Into the form of capsules or similar small containers for oral use (A61J3/07)

Stable pharmaceutical composition for oral administration comprising levocetirizine, or pharmaceutically acceptable salt thereof and montelukast or pharmaceutically acceptable salt thereof // 2614382
FIELD: medicine, pharmacy.SUBSTANCE: this present invention relfers to a pharmaceutical composition in the form of a capsule for oral administration for asthma or allergic rhinitis prevention or treatment. The composition comprises: (a) the first fraction of particles in the form of mini-pill comprising levocetirizine, or pharmaceutically acceptable salt thereof and organic acid; and (b) the second fraction of particles in the form of mini-pill comprising montelukast or pharmaceutically acceptable salt thereof. The organic acid is citric acid, tartaric acid, succinic acid or ascorbic acid. The organic acid is present in the amount of 100 parts by weight per 100 parts of levocetirizine. The said first and second particle fractions are physically separated and filled into the capsule. A method for pharmaceutical capsule composition production is also described. The pharmaceutical composition of this invention inhibits the production of related contaminants of levocetirizine and montelukast and provides good stability.EFFECT: invention expands the product range of drugs for allergic rhinitis or asthma prevention or treatment.9 cl, 3 dwg, 4 tbl, 6 ex

Process of getting rosemary nanocapsules in sodium alginate // 2613883
FIELD: nanotechnology.SUBSTANCE: for shells of nanocapsules sodium alginate is used, and the rosemary powder is slowly added to a suspension of sodium alginate in petroleum ether in the presence of 0.01 g E472c as a surfactant, and then stirred at 1000 r/min and the ethyl acetate is poured, the resulting suspension is filtered and dried at room temperature, wherein the weight ratio of core: shell in nanocapsules is 1:1 or 1:3.EFFECT: simplification and acceleration of the process of producing the nanocapsules of rosemary, as well as increase their yield by weight.1 dwg, 3 ex

ethod for production "ks" swine fever vaccine nanocapsules in sodium alginate // 2613795
FIELD: biotechnology.SUBSTANCE: method includes dilution of 55 mg of "KS" vaccine were dissolved in 3 ml of petroleum ether and dispersed into a sodium alginate suspension in petroleum ether containing 550 mg of this polymer in the presence of 60 mg of E472s preparation as surfactant while stirring at 1000 rpm, then 5 ml of ethyl acetate is added, the precipitate is filtered and dried at room temperature.EFFECT: simplification and acceleration of "KS" vaccine nanocapsules production process, increasing their output by weight.1 dwg, 1 tbl, 3 ex

ethod for praparing nanocapsules of medicinal plants having sedative effect // 2613761
FIELD: pharmacology.SUBSTANCE: invention relates to chemical and pharmaceutical industry, and is a method for preparing nanocapsules of the medicinal plants having a sedative effect, characterized in that the tinctures of valerian, motherwort and anomalous peony are added to the suspension of sodium carboxymethyl cellulose in acetone in the presence of 0.01 g of E472s preparation as a surfactant, while stirring at 1300 rev/min, the prepared suspension is filtered and dried at room temperature, wherein the ratio of core: shell in case of preparing the motherwort tincture nanocapsules is 1:3, 1:1, 5:1 or 1:5, in the case of preparing the valerian tincture nanocapsules is 1:3, 1:1, 5:1, 1:5, in the case of preparing the anomalous peony tincture nanocapsules is 1:3, 1:5.EFFECT: invention allows to simplify and accelerate the method of preparing the nanocapsules and to increase the weight yield.3 dwg, 11 ex

Production method of metronidazole nanocapsules in konjac gum // 2613108
FIELD: nanotechnology.SUBSTANCE: metronidazole powder is added to konjac gum suspension in butanol and 0.01g of E472s, used as a surface-active substance, then 10 ml of carbon tetrachloride is added, the resulting suspension of nanocapsules is filtered and dried off, at that the weight ratio of core: shell in nanocapsules is 1:3, 1:1, 1:5 or 5:1.EFFECT: metronidazole nanocapsules production process simplification and acceleration, and also the weight yield increase.2 dwg, 5 ex

