Nano-structures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units (B82B1)

B82   Nano-technology(3676)
B82B1                 Nano-structures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units(1295)

Optoelectronic device // 2642132
FIELD: physics.SUBSTANCE: optoelectronic device contains an emitter and a photodetector positioned in one plane at a certain distance from each other, ohmic contacts, wherein the emitter and the photodetector are made of consistently grown heteroepitaxial layers of dielectric and nanocrystalline silicon in the silicon substrate, and each silicon layer consists of p- and n-type sections with the sharp section borders.EFFECT: optoelectronic device according to the invention has a monolithic and small-sized structure, more reliable and less expensive.3 dwg

Terahertz-infrared converter for visualization of sources of terahertz radiation // 2642119
FIELD: physics.SUBSTANCE: converter consists of a base and transducers of terahertz radiation into infrared radiation. The base is made in the form of a matrix, transparent in the terahertz and infrared ranges of frequencies. Transducers are evenly distributed in the volume of the matrix and are made in the form of gold nanoparticles. The diameter of gold nanoparticles is determined by the formula D≈[(8/π)⋅(mAu/ρ)⋅(EF/hν)]1/3, where D is a diameter of gold nanoparticles, mAu - a mass of the gold atom, ρ - a density of gold, EF - Fermi energy of gold, hν - a photon energy of terahertz radiation.EFFECT: increasing the conversion efficiency and sensitivity of the device.2 cl, 3 dwg, 2 tbl
ethod of ice-cream production with nanostructured betulin // 2642099
FIELD: food industry.SUBSTANCE: method for producing ice cream containing betulin is offered. In the manufacturing process, a nanostructured additive is introduced, including betulin in sodium alginate, based on 2 g of nanostructured betulin per 1,000 g of ice cream.EFFECT: invention makes it possible to obtain ice cream without foreign smells and flavors, enriched with biologically active substances of vegetable origin.1 cl, 3 ex
ethod for ice-cream production with nanostructured girasol // 2642098
FIELD: food industry.SUBSTANCE: method for producing ice cream containing girasol is offered. In the manufacturing process, a nanostructured additive is introduced into the resulting product, including girasol in high- or low-esterified apple or citrus pectin, based on 2 g of nanostructured additive per 1000 g of finished ice cream.EFFECT: invention makes it possible to obtain ice cream without foreign smells and flavors and enriched with biologically active substances of vegetable origin.1 cl, 12 ex
ethod of ice-cream production with nanostructured extract of dry hedge rose // 2642093
FIELD: food industry.SUBSTANCE: method for producing ice cream enriched with dry hedge rose extract is offered. In the manufacturing process, a nanostructured additive is introduced into the resulting product, including dry hedge rose extract in sodium alginate, based on 2 g of nanostructured additive per 1,000 g of finished ice cream.EFFECT: invention makes it possible to obtain ice cream without foreign smells and flavors, enriched with biologically active substances of vegetable origin.1 cl, 1 ex
High-strength fine grain concrete // 2641813
FIELD: construction.SUBSTANCE: mixture for modified concrete containing portland cement, sand, nanosilica sol, white carbon, superplasticizer and water, characterized in that as a superplasticizer, a Linamix PK additive is used, with the following ratio of components wt %: sand: 66.3-67.8, portland cement 22-22.5, water 5.8-6.1, Linamix PK 3.38-3.45, microsilica 0.225-3, nanosilica sol 0.084-0.351, white carbon 0.045-0.158.EFFECT: obtaining a mixture for modified concrete of the brand by mobility P2 with a minimum consumption of cement.4 tbl
Ultrafast and ultrasensitive hybrid superconducting waveguide single-photon detector with low dark count rate // 2641621
FIELD: physics.SUBSTANCE: ultrafast and ultrasensitive hybrid superconducting waveguide single-photon detector with a low dark count rate includes a sensitive nanowire from a superconducting NbN film located on a nanowave guide Si3N4, and a protective dielectric-metallic coating consisting of an SiO2 dielectric layer and a layer of Al metal deposited over the nanowire.EFFECT: providing the possibility of reducing false triggering of a superconducting single-photon waveguide detector and increasing the sensitivity of the superconducting single-photon waveguide detector.3 dwg
ethod for obtaining nanosized fisher-tropsh synthesis catalyst and method of fisher-tropsh synthesis with its application // 2641299
FIELD: chemistry.SUBSTANCE: method for obtaining a nanosized catalyst of the three-phase Fischer-Tropsch synthesis comprising catalytically active iron nanoparticles involves dissolving the precursors - iron and potassium salts, in water, introducing the resulting solution into molten paraffin at a rate of 20-60 ml/h, forming the catalyst in situ directly in the reaction zone during the heat treatment of the catalyst components in an inert gas stream at a temperature higher than the decomposition temperature of the catalyst precursors and cooling for 1-6 hours in an inert current gas. The heat treatment time is not more than 15 minutes. The ratio of the catalyst components is, wt %: Fe - 0.5-1.0, K - 0.01-0.02, paraffin - the rest. Three-phase Fischer-Tropsch synthesis method includes obtaining aliphatic hydrocarbons from carbon oxide and hydrogen in the three-phase flowing slurry-reactor at an elevated temperature and a pressure in the presence of nanosized catalyst with a particle size of 0.7 to 4 nm, obtained in this way, when the molar ratio of carbon monoxide and hydrogen of 1:(0.5-3), a temperature of 240-400°C, a pressure of 20-30 ATM with the load on gas from 2 to 20 nl/hCatc⋅.EFFECT: when using the proposed composition and method of preparing a Fe-containing catalyst, a sharp increase in its activity is observed, as a result of which high process values can be achieved in smaller reactors, lower iron and potassium content in the catalyst, and a reduction in the heat treatment time, preventing of coarsening and agglomeration of the catalyst particles, higher catalyst productivity, higher selectivity for the formation of hydrocarbons.2 cl, 4 dwg, 1 tbl, 4 ex

