Human necessities (A)

A            Human necessities(303198)
ethod of long-term individual control of arterial pressure and pulse // 2607792
FIELD: medicine.SUBSTANCE: invention refers to medicine, biorhythmology. Method of long-term self-control of arterial pressure and pulse involves measuring of AP and pulse every hour in 5 replications every 2 minutes for 10 minutes: 1st measurement is carried out immediately after tonometer switching on, 2nd – at 2 minute, 3d – at 4 minute, 4th – at 6 minute, 5th – at 8 minute during 16 hours: from 7.45 to 23. During measuring it is necessary to take into account biological rhythms – measurement is performed, when the Moon at passes the same constellation annually in same months twice – in winter and summer, in same or neighboring lunar day. Measurement is made accurately 15 minutes before end of every hour. From obtained data average daily values of AP and pulse are calculated, plot dependence of SISav – age (year) and PULav – age (year) are drawn.EFFECT: method allows any adult during whole life to perform long-term individual control of arterial pressure and pulse and timely respond to their change.1 cl, 6 ex, 6 tbl, 6 dwg
Attenuated strain "msc-2015 vniivvim" of african swine fever virus serotype viii for virology and molecular-genetic analysis // 2607791
FIELD: medicine.SUBSTANCE: invention relates to virology. Attenuated strain “SKA-2015 VNIIVViM” of african swine fever virus serotype VIII is disclosed. Strain is produced by intermittent passages and selection of virulent strain "Stavropol 01/08" in primary cell culture of LS and transplantable hybrid cell line A4C2/9k and it is deposited in State collection of strains of microorganisms GNU Rosselhozakademii VNIIVViM under No. 1847.EFFECT: strain "MSC-2015 VNIIVViM" can be used during virological, molecular-genetic research, studying immunogenesis of disease, development of diagnostic and vaccine preparations.1 cl, 4 tbl, 4 ex
Novel pyrrole compounds, synthesis method thereof and pharmaceutical compositions containing same // 2607788
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I) possessing inhibitory activity on Bcl-2 family proteins. In formula (I) (I) A1 is hydrogen, (C1-C6)polyhaloalkyl group or (C1-C6)alkyl group, A2 is hydrogen, (C1-C6)polyhaloalkyl group, (C1-C6)alkyl group or cycloalkyl group, T denotes a hydrogen atom, (C1-C6)alkyl group, optionally substituted with one-three halogen atoms, group (C1-C4)alkyl-NR1R2 or group (C1-C4)alkyl-OR6, R1 and R2 each independently from each other is a hydrogen atom or (C1-C6)alkyl group, or R1 and R2 form with a nitrogen atom bearing them, heterocycloalkyl, R3 is (C1-C6)alkyl group, cycloalkyl group, heterocycloalkyl group, aryl group or heteroaryl group, wherein one or more carbon atoms of previous groups or their possible substitutes can be deuterated, R4 is an aryl group or heteroaryl group, wherein one or more carbon atoms of previous groups or their possible substitutes can be deuterated, R5 is hydrogen or halogen atom, R6 is a hydrogen atom or a linear or branched (C1-C6)alkyl group, Ra, Rb, Rc and Rd each independently from other represents hydrogen, linear or branched (C1-C6)alkyl, halogen atom, a linear or branched (C1-C6)alkoxy group, hydroxy group, R7-CO-NH-(C0-C6)alkyl-, R7-SO2-NH-(C0-C6)alkyl-, R7-NH-CO-NH-(C0-C6)alkyl-, R7-O-CO-NH-(C0-C6)alkyl-, or substitutes of pair (Rb, Rc) form together with carbon atoms carrying them, a ring consisting of 5–6 ring members, which may contain 1–2 oxygen atoms, R7 is hydrogen, linear or branched (C1-C6)alkyl, aryl or heteroaryl. Invention also relates to methods of producing compounds of formula (I), to a pharmaceutical composition, use of a pharmaceutical composition for preparing a drug, use of compound of formula (I) for preparing a drug.EFFECT: obtaining novel compounds of formula (I) possessing inhibitory activity on Bcl-2 family proteins.37 cl, 2 tbl, 473 ex
Biological product for stimulating the growth of plants and their protection against phytopathogens on the basis of strains of trichoderma, strains of trichoderma for the production thereof (variants), method for producing a biological product on the basis of such strains // 2607785
FIELD: biotechnology.SUBSTANCE: group of inventions relates to biotechnology and can be used to create bioprotection of plants against phytopathogens and to stimulate their growth. Group of inventions comprises the strains of the fungus of Trichoderma longibrachiatum species (3 options); biological product for stimulating the growth of plants and their protection against phytopathogens on the basis of these strains and the method for producing a biological product. Strains of the Trichoderma longibrachiatum fungus are deposited at the ARRIAM FSBSI under registration numbers: RCAM 03324, RCAM 03323, RCAM 03325 respectively. Biological product contains spores and fragments of mycelium of above strains from 2×109 to 4×109 CFU/cm3; has antagonistic activity against phytopathogenic fungi of the Fusarium and Cladosporium species. Method of producing a biological product involves a two-stage joint cultivation of strains in a quantitative ratio of 1:1:1 consistently on two nutrient media for 4–5 days. This group of inventions provides increase in seed germination on 4–15 % and the increase of linear sizes of plants on 0.5–24 %.EFFECT: increased seed germination and the increase of linear sizes of plants.5 cl, 2 tbl, 5 ex
Ti fanny beverage // 2607784
FIELD: food industry.SUBSTANCE: invention relates to food products, specifically to tea-based cooled beverages. Beverage contains: 1.5÷1.8 % flavoured tea concentrate; 40÷45 % treated water, 4÷5.5 % fruit syrup, 7÷13 % topping and balance is ice. Topping used can be bursting bubbles with taste inside, coconut pieces, assorted jelly fruit.EFFECT: invention provides high taste properties of a tea-based refreshing beverage, and enables to widen range of beverages and preserve taste for a long time.1 cl
ethod of molded fish product manufacture // 2607783