ethod of production of sodium hydrogen carbonate nanocapsules // 2612348
FIELD: nanotechnology.SUBSTANCE: sodium hydrogencarbonate is added to sodium alginate suspension in petroleum ether with the presence of E472c as a surface-active substance during agitation of 1,200 rpm, then, 5 ml of carbon tetrachloride is added, whereupon, the core:shell mass ratio is 1:1, 1:2, 1:3 or 1:5 on conversion to dry substance; the obtained suspension is filtered and dried at room temperature.EFFECT: nanocapsules manufacture process simplification, reduction of losses in the nanocapsules production, acceleration and weight yield increase.2 dwg, 5 ex

ethod of producing nanocapsules of metal salts in agar-agar // 2612025
FIELD: nanotechnology.SUBSTANCE: method is characterized in that 100 mg of metal salt (potassium iodide, magnesium, zinc or calcium carbonate, calcium chloride) is dispersed into a suspension of 100 or 300 mg of agar-agar in benzene in the presence of 0.01 g of E472s preparation as a surface-active agent while stirring at 1200 rev/min, followed by pouring of 5 ml chloroform. The molar ratio of core: sheath ratio is 1:1 or 1:3, then the resulting suspension is filtered and dried at room temperature.EFFECT: nanocapsules manufacture process simplification and acceleration and weight yield increase.11 ex, 3 dwg

ethod of production of ecocide nanocapsules in sodium alginate // 2611369
FIELD: nanotechnology.SUBSTANCE: ecocide C is added portionwise is added to sodium alginate suspension in hexane and 0.01 g of E472s while stirring 1000 r/min and then methylene chloride is poured in, the obtained suspension is filtered and dried at room temperature. The mass ratio core:shell in nanocapsules is 1:3, 1:1, 1:5 or 5:1.EFFECT: nanocapsules of ecocide C manufacture process simplification and acceleration and weight yield increase.2 dwg, 5 ex

ethod of production of metronidazole nanocapsules in sodium alginate // 2611368
FIELD: nanotechnology.SUBSTANCE: metronidazole powder is added to sodium alginate suspension in hexane and 0.01 g of E472s then acetone is added, the obtained suspension is filtered and dried. The mass ratio core:shell in nanocapsules is 1:3, 1:1, 1:5 or 5:1.EFFECT: nanocapsules of metronidazole manufacture process simplification and acceleration and weight yield increase.1 dwg, 5 ex

ethod of producing of microcapsules of tetracycline antibiotics in sodium alginatemethod of producing of microcapsules of aminoglycoside antibiotics in sodium alginate // 2611367
FIELD: nanotechnology.SUBSTANCE: an antibiotic powder is added to sodium alginate suspension in petroleum ether and 0.01 g of E472s drug as a surface-active substance, then, 5 ml of carbon tetrachloride is added, the obtained suspension is filtered and dried. The mass ratio core:shell in nanocapsules is 1:3 or 1:1.EFFECT: nanocapsules of antibiotics manufacture process simplification and acceleration and weight yield increase.2 dwg, 11 ex
Drug based on tetrametiltetraazobitsiklooktandion and method for its production // 2611194
FIELD: pharmacy.SUBSTANCE: here is a description of dosage form of tetrametiltetraazobitsiklooktandion, additionally containing a filler, granulating agent, lubricant, disintegrant, flavoring agent in certain weight ratios. Methods of preparing of the said dosage form are also described.EFFECT: preparation of the dosage form without defects in manufacture and storage and with improved taste characteristics.11 cl, 3 tbl

ethod for producing nanocapsules containing biopag-d and brilliant green // 2609826
FIELD: chemistry.SUBSTANCE: brilliant green in the amount of 2.5 ml added to 2.5 g of biopag-D, the resulting mix is added to 2.5 g or 7.5 g of carboxymethyl cellulose suspension in petroleum ether and 0.05 g of surfactant E472; the resulting mix is stirred using a magnetic stirrer, the precipitated nanocapsules are filtered off, washed with petroleum ether and dried.EFFECT: accelerated and simplified process of pcoducing nanocapsules containing biopag-D and brilliant green, improved mass yield.1 dwg, 3 ex

ethod for obtaining nanocapsules of medications of penicillin goup in sodium alginate // 2609824
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to method for obtaining nanocapsules of medications of penicillin group, selected from ampicillin, sodium salt of benzylpenicillin or amoxicillin. The claimed method is characterised by the fact that 0.01 g of preparation E472c is added to 0.5 g of sodium algenate in petroleum ether as surface active substance, 0.5 g of antibiotic powder is added to obtained suspension in small portions, with the following addition of 5 ml of chloroform, obtained suspension of nanocapsules is filtered and dried.EFFECT: invention ensures simplification and acceleration of process of obtaining nanocapsules of penicillin group medications, as well as increase of their output by weight.3 dwg, 7 ex