ethod of obtaining supramolecular hydrogel // 2641111
FIELD: chemistry.SUBSTANCE: method of obtaining supramolecular hydrogels includes mixing an aqueous solution of L-cysteine with the silver acetate aqueous solution so that the concentration of L-cysteine in the mixture is in the range of 1.0 to 6.0 mmol, and the ratio of molar concentrations of silver acetate to L-cysteine in the mixture is in the range of 1.23 to 1.33, where the mixture is left in a dark place at room temperature for 4 hours for the formation of the L-cysteine-silver solution. Then, the mature L-cysteine-silver solution is mixed with an aqueous solution of sulfate with a cation from the series Na+, K+, Cu2+, Fe2+, Mg2+, Zn2+, Al3+, Ni2+, Co2+, Mn2+ at a concentration of sulfate in the mixture in the range of 0.075-0.750 mmol, after a certain time, depending on the concentration of sulphate and the type of cation, after which the liquid system becomes a gel.EFFECT: improved method.2 tbl, 6 dwg
ethod for treating soft tissue abscesses in experiment // 2639595
FIELD: medicine.SUBSTANCE: treatment method comprises lancing of the abscess, evacuation of the contents and laser destruction of intracavitary tissue sequester. Additionally, the cavity is filled with a combined 1% solution of zinc oxide nanoparticles and 1% solution of Eplan preparation daily until the abscess is healed.EFFECT: method provides stimulation of reparative processes of tissues, does not require special skills and expensive equipment, the method is minimum traumatic, it allows to achieve complete obliteration of the cavity on the 10th day of treatment.1 ex, 1 tbl, 3 dwg

Ophthalmological device with thin film nanocrystal integral circuits in ophthalmological devices // 2638977
FIELD: physics.SUBSTANCE: invention relates to an ophthalmological device that comprises of a first substrate liner containing an active optical device, a first thin film nanocrystal transistor, a first battery and a first conductive path. The first thin film nanocrystal transistor comprises of an n-type nanocrystal layer, the first battery is located near the first conductive path so that the first battery is in electrical connection with the first thin film nanocrystal transistor. The active optical device contains a liquid meniscus lens element comprising of two immiscible fluids to form a meniscus between them, whereby the active optical device is in electrical connection with the first battery and the first thin film nanocrystal transistor, and the active optical device is configured to change the focal characteristics of the ophthalmological device when applying an electric charge to change the shape of the meniscus. Hydrogel material surrounds or seals the first substrate liner.EFFECT: invention provides an ophthalmological device with a liner element, a thin film nanocrystal transistor, electrical interconnections and batteries.18 cl, 6 dwg
ethod for treating malignant new growths in experiment // 2638448
FIELD: medicine.SUBSTANCE: invention can be used in an experiment on animals with transplanted tumours to achieve a pronounced antitumour effect. The method includes the combined effect of magnetite nanoparticles (MN) and a low-intensity infra-low-frequency electromagnetic field. During the course of treatment, animals with tumours are administered with MN in the form of a magnetic fluid diluted with physiological saline to the MN concentration equal to 6.2 mg/ml and in a dose of 17.7 mg/kg, based on the weight of MN, subcutaneously to the zone spaced 1.5 cm from the tumour boundaries for 3 weeks, once every 3 days. In addition, a daily exposure to the animal's head is carried out for 4 weeks with infra-low frequency electromagnetic radiation in a repeated five-day cyclic regime. Every day, signals of three different frequencies are used - 0.03, 0.3 and 9 Hz, so that the exposure of the signals with a frequency 0.3 and 9 Hz is 1 minute, and the exposure of the signal with a frequency of 0.03 Hz during the cycle is 3, 4, 5, 3 and 4 minutes successively, with magnetic induction during a cycle varying from 3.2 to 0.7 mT.EFFECT: allows to achieve a pronounced antitumour and antistress effect.2 tbl
ethod for directed destruction of cancer cells // 2638446
FIELD: medicine.SUBSTANCE: their preliminary visualization is performed by introduction of a complex consisting of combined photosensitizer molecules, fluorescent nanoparticles fluorescing in the infrared spectral region, and biological recognition molecules into the object under study. The complex further includes one or more plasmon nanoparticles. At that, semiconductor fluorescent nanocrystals that fluoresce in the infrared region of the spectrum are used as fluorescent nanoparticles. Irradiation of cancer cells localization is continued in the optical absorption range of fluorescent nanoparticles for detection of a fluorescent signal from fluorescent nanoparticles and subsequent induction cancer cells destruction process.EFFECT: method provides non-invasive detection and directed destruction of cancer cells localized at great depth, with increased efficiency of visualization and destruction of cancer cells.16 cl, 1 dwg, 1 ex

