Sulfur, selenium or tellurium and compounds thereof (A61K33/04)
A61K33/04 Sulfur, selenium or tellurium; compounds thereof(241)
FIELD: pharmacy.SUBSTANCE: method of agent production includes interation of raw arabinogalactan and selenium dioxide or selenious acid salt in a solvent followed by precipitation in ethanol or acetone, or other organic solvent capable of mixing with water. The peculiarity of this method is that the process is carried out at the temperature of 20-25°C, stable selenium nanoparticles size is 0.5-250 nm, and raw arabinogalactan or arabinogalactan specially purified from phenolic impurities is used as the raw materila, while water or dimethylsulfoxide, or formamide are used as solvents.EFFECT: soluble stable nanocomposites providing antitumor activity, in dry form.3 cl, 7 dwg, 11 ex
FIELD: pharmaceutics.SUBSTANCE: invention relates to chemical-pharmaceutical industry and medicine and describes a method for preparing the composition for parenteral administration, containing (wt%): 2-ethyl-6-methyl-3-hydroxypyridine succinate as an active component – 4.0–6.0; stabilizer – sodium metabisulphite – 0.015–0.045 and water as a solvent – up to 100. Invention can be used in medicine as a drug for treating and preventing various diseases and pathological conditions of a human body.EFFECT: composition is characterized by stability for three years, low toxicity, comparable with the solution of 2-ethyl-6-methyl-3-hydroxypyridine succinate without stabilizers, allows to implement the therapeutic action of the active substance without undesired secondary pharmacological activity of excipients.1 cl, 6 ex, 2 tbl
FIELD: veterinary science.SUBSTANCE: declared group of inventions relates to veterinary science and is applicable for treating bovine leukemia virus. Declared pharmaceutical composition for treating bovine viral leukosis, containing silver nitrate, lithium asparaginate, imidazole, sodium thiosulphate and non-steroid anti-inflammatory agent diclofenac in following ratio, wt%: silver nitrate 20, lithium asparaginate 20, imidazole 20, sodium thiosulphate 20, diclofenac 20. Method of treating bovine viral leukosis involves administering declared pharmaceutical composition in form of course of 5 intravenous injections in dose of 1.0 mg/kg of body weight every 96 hours with subsequent hematology control.EFFECT: use of declared group is highly effective for treating bovine viral leukosis.2 cl, 2 tbl, 2 ex
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, namely to restorative and preventive medicine, physiotherapy, cosmetology and can be used for recovery and rejuvenation. Method involves diagnostic computed capillaroscopy for detection of capillaropathy with subsequent course of capillarotherapy by presented scheme. Capillarotherapy during 90 days involves use of preparations containing components and minerals of the Dead sea. In bath volume of 100–300 liters with running water temperature of 36–38 °C 1 teaspoon of salt from each of four packages of “Quartet of the Dead sea salts” is dissolved. Bath is carried out for 15–20 minutes by Gesher technique. For this purpose it is proposed to lie in bath, relax, close eyes, visualize sea image or image of desirable target, then mentally start counting from 100 to 1 in slowly temp, concentrating only on account numbers, after completion of counting slowly open eyes, lie in bath for 5–10 minutes. After bath body skin is not wiped and on wet skin of body and face thin layer of regenerating cream “Solaris” is applied. Besides, Gonsin tea is introduced inside daily, brewing 1 tea package in 1 liter of water with temperature of 80–90 °C, 250 ml of room temperature 4 times a day 20 minutes before meals. Additionally during day no less than 1 l of drinking water without gas is introduced. Capsules “Oksin” or capsules “Goldsin” are introduced daily, 2 capsules a day in the morning after meals.EFFECT: method provides normalization of microcirculation, transcapillary exchange and metabolic processes in general, improved adaptive body reserves, harmonization of human psychoemotional state, which promotes treatment and prevention of developing diseases and premature ageing.7 cl, 3 ex
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to pharmacy, and concerns developing medical nasal sprays containing sea-buckthorn oil and sodium thiosulphate, and can be used for integrated treatment of rhinitis, tonsillitis, sinusitis. Preparation possessing anti-inflammatory, analgesic and wound-healing action contains, wt. %: sea-buckthorn oil or 15 % propolis oil extract - 3.0; sodium thiosulphate - 3.0; tween 80 - 1.0; medical glycerin - 10.0; purified water - up to 100.0.EFFECT: presented preparation possesses anti-inflammatory, regenerative action, as well as uniform release of active substances and manifested prolonged action, convenient for independent use by patients.3 cl, 3 tbl, 2 dwg, 5 ex
FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry and represents a composition for maintaining and/or restoring body during and/or after heavy physical activity, containing L-taurine, L-leucine, L-isoleucine, L-valine, extract of green tea leaves, yohimbine hydrochloride, spiny eleutherococcus rhizomes and roots extract, rhaponticum carthamoides rhizomes and roots extract, rhaponticum rhodiola rosea rhizomes and roots extract, bitter orange peel extract, riboflavin sodium phosphate, choline alfoscerate, calcium pantothenate, pyridoxine hydrochloride, folic acid, cyanocobalamin, biotin, nicotinamide, L-carnitine, beta-alanine, potassium orotate, methyluracil, inosine, caffeine, extract of leaves, blossom clusters and blooming sally rhizomes, creatine monohydrate, L-tyrosine, ascorbic acid, magnesium in the form of a bis-glycinate, copper in the form of a bis-glycinate, zinc in the form of a bis-glycinate, L-glutamine, thiamine hydrochloride, cholecalciferol 5000 ME, calcium malate, sodium dihydrogen phosphate, alpha-tocopherol acetate, L-selenomethionine, olive leaf extract, extract of peppermint leaves, leaf extract of goose-tongue, extract of common valerian roots and rhizomes, retinol palmitate and water, the ingredients of the composition are in certain ratio in milligrams.EFFECT: invention provides higher capacity of the body to withstand intensive physical activity, achievement of endurance and faster recovery of the body after the volume of training and heavy physical operation, adequate power supply during the whole period of intensive physical activity, accelerated recovery of the body after its completion, not resulting in depletion of nutrients in the central nervous system and skeletal muscles.10 cl, 3 tbl, 7 ex
