edicinal preparations containing material or reaction products thereof with undetermined constitution (A61K35)

A61K35/02 - From inanimate materials(132)
A61K35/06 - ineral oils(30)
A61K35/08 - ineral waters(225)
A61K35/10 - Peat; amber(142)
A61K35/14 - Blood(653)
A61K35/16 - Plasma; serum(376)
A61K35/18 - Erythrocytes(80)
A61K35/20 - ilk; colostrum(113)
A61K35/22 - Urine; urinary system(15)
A61K35/23 - Kidney(8)
A61K35/26 - Lymph; lymph-glands; thymus(139)
A61K35/28 - arrow; spleen(233)
A61K35/30 - Nerves; brain(138)
A61K35/34 - uscles; heart(56)
A61K35/37 - Digestive system(11)
A61K35/38 - Stomach; intestine(46)
A61K35/39 - Pancreas(70)
A61K35/407 - (74)
A61K35/413 - (38)
A61K35/42 - Lungs(21)
A61K35/48 - Reproductive organs; embryos(185)
A61K35/50 - Placenta; amniotic fluid(183)
A61K35/52 - Sperm(14)
A61K35/54 - Ovary; eggs; embryos(112)
A61K35/62 - Leeches(77)
A61K35/64 - Insects, e.g. royal jelly(436)
A61K35/68 - Protozoa(11)
A61K35/70 - (65)
A61K35/72 - (41)
A61K35/74 - Bacteria(921)
A61K35/76 - Viruses(92)
A61K35/78 - (2848)
A61K35/80 - (89)
A61K35/82 - (8)
A61K35/84 - (15)
Combination for acne treatment and method of its application // 2614392
FIELD: pharmacy.SUBSTANCE: combination for acne treatment, comprising an aqueous Gynura Procumbens leaf extract, and means containing non-activated platelets and white blood cells in their own blood plasma. A method of acne treatment by application of the above combination.EFFECT: combination and treatment method are characterized by high efficiency in acne treatment.2 cl, 2 dwg
ethod for myocardial revascularization in case of coronary artery disease // 2614196
FIELD: medicine.SUBSTANCE: combined effect on the myocardium is provided, including laser treatment and intramyocardial administration of autologous bone marrow stem cells (ABMSC). Through channels in the left ventricular wall in the myocardial ischemia area or areas are performed, with diameter of 0.3-1.0 mm and frequency of one channel per 1 cm2 of the left ventricle wall. Each channel is perpendicular to the left ventricle outer wall surface in the channel forming area. Channels are formed using the impact of CO2 laser, with a power of 800-1000 W and pulse duration of 20-50 ms. The pulse duration is chosen sufficient to form a channel by one pulse within the refractory period of the cardiac cycle. Then, 200 l of a solution containing 8.3 million of ABMSC is administered around each channel along its entire length using one injection. The needle is directed in the avascular zone at a distance of 1-2 mm from the outer channel wall. ABMSC is introduced when extracting the needle.EFFECT: reduction of intervention trauma, while maintaining its efficiency, reducing the volume of fluid injected with ABMSC, as well as application of one pulse to form a through channel in the myocardium, prevention of intraoperative complications and induced arrhythmia due to the laser pulse impact by forming channels in the myocardium within the refractory period of the cardiac cycle.1 ex
ethod for cancer adoptive immunotherapy // 2613884
FIELD: medicine.SUBSTANCE: tumor cells culture is contacted with natural killer cells and cytotoxic T-cells isolated from peripheral blood using 8 CD Micro Beads, human CD 56 and Micro Beads, human reagents. They are saturated with deuterium by incubation and culturing in the presence of interleukin-2 at a concentration of 10,000 IU/ml and heavy water concentration 7.7% at 37°C for 72 hours. Application of this method allows to increase the cytotoxic activity of lymphocytes responsible for tumor immunity, by deuterium saturation resulting in release of more stable oxidizing agents in an antitumor response.EFFECT: increased cytotoxic activity of lymphocytes in vitro.