Composition for producing nanocomposites with reconfigurable polymer matrix // 2638169
FIELD: chemistry.SUBSTANCE: composition comprises the following components in a ratio of wt %: 56-98 of the epoxy mesh polymer, 17.3-38.9 of dicarboxylic acid anhydride as a hardener, 1.8-3.8 of the interchain exchange catalyst, 1-40 of the inorganic filler. Zinc acetylacetonate is used as the interchain exchange catalyst. As an inorganic filler, spherical nanoparticles SiO2 or gallouzasite nanotubes are used.EFFECT: invention allows to obtain a polymer material with improved mechanical properties, capable of re-treatment and self-healing of cracks.6 cl, 3 dwg, 1 tbl, 6 ex
ethod for production of pharmaceutical compositions based on polymeric nanoparticles by microfluid technology // 2637653
FIELD: pharmacology.SUBSTANCE: method includes passage of an aqueous solution containing polyvinyl alcohol and an acetone or acetonitrile solution of etoposide or niklozamide and a biodegradable polymer in the form of a copolymer of lactic and glycolic acids with an intrinsic viscosity of 0.41-1.0 dL/g and molar ratio of monomer units of 25 and 75 to 75 and 25%, or a mixture thereof with the medical polymethylmethacrylate Eudragi through a flow-through microreactor made of borosilicate glass, preliminarily, an aqueous solution of polyvinyl alcohol is passed through a flow-through microreactor made of borosilicate glass at a concentration of 0.5 to 1% by volume in an amount of 1-100 volumes of the microreactor heated to a temperature of 55-65°C, followed by microreactor cooling to room temperature.EFFECT: stability of particle size distribution relative to the mean value and exclusion of the possibility of particles aggregation during their formation.2 cl, 5 dwg, 4 tbl, 2 ex
ethod for microscopic study of biological samples marked by phosphorescent probes in vitro // 2637630
FIELD: medicine.SUBSTANCE: multiplexed marking of a biological sample with phosphorescent material, their visualization and photoluminescence lifetime determination using laser scanning microscopy are performed. Nanosized anti-Stokes phosphors (NAF) with a size not exceeding 200 nm are used for multiplexed marking of a biological sample. NAFs are excited by a continuous IR laser with a wavelength of 980 nm. The image obtained using a laser scanning microscope is processed in two steps. In the first step, processing is performed along a slow scanning axis. In the second step, processing is performed along a fast scanning axis.EFFECT: increased sensitivity during visualization of phosphorescent nanoparticles, increased accuracy of determination of localization and of photoluminescence of lifetime discrete phosphorescent nanoparticles and their aggregates deposited on biological samples.3 dwg
Ap-conversion fluorescent nano-glass ceramics // 2637540
FIELD: chemistry.SUBSTANCE: fluorescent nano-glass ceramic consists of the following components, moll. %: SiO2 41.5-43.5; YbF3 1.0-2.5; PbO 12.0-14.5; PbF2 32.5-35.0; CdF2 7.0-7.5; Tb2O3 1.0-1.5 and Tm2O3 0.1-0.4. The field of application is optoelectronics, photonics, laser instrument engineering.EFFECT: producing transparent fluorescent nano-phase ceramic performing ap-conversion converting of infrared radiation into visible blue-green one at lower temperatures of the synthesis and thermal processing of glass.2 tbl, 1 dwg
arking additive // 2637334
FIELD: physics.SUBSTANCE: marking additive in the form of spherical particles contains a magnetic component and a marking component with the following ratio, wt %: magnetic component 2-98; marking component 2-98. The magnetic component comprises, at least, one component selected from the group consisting of ferrimagnetic iron oxides and/or ferrites with a spinel or garnet structure or particles of metallic Ni. The marking component contains a mixture of salts in the form of nitrates, acetates, chlorides, formates, or oxides, including solid solutions based thereon. The marking component comprises, at least, two elements selected from the group consisting of alkaline earth elements, lanthanides, transition metals, and post-transition metals.EFFECT: increasing the accuracy and reducing the analysis duration of objects containing a marking additive.12 cl, 3 tbl, 4 ex
ethod for photodynamic therapy // 2637279
FIELD: medicine.SUBSTANCE: microparticles are made from a copolymer of lactic and glycolic acids containing a photosensitizer. The obtained microparticles are added to the stem cells and their co-cultivation is carried out. After this, the stem cells are introduced to the subject with the tumour, and the tumour growth zone is exposed to light irradiation at a dose sufficient to completely or partially destroy the tumour.EFFECT: targeting effect with increased amount of the photosensitizer being transported, reducing the toxic effect of the latter on stem cells and eliminating systemic phototoxic damage.10 cl, 1 tbl, 8 ex, 2 dwg
Nanomodifier of construction materials // 2637246
FIELD: nanotechnology.SUBSTANCE: nanomodifier on a cement binder is described, comprising a mixture containing carbon nanomaterial (CNM), a filler and a plasticiser, wherein the CNM is introduced as an aqueous suspension that has been processed in an ultrasonic unit at an operating frequency of 16-25 kHz and a power of at least 100-500 W and containing potassium polititanate (PPT), CNM "Taunit" and polyvinyl pyrrolidone (PVP) with the following component ratio: potassium polititanate (PPT)-7-9×10-4%, carbon nanomaterial (CNM "Taunit") - 5-7% and polyvinyl pyrrolidone (PVP)- 1-1,6×10-3% weight of the cement binder.EFFECT: increasing the strength of concrete for compression and strength set at an earlier time, while simultaneous increasing the density, water resistance and crack resistance of construction composite.4 dwg, 3 tbl