FIELD: food industry.SUBSTANCE: method involves preparation of fish mince, preparation of auxiliary materials and spices, composing and cutting the mixture, injection of the ready mince into a casing, settling with further boiling, smoking and cooling. Mince preparation involves separation of salmon back part. Additional auxiliary materials and ingredients used are multifunctional mixtures, a flavouring agent and a flavouring mixture. After cooling the ready product is applied with starting culture of microorganisms by spraying with subsequent fermentation for not longer than 4 hours. All the components are used at the specified components ratio.EFFECT: invention ensures production of molded products from secondary fish resources formed after salmon fishes filleting.3 cl, 2 tbl, 2 ex
Device for rescue of people in case of fire // 2607781
FIELD: security.SUBSTANCE: invention relates to rescue service and is intended for evacuation of people from high-rise buildings in case of fire or other emergency situations. Device for rescue of people in case of fire comprises a frame, fixed on the building wall in interfloor space under the window aperture, working platform, front board, two side boards and locking mechanism, side boards are folding, and the device contains a sliding mechanism, which is a combination of three rods on each lateral side. First rod is fixed by a movable joint with its one end on the frame, second rod is fixed by a movable joint with its one end on the working platform, second ends of the first and second rods are fixed by a movable joint with each other, third rod is fixed by a movable joint with its one end on the front board, and with its other end - on the second rod.EFFECT: invention provides higher reliability of design due to distribution of load on attachment of working platform to the frame and on the rod of sliding mechanism.4 cl, 3 dwg
Automated tightening shoe (versions) // 2607779
FIELD: footwear.SUBSTANCE: invention relates to an automated tightening shoe with a single crisscrossed lace connected to top outer surface, wherein tightening mechanism includes a cylindrical side surface and continuous passage through axle with two outlet holes along side surface, drive wheel, rigidly connected with axle and protruding from shoe; a string passing through said passage, and two outlet holes made in axle passing along outer surface of parts of shoe top parts, with free ends of string, connected together and attached to an external point on shoe so that string forms a continuous loop; wherein a ratchet wheel is functionally connected with axle, engaged with dog of release lever, preventing rotation of axle in opposite direction, to prevent loosening of string; release means, functionally connected with protective means for selective disconnection of protective means, in order to allow rotation of axle in opposite direction to loosen middle and lateral parts of shoe top.EFFECT: technical result consists in automatic tightening of shoes.41 cl, 36 dwg
ethod of therapeutic-preventive agent delivery articles production // 2607777
FIELD: materials.SUBSTANCE: layered material from non-woven materials, including fine solid particles connected to it, is produced by deposition method, using which delivery to approximately 60 g/m2 of solid particles to substrate is possible. Solid particles can be applied onto substrate by means of powder application plant.EFFECT: layered material can be used in absorbent items for personal use, such as diapers, female sanitary pads, bandaging materials, mattress pads, etc.11 cl, 15 dwg, 4 tbl
Gem stone frame fastening in stone // 2607776
FIELD: jewelry industry.SUBSTANCE: invention relates to jewelry industry. Carcass fastener comprises, at least, two parts, forming base with gluing. At least, one of base parts contains, at least, one recess, each of which is made with through hole, and in each of recesses jewel element is arranged, made in form of jewelery insert encase into metal, made with pin in jewelery element lower part. Pin is inserted into recess through hole and rigidly attached to fastening element from base part other side, made with lateral dimension, exceeding recess through hole diameter, which prevents jewelry element falling out of recess after attachment. At least, one of base parts is made with grooves and/or recesses on glued surface, in assembled state providing hidden arrangement of jewelry article base bearing frame elements inside them, as well as jewelry elements fasteners and pins.EFFECT: improved operational characteristics of jewelry article due to jewelry article increased fastening strength in base, with simultaneous provision of hidden from view base frame fastening with jewelry element in jewelry article.7 cl, 14 dwg
Extraction system with cartridge chamber // 2607773
FIELD: manufacturing technology.SUBSTANCE: invention relates to a system containing a cartridge containing beverage ingredient, and device for ingredient infusion in the cartridge by supplying liquid into the cartridge for infusion, for example, heated water. Proposed device comprises front and rear downstream along the external cartridge elements moved relative to each other between open position to introduce and/or removing cartridge and the closed position to form the infusion chamber enclosing the cartridge during infusion. Infusion chamber provides limited space for expansion, which is not filled with cartridge prior to liquid fed into the cartridge in closed position of the elements enclosing the cartridge and is filled after the cartridge expansion caused by the ingredient under the influence of the liquid for infusion.EFFECT: providing maximum cartridge filling with ingredient and minimizing super extraction.16 cl, 7 dwg
Smoking article (versions) // 2607772