FIELD: medicine; cosmetology.SUBSTANCE: invention refers to medicine, namely to cosmetology and dermatology, and can be used for treating acne. Perform complex therapy sessions carried out in sessions every second day. Thus 1st session includes cleansing the skin with antiseptic gel, vaporization, manual cleaning, processing with antiseptic lotion, darsonvalization performance, point and lymphatic drainage massage and the subsequent application of anti-inflammatory mask, and then - a protective cream or serum, cryomassage application. 2nd session after skin cleansing includes application of specified anti-inflammatory mask and subsequent application of mask with dissolving and exfoliating action, implementation of massage, darsonvalization and cryomassage performance and skin treatment at bedtime in the area of acne using therapeutic lotion. 3rd session after skin cleansing includes application of anti-inflammatory mask, antiseptic mask and darsonvalization and cryomassage performance locally on the affected elements. While at the 2nd session, after the application of mask with dissolving and exfoliating action, with its subsequent rinsing and drying of the skin perform therapeutic facial massage. To do this perform nine sequentially executed steps. Thus 1st stage includes stroking of the chin, cheeks, forehead. 2nd stage involves kneading the forehead, cheeks and chin. 3-ND stage includes pincer fulling of chin and cheeks, including along vertical lines, - from the middle of the chin to the nose wings; from the middle from beneath the angle of lower part of the jaw to the middle of the cheek; from the angle of the lower jaw bone - to the lateral surface of the cheeks. 3rd stage if finished using the "Snail" technique, consisting in the implementation of sixteen deep pinches from the lateral surface of the cheek in a downward direction, passing through the edge of the lower jaw, spinning along a spiral line to the middle of the cheek. 4th stage comprises circular grinding with circular and spiral movements. 5th stage includes forehead kneading along vertical lines. 6th stage involves light patting movements, “stacatto" on the forehead, cheeks and chin. 7th stage involves a deep vibration pinches, including ones along vertical lines of the lower part of the face. 7th stage if finished using the "Snail" technique. 8th stage is the same as 4th. 9th stage involves stroking; massage is done with light pressure on temples with both hands.EFFECT: method provides more efficient treatment, deep skin cleansing, elimination of inflammation, elimination of infection, elimination of toxins and impurities, full recovery of skin functions by achieving a stable therapeutic effect, improvement of blood circulation in the subcutaneous capillaries, acceleration of metabolic processes in the skin affected by acne due to the deeper and more intensive effect in conducting therapeutic massage.3 cl, 5 ex
FIELD: medicine.SUBSTANCE: invention relates to method of producing substance for destruction of microvasculature of removed skin formation. Proposed method consists in fact that in glass container salt of benzylpenicillin is introduced selected at 1…2 million units and 80-90 mg of plasticised polyvinyl chloride, reduced volume to 10 ml with 60-65 % solution of sulphuric acid, and after removal of broken down polyvinyl chloride solution is additionally added with 5…10 mg of propolis, reducing total volume of final product to 10-15 ml with 60-65 % solution of sulphuric acid, tightly sealed glass containers, mixture is held in darkness at temperature of 20…25 °C until complete dissolution of propolis.EFFECT: use of method allows to preserve therapeutic properties of substance for one year.1 cl, 2 ex
FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, namely to a method of producing an extract of castoreum and biologically active additive of it. Method of producing an extract of castoreum for production of biologically active food additive with bracing, tonic, immunomodulatory action, involving bucking of pre-dried castoreum up to homogeneous fine powder, then powder is extracted with water solution of ethyl alcohol, mixture is maintained without access of light, extract is separated by filtration, extraction is carried out at least 3 times, at that, the last extraction is carried out using ultrasound, then extracts obtained after each filtration, are mixed and boiled out under certain conditions. Biologically active additive (BAA) to food - in the form of a tablet. Biologically active food additive - in the form of capsules.EFFECT: method described above allows to produce BAAs, having bracing, tonic and immune modulating properties.3 cl, 1 tbl, 3 ex
SUBSTANCE: invention relates to pharmaceutical industry and represents use of antibacterial and antiviral pharmaceutical composition, having pronounced anticancer, antibacterial and antioxidant properties, containing silver nitrate, hexamethylenetetramine, sodium thiosulphate, alpha-aspartic acid or asparagine, nicotinic acid and water, wherein ingredients of composition are taken in a certain ratio, wt%, and also represents use of antibacterial and antiviral pharmaceutical composition, having pronounced anticancer, antibacterial and antioxidant properties, containing silver nitrate, hexamethylenetetramine or imidazole, alpha-aspartic acid or asparagine, nicotinic acid, imidazole-containing compounds of platinum cis-[Pt (NH3)2Im2]Cl2 or CIS-[Pt (NH2OH)2Im2]Cl2 and water, wherein ingredients of composition are taken in certain ratio, wt%.