Ap-conversion fluorescent nano-glass ceramics // 2636997
FIELD: chemistry.SUBSTANCE: ap-conversion fluorescent nano-glass-ceramics contains, moll. %: Eu2O3 1.0-1.5; SiO2 30.0-34.5; PbO 27.5-30.0; PbF2 21.5-25.5; CdF2 9.0-15.0; YbF3 1.5-2.5.EFFECT: creation of a transparent oxyfluoride nano-glass ceramics that has the property of converting infrared radiation into a visible orange and characterized by a high intensity of orange ap-conversion luminescence.2 tbl, 1 dwg

Two-component fibre containing nanowires for application in optically transparent composites // 2636729
FIELD: physics.SUBSTANCE: macrofibre for a composite product comprises a plurality of substantially unidirectional inner fibres, each having a final cross-sectional dimension of the inner fibre less than about 100 nanometres; the inner fibres are surrounded by a matrix material. The method of manufacturing of a macrofibre is also described.EFFECT: invention provides the creation of high-strength composite transparent products having a fibre configuration providing improved optical quality with reduced optical distortion.14 cl, 17 dwg

ethod for obtaining of antibacterial composition containing basic copper acetate // 2635505
FIELD: pharmacology.SUBSTANCE: composition including basic copper acetate, a mixture of copper acetate solutions with a concentration of 0.001-0.01 M and a solution of sodium hydrogencarbonate with a concentration of 0.0012-0.012 M in a molar ratio of 1:1.2 reagents containing a surfactant in the concentration range from 2- to 7-fold critical molar concentration of micelle formation.EFFECT: increased efficiency of the composition.2 cl, 5 dwg
ethod of protecting documents, securities or articles by using semiconductor filamentary nanocrystals // 2635212
FIELD: physics.SUBSTANCE: in the method, a label is placed in or into the security document, security paper or article containing semiconductor filamentary nanocrystals with the predetermined parameters that can be detected by using various detecting devices. The heterostructured filamentary nanocrystals thus obtained are made on the basis of a combination of materials with different forbidden bands, as well as structures with a combined dimension such as quantum dots inside the filamentary nanocrystals, which will ensure that these documents can be encoded by using them, as well as the simplicity of verification.EFFECT: increasing the security of these documents and articles and simplifying the procedure for the authenticity verification.4 cl, 2 dwg
Powder material for gas-thermal spraying of coatings // 2634864
FIELD: metallurgy.SUBSTANCE: invention can be used to protect the parts of the hot gas path of aircraft gas turbine engines (GTE), land based gas turbine units (GTU) and rocket engines (RE) against high temperatures, erosion and corrosion. The powder material has the general formula AXBYCZ (A=Nd, Sm, Gd, Dy, Y or mixtures thereof, B=Zr, Hf or mixtures thereof, C=O, 1.5⋅X+2⋅Y = 6.0…8.0; X:Y = 0.80…1.25, the particle size of the powder is 5…150 mcm, the bulk density of the powder is in the range 0.5…3.5 g/cm3, and the size of the crystallites (coherent scattering regions) is 1…300 nm. The powder material may also contain oxides of the following elements: SiO2 - up to 0.05 wt %, CaO - up to 0.1 wt %, MgO - up to 0.1 wt %, Fe2O3 - up to 0.1 wt %, Al2O3 - up to 0.1 wt % and TiO2 - up to 0.8 wt % or a mixture thereof.EFFECT: increasing resistance of thermal protection coatings to high temperatures, achieving a heat-shielding effect on the surface of the part.10 cl, 1 tbl

Delivery system for active means // 2634255
FIELD: medicine.SUBSTANCE: delivery system comprising an active agent in a polymeric material formed from a thermoplastic composition is described. Selective regulation with respect to the particular nature of the thermoplastic composition, as well as the manner by which it is formed, are used to form a pore network that contains a plurality of micropores and nanopores.EFFECT: achievement of such a multimodal pore size distribution can provide variation in the active means delivery rate for particular application.18 cl, 10 dwg, 11 ex