FIELD: tobacco industry.SUBSTANCE: invention relates to a smoking article, comprising a smoking part and a mouthpiece, smoking part comprises a rod made of material which forms an aerosol, heat-conducting shell and fuel layer, wherein generation parameters and heat transfer parameters are chosen from condition, that during combustion of fuel layer central rod is heated through heat-conducting shell to temperature, sufficient for evaporation of material of central rod and formation of aerosol inhaled smoker, but less than ignition temperature thereof, mouthpiece inside has cylindrical bushing, dividing internal space of mouthpiece into a central channel, adjacent to end of central rod, and an annular channel, adjacent to fuel layer and in which there is a separating partition in form of a ring, wherein separating partition is installed with possibility of movement towards open part of mouthpiece due to rarefaction, created during drawing, and reverse movement towards end of fuel layer after drawing due to an elastic element, associated with partition and storing potential energy during drawing.EFFECT: technical result is preventing penetration of combustion products of fuel layer into inhaled air stream.24 cl, 17 dwg
ethod of firefighting using a nano-powder and device for its implementation (versions) // 2607770
FIELD: nanotechnology.SUBSTANCE: invention relates to nanotechnologies in field of fire-fighting equipment. Method of firefighting with a nano-powder comprises delivering a shell with the firefighting powder to the fire seat using a thrower, destruction of said shell and supplying of firefighting substance to the fire seat in the form of nano-powder.EFFECT: proposed technical solution relates to the throwing firefighting means.3 cl, 4 dwg
Smoking article // 2607767
FIELD: tobacco industry.SUBSTANCE: invention relates to a smoking article, which consists of a smoking part and a mouthpiece connected thereto, wherein smoking part comprises central core made from material which forms when heated an aerosol which is inhaled by smoker, heat-conducting shell surrounding central core, and a fuel layer outside heat-conducting shell, wherein parameters of heat release during combustion of fuel layer and heat transfer parameters of heat-conducting shell are chosen from condition, that during combustion of fuel layer central core is heated through heat-conducting shell to temperature sufficient for evaporation of material of central core and formation of aerosol inhaled by smoker, but lower than temperature of its ignition, mouthpiece has a central channel, adjacent to end of central rod of smoking part to allow passage of aerosol inhaled by smoker, and an annular cavity with an open end, adjacent to end of fuel layer of smoking part, and closed end face on opposite side, in central channel of mouthpiece there is an air rotor with blades, enabling rotation of air rotor around longitudinal axis of article due to air stream inhaled by smoker when drawing, in annular cavity of mouthpiece there is an impeller, connected to air rotor with possibility of transferring axial rotation from air rotor to impeller, and annular cavity is connected with outer space by means of at least one hole.EFFECT: technical result is preventing penetration of combustion products of fuel layer into respiratory tracts of smoker.17 cl, 16 dwg
Shoes intended for winter sports or walking // 2607765
FIELD: personal usage items.SUBSTANCE: invention relates to shoe (1) intended for going in for winter sports or for walking, comprising outer shell (2, 2', 20, 26, 26', 34, 42) of rigid material and inner boot (20), the shell (2, 2', 20, 26, 26', 34, 42) includes the heel part (22, 28, 28', 39, 44) intended for user’s heel, and the heel part (22, 28, 28', 39, 44) is extended forward with part (6) in the form of a blade which limits bending zone, and the heel part (22, 28, 28', 39, 44) comprises a side wall (5, 31) and bottom, the bottom of the heel part and the part in the form of blade partially outline the shoe sole.EFFECT: technical result consists in providing torsional stiffness, good flexibility in bending and reduced weight.30 cl, 24 dwg
ethod of fire extinguishing with nanopowder using powder fire extinguisher and powder fire extinguisher // 2607761
FIELD: fire safety.SUBSTANCE: invention refers to extinguishing powders made in the form of a nanopowder. Core of the proposed device is that in a powder fire extinguisher comprising a housing filled with a fire-extinguishing powder, a device for its discharge and supply to the body of fire, a stop-start device and a powder sprayer in the controlled zone, the fire-extinguishing powder is made in the form of a nanopowder. Powder fire extinguisher contains a housing filled with a fire-extinguishing powder, a device for its discharge and supply to the body of fire, a stop-start device and a powder sprayer in the controlled zone, the fire-extinguishing powder is made in the form of a nanopowder.EFFECT: proposed technical solution is easy in operation and can be used in a normal powder fire extinguisher to supply the nanopowder in case of fire to the controlled zone.2 cl, 1 dwg
Calming/soothing device for babies and method of use // 2607760
FIELD: personal use and household items.SUBSTANCE: invention relates to calming/soothing device for babies and is aimed at increasing the device efficiency. Device includes the basic moving platform which performs reciprocal movement, and the drive which enables reciprocal movement of the basic moving platform. Moving headboard platform is connected with the basic moving platform, and at least one of the instruments sensitive to movement and sound activated device are located on or near the moving headboard platform, articulated with the basic moving platform. Logic circuit connects at least one of the devices sensitive to movement and sound activated devices of the calming /soothing device for babies to the basic moving platform by means of which the detected signals modulate movement of the basic moving platform.EFFECT: sound generator is connected with logic circuit.20 cl, 16 dwg
Beverage cartridge and filter element // 2607759
FIELD: food industry; production technology.SUBSTANCE: invention relates to a beverage cartridge, intended for use in beverage preparation machine, comprising a filter element, which comprises a plurality of microholes, passing through it from first surface to second surface located opposite first surface. Filter element facilitates brewing due to high permeability for fluid medium from beverage brewed from particles, suitable for brewing, wherein said fluid medium contains a liquid and gas, and prevents accumulation of gas in device for brewing by removing gases released from medium of beverage contained in beverage cartridge, during brewing. Filter element can be used in rigid, semi-rigid or soft capsule inserted into machine for brewing beverages. In particular, present invention relates to brewing coffee and coffee products in a coffee brewing machine intended for receiving capsules containing coffee particles, through which water is passed for brewing coffee therefrom.EFFECT: invention discloses a beverage cartridge and filter element.35 cl, 5 dwg