ethod for producing ciprofloxacin hydrochloride nanocapsules // 2609742
FIELD: chemistry.SUBSTANCE: invention relates to a method for producing ciprofloxacin hydrochloride nanocapsules. According to the invention ciprofloxacin hydrochloride powder is added to the suspension of gellan gum in butanol and 0.01 g of E472c agent, followed by chloroform, and the resulting nanocapsule suspension is filtered and dried. The core : shell ratio in the nanocapsules was 1:3, 1:1, 1:5 or 5:1.EFFECT: quick and easy process of producing ciprofloxacin hydrochloride nanocapsules and increase of mass yield.1 dwg, 5 ex

ethod for production of "ks" vaccine nanocapsules from swine fever covered by sodium carboxymethylcellulose // 2609741
FIELD: medicine.SUBSTANCE: invention refers to the method for preparation of "KS" vaccine nanocapsules against swine fever. The peculiarity of the said method is that the "KS" vaccine is dissolved in petroleum ether, and then dispersed into a suspension of sodium carboxymethylcellulose in petroleum ether in the presence of E472s preparation as a surfactant while stirring 1000 rev/min, then butyl chloride is added, nanocapsules precipitation is filtered and dried at room temperature.EFFECT: invention provides simplification and acceleration of the production process of the "KS" vaccine nanocapsules, as well as increase of their yield by weight.1 dwg, 3 ex

ethod for preparation of nanocapsules of aminoglycoside antibiotics in gellan gum // 2609740
FIELD: medicine.SUBSTANCE: invention refers to a method for preparation of nanocapsules with aminoglycoside antibiotic selected from kanamycin, amikacin or gentamicin sulphate. The said method is characterized by application of gellan gum as a shell for the nanocapsules, wherein the aminoglycoside antibiotic is added by portions to a E472s containing gellan gum suspension in butanol at a aminoglycoside antibiotic:gellan gum weight ratio of 1:1 or 1:3, the mixture is stirred, methylene chloride is added and the resulting nanocapsule suspension is filtered, washed with methylene chloride and dried, the process takes 15 minutes.EFFECT: invention provides simplification and acceleration of the production process of the aminoglycoside antibiotic nanocapsules, as well as increase of their yield by weight.3 dwg, 7 ex

ethod for producing resveratrol nanocapsules in gellan gum // 2609739
FIELD: chemistry.SUBSTANCE: invention relates to a method for producing resveratrol nanocapsules. According to the invention resveratrol is added to the suspension of gellan gum in butanol in the presence of glycerol ester with one or two molecules of food grade a fatty acid and one or two molecules of citric acid under stirring at 1000 rev./min., followed by ethyl acetate. The resulting suspension of nanocapsules was filtered and dried at room temperature. The core : shell ratio in the nanocapsules was 3:1 or 1:5.EFFECT: quick and easy process of producing resveratrol nanocapsules and increase of mass yield.1 dwg, 3 ex

ethod of production of jujube nanocapsules in sodium alginate // 2609196
FIELD: nanotechnologies.SUBSTANCE: invention refers to the area of nanotechnologies, particularly to the method of production of nanocapsules, and describes the method of production of jujube nanocapsules. The method is characterized by the fact that jujube is used as a core and sodium alginate is used as a shell; during the method implementation, the powder from jujube berries is added to sodium alginate suspension in petroleum ether with the presence of E472c as a surface-active substance during agitation of 1,300 rpm, then, 5 ml of carbon tetrachloride as a precipitator is added, whereupon, the core/shell mass ratio is 1:1 or 1:3 on conversion to dry substance; the obtained suspension is filtered and dried at room temperature.EFFECT: method provides simplification and acceleration of the production process of nanocapsules, as well as reduction of losses during the production process.1 dwg, 3 ex
Production method for green tea extract nanocapsules in chitozan // 2609195
FIELD: food industry.SUBSTANCE: invention relates to the method of green tea extract nanocapsule production. The said method implies that green tea extract is added to the suspension of chitozan in petroleum-ether in the presence of glycerol ester with one-two molecules of fatty edible acids and one-two molecules of citric acid as surface active agent while mixing at 1300 rpm, afterwards acetone is added, the obtained nanocapsule suspension is filtered and dried at room temperature; herewith the mass ratio kernel/shell in nanocapsules accounts for 1:3, 1:1 or 1:5.EFFECT: invention provides for simplified and faster production of green tea extract nanocapsules, and for increase of their output by weight.2 dwg, 4 ex