Detonation method of producing carbon particles // 2634008
FIELD: chemistry.SUBSTANCE: explosive with a detonation velocity of 6300 m/s or more is placed on the periphery of the starting material containing an aromatic compound with not more than two nitro groups, for example, dinitrotoluene, dinitrobenzene, or dinitroxylol. The explosive is detonated. The resulting carbon particles have a mass ratio of G/D 2.5 or more, where G is the carbon mass in the form of graphite, and D is the mass of the diamond.EFFECT: producing carbon particles containing nanographite and diamond, using a non-powdery, cheap and affordable starting material.10 cl, 5 tbl, 5 dwg

ethod for treatment of malignant new-formations by magnetic hyperthermia and pharmaceutical compositions for application in indicated method // 2633918
FIELD: medicine.SUBSTANCE: application of Zn-substituted magnetic nanoparticles based on manganese ferrite of the formula ZnxMn1-xFe2O4 (x=0-0.9), with average size of less than 40 nm, the Curie temperature ranges from 39 to 550°C, and the coercive force is 5 to 250 Oe. A pharmaceutical composition comprising these Zn-substituted magnetic nanoparticles and a pharmaceutically acceptable carrier is also provided. A method for malignant neoplasms treatment with magnetic hyperthermia, including the following steps (i) and (ii), is also proposed. Step (i) includes magnetic nanoparticles delivery to the tumour region in an effective concentration, selected from the group of magnetic metal oxides including Zn-substituted magnetic nanoparticles based on manganese ferrite of the formula ZnxMn1-xFe2O4 (x=0-0.9), with average size of less than 40 nm, the Curie temperature ranges from 39 to 550°C, and the average value of coercive force is 5 to 250 Oe. The step includes (ii) tumour region exposure to an alternating current (AC) magnetic field with an amplitude of 14 to 300 Oe and a frequency of 80 to 1000 kHz, where the exposure time of the said magnetic field at a temperature of 38 to 51°C is between 15 and 60 minutes. In addition, a method for experimental tumour cells damage by magnetic hyperthermia is proposed, comprising the following steps (i), (ii), (iii). At that, step (i) includes provision of magnetic nanoparticles selected from the group of magnetic metal oxides including Zn-substituted magnetic nanoparticles based on manganese ferrite of the formula ZnxMn1-xFe2O4 (x=0-0.9), with average size of less than 40 nm, the Curie temperature ranges from 39 to 550°C, and the average value of coercive force is from 5 to 250 Oe. Step (ii) includes addition of the said magnetic nanoparticles to the cell culture. Step (iii) comprises exposure of the said cell culture to a magnetic field of PT with an amplitude of 14 to 300°C and frequency of 80 to 1000 kHz, where the exposure time of the said magnetic field at a temperature of 38 to 51°C is between 15 and 60 minutes.EFFECT: increased effectiveness of treatment due to uniform heating of the tumour tissue with reduced undesirable phenomena as a result of concomitant or subsequent selective damage or at least partial destruction of tumour cells in the tumour region without damaging the healthy surrounding tissue.36 cl, 10 dwg, 4 tbl, 7 ex
Orthopedic implant from titanium and stainless steel with antiadhesive antibacterial coating // 2632761
FIELD: medicine.SUBSTANCE: orthopedic implant made of titanium and stainless steel with antiadhesive antimicrobial coating, made of titanium and stainless steel in the form of an intraosseous implant for large and small joints, as well as elements of fastening for the spine and long bones of patient's skeleton. The surface of an orthopedic implant of titanium and stainless steel, preliminarily ion-etched by argon ions is coated (by plasma spraying) by a two-component antiadhesive antibacterial biocompatible nanocoating with a thickness of 9 to 1180 nm containing spherical nanoparticles made of high-purity silver with a size of 4.5-9.5 nm with continuous protective carbon nanocoating from tetrahedral ta-C type diamond with a thickness of 0.4-1.2 nm deposited on their surface.EFFECT: reliable high antiadhesive antibacterial properties, reliable barrier for bacterial biofilm formation on the surface of the metal orthopedic implant during its operation, high biological compatibility in various physiological environments of the patient's body, reliable protection of the implanted metal orthopedic implant surface against periprosthetic infection.2 cl, 5 ex

ethod for manufacturing thermoelectric element for thermoelectric devices // 2632729
FIELD: electricity.SUBSTANCE: at first the received flexible tape is wound on a drum which is located in a vacuum chamber. Vacuum deposition of the thermoelectric material on its opposite sides is carried out. The tape is successively stretched by means of deflecting and tensioning rollers through the first heating zone and pulsed laser deposition of the thermoelectric material of the p-conductivity type to the heated area of one side of the tape. The tape is turned in the turn device and the tape is stretched through the second local heating zone to a predetermined temperature and pulsed laser deposition of the thermoelectric material of the n-conductivity type to the heated area of the opposite side of the tape. Then the tape is stretched through the zone of simultaneous formation of technological pattern on both sides of the tape by laser evaporation of the thermoelectric material on each of its sides. The tape is wound with the obtained two-sided technological pattern on the second drum.EFFECT: improvement of the method.2 dwg

Compositions and methods for therapeutic means delivery // 2632445
FIELD: pharmacology.SUBSTANCE: invention group is a nanoparticle for retroviral infection suppression, comprising at least one therapeutic agent and at least one surfactant, wherein the said nanoparticle is crystalline, wherein the said surfactant covers a crystal of the said therapeutic agent, wherein the said therapeutic agent is selected from the group consisting of atazanavir (ATV), efavirenz (EFV), indinavir (IDV) and ritonavir (RTV), wherein the said surfactant is an amphiphilic block copolymer, wherein the said nanoparticle is obtained by wet grinding or high pressure homogenization, and wherein the said nanoparticle contains at least 95% of a therapeutic agent; composition for retroviral infection suppression; method for HIV infection treatment or suppression.EFFECT: invention provides steady drug delivery to the serum and tissue and improved antiviral efficacy relative to the equivalent dose of the free drug.18 cl, 5 ex, 4 tbl, 25 dwg

