(A61K31/734)

ethod for acute radiation esophagitis treatment // 2639463
FIELD: medicine.SUBSTANCE: for treatment of acute radiation esophagitis during radiation therapy, 25-30 g of "Koleteks gel DNA-l" is taken orally before a radiation therapy session. At that, during the radiotherapy session, placement of the "Kolegel-DNA-disk" material in the oral cavity is assigned with complete gradual dissolution. After completion of radiation therapy, inhalations with "Koleteks-Beta", hydrogel which is mixed with inhalation solution "Fluimucil" and water at a ratio of 3:5:2 accordingly are prescribed 2 times a day, 5-10 min. within 5-7 days. Inhalations are continued for the next 3-4 months, 5-7 days per month with a break of 20-25 days.EFFECT: invention reduces the frequency and severity of early and late radiation reactions in patients.3 ex
ethod for chronic generalised periodontitis treatment // 2628806
FIELD: medicine.SUBSTANCE: pins containing propolis, herbs and alginic acid, with the following components content, g per 1 pin: propolis 1; herbs 1; alginic acid 1, is injected into the periodontal pockets for 15 minutes during 5 days. Then, applications of gum plates containing propolis, collection of medicinal herbs and alginic acid with the following components content, g per plate: propolis 1.5; collection of herbs 1; alginic acid 1 are performed for 20 minutes. Chewable tablets containing beeswax, collection of medicinal herbs and alginic acid with the following components content, g per 1 tablet: beeswax 1.5; collection of herbs 1; alginic acid 1, are prescribed for taking in between meals.EFFECT: effective treatment of chronic generalized periodontitis with shortening of treatment terms.1 tbl, 2 ex
ethod for treatment of locally advanced breast cancer with tumour skin ulceration // 2626914
FIELD: medicine.SUBSTANCE: to treat locally advanced breast cancer with tumour skin ulceration, radiation therapy is performed in the mode of medium dose fractionation on the area of the mammary gland base and regional lymph drainage zone. In addition, prior to irradiation, a "Coletex-5-ftor" hydrogel tissue is applied to the tumour region for 5-7 days, 2-3 times daily. Prior to irradiation, a "Coletex-5-ftor" hydrogel tissue is applied to the area of skin tumour ulcers, where nitric acid silver is added as 0.2-2.0 wt %. At that, the marginal zones of skin tumour ulceration are treated with a hydrogel material on the basis of "Coletex-gel-DNA" sodium alginate, where betulin-containing birch bark extract is added as 0.1-1.5 wt %. After application of these hydrogels, a thermo-net is placed on top of them on the breast area, the net is cut out to overlap the ulcer area by 1.0-1.5 cm. Prior to radiotherapy, field markings in the ulcer area is carried out on the thermo-net.EFFECT: method ensures accelerated tumour ulcers healing, reduced drug load, reduced toxicity and a possibility of carrying out radiation therapy without interruption, reduced traumatization of tissues in the irradiation zone, and cessation of inflammatory processes.2 ex
Enterosorbent // 2612011
FIELD: medicine.SUBSTANCE: invention is an enterosorbent containing polysorb, apple pectin and sodium alginate in amounts of 50-60 wt %, 25-20 wt %, 25-20 wt %, respectively.EFFECT: agent has antioxidant, absorbent, detoxification, adaptogenic effect in the absence of side effects such as constipation, and improves the efficiency of treatment of skin allergic diseases.2 ex

Wound healing gel for external application // 2603459
FIELD: medicine.SUBSTANCE: invention refers to medicine and represents wound healing gel for external application, said gel contains sodium alginate, taurine, allantoin, glycerine, nipagin, and water in following proportions, wt %: sodium alginate 2.0-5.0, taurine - 4.0, allantoin - 0.5, glycerol - 6.5, nipagin - 0.1, purified water - up to 100.0.EFFECT: faster healing provides wound healing action, which occurs without formation of Keloids, and faster tissue regeneration.1 cl, 2 tbl, 1 dwg