Ways of acne treatment // 2613708
FIELD: medicine, pharmacy.SUBSTANCE: invention refers to medicine, namely to dermatology, and can be used to treat acne. To do this, plating of B. bifidum №1 suspension in saline solution ( 106 Cfu/ml) prepared from "Bifidumbacterin" with 100: 1 ratio into a sterile thioglycolic environment is performed, then it is incubated at (371±)°C during 48 h, the sterile gauze is impregnated with the resulting broth culture of bifidobacteria and applied on the affected skin for 30 minutes, the procedure is repeated 2 times a day.EFFECT: invention provides reduction in virulence of pathogens and persistent properties of acne due to the action of exometabolites and intact cells of lactic acid bacteria.3 dwg, 1 tbl, 3 ex
Bacteriophages production method // 2613423
FIELD: biotechnology.SUBSTANCE: method comprises culturing bacterial cells of host strain in the absence of extraneous microflora, phage lysate preparation and purification by precipitation and/or filtration. After 30-120 minutes after culturing initiation, at the optimum growth temperature for the culture of rapidly growing host strain, every 30-60 minutes, smears are made from the host strain culture from the surface of solid nutrient medium or from a liquid culture medium. The smears are stained with a solution of acridine orange in the final concentration of 0.001% to 0.02% or acridine yellow solution to the final concentration of 0.01% to 0.2%. The stained smear is microscoped in fluorescence microscope. Time is set for inoculating the mother bacteriophage at achievement in the stained smear of not less than 50% in relation to the total host strain cells proportion of orange acridine stained cells, fluorescing with orange or red shades, or the proportion of yellow acridine stained cells fluorescing with yellow or orange shades, at achevement of less than 10% in relation to the total host strain cells proportion of cells with non-uniform fluorescence that is paired pole adjoining cells in the form of rods with irregular or spherical cytoplasm fluorescent and spherical or ellipsoidal cells with slightly fluorescenting central section. Then mother bacteriophage is inoculated.EFFECT: stability of achieving high bacteriophage titer upon phage lysate production in a changing nutritive medium formulations, and increase in the range of variations of the indicator values of the host strain and bacteriophage culturing.11 ex
ethod of prevention and/or treatment of insulin resistance // 2613322
FIELD: medicine.SUBSTANCE: present invention relates to medicine, namely to endocrinology, and concerns prevention and/or treatment of insulin resistance. For that effective amount of Eubacterium hallii is introduced in form of pharmaceutical, food or fodder composition.EFFECT: method provides effective correction of insulin resistance due to higher level of Eubacterium hallii in small intestine.10 cl, 3 ex, 1 tbl
ethod for treating diseases of parodontium, periodontium and oral cavity mucosa // 2613299
FIELD: medicine.SUBSTANCE: invention relates to dentistry and can be used for treating parodontium and periodontium diseases, including generalised parodontitis, diseases of oral cavity mucosa, as well as for prevention of complications in dental implantation. Method of treating parodontium and periodontium and oral cavity mucosa diseases includes laser impact with wavelength of red range, in which movement of working tip of laser radiation along the area of pathological focus is realised repeatedly for 4-5 minutes on each jaw, by continuous passage, bringing to minimum time of stops 1-2 s in the areas of bands and frenula, and before laser impact hydromassage of gums and oral cavity mucosa is additionally performed with heated to 37-40°C natural mineral water under pressure 1.0-3.0 atm, with the following introduction into parodontal recesses of layer of 1-3 mm of composition of pearlescent pigment from fish scales and dental gel Gengigel of "Ricerfarma" company, Italy, production, in weight ratio 2:3.EFFECT: increased efficiency of treatment, prevention of recurrences, reduction of the level of rupture of small vessels and formation of hematomas, increase of reparation of parodontium, periodontium and oral cavity mucosa tissues, reduction of time of tissue healing, reduction of treatment terms.5 cl, 2 ex

Treatment method for chronical atrophic pharyngitis // 2613186
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to the medicine, particularly, to the otolaryngology, and may be used for the treatment of the chronical atrophic pharyngitis. For this purpose, an application anesthesia with 2% lidocaine solution is performed, autoplasma containing thrombocytes with the concentration of (351-451)109/l is administered into the submucous membrane of the pharynx, one 0.2-0.3 ml injection to the area of each lateral cushion, and two injections of 0.2-0.3 ml are administered either into each upper part or into each lower part of the pharynx. The procedures with 6 injections are performed in 4-6 days, whereupon, the luminotherapy is additionally conducted with the impact on the oropharynx with an open mouth, and/or on the left and right sides of the neck by the non-coherent, polarized, polychromatic, and low-energy light with the wave-length of 480-3,400 nm, flow density of the light energy per minute of 2.4 J/cm2, the degree of polarization of 95-98% during 10-12 minutes daily with 12-14 days.EFFECT: method of actuation of the regeneration process of the mucous membrane of the pharynx and improvement of microcirculation in tissues without side effects.3 dwg, 2 ex
ethod for treatment of irritable bowel syndrome with constipation, associated with bacterial overgrowth syndrome // 2613125
FIELD: medicine.SUBSTANCE: invention is intended for treatment of irritable bowel syndrome with constipation (IBS-C) associated with the bacterial overgrowth syndrome (BOGS). Mebeverine, 0.2 g, 2 times a day in combination with 30 ml of lactulose per day for 3 months are prescribed. Three courses of sequential therapy carried out without interruption and consisting of 0.4 g of rifaximin two times a day for 6 days, then 0.25 g of enterol 2 times a day for 10 days, then bifiform 1 capsule 2 times per day for 15 days, are prescribed simultaneously.EFFECT: method enables higher clinical effectiveness.1 tbl, 2 ex
Ischemic stroke treatment method // 2612981
FIELD: medicine.SUBSTANCE: for ischemic stroke treatment, brain bypass surgery is performed to create a microvascular or large-bore anastomosis. Stem cells are then introduced in the shunt directly to the ischemic area on the surgery side.EFFECT: selective stem cells delivery to the ischemic brain tissue, which creates favourable conditions for their further differentiation into nerve cells.