ethod for preparation of sodium hydrocarbonate nanocapsules in konjac gum // 2632303
FIELD: pharmacology.SUBSTANCE: sodium hydroxide is used as a nucleus, and konjac gum is used as a nanocapsule membrane, with a core:membrane ratio of 1:1, 1:2, 1:3, 1:5, or 5:1. The method includes sodium hydrogencarbonate dispersion in a konjac gum suspension in butanol, in the presence of 0.01 g of E472c as a surfactant with stirring at 1200 rpm, then benzene is added, the resulting suspension is filtered and dried at room temperature.EFFECT: simplified and accelerated process of nanoencapsulation, reduced accompanying loss.2 dwg, 6 ex

ethod for producing nanoparticles of polysaccharides // 2632019
FIELD: chemistry.SUBSTANCE: method for producing nanoparticles of polysaccharides and their derivatives, partial oxidation thereof for the production of aldehyde groups and attachment of compounds with an amino group or another group with R-NH2, which react with an aldehyde group, in which a polysaccharide with a molecular weight of up to 1000 kD or its derivative is oxidized to produce aldehyde groups until an oxidation ratio of 5% to 55% of the sugar chains is produced, and then, at least, one nanomaterial that after attaching the aldehyde group, exhibits hydrophobic properties, is selected from the group consisting of: aliphatic or aromatic organic amines containing of 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids having from 4 to 20 carbon atoms, the hydrophobic amino acids, phosphatidylethanolamine, and, at least, one active substance containing, at least, one amino-, amido- or hydrazide group is added to a solution of the oxidized polysaccharide in water or in a mixture of water and organic solvent, the reaction is conducted at pH of 1 to 9, at a temperature of 10 to 100°C, and the total molar ratio of amino groups to aldehyde groups is of 20 to 0.5. A nanoparticle is also described.EFFECT: method for producing polysaccharide nanoparticles under mild conditions has been developed to provide covalent bonds of therapeutic compounds that are sensitive to an aggressive environment.20 cl, 2 dwg, 8 ex
Insert of hip joint endoprosthesis acetabular component made of polymeric nanocomposite material // 2631889
FIELD: medicine.SUBSTANCE: insert of the acetabular component is manufactured by thermo-pressing from a nanocomposite material, based on ultrahigh molecular weight polyethylene (UHMWPE) and multiwalled carbon nanotubes (MWNTs). MWNT introduction into UHMWPE is carried out by dry mixing using planetary-type mills. Multiwalled carbon nanotubes are introduced to increase product wear resistance in an amount of 0.1 to 2 wt %. The surface of the polymer liner well has grade 11 of roughness. The friction pair consisting of the acetabular component - endoprosthesis head made of the Co-Cr-Mo alloy, has the following characteristics: friction torque of 1.3 N⋅m; no visible traces of wear of the acetabular component friction surface, acetabular component lifetime is more than 10 years.EFFECT: invention allows effective treatment or prevention.2 dwg, 2 ex

ethod for production of resveratrol nanocapsules in konjac gum // 2631886
FIELD: pharmacology.SUBSTANCE: invention relates to the pharmaceutical industry, namely to a process for production of resveratrol nanocapsules in konjac gum, with konjac gum used as the nanocapsules coating and resveratrol used as the core at a coating:core ratio of 3:1 and 1:5. The method includes slowl addition of resveratrol to the kojac gum suspension in butanol in the presence of 0.01 g of E472c as a surfactant with stirring at 1000 rpm, then petroleum ether is added, after which the resulting suspension is filtered off and dried at room temperature.EFFECT: simplified and accelerated process of nanoencapsulation, reducing accompanying loss.2 dwg, 3 ex
ethod for chia seeds (salvia hispanica) nanocapsules production // 2631884
FIELD: pharmacology.SUBSTANCE: chia seed powder is used as a core, and sodium carboxymethylcellulose is used as the nanocapsule coating at a core:coating ratio of 1:1 or 1:3. The method consists in slow addition of the chia seed powder to a suspension of sodium carboxymethyl cellulose in petroleum ether in the presence of E472c as a surfactant, stirring at 1000 rpm, acetonitrile addition, after which the resulting suspension is filtered off and dried at room temperature.EFFECT: simplified and accelerated process of nanoencapsulation, reducing accompanying loss.1 dwg, 1 tbl, 3 ex

ethod for production of nanocapules of medicinal plants with sedative action // 2631479
FIELD: pharmacology.SUBSTANCE: method is characterized by 5 ml of valerian or motherwort tincture is added to a suspension containing 1, 3 or 5 g of gellan gum in petroleum ether, or 25 ml of motherwort or valerian tincture is added to a suspension containing 1 g of gellan gum in petroleum ether, or 10 ml of anomalous peony tincture is added to a suspension containing 3 or 5 g of gellan gum in petroleum ether, in the presence of 0.01 g of E472c as a surfactant, with stirring at 1300 rpm, the resulting suspension is filtered and dried at room temperature.EFFECT: simplified and accelerated process of nanocapsules production, increased weight yield.3 dwg, 11 ex
ethod for determining sizes of nanoparticles added to initial colloidal solution // 2630447
FIELD: measuring equipment.SUBSTANCE: method for determining the sizes of nanoparticles added to initial colloidal solution involves irradiating the solution with added nanoparticles by laser radiation. Measuring the current intensity of scattered radiation for a predetermined period of time and calculating the size distribution of nanoparticles in said solution Iirr(d) by the dynamic scattering method. Wherein the size distribution of nanoparticles in the initial solution Iph(d) is preliminary obtained by a similar method, the average photon counting rate is measured for said period of time for the initial solution Pph and the solution with added nanoparticles Pirr and the transmission coefficients at the wavelength of the laser radiation for the initial solution Tph and the solution with added nanoparticles Tirr are measured. The size distribution of the added nanoparticles is calculated as .EFFECT: simplifying determining the sizes of nanoparticles added to the initial colloidal solution.3 dwg