EFFECT: invention widens range of agents for said purpose, wherein claimed composition can be used as an integral part or as independent preparation, having therapeutic and preventive properties, preventing damage to cells by free radicals, improving body defences and promoting tissue regeneration.
2 cl, 2 ex, 1 tbl
SUBSTANCE: invention relates to method of producing nano capsules of sulphur. Above method is characterized by, that sulphur is dispersed into suspension of sodium carboxymethyl cellulose in petroleum ether in presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid, then adding ethyl acetate, obtained suspension of nano capsules is filtered and dried at room temperature, wherein ratio nucleus:polymer in nano capsules amounts to 1:3 or 3:1 or 1:1.
EFFECT: invention provides simplifying and accelerating process of producing nano capsules and increases mass output.
1 cl, 1 dwg, 4 ex
SUBSTANCE: invention relates to encapsulation. Described is a method of producing nanocapsules of sulphur. According to method disclosed herein, sulphur is added to sodium alginate suspension in butanol in presence of E472c preparation while mixing. Precipitator - sulphuric ether - is added. Obtained suspension of nanocapsules is filtered and dried. Process of nanoencapsulation is performed at 25 °C for 20 minutes.
EFFECT: invention provides implementation of purposes.
1 cl, 2 dwg, 3 ex
FIELD: medicine.SUBSTANCE: invention relates to dermatovenerology and may be used for local treatment of papulo papulopustular shape rosacea. Method involves desintoxication therapy, which includes antihistamine and sedative druges in combination with local pharmacotherapy. Local therapy is conducted by following procedure: on clean face on affected areas are applied 5 % sulphuric ointment 2 times a day in morning and in evening for 3 days, then 10 % sulphuric ointment 2 times a day in morning and in evening for 3 days, then 20 % sulphuric ointment 10 days 2 times a day in morning and evening, then gel Azelik 15 % aqueous 2 times a day on dry clean face in morning and in evening for 3-4 months, then 1 time a day in morning for 3-4 months, throughout course for washing in morning and evening, foam is used for washing Setafil® Dermacontrol™ and wetting agent for face Setafil® Dermacontrol™ SPF30 1 time a day in morning after washing with foam.EFFECT: use of invention improves clinical effectiveness by reducing number of recurrences and complications.1 cl, 1 ex
FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry and represents a anti-osteoporotic agent containing trace elements in the form of borate and manganese salt and vitamin D3, characterised by additional introduction of natural conformers of amber or fumaric acid in the form of acid and ammonium salts of calcium, magnesium and zinc in aqua-chelate form, microelements in the form of fluoride and selenate as sodium or potassium salts, calcium caseinate enriched with glycine and mono-L-glutamate sodium; at that, components of the agent are taken in certain proportions, mg/dose.EFFECT: invention provides for expansion of the range of medications for treatment of osteoporosis, improvement of therapeutic effect, as well as elimination of side effects and recurrences.6 cl, 4 dwg, 3 tbl
FIELD: veterinary.SUBSTANCE: invention is intended for the treatment of eosinophilic pneumonia in case of heartworm infestation. Apply prednisolone in dose of 0.18 mg / kg intramuscularly, 2 times a day for 5 days. Sodium thiosulfate 30% at 0.3 mg/kg iv 1 times a day for 10 days. Cefotaxime 15 mg/kg intramuscularly, 2 times a day for 10 days. Ivermek 0.5 mg/kg IM once. 7 days after ivermek, prescribed is levamisole 75 in increasing doses intramuscularly within 7 days of 1.5 mg/kg, 2.5 mg/kg, 5.0 mg/kg, 7.5 mg/kg, 7.5 mg/kg, 7.5 mg/kg, 7.5 mg/kg.EFFECT: claimed invention improves the efficiency of the treatment of dogs with eosinophilic pneumonia in case of heartworm infestation.1 cl, 1 tbl, 1 ex
FIELD: medicine.SUBSTANCE: tabletted dietary supplement containing iodine and selenium, the rest - other substances, contains iodine and selenium in mass ratio approximately 2:1 in the iodine content of 100-400 mcg.EFFECT: simultaneous intake of iodine and selenium within normal daily requirement and in ratio providing balanced production of thyroid hormones by a thyroid.2 cl
FIELD: veterinary medicine.SUBSTANCE: 5 ml of 1% solution of sodium selenite containing 1 ml of alcoholic extract of Acanthopanax sessiliflorum per 100 ml of solution is administered to non-milking intramuscularly with. The solution is administered once for 30-20 days prior to proposed calving.EFFECT: invention enables to improve the birth of live calves and their safety to one month of age, and to reduce the duration of the service period.1 tbl