New bacteria and their extracts, and use thereof in dermatology // 2612790
FIELD: biotechnology.SUBSTANCE: group of inventions relates to biotechnology. Non-pathogenic strain of gram-negative bacteria is proposed, which is deposited in CNCM April 8, 2010 under number I-4290. Said strain is intended for use in treating or preventing skin inflammatory diseases. Bacterial extract is disclosed, which is obtained by culturing and lysis of above strain of bacteria. Bacterial extract has protein profile, which as shown by denaturation electrophoresis in polyacrylamide gel, includes 12 detectable strips, including three main strips corresponding to molecular weights in range between 30 kDa and 36 kDa, 41 kDa and 45 kDa, and 47 kDa and 51 kDa, respectively. Composition for treating skin inflammatory diseases is disclosed containing above strain and/or bacterial extract as active ingredient in effective amount and one or more dermatologically compatible fillers.EFFECT: group of inventions provides induction of cytokine IL-10, IL-12 and TNFα, inhibition of cytokine IL-4 and IL-6, activation of Langerhans cells, normalization of Th1/Th2 balance, reduction of expression of IgE, induction of formation of antimicrobial peptides and proteins hBD-2, hBD-3, S1007A, LL-31, PI3, RNase7 and NOD2.8 cl, 12 dwg, 9 tbl, 5 ex

Amyotrophic lateral sclerosis treatment using cells obtained from umbilical cord // 2612391
FIELD: biotechnology.SUBSTANCE: cells derived from the umbilical cord tissue, capable of self-renewal and proliferation, having the potential of differentiating into a neural cell phenotype, are injected.EFFECT: invention preserves motor neuron function for patient with amyotrophic lateral sclerosis.29 cl, 19 dwg, 25 tbl, 25 ex

ethod of nanocapsules production of dorogov antiseptic-excitor (dae) fraction 2 in konjac gum // 2612347
FIELD: nanotechnology.SUBSTANCE: method of obtaining of Dorogov antiseptic stimulator nanocapsules fraction 2 in konjac gum is characterized in that the Dorogov antiseptic stimulator fraction 2 is dispersed into the konjac gum suspension in benzene in the presence of 0.01 g of E472c preparation as a surfactant while stirring 1300 r/min, then 5 ml of methylene chloride are added, the precipitate is filtered off and dried at room temperature, and the core:shell ratio is 1:1 or 1:3.EFFECT: nanocapsules manufacture process simplification and acceleration and weight yield increase.3 ex, 2 dwg
Penicillium vulpinum micromycetes strain f-1523 with antibacterial activity on anthrax agent bacillus anthracis // 2612150
FIELD: medicine.SUBSTANCE: invention relates to medical microbiology and biotechnology. Penicillium vulpinum micromycetes strain, having antibacterial activity on anthrax agent Bacillus anthracis, is deposited in State collection of pathogenic microorganisms and cell cultures (GKPM-Obolensk) under registration number F-1523. Fugate of cultural fluid of micromycetes strain Penicillium vulpinum F-1523 in dose of 100 mcl shows maximum activity in relation to Bacillus anthracis STI-1 on second day of cultivation.EFFECT: invention provides use of Penicillium vulpinum F-1523 in suppressing development of anthrax agent.1 cl, 3 tbl, 3 ex
ethod for treatment of chronic endometrium inflammation // 2612087
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to gynecology, and can be used to treat patients with chronic inflammation of endometrium. For this purpose, intrauterine administration of 7.4 ml of polyvalent complex pyobacteriophage for 10 minutes is included in treatment, the course of treatment consists of 5 procedures once in two days, at that, the uterine cavity is preliminary irrigated for 12-15 minutes with a freshly ozonated saline generated using ozone and oxygen mixture with ozone concentration of 4500-5000 mcg/l, after intrauterine administration of polyvalent complex pyobacteriophage, a pyobacteriophage-saturated swab is placed at the rear vault of the vagina for 3-4 hours. On the day when no intrauterine procedures take place, the patient receives pyobacteriophage orally, by 30 ml twice a day on an empty stomach for 5 days.EFFECT: invention improves efficiency and safety of treatment by improving the functional state of the endometrium in the absence of side effects and complications, as well as its effectiveness, simplicity and affordability.2 ex
Production method of preparation injectable form based on sulfate chondroitin // 2612019
FIELD: medicine.SUBSTANCE: production method of injection drug forms of sulfate chondroitin (SC), comprising SC, benzyl alcohol dissolving in injection water, the process is carried out using nitrogen, preparation components are dissolved sequentially in a single reactor, with SC substance dissolved in injection water at 25±5°C, then benzyl alcohol is added, pH value is adjusted in the range of 6.0 to 7.5, and the volume is adjusted with injection water so that the final solution contains 90-110 mg/ml of sulfate chondroitin and 8.11 mg/ml of benzyl alcohol, the obtained mixture is subjected to sterilizing filtration, dispensed into ampoules and sealed.EFFECT: method eliminates multiple intermediate operations related to dissolving, sterilizing filtration, solution combination into a consistent flow chart, allows to obtain good quality drug and eliminate unreasonable costs during its manufacture.3 cl, 2 ex
Agent for treatment of arthrologic diseases // 2612014
FIELD: pharmacy.SUBSTANCE: agent comprises a Na-salt of chondroitin sulfate having an intrinsic viscosity (η), which is equal to 0.01-0.05 m3/kg, in the amount of 4-12 wt %, benzyl alcohol as a preservative in the amount of 0.8-1.2 wt % and water in the remaining amount. The agent may additionally comprise a stabilizer - sodium bisulfite in the amount of 0.09-0.11 wt %.EFFECT: desired therapeutic effect in the absence of side effects such as pain at the time of injection and appearance of induration at injection sites.4 cl, 2 tbl, 4 ex
ethod of treatment of subclinical mastitis in cows // 2612009