ethod of producing nanocapsules of adenine in carrageenan // 2607654
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing nanocapsules of adenine. Specified method is characterized by that carrageenan in benzene is added with glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as a surfactant, the produced mixture is stirred, added with adenine powder, after formation of an independent solid phase is slowly added with petroleum ether, the produced suspension of nanocapsules is filtered, washed with petroleum ether and dried, herewith the ratio of nucleus/shell in the nanocapsules makes 1:3, 1:1 or 5:1.EFFECT: invention provides faster and easier process of nanoencapsulation of adenine, as well as higher mass output.1 cl, 1 dwg, 4 ex

ethod of producing nanocapsules of adaptogens in carrageenan // 2607386
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing nanocapsules of adaptogen. Specified method is characterized by that eleutherococcus or ginseng extract is added to the suspension of carrageenan in isopropanol in presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid, then hexane is added, the produced suspension of nanocapsules is filtered and dried, herewith the ratio of nucleus/shell in the nanocapsules makes 1:3 or 5:1.EFFECT: invention provides faster and easier process of nanoencapsulation, increasing mass output.1 cl, 2 dwg, 5 ex

ethod of producing nanocapsules of dry spinach extract // 2606854
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, namely to method of producing nanocapsules of dry spinach extract in sodium carboxymethyl cellulose. Method involves dispersion of dry spinach extract in solution of sodium carboxymethyl cellulose in benzene in ratio 1:1–3 in presence of E472c as surfactant, while stirring at rate of 1,000 rpm. Then precipitator (diethyl ether) is added and obtained suspension is filtered. Nanocapsules are washed with diethyl ether and ready product is dried at room temperature. Method provides simplifying and accelerating process of nanocapsules production, reduces losses, when producing nanocapsules.EFFECT: invention can be used, in particular, in cosmetic and food industries.1 cl, 2 dwg, 3 ex

ethod of producing tannin nanocapsules // 2606589
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing nanocapsules of tannin. Said method is characterized by that 1 g of tannin is added to a suspension of 1 g low-esterified apple pectin in petroleum ether in presence of 0.01 g glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid while mixing at 1,000 rpm, then 6 ml of ethyl acetate is added, produced suspension of nanocapsules is filtered and dried at room temperature.EFFECT: invention provides faster and easier process of nanoencapsulation of tannin, as well as higher weight yield.1 cl, 2 dwg, 6 ex

ethod of producing nanocapsules of dry girasol extract // 2605614
FIELD: manufacturing technology.SUBSTANCE: invention relates to a method of producing nanocapsules of dry girasol extract in sodium carboxymethyl cellulose. Said method is characterized by that a suspension of sodium carboxymethyl cellulose in benzene is added with preparation E472c as a surfactant, the produced mixture is stirred, added with dry girasol extract, then acetonitrile is added; the prepared suspension of nanocapsules is filtered, washed with acetonitrile and dried, herewith the weight ratio of girasol extract:sodium carboxymethyl cellulose in the nanocapsules makes 1:3, 1:1, 1:5 or 5:1.EFFECT: invention provides simplifying and accelerating the process of girasol nanoencapsulation, as well as higher weight yield.1 cl, 1 dwg, 5 ex

ethod of producing nanocapsules of medicinal plants with sedative action in agar-agar // 2605613
FIELD: pharmaceutics.SUBSTANCE: invention relates to method of producing nanocapsules of medicinal plants with sedative effect. Above method is characterized by that 5 ml of motherwort or valerian infusion or 10 ml of anomala rootstock infusion are added to agar-agar suspension in benzene, containing 1 or 3 g of said polymer in presence of 0.01 g of preparation E472c as surfactant while mixing at 1,300 rpm, 10 ml of butyl chloride are then added, obtained suspension of nanocapsules is filtered and dried at room temperature.EFFECT: invention simplifies and speeds up process of producing nanocapsules and increases mass output.1 cl, 2 dwg, 7 ex