ethod of the local immune correction in treating of the complicated mandibular fracture // 2599509
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to surgical dentistry, and can be used for local immune correction in treating of the complicated mandibular fracture at the patient. At that in the postoperative period apply a preparation betaleukin. In the course of treatment on a mucosa, locally, within the fracture line, "Coletex-beta" gel is daily applied under a protective dental bandage of Septopack to reduce risk of developing of traumatic osteomyelitis.EFFECT: invention provides anti-inflammatory effect in bone wound, accelerates the processes of osteogenesis.1 cl, 2 tbl, 2 ex
ethod for prevention and treatment of complications in radiation therapy of skin cancer // 2586043
FIELD: medicine.SUBSTANCE: invention can be used for prevention and treatment of complications during radiation therapy of skin cancer. That is ensured by patient's preparation for therapy by local skin treatment before and after each session radiation therapy. At that, local skin treatment is carried out by application of sodium hyaluronate with molecular weight of 30,000 Da and viscosity of 20-45 Pa·s-1 on the tumour area and 1-1.5 cm of intact tissues surrounding the tumour. From above, these skin areas are closed with a “Coletex-CA-Hem” drape and left for 4-5 hours before every session of radiation therapy. Drape is moistened by measure of drying. After the radiation therapy session, a moistened “Coletex-GKd-0.4” drape is applied on the same areas for 5-7 hours. Upon completion of the course of the radiation therapy, a moistened “Coletex-ADL” drape is daily applied on the exposure area during 1-2 weeks.EFFECT: method provides reduction of initial manifestations of radiation reactions on the skin, their later development at reduced degree of manifestation and duration of the clinical course, rapid relief of pain syndrome.1 cl, 3 ex
ethod for laparoscopic cholecystectomy in patients receiving treatment by peritoneal dialysis // 2582456
FIELD: medicine.SUBSTANCE: patient receiving treatment peritoneal dialysis, performing laparoscopic cholecystectomy. In each of trocar wounds cooled hydrogel material “Coletex-ADL” is introduced in amount of 1-2 ml. After extraction of cystic arteries and duct peritoneal catheter is removed from pelvic and placed in subhepatic space. After cholecystectomy through catheter space is filled in with “Coletex-AKL” in amount of 75-150 ml. After removing trocars in operational wounds cooled “Coletex-ADL” is introduced again in amount of 1-2 ml. Wounds are closed. After 12-36 hours from surgery repeated introduction of “Coletex-ADL” in amount of 20-30 ml is conducted through peritoneal catheter. Catheter reduced into small pelvis using metal stilette.EFFECT: method reduces risk of intra-operative and infectious complications of laparoscopic cholecystectomy in patients receiving treatment by peritoneal dialysis, allows to reduce period of peritoneal dialysis resumption.1 cl, 2 ex
ethod of treating constipation syndrome in children // 2582227
FIELD: medicine.SUBSTANCE: invention is intended for treating constipations in children. Complex therapy with prescribing of preparation “Motilak” is conducted. “Motilak” is received in 14 hours in a dose of 5-10 mg/day, nonabsorbable antacid “Maalox” in dosage of 2.5-5 ml 3 times a day 10-15 minutes after meals, “Natalcid” suppositories alternated with suppositories with sea buckthorn oil and administered at bedtime through rectum, for period of treatment is prescribed milk-free diet, treatment is carried out for 8 weeks.EFFECT: method allows to improve colon motility that provides higher clinical effectiveness, accelerates therapeutic effect, prolongs remission, normalises emptying of intestine.1 cl, 2 ex

Therapeutic nutrient composition // 2571815
FIELD: medicine.SUBSTANCE: therapeutic nutrient composition containing a mix of dihydroquercetin, sodium alginate and ascorbic acid taken in certain mixture ratio.EFFECT: composition possesses the improved antidiabetic, hypoglycaemic, hypolipidemic, antihypertensive, antiadipogenic, anti-inflammatory and antioxidant properties.3 cl, 10 dwg, 7 ex

ethod of treating periodontitis with using kanalgat gel // 2567464
FIELD: medicine.SUBSTANCE: one stage involves administering anti-inflammatory gel into gingival pockets and conducting laser-phoresis within an area of the preparation administration. The above gel is Kanalgat dissolved in distilled water in ratio 3:1. The gel is additionally applied over a gingival margin with covering a dental surface. The laser-phoresis has the following parameters: transmission power 0.4 Wt, energy density 18-20 J/cm2, and wave length 662 nm. The exposure is performed through a gingival margin and covers upper and lower jaws in segments: 1.8-1.3; 1.3-2.3; 2.3-2.8 for the upper jaw segments and 3.8-3.3; 3.3-4.3; 4.3-4.8 for the lower jaw segments. The exposure length makes 4 minutes per each segment: 2 minutes from a vestibular side and 2 minutes from a palatal (tongue) side. After the gel is removed, a dressing of Solcoseryl dental adhesive paste is applied. The therapeutic course makes 6 daily procedures.EFFECT: reducing the length of treatment and achieving stable remission ensured by the presented integrated exposure and pharmacological properties of the used preparations.1 tbl, 2 ex
ethod of obtaining therapeutic hydrogel // 2563232
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to the medical and pharmaceutical industry. Described method which includes the introduction of a medication into a polymer composition of a group of polysaccharides, gamma-sterilisation 6-15 kGr and introduction of sorbic acid or its water-soluble salts, or benzoic acid or its water-soluble salts, or a mixture of the said acids in a concentration of 0.05-1.00 wt % with constant mixing until a homogeneous consistency is obtained. As the polymer composition a mixture of sodium alginate and hyaluronic acid or sodium hyaluronate with the component ratio of 5:1, or a mixture of sodium alginate and pectin with the component ratio of 6:1, or swollen sodium alginate is used. It is suggested that the concentration of the medication should be selected from 0.25 to 20 wt %.EFFECT: method eliminates the growth of micriflora in the therapeutic hydrogel, making it possible to avoid large economical loss, allows delaying γ-sterilisation and does not allow the drop of the therapeutic hydrogel viscosity in the process of γ-sterilisation, provides the required period of medication prolongation.26 cl, 23 ex
ethod of treating radiation and interstitial cystitis // 2557949
FIELD: medicine.SUBSTANCE: method involves instilling the Colegel ADL gel preparation every second day from the 1st to 20th day, and then Colegel DNK L two times a week from the 21st to 56th day.EFFECT: invention enables relieving pain symptomatic, reducing the rate and length of recurrences in the patients.3 ex

ethod of bone tissue substitution // 2553368
FIELD: medicine.SUBSTANCE: described is a method of bone tissue substitution, in which as a bone-substituting material applied is a biodegradable material of the following composition, wt %: biological hydroxyapatite - 50-52, magnesium phosphate - 30-32, calcium hydrophosphate - 8-10, calcium hydroxide - 4.8-5.3, sodium alginate - the remaining part. As a binding agent applied is casein in the form of an ammonia solution with the ratio of powder mass of the biodegradable material to the ammonia casein solution of 1:1-1.5.EFFECT: reduction of terms and improvement of surgical operation results.4 dwg, 2 tbl, 2 ex