FIELD: agriculture.SUBSTANCE: invention relates to the field of veterinary medicine and is intended for the treatment of subclinical mastitis in cows in dry period. Mastitis is diagnosed in the dry period by determining the density of the clot formed when mixing the mammary secretion and 5% mastidine solution, and 0.8-1.2 probiotic based on Bacillus amyloliquefaciens bacteria is administered as a single dose intramammary to the affected parts of the udder, dissolved at a dose of 0.3 -0.35 g, at 1.3-1.9 at a dose of 0.5-0.55 g.EFFECT: invention for highly effective treatment of mastitis in cows in dry period, through the use of probiotic Vetom-3 based on Bacillus amyloliquefaciens of RNCIM B-10642 (DSM 24614).4 tbl, 2 ex
ethod for stabilisation of kerastoconus with therapeutic means // 2611951
FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to ophthalmology, namely to methods for conservative treatment of keratoconus with progressing course, etiology of which remains unclear. For this purpose method of keratoconus stabilisation includes preliminary instillation of 1% placenta hydrolysate solutionin dose 1-2 drops in eye. After that, exposure to electromagnetic field from inductors of apparatus "Polus-3", which are placed on closed eyelids, is performed. The following mode of apparatus impact is used: intensity - 1 degree, frequency 25 Hz, amplitude of magnetic induction 10 mT. Duration of procedure constitutes 8-10 minutes. Course of treatment includes 10 daily procedures.EFFECT: result of the method consists in resorption of central opacity, located on the apex of cone, which is accompanied with thickening of cornea "cut" on slit lamp, acquiring more correct ball-like shape by cornea, increase of vision acuity.2 ex
ethod for preparation of calcium-containing composition from sea urchins shells // 2611847
FIELD: medicine.SUBSTANCE: flat sea urchin Scaphechinus mirabilis shell - the waste of echinochrome A production and/or shell and needles of the fishing sea urchin Strongylocentrotus nudus - the waste of spinochromes A and E production are used as the raw material. The raw material is demineralized by concentrated phosphoric acid followed by addition of distilled water to produce dibasic calcium phosphate, which is then washed three times in 96% ethanol until complete discoloration. The alcoholic extract is separated by filtration and the desired product is dried at a temperature not higher than 50°C. The composition includes, by weight. %: 50.00-55.00 of dibasic calcium phosphate; 31.0-33.0 of protein; 9.0-10.0 of monosaccharides; 1.09-1.12 of macroelements (Fe, K, Mg, Na); 0.002-0.003 of microelements (Cr, Mn, Co, Ni, Cu, Zn); the rest is water.EFFECT: invention provides sea urchins processing waste recycling to provide a calcium-containing product.3 tbl, 3 ex
Cosmetic composition of fluid formed during hatching fish roe // 2611639
FIELD: cosmetics.SUBSTANCE: invention refers to cosmetic and pharmaceutical industry and represents a method for producing a cosmetic composition of fluid formed during the hatching of fish roe, including at least the following steps: (a) suspending of fish roe in minimal volume of water; (b) induction of synchronized fast hatching said caviar, preferably so, that hatching is terminated for less than 6 hours for more than 80% of embryos; (c) filtration of liquid, formed at hatching, from step (b) to obtain a composition, note here that said fluid filtration stage, formed at hatching includes a liquid filter formed at hatching, using a filter with pore size of at least 5 mcm and collecting of the filtrate; (d) treating the filtrate from stage (c) by means of ion-exchange chromatography, including: (1) loading of the filtrate to ion-exchange column, preferably on DEAE (diethylaminoethylic) column; (2) washing the column by suitable buffer, preferably buffered by irrigating solution with pH 7–9; (3) elution of column leucolectin polypeptides using first elution buffer or solvent, note here that preferably the first elution buffer comprises buffered flushing solution, additionally contains salt in concentration of 50 to 100 mM; (4) elution from column of remaining polypeptides using second elution buffer or solvent, at that, preferably second elution buffer comprises buffered flushing solution, containing salt in concentration of 500 mM to 2 M; (5) collecting eluate from step (4); (e) replacement of water in the eluate from step (5) on a cosmetically acceptable buffer; (f) filtering the solution obtained at step (e), using a filter with pore size of 0.15–0.30 mcm and collecting the filtrate; and (g) preparation of said cosmetic composition from the filtrate obtained at step (f).EFFECT: invention provides effective skin moistening and pilling of the stratum corneum.25 cl, 7 dwg, 1 tbl, 6 ex
ethod of obtaining biologically active product // 2611637
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry, namely to method of obtaining active powder from wastes of processing of antler deer raw material. Method consists in obtaining powder by extraction of press cake, obtained after fermentative hydrolysis of products of antler reindeer breeding, where as extractant applied is 40-50% solution of ethanol with ratio of alcohol solution: press cake 5:1-10:1, and extraction is carried out at temperature 35-50°C for 6-10 days with regular mixture mixing, with the following filtering, drying of extract and remaining press cake and their milling.EFFECT: method, described above, ensures extension of arsenal of means for obtaining biologically active products with higher rationality of application of antler reindeer breeding production.4 cl, 5 tbl
Hematogen // 2611636
FIELD: food industry.SUBSTANCE: hematogen contains black food albumin, starch syrup, condensed milk with sugar, granulated sugar characterised in that it additionally comprises chlorophyll-carotene paste of conifer needles, wherein the hematogene components are in a specific ratio by weight %.EFFECT: increasing the biological value and improving the organoleptic properties of hematogen, expanding the hematogen products range.1 tbl
Skin regeneration and rejuvenation method (versions) // 2611397