FIELD: medicine.SUBSTANCE: antioxidant composition containing retinol acetate in an amount of 1,650 International units (0.568 mg) - 3,300 International units (1.135 mg), α-tocopherol acetate 7.5-10 mg, ascorbic acid 35-50 mg, thiamine hydrochloride 0.581-1.0 mg, riboflavin 1.0-1.27 mg, pyridoxine hydrochloride 2.5-5.0 mg, folic acid 50-100 mg, lipoic acid 1-2 mg, ferric sulphate 2.5-5.0 mg, copper sulphate 75-400 mcg, methionine 50-100 mg, selenium 25-50 mcg is prescribed across contraception. The antioxidant composition is administered once a day, orally after meals over a period of 30 days. After 30-day pauses, the therapeutic course is repeated five times.EFFECT: invention enables recovering the antioxidant status in the patients, reducing the risk of thromobosis accompanying prolonged hormonal contraception.2 tbl, 2 ex
FIELD: medicine.SUBSTANCE: invention refers to veterinary science. The method provides administering E-Selen 0.04 ml/kg or Selenolin® 0.008 ml/kg of doe's body weight intramuscularly six or seven days before a mating. One day before the mating, Monklavit-1, iodine polymer preparation 2.0 ml per head dissolved (1:1) in 5% glucose is given per os with using a needle-free syringe.EFFECT: using the dosage schedule of the microelements (iodine and selenium) enables the thyroid functional and organic changes ensuring the thyroid homeostasis and increasing the production yield of breeding rabbits from the first kindling that is expressed in increasing the number of infant rabbits in a kindle, preserving and activating a body weight yield.2 tbl
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, namely to selenium nanocomposites of natural hepatotrophic galactose-containing polysaccharide matrixes, representing water-soluble orange-red powders containing zerovalent selenium (Se0) nanoparticles sized 1-100 nm in the quantitative content of 0.5 - 60 wt %, possessing antioxidant activity for treating and preventing redox-related pathologies, particularly for treating toxic liver damage, to a method for producing and to an antioxidant agent containing the above nanocomposites.EFFECT: invention provides the targeted agent delivery to liver cells, as well as higher agent accessibility and lower toxic action of selenium.7 cl, 11 ex, 4 tbl
FIELD: medicine.SUBSTANCE: method is implemented as follows: preparing a mixture 1 by adding 0.5M aqueous solution of selenious acid 250 mcl in PEG 400 8 ml, mixing thoroughly in a magnetic mixture at min. 750 rpm with pH of the given mixture 7.55; that is followed by preparing a mixture 2 by adding 0.5M aqueous solution of hydrazine hydrochloride 250 mcl in PEG 400 8 ml, mixing thoroughly in a magnetic mixture at min. 750 rpm with pH of the given mixture 0.68. The mixture 1 is added to the mixture 2 by mixing thoroughly drop by drop. The prepared solution is dialysed against distilled water with removing PEG 400 and hydrazine hydrochloride; the surplus water is distilled off in a rotary evaporator at 60 rpm and 70°C. The prepared solution is added with a low-molecular compound specified in a group of: gentamicin, hexamethylene tetramine, methionine, cephalexin, indole-3-carbinol; pH is reduced to 7.2-7.4. The components are mixed in an amount to provide their content in the agent, wt %: biologically active low-molecular compound 0.001-5.0; selenium 0.0001-1.0; water up to 100.EFFECT: simplifying the technology.2 tbl, 3 ex, 1 dwg
FIELD: veterinary medicine.SUBSTANCE: method comprises subcutaneous administration of antibiotic preparation enroxyl 5% at a dose of 0.1 ml/kg daily one time a day for 7 days and intramuscular administration of homeopathic preparation ovarinin at a dose of 1 ml/kg one time for 4 days, 4-fold.EFFECT: use of the invention enables to increase the efficiency of treatment, to reduce treatment time and to restore reproductive function of dogs.2 tbl, 1 ex
FIELD: medicine.SUBSTANCE: group of inventions refers to veterinary science and is applicable for treating bovine mastitis. What is declared is a nosode for producing a preparation for treating bovine mastitis. That involves taking mastitis milk 1 ml with clinical signs of purulent-catarrhal mastitis, filling it 70° alcohol 9 ml to produce a homogenous solution; the produced solution is diluted to "Д6" with 70° alcohol. What is also declared is a preparation for treating bovine mastitis containing an aqueous-alcoholic solution of components. The components are Belladonna, Sulphur, Apis mellifica, Conium, Phytolacca, Silicea and above nosode in the following proportions, wt %: Belladonna - 5, Sulphur - 20, Apis mellifica - 20, Conium - 10, Phytolacca - 10, Silicea - 5, nosode - 15, aqueous-alcoholic solution up to 100%. What is also declared is a method of treating bovine mastitis involving the intracisternal administration of the preparation. The preparation is administered in a dose of 5-10 ml per 1 animal once a day.EFFECT: declared group of inventions is highly effective in treating bovine mastitis.3 cl, 5 tbl, 1 ex