ethod for producing mesoporous xerogels and nanopowders in system zro2(y2o3)-al2o3 for carriers of catalysts at methane conversion into synthesis gas // 2629667
FIELD: chemistry.SUBSTANCE: invention relates to the synthesis of mesoporous materials, namely, to a method for producing mesoporous xerogels and nanopowders in the system ZrO2(Y2O3)-Al2O3 for catalyst carriers at the methane conversion into synthesis gas. The method is carried out by co-precipitating the original reagents with an aqueous ammonia solution of 0.05-0.15 M. As original reagents, 0.05-0.15 M aqueous solutions of ZrO(NO3)2⋅2H2O, Y(NO3)3⋅6H2O and Al(NO3)3⋅9H2O are used. When the hydroxides are co-precipitated in the reactor, a constant pH value is maintained in the range of 9.15 to 9.45 with a solution NH4Cl. After that, the co-precipitated hydroxides are dried and subjected to cryochemical treatment at a temperature of -20 to -30°C during the day. Then the obtained xerogels are heat treated at a temperature of 500-650°C to produce a metastable tetragonal solid solution based on ZrO2.EFFECT: production of highly disperse mesoporous xerogels and nanopowders, which are efficiently used as catalyst carriers in the development of catalytic systems.5 dwg, 2 tbl, 3 ex
Powder preparation with antibacterial and regenerative effects // 2629596
FIELD: medicine.SUBSTANCE: powdered preparation with antibacterial and regenerating effects contains copper nanoparticles with a dispersion of 30-40 nm, silver nanoparticles with a dispersion of 40-50 nm, zinc oxide and corn starch, the components in the preparation being in a certain proportion in wt %.EFFECT: broadening the spectrum of the drug, including for treatment of wounds with abundant exudation, infected not only by gram-negative and gram-positive bacteria, but also by fungi and their combination.2 tbl
Preparation for soft tissue regeneration with antibacterial effect // 2629595
FIELD: medicine.SUBSTANCE: invention is a preparation for the regeneration of soft tissues with antibacterial effect, characterized in that it has a powdery form and contains copper nanoparticles with a dispersion of 30-40 nm, silver nanoparticles with a dispersion of 40-50 nm and corn starch. The components of the preparation are in a certain ratio in wt %.EFFECT: increase of antibacterial activity in the treatment of purulent wounds, including with abundant exudation, exclusion of the possibility of secondary infection of the wound, pronounced draining and sorption properties.1 cl
ethod for processing ferrite-perlite steels // 2629581
FIELD: metallurgy.SUBSTANCE: method for processing ferritic-pearlitic steels includes equal-channel angular pressing at 20°C in a matrix with its channels crossing at 90° angle with two cycles of pressing along the "Vs" route with rotation of the blank by 90° after each pressing cycle. After pressing, subsequent low-temperature recrystallization annealing is carried out in the temperature range from 250 to 450°C during 1 hour with air cooling.EFFECT: increase yield point, ultimate strength and toughness of ferritic-pearlitic steels.1 cl

Device for generating micro-flow liquid flow in micro- and minichannels // 2629516
FIELD: physics.SUBSTANCE: in the channel, on one side, which is the surface of the fuel element substrate, longitudinal micro-grooves are provided or longitudinal bands of hydrophobic nanocoating are applied forming micro-stream fluid flows. The hydrophobic nanocoating that confines the micro-stream flow along the edges can be applied to the inner surface of all the walls of the mini-or microchannel or only to the surface of the substrate on both sides of the electronic fuel element.EFFECT: significant intensification of heat transfer in microsystems, stable operation both in terrestrial conditions and in zero gravity, including in all non-standard situations.4 cl, 6 dwg

Device for biologically active nanoaerosols generation // 2629353
FIELD: medicine.SUBSTANCE: generator of biologically active nanoaerosol contains a conductive body with dielectric flanges at the body ends and with through holes for nanoaerosol exit made on the body side surface; a dielectric insert pressed into the housing and equipped with means for access to the body inner side surface, a spray chamber in the form of a cavity in an ellipsoid dielectric insert with the major axis oriented along the body axis. At that, the flanges and the insert have opposing holes on one axis for introduction of the device for the drug solution and the neutralizing solution electric spraying into the spray chamber, and at least one opening for air supply to the spray chamber. The access means is made expandable to the body inner side surface, and the holes for nanoaerosol exit are evenly distributed along the perimeter of the body cross section near the means for access to the body inner side surface.EFFECT: invention makes allows to increase nanoaerosol generation efficiency and stability.12 cl, 5 dwg, 1 tbl
Production method of high-temperature superconducting film on the quartz substrate // 2629136
FIELD: electricity.SUBSTANCE: production method of high-temperature superconducting film on the amorphous quartz substrate involves applying of the three-layer coating into the pre-cleaned substrate surface. The first coating layer is formed from quartz with thickness 100-400 nm by magnetron spraying, the second layer is formed from zirconium dioxide, stabilized by yttrium with thickness 100-300 nm, the third layer is made of cerium dioxide with thickness 150-350 nm.EFFECT: provision of the possibility to eliminate the cracking of the high-temperature superconducting film.7 cl, 3 dwg