FIELD: medicine.SUBSTANCE: invention is a skin regeneration and rejuvenation method, characterized by administration of Laennek drug in an amount of 4-6 ml in 200-250 ml of 0.9% aqueous solution of sodium chloride, intravenously, 1-2 times per week, 3-5 procedures, or in an amount of 4-6 ml intramuscularly at VB 14, VB 15, E 5, E 6 points, 1-2 times a week, 2-5 procedures. Then lifting is performed after 2-3 weeks using the ultrasonic apparatus Altera Systems, 7 days after hardware exposure 3-5 procedures of Laennek drug intramuscular administration in an amount of 4-6 ml at points VB 14, VB 15, E 5, E 6 points is performed 1-2 times a week.EFFECT: intense skin renewal at the cellular level, tightening and smoothing of wrinkles, lifting and strengthening of the facial contours.2 cl, 2 ex
ethod for combined conditioning and hemoselection in one cycle // 2611396
FIELD: genetics.SUBSTANCE: invention discloses method of transplantation of hemopoietic stem cells (HSC) without irradiation including: (a) introduction to mammal subject of one or two doses of purine base analogue from 2 to 10 mg/kg of body weight, which is selected from 6-thioguanine (6TG), 6-mercaptopurine (6-MP) or azathiopurine (AZA) as stage of preliminary conditioning; (b) transplantation to subject of HSC donors lacking hypoxanthine-guanine phosphoribosyltransferase (HPRT) 48–72 hours after preliminary conditioning and (c) immediate administering of purine base analogue approximately from 1 to 5 mg/kg and extending administering approximately from 1 to 5 mg/kg of purine base analogue every 2–4 days for 2–8 weeks without envisaged period of recovery; where method is carried out in absence of preliminary conditioning by irradiation.EFFECT: disclosed method is carried out in absence of preliminary conditioning by irradiation, therefore subject requiring it is spared from toxicity induced by myeloablative radiation.18 cl, 6 dwg, 5 tbl, 2 ex
ethod for restoring uterus functions, impaired in case of acute or chronic inflammation // 2611375
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to field of medicine and deals with field of gynecology. Prescribed are: desensitising therapy, antibacterial therapy taking into account microbial factor, which is selected depending on type of pthogen and sensitivity to antibacterial medications and/or with prescription of anti-inflammatory therapy, as well as if necessary infusion-transfusion therapy, immune-correcting therapy, systemic enzyme therapy or hormonal therapy, on condition that Laennec is introduced intravenously by drop introduction in dose 8-10.0 ml of medication, diluted with 250 ml of physiological solution (0.9% sodium chloride solution) or 5% glucose solution, for 1 hour 30 minutes or 1 hour 20 minutes 2 times per week with course of 10 procedures, with the following introduction of Laennec in dose 6.0 ml 1-2 times per month in I phase of cycle intravenously by drop introduction or intramuscularly for 4-6 month.EFFECT: application of medication Laennec is claimed in complex therapy of recovery of uterus functions, impaired in case of acute and chronic inflammation.2 cl, 2 ex
Application of preparation laennek for reduction or elimination of manifestation of menopausal symptoms (versions) // 2611370
FIELD: medicine.SUBSTANCE: invention relates to field of medicine and gynaecology, namely to novel regimens of menopause therapy in women. Claimed are three versions of the method for reduction or elimination of manifestation of menopausal symptoms by intravenous drop introduction of preparation Laennek in combination with different preparations, belonging to group of substitutive hormonal therapy.EFFECT: increase of efficiency, improvement of tolerance to hormonal therapy in adaptation period and reduction of course of its administration.3 cl, 1 ex
ethod for bacterial diseases treatment for farm animals and birds // 2611351
FIELD: veterinary medicine.SUBSTANCE: method comprises administration of broad-spectrum antibiotic Tsiproventor together with cell-free probiotics Batsinil or Laktimet to animals and birds. Tsiproventor is applied as a daily dose of 0.3-0.5 g per 10 kg of animal weight or 0.4-0.5 kg per a ton of water. Cell-free probiotics are applied as a dose of 0.09-15.0 ml per head per day with drinking water at the rate of one therapeutic dose per 10-100 ml of water or 7.0-8.0 ml intramuscularly or intratracheally.EFFECT: method can reduce the time bacterial diseases treatment for farm animals and birds, reduce therapeutic doses of applied probiotics, increase the average daily gain of animals, eliminate the weight gain dynamics reduction periods for diseased animals, improve the quality of agricultural products produced.5 cl, 2 ex
Personal hygiene agent with acaricidal activity on mite demodex // 2611347
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry and represents personal hygiene agent with acaricidal activity on mite Demodex, containing water as solvent, foaming agent sodium laureth sulphate, preservative, biologically active component – birch tar, flavoring agent, consistence amplifier and extracts, characterized by, that device additionally contains detergent Chegina K 40GLO, as amplifier of foam and thickener Emanon XLf, emulsifier, thickener and fatter Amidet N and Amidet B 112, as preserving agent – Mikroker DN, Apricot perfume as flavoring agent, as plant extracts – extract of Chamomile, tickseed herb extract, tansy herb extract, verbena herb extract, wherein ingredients in preparation are taken in certain proportions, wt%.EFFECT: invention provides care of hair and human body, as well as high acaricide therapeutic effect on mites Demodex.1 cl, 2 ex, 1 tbl
ethod of treating demodectosis // 2611346
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry, namely to method of treating demodecosis. Method consists in application of care and prevention agents, means of local and systemic therapeutic agent. As agent for care and prevention and local therapy shampoo is used, containing following ingredients in wt%: sodium laureth sulfate 8.0–10; Chegina K 40GLO 1.5–2.0; Emanon XLf SAS 2.1–2.5; Amidet N 2.1–2.2; Amidet B 112, 1.0–1.5; Mikroker DH 1.4–1.7; Sodium chloride 2.0–2.5; Apricot perfume 2.4–2.6; Chamomile extract 2.9–3.1; tickseed herb extract 2.9–3.1; birch tar 0.28–0.32; tansy extract 0.28–0.32; verbena extract 0.28–0.32 and water to 100, and antibiotics and/or metronidazole are used as system agent. Shampoo is applied daily on problem skin areas, as well as hair and skin of face, neck and low neck zone, in external auditory passages rubbed in processed sections, kept 1–2 minutes, and then washed with warm water.EFFECT: invention provides obtaining of high therapeutic effect in form of reducing length of treatment due to higher acaricide effect.1 cl, 1 tbl, 2 ex