ethod of producing nanocapsules with group b vitamins // 2605596
FIELD: pharmaceutics.SUBSTANCE: invention relates to method of producing nanocapsules of vitamins B in sodium alginate. Said method is characterized by fact, that sodium alginate used is as shell, and core is group B vitamins, at weight ratio of nucleus:shell of 1:3 or 1:1, wherein vitamin is added in sodium alginate suspension in petroleum ether in presence of preparation E472c as surfactant while mixing at 1,300 rpm, then ethyl acetate is added, obtained suspension is filtered and dried at room temperature.EFFECT: invention provides simplification and acceleration of process of producing vitamin nanocapsules, as well as higher weight yield.1 cl, 2 dwg, 11 ex

ethod of producing nanocapsules of medicinal plants with antispasmodic effect // 2605594
FIELD: medicine.SUBSTANCE: invention relates to method of producing nanocapsules of medicinal plants with antispasmodic action. Said method is characterized by fact, that mint tincture is added to suspension of sodium carboxymethyl cellulose in methyl ethyl ketone in presence of 0.01 g of preparation E472c as surfactant while mixing at 1,300 rpm, obtained suspension is filtered and dried at room temperature, wherein weight ratio of nucleus:shell is 1:3, or 1:1 or 3:1 or 1:5, or 5:1.EFFECT: invention provides simplification and acceleration of process of nanoencapsulation of mint tincture and higher weight yield.1 cl, 2 dwg, 6 ex

ethod of producing nanocapsules of medicinal plants having sedative action in carrageenan // 2605273
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, namely to method of producing nanocapsules, and describes a method of producing nanocapsules of medicinal plants, with sedative effect. Method is characterised by that 5 ml of the infusion of valerian, motherwort or 10 ml anomalous peony added to the suspension of carrageenan in petroleum ether in the presence of 0.01 g E472c as surfactant at mixing 1,300 rot/min, the weight ratio nucleus: shell in terms of dry substance makes 1:1, or 1:3, obtained suspension is filtered and is dried at room temperature.EFFECT: method provides simplifying and accelerating the process of nanoencapsulation, while reducing accompanying loss.1 cl, 2 dwg, 6 ex

ethod of producing kinetin nanocapsules // 2603460
FIELD: nanotechnology.SUBSTANCE: invention relates to method of producing kinetin nanocapsules. Said method is characterized by fact, that glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid is added to carrageenan in petroleum ether, mixture is stirred, kinetin powder is added, after formation of independent solid phase benzene is added slowly drop-by-drop, obtained suspension of nanocapsules is filtered, washed with benzene and dried, wherein weight ratio of nucleus/shell of nanocapsules makes 1:3, or 1:1, or 5:1.EFFECT: invention provides simplifying and accelerating of kinetin nanoencapsulation process and higher weight yield.1 cl, 1 dwg, 4 ex

ethod of producing nanocapsules of quercetin and dihydroquercetin // 2603458
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, namely to method of producing nanocapsules, and describes method of producing adaptogen nanocapsules. Method is characterized by fact, that quercetin or dihydroquercetin is added to suspension of xanthan gum in hexane in presence of 0.01 g of E472c surfactant, weight ratio nucleus:shell in terms of dry substance makes 1:1 or 1:3, then acetonitrile is added, while mixing at 1,000 rpm, obtained suspension is filtered and is dried at room temperature.EFFECT: method provides simplifying and accelerating the process of nanoencapsulation, while reducing accompanying loss.1 cl, 2 dwg, 5 ex

ethod of producing adaptogen nanocapsules in agar-agar // 2603457
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, namely to method of producing nanocapsules, and describes method of producing adaptogen nanocapsules. Method is characterized by fact, that extracts of eleuterococcus, ginseng, chinese magnolia vine, aralia or rhodiola rosea are added to agar-agar suspension in isopropanol in presence of E472c as surfactant, while mixing at 1,300 rpm, then 1,2-dichloroethane is added as precipitant, weight ratio nucleus:shell in terms of dry substance makes 1:1, 1:3 or 5:1, obtained suspension is filtered and is dried at room temperature.EFFECT: method provides simplifying and accelerating the process of nanoencapsulation, while reducing accompanying loss.1 cl, 3 dwg, 11 ex