Device for automatic pucks feed for training hockey // 2607754
FIELD: sports.SUBSTANCE: invention relates to sport training equipment and can be used for players training in development of hits in ice hockey game. Impact unit also comprises replaceable lever 9, made in form of eccentric and installed on gearbox 10 shaft axis, connected with electric motor 11 with frequency converter. In order to change impact frequency to puck 15, replaceable lever 9 can be made three-pointed (versions) or with different number of tabs. Electric motor 11 is installed on helical shafts 12 by means of nut connections 13. Helical shafts 12 are rigidly connected to tabletop 2 horizontal surface. Device also includes pucks 15 feed pipe 14, located at right angle to tabletop 2 surface and connected to pucks output angle changing unit, made in form of composite bracket 16, connected to three-way magnetic valve and electric motor 17.EFFECT: technical result, consists in possibility to change pucks output speed and pucks output angle changing, is achieved due to fact, that device comprises rectangular frame 1, made of metal shape (L-bars), rectangular metal tabletop 2 with partial fluoroplastic coating, connected to rectangular frame 1 by spring dampers 3, impact unit, including striker 4 made in form of rigidly connected to each other flat rectangular plate 5 and rectangular bar 6 with impact springs 7 unit and pneumatic oscillations damper 8 attached to its end face.4 cl, 3 dwg
ethod of package production sensitive to adhesive tape pressure // 2607749
FIELD: packaging industry.SUBSTANCE: group of inventions relates to production of package sensitive to adhesive tape pressure, suitable for industrial production (versions). Method of package production sensitive to adhesive tape pressure, which represents sensitive to adhesive tape pressure package 10, in which sensitive to pressure adhesive tape 14 is arranged. Latter comprises substrate 18 and adhesive layer 12, deposited on one substrate surface 18. Sensitive to pressure adhesive tape package also comprises anti-adhesion sheet 16, on which adhesive tape adhesive layer is fixed with possibility of anti-adhesion sheet subsequent removal. In this method adhesive tape 14 is attached to anti-adhesion sheet 116 main material and folded in halves. Then plurality of adhesive tapes 14 is subjected to heat sealing and temporarily attached to one anti-adhesion sheet 116 main material and anti-adhesion sheet 116 primary material is cut.EFFECT: technical result achieved when using method according to invention consists in order to improve production efficiency.8 cl, 24 dwg
ethod of film stretching // 2607742
FIELD: manufacturing technology.SUBSTANCE: invention relates to laminated material producing method containing non-woven fabric and film. This method comprises heating initial thermoplastic polymer material film, containing at least one low-melting polymer component and at least one high-melting polymer component, until at least partially melted state. At that, at least one low-melting polymer component is in melted liquid state, and at least one high-melting polymer component is not in melted liquid state. Melting is performed by means of at least one heating cylinder. Then performing cooled by passing of partially melted film via cooled cylinders clamp. Film is stretched between at least one heating cylinder and cooled cylinders clamp. Produced films can be laminated together with nonwoven material. Laminated material is used in medicine or hygiene fields.EFFECT: technical result achieved when using method and laminated material according to inventions, consists in production of thinner films.9 cl, 1 dwg, 3 tbl, 1 ex
ethod of plough share hardening // 2607680
FIELD: agriculture.SUBSTANCE: invention can be used for agricultural machines tillage tools working surfaces strengthening, operating under abrasive wear conditions. Protective coating is applied on ploughshare surface in several continuously repeating cycles by spark alloying of ploughshare surface and subsequent protective cusps arc surfacing. In each cycle electric-spark alloying is carried out by oscillating electrode, made of abrasion-resistant material, by doping current pulses with energy of 1.5–10.0 J for 5–60 s to produce protective coating with thickness of up to 0.5 mm. Then current supply to said spark alloying electrode is disconnected and it is supplied with constant welding current of positive polarity with value of 80–450 A for 20–120 c for overlay welding by electrode material of protective cusp with height of 0.8–1.5 mm.EFFECT: method ensures production of wear-resistant coating with high strength of its adhesion with ploughshare parent metal and ploughshare ability to self-sharpening.3 cl, 2 dwg
Combined application of proteins vip3ab and cry1fa to generate insect resistance // 2607666
FIELD: biochemistry.SUBSTANCE: invention relates to biochemistry, namely to transgenic plant, which has resistance to antler moth (FAW; Spodoptera frugiperda), containing DNA, which codes Vip3Ab, DNA, which codes Cry1Fa, and DNA, which codes third protein selected from group, consisting of CrylC, CrylD and CrylE, its seed, as well as to method of preventing generation of resistance to proteins Vip3Ab and Cry1Fa in antler moth using it. Also set of plants in field, containing plurality of said transgenic plants and plants, which do not contain proteins of Bacillus thuringiensis (non-Bt plants), and mixture of seeds comprising seeds of non-Bt plants and multitude of said seeds are also disclosed. Invention also relates to composition for controlling lepidoptera pests, containing cells expressing Cry1Fa, Vip3Ab and third protein selected from group consisting of Cry1C, Cry1D and Cry1E, as well as to method of fighting antler moth using it.EFFECT: invention provides effective fighting against antler moth.34 cl, 3 dwg, 2 tbl, 8 ex