Product, containing glucomannan, xanthan gum and alginate for treatment of metabolic disorders // 2553348
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry and represents clinical nutrition for prevention, treatment or relief of one or several symptoms, associated with impairment of metabolism or its disorder, which contains composition of polysaccharide high-viscosity dietary fibre, including viscous fibre mixture or its complex, consisting of from 48% to 90% in wt % of glucomannan, from 5 to 20 % in wt % of xanthan gum and from 5% to 30% in wt % of alginate, as well as, at least, one macroelement, selected from the group, consisting of protein carbohydrate and fat, where clinical nutrition is composed in order to provide dose of composition of polysaccharide high-viscosity dietary fibre from 20 g/day to 35 g/day for time period, effective for prevention, treatment and relief of one or several symptoms, associated with impairment of metabolism or its disorder.EFFECT: invention ensures extension of arsenal of means, preventing, relieving or treating one or several symptoms, associated with impairment of metabolism or metabolic disease.14 cl, 6 ex, 20 tbl, 48 dwg

ethod of treating mastoid diseases complicated with thrombophlebitis // 2544370
FIELD: medicine.SUBSTANCE: treating mastoid diseases complicated with thrombophlebitis involves removing a pathologically changed bone, opening all mastoid process cells, exposing a sigmoid sinus and puncturing it with removing a thrombus. That is followed by plugging a sinus lumen with High-structure sodium alginate hydrogel matrix with pre-added dioxidine 0.03 g. The matrix surface is coated with Hydrogel Coletex AKL tissue. The antretomastoid cavity walls are covered with the same material, whereas a latex tampon pre-coated with Hydrogel Coletex-ADL tissue is used for plugging.EFFECT: method provides the early generation of granulation tissue, the protective and haemostatic effect in the wound, reduces the length of treatment, prevents early and late complications and thereby improving the patient's quality of life.3 dwg, 2 ex
ethod for kidney allotransplantation // 2544362
FIELD: medicine.SUBSTANCE: donor's kidney is grafted. After an uretherocystoanastomosis is formed, trocars are inserted within renal poles. Their outer ends are embedded into subcutaneous fat. Coletex AKL Hydrogel tissue 150-1,500 ml is placed into a retroperitoneal space. The wound is closed in layers. The retroperitoneal space is filled with Coletex ADL Hydrogel 100-800 ml through the trocars 8-16 hours after the surgery. The re-filling procedure is performed every 24-48 hours for 6-8 days. The trocars are removed.EFFECT: method reduces the risk of acute and chronic allograft nephropathy, prevents the haemodynamic disorders of the donor organ.
ethod of treating locally advanced oropharyngeal cancer // 2539418
FIELD: medicine.SUBSTANCE: treating locally advanced oropharyngeal cancer is ensured by a radiation therapy in the mode of dynamic dose fractionation. The radiation therapy is started by supplying a fraction dose of 2.4 Gy. After 2 days of treatment gap, the patient is exposed to total fractions at a fraction dose of 3.6Gy for three days. Each session is precede by placing high-structure hydrogel matrix of sodium alginate under a patient's tongue with metronidazole 150mg and bilberry 20-35mg pre-introduced into the matrix, for 4-5 hours twice every 1-2 hours. The two following sessions of the exposure at a fraction dose of 2.4 Gy are preceded by placing the matrix once under the tongue for 4-5 hours. After 2 days of treatment gap, the following 5 sessions of the radiation therapy are performed at a fraction dose of 2.4 Gy to a cumulative dose of 30Gy. Colegel-DNA-Ch high-structure disk is preliminary placed under the tongue for 4-5 hours.EFFECT: method enables avoiding the compulsory gaps of the radiation therapy by reducing a rate of severe local radiation reactions, and provides the target delivery and accurate dosage of metronidazole administered into the patient's body leading to the partial death of well-oxygenated cells and re-oxygenation of hypoxic tumour cells.2 ex
ethod for producing therapeutic tissue // 2539381
FIELD: medicine.SUBSTANCE: invention refers to medicine. What is described is a method for producing a therapeutic tissue involving producing a polymer base containing alginic acid salt, administering an active substance in a therapeutically effective amount, agitating the mixture in a slow-speed mixer, applying the prepared composition on a textile material containing at least 50% cellulose fibres, while the composition of the polymer with the active substance is applied on the textile material through a mesh template at a cell size of 200 to 450 mcm to generate a continuous polymer layer on the face surface of the textile material not penetrating to the inner side.EFFECT: method enables extending the range of therapeutic agents and biologically active additives, enabling variation of their concentration that causes their concentration in treating various diseases, enables fast transformation of the technological process and its cost-effectiveness.28 cl, 23 ex