ethod of producing diclofenac capsules // 2602681
FIELD: pharmaceutics.SUBSTANCE: method of producing diclofenac capsules. Mixture of diclofenac and polyethylene glycol with molecular weight 2,000±400 at weight ratio 1:1-1.5 is dissolved in ethanol at weight ratio of mixture and ethanol 1:0.3-0.6 at temperature of 80±5 °C. Obtained solution at weight ratio of 1:1.75-2 is used for granulation of excipients' mixture: kollidone 90F, polyplasdone XL, starch-1500, lactose, microcrystalline cellulose-101, taken at weight ratio (1:1.9-2.0; 4.6-11.7; 11.7-12.0; 36.0-36.1). Magnesium stearate is added to obtained granulate in amount of 0.5-1.5 % and aerosil of grade 300 is also added in an amount of 2.5-7.5 % of granulate weight. Granulate is dosed in solid gelatinous acid-resistant capsules.EFFECT: method of producing capsules according to the invention allows to improve bioavailability of non-salt form of diclofenac.1 cl, 3 tbl

ethod of producing nanocapsules of medicinal plants with immunostimulating effect in carrageenan // 2602168
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, namely to method of producing nanocapsules and describes method of producing nanocapsules of medicinal plants with immunostimulating effect. Method is characterized by that echinacea tincture is added to suspension of carrageenan in benzene in presence of 0.01 g of E472c as surfactant, while stirring at 1,300 rpm, wherein core:coating weight ratio in terms of dry substance is 1:1 or 1:3, or 3:1; obtained suspension is filtered and dried at room temperature.EFFECT: method provides simplifying and accelerating of process of nanoencapsulation, while reducing accompanying loss.1 cl, 1 dwg, 4 ex

ethod of producing nano capsules of medicinal plants having immunostimulating effect // 2602167
FIELD: technological processes.SUBSTANCE: invention relates to method of nano capsules with echinacea tincture producing. Said method is characterized by, that echinacea tincture is added to of sodium carboxymethyl cellulose in petroleum ether suspension in presence of 0.01 g of E472c preparation with mixing at 1,300 rpm, obtained suspension of nano capsules is filtered and dried at room temperature, wherein nucleus/shell weight ratio in nano capsules makes 1:3, 1:1, 3:1, 1:5 or 5:1.EFFECT: invention simplifies and accelerates process of echinacea nano capsules producing and increases their mass output.1 cl, 1 dwg, 6 ex

ethod of producing nano capsules of medicinal plants having immunostimulating effect in agar-agar // 2602166
FIELD: nanotechnology; pharmaceutics.SUBSTANCE: invention relates to a method of producing nanocapsules with echinacea tincture. Above method is characterized by adding echinacea tincture to agar-agar suspension in benzol in presence of 0.01 g of E472c preparation as surfactant, while mixing at 1,300 rpm, filtering the produced suspension of nanocapsules and drying at room temperature, wherein nucleus/shell weight ratio of nanocapsules is 1:3, 1:1, 5:1 or 3:1.EFFECT: invention simplifies and speeds up process of producing echinacea nanocapsules and increases weight yield.1 cl, 2 dwg, 5 ex

ethod of producing medicinal plant nanocapsules having cardioactive action in agar-agar // 2602165
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing nanocapsules with Hawthorn tincture. Above method is characterized by adding the Hawthorn tincture to agar-agar suspension in hexane in the presence of 0.01 g of the E472 preparation as a surfactant while mixing of 1,300 rpm, filtering the produced suspension of nanocapsules and drying at room temperature, wherein nucleus/shell weight ratio of nanocapsules is 1:3, 1:1 or 5:1.EFFECT: invention simplifies and speeds up process of producing nanocapsules of Hawthorn tincture and increases weight yield.1 cl, 1 dwg, 1 ex

ethod of producing a pharmaceutical erythromycin composition // 2600924
FIELD: medicine.SUBSTANCE: invention relates to medicine and chemical-pharmaceutical industry and a method of producing a new pharmaceutical erythromycin composition in the form of capsules for use as a broad-spectrum antibiotic. Method of producing a pharmaceutical composition for treating bacterial and protozoal infectious diseases in the form of enterosoluble erythromycin-based capsules comprises mixing erythromycin base or its pharmaceutically acceptable salt with pluronic at a ratio of 70:30, micronization of produced mixture, addition of auxiliary substances, repeated micronization and filling gelatine capsules with the produced mixture. Kolliphor P 188, Kolliphor P 407 or their mixture are used as a pluronic.EFFECT: method is high-tech, and the produced composition and dosage form have high bioavailability of about 70 %, sufficient for considerable reduction of preparation dose (up to 2 g a day) and maintaining a stable erythromycin concentration in blood.6 cl, 3 ex, 2 tbl