Rectal suppositories with analgesic action // 2607661
FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to drugs, and can be used for production of rectal suppositories for relieving of pain of various origin: postoperative pain, vertebrogenic radicular pain, arthritis, cancer pain, cardialgia, headache, dysmenorrhea, kidney and liver colics. Rectal suppositories proposed by authors have analgesic action and contain preparation of non-steroidal row and base, differing by fact, that preparation of non-steroidal row contains ketorolac and additionally contains amitriptyline, while base contains silicon glicerolates in 3-molar excess of glycerine composition Si(C3H7O3)4⋅3C3H8O3 and polyethylene glycol PEG-4000 with following ratio of components, calculated in g per one suppository: ketorolac 0.021÷0.031, amitriptyline 0.003÷0.008, PEG-4000 1.793÷1.804, silicon glicerolates 0.768÷0.773.EFFECT: production of rectal suppositories.1 cl, 2 tbl, 2 ex
Composition comprising an antibiotic and a dispersant or an anti-adhesive agent // 2607660
FIELD: medicine.SUBSTANCE: invention relates to products for treating or preventing of bacterial infection, comprising an antibiotic agent and a second agent representing a dispersant or an anti-adhesive agent, where antibiotic is a tobramycin, colistin, gentamycin or ciprofloxacin, and a dispersant or an anti-adhesive agent is a cysteamine.EFFECT: treatment or prevention of bacterial infection.1 cl, 10 dwg, 2 tbl, 2 ex
Transdermal therapeutic system for 5-aminolevulinic acid hydrochloride // 2607657
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine. Disclosed is transdermal therapeutic system, which includes active substance impermeable back layer, containing active substance, polymer matrix and separable protective layer, wherein active substance is represented by 5-aminolevulinic acid hydrochloride and polymer matrix basic polymer is adhesive polyacrylate. Transdermal therapeutic system is applicable for diagnosing and treating of skin cancer pre-stages, such as actinic keratosis, as well as skin oncological diseases.EFFECT: transdermal therapeutic system is fairly well sticks to skin and does not cause irritation thereof.15 cl, 1 dwg, 4 ex
ethod of producing dalfampridin tablets with prolonged action // 2607655
FIELD: pharmaceutics.SUBSTANCE: invention relates to chemical-pharmaceutical industry and medicine. Method of producing dalfampridin pellets is disclosed, characterized by preparing intra-granulated mixture by screening dalfampridin together with hydroxypropyl methyl cellulose with viscosity of 80–120 MPA˙s, mixing with microcrystalline cellulose with particle size of 50–90 mcm and aerosil, compaction, mixing with magnesium stearate, it is followed by granulation of mixture by rolling, extra-granulated mixture is added to obtained granules consisting of microcrystalline cellulose with particle size of 50–90 mcm and aerosil, mixed to homogeneous state, magnesium stearate is added, tablets are pressed and coated with their shell by spraying water solution of white Opadraja till tablet weight increases by 1.0–3.0 %.EFFECT: obtained solid shape has improved pharmacological and process characteristics.6 cl, 1 dwg, 3 tbl, 3 ex
ethod of producing nanocapsules of adenine in carrageenan // 2607654
FIELD: nanotechnology.SUBSTANCE: invention relates to a method of producing nanocapsules of adenine. Specified method is characterized by that carrageenan in benzene is added with glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as a surfactant, the produced mixture is stirred, added with adenine powder, after formation of an independent solid phase is slowly added with petroleum ether, the produced suspension of nanocapsules is filtered, washed with petroleum ether and dried, herewith the ratio of nucleus/shell in the nanocapsules makes 1:3, 1:1 or 5:1.EFFECT: invention provides faster and easier process of nanoencapsulation of adenine, as well as higher mass output.1 cl, 1 dwg, 4 ex
ethod for simulating bone-reconstructive surgeries in treating new growths of jaw bone in childhood // 2607651
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely, to maxillofacial surgery and orthodontics. For simulating bone-reconstructive surgeries in treating new growths of jaw bone in childhood is carried out KT examination of skull with subsequent reconstruction in 3D programs and create a three-dimensional model of skull, identify new growth, calculate basic parametric data of neoplasms and virtually it is removed in the resulting model, then virtually fill a defect or flaw, then prototyping reconstructive models of jaws or endoprosthesis using a 3D printer. For virtual removal of neoplasm is performed a 3D cephalometry, on the received 3D model of skull manually placed cephalometric marks at maximum increase of screen resolution, using simultaneously different projections, perspective, right, left, top, front and by varying the transparency of the image from 0 to 100 %, determined 48 cephalometric parameters against which is carried out a virtual replacement of defect or flaw zone with subsequent virtual correction of jaw bones during the staged orthodontic-surgical treatment.EFFECT: method allows to simulate and predict the staged surgical-orthodontic and orthopaedic treatment in a child until its growth, as well as reduce a probability of unplanned step operations.1 cl, 21 dwg, 4 tbl, 1 ex
Full spectrum led illuminator // 2607645
FIELD: lighting.SUBSTANCE: invention relates to lighting engineering. Device for outputting light to a light guide to illuminate an imaged object comprises a plurality of solid-state light-emitting sources, each independently supplied with energy, independently controlled and emits light at wavelength, different from wavelengths emitted by other light-emitting sources. Device also includes a heat sink configured for thermal coupling of plurality of solid-state light-emitting sources and conduction of heat formed by plurality of solid-state light-emitting sources, optical elements intended for collection, collimation and combination of radiation from plurality of solid-state light-emitting sources into a combined light beam, intended for optical coupling with light guide.EFFECT: higher illumination brightness with full spectrum of visible radiation.4 cl, 4 dwg