ethod for surgical treatment of frontal sinusites // 2539372
FIELD: medicine.SUBSTANCE: frontal sinus is approached in a typical location and sanitated. After the sanitation procedure, a bone defect is covered with high-structure hydrogel matrix of sodium alginate, wherein dioxidin 0.03g and ε-aminocapronic acid 0.15g are pre-administered. The sinus is obliterated with MK-9M osteoplastic composition. The approach point is covered with the same matrix, on the top of which the wound is closed completely and coated with Coletex-ADL hydrogel tissue.EFFECT: method provides preventing early and late suppurative complications, promotes preventing intracranial complications, reduces the recovery time by the protective antiseptic, homeostatic, antitoxic properties of the used matrix, which prevents the composition prolapse into the intracranial cavity as a brace.4 dwg, 2 ex
ethod of treating cystitis // 2537031
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to methods of treating cystitis of various origins. Increasing the clinical effectiveness and reducing a probability of recurrences are ensured by administering therapeutically active and gel preparations possessing a high adhesion to urothelium walls. The method involves instilling sodium alginate in the form of Colegel gel containing the therapeutically active preparations dioxidine, lidocaine, deoxyribonucleate, sodium hyaluronate in a therapeutically effective amount with the instillation procedure suggested to be performed according to the schedule specified depending on the cystitis origin. If observing chronic bacterial recurrent cystitis, the following schedule is presented: instillations of Colegel-ADL from the 1st to 10th therapeutic day daily, instillations of Colegel-DNK-L from the 11th to 20th therapeutic day every second day, 2-month instillation of Colegel-Hyal once a week. Treating radiation and interstitial cystitis requires the following therapeutic schedule: instillations of Colegel-ADL from the 1st to 20th day, while Colegel-DNK-L and Colegel-Hyal are instilled once twice a week from the 21st to 56th day alternated every second day. The presented therapeutic schedules using the given therapeutically active preparations enabling relieving pain, reducing a rate and a length of recurrent cystitis.EFFECT: using these therapeutic schedules is high-efficient and safe.1 ex
ethod of treating perforations and disruption of lower one-third of oesophagus // 2536830
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to thoracic surgery, and can be used to close defects of the lower one-third of the oesophagus. A laparotomy and a sagittal diaphragmotomy are performed. The oesophageal wall defect is closed with a single-layer uninterrupted absorbable mass suture. The suture is started from the proximal end of the defect with the first knot tightened into the oesophageal lumen. A fundoplication cuff is created with covering the suture with the stomach. One of the gastric walls is fixed by interrupted sutures surrounding the closed oesophageal defect to form a cavity between the closed oesophageal defect and the gastric wall. The cavity is filled with Coletex ADL hydrogel tissue. The fundoplication cuff is fixed by interrupted sutures circularly to the diaphragm. The pleural spaces, mediastinal and subphrenic space are drained.EFFECT: method provides reducing the time of recovery, reducing a probability of postoperative complications and faster rehabilitation by forming the reliable sutures, long bactericidal effect on the suture area, dividing the pleural space and abdominal cavity.1 ex
ethod of treating bronchoesophageal fistulas // 2536828
FIELD: medicine.SUBSTANCE: method involves the endoscopically controlled introduction of Coletex-D gel into a fistulous passage from the oesophagus until filled completely. The following exposure to a laser light at wavelength 0.66 mcm, output power 15-45 mWt/cm2 covers a fistulous passage mouth for 5-7 minutes to be repeated in the same mode every second day. The course of the laser light exposure makes 8-10 procedures.EFFECT: method provides the adequate therapy requiring no abdominal surgeries and the lower risk of chest and abdominal injuries, the shorter rehabilitation period by improved sealing of the fistulous passage, fistula healing, reduced inflammatory process.2 ex
ethod for preparing sterile self-gelling alginate system // 2535035
FIELD: medicine.SUBSTANCE: method for preparing involves forming a dispersion of water-soluble sodium alginate and particles with gelling calcium ions; water-soluble sodium alginate is introduced into calcium carbonate directly in the concentration of 0.08-0.12 wt %, and adding organic acid specified in 2,4-hexanediene, para-toluic, 4-propyloxybenzoic in an amount of 0.12-0.36 wt % with the ratio of calcium salt and the above acids of 2:3, 1:2, 1:3 respectively. The prepared alginate system is settled to form a gel matrix at room temperature that is followed by γ-sterilisation.EFFECT: hydrogel matrixes hold the shape stability after the γ-sterilisation procedure, possess the excellent tactile properties being soft and elastic, provide the targeted prolonged drug delivery.6 ex

Compositions for treatment of gastroesophageal reflux disease (gerd) // 2524639
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to the pharmaceutical industry, in particular to a peroral pharmaceutical composition, which contains polysaccharides from platyclades of Opuntia Ficus Indica, an extract of Olea Europeae leaves, alginate and sodium bicarbonate in a specified ratio. Components of the composition described above act with respect to reduction of gastroesophageal reflux.EFFECT: peroral pharmaceutical composition is intended for the prevention and treatment of gastroesophageal reflux and GERD.4 cl, 9 tbl, 6 dwg