ethod of producing nanocapsules of green tea extract in pectin // 2599843
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, in particular, to a method of producing nanocapsules of green tea, characterised by using high-or low-etherified apple or citrus pectin as a shell, and by using green tea extract as a core, the method comprises adding the green tea extract to the pectin suspension in ethanol in the presence of 0.01 g of E472c surfactant, core: shell weight ratio in terms of dry substance is 1:3, then while mixing at 1,300 rpm ethyl acetate is being added, the obtained suspension is being filtered and dried at room temperature.EFFECT: method provides simplifying and accelerating the process of nanoencapsulation, while reducing accompanying loss.1 cl, 1 dwg, 5 ex

ethod of producing medicinal plant nanocapsules having cardioactive action in carrageenan // 2599842
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnology, in particular, to a method of producing nanocapsules having cardioactive action, and describes a method, characterized by that carrageenan is used as a coating, and hawthorn infusion is used as a core, the method comprises adding the hawthorn infusion to the carrageenan suspension in benzene in the presence of surfactant E472c at mixing 1,300 rpm, core: coating weight ratio in terms of dry substance is 1:1 or 1:3, or 3:1, obtained suspension is filtered and is dried at room temperature.EFFECT: method provides simplifying and accelerating the process of nanoencapsulation, while reducing accompanying loss.1 cl, 1 dwg, 4 ex

ethod of aminoglycoside antibiotics in sodium alginate nano-capsules producing // 2599841
FIELD: medicine.SUBSTANCE: invention relates to nanotechnology and medicine. Described is method of aminoglycoside antibiotics in sodium alginate envelope nano-capsules producing. According to method according to invention aminoglycoside antibiotic is added in portions into sodium alginate suspension in benzene, containing E472c preparation as surfactant with mass ratio of aminoglycoside antibiotic: sodium alginate of 1:1 or 1:3. Mixture is stirred, then methyl ethyl ketone is added. Obtained suspension of nano-capsules is filtered, washed with methyl ethyl ketone and dried. Process is performed within 15 minutes.EFFECT: method according to invention provides simplification and acceleration of nano-capsules producing process in sodium alginate and increases mass output.1 cl, 1 dwg, 7 ex

ethod of rosehip flavonoids nano capsules producing // 2599485
FIELD: pharmaceutics.SUBSTANCE: invention relates to a method for preparing nanocapsules of rose hip flavonoids. Above method is characterized by that rosehip flavonoids are dispersed in sodium alginate in isopropanol suspension in the presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid with mixing at 1,300 rpm, then butyl chloride is added, nano capsules precipitate is filtered and dried at room temperature, wherein nucleus/shell weight ratio in nano capsules makes 1:3, 1:1 or 5:1.EFFECT: invention provides simplification and acceleration of rosehip flavonoids nano encapsulation process, as well as higher weight yield.1 cl, 1 dwg, 1 tbl, 4 ex

ethod of producing nanocapsules of green tea extract // 2599484
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing nanocapsules of green tea extract. Said method is characterised by adding green tea extract to a sodium alginate suspension in butanol in presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid while mixing at 1,300 rpm, further, flushing ethyl acetate, obtained suspension of nanocapsules is filtered and dried at room temperature, wherein weight ratio of core: cladding of nanocapsules is 1:3, 1:1 or 1:5.EFFECT: invention simplifies and speeds up process of producing nanocapsules of green tea extract and increases mass output.1 cl, 1 dwg, 4 ex

ethod of producing nanocapsules of betulin // 2599483
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing nanocapsules of betulin. Said method is characterised by dispersing betulin powder in sodium alginate suspension in benzene in presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid while mixing at 1,300 rpm, further, flushing butyl chloride, obtained suspension of nanocapsules is filtered and dried at room temperature, wherein weight ratio of core/cladding in nanocapsules is 1:3 or 1:1.EFFECT: invention simplifies and speeds up process of producing betulin nanocapsules and increases mass output.1 cl, 1 dwg, 3 ex