ethod for complex treatment of lumbar spine diseases // 2610795
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to vertebrology, and can be used for complex treatment of lumbar spine diseases. For this purpose, spine stretching sessions are performed using DRX9000 machine, while the patient in horizontal position with individual selection of the angle of lumbar spine inclination. Hardware stretching is carried out according to the scheme, consisting of ten daily sessions and ten sessions in a day. Each daily session of mechanical spinal stretching is preceded by 30-minute interstitial electrical stimulation by Magnon-PRB apparatus generating electric current at frequency 50 Hz and current intensity 5-20 mA; the course comsists of ten days. The first electrode is applied on the spines, and the second one - on projections of trigger points. What is also conducted is a drug therapy consisting of intravenous drop-by-drop introduction of Texamen 20 mg on the first four days, and on the following six days - alternate administration of mixed magnesia 5 ml and Actovegin 5 ml and mixed Spasgan 5 ml, Novocaine 5 ml, 0.5% Trental 5 ml and vitamin B12 5 ml.EFFECT: combined impact on the various elements of pathogenesis of spine diseases by means of multiple therapeutic factors, implementing synergistic therapeutic effect, to restore the volume of the intervertebral disc and create a sustainable healthy muscle memory state in paravertebral muscles.3 cl, 2 ex
Preparation, increasing production of nitrogen oxide by macrophages in vitro, based on humic acids of peat of tomsk region bogs and method for obtaining thereof // 2610446
FIELD: medicine.SUBSTANCE: invention relates to medicine and veterinary. The method for obtaining humic acids, increasing production of nitrogen oxides by macrophages in vitro, from peat of Tomsk region bogs includes crushing initial raw material, treating with exractant with mechanical stirring for 8 hours, sedimentation from solution with inorganic acid, separation of liquid and solid phases and drying the latter, with preliminary drying of peat at room temperature to air-dry state, crushing sieving through sieve with hole diameter 3 mm, with further extraction with sodium pyrophosphate with concentration 2.0-4.0 wt % in mass ratio peat: extractant 1:50-1:100 with constant stirring at temperature 25-27°C; after that extract of humic acids is treated with hydrochloric acid to pH 1-2, sediment of obtained humic acids is separated by centrifugation, after that washed from acidic to pH 7 medium and dried at room temperature. Application of humic acids from peat of Tomsk region bogs to increase nitrogen oxide production by macrophages in vitro.EFFECT: inventions make it possible to create effective technology of peat processing, which makes it possible to obtain water-soluble humic acids that possess capability to activate secretory properties in macrophages.2 cl, 3 tbl, 4 ex

ethods and compositions for use in cell therapy // 2610427
FIELD: biochemistry.SUBSTANCE: invention relates to biochemistry, namely to use of mesenchymal stem cells in method of treating immune-mediated inflammatory diseases, as well as for preparing drug for treating said diseases. Mesenchymal stem cells are used by their introduction into lymphatic system of individual. Additional aspects of invention relate to kit and method of treating immune-mediated inflammatory diseases.EFFECT: invention provides improved therapy with stem cells.20 cl, 1 dwg, 1 tbl, 1 ex
ethod of obtaining standard sample of sulphate turpentine // 2610421
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to method of producing standard sample of sulphate turpentine. Method of producing standard sample of sulphate turpentine, including water sampling, double extraction of sulphate turpentine with diethyl ether, ether extracts, obtained after extractions, are combined, bulb, in which water samples were extracted, is washed with diethyl ether, and obtained extract is added to extracts, obtained earlier, assembled ether extracts are washed with distilled water, then obtained ether layer is separated from water and dried with sodium sulphate, after which diethyl ether is distilled of produced sulphate turpentine, and standard solution is made by introduction of 0.00005–0.0001 grams of sulphate turpentine in 1.5 ml vial, it is diluted with methylene chloride to mark and content of components of sulphate turpentine is determined by chromatography mass spectrometry.EFFECT: method described above enables to obtain standard sample of sulphate turpentine.1 cl, 1 tbl, 4 ex
ethod of retrosclerofilling of eyes with dispersed biomaterial "alloplant" // 2610211
FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to ophthalmosurgery, and can be applied to increase efficiency of retrosclerofilling of eyes with dispersed biomaterial "Alloplant". For this purpose cut of conjunctiva, shifting of cut relative to underlying tennon membrane parallel to limb by 3-4 mm are performed. After that, cut of tennon membrane and introduction of dispersed biomaterial "Alloplant" in tennon space are realised, needle is extracted with the following spontaneous reposition of eye membrane and self-hermetisation of wound. Additionally pre- and postoperative period injection influence on biologically active points with biomaterial "Alloplant for acupuncture introduction", diluted in physiological solution in ratio: 30-50 mg of biomaterial per 0.3 ml of physiological solution, is performed. Injections are made in points VB1 (Tong zi liao), VB14 (Yang bai), V10 (Tian zhu), bilaterally, 0.5 ml in one injection, in sessions in quantity 1-10 s with 1-7 day periodicity.EFFECT: invention makes it possible to increase clinical efficiency of eye retrosclerofilling, realised in case of their chronic diseases, associated with hemodynamic malfunctions in organism.3 ex