Composition for preparing dosage form having prolonged action // 2519723
FIELD: medicine.SUBSTANCE: what is described is a composition for preparing a dosage form having prolonged action and containing drug preparations with radioprotective activity: Mexidol, Dimexidum, urea, methyluracil, sodium deoxyribonucleate, as well as a water-soluble polymer or a mixture of polymers specified in a group: sodium alginate, pectin, chitosan salt, water, and a substance or a mixture of substances having antiradical properties, and specified in a group consisting of sea buckthorn, bilberry, glycerol, polyethylene glycol, with the following ratio of ingredients, wt %: thickening polymer 1.0-8.0; pharmacological agent in a therapeutically effective amount; substances having antiradical properties 0.5-6.0; distilled water - the rest.EFFECT: higher degree of intact tissue protection against radiation damages.8 ex, 2 tbl
Composition for treating cystitis // 2519010
FIELD: chemistry, pharmacology.SUBSTANCE: composition contains 0.8-2.0 wt % of sodium hyaluronate, 1-3 wt % of sodium alginate and distilled water to 100 wt %. Composition possesses prolonged adhesion to glycosamine-glycan urothelium layer and creates barrier for adhesion of bacteria to affected tissues by covering urothelium with biopolymer film.EFFECT: composition ensures expressed therapeutic effect, considerably reduces edema of urinary bladder walls, stops or considerably reduces pain syndrome, considerably reduces number of cystitis recurrences.3 ex
ethods of treating patients with locally advanced uterine cancer // 2514342
FIELD: medicine.SUBSTANCE: there are performed beam therapy, intracavitary therapy and chemotherapy. For 5-7 days before the beginning of the radiation, Colagel-Beta with 1 β-interleukin 20 ml is introduced into a vaginal tube daily. Each session of the intracavitary therapy is preceded by introducing Colegel with 5-fluoruracil 20-25 ml into an uterine cavity and exposed for 30-40 minutes. Besides, from the beginning of the beam therapy 40-50 minutes after the radiation session, sodium alginate gel 20 ml containing methyluracil, dimethyl sulphoxide and hydrocortisone are introduced into a rectum and a bladder in a therapeutically effective amount. 5-10 procedures are performed.EFFECT: providing faster regression of the tumour, reducing the rate and severity of radiation injuries of the rectus and bladder adjacent with the uterus with no risk of severe systemic toxic manifestations, including in senior patients with comorbid inoperable diseases and extended tumours.3 ex
ethod for preparing therapeutic hydrogel // 2508091
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine, namely to a method for preparing a therapeutic hydrogel material involving mixing an aqueous solution of sodium alginate and a drug preparation, dispersing a cross-linking agent that is presented by calcium sulphate in glycerol in the concentration of 0.8-2.5%, mixing the dispersion with the prepared mixture of sodium alginate with the drug preparation in ratio 1-2:4-6, placing the prepared product into a tiling pattern and keeping it till form-stable, conducting gamma sterilisation; the formation process involves the mechanical stability measurements with the diametral compression of the formed hydrogel; the hydrogel is considered to be formed once a thickness of the formed hydrogel varies with the diametral compression by 10-30%.EFFECT: invention provides the wider medical variation of the drug concentrations, preparing high-thixotropy soft hydrogel materials (tablets) easy to administer, including through rectum, preparing the materials that preserve its all their physical-technical and mechanical properties after the gamma sterilisation along with the sterility.4 cl, 10 ex
ethod of body exposure // 2502528
FIELD: medicine.SUBSTANCE: invention refers to medicine, more specifically to physiotherapy, otorhinolaryngology, audiology, rehabilitation medicine, and may be used for the physiotherapeutic body exposure in the diseases developed in cerebral and cervical human tissues and organs, such as perceptive hearing loss, siagonantritis, eustachitis, temporomandibular dysfunctional pain syndrome, odontogenous or rhinogenous trifacial neuralgia, Bell's palsy etc. For this purpose, a concha of auricle is exposed to electric current by introducing an electrode into an ear to contact a cavity and cup of concha tightly. Besides, the above are exposed to electric current through an electrode placed into a nasal passage. The electrodes are wrapped in a wet tissue made of a non-woven material with surface density 160-180 g/m2 containing a polymer layer of sodium alginate containing a drug preparation or a mixture thereof. The exposure is generated by direct electric current with its intensity to be gradually increased from 1 to 5 mA. The procedures are sequential at first from one side, and then from the other side. The exposure time makes 10-15 minutes from each side. The therapeutic course is 8-12 daily procedures.EFFECT: appropriate prescription of the drug preparations enables the method providing the evident analgesic and anti-inflammatory action, activation of the tissue immune processes, improved innervation within the exposure region, recovered locomotor function of the temporomandibular joint and masticatory muscles, higher contractive activity of the muscles of expression, reduced development of any negative responses and complications ensured by the combined action of direct electric current and prolonged action of the pharmacological preparations in the presented tissues.3 ex
ethod of treating rectal cancer // 2477641
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly oncology and surgery, and may be used in treating rectal cancer. That is ensured by teleirradiation, oral administration of capecitabine, intrarectal administration of metronidazole, local SHF hyperthermia followed by a surgical intervention. Capecitabine is administered 2000 mg/m2 from the 1st to 14th days. Metronidazole 10 g/m2 is intrarectally administered on the 3rd and 5th therapeutic days as a part of a composite mixture having the following proportions, wt %: metronidazole 12-22, sodium alginate 4-6, dimethylsulphoxide 2, distilled water up to 100. The 5-hour exposure of metronidazole is followed by a session of teletherapy. The local SHF hyperthermia at temperature 41-45° for one hour follows a session of teletherapy on 3rd, 4th and 5th therapeutic days. The surgical intervention is conducted 4 weeks after the completion of the preoperative therapy.EFFECT: method provides ensuring complete therapeutic pathomorphism of the tumour in 25% of patients, reducing toxic and post-therapeutic complications, as well as enables conducting sphincter-preserving surgical interventions.3 ex