FIELD: veterinary medicine.SUBSTANCE: method comprises administering the preparation in a dose of 0.5 ml/25 kg live weight. The preparation is administered two times intramuscularly with an interval of 35 days. The first administration of the preparation is carried out 35 days before weaning, and the second - at the time of weaning the lambs. The preparation is used as a vitamin and mineral complex containing selenium taken in nanoscale state and zero valence of 0.125%, fat-soluble vitamin E 3.8%, water-soluble vitamin B1 0.1%, water-soluble vitamin B2 0.1%, water-soluble vitamin B5 0.1%, water-soluble vitamin B6 0.1%, water-soluble vitamin B12 0.1%, vitamin K3 - 0.1%, solubiliser Solutol HS 15 1.0-20.0%, and water.EFFECT: use of the method enables to reduce the negative effect of stress on animal body and to reduce the loss of live weight.7 dwg, 2 ex
FIELD: chemistry.SUBSTANCE: invention relates to encapsulation, particularly a method of producing microcapsules of a mixture of Vetom 1.1 and Sel-Plex in a carrageenan envelope. According to the disclosed method, Vetom 1.1 and Sel-Plex, taken in weight ratio of 60:40, are dissolved in dimethyl sulphoxide or dimethyl formamide. The obtained mixture is dispersed in carrageenan solution in benzene in the presence of an E472c preparation while mixing at 1000 rps. The mixture of the preparations and carrageenan are taken in weight ratio of 1:1 to 1:5. Butanol and distilled water, taken in ratio of 5:1 vol/vol, are then added. The obtained suspension of microcapsules is filtered out and dried. The process of producing the microcapsules is carried out at 25°C for 20 minutes.EFFECT: invention simplifies and speeds up the process of producing microcapsules, reduces losses during production thereof (high mass output).6 ex, 10 dwg
FIELD: medicine.SUBSTANCE: method for producing an agent for stimulating body cells involving preparing a mixture of aqueous solution of selenious acid and PEG 400; that is followed by preparing a mixture of hydrazine hydrochloride and PEG 400; the prepared mixtures are combined; the solution is put to dialyse against distilled water; surplus of water is driven off; the produced solution is added with hexamethylene tetramine; pH is reduced to 7.2-7.4; the method is implemented in certain circumstances.EFFECT: producing high-effective, ecologically safe agent by the synergism of colloidal selenium and hexamethylene tetramine on body cell stimulation.1 dwg, 2 tbl, 4 ex
FIELD: medicine.SUBSTANCE: method for producing an agent inhibitory the tumour cell growth, involving preparing a mixture of aqueous solution of selenious acid and PEG 400; that is followed by preparing a mixture of aqueous solution of hydrazine hydrochloride and PEG 400; the produced mixtures are combined; the solution is put to dialyse against distilled water; surplus of water is driven off in a rotary evaporator; the produced solution is added with silymarin dissolved in Solufor with dialysis against distilled water; pH is reduced to 7.2-7.4; the method is implemented in certain circumstances.EFFECT: agent produced by the given method possesses high inhibitory action on the tumour cell growth.4 dwg, 2 tbl, 2 ex
FIELD: medicine.SUBSTANCE: wound surface is treated with 3.0-1.5% hydrogen peroxide; then keeping the wound wet, Ichthyosin dressing prepared by streptocide powder 0.5-2.5g and Ichthyol ointment 5.0-10.0g dissolved in castor oil 94.5-87.5ml is applied. The agent is applied once a day; the therapeutic course makes 16 days. That is combined with performing an integrated treatment.EFFECT: invention provides both the antibacterial and anti-infectious, and local anti-inflammatory, local anaesthetic, wound-healing effects, improves the blood supply, stimulates the epidermis regeneration, intensifies the keratosis processes that enables accelerating the wound cleansing from the purulonecrosis process, and a length of preparation for aurografting.1 tbl, 2 ex
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to the pharmaceutical industry, particularly to a composition for treating or preventing the human immunodeficiency virus (HIV) or hepatitis C. The herbal composition used for treating or preventing the patients infected by the HIV or hepatitis C viruses and containing a herbal ingredient with tannin agents and catechin, and a pharmaceutically acceptable carrier; the herbal ingredient is Agrimonia Eupatoria (GAFT) and/or gambier (Uncaria gambir). A method for preparing the herbal composition for treating or preventing the patients infected by the HIV or hepatitis C viruses.EFFECT: composition is effective for treating or preventing the patients infected by the HIV or hepatitis C viruses.12 cl, 6 dwg, 2 tbl