N-9-substituted purine compounds, compositions and methods of use // 2607635
FIELD: chemistry.SUBSTANCE: present invention relates to novel compounds of formula I-A, having properties of inhibitors of kinase of phosphoinositide-3-kinase family mTOR and PI3K, for use in treating cancer, as well as for preparing drugs for treating cancer. In compounds of formula I-A R1 is selected from a group comprising cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidin-1-yl, azetidin-2-yl, azetidin-3-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, oxetan-2-yl, oxetan-3-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydropyran-2-yl, tetrahydropyran-3-yl and tetrahydropyran-4-yl, oxepan-2-yl, oxepan-3-yl, oxepan-4-yl, phenyl pyrrol-2-yl, pyrrol-3-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, furan-2-yl, furan-3-yl, thien-2-yl, thien-3-yl, thiazol-2-yl, thiazol-3-yl, thiazol-4-yl, imidazol-1-yl, imidazol-4-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, pyrimidin-1-yl, pyrimidin-2-yl, pyrimidin-3-yl, pyrazin-2-yl, pyridazin-2-yl, pyridazin-3-yl and triazin-2-yl, where R1 substituted by 0-3 substitutes RR1, selected from a group consisting of halogen, F, Cl, Br, I, -ORa, -C(O)Ra, -Rc; where Ra is selected from hydrogen or C1-6alkyl, Rc is C1-6alkyl; R2 is selected from a group comprising hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl; R3 is a morpholine-4-yl, where group R3 is substituted with 0–3 substitutes RR3, selected from a group consisting of -Ri, halogen, where Ri is selected from C1-6alkyl, C1-6haloalkyl; D is -NR4C(O)NR5R6 or -NR5R6, where R4 and R5 each denotes hydrogen and R6 is C1-6alkyl, C1-6haloalkyl oxetan-3-yl and pyridyl-on.EFFECT: treatment of cancer.11 cl, 1 tbl, 26 ex
Romidepsin solid forms and use thereof // 2607634
FIELD: chemistry.SUBSTANCE: invention relates to novel crystalline form C of romidepsin, a pharmaceutical composition containing form C of romidepsin.EFFECT: treatment of skin T-cell lymphoma.3 cl, 12 dwg, 19 tbl, 16 ex
Aromatic derivatives of sulfanilamides carbonic anhydrase ii (ca ii) inhibitors, methods for production and use thereof // 2607630
FIELD: chemistry.SUBSTANCE: present invention relates to novel aromatic sulphonamide derivatives, general formula 1 and pharmaceutically acceptable salts thereof, which are selective inhibitors of carbonic anhydrase II (CA II). Substituted sulphonamides correspond to general formula 1 ,where A is phenyl or thiophene; R1 is C1-C5alkyl, C-3C6cycloalkyl, -C(O)R3; provided that R1 is not methyl, when A is phenyl, R2 represents hydrogen; R3 is a 5-6 member heterocyclyl with one or two heteroatoms, selected from nitrogen or oxygen atoms; R2 is C1-C3alkyl, C1-C3alkoxy. Invention also relates to a method of producing compounds of general formula 1. Method involves two stages: a) sulphochlorination of corresponding oxazole derivative of general formula 5 (a-o) or 6 (a-j) with a mixture chlorosulphonic acid and thionyl chloride to produce intermediate sulphochlorides of formula 7 (a-o) or 8 (a-j), respectively, and b) with subsequent conversion of obtained sulphochlorides into primary sulphamides of formula 9 (b-o) or 10 (a-j) by reacting with ammonia according to following scheme ,where ,where R1 is C1-C5alkyl, C3-C6cycloalkyl; NR'Rʺ is a morpholine or pyrrolidine.EFFECT: compounds can be used for treating glaucoma, in particular, open-angle glaucoma, and other diseases caused by high intraocular pressure, age-related macular degeneration, diabetic macular edema, diabetic retinopathy, hypertensive retinopathy and retinal vasculopathy mediated by activity of carbonic anhydrase II.11 cl, 2 dwg, 2 tbl, 57 ex
N-alkylsubstituted benzo- and (pyrido[2,3-b]thieno)pyrrolo[1,2-a][1,4]diazepin-6-ones - antidotes of herbicide of hormonal action 2,4-dichlorophenoxyacetic acid on sunflower // 2607629
FIELD: chemistry.SUBSTANCE: invention relates to novel synthetic, biologically active chemical substances from series of heterocyclic compounds of formula 1 EFFECT: technical result is synthesis of novel compounds in a series of condensed pyrrolo[1,2-a][1,4]benzodiazepines of formula 1a-d in order to expand range of biologically active substances, obtained synthetically, for use in agriculture as antidotes of herbicide of hormonal action 2,4-D.1 cl, 3 tbl, 6 ex
Sodium salt of 2-methylthio-6-cyano-1,2,4-triazolo[5,1-c]-1,2,4-triazin-7(4h)-one, trihydrate // 2607628
FIELD: chemistry.SUBSTANCE: invention relates to a sodium salt of 2-methylthio-6-cyano-1,2,4-triazolo[5,1-c]-1,2,4-triazin-7(4H)-one, trihydrate, which exhibits antiviral action on influenza .EFFECT: obtaining a novel compound having antiviral activity.1 cl, 1 dwg, 2 tbl, 4 ex
Smoking article including dual heat-conducting elements // 2607608
FIELD: tobacco industry.SUBSTANCE: invention relates to a smoking article comprises a heat source, an aerosol-forming substrate downstream of heat source and dual heat-conducting elements around smoking article. Smoking article comprises a heat source; an aerosol-forming substrate located downstream of heat source; a first heat-conducting element around and in contact with a rear portion of heat source and an adjacent front portion of aerosol-forming substrate and a second heat-conducting element around at least a portion of first heat-conducting element, wherein least part of second heat-conducting element is radially separated from first heat-conducting element.EFFECT: technical result of invention is improved characteristics of smoking and improved control of conductive heating of aerosol-forming substrate to facilitate maintenance of substrate temperature during smoking.17 cl, 3 dwg
Leg for surgical table // 2607607