Compositions of biocompatible microparticles of alginic acid for regulated release of active ingredients in intravenous introduction // 2476235
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions refers to medicine, particularly to the compositions of biocompatible microparticles of alginic acid for regulated release of the active ingredients in intravenous introduction, to a method for preparing and using it. The composition contains microparticles of alginic acid of 5 mcm or less with negative Z-potential; the active ingredient represents blood coagulation factor.EFFECT: group of inventions provides a combination of size adequate for prolongation of blood half-life or survival of the active ingredient, with lower hepatic absorption and fast cell clearance in intravenous introduction.23 cl, 5 ex, 8 tbl, 3 dwg
ethod of treating patients with gastroesophageal reflux disease // 2472542
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely gastroenterology, and may be used for treating the patients with gastroesophageal reflux disease. That is ensured by the simultaneous complex introduction of drug preparations, namely a proton pump inhibitor, a prokinetic, an antacid and the intravenous blood laser exposure. The proton pump inhibitor is presented by Ultop 20 mg 2 times a day. The prokinetic is presented by Ganaton 250 mg 3 times a day. The antacid is Gaviscon 10 ml 3 times a day. The intravenous blood laser exposure is performed at wave length 0.405 mcm at output power in a disposable light guide end 1-1.5 mWt at pulse frequency 80 Hz in an continuous emission mode for 15 minutes. The 5-6 daily procedures of the intravenous blood laser exposure are required for mild gastroesophageal reflux disease, the prostaglandin E2 level equal to 1025±112 pg/ml and more, the catalase level equal to 380±21 mcat/l and more, the ceruloplasmin level equal to 3.9±0.7 mcmole/l and more, the malonic dialdehyde level 12.6±1.5 mcmole/l and less. The 9-10 daily procedures of the intravenous blood laser exposure are required for medium and severe gastroesophageal reflux disease, the prostaglandin E2 level equal to 1025±112 pg/ml and more, the catalase level equal to 380±21 mcat/l and more, the ceruloplasmin level equal to 3.9±0.7 mcmole/l and more, the malonic dialdehyde level 12.6±1.5 mcmole/l and less.EFFECT: method provides higher clinical effectiveness of the drug-induced therapy, earlier reduction of the symptoms, reduced length of treatment and rate of aggravations, lower drug load on the patient's body ensured by normalised lipid peroxidation, higher level of anti-inflammatory prostaglandins, normalised microcirculatory system, balanced vegetative nervous system.2 tbl, 2 ex
ethod of treating breast cancer // 2471520
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to oncology, and may be applied in treating breast cancer. Breast is resected. Coletex-Mex textile tissue is applied for 4-7 days in 7-10 postoperative days on the postoperative scar and remained breast tissues, and changed 2 times a day. For the following 4-7 days, Coletex-D hydrogel tissue is applied and coated with Coletex-SMT textile tissue in the same regiment. The applications for 8-10 hours a day are combined with radiation teletherapy to SRD 20 Gy - 25 Gy. The radiation teletherapy is combined with the applications of Coletex gel DNA hydrogel coated with Coletex-Mex textile tissues from above changed twice a day. The radiation teletherapy is followed by the application of Coletex-SMT tissue and Coletex-Mex tissues changed every 12 hours to complete rehabilitation.EFFECT: method provides fast healing of the postoperative wound, reduced length of the beginning of radiation and chemotherapy, minimal rate of complications and side reactions thereby improving patient's quality of life.1 ex
ethod of treating cervical cancer // 2454256
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely oncology, and can be used for treating cervical cancer. That is ensured by radiation teletherapy and brachytherapy. Each brachytherapy session is preceded by bringing the Hydrogel Coletex-M Tissue 3-5 ml to the tumour before 12-18 hours. Before gel contact, the Coletex-M Tissue is introduced. Further,1-1,5 hours prior to the brachytherapy session, the textile tissue is removed, and Hydrogel Coletex-ADL Tissue 4-6 ml is brought to the tumour. Preliminary, the Hydrogel Coletex-ADL Tissue is added with lidocaine to achieve the gel concentration 4-6%.EFFECT: method provides reduced total toxicity and drug load ensured by the required concentration of metronidazole maintained in the tumour before the radiation session, and also analgesia without using narcotic preparations, optimised time and geometry of centring introduction that allows intensifying the damage exposure on the tumour.2 ex
ethod of treating locally advanced breast cancer with tumour skin ulceration // 2447913
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to oncology, and may be applied in treating locally advanced breast cancer with tumour skin ulceration. That is ensured by CMF chemotherapy, 5-fluorouracil chemotherapy in the form of Koletex-5-fluor tissue applications and radiation therapy. The Koletex-5-fluor tissues are applied on the ulcer centre daily 2-3 times a day and changed every 2 days. The radiation therapy is performed in a mode of average dose fractionation on an area of a breast base and an area of regional lymph outflow. Herewith, 5-7 days before the radiation therapy, the ulcer area and the whole breast are coated with a thin layer of the 'Hydrogel Coletex-Phyto Tissue' material 3 times a day. Additionally, the ulcer area is coated with the 'Coletex-Phyto' textile tissues above the hydrogel material. The radiation directly covers the tissue and hydrogel. The ulcer borders are treated with the 'Hydrogel Coletex-Phyto Tissue' material 2-3 times a day for the whole period of radiation. After the termination of the radiation therapy, the ulcer centre is coated with the 'Coletex-Phyto' textile tissues, while the ulcer borders are treated with the 'Hydrogel Coletex-Phyto Tissue' material for 1-2 weeks.EFFECT: implementing the method provides higher clinical effectiveness ensured by faster healing of tumour ulcers, reduced drug load, lower toxicity and enabled continuous radiation therapy.1 ex
Oral pharmaceutical composition for treating inflammatory gastrointestinal diseases // 2445965
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine and concerns an oral pharmaceutical composition for treating inflammatory gastrointestinal diseases containing sodium alginate, a functional additive and water. As a functional additive, the composition contains dipeptide glutamyl-tryptophane.EFFECT: invention provides higher efficacy of the composition in treating inflammatory gastrointestinal diseases.1 cl, 6 ex, 11 tbl

