be used in development of mineral deposits by underground method and repair and insulation works in tunnels, oil and gas wells. Grouting solution contains 48–50 wt % of converter slag, 33–35 wt % of electric steel-smelting slag, 9–11 wt % of burned rock of mine dumps and slurry of spent electrolytes of acid batteries – the rest. Converter slag has the following composition, wt %: SiO2 35.43; Al2O3 8.51; Fe2O3 1.94; FeO 2.83; MnO 1.15; CaO 29.97 (including CaOfree 0.39); MgO 20.69; SO3 0.04; P2O5 0.14, and electric steel-smelting slag has the following composition, wt %: SiO2 26.63; Al2O3 5.33; FeO 0.95; MnO 0.37; CaO 55.55 (including CaOfree 0,71); MgO 9.68; S 1.41; P2O5 0.03; Cr2O3 0.05.EFFECT: technical result is wider nomenclature of cementless grouting mortars with increased durability of cement.1 cl, 3 tbl
Glass // 2642732
FIELD: chemistry.SUBSTANCE: invention relates to technology of silicates and relates to glass compounds, that can be used for making articles for decorative and art purposes,sorted crockery. Glass contains in %wt: SiO2 58.5–64.5; Al2O3 13.0–15.0; MgO 3.0–4.0; K2O 6.5–7.5; MoO3 6.5–7.5; CeO2 6.5–7.5.EFFECT: increase in chemical stability.1 cl, 1 tbl

Loose mixture to form thermal insulating layer // 2642702
FIELD: construction.SUBSTANCE: loose mixture to form a thermal insulation and levelling layer, in particular for the construction of floors, thermosetting at hydraulic hardening, wt %: from 5 to 30 of foamed polystyrene (EPS) in granular loose form, from 25 to 40 of water, from 40 to 60 of dry mixture of the mineral binder. The dry mixture of the mineral binder contains, wt %: 90 to 96 of white cement, 2 to 6 of silicic acid as a substance increasing adhesion between the EPS particles and the white cement, from 1 to 3 wt % of inactivated kaolin. The invention is developed in the dependent claims of the invention formula.EFFECT: obtaining a mixture with improved fluidity, creating from it a layer having improved physical properties in strength, thermal conductivity and sound insulation.23 cl, 2 dwg, 1 tbl, 4 ex
Reagent for removing formation condensation impure liquid from gas wells // 2642680
FIELD: oil and gas industry.SUBSTANCE: proposed reagent containing a non-ionic surfactant - PEG-4000 preparation, additionally contains sodium lauryl sulfate anionic surfactant and cementing substance - Camcell-700 at the following ratio of components, wt %: PEG-4000 65÷85, sodium lauryl sulfate 7÷22, Camcell-700 5÷13.EFFECT: efficient removal of condensation liquid.1 tbl
Crystal glass // 2642679
FIELD: manufacturing technology.SUBSTANCE: invention relates to silicate technology and crystal glass formulations that can be used to make household dishes. Crystal glass consists, in % by weight: SiO2 53.4–58.4; B2O3 16.0–17.0; CaO 4.0–6.0; MgO 1.0–3.0; ZnO 4.0–6.0; K2O 12.0–14.0; SeO2 1.0–1.6; TeO2 1.0–1.6.EFFECT: technical result is high heat resistance of glass.1 cl, 1 tbl
Water-soluble glue // 2642671
FIELD: chemistry.SUBSTANCE: group of inventions relates to an aqueous adhesive composition for gluing various paper products, as well as to a method of producing a substrate, on which a paper label is placed, to a pasted label having resistance to a mixture of ice water and a method of removing a paper label from the substrate. The aqueous adhesive composition includes emulsion polymer and epoxysilane in predetermined amounts, and the adhesive composition contains substantially no crosslinking reagent. The method of producing a substrate, on which the paper label is located, involves producing an adhesive composition and applying this composition to the paper label, then drying it, and applying a label with the adhesive to the substrate. The method of removing a paper label from the substrate includes fabricating the substrate and processing the label to remove it.EFFECT: stability in ice water and removability of labels.3 cl, 1 tbl, 4 ex
ethod for production of porous granular ammonium nitrate // 2642669
FIELD: chemistry.SUBSTANCE: method involves the introduction of a stabilizing additive into the ammonium nitrate solution with simultaneous neutralization with ammonia. Further, the solution is evaporated to form a melt and a dispersant and a pore-forming additive are added to the resulting melt. Granulation of the melt is carried out by dispersing in the cooling air flow and conditioning of the resulting granules. Nitrogen gas is used as the pore-forming additive.EFFECT: increased absorbing and retaining capacity of ammonium nitrate granules in relation to diesel fuel, increased static strength, increased thermal stability of granules.5 cl, 1 tbl, 10 ex