ethod of ehf phoresis for resort rehabilitation of persons with degenerative changes in locomotor apparatus // 2609998
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to physical therapy, and can be used for resort rehabilitation of patients with degenerative-dystrophic changes in the musculoskeletal system. EHF-phoresis is performed using of mineral nitrogen and silicon low radon thermal water of Belokurikha. Applicators soaked in mineral nitrogen-silicon low radon thermal water of Belokurikha are applied daily on portions of skin in the lesion projection area and once in two days on the parathyroid projection. The areas are exposed to EHF radiation. EHF-phoresis on the lesion projection area is performed in the morning and EHF-phoresis on the parathyroid projection - in the afternoon. Treatment duration is at least 10 days.EFFECT: method of EHF-phoresis, which allows to improve the function of the musculoskeletal system due to targeted delivery of radon, nitrogen and silica to the body, improve microcirculation, activate regenerative processes, provide anti-inflammatory and analgesic effects.2 cl, 4 tbl, 2 ex
ethod of producing biopreparation with nootropic activity // 2609872
FIELD: pharmacology.SUBSTANCE: invention relates to pharmacology, namely to method of producing peptide biopreparation with nootropic action. Method of producing peptide biopreparation with nootropic action involves homogenization of male bee brood larvae in cooled isotonic solution of NaCl, boiling of homogenate of male bee brood larvae in order to denaturate proteins, removal of precipitate by means of paper filter and purification using membrane on ultra-filtration plant Vivaflow 50/200, making it possible to select peptides with weight up to 5 kDa.EFFECT: method described above enables to obtain peptide preparation with nootropic activity.1 cl, 2 tbl
ethod for prevention of larval stage of echinococcosis alveolaris // 2609858
FIELD: medicine.SUBSTANCE: invention relates to medicine and deals with method of prevention of larval stage of echinococcosis alveolaris, which includes introduction of cellular antigen from protoscolexes of Echinococcus multilocularis, where simultaneously with cellular antigen from protoscolexes of E.multilocularis biopreparation, which represents membranous fraction of epimastigotes Trypanosoma cruzi cells, is introduced subcutaneously.EFFECT: invention ensures development of protective immune reaction, which prevents from further infection.2 ex, 2 tbl
Calcium-phosphate cement for bone tissue regeneration (versions) // 2609835
FIELD: medicine.SUBSTANCE: described is calcium-phosphate cement (CPC) for bone tissue regeneration, which represents water-based paste, obtained as a result of mixing cement powder, containing β-tricalciumphosphate (β-TCP) and monohydrate monocalciumphosphate (MMCP), with hardening liquid, which contains water solution of magnesium sulphate and sodium phosphate, composition of non-collagenous bone tissue proteins and G1-glycoprotein, with specified component ratio (wt %). Also described is calcium-phosphate cement, which represents water-based paste, obtained as a result of mixing cement powder, containing β-TCP, MMCP and calcium sulphate hemihydrate, with hardening liquid, containing water solution of sodium phosphate, composition of non-collagenous bone tissue proteins and G1-glycoprotein, with specified ratio of components (wt %).EFFECT: increase of terms of cement paste setting, size of cement stone pores and pH values of cement paste at initial stages of its hardening.2 cl, 2 dwg, 2 ex
Lactobacillus acidophilus bacteria strain used to obtain fermented milk products // 2609653
FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology and can be used in dairy industry, medicine and veterinary science. Presented LIA-T-193 strain of Lactobacillus acidophilus bacteria possesses high acid-forming activity. Lactobacillus acidophilus strain is deposited in the ARRIAM under the registration number of RCAM01438. Strain can be used in production of “Ulcerine” acidophilic starter, also for preparation of acidophilous milk and cultured milk product. Can be used for feeding farm animals and poultry.EFFECT: invention enables to obtain cultured milk products with high antagonistic activity to undesirable microflora.1 cl, 3 ex
ethod for treating viral hepatitis or liver cirrhosis with "alloplant" biomaterial // 2609252
FIELD: medicine.SUBSTANCE: injection introduction of dispersed "Alloplant" biomaterial, dissolved in physiological solution in ratio 30-50 mg of biomaterial per 4.0-12 ml of physiological solution, is performed in dose 0.5-1.0 ml of solution per 1 injection. Treatment is carried out in sessions 8-10 in number per a course. The following prescriptions of points are alternated from session to session: the first session - paired points on posterior surface of trunk on the right and on the left of posterior-medial meridian - V18 Ganshu, V19 Danshu, V47Hunmen, V48 Yanggang, V49Yishe, and points on posterior-medial meridian - T8 Jin Suo, T9 Zhiyang; the second session - points on the anterior surface of trunk on the right of anterior-medial meridian - F13 Zhangmen, F14 Qimen, VB24 Riyue, VB25 Jingmen, RP19 Fuai and points on anterior-medial meridian - J5 Shimen, J12 Jungwan, J14 Tanjung, and so on with repetition after each session. Injections are realised with interval between sessions from 1 to 7 days and course duration from 2 to 4 weeks. Treatment is performed at the background of basic therapy.EFFECT: method makes it possible to increase treatment efficiency, which is achieved due to introduction of Alloplant into biologically active points in claimed sequence.2 ex

Lactobacillus paracasei 1 bacterial strain used for probiotic preparation production // 2608871
FIELD: biotechnology.SUBSTANCE: invention relates to microbiology and biotechnology. Strain Lactobacillus paracasei 1 has high antagonistic activity, high level of acid formation, improved adhesive properties, resistance to some antibiotic preparations and high rate of biomass accumulation. Strain Lactobacillus paracasei is deposited in Russian National Collection of Industrial Microorganisms under registration number VKPM V-11821 and can be used in production of probiotics.EFFECT: invention allows to normalize piglets intestinal microflora and enhance livestock livability.1 cl, 1 dwg, 7 tbl, 6 ex