ethod of medicinal plants nano capsules producing having cardioactive effect // 2599481
FIELD: medicine.SUBSTANCE: invention relates to method of Hawthorn tincture nano capsules producing. Above method is characterized by that Hawthorn tincture is added in sodium alginate in petroleum ether suspension in the presence of glycerol ester with one or two molecules of edible fatty acids and one or two citric acid molecules while mixing at 1,300 rpm, then methylene chloride is added, produced nano capsules suspension is filtered and dried at room temperature.EFFECT: invention provides simplifying and accelerating process of nano capsules producing and increases their mass output.1 cl, 1 dwg, 3 ex

ethod of producing nanocapsules of ciprofloxacin hydrochloride in sodium alginate // 2599007
FIELD: medicine.SUBSTANCE: invention relates to nanotechnology and medicine. Method of producing nanocapsules of ciprofloxacin hydrochloride in sodium alginate envelope is described. According to the method of invention ciprofloxacin hydrochloride powder is added to sodium alginate suspension in benzene, containing 0.01 g of preparation E472c as surfactant. Then butyl chloride is added. Obtained suspension of nanocapsules is filtered and dried. Process is performed at 25 oC during 15 minutes.EFFECT: method provides simple and fast process of producing nanocapsules and increases mass output.1 cl, 1 dwg, 5 ex

ethod for producing nano-capsules of medicinal plants having sedative action // 2597151
FIELD: pharmaceutics.SUBSTANCE: invention relates to a method for producing nano-capsules of medicinal plants having sedative action. Above method is includes the following: Valerian liqueur, motherwort liqueur or anomala rootstock liqueur are added into sodium alginate suspension in petroleum ether in the presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as surfactant, then sulphur ether is added, the obtained suspension of nano-capsules is filtered and dried at room temperature.EFFECT: invention provides simplification and acceleration of the process of nano-encapsulation of medicinal plants, as well as higher weight yield.1 cl, 2 dwg, 4 ex

ethod of producing creatine nanocapsules in gellan gum // 2596485
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing nanocapsules, and describes a method of producing creatine nanocapsules, characterized by the fact that gellan gum is used as an enclosure, and creatine is used as a core, in the method creatine is dispersed into suspension of gellan gum in hexane in the presence of surface-active agent e472c, wherein weight ratio core: enclosure on conversion to dry substance is 1:1 or 1:3, then, while stirring ethyl acetate is being added, obtained suspension is filtered and is dried at room temperature.EFFECT: method provides simplifying and accelerating the process of nanoencapsulation, while reducing accompanying loss.1 cl, 1 dwg, 3 ex

ethod for producing adaptogen nanocapsules // 2596482
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing nano-capsules of adaptogens in konjac gum. Above method is characterized by that adaptogen is added to the suspension of konjak gum in butanol in the presence of complex glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as a surfactant, then ethyl acetate is added, the produced suspension of nano-capsules is filtered and dried, the ratio of nucleus/shell of nano-capsules makes 1:3 or 5:1.EFFECT: invention provides simplification and acceleration of the process of nano-encapsulation of immunomodulators, as well as higher weight yield.1 cl, 5 dwg, 8 ex

ethod of producing nanocapsules of adaptogens in carrageenan // 2596479
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing nano-capsules of adaptogenes. Said method is characterised by that adaptogen is added to suspension of carrageenan in ethanol in presence of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as surfactant, then chloroform is added, obtained suspension of nanocapsules is filtered and dried, wherein ratio of nucleus/shell in nanocapsules is 1:3 or 5:1.EFFECT: invention simplifies and accelerates process of producing nanocapsules of adaptogens, as well as higher weight yield.1 cl, 2 dwg, 8 ex

ethod of producing potassium iodide nanocapsules in pectin // 2595825
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing potassium iodide nanocapsules in pectin. Specified method is characterized by that the suspension of low-or highly esterified apple or citrus pectin in ethanol is added with the preparation E472c, obtained mixture is stirred, add potassium iodide, than add tetrachloride carbon, the received suspension of nanocapsules is filtered, washed with tetrachloride carbon and dried.EFFECT: invention provides simplifying and accelerating of receiving of potassium iodide nanocapsules, and also increase in their exit on weight.1 cl, 1 dwg, 5 ex
 
2550891.
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