Holmium-manganese sulfide with giant magnetoresistance // 2629058
FIELD: physics.SUBSTANCE: holmium-manganese sulfide with giant magnetoresistance includes manganese and sulfur and further contains holmium at the following ratio of components, wt %: holmium 2.5-15, manganese 47.5-35, sulfur 50.EFFECT: invention allows to obtain a magnetic compound with a cubic lattice of NaCl type, which has a stable and repetitive effect of giant magnetoresistance in a wide range of temperatures and magnetic fields.4 dwg, 2 tbl
ethod for low invasive surgical stimulation of reparative osteogenesis of slowly consolidated distraction regenerates in combination with false connection of limbs long bones of limbs in case of soft scar tissues // 2628368
FIELD: medicine.SUBSTANCE: under the control of electron-optical transducer, a guiding drill rod is introduced through the slow-consolidating distraction regenerate area and the false joint area, through which a cutting tool in the form of a cannulated flexible shaft with a drill is then introduced, and a hole of a specified diameter is formed in the medullary canal of the long tubular bone using a replaceable cutting tools set with drills of increasing diameter. A nanostructured composite implant is inserted into the formed internal cavities through a hole of a predetermined diameter formed in the medullary canal of the long tubular bone in slowly consolidating distraction regenerate and the false joint area.EFFECT: method allows to reduce the time of distraction regenerate reconstruction into a full bone.2 cl
ethod for manufacturing bimetallic wire from different metals with cold drawing // 2628232
FIELD: metallurgy.SUBSTANCE: invention relates to the treatment of metals by pressure, in particular to the production of composite materials, and can be used to manufacture bimetallic wire of dissimilar metals. The zone, which consists of interconnected metals of the core and shell and carbon nanotubes, previously applied to at least one of the contact surfaces of the metals to be joined. Carbon nanotubes are applied during the preparation stage of the core contact surfaces and shell to the joint. Then, cold drawing is carried out to form a transition zone of the metals of the core, the shell and the mentioned nanotubes.EFFECT: increase uniformity of shell thickness over the length and cross-section.2 cl, 2 dwg

Composition having gcr-activity for determination of poly-aromatic heterocyclic sulfur compounds in hydrocarbon products, process of obtaining a composition, planar solid-phase optical sensor on its basis and method of obtaining it, use of sensor for poly-aromatic heterocyclic sulfur compounds analysis // 2627980
FIELD: chemistry.SUBSTANCE: composition having GCR activity for the determination of polyaromatic heterocyclic sulfur-containing compounds (PHSC) in hydrocarbon products is a chemotropic gel containing a polymer matrix with silver nanoparticles of anisotropic shape with a size of 10-90 nm and particles of graphene oxide with a size of 1-2 mcm. A process for the preparation of this composition comprises the synthesis of silver oxide, dissolution of the resulting suspension in an aqueous ammonia solution, mixing the resulting solution with graphene oxide, sequentially introducing silver nitrate and a reducing agent to produce silver nanoparticles in a suspension of 10-90 nm in size and introducing a polymer powder for the suspension transition into a hemotropic gel. A planar solid-state optical sensor includes a film having a thickness of up to 5 mcm obtained from a composition having a GCR-activity and containing on the surface π-acceptor compound. The PHSC analysis method includes applying a liquid sample to the planar solid-state optical sensor with the test compound.EFFECT: creation of planar optical sensors that allow using the method of giant Raman spectroscopy with high sensitivity, high selectivity, a wide range of detectable concentrations and high reproducibility and precision.24 cl, 6 tbl, 17 dwg

New materials and methods for dispersing nanoparticles in matrices with high quantum outputs and stability // 2627378
FIELD: physics.SUBSTANCE: first, luminescent nanoparticles are mixed, the outer surface of which is covered with two types of protective molecules, with a solid polymer precursor. Protective molecules contain the first and second functional groups. The first functional group is connected to the outer surface of the luminescent nanoparticle, and the second functional group provides a miscibility with the precursor of the solid polymer and/or the ability to react with it. The first functional group of the first type of protective molecules contains a metal ion having coordination functionality, and the first functional group of the second type of protective molecules has the functionality of a Lewis base. A polymeric article, for example a coating, a self-supporting layer or a plate transmitting light with a wavelength of 380-750 nm is produced from the resulting solid polymer with embedded luminescent nanoparticles. The lighting device comprises a light source and a light transducer including mentioned solid polymer. Any luminescent nanoparticles can be used in the invention.EFFECT: stability of nanoparticles and the colour purity are improved, the luminescence efficiency is increased and the lifetime is increased.16 cl, 8 dwg
 
2551000.
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