ethod for preparing antiviral agents (versions) // 2443410
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine, particularly pharmaceutical industry. The method is characterised by the fact that: - viscosity of 1% sodium alginate in water makes 9-26 mPa·s, and concentration of calcium in colour sugar solution is 0 mg/l to 120 mg/l. - viscosity of 1% sodium alginate in water makes 26-90 mPa·s, and concentration of calcium in colour sugar solution is 0 mg/l to 80 mg/l. - viscosity of 1% sodium alginate in water makes 90-250 mPa·s, and concentration of calcium in colour sugar solution is 0 mg/l to 60 mg/l.EFFECT: improved antiviral agent technologies (versions) with using a complex of remantadin and sodium alginate.3 cl, 2 tbl
Compositions of particles containing alginate or alginic acid // 2441648
FIELD: chemistry.SUBSTANCE: invention is referred to the area of pharmacy, namely to the particle compositions for swallowing containing: a. alginate and/or alginic acid; b. bicarbonate and/or carbonate; c. carboxylic acid; and d. agglomerating agent that is a compound such as low-molecular polyol that gives to the particles composition the ability to still flow but not to release significant amount of small particles in the air. The compositions are suitable for direct oral intake by patient and can be used to relieve the esophagus and stomach state.EFFECT: said compositions of particles have excellent flow properties, ability to suppress the dust formation, organoleptic capabilities and stability.21 cl, 6 ex
ethod of treating chronic inflammatory bowel diseases // 2431489
FIELD: medicine.SUBSTANCE: invention refers to medicine, and aims at treating chronic bowel diseases. In the morning, ozone therapy is applied. Overnight, hydrogel containing sodium alginate with Dimexidum in the concentration 6-9 % is introduced through rectum. The medicinal agent is introduced in amount 50-100 ml, with exposition of 4-6 hours. Therapy course is 5-7 daily sessions.EFFECT: method allows relieving inflammatory process and reducing length of treatment.3 ex
Composition for colonic diseases // 2421212
FIELD: medicine, pharmaceutics.SUBSTANCE: composition for colonic diseases containing a polymeric base in the form of sodium alginate and Dimexidum in the amount 6-9% is offered. The invention can be used for treatment of the terminal colonic diseases, namely hemorrhoids, rectal inflammation, proctosigmoiditis, rectal fissures, and also for prevention and treatment of radiation complications in rectal and urogenital cancers.EFFECT: evident therapeutic effect of Dimexidum in synergetic action of the ingredients of the composition with no side complications after a prolonged 4-8-hour contact of an affected region of mucosa with the preparation is shown.2 ex
ethod of treating rectal cancer // 2398608
FIELD: medicine.SUBSTANCE: invention refers to medicine, oncology, and can be used for treating rectal cancer. That is ensured by daily 5-fluorouracil chemotherapy for 5 days combined with the following introduction of a platinum preparation. It is followed with gamma therapy according to the dynamic dose fractionation with the amplified fractions of 4 Gy for the first 3 days. Further, said ray therapy is ensured by small fractions in the superfractionation mode, twice a day, every 4-5 hours, of 1.25 Gy to total basic dose of 47.0 Gy. In addition, every night at bedtime, Derinat gel is introduced in microenemas of 5-10 ml for the first 5 days of treatment, of 10-20 ml in amplified fraction radiation, of 30-35 ml in small fraction radiation, of 25-30 ml after the termination of the radiation course for 2 weeks.EFFECT: method provides increasing TBD to 47,0 Gy that is an equivalent of 50 Gy of conventional radiation dose fractionation, as normal tissues allow delivering the specified dose without the evident ray-induced reactions.2 ex
ethod of treatment of locally extended rectal cancer // 2392019
FIELD: medicine.SUBSTANCE: invention refers to medicine, oncology, and can be used for treatment of locally extended rectal cancer. For this purpose in preoperative period the tumor is affected with distance-type gamma-irradiation with single focal dose of 5 Gy, at dose ionization maximum of 100 cGy/min. The course of radiation treatment is 5 days. Thus in 1st, 3d and 5th days of radiation treatment 3-4 hours prior to irradiation a composite mixture of: (wt %) sodium alginate 46; 5-fluorouracil - 0.5; distilled water up to 100 ml is intrarectally administered.EFFECT: method enables to improve immediate and long-term results of treatment, to reduce possibility and severity of early and late radiation reactions of organs and tissues within the irradiation field, to reduce total and hematologic toxicity.1 ex