Use of adipose tissue-derived stromal stem cells in treating fistula // 2608641
FIELD: biotechnology.SUBSTANCE: invention refers to cell technology. Described is use of adipose tissue-derived stromal stem cells in production of a pharmaceutical composition for treating fistula in a subject, wherein said adipose tissue-derived stromal stem cells are allogenic with respect to a subject to be treated.EFFECT: invention extends the range of products for treating fistula.28 cl, 7 dwg, 4 ex

Device and method for intraoperative lymphorrhea prevention in patients with cervical cancer after extended surgeries with pelvic lymph node dissection // 2607960
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncology. “Zhelplastan” is used for intraoperative lymphorrhea prevention in patients with cervical cancer with pelvic lymphadenectomy. Wherein drainage tubes are installed in retroperitoneum, ends of which are discharged into lower angle of postoperative wound through round ligament of womb or through vagina stump. Additionally, before installation of drainage tubes bed of removed lymph nodes is insufflated with sterile powder “Zhelplastan”, which is distributed with dry gauze swab along whole surface of wound pocket.EFFECT: method increases efficiency of lymphorrhea prevention and improving quality of life of patients due to reduction of duration and volume of lymphorrhea, reduced percentage of developing lymphatic cysts, reducing length of drainage, which promotes timely performance of further stages of combination treatment of cervical cancer patients.2 cl, 1 tbl

Strain of lactic acid bacteria, drug, food product, beverage, as well as fodder containing strain of lactic acid bacteria // 2607370
FIELD: biotechnology.SUBSTANCE: group of inventions relates to biotechnology. Strain Lactobacillus paracasei MCC1849 with high stimulating production of IL-12 activity.EFFECT: strain is used as ingredient of medicinal agent for immune stimulation, agent against influenza virus, food product, beverage, fodder and agent stimulating production of IL-12.8 cl, 2 dwg, 3 tbl, 3 ex
ethod of treating complications in patients with chronic nonspecific ulcerative colitis // 2607160
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to gastroenterology, and can be used for prevention of complications in patients with nonspecific ulcerative colitis. Method involves standard drug therapy and ozone therapy. Latter is performed by injections of 6 ml of ozonized autoblood at 1 ml in twin points V29, E36 and F8 daily for 10 days.EFFECT: method provides effective treatment of aggravation and stable remission of disease.1 cl, 2 ex, 1 tbl
ethod of producing modified alginate microspheres // 2606843
FIELD: biotechnology.SUBSTANCE: invention relates to investigation of biomaterials and tissue engineering, namely, to a method of producing modified alginate microspheres, involving liver decellularization, its mechanical slicing and further mechanical milling to produce microparticles of decellularized liver, that is fixed by covalent binding on preliminary prepared alginate microspheres, modified using modifying agents, such as hydroxysuccinimide (NHS) and hydrochloride N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (EDC). Invention provides high density of microparticles of decellularized hepatic tissue on the surface of modified alginate microcarriers and a strong covalent bond between them.EFFECT: proposed modified alginate microspheres can act as biodegradable container for biologically active substances and/or cells, as well as to protect the cells, encapsulated inside alginate microcarriers from act of recipient's immune system when implanted.7 cl, 3 dwg
ethod for producing polyploidized megakaryocyte and platelets // 2606764
FIELD: biotechnology.SUBSTANCE: invention relates to cell technology. Described are methods for producing polyploidized megakaryocyte and platelets, comprising forcing expression of a BCL-XL gene in megakaryocytes before polyploidization, said megakaryocytes are obtained by forcing expression of an oncogene such as MYC or a gene such as BMI1 in the cells at any differentiation stage from hematopoietic progenitor cells obtained not from ES cells, in megakaryocytes before polyploidization and cultivation and proliferation of the obtained cells, and cultivation the above cells.EFFECT: obtaining polyploidized megakaryocytes and platelets.14 cl, 24 dwg, 3 ex
ethod for preparation of biologically active substance, based on vermiculture // 2606693
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry, namely to method for preparation of low-molecular biologically active substance, based on vermiculture. Method for preparation of low-molecular biologically active substance, based on vermiculture, consists in fact, that collection of red californian worms into closed container is made and it is placed in refrigeration chamber, then they are washed with running water and put into succinic acid and cooled, then worms with acid are placed in low-temperature refrigerator, after that they are thawed, then they are crushed in blender and filtered, homogenized using high-pressure homogenizer, extract pH is determined and acidity regulator – aqueous solution of sodium bicarbonate is added and they are mixed with saccharose-gelatine medium, autoclaved, obtained solution is frozen and lyophilized under certain conditions.EFFECT: method, described above, enables to obtain more stable and effective immunotropic agent with anti-inflammatory effect.1 cl, 3 ex
Agent for stimulation of reparative osteogenesis // 2606257
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to use of preparation "Vinfar" as agent for stimulation of reparative osteogenesis in treatment of open fractures of extremity bones by intramedullary osteosynthesis.EFFECT: above solution enables stimulation of reparative osteogenesis, which leads to reducing length of callus formation and regeneration of bone in average by 7 days.1 cl, 4 dwg, 1 ex