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to veterinary science and aims at treating and preventing alimentary anaemia in young pigs. A preparation contains an iron dextran complex, nanosized and zero-valent selenium (Se0), vitamin E, vitamin B12 and water in the following proportions, wt %: iron dextran complex 0.0001-80.0, selenium (Se0) 0.0001-5.0, vitamin E 0.0001-20.0, vitamin B12 0.0001-10.0, water for injections - the rest.EFFECT: using the declared method provides compensating iron deficiency in young pigs, improving animal's growth and development, increasing total immunity and rapid adaptation to the varying ambient environment.4 tbl, 4 ex, 4 dwg
FIELD: veterinary medicine.SUBSTANCE: preparation for normalisation of lipid peroxidation processes in animals comprises, wt %: 2-ethyl-6-methyl-3-hydroxypyridine succinate 20.0-30.0, ascorbic acid 5.0-7.0, selenium (Se°) 0.3-0.5, polyvinylpyrrolidone 3.0-5.0, water for injection - the rest.EFFECT: antioxidant effect, prevention of excessive formation of lipid peroxidation products, high efficiency in normalisation of functioning of the system of antioxidant protection of animals and the process of lipid peroxidation, low toxicity and ease of administration.6 dwg, 5 ex
FIELD: biotechnology.SUBSTANCE: method of production of selenocystine consists in that 1 molar solution of sodium diselenide is prepared by adding 4.5 g of elemental selenium to 10 ml of 1 molar solution of sodium hydroxide (NaOH) in a three-necked flask. Then, 15 ml of distilled water is added and the solution is stirred using a magnetic stirrer. The separately prepared solution of natrium borane (NaBH4) by dissolving it in 25 ml of distilled water is added as drops to the three-necked flask with a suspension of elemental selenium to total decolorization of the solution, and another 4.5 g of elemental selenium are additionally added. 5 g β-chloro-l-alanine are dissolved in distilled water, and the solution is adjusted to pH 9 by adding 1M sodium hydroxide solution. Within 30 minutes the solution of β-chloro-l-alanine is added to the solution of sodium diselenide, located in the three-necked flask and stirred for 12-16 hours at a temperature of +37°C. Then, muriatic acid is added to the resulting solution dropwise to pH 2 and the air purging is carried out for 2-3 hours. The solution is filtered and adjusted with 10 M sodium hydroxide solution to pH 6-6.5. The solution is cooled to +5°C.EFFECT: increase in the yield ratio and improved purity.1 ex
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry and represents a skin care agent possessing the antifungal properties, containing propolis, ethanol, and a sulphur-containing component, differing the fact that the sulphur-containing component contains elemental nanodispersed sulphur with the components of the agent taken in certain amounts, wt %.EFFECT: invention provides extending the range of products possessing a wide spectrum of fungicidal action, and promotes the tissue regeneration processes.3 cl, 3 ex, 1 tbl
FIELD: medicine.SUBSTANCE: children referred to a follow-up group of frequently ill children are prescribed with Multitabs Junior 1 tablet once a day for 30 days within three therapeutic courses every second month and glucosaminyl muramyl dipeptide 1 tablet once a day sublingually for 10 days within three therapeutic courses every 2 months.EFFECT: method enables lowering a rate of respiratory infections in the frequently ill children by increasing the body resistance to infectious agents and filling the deficiency of vitamins and microelements.1 tbl, 2 ex
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to urology and balneotherapy, and can be used for treating patients with benign prostatic hyperplasia complicated by chronic prostatitis with a dominant symptom of nocturia. That is ensured by performing EHF therapy. The above is combined with an integrated resort treatment: oral administration of carbonate-hydrocarbonate-sulphate sodium-calcium low-mineralised (3.6-3.7 g/l) water in an amount of 280-300 ml three times a day 40-45 minutes before meals. The balneological treatment is prescribed: taking baths with similar mineral water at a temperature of 36-37°C with the exposure of each procedure 15 minutes in the number of 8 procedures every second day. Phytomicroenemas are prescribed in the number of 8 procedures every second day. That is combined with drug therapy with artesine 2 mg/day for 10 days.EFFECT: method enables the rehabilitation treatment which provides higher adaptation capabilities of the body, reducing the symptoms of the lower urinary tract with the dominant symptom of nocturia from 4-5 to 1-2 urinations a night and improving the quality of life in the patients undergoing the resort therapy It is manifested by the positive improvement of the patients' status as shown by the clinical examination, as well as by IPSS, Q max values.3 tbl, 3 ex