FIELD: medicine.SUBSTANCE: invention relates to surgical table leg. Leg of surgical table comprises at least two sliding transport rollers. Surgical table in retracted position of transport rollers stands on support element of surgical table. Surgical table in extended position of transport rollers can move on rollers. There is first mechanical setting unit, by means of which position of first transport roller can vary, at least, from retracted position to extended position. There is second mechanical setting unit, by means of which position of second transport roller can vary, at least, from retracted position to extended position. First mounting unit and second mounting unit can be driven by first drive unit, which is connected by mechanically coupled mean to first and second mounting units. Mechanical coupler is chain or belt, wherein first and second mounting units are connected to first drive unit by means of chain or belt.EFFECT: invention aims at simplified use of legs surgical table.16 cl, 11 dwg
Pneumatic seeds dispenser housing with protection of seeds passage // 2607605
FIELD: agriculture.SUBSTANCE: pneumatic seed dispenser has housing having dosing seeds side and evacuation side, wherein said seeds dosing side includes seed stock, in which seeds are located in housing. In housing disc is installed with possibility of rotation around axis and having plurality of seed cells, spaced radially around axis for placement and retention of seeds. At that, housing seeds dosing side has outer lateral wall arranged radially from housing axis and extending in axial direction at least with part of side wall adjacent to seeds stock, shifted radially outward from rest part of external side wall to provide seeds with additional space to move around and retraction onto disc seed cell or into it. Housing shifted part is at least partially closed with safety element.EFFECT: invention allows to improve seeds falling into disc cells and increase accuracy of sowing.20 cl, 23 dwg
Prevention of formation of bezoar by limitation of content of mineral substances in ration // 2607604
FIELD: domestic animals.SUBSTANCE: group of inventions relates to fodder production. Method for preventing and/or prophylaxis of hair balls formation in animals involves feeding animals with composition, containing certain amount of calcium, phosphorus and sodium. Wherein composition is added in amount and during time sufficient for preventing and/or prophylaxis of hair balls formation in animals. Fodder composition for preventing and/or prophylaxis of hair balls formation in animals contains in % of dry weight of composition: from 5 % to 75 % of proteins; from 5 % to 50 % of fats; from 5 % to 75 % of carbohydrates; 0.74 % or less of calcium; from 0.50 % to 0.69 % of phosphorus; 0.28 % or less of sodium. Animal can be companion animal. Method for production of fodder product, intended for consumption by companion-animals, involves mixing suitable sources of proteins, fats, carbohydrates, mineral substances and vitamins to produce fodder composition, mentioned above.EFFECT: implementation of group of inventions provides prevention of and/or prophylaxis of hair balls formation in companion-animals and helps removal and/or release of hair balls in companion-animals due to limitation of content of mineral substances in ration.19 cl, 2 tbl, 1 ex
ethod of processing sugar beet prior to laying for storage // 2607603
FIELD: agriculture.SUBSTANCE: invention relates to agriculture, namely to methods of processing plant cultivation products while storage. Method of processing sugar beet prior to laying for storage includes treatment of beet root crops at moment of their laying into piles with liquid antiseptic. As liquid antiseptic solution of sodium salt of dichloroisocyanuric acid is used with weight ratio of 0.075 %, taken in amount of 2 % to beet-root weight.EFFECT: invention provides reduced losses of saccharose, reduced accumulation of soluble nonsugars, high efficiency of processing of sugar beet and preservation of quality of root crops during storage.1 cl, 1 tbl, 1 ex
ethod for production of protein-vitamin-mineral functional product // 2607602
FIELD: food industry.SUBSTANCE: invention relates to food industry and can be used during preparation of functional purpose protein-vitamin or protein and mineral products using soya. Method envisages combined disintegration of soya seeds with Laminaria and water in ratio of soya seeds:Laminaria:water of 1:1:7. Then performing separation of liquid soya-Laminaria fraction from mixture and protein coagulation at temperature of 70–75 °C by adding of ascorbic acid 5 % aqueous solution at ratio of soya-Laminaria fraction:ascorbic acid of 1:0.15. Then obtained coagulate and remaining insoluble soya-and-Laminaria residue is molded and conditioned till moisture content of 9–50 %.EFFECT: invention allows to produce functional food products with high organoleptic indices, as well as nutritional and biological value.1 cl, 1 dwg, 1 tbl, 1 ex
ethod for preparation of fish culinary products // 2607601
FIELD: food industry.SUBSTANCE: method comprises preparation of fish cutlet mass from fish fillet by milling with addition of salt. Method also uses flax meal, boiled cauliflower, cabbage broth and iodized salt. All components are used at specified weight ratio. Products are subjected to gentle thermal treatment in a medium of wet saturated steam.EFFECT: invention provides preparation of fish culinary products with high nutritive value and reduced caloric content.1 cl, 3 tbl, 1 ex
ethod of producing hybrid two-phase system of delivery of poorly soluble and insoluble in water biologically active substances with controlled release kinetic // 2607598
FIELD: pharmaceutics.SUBSTANCE: group of inventions relates to pharmaceutical industry, namely, to system of delivery of poorly soluble and insoluble biologically active substances (BAS) with controlled release kinetics, which is spherical nanoparticles containing hydrophobic core formed of biocompatible and biodegradable hydrophobic polymers, such as polyhydroxybutyrate, polylactide, polyglycolide, polydioxanone, poly-ε-caprolactone, polyhydroxyvalerate, copolymer of lactic and glycolic acids, in which there is a partially soluble or insoluble in water BAS; wherein hydrophobic core is surrounded with hydrophilic fragments of amphiphilic polymers consisting of one fragment of water-soluble carbon chain polymer with molecular weight Mn=1,000-30,000 Da and one end hydrophobic group, including one aliphatic radical with carbon atoms number in carbon chain 9÷20, as well as to method of producing such system of delivery.EFFECT: group of inventions provides higher water compatibility of poorly soluble and insoluble BAS, increased stability of medicinal substances and possibility of controlling release rate of BAS.6 cl, 7 ex, 6 tbl, 15 dwg