Improved cleaning from sulfur dioxide // 2642668
FIELD: chemistry.SUBSTANCE: method includes providing the off-gas of the melting furnace, separating sulfur dioxide from the exhaust gas to produce concentrated sulfur dioxide and exhaust gas for venting, mixing the concentrated sulfur dioxide with the fuel gas, heating the resulting mixture of fuel gas and sulfur dioxide by burning the fuel gas, contained in a mixture of fuel gas and sulfur dioxide, with oxygen so that the concentrated sulfur dioxide and fuel gas are reacted to form a mixture of gaseous products containing sulfur and hydrogen sulphide and removing most thereof, preferably substantially all of sulfur and substantially all of hydrogen sulfide from the gaseous product mixture, with the remaining mixture of gaseous products being post-burned prior to release into the atmosphere.EFFECT: invention provides a high efficiency of the sulfur extraction, the ability to use the remaining mixture of gaseous products, to reduce the fuel consumption and the absence of losses.26 cl, 2 dwg, 1 tbl

Composition of water-soluble coating for protecting nuclear fuel core surface // 2642667
FIELD: chemistry.SUBSTANCE: composition contains a polymeric resin based on methacrylic acid, 2-hydroxyethyl methacrylate and methyl methacrylate. The composition is a polymer resin containing 52-62 wt % of methacrylic acid, 34-42 wt % of 2-hydroxyethyl methacrylate, and 0.01-12 wt % of methyl methacrylate.EFFECT: production of the film coating having high strength and wear resistance that can be easily removed by washing with water.7 cl, 12 dwg, 8 tbl, 8 ex
Anti-corrosion compositions for zinc-containing primer coating, containing full glass spheres and conducting pigment // 2642665
FIELD: chemistry.SUBSTANCE: composition comprises a) a binder system selected from epoxy resin binder systems, polysiloxane-based binder systems, polyurethane-based binder systems, cyclized rubber binder systems, and phenoxy resin binder systems, b) zinc particles, c) uncovered hollows glass microspheres, and d) a conductive pigment selected from the group consisting of graphite, carbon black, aluminium-based pigments, black iron oxide pigment, antimony doped tin oxide, mica coated with doped antimony tin oxide, indium tin oxide, carbon nanotubes, fibres based on carbon black, graphite, and any mixture thereof. The said composition further comprises a solvent.EFFECT: improving the corrosion resistance of metal structures.17 cl, 9 tbl, 6 ex
Coating compositions cured by ultraviolet radiation and methods for their application // 2642663
FIELD: chemistry.SUBSTANCE: coating composition comprises: (a) functional urethane acrylate having 3 to 15 functionalities; (b) a photoinitiator; (c) an organic solvent and (d) a solvent-modified functional urethane acrylate oligomer. The functional urethane acrylate is present in an amount of 20 to 30 wt %, based on the total weight of the composition, and the said solvent-modified functional urethane acrylate oligomer is present in an amount of not more than 11 wt %, based on the total weight of the coating composition.EFFECT: coating composition can impart excellent rheological properties, as well as excellent gloss properties of the resulting film.21 cl, 6 tbl
Phosphate compounds as adhesion promotors // 2642661
FIELD: chemistry.SUBSTANCE: invention relates to application of a phosphate derivative to promote adhesion between bitumen and aggregates in an asphalt composition. The composition contains bitumen and a phosphate derivative. The phosphate derivative is obtained as a result of: i) etherification of a polyhydric alcohol containing at least three hydroxyl groups with a carboxylic acid containing 8-24 carbon atoms or a derivative thereof, wherein at least one, but not all hydroxyl groups undergo etherification, provided that if the polyhydric alcohol contains 5 or more hydroxyl groups, then at least two, but not all hydroxyl groups will be subjected to etherification, followed by introduction of the resulting ester into the reaction with a phosphating reagent; or ii) carrying out transetherification of triglyceride under the action of glycerine, followed by reaction with a phosphating reagent. Moreover, the said composition is not a "bitumen in water" emulsion.EFFECT: proposed additive increases bitumen adhesion to acidic and basic aggregates, and demonstrates good ecological characteristics.19 cl, 5 tbl, 4 ex
ethod of producing silicon carbide // 2642660
FIELD: chemistry.SUBSTANCE: silicon carbide is obtained from a charge comprising nanopowder of silicon-containing (SiO, SiO2, H2SiO3) carbon-containing (a carbohydrate of the general formula Cn(H2O)m, where n ≥12; m=n-1, a polyhydric alcohol of the general formula CnH2n+2On, where n≥2, aldehyde or ketone derivatives of polyhydric alcohols of the general formula (CH2O)n, where n≥3, components, prepared in deionized water, with the subsequent stepwise heating in three stages: up to a temperature of 145-195°C with the maintaining for 1.5-3 hours, up to 800-1000°C, with the maintaining for 0.4-1 h, and up to 1450-1650°C, with the maintaining for 1-1.5 hours.EFFECT: increasing the purification degree and the yield product of the order of 80-85% 3 etc.3 ex