Therapy of rectal cancer // 2367489
FIELD: medicine.SUBSTANCE: therapy of rectal cancer is ensured by preoperative beam therapy "РОД" 5 Gy during 5 days, in combination with local microwave hyperthermia at temperature 42.5-43°C during 60 minutes for 3, 4 and 5 days after beam therapy sessions. A composite mixture containing sodium alginate, 2% dimethyl sulfoxide and 5-fluorouracil is introduced through rectum at exposition 6 hours in 1, 2 and 4 days prior to beam therapy sessions. For 3 and 5 days, at the same exposition, said composite mixture containing metronidazole instead of 5-fluorouracil is introduced. Further, surgical procedure follows.EFFECT: due to selected introduction regiment of chemotherapeutical preparations as parts of the composite mixture, the method provides high concentration thereof in rectal tumours without side effect, ensures high degree of beam pathomorphism in vast majority of the patients of said category, the absence of recurrent tumour and dissemination within 3 postoperative years.2 ex

Agent inducing maturing of dendritic cells // 2361598
FIELD: medicine.SUBSTANCE: invention concerns medicine, be more specific to oncology, and concerns the substances stimulating maturing of dendritic cells (DC). Application of fucoidan from Fucus evanescens or polysaccharide composition from Fucus evanescens consisting of fucoidan in amount of 60-80% and poly-mannuronic acid in amount of 20-40%, as an agent possessing ability to induce maturing of dendritic cells is offered. The declared fucoidan preparations have a standardised composition and, hence, possess direct biological effect. They keep the properties for long time (3 years).EFFECT: increase of DC functional activity under the influence of the declared substances.8 dwg
ethod for treatment of inflammatory diseases of tunica mucosa of mouth of prosthetic etiology // 2354389
FIELD: medicine.SUBSTANCE: invention is related to medicine, namely, to orthopaedic stomatology and may be used in treatment of inflammatory diseases of mouth tunica mucosa in area of dentures and/or implants. For this purpose affected section of tunica mucosa is coated with argacol of 0.3-0.6 mm layer. Treatment is carried out 2-3 times per day for 5-14 days.EFFECT: application of argacol in specified mode makes it possible to provide for high treatment effect with no unpleasant feelings of patient.2 cl, 2 ex

Powder-like antacide pharmaceutical composition, pharmaceutical preparation containing it and method of obtaining it // 2351332
FIELD: medicine.SUBSTANCE: antacid composition contains sodium alginate, antacid soluble agent or combination of antacids, proton pump inhibitor, diluent and sweeteners. Up to 30% of sodium alginate, present in composition together with total amount of proton pump inhibitor, are homogenously distributed throughout the surface of soluble antacid agent or combination of antacids of composition, remaining amount of sodium alginate, present in composition, has humidity less than 2%. Composition ensures stability of proton pump inhibitor.EFFECT: composition performs quick and prolonged neutralisation of stomach acidity with protective effect in respect to stomach mucous coat.23 cl, 3 dwg, 6 ex

Production method of low-water-soluble hard materials based on carboxyl-containing polysaccharides modified with aminosalicylic acid // 2343932
FIELD: chemistry.SUBSTANCE: used are films made of glycosaminoglycan conjugates with 4- or 5-aminosalicylic acids or alginate conjugates with 4- or 5-aminosalicylic acids or intermixed conjugates or mixed conjugates and at least one polymer chosen from group including carboxymethyl cellulose, glycosaminoglycan, alginate, gelatine, albumin with salicylate content not less than 50%. Specified mixtures are treated with 2-20% iron (III) chloride solution at room temperature within 1-5 minutes. Surface complex lowers water- and biological liquids solubility of the film.EFFECT: prolonged of biomaterial activity is provided.10 ex
Improved compositions and improvements associated therewith // 2317087
FIELD: medicine, pharmaceutical.SUBSTANCE: invention relates to solid composition for treatment of reflux esophagitis, gastritis, or ulcers, method for production thereof and uses in therapy. Claimed composition contains alginate, bicarbonate and/or carbonate, and poly(C1-C5-alkylene glycol) hawing molecular mass of at least 6000 in amount of 1-50 %.EFFECT: composition of decreased foam-forming properties and improved organoleptic characteristics.12 cl, 18 ex

ethod for treating rectal cancer // 2311909
FIELD: medicine, oncology.SUBSTANCE: in pre-surgical period in the 1st, 3d, 5th d of a 5-d-long irradiation course it is necessary to carry out a seance of distance gamma-therapy at single focal dosage (SFD) being 5 Gy at the background of a double intake of capecytabin at its daily dosage of 1.5 g/sq. m body surface. In the 2nd and 4th d at the background of a double intake of capecytabin at the same dosage, one should intrarectally introduce metronidasol at the rate of 10 g/sq. m body surface and after a 6-h-long exposure one should carry out a seance of distance gamma-therapy at SFD being 5 Gy. Moreover, metronidasol should be introduced as a composite mixture at the following ratios of the ingredients, weight%: metronidasol 12-22; sodium alginate 4-6; dimethyl sulfoxide 2; distilled water - up to 100. The innovation provides taking antilogarithms of the effect of radiomodifiers of different direction at the background of radiation therapy and, thus, the absence of locoregional relapses for the period of 2 yr, the decrease in the onset of distant metastases and the increased frequency in achieving radial pathomorphosis of degree III in the tumor.EFFECT: higher efficiency of therapy.1 ex
 
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