ultiple emulsion // 2607597
FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical and cosmetic industry and represents multiple emulsion for application of at least one pharmaceutical or cosmetic active substance, which includes external aqueous phase W1, oil phase O, dispersed in external aqueous phase, and inner aqueous phase W2 dispersed in oil phase O, where in inner aqueous phase W2 there is at least one electrolyte, selected from group of alkali and alkali-earth metals halides and sulphates, and at least one hydrophilic active substance, where multiple emulsion is characterized by, that external aqueous phase W1 contains hydrophilic emulsifier, which is ethylene oxide and propylene oxide polymer, oil phase O is formed by triacylglycerols and contains lipophilic emulsifier from dimeticones group, and hydrophilic active substance, which is oligonucleotide having sequence according to SEQ ID No: 1 – SEQ ID No: 148 or SEQ ID No: 150.EFFECT: invention provides high stability, efficient protection of active substances against external effects and protection against microorganisms damages.20 cl, 1 tbl, 3 dwg
Combined anticancer therapy // 2607596
FIELD: medicine.SUBSTANCE: present invention relates to combined therapy with {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4difluorophenyl} amide of propane-1-sulphonic acid (compound 1) or its pharmaceutically acceptable salt and EGFR inhibitor, selected from erlotinib and cetuximab, for treating cancer, containing b-Raf with V600 mutation, namely colorectal cancer, melanoma and thyroid cancer.EFFECT: combination of compound 1 with EGFR inhibitor leads to improved anti-tumor effects, which considerably exceed the results, obtained for each compound separately, without increasing the toxicity.20 cl, 6 ex, 15 tbl, 9 dwg
Rasagiline compositions of prolonged release and use thereof // 2607595
FIELD: pharmaceutics.SUBSTANCE: group of inventions refers to pharmaceutics. Oral pharmaceutical composition is described in form of prolonged release for treating neurodegenerative disease or damage of nervous system. Above composition contains R(+)-N-propargyl-1-aminoindan (rasagiline) as active substance. Composition contains pellets with prolonged release and pharmaceutically acceptable carrier. Said pellet includes: I) inert core of pellet; II) layer with active substance, polyvinyl pyrrolidone and talc; III) optionally insulating layer with polyvinyl pyrrolidone; IV) prolonged release coating layer with ethylcellulose and polyethylene glycol. Use of said composition and method of treating neurodegenerative disease or damage of nervous system are also described.EFFECT: invention provides intensified effect on above diseases.16 cl, 9 dwg, 17 tbl, 11 ex
Combination of ozogamicin inotuzumab and torizel for treating cancer // 2607594
FIELD: medicine.SUBSTANCE: invention relates to therapeutic method of treating cancer, which is non-Hodgkin’s lymphoma; method involves stage of introducing simultaneously or successively effective number of ozogamicin inotuzumab (SMS-544) in dose of 0.4 mg/m2 up to 1.8 mg/m2 every 4 weeks throughout 6 cycles and temsirolimus in dose of 5 to 175 mg/week during disease progression.EFFECT: invention provides low toxicity, associated with treatment using ozogamicin inotuzumab or temsirolimus.7 cl, 8 ex, 11 tbl
ethod for prevention of postoperative complications accompanying surgical management of patients with congenital malformations of external and middle ear // 2607593
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to otorhinolaryngology, and can be used for prevention of postoperative complications accompanying surgical management of patients with congenital malformations of external and middle ear. For this purpose, during the early postoperative period the ear is being cleaned, and the external acoustic meatus is being washed with an octenisept solution diluted in distilled water 1:5. Then, a session of endaural electrophoresis is performed with the Longidaza solution for 10–30 minutes. After the session of electrophoresis, a turunda impregnated with a mixture of preparations "Longidaza" and "Fermenkol" gel, 0.5 ml of each is being introduced into the external acoustic meatus. Turunda is being introduced 3 times a day for 10–15 days.EFFECT: invention enables reducing the treating period and preventing commissure formation in the external acoustic meatus.1 cl, 2 ex
New pharmaceutical composition containing nsaid and cyclodextrin // 2607592
FIELD: medicine.SUBSTANCE: invention refers to medicine and consists in liquid composition for treating sore throat, containing 1–5 % wt/vol. of flurbiprofen; 5–10 % wt/vol. of cyclodextrin; up to 5 % wt/vol. of buffer agents and 80–90 % wt/vol. of water.EFFECT: technical result consists in physically and chemically pure stable solution of flurbiprofen of sufficient concentration, solution has no undesirable taste and does not contain alcohol as auxiliary solvent.21 cl, 5 ex, 2 tbl, 5 dwg
Biologically active additive for making cosmetics // 2607591
FIELD: cosmetology.SUBSTANCE: invention refers to cosmetic industry and represents a biologically active additive for making cosmetic compositions, containing modified dextrane and cosmetically acceptable carrier, differing by the fact, that dekstranal with molecular weight 20–75 kDa is used as modified dextran, wherein ingredients of additive are taken in certain proportions, wt%.EFFECT: invention provides anti-inflammatory and moisturizing effect with simultaneous improvement of elastometry and profilometry of skin.3 cl, 4 ex, 4 tbl
 
2550913.
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