Device for desalination of sea water // 2642658
FIELD: machine engineering.SUBSTANCE: device for desalination of sea water includes a body located inside and fixed on the frame structure with a suction valve, and a valve for discharging concentrate by a plunger pump, the movement of vertically arranged plunger working on reverse osmosis principle and containing a coiled flexible material that is twisted in shape of cylindrical pipe which is a reverse osmosis membrane, to the lower position passing beyond the limits of the body under the action of its weight, and lifting to the upper position is performed by a flexible coupling, one end of the lifting device is connected to the lower end of the plunger, and at the other end connected to a source of unidirectional intermittent motion in the form of sea wave energy converter.EFFECT: simplified design and improved reliability.8 cl, 1 dwg

Improved method of mass production of phosphoric acid with application of rotation furnaces // 2642651
FIELD: chemistry.SUBSTANCE: method involves the following steps: (1) primary processing of raw materials, (2) preparing internal areas of the granules, (3) forming composite pellets, (4) restoring composite pellets on heating method, and (5) hydrating and absorbing phosphorus.EFFECT: energy-saving, environmentally safe and highly efficient process, which allows to produce high-quality phosphoric acid.13 cl, 20 dwg

Disposable system for sterile obtaining of lipids and nucleic acids particles // 2642640
FIELD: pharmacology.SUBSTANCE: group of inventions discloses a system for sterile obtaining of lipids and nucleic acids nanoparticles and method for sterile obtaining of lipids and nucleic acids nanoparticles.EFFECT: group of inventions allows to obtain uniform lipid and nucleic acid particles by simple steps, reproducible and under aseptic conditions, and can be used to deliver this class of therapeutic molecules to target cells.23 cl, 13 tbl, 7 ex, 1 dwg
Oil-resin composition // 2642638
FIELD: chemistry.SUBSTANCE: oil-resin composition contains (in wt %) oxidized sunflower oil 30-35; ozonized petroleum resin modified with monoethanolamine, 15-20; solvent - the rest.EFFECT: obtaining of coatings with increased impact strength.1 tbl, 3 ex
Biodegradable composite material // 2642635
FIELD: biotechnology.SUBSTANCE: biodegradable composite material comprising a polymeric matrix based on waste formaldehyde resin and a filler comprising starch, yeast, casein glue, characterized by the filler containing sodium hydrogen carbonate in the following component ratio, by weight: waste phenol-formaldehyde resin SF-010 50.8-55.5, sodium bicarbonate 15.0-16.5, starch 11.0-13.0, casein glue 11.0-16.0, yeast 6.0-6.5.EFFECT: biodegradable composite material is proposed that efficiently utilizes phenol-formaldehyde resins and their wastes by biodegradation with the aim of reduction of the hazard class of the disposed substances, without adversely affecting the soil.1 tbl
 
2550853.
Up!