FIELD: medicine.SUBSTANCE: complex of biologically active preparations containing glutamic acid, glycine, cysteine, a pectin enterosorbent, a selenium polyvitamin-polymineral complex, a calcium preparation, as well as a cod liver oil preparation rich in nonesterified fatty acids omega 3 is administered. This complex is prescribed as a course of treatment once or twice a year for 4-6 weeks daily in the doses to provide the amounts of glycine of 300 mg, cysteine - 600 mg, glutamic acid - 4 g, selenium - 100 mcg, calcium - 4 g, cod liver oil - 25 ml with 12-15% nonesterified fatty acids omega 3, pectin - 4-5 g, as well as other microelements and vitamins in the doses to fill the normal physiological needs of the body.EFFECT: lower adverse effects of the general toxic and genotoxic action of nanosilver on the body by normalising lipid peroxidation and the morphofunctional state of the liver and spleen, a lower degree of the DNA fragmentation.3 tbl
FIELD: medicine.SUBSTANCE: invention relates to nutritive therapy and is intended for treatment and/or prevention of delayed recall function impairment in subjects who have 24-26 points by Mini-mental State Examination (MMSE). Claimed is application of composition for obtaining product for enteral introduction. Composition contains uridine or uridine phosphate, docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA), phospholipids, choline, vitamin E, vitamin C, selenium, vitamin B12, vitamin B6 and folic acid.EFFECT: claimed invention provides improvement of memory, in particular, delayed recall function, in patients with 24-26 points by MMSE.5 cl, 1 tbl, 2 ex
FIELD: medicine.SUBSTANCE: treating respiratory distress syndrome accompanying neonatal ventilation is ensured by measuring glutathione peroxidase (GSH-Px-3) with underlying drug therapy, and the measured value being less than 2.41 mcmole/l requires including intravenous bolus injections of the preparation Selenase in a therapeutic complex at 10 mcg/kg/day, once a day for 10 days.EFFECT: method provides increasing the survival rate in reducing a number of complications and a length of treatment by ensuring a lower severity of oxidative stress and a higher antioxidant protection of the body.1 tbl, 3 ex
FIELD: chemistry.SUBSTANCE: invention represents a pharmacological geroprotective composition, which includes a polyphenol component, vitamins and microelements, humic acids, containing polyphenol components, vitamin C, vitamin A, iron (II) chloride and selenium (IV) dioxide, with the composition components being in a specified ratio in wt %.EFFECT: increased life expectancy and retardation of tumour development.2 cl, 3 dwg, 2 tbl, 4 ex
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to a method of preventing complications of rhinitis or an influenza-like syndrome. The method of preventing complications of rhinitis or the influenza-like syndrome consists in the following: an isoosmotic ionic sea water-based solution with osmolarity, equal to 250-350 mOsm/kg, is introduced daily into each nostril of patients suffering from rhinitis or the influenza-like syndrome, and at the remission stage in the certain regimens.EFFECT: increased method efficiency.9 cl, 13 dwg, 13 tbl, 1 ex
FIELD: medicine.SUBSTANCE: there are used chymotrypsin 360-480 mg/day, trypsin 360-480 mg/day, papaine 900-1200 mg/day and 1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one (Inosine) 1200-1800 mg/day, zinc 7-10 mg/day, selenium 50-100 mcg/day, vitamin E - 30-400 mg/day, C - 180-500 mg/day, B-carotin - 4-10 mg/day taken orally for 2-3 weeks during a female's follicular phase.EFFECT: method enables reducing the binding of sperm-coating antibodies to sperm cells and improving the quantitative measures of the semen analysis through the complex immunomodulatory, proteolytic, inflammatory, antioxidant, antihypoxic and anabolic effects.1 ex, 1 tbl
FIELD: agriculture.SUBSTANCE: invention relates to biotechnology and can be used to increase the productivity of broiler chickens. The method comprises feeding the combined fodder with feed additive comprising selenium with the particle size of 20-60 nm, solubiliser Solutol HS 15 of vitamin E and water in a predetermined ratio, which is administered together with drinking water continuously during 15 to 42 days of broiler fattening at a dose of 0.125 wt.% of selenium and 3.8 wt.% of vitamin E per litre of drinking water. At that the feed additive is an aqueous solution of stabilised selenium particles with size of 20-60 nm, vitamin E and solubiliser Solutol HS 15.EFFECT: invention enables to normalise metabolic processes, the activate the body's antioxidant defence systems, to increase the feed conversion rate and to increase the live weight gain.2 tbl, 1 ex
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, namely a method of treating acne. The method of treating acne by prescribing line seed oil 10 ml 2 times a day, sodium selenite 90 mcg 1 time a day, tocopherol acetate 100 mg 2 times a day for 1 month.EFFECT: method of treating acne is effective and enables reducing the length of treatment.
FIELD: medicine.SUBSTANCE: claimed invention relates to application of effective quantity of selenate or its pharmaceutically acceptable salt in methods and compositions for treatment or prevention of neurological disorders, which are are not related to tauopathy. Neurological disorder, which is not related to tauopathy, is not a-synucleinopathy. Effective quantity of selenate or its pharmaceutically acceptable salt delivers over-dietary quantity of selenium. In some implementations invention relates to application of selenate or its pharmaceutically acceptable salt in combination with other means of therapy for application in methods of treatment or prevention of neurological disorders, which are not related to tauopathy.EFFECT: treatment or prevention of neurological disorders, which are not related to tauopathy.2 ex, 9 dwg
FIELD: medicine.SUBSTANCE: invention refers to veterinary science, and may be used for dog's hepatosis therapy. The method for dog's hepatosis therapy involves using a hepatoprotector, a microelement and herbal tea; the hepatoprotector is presented by the preparation Ursosan containing 250 mg of ursodeoxycholic acid; the microelement is selenium, and herbal tea is aqueous-alcoholic extract of camomile blossom clusters and birch buds used sequentially orally: Ursosan 10 mg per 1 kg of animal's body weight, selenium 3 mg per 1 kg of animal's body weight, aqueous-alcoholic extract of camomile blossom clusters and birch buds 1 ml per 1 kg of animal's body weight for 30 days every 12 hours.EFFECT: method enables conducting the effective therapy and prevention of dog's hepatosis ensured by increasing liver resistance to unfavourable effects and an ability to recover the injured hepatic tissue, as well as by avoided allergic reactions on the administered hepatoprotector.2 cl, 1 tbl
FIELD: medicine.SUBSTANCE: inventions relate to medicine, namely, to thoracic surgery, and can be applied for control of pneumostasis. For this purpose indicator substance is additionally introduced into breathing mixture in carrying out artificial lung ventilation (ALV). As such means sulfur hexafluoride in ratio 1:5000 is applied. Detection of indicator means and intensity of its leakage flow in real time mode is used to judge about presence and degree of microdefect in the area of sutured tissue.EFFECT: group of inventions makes it possible to realise effective control of lung tissue, bronchus stump and tracheobronchial sutures impermeability.2 cl, 2 ex
FIELD: medicine.SUBSTANCE: group of inventions refers to medicine, and aims at treating neurodegenerative disease. Selenate and a pharmaceutically acceptable salt thereof are applied in the methods and compositions.EFFECT: group of inventions enables reducing the onset of neurodegenerative diseases due to increased activity of PP2A protein phosphatase, reducing phosphorylation of tau protein and GSK3J3 activity inhibition.22 cl, 4 tbl, 17 dwg, 11 ex
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to chemical-pharmaceutical industry and veterinary science, and represents an immunomodulatory composition for animals which contains lactoferrin milk whey protein as active substance, and distilled water as a solvent. In addition to lactoferrin, the active substance contains lactalbumin and lactoglobulin milk whey proteins, wherein the active substance represents an aqueous solution of mixed milk whey proteins of the total protein concentration of 10 g/l, containing 10-20% of lactoferrin, 20-30% of lactalbumin, 60-70% of lactoglobulin; moreover, the active substance further comprises selenium nanoparticles in the following proportions, wt %: aqueous solution of mixed milk whey proteins of the total protein concentration of 10 g/l containing 10-20% of lactoferrin, 20-30% of lactalbumin, 60-70% of lactoglobulin, 0.1-100 selenium nanoparticles 00001-10, distilled water up to 100.EFFECT: invention provides a higher immunostimulating effects on the cell and humoral immunity.3 ex, 3 tbl
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to sports medicine, and may be used for the correction of the thyroid status and health of high-proficiency sportsmen, disturbed by intense cyclic physical activity; the method involves taking only two drugs "Selenium-active" in a dose of 1 tablet and "Ribose" in a dose of 0.25 g/kg of body weight in the period of intense physical activity. Daily, twice a day: before the first training session and before the second training session. The invention allows regulating the production of thyroid hormones by activation of the antioxidant system function and inhibition of the free radical processes.EFFECT: recovered health in sportsmen.2 ex
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry and represents a vitamin additive containing vitamin B1, vitamin B2, nicotinic acid, vitamin B6, biotin and pantothenic acid; and wherein the weight ratio of biotin to vitamin B1 makes 1:20 to 1:25; wherein the weight ratio of biotin to vitamin B2 makes 1:25 to 1:30; wherein the weight ratio of biotin to nicotinic acid makes 1:310 to 1:330; wherein the weight ratio of biotin to vitamin B6 makes 1:30 to 1:35; wherein the weight ratio of biotin to pantothenic acid makes 1:110 to 1:130.EFFECT: invention provides increasing activity, reducing the environmental stress effects, improving immunity of an individual, reducing the cases, the length and severity of respiratory infections.13 cl